FLY_GENE SYMBOL FULL_NAME URL SECONDARY_FBGNS GENE_CLASS GO_MOLECULAR_FUNCTION GO_BIOLOGICAL_PROCESS GO_CELLULAR_COMPONENT SYNONYMS PROTEIN_DOMAINS CG_SYMBOL DATE_LAST_UPDATED DATA_VERSION ZEBRAFISH_ORTHOLOGS YEAST_ORTHOLOGS WORM_ORTHOLOGS XENOPUS_ORTHOLOGS MOUSE_ORTHOLOGS HUMAN_ORTHOLOGS RNA_EXPRESSION_STAGE RNA_EXPRESSION_TISSUE PROTEIN_EXPRESSION_STAGE PROTEIN_EXPRESSION_TISSUE FLYBASE_EXP_LINK PHENO_CLASS PHENO_MANIFEST DRSC SCREEN AVG_Z_SCORE_BASELINE_S2R AVG_Z_SCORE_10_INSULIN_S2R AVG_Z_SCORE_BASELINE_S2R_MTDER AVG_Z_SCORE_10_EGF_S2R_MTDER AVG_Z_SCORE_10_EGF_KC AVG_Z_SCORE_30_EGF_KC HUMAN_DISEASE HUMAN_ORTHOLOG_DESCRIPTION FBgn0002413 dco discs overgrown http://flybase.org/reports/FBgn0002413 "FBgn0011349, FBgn0011508, FBgn0024895, FBgn0027967, FBgn0028129" protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 protein binding ; GO:0005515 | inferred from physical interaction with Bdbt kinase activity ; GO:0016301 | inferred from mutant phenotype protein binding ; GO:0005515 | inferred from physical interaction with per protein serine/threonine kinase activity ; GO:0004674 | inferred from sequence or structural similarity protein kinase activity ; GO:0004672 | inferred from direct assay protein serine/threonine kinase activity ; GO:0004674 | inferred from biological aspect of ancestor with PANTHER:PTN000225966 protein serine/threonine kinase activity ; GO:0004674 | non-traceable author statement" negative regulation of apoptotic process ; GO:0043066 | inferred from mutant phenotype regulation of ecdysteroid secretion ; GO:0007555 | inferred from mutant phenotype cellular response to light stimulus ; GO:0071482 | inferred from direct assay protein phosphorylation ; GO:0006468 | traceable author statement positive regulation of cell division ; GO:0051781 | inferred from mutant phenotype locomotor rhythm ; GO:0045475 | inferred from mutant phenotype protein phosphorylation ; GO:0006468 | non-traceable author statement peptidyl-serine phosphorylation ; GO:0018105 | inferred from biological aspect of ancestor with PANTHER:PTN000225966 protein phosphorylation ; GO:0006468 | inferred from direct assay positive regulation of proteasomal ubiquitin-dependent protein catabolic process ; GO:0032436 | inferred from direct assay regulation of cell shape ; GO:0008360 | inferred from biological aspect of ancestor with PANTHER:PTN000225966 regulation of protein import into nucleus ; GO:0042306 | traceable author statement circadian rhythm ; GO:0007623 | traceable author statement regulation of circadian rhythm ; GO:0042752 | inferred from mutant phenotype establishment of imaginal disc-derived wing hair orientation ; GO:0001737 | inferred from mutant phenotype circadian rhythm ; GO:0007623 | inferred from mutant phenotype positive regulation of cell growth ; GO:0030307 | inferred from mutant phenotype cell communication ; GO:0007154 | inferred from mutant phenotype circadian rhythm ; GO:0007623 | inferred from mutant phenotype inferred from physical interaction with per endocytosis ; GO:0006897 | inferred from biological aspect of ancestor with PANTHER:PTN000226268 rhythmic behavior ; GO:0007622 | traceable author statement circadian rhythm ; GO:0007623 | inferred from direct assay locomotor rhythm ; GO:0045475 | non-traceable author statement behavioral response to cocaine ; GO:0048148 | non-traceable author statement phosphorylation ; GO:0016310 | inferred from direct assay eclosion rhythm ; GO:0008062 | traceable author statement behavioral response to cocaine ; GO:0048148 | inferred from mutant phenotype establishment of ommatidial planar polarity ; GO:0042067 | inferred from mutant phenotype sleep ; GO:0030431 | non-traceable author statement protein autophosphorylation ; GO:0046777 | inferred from direct assay positive regulation of actin filament polymerization ; GO:0030838 | inferred from mutant phenotype positive regulation of protein catabolic process ; GO:0045732 | inferred from direct assay negative regulation of protein phosphorylation ; GO:0001933 | inferred from mutant phenotype imaginal disc growth ; GO:0007446 | inferred from mutant phenotype Wnt signaling pathway ; GO:0016055 | inferred from mutant phenotype positive regulation of protein catabolic process ; GO:0045732 | inferred from mutant phenotype cytoplasm ; GO:0005737 | traceable author statement cytoplasm ; GO:0005737 | inferred from direct assay nucleus ; GO:0005634 | traceable author statement nucleus ; GO:0005634 | inferred from direct assay plasma membrane ; GO:0005886 | inferred from direct assay "dco, CK1epsilon, DBT, dbt, Dbt, CKIepsilon, DBT/CK1epsilon, ddbt, ck1epsilon, DCO/CKIe, CG2048, l(3)j3B9, l(3)discs overgrown, l(3)S144701, l(3)S053813, 1460/09, 1447/01, 1396/02, 0915/10, 0538/13, l(3)dco, dco-1, l(3)discs overgrown-1, l(3)dco-1, l(3)rK215, dCKIepsilon, Dco/CK1, DCO, Dco, CK1delta/epsilon" "IPR000719:Protein kinase domain, IPR008271:Serine/threonine-protein kinase, active site, IPR011009:Protein kinase-like domain, IPR017441:Protein kinase, ATP binding site" CG2048 27-Aug-18 DroID_v2018_08 "Drer\ttbk1a, Drer\csnk1da, Drer\csnk1e, Drer\vrk3, Drer\csnk1db, Drer\ttbk2b, Drer\vrk2, Drer\csnk1a1, Drer\ttbk1b, Drer\vrk1" Scer\HRR25 "Cele\F22H10.1, Cele\kin-19, Cele\kin-20, Cele\T05C12.1, Cele\ZC373.3, Cele\F53C3.1, Cele\spe-6" "Xtro\vrk1, Xtro\csnk1e, Xtro\vrk2, Xtro\ttbk2, Xtro\csnk1d, Xtro\vrk3, Xtro\csnk1a1" "Mmus\Vrk3, Mmus\Vrk1, Mmus\Csnk1d, Mmus\Vrk2, Mmus\Csnk1e, Mmus\Ttbk2, Mmus\Csnk1a1, Mmus\Ttbk1" "Hsap\VRK1, Hsap\TTBK1, Hsap\CSNK1E, Hsap\VRK2, Hsap\CSNK1D, Hsap\TTBK2, Hsap\CSNK1A1, Hsap\LOC400927-CSNK1E, Hsap\VRK3, Hsap\CSNK1A1L" adult stage " adult lateral neuron

, photoreceptor cell

, adult brain | restricted

" "viable,size defective,fertile,circadian rhythm defective,cell polarity defective,lethal,recessive,locomotor rhythm defective,eclosion rhythm defective,cell size defective,somatic clone,cell autonomous,lethal - all die before end of pupal stage,some die during pupal stage,developmental rate defective,lethal - all die before end of larval stage,some die during larval stage,temperature conditional,partially lethal - majority die,visible,hyperplasia,wild-type,polyphasic,increased cell number,semidominant,partially lethal - majority live,behavior defective,cell death defective,flight defective,dominant,partially lethal" "wing,class IV dendritic arborizing neuron,somatic clone,ommatidium,neuron,lateral,wing disc,wing hair,cell non-autonomous,cell autonomous,crossvein,larva,imaginal disc,wing pouch,eye,vibrissae,wing vein,tarsal segment,adult external head,leg,unguis,supernumerary,larval head,dorsal organ,terminal organ,labral segment,embryonic/larval cuticle,dorsal,dorsal bridge,egg,germline clone,eye photoreceptor cell,wing margin bristle,trichogen cell,mesothoracic tergum" DRSC16929 I 1.989390382 1.027456985 0.858794289 0.581831233 -0.192138506 0.221942657 FBgn0001308 Khc Kinesin heavy chain http://flybase.org/reports/FBgn0001308 "FBgn0021886, FBgn0021889, FBgn0028613" protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR001752, InterPro:IPR019821 ATP-dependent microtubule motor activity, plus-end-directed ; GO:0008574 | traceable author statement tropomyosin binding ; GO:0005523 | inferred from physical interaction with Tm1 microtubule motor activity ; GO:0003777 | inferred from direct assay motor activity ; GO:0003774 | non-traceable author statement microtubule binding ; GO:0008017 | inferred from direct assay microtubule motor activity ; GO:0003777 | inferred from sequence or structural similarity" "axo-dendritic transport ; GO:0008088 | inferred from mutant phenotype stress granule disassembly ; GO:0035617 | inferred from mutant phenotype mitochondrion distribution ; GO:0048311 | inferred from mutant phenotype maintenance of cell polarity ; GO:0030011 | inferred from mutant phenotype pole plasm oskar mRNA localization ; GO:0045451 | inferred from mutant phenotype microtubule sliding ; GO:0051012 | inferred from mutant phenotype oocyte dorsal/ventral axis specification ; GO:0007310 | inferred from mutant phenotype centrosome separation ; GO:0051299 | inferred from mutant phenotype regulation of pole plasm oskar mRNA localization ; GO:0007317 | inferred from mutant phenotype microtubule polymerization ; GO:0046785 | inferred from mutant phenotype larval locomotory behavior ; GO:0008345 | inferred from mutant phenotype dendrite morphogenesis ; GO:0048813 | inferred from mutant phenotype heterochromatin organization involved in chromatin silencing ; GO:0070868 | inferred from mutant phenotype microtubule-based movement ; GO:0007018 | inferred from sequence or structural similarity neuron projection morphogenesis ; GO:0048812 | inferred from mutant phenotype microtubule-based movement ; GO:0007018 | inferred from direct assay transport along microtubule ; GO:0010970 | inferred from direct assay dorsal appendage formation ; GO:0046843 | inferred from mutant phenotype pole plasm assembly ; GO:0007315 | inferred from mutant phenotype skeletal muscle fiber development ; GO:0048741 | inferred from mutant phenotype axonogenesis ; GO:0007409 | inferred from mutant phenotype intracellular distribution of mitochondria ; GO:0048312 | inferred from mutant phenotype pole plasm oskar mRNA localization ; GO:0045451 | non-traceable author statement intracellular protein transport ; GO:0006886 | inferred from mutant phenotype oocyte microtubule cytoskeleton polarization ; GO:0008103 | inferred from mutant phenotype eye photoreceptor cell differentiation ; GO:0001754 | inferred from genetic interaction with DCTN1-p150 mitochondrion transport along microtubule ; GO:0047497 | inferred from mutant phenotype actin filament bundle organization ; GO:0061572 | inferred from mutant phenotype axon guidance ; GO:0007411 | inferred from mutant phenotype establishment of nucleus localization ; GO:0040023 | inferred from mutant phenotype regulation of pole plasm oskar mRNA localization ; GO:0007317 | traceable author statement cytoplasmic transport, nurse cell to oocyte ; GO:0007303 | traceable author statement" actin cap ; GO:0030478 | inferred from direct assay mitochondrion ; GO:0005739 | colocalizes_with inferred from direct assay microtubule associated complex ; GO:0005875 | inferred from direct assay kinesin complex ; GO:0005871 | inferred from sequence or structural similarity kinesin complex ; GO:0005871 | inferred from direct assay microtubule plus-end ; GO:0035371 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay microtubule ; GO:0005874 | "Khc, KHC, kinesin, khc, KIN, DK, DKH, CG7765, l(2)W12, DmKHC, l(2R)W12, Kin, l(2)k13314, Dmkin, kin, l(2)k13219, pgs, kinesin-1, Kinesin-1, DmK, KIF 5A, Kin-1, KIF5B, KIF5" "IPR001752:Kinesin motor domain, IPR019821:Kinesin motor domain, conserved site, IPR027417:P-loop containing nucleoside triphosphate hydrolase" CG7765 27-Aug-18 DroID_v2018_08 "Drer\kif3b, Drer\kif5c, Drer\kif5aa, Drer\kif3a, Drer\kif5ba, Drer\LOC100333558, Drer\kif5bb, Drer\kif3cb, Drer\kif5ab" "Scer\KIP2, Scer\SMY1" "Cele\unc-116, Cele\ZC262.7" "Xtro\kif5a, Xtro\kif5b, Xtro\kif5c, Xtro\kif3c, Xtro\kif3b" "Mmus\Kif5a, Mmus\Kif3b, Mmus\Kif3c, Mmus\Kif5b, Mmus\Kif3a, Mmus\Kif5c" "Hsap\KIF5B, Hsap\KIF5A, Hsap\KIF3B, Hsap\KIF5C, Hsap\KIF3C" adult stage head

", oogenesis stage && adult stage | female , larval stage | third instar , oogenesis stage | stage S8-10A , adult stage && oogenesis stage , embryonic stage " " germarium && oogonial cell

, female germline stem cell

, egg chamber | early & oogonial cell

ubiquitous , photoreceptor cell | apical

, oocyte | posterior

, stage S8 oocyte | anterior & dorsal && stage S9 oocyte | anterior & dorsal && stage S10A oocyte | anterior & dorsal , nurse cell

, oocyte

,

ubiquitous , follicle cell

" "paralytic,short lived,flightless,developmental rate defective,locomotor behavior defective,neurophysiology defective,lethal - all die before end of larval stage,heat sensitive,some die during larval stage,lethal,recessive,neuroanatomy defective,some die during third instar larval stage,lethal - all die before end of pupal stage,some die during pupal stage,lethal - all die before end of second instar larval stage,some die during second instar larval stage,mitotic cell cycle defective,cytokinesis defective,wild-type,partially lethal - majority die,behavior defective,visible,somatic clone,lethal - all die before end of embryonic stage,some die during embryonic stage,germline clone,body color defective,majority die during third instar larval stage,majority die during pupal stage" "eye,somatic clone,ommatidium,embryonic/larval neuromuscular junction | larval stage,dendrite,dorsal appendage,germline clone,maternal effect,embryonic/larval brain,microtubule,oocyte,microtubule | germline clone,mitochondrion,oocyte & nucleus | germ-line clone,lateral transverse muscle,eye photoreceptor cell,rhabdomere,eye photoreceptor cell & endoplasmic reticulum | somatic clone,eye photoreceptor cell & multivesicular body | somatic clone,macrochaeta,microchaeta,scutellar bristle,adult cuticle & scutellar bristle | somatic clone,embryo,stage S9 oocyte & nucleus | germ-line clone,pole plasm,pole plasm | germline clone,nurse cell fusome,mitochondrial cloud | germline clone,follicle cell & mitochondrion | germ-line clone,germline cyst & mitochondrion | germ-line clone,microtubule & oocyte | oogenesis stage S9 | germ-line clone,class IV dendritic arborizing neuron,axon,neuromuscular junction,embryonic/larval nervous system,posterior fascicle & axon,axonw+),axonwvco),oocyte nucleus,chorion | germline clone,trichogen cell,mesothoracic tergum,peripheral nervous system,mitochondrionrepo.PL, repo,embryonic/larval glial cell,embryonic/larval wrapping glial cell of the eye disc | third instar larval stage,embryonic/larval peripheral nervous system | third instar larval stage" FBgn0011760 ctp cut up http://flybase.org/reports/FBgn0011760 "FBgn0015619, FBgn0015650, FBgn0027256, FBgn0027271, FBgn0027293, FBgn0028265, FBgn0028273, FBgn0028298, FBgn0028309, FBgn0028322, FBgn0028337, FBgn0040189, FBgn0066852" protein_coding_gene "dynein light intermediate chain binding ; GO:0051959 | inferred from direct assay protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q9V9Y9 protein homodimerization activity ; GO:0042803 | inferred from direct assay dynein intermediate chain binding ; GO:0045505 | inferred from physical interaction with sw ATPase activity, coupled ; GO:0042623 | inferred from sequence or structural similarity protein binding ; GO:0005515 | inferred from physical interaction with egg" sperm individualization ; GO:0007291 | inferred from mutant phenotype establishment of mitotic spindle orientation ; GO:0000132 | inferred from mutant phenotype spermatid nucleus elongation ; GO:0007290 | inferred from mutant phenotype microtubule anchoring at centrosome ; GO:0034454 | inferred from mutant phenotype imaginal disc-derived wing morphogenesis ; GO:0007476 | inferred from mutant phenotype spermatogenesis ; GO:0007283 | inferred from mutant phenotype chaeta development ; GO:0022416 | inferred from mutant phenotype wing disc development ; GO:0035220 | inferred from mutant phenotype positive regulation of neuron remodeling ; GO:1904801 | inferred from mutant phenotype microtubule-based movement ; GO:0007018 | inferred from sequence or structural similarity salivary gland cell autophagic cell death ; GO:0035071 | inferred from mutant phenotype neurogenesis ; GO:0022008 | inferred from mutant phenotype oogenesis ; GO:0048477 | inferred from mutant phenotype autophagy ; GO:0006914 | inferred from mutant phenotype chaeta morphogenesis ; GO:0008407 | inferred from mutant phenotype actin filament bundle assembly ; GO:0051017 | inferred from mutant phenotype cytoplasm ; GO:0005737 | inferred from direct assay cytoplasmic dynein complex ; GO:0005868 | inferred from direct assay centriole ; GO:0005814 | inferred from direct assay dynein complex ; GO:0030286 | inferred from direct assay dynein complex ; GO:0030286 | inferred from sequence or structural similarity "ddlc1, dlc, LC8, CG6998, Ddlc-1, Cdlc1, Ddlc1, l(1)G0153, l(1)G0207, l(1)G0204, l(1)G0248, l(1)G0338, l(1)G0387, l(1)G0371, l(1)G0432, l(1)G0445, l(1)G0244, Dlc, anon-WO03040301.128, ctp, Ctp, DLC8, lincRNA.S8635" "IPR001372:Dynein light chain, type 1/2, IPR019763:Dynein light chain, type 1/2, conserved site" CG6998 27-Aug-18 DroID_v2018_08 "Drer\dynll2a, Drer\dnal4a, Drer\dynll2b, Drer\dynll1, Drer\dnal4b" Scer\DYN2 "Cele\dlc-4, Cele\dlc-1, Cele\dlc-2, Cele\dlc-3, Cele\dlc-5" "Xtro\dynll2, Xtro\dnal4, Xtro\dynll1" "Mmus\Dynll2, Mmus\Dnal4, Mmus\Dynll1, Mmus\BC048507" "Hsap\DNAL4, Hsap\DYNLL1, Hsap\DYNLL2" " embryonic stage | late , adult stage && oogenesis stage | stage >S10 , adult stage && oogenesis stage , embryonic stage -- adult stage , pupal stage , adult stage , embryonic stage " " chordotonal organ

, oocyte

, nurse cell

, embryonic central nervous system

, head

,

ubiquitous " " embryonic stage , oogenesis stage "

ubiquitous "viable,female sterile,visible,behavior defective,lethal - all die before end of embryonic stage,some die during embryonic stage,lethal,heat sensitive,recessive,partially lethal - majority live,male sterile,male fertile,poor,lethal - all die before end of P-stage,some die during pharate adult stage,lethal - all die before end of larval stage,some die during larval stage,partially lethal - majority die,locomotor behavior defective,lethal - all die before end of pupal stage,some die during pupal stage,male semi-sterile,partially,wild-type,neuroanatomy defective,mitotic cell cycle defective,increased cell death" "scutum & macrochaeta,scutum & microchaeta,head & macrochaeta,macrochaeta,wing,wing vein,spermatid cyst,seminal vesicle,spermatozoon,spermatocyte fusome,wing & macrochaeta,ovariole,egg chamber,cystic bulge,actin filament bundle & nucleus,actin filament & spermatid,chaeta,salivary gland,lysosome | pupal stage,NMJ bouton,spermatid,nucleus & spermatid,scutum & macrochaeta & embryo,scutum & microchaeta & embryo,embryonic head & macrochaeta,leg & macrochaeta & embryo,sensory neuron,prothoracic femoral chordotonal organ & axon & pupa,longitudinal connective,commissure,prothoracic femoral chordotonal organ & axon,mesothoracic femoral chordotonal organ & axon,metathoracic femoral chordotonal organ & axon,astral microtubule,embryonic/larval neuroblast,astral microtubuleJC70),synaptonemal complex | somatic clone,somatic clone,ganglion mother cell,trichogen cell,tormogen cell,posterior compartment,wing disc" DRSC18758 IEK -2.163120436 -2.113667213 -1.500222659 -0.219841598 1.654270586 0.277847269 FBgn0022734 l(1)3Ai lethal (1) 3Ai http://flybase.org/reports/FBgn0022734 - gene - - - "l[4], l(1)3Ai" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" polytene chromosome FBgn0037001 ND-39 NADH dehydrogenase (ubiquinone) 39 kDa subunit http://flybase.org/reports/FBgn0037001 protein_coding_gene coenzyme binding ; GO:0050662 | inferred from electronic annotation with InterPro:IPR001509 NADH dehydrogenase activity ; GO:0003954 | inferred from sequence or structural similarity with UniProtKB:Q16795 NADH dehydrogenase activity ; GO:0003954 | inferred from biological aspect of ancestor with PANTHER:PTN000252522 "ubiquinone-6 biosynthetic process ; GO:1901006 | inferred from biological aspect of ancestor with PANTHER:PTN000252522 mitochondrial electron transport, NADH to ubiquinone ; GO:0006120 | inferred from sequence or structural similarity with UniProtKB:Q16795" mitochondrial respiratory chain complex I ; GO:0005747 | inferred from sequence or structural similarity with UniProtKB:Q16795 "CG6020, GM13757p, NDUFA9, NUEM, ND-39, Ndufa9" "IPR001509:NAD-dependent epimerase/dehydratase, IPR016040:NAD(P)-binding domain" CG6020 27-Aug-18 DroID_v2018_08 Drer\ndufa9a - Cele\Y53G8AL.2 Xtro\ndufa9 Mmus\Ndufa9 Hsap\NDUFA9 "viable,visible" "trichogen cell,mesothoracic tergum" FBgn0267548 lncRNA:CR45888 - http://flybase.org/reports/FBgn0267548 non_protein_coding_gene - - - CR45888 - CR45888 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0016884 l(2)39DEi lethal (2) 39DEi http://flybase.org/reports/FBgn0016884 - gene - - - "D241, l(2)39DEi" - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0267294 lncRNA:CR45730 - http://flybase.org/reports/FBgn0267294 non_protein_coding_gene - - - CR45730 - CR45730 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0032475 Sfmbt Scm-related gene containing four mbt domains http://flybase.org/reports/FBgn0032475 protein_coding_gene zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR012313 protein binding ; GO:0005515 | inferred from physical interaction with Scm methylated histone binding ; GO:0035064 | inferred from direct assay chromatin binding ; GO:0003682 | inferred from direct assay chromatin silencing ; GO:0006342 | inferred from direct assay imaginal disc growth ; GO:0007446 | inferred from mutant phenotype oogenesis ; GO:0048477 | inferred from mutant phenotype negative regulation of gene expression ; GO:0010629 | inferred from mutant phenotype chromatin silencing ; GO:0006342 | inferred from genetic interaction with Scm PcG protein complex ; GO:0031519 | inferred from physical interaction with pho nucleus ; GO:0005634 | inferred from direct assay "Sfmbt, SFMBT, dSfmbt, CG16975, dSFMBT" "IPR001660:Sterile alpha motif domain, IPR004092:Mbt repeat, IPR012313:Zinc finger, FCS-type, IPR013761:Sterile alpha motif/pointed domain" CG16975 27-Aug-18 DroID_v2018_08 "Drer\mbtd1, Drer\l3mbtl2" - "Cele\lin-61, Cele\mbtr-1" Xtro\mbtd1 "Mmus\Mbtd1, Mmus\L3mbtl2" "Hsap\MBTD1, Hsap\L3MBTL2" "tumorigenic,lethal - all die before end of larval stage,some die during third instar larval stage,lethal" "imaginal disc,female germline stem cell" FBgn0024555 flfl falafel http://flybase.org/reports/FBgn0024555 FBgn0038169 protein_coding_gene protein binding ; GO:0005515 | inferred from physical interaction with mira phagocytosis ; GO:0006909 | inferred from mutant phenotype neuroblast proliferation ; GO:0007405 | inferred from mutant phenotype DNA repair ; GO:0006281 | inferred from mutant phenotype asymmetric neuroblast division ; GO:0055059 | inferred from mutant phenotype asymmetric protein localization ; GO:0008105 | inferred from mutant phenotype "protein phosphatase 4 complex ; GO:0030289 | inferred from direct assay chromosome, centromeric region ; GO:0000775 | inferred from physical interaction with Cenp-C nucleus ; GO:0005634 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay CENP-A containing nucleosome ; GO:0043505 | colocalizes_with inferred from direct assay" "CG9351, l(3)L4179, flfl, PP4R3, Ppp4R3, Flfl" "IPR006887:Domain of unknown function DUF625, IPR016024:Armadillo-type fold, IPR011989:Armadillo-like helical, IPR011993:PH domain-like" CG9351 27-Aug-18 DroID_v2018_08 "Drer\ppp4r3b, Drer\smek1" Scer\PSY2 Cele\smk-1 "Xtro\ppp4r3b, Xtro\ppp4r3a" "Mmus\Smek1, Mmus\4930415L06Rik, Mmus\Smek2, Mmus\4932429P05Rik" "Hsap\PPP4R3A, Hsap\PPP4R3B" "viable,fertile,lethal,recessive,female fertile,poor,visible,partially lethal - majority die,some die during pupal stage,lethal - all die before end of P-stage,some die during pharate adult stage,lethal - all die before end of larval stage,some die during third instar larval stage,decreased cell number,some die during larval stage,cell cycle defective" "wing,wing vein,mesothoracic tergum,neuroblast,cell" DRSC16474 IE -0.95830043 -2.070318391 -0.746483781 -3.562944432 0.019560106 0.750596516 FBgn0040080 pins partner of inscuteable http://flybase.org/reports/FBgn0040080 protein_coding_gene protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:P20353 protein binding ; GO:0005515 | inferred from physical interaction with Gαi inferred from physical interaction with mud GDP-dissociation inhibitor activity ; GO:0005092 | inferred from direct assay protein domain specific binding ; GO:0019904 | inferred from physical interaction with cno regulation of G-protein coupled receptor protein signaling pathway ; GO:0008277 | inferred from electronic annotation with InterPro:IPR024804 asymmetric cell division ; GO:0008356 | inferred from direct assay establishment of mitotic spindle orientation ; GO:0000132 | inferred from mutant phenotype asymmetric protein localization involved in cell fate determination ; GO:0045167 | traceable author statement asymmetric cell division ; GO:0008356 | inferred from mutant phenotype asymmetric neuroblast division ; GO:0055059 | inferred from mutant phenotype maintenance of protein location ; GO:0045185 | non-traceable author statement basal protein localization ; GO:0045175 | traceable author statement neuroblast fate determination ; GO:0007400 | traceable author statement establishment of spindle orientation ; GO:0051294 | inferred from mutant phenotype asymmetric cell division ; GO:0008356 | traceable author statement asymmetric protein localization ; GO:0008105 | traceable author statement establishment of mitotic spindle localization ; GO:0040001 | traceable author statement neuroblast proliferation ; GO:0007405 | inferred from mutant phenotype establishment of mitotic spindle orientation ; GO:0000132 | inferred from direct assay apical cortex ; GO:0045179 | traceable author statement apical cortex ; GO:0045179 | inferred from direct assay cell cortex ; GO:0005938 | traceable author statement cell cortex ; GO:0005938 | inferred from direct assay apical part of cell ; GO:0045177 | non-traceable author statement "pins, Pins, PINS, CG5692, rapsyn, rad, Rad, raps, Raps" "IPR003109:GoLoco motif, IPR011990:Tetratricopeptide-like helical domain, IPR013026:Tetratricopeptide repeat-containing domain, IPR019734:Tetratricopeptide repeat, IPR024804:G-protein-signalling modulator 1" CG5692 27-Aug-18 DroID_v2018_08 "Drer\ogt.1, Drer\gpsm2, Drer\LOC558761, Drer\gpsm1a, Drer\gpsm2l, Drer\gpsm1b" - Cele\ags-3 "Xtro\ttc28, Xtro\gpsm2, Xtro\gpsm1" "Mmus\Ttc24, Mmus\Pcp2, Mmus\Gpsm2, Mmus\Gpsm1, Mmus\Gpsm3" "Hsap\GPSM3, Hsap\PCP2, Hsap\TTC28, Hsap\GPSM1, Hsap\GPSM2" embryonic stage " neuroblast

, mitotic domain 9

" "viable,visible,mitotic cell cycle defective,neuroanatomy defective,cell polarity defective,tumorigenic,cell cycle defective,lethal - all die before end of pupal stage,recessive,some die during pupal stage" "ganglion mother cell GMC4-2a,tormogen cell,mitotic domain 9 & spindle,RP2 motor neuron,ectopic,RP2sib neuron,neuroblast,mitotic cell cycle & spindle,embryonic neuroblast & spindle,centrosome,larval brain & neuroblast,mitotic domain 9 & epithelial cell,spindle,aster,spindle & larval neuroblast,embryonic/larval neuroblast,spindle & external sensory organ precursor cell I,embryonic neuroblast,wing margin,intersegmental nerve,anterior fascicle & synapse,anterior fascicle & synapse | supernumerary" FBgn0024662 l(2)k06501 lethal (2) k06501 http://flybase.org/reports/FBgn0024662 - gene - - - "65/1, l(2)k06501" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" imaginal disc FBgn0261430 CR42647 - http://flybase.org/reports/FBgn0261430 non_protein_coding_gene - - - "CR42647, CR41487" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0022304 l(1)L48.3 lethal (1) L48.3 http://flybase.org/reports/FBgn0022304 - gene - - - "L48.3, l(1)L48.3" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0053286 CG33286 - http://flybase.org/reports/FBgn0053286 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG12982, CG33286" "IPR022110:Casc1 domain, IPR031826:Cancer susceptibility candidate 1, N-terminal" CG33286 27-Aug-18 DroID_v2018_08 Drer\casc1 - Cele\K09E2.2 - Mmus\Casc1 Hsap\CASC1 viable DRSC26119 K 0.267726939 0.083941492 0.491397888 0.335642288 2.721093434 1.641308951 FBgn0014919 anon-72ABc anon-72ABc http://flybase.org/reports/FBgn0014919 - gene - - - anon-72ABc - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0015317 U2af35 U2 small nuclear riboprotein auxiliary factor 35 http://flybase.org/reports/FBgn0015317 FBgn0012029 gene - "mRNA splicing, via spliceosome ; GO:0000398 | inferred from direct assay" nucleoplasm ; GO:0005654 | inferred from direct assay "U2AF-35kDa, U2AF, U2AF[35], U2af35" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0030102 SmydA-9 "SET and MYND domain containing, arthropod-specific, member 9" http://flybase.org/reports/FBgn0030102 protein_coding_gene histone deacetylase binding ; GO:0042826 | inferred from sequence or structural similarity with Smyd4-2 negative regulation of gene expression ; GO:0010629 | inferred from sequence or structural similarity with Smyd4-2 nucleus ; GO:0005634 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay "lincRNA.971, SmydA-9, CG12119" IPR001214:SET domain CG12119 27-Aug-18 DroID_v2018_08 "Drer\smyd1b, Drer\smyd4, Drer\smyd1a, Drer\smyd3, Drer\smyd2b, Drer\smyd2a" "Scer\SET5, Scer\SET6" "Cele\set-10, Cele\set-18, Cele\set-14" "Xtro\smyd4, Xtro\smyd1, Xtro\smyd5" "Mmus\Smyd2, Mmus\Smyd5, Mmus\Smyd3, Mmus\Smyd1, Mmus\Smyd4" "Hsap\SMYD2, Hsap\SMYD4, Hsap\SMYD3, Hsap\SMYD5, Hsap\SMYD1" "viable,fertile" FBgn0016977 spen split ends http://flybase.org/reports/FBgn0016977 "FBgn0010537, FBgn0016056, FBgn0016624, FBgn0022059, FBgn0022080, FBgn0022115, FBgn0026182, FBgn0031230, FBgn0040065, FBgn0047291, FBtr0078121, FBpp0077780, FBtr0078122, FBpp0077781, FBtr0078123, FBpp0077782" protein_coding_gene nucleic acid binding ; GO:0003676 | inferred from biological aspect of ancestor with PANTHER:PTN000573351 "transcription, DNA-templated ; GO:0006351 | inferred from mutant phenotype segment specification ; GO:0007379 | inferred from mutant phenotype establishment of thoracic bristle planar orientation ; GO:0048106 | inferred from mutant phenotype imaginal disc-derived wing vein morphogenesis ; GO:0008586 | inferred from mutant phenotype defense response to fungus ; GO:0050832 | inferred from mutant phenotype wing disc pattern formation ; GO:0035222 | inferred from mutant phenotype axon guidance ; GO:0007411 | inferred from mutant phenotype sleep ; GO:0030431 | inferred from expression pattern epidermal growth factor receptor signaling pathway ; GO:0007173 | inferred from mutant phenotype maintenance of imaginal disc-derived wing hair orientation ; GO:0035321 | inferred from mutant phenotype Wnt signaling pathway ; GO:0016055 | inferred from mutant phenotype compound eye development ; GO:0048749 | inferred from mutant phenotype peripheral nervous system development ; GO:0007422 | inferred from mutant phenotype regulation of transcription, DNA-templated ; GO:0006355 | inferred from mutant phenotype mRNA splicing, via spliceosome ; GO:0000398 | inferred from biological aspect of ancestor with PANTHER:PTN000573351 glial cell fate determination ; GO:0007403 | inferred from mutant phenotype positive regulation of Wnt signaling pathway ; GO:0030177 | inferred from genetic interaction with arm inferred from genetic interaction with hid inferred from genetic interaction with wg neuroblast fate determination ; GO:0007400 | inferred from mutant phenotype" nucleus ; GO:0005634 | inferred from direct assay "Splitends, CG18497, rno, EK2-9, E(Sev-CycE)2A, EY2-7, spe, E(E2F)2A, l(2)k08102, l(2)k07612, l(2)k06805, l(2)03350, poc, 136/24, yip1, En(yan[ACT])2-7, E(Raf)2A, BcDNA:GM01870, spen, SPEN, Spen" "IPR000504:RNA recognition motif domain, IPR010912:Spen paralogue/orthologue C-terminal, metazoa, IPR012921:Spen paralogue and orthologue SPOC, C-terminal, IPR016194:SPOC-like, C-terminal domain, IPR034174:SHARP, RNA recognition motif 3, IPR015943:WD40/YVTN repeat-like-containing domain, IPR034175:SHARP, RNA recognition motif 4, IPR034173:SHARP, RNA recognition motif 2" CG18497 27-Aug-18 DroID_v2018_08 "Drer\spen, Drer\rbm15b, Drer\wu:fb69f10, Drer\rbm15" "Scer\MRN1, Scer\NRD1" "Cele\din-1, Cele\cec-8" "Xtro\rbm15, Xtro\rbm15b" "Mmus\Spen, Mmus\Rbm15b, Mmus\Rbm15" "Hsap\RBM15B, Hsap\RBM15, Hsap\SPEN" " embryonic stage | 0-24 hr , embryonic stage , embryonic stage | 2-24 hr " " embryonic stage | stage 9-14 , embryonic stage , embryonic stage | stage >=3 , larval stage " " embryonic central nervous system

, embryonic epidermis

, organism

, eye disc

, ventral thoracic disc

, dorsal mesothoracic disc

" "lethal,recessive,immune response defective,wound healing defective,viable,fertile,visible,neuroanatomy defective,cell polarity defective,somatic clone,lethal - all die before end of pupal stage,some die during pupal stage" "ommatidium,eye photoreceptor cell,hemocyte,plasmatocyte,crystal cell,macrochaeta,scutellar bristle,ectopic,dorsocentral bristle,tormogen cell,embryonic/larval central nervous system,neurite | pharate adult stage,midline glial cell,commissure,longitudinal connective,central nervous system,presumptive embryonic/larval peripheral nervous system,germline clone,presumptive embryonic/larval central nervous system,abdominal lateral pentascolopidial chordotonal organ lch5,intersegmental nerve,transverse nerve,abdominal segmental nerve,wing vein,somatic clone,crossvein,wing hair,wing margin bristle,microchaeta,head & cuticle | ectopic,embryonic thorax,embryonic thorax & cuticle,embryonic head,hypostomal sclerite,lch5 neuron,ventral midline,ventral nerve cord commissure,motor neuron,embryonic/larval somatic muscle,sclerite,embryonic mesothoracic segment & sclerite | ectopic,embryonic metathoracic segment & sclerite | ectopic,sclerite & embryonic abdominal segment | ectopic,mouth hooks,median tooth,dental sclerite,epipharyngeal sclerite,dorsal bridge,lateral process,embryonic epidermis,sclerite & embryonic head,chordotonal organ & axon | lateral,ventral thoracic disc,denticle belt,embryonic/first instar larval cuticle,eye,mesothoracic tergum,trichogen cell" FBgn0001079 fu fused http://flybase.org/reports/FBgn0001079 - protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 protein serine/threonine kinase activity ; GO:0004674 | inferred from direct assay protein binding ; GO:0005515 | inferred from physical interaction with cos protein serine/threonine kinase activity ; GO:0004674 | non-traceable author statement protein serine/threonine kinase activity ; GO:0004674 | inferred from sequence or structural similarity" "protein phosphorylation ; GO:0006468 | inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR008271 smoothened signaling pathway ; GO:0007224 | traceable author statement smoothened signaling pathway ; GO:0007224 | inferred from mutant phenotype germarium-derived egg chamber formation ; GO:0007293 | inferred from mutant phenotype regulation of protein stability ; GO:0031647 | inferred from direct assay positive regulation of hh target transcription factor activity ; GO:0007228 | inferred from mutant phenotype inferred from genetic interaction with hh positive regulation of protein ubiquitination ; GO:0031398 | inferred from mutant phenotype regulation of proteolysis ; GO:0030162 | non-traceable author statement positive regulation of transcription factor import into nucleus ; GO:0042993 | inferred from mutant phenotype segment polarity determination ; GO:0007367 | inferred from mutant phenotype germarium-derived egg chamber formation ; GO:0007293 | non-traceable author statement intraciliary transport ; GO:0042073 | inferred from mutant phenotype negative regulation of BMP signaling pathway ; GO:0030514 | inferred from genetic interaction with tkv inferred from genetic interaction with Dad protein phosphorylation ; GO:0006468 | non-traceable author statement" membrane ; GO:0016020 | inferred from direct assay protein complex ; GO:0043234 | inferred from physical interaction with Su(fu) Hedgehog signaling complex ; GO:0035301 | inferred from physical interaction with cos inferred from physical interaction with ci "fu, Fu, CG6551, fu[mel], Dm fu, l(1)fu, FU, dFu" "IPR000719:Protein kinase domain, IPR008271:Serine/threonine-protein kinase, active site, IPR011009:Protein kinase-like domain, IPR017441:Protein kinase, ATP binding site" CG6551 27-Aug-18 DroID_v2018_08 "Drer\stk36, Drer\ulk4" Scer\ATG1 Cele\F32D8.1 "Xtro\ulk4, Xtro\stk36" "Mmus\Ulk4, Mmus\Stk36" "Hsap\STK36, Hsap\ULK4" " adult stage , adult stage | female , embryonic stage | <= stage 11 , embryonic stage | early , larval stage " " egg chamber | subset

, organism

,

ubiquitous , germarium region 2

, imaginal disc

" adult stage " germarium region 2

, egg chamber | subset

" "visible,recessive,viable,female fertile,reduced,wild-type,tumorigenic,lethal,rescuable maternal effect,lethal - all die before end of embryonic stage,maternal effect,some die during embryonic stage,lethal - all die before end of pupal stage,some die during pupal stage,female semi-sterile,germline clone,lethal - all die before end of P-stage,some die during pharate adult stage,female sterile,somatic clone,segment polarity phenotype,hyperplasia,heat sensitive" "wing,anterior compartment,sensillum campaniformium,ectopic,wing vein,1st posterior cell,double row,wing vein L3,wing vein L4,wing basal cell 2,dil cell,egg,germline clone,embryo,ovary,denticle belt,maternal effect,embryonic ventral nervous system,blastoderm embryo,embryonic segment,proximal,Bolwig organ,germline cell,cell non-autonomous,somatic clone,posterior compartment,oocyte,egg chamber,cystoblast,supernumerary,ocellar bristle,interocellar bristle,lateral ocellus,medial ocellus,ovariole,distal,microchaeta & tarsal segment 1,microchaeta & tarsal segment 2,microchaeta & tarsal segment 3,microchaeta & tarsal segment 4,microchaeta & tarsal segment 5,macrochaeta & tarsal segment 5 | distal,mesothoracic tarsal bristle longitudinal row 4,mesothoracic tarsal bristle longitudinal row 3.5,mesothoracic tarsal bristle longitudinal row 1,mesothoracic tarsal bristle longitudinal row 5,mesothoracic tarsal bristle longitudinal row 8,mesothoracic tarsal bristle longitudinal row 2.5,wing sensillum,dorsal double row,ventral double row,sensillum campaniformium of dorsal radius,anterior crossvein,embryonic epidermis,ocellus,anterior scutellar bristle,scutellum,embryonic thorax,embryonic abdomen,interfollicle cell,polar follicle cell,nurse cell,presumptive embryonic/larval central nervous system,posterior cell,wing basal cell 1,posterior scutellar bristle,dorsal hair,segment,posterior,germarium,female germline cell" DRSC20333 I 0.490788449 -2.434819276 0.442541585 0.657667334 -0.476184012 0.097666183 FBgn0001965 Sos Son of sevenless http://flybase.org/reports/FBgn0001965 "FBgn0013235, FBgn0026802" protein_coding_gene DNA binding ; GO:0003677 | inferred from electronic annotation with InterPro:IPR007125 protein heterodimerization activity ; GO:0046982 | inferred from electronic annotation with InterPro:IPR009072 protein binding ; GO:0005515 | inferred from physical interaction with drk Ras guanyl-nucleotide exchange factor activity ; GO:0005088 | inferred from sequence or structural similarity Ras guanyl-nucleotide exchange factor activity ; GO:0005088 | inferred from direct assay Rac guanyl-nucleotide exchange factor activity ; GO:0030676 | inferred from genetic interaction with Rac1 "regulation of Rho protein signal transduction ; GO:0035023 | inferred from electronic annotation with InterPro:IPR000219 negative regulation of G1/S transition of mitotic cell cycle ; GO:2000134 | inferred from mutant phenotype imaginal disc-derived leg morphogenesis ; GO:0007480 | inferred from mutant phenotype tracheal outgrowth, open tracheal system ; GO:0007426 | inferred from mutant phenotype axon midline choice point recognition ; GO:0016199 | inferred from genetic interaction with robo1, Rac1, RhoGAP93B, sli torso signaling pathway ; GO:0008293 | traceable author statement positive regulation of Ras protein signal transduction ; GO:0046579 | inferred by curator from GO:0005088 positive regulation of Rac protein signal transduction ; GO:0035022 | inferred from genetic interaction with Rac1 regulation of cell shape ; GO:0008360 | inferred from mutant phenotype anterior/posterior axis specification, embryo ; GO:0008595 | traceable author statement sevenless signaling pathway ; GO:0045500 | traceable author statement actin filament organization ; GO:0007015 | inferred from mutant phenotype" cytoplasm ; GO:0005737 | inferred from direct assay extrinsic component of cytoplasmic side of plasma membrane ; GO:0031234 | inferred from direct assay "sos, EK2-8, Su(tor)2-2, E(sev)2A, 34Ea, br25, l(2)br24, Sos1, EY2-3, BG:DS00941.4, l(2)34Ea, dSos, l(2)k05224, 2.3, l(2)k06321, dme-SOS, SOS, br24, l(2)br25, l(2)Sos, E(var)189, CG7793, Sos, EC2-5" "IPR000219:Dbl homology (DH) domain, IPR000651:Ras-like guanine nucleotide exchange factor, N-terminal, IPR001849:Pleckstrin homology domain, IPR001895:Ras guanine-nucleotide exchange factors catalytic domain, IPR007125:Histone H2A/H2B/H3, IPR011993:PH domain-like, IPR009072:Histone-fold, IPR019804:Ras guanine-nucleotide exchange factor, conserved site, IPR023578:Ras guanine nucleotide exchange factor domain" CG7793 27-Aug-18 DroID_v2018_08 "Drer\rasgrf2a, Drer\rapgef1a, Drer\si:ch211-234p18.3, Drer\sos2, Drer\LOC797658, Drer\rasgrf2b, Drer\sos1, Drer\rapgef1b" "Scer\BUD5, Scer\LTE1, Scer\CDC25, Scer\YCL068C" "Cele\pxf-1, Cele\sos-1, Cele\Y34B4A.4" "Xtro\rapgef1, Xtro\sos1, Xtro\sos2" "Mmus\Sos2, Mmus\Rapgef6, Mmus\Rasgrf1, Mmus\Sos1, Mmus\Rapgef2, Mmus\Rasgrp2, Mmus\Ralgps2, Mmus\Rasgef1b, Mmus\Rapgef1, Mmus\Rasgrf2" "Hsap\RASGRF2, Hsap\RAPGEF1, Hsap\RASGRP2, Hsap\RASGEF1B, Hsap\SOS2, Hsap\RASGRF1, Hsap\SOS1, Hsap\RAPGEF2" "visible,viable,fertile,recessive,lethal,enhancer of variegation,dominant,wild-type,mitotic cell cycle defective,cell autonomous,somatic clone,lethal - all die before end of embryonic stage,some die during embryonic stage,lethal - all die before end of pupal stage,some die during pupal stage,neuroanatomy defective,terminal phenotype,germline clone,maternal effect,body color defective" "wing,wing vein,photoreceptor cell R7,ommatidium,somatic clone,dorsal air sac primordium,pCC neuron,dMP2 neuron,vMP2 neuron,longitudinal connective,eye,ectopic,macrochaeta,commissure,photoreceptor cell R1,photoreceptor cell R2,photoreceptor cell R3,photoreceptor cell R4,photoreceptor cell R5,photoreceptor cell R6,photoreceptor cell R8,eye disc,cell autonomous,midline crossing tract,embryo,germline clone,maternal effect,wing vein L4,abdominal 1 ventral monoscolopidial chordotonal organ vch1,abdominal 2 ventral monoscolopidial chordotonal organ vch1,abdominal 3 ventral monoscolopidial chordotonal organ vch1,abdominal 4 ventral monoscolopidial chordotonal organ vch1,abdominal 5 ventral monoscolopidial chordotonal organ vch1,abdominal 6 ventral monoscolopidial chordotonal organ vch1,abdominal 7 ventral monoscolopidial chordotonal organ vch1,abdominal 1 lateral pentascolopidial chordotonal organ lch5,abdominal 2 lateral pentascolopidial chordotonal organ lch5,abdominal 3 lateral pentascolopidial chordotonal organ lch5,abdominal 4 lateral pentascolopidial chordotonal organ lch5,abdominal 5 lateral pentascolopidial chordotonal organ lch5,abdominal 6 lateral pentascolopidial chordotonal organ lch5,abdominal 7 lateral pentascolopidial chordotonal organ lch5,chaeta,supernumerary,trichogen cell,mesothoracic tergum" DRSC03439 IEK -2.867508031 -6.526072224 -3.167020634 -3.67134216 -1.435347178 -2.484029732 FBgn0001033 Fs(3)Dam Female sterile (3) Damasa http://flybase.org/reports/FBgn0001033 - gene - embryo development ending in birth or egg hatching ; GO:0009792 | inferred from mutant phenotype - "Dam, Fs(3)Damasa, Fs(3)Sz7, Fs(3)Dam" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of embryonic stage,maternal effect,some die during embryonic stage" FBgn0264364 CG43816 - http://flybase.org/reports/FBgn0264364 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG43816 - CG43816 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0028994 saguaro saguaro http://flybase.org/reports/FBgn0028994 gene - dendrite morphogenesis ; GO:0048813 | inferred from mutant phenotype - saguaro - - 27-Aug-18 DroID_v2018_08 - - - - - - dendrite | dorsal | embryonic stage FBgn0266228 lncRNA:CR44923 - http://flybase.org/reports/FBgn0266228 non_protein_coding_gene - - - "CR44923, lincRNA.672" - CR44923 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0259941 ttd5 TRPL translocation defect 5 http://flybase.org/reports/FBgn0259941 protein_coding_gene - - - ttd5 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0002999 omm ommatoreductum http://flybase.org/reports/FBgn0002999 - gene - - - omm - - 27-Aug-18 DroID_v2018_08 - - - - - - "viable,fertile,visible,recessive" "ommatidium,eye,adult head,head bristle,maxillary palpus,macrochaeta & adult thorax,wing" FBgn0260271 GSd466 - http://flybase.org/reports/FBgn0260271 gene - - - GSd466 - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0024353 H217 H217 http://flybase.org/reports/FBgn0024353 - gene - - - H217 - - 27-Aug-18 DroID_v2018_08 - - - - - - "viable,neuroanatomy defective,recessive" "optic lobe,medulla neuropil,medulla,proximal,lamina,distal,lobula plate" FBgn0010341 Cdc42 Cdc42 http://flybase.org/reports/FBgn0010341 FBgn0012059 protein_coding_gene "GTP binding ; GO:0005525 | inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR003578, InterPro:IPR005225 protein binding ; GO:0005515 | inferred from physical interaction with Whamy protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q9W1B0 GTPase activity ; GO:0003924 | non-traceable author statement protein kinase binding ; GO:0019901 | inferred from physical interaction with mbt protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q9VXE5 GTPase activity ; GO:0003924 | inferred from sequence or structural similarity GTPase activity ; GO:0003924 | inferred from direct assay GTPase activating protein binding ; GO:0032794 | inferred from physical interaction with RacGAP84C GTPase activity ; GO:0003924 | traceable author statement protein kinase binding ; GO:0019901 | inferred from physical interaction with Pak3" "positive regulation of wound healing=0090303 |... mutant phenotype <> maintenance of protein location=0045185 |... mutant phenotype <> protein localization to plasma membrane=0072659 |... mutant phenotype <> Rho protein signal transduction=0007266 |... genetic interaction with Zir <> branching involved in open tracheal system development=0060446 |... mutant phenotype <> dendrite morphogenesis=0048813 |... mutant phenotype <> actin filament polymerization=0030041 |... mutant phenotype <> JNK cascade=0007254 | traceable author statement <> regulation of actin filament polymerization=0030833 |... mutant phenotype <> encapsulation of foreign target=0035010 |... mutant phenotype <> axon guidance=0007411 |... mutant phenotype <> actin filament polymerization=0030041 | traceable author statement <> dorsal closure=0007391 | traceable author statement <> establishment of neuroblast polarity=0045200 |... mutant phenotype <> phagocytosis=0006909 |... mutant phenotype <> maintenance of cell polarity=0030011 |... mutant phenotype <> melanotic encapsulation of foreign target=0035011 |... mutant phenotype <> axonogenesis=0007409 | traceable author statement <> regulation of cell shape=0008360 |... mutant phenotype <> actin filament organization=0007015 |... mutant phenotype <> nephrocyte filtration=0097206 |... mutant phenotype <> regulation of glucose metabolic process=0010906 |... mutant phenotype <> wound healing=0042060 |... mutant phenotype <> cellularization=0007349 | traceable author statement <> dorsal closure=0007391 |... mutant phenotype <> positive regulation of protein kinase activity=0045860 |... mutant phenotype <> transforming growth factor beta receptor signaling pathway=0007179 | traceable author statement <> neuron projection morphogenesis=0048812 |... mutant phenotype <> dorsal closure, amnioserosa morphology change=0046664 | NOT inferred from mutant phenotype <> germarium-derived egg chamber formation=0007293 |... mutant phenotype <> suture of dorsal opening=0007396 | traceable author statement <> epithelium development=0060429 |... mutant phenotype <> actin cytoskeleton reorganization=0031532 |... mutant phenotype <> cortical actin cytoskeleton organization=0030866 |... mutant phenotype <> regulation of actin filament polymerization=0030833 |... direct assay <> sensory perception of touch=0050975 |... mutant phenotype <> oogenesis=0048477 | traceable author statement <> cytoskeleton organization=0007010 | non-traceable author statement <> axon extension=0048675 |... genetic interaction with Frl <> cell projection assembly=0030031 |... mutant phenotype <> ovarian follicle cell development=0030707 | traceable author statement <> positive regulation of lamellipodium assembly=0010592 |... mutant phenotype <> spermatid development=0007286 |... mutant phenotype <> regulation of synaptic growth at neuromuscular junction=0008582 |... direct assay <> positive regulation of filopodium assembly=0051491 |... mutant phenotype <> neuromuscular synaptic transmission=0007274 |... genetic interaction with cv-c inferred from genetic interaction with Dys <> regulation of synaptic growth at neuromuscular junction=0008582 |... mutant phenotype <> vesicle-mediated transport=0016192 |... mutant phenotype <> dorsal appendage formation=0046843 |... mutant phenotype <> imaginal disc-derived wing hair outgrowth=0035318 |... mutant phenotype <> motor neuron axon guidance=0008045 |... mutant phenotype <> hemocyte migration=0035099 |... mutant phenotype <> actin cytoskeleton organization=0030036 | traceable author statement <> regulation of axonogenesis=0050770 |... genetic interaction with LIMK1 <> exocyst localization=0051601 |... mutant phenotype <> neuron projection development=0031175 |... mutant phenotype" rhabdomere ; GO:0016028 | inferred from mutant phenotype axon ; GO:0030424 | inferred from direct assay adherens junction ; GO:0005912 | inferred from direct assay cell cortex ; GO:0005938 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay growth cone ; GO:0030426 | inferred from direct assay apical part of cell ; GO:0045177 | inferred from direct assay "DmCDC42, cdc42, Dcdc42, Dm Cdc42, DCdc42, CDC42, DCDC42, Cdc42Dm, D-CDC42, D-Cdc42, Dmcdc42, CG12530, Cdc42, D-cdc42, P40793" "IPR001806:Small GTPase superfamily, IPR005225:Small GTP-binding protein domain, IPR003578:Small GTPase superfamily, Rho type, IPR027417:P-loop containing nucleoside triphosphate hydrolase" CG12530 27-Aug-18 DroID_v2018_08 "Drer\rac3b, Drer\rhogd, Drer\rhoac, Drer\rhoab, Drer\cdc42l2, Drer\rnd3a, Drer\rhogc, Drer\rhobtb2a, Drer\LOC100331257, Drer\rhoq, Drer\rac1b, Drer\rac1a, Drer\cdc42, Drer\rhoj, Drer\rhof, Drer\rhoh, Drer\rhobtb2b, Drer\si:dkey-263f15.2, Drer\rhobtb1, Drer\rnd3b, Drer\rac3a, Drer\rnd1a, Drer\rnd2, Drer\rhoub, Drer\si:dkey-6b12.5, Drer\cdc42l, Drer\rhoca, Drer\si:ch211-133l11.10, Drer\rhogb, Drer\LOC100537765, Drer\rhov, Drer\rhocb, Drer\rhoga, Drer\rac1l, Drer\rhoua, Drer\rhoaa, Drer\rnd1b" "Scer\RHO2, Scer\RHO4, Scer\RHO3, Scer\RHO1, Scer\CDC42, Scer\RHO5" "Cele\crp-1, Cele\mig-2, Cele\ced-10, Cele\cdc-42" "Xtro\rhoa, Xtro\rhoa.2, Xtro\rhof, Xtro\rnd3, Xtro\rhobtb2, Xtro\rac2, Xtro\rhobtb1, Xtro\rnd1, Xtro\rhou, Xtro\rac1, Xtro\cdc42, Xtro\rhoj, Xtro\rhoc, Xtro\rhob, Xtro\rhov, Xtro\rhobtb3" "Mmus\Rac1, Mmus\4930544G11Rik, Mmus\Rac3, Mmus\Rhof, Mmus\Rhob, Mmus\Rhoh, Mmus\Rhoj, Mmus\Rhobtb2, Mmus\Rnd2, Mmus\Rhoc, Mmus\Rhobtb1, Mmus\Rhog, Mmus\Rnd3, Mmus\Rhod, Mmus\Rhou, Mmus\Rnd1, Mmus\Rhobtb3, Mmus\Rhov, Mmus\Rhoa, Mmus\Cdc42, Mmus\Rhoq, Mmus\Rac2" "Hsap\RHOC, Hsap\RND3, Hsap\RHOJ, Hsap\RND1, Hsap\RHOBTB1, Hsap\RHOH, Hsap\CDC42, Hsap\RAC2, Hsap\RHOD, Hsap\RHOU, Hsap\RHOBTB3, Hsap\RHOQ, Hsap\RHOB, Hsap\RHOBTB2, Hsap\RHOG, Hsap\RAC1, Hsap\RHOA, Hsap\RAC3, Hsap\RHOV, Hsap\RND2, Hsap\RHOF" " embryonic stage | stage 10-12 , embryonic stage , embryonic stage | blastoderm , embryonic stage -- adult stage " " somatic mesoderm

, embryonic central nervous system

, embryonic/larval digestive system

,

ubiquitous " "male sterile,wild-type,visible,lethal,recessive,cell shape defective,planar polarity defective,somatic clone,wound healing defective,lethal - all die before end of embryonic stage,maternal effect,partially,some die during embryonic stage,neuroanatomy defective,cell polarity defective,decreased cell size,viable,size defective,immune response defective,non-rescuable maternal effect,lethal - all die before end of pupal stage,some die during pupal stage,touch sensitivity defective,lethal - all die before end of larval stage,some die during larval stage,heat sensitive,female,partially lethal - majority die,neurophysiology defective,chemical sensitive,chemical resistant" "spermatid cyst,seminal vesicle,head cyst cell,actin filamentT155,nurse cell,eye,ommatidium,photoreceptor,pigment cell,rhabdomere,interommatidial bristle,anterior crossvein,ectopic,follicle cell,somatic clone,wing,crossvein,embryo,maternal effect,nurse cell ring canal,germline clone,actin filament | germline clone | maternal effect,vertical system neuron,oocyte,dendrite | ectopic,dendritic spine,axon,terminal tracheal cell,eye photoreceptor cell,retina,embryonic/larval pericardial cell,dorsal closure embryo,embryonic epidermis,ventral,embryonic/first instar larval cuticle,anterior,presumptive embryonic/larval central nervous system,longitudinal connective,embryonic hemocyte,macrophage,nurse cell & actin filament | germ-line clone | maternal effect,proventriculus inner layer primordium,proventriculus intermediate layer primordium,embryonic proventriculus,ganglionic branch primordium,neuroblast,wing hair,supernumerary,actin filament & rhabdomere | somatic clone,neuromuscular junction,bouton,embryonic/larval neuromuscular junction,NMJ bouton,microchaeta & wingptc-559.1,wing disc,anterior/posterior compartment boundary,dorsal,embryonic hemocyte & leading edgePxn.PS, crq.PA,embryonic/larval dorsal trunk,embryonic/larval somatic muscle,myotube,muscle attachment site,microchaeta,wing vein,wing margin,wing margin bristle,heat sensitive,medial triple row,cell non-autonomous,presumptive embryonic/larval tracheal system,antenna & glial cellMz317,antenna & sensory neuronMz317,embryonic/larval midgut | embryonic stage,dorsal appendage,abdominal segmental nerve,neuroblast | embryonic stage,neuromuscular junctionMhc.Switch.PO,dorsal multidendritic neuron ddaA | larval stage,sensory dendrite | larval stage1003.3,neuron,abdominal posterior fascicle neuron & growth cone & filopodiumelav.PLu,mesothoracic les3 neuron & growth cone & filopodiumelav.PLu,metathoracic les3 neuron & growth cone & filopodiumelav.PLu,dendrite | dorsal | embryonic stage60,presumptive embryonic/larval peripheral nervous system,dorsal multidendritic neuron | embryonic stage,dorsal multidendritic neuron & dendrite & embryo60,abdominal intersegmental nerve,dorsal abdominal cluster,dendrite,somatic muscle,antennal commissure,antennal lobe glomerulus,glomerulus,mesothoracic leg disc,aCC neuron & dendriteeve.RN2,RP2 neuron & dendriteeve.RN2,RP2 motor neuron,RP2 neuron & neuriteeve.RN2,RP2 neuron & cell bodyeve.RN2,pCC neuron,dMP2 neuron,vMP2 neuron,midline crossing tract | embryonic stage 16,ventral nerve cord commissure | embryonic stage 16,macrochaeta & metathoracic laterotergiteBx-MS1096,microchaeta & metathoracic laterotergiteBx-MS1096,motor neuron,growth coneelav.PLu,tergal depressor of trochanter muscle motor neuron & dendriteshakB.lethal.4.1,giant fiber neuron,eye disc,growth cone,neurite,giant axon,anterior embryonic/larval midgut,aCC neuron,neuromuscular junctionC57,epithelium,female germline cyst" FBgn0260442 rhea rhea http://flybase.org/reports/FBgn0260442 protein_coding_gene actin filament binding ; GO:0051015 | inferred from electronic annotation with InterPro:IPR006077 structural constituent of cytoskeleton ; GO:0005200 | inferred from electronic annotation with InterPro:IPR015224 insulin receptor binding ; GO:0005158 | inferred from electronic annotation with InterPro:IPR002404 protein binding ; GO:0005515 | inferred from physical interaction with wech actin binding ; GO:0003779 | inferred from sequence or structural similarity integrin binding ; GO:0005178 | inferred from physical interaction with mys "cytoskeletal anchoring at plasma membrane ; GO:0007016 | inferred from electronic annotation with InterPro:IPR015224 cytoskeletal anchoring at plasma membrane ; GO:0007016 | inferred from sequence or structural similarity muscle attachment ; GO:0016203 | inferred from mutant phenotype cardiac muscle cell-cardiac muscle cell adhesion ; GO:0086042 | inferred from mutant phenotype sarcomere organization ; GO:0045214 | inferred from mutant phenotype regulation of cell shape ; GO:0008360 | inferred from mutant phenotype apposition of dorsal and ventral imaginal disc-derived wing surfaces ; GO:0007475 | inferred from mutant phenotype cell adhesion ; GO:0007155 | traceable author statement germ-band shortening ; GO:0007390 | inferred from mutant phenotype cell adhesion mediated by integrin ; GO:0033627 | inferred from mutant phenotype phagocytosis ; GO:0006909 | inferred from mutant phenotype larval somatic muscle development ; GO:0007526 | inferred from mutant phenotype border follicle cell migration ; GO:0007298 | inferred from mutant phenotype trachea morphogenesis ; GO:0060439 | inferred from mutant phenotype cell adhesion ; GO:0007155 | inferred from mutant phenotype terminal branching, open tracheal system ; GO:0007430 | inferred from mutant phenotype negative regulation of transcription, DNA-templated ; GO:0045892 | inferred from mutant phenotype maintenance of epithelial integrity, open tracheal system ; GO:0035160 | inferred from mutant phenotype" cytoskeleton ; GO:0005856 | inferred from electronic annotation with InterPro:IPR000299 ruffle ; GO:0001726 | inferred from electronic annotation with InterPro:IPR015224 focal adhesion ; GO:0005925 | inferred from direct assay focal adhesion ; GO:0005925 | inferred from sequence or structural similarity "rhea, talin, Talin, CG6831, CT21159, Tln, Rhea, tendrils" "IPR029071:Ubiquitin-related domain, IPR006077:Vinculin/alpha-catenin, IPR002558:I/LWEQ domain, IPR015009:Vinculin-binding site-containing domain, IPR019748:FERM central domain, IPR015224:Talin, central, IPR002404:IRS-type PTB domain, IPR019747:FERM conserved site, IPR011993:PH domain-like, IPR014352:FERM/acyl-CoA-binding protein, 3-helical bundle, IPR019749:Band 4.1 domain, IPR018979:FERM, N-terminal, IPR000299:FERM domain, IPR032425:Talin, N-terminal F0 domain" CG6831 27-Aug-18 DroID_v2018_08 "Drer\tln2a, Drer\mesdc1, Drer\tln2b, Drer\tln1" Scer\SLA2 Cele\tln-1 "Xtro\mesdc1, Xtro\tln2" "Mmus\Tln1, Mmus\Tln2, Mmus\Mesdc1" "Hsap\TLN1, Hsap\TLN2, Hsap\MESDC1" " embryonic stage | stage 12 , embryonic stage | stage 6 , embryonic stage | stage 16 " " ventral nervous system

, organism | ubiquitous

, embryonic midgut

, muscle attachment site

" " embryonic stage | stage 12 , larval stage | third instar , embryonic stage | stage 16 , embryonic stage | stage 6 " " anterior midgut proper primordium && posterior midgut proper primordium

, dorsal mesothoracic disc | restricted

, muscle attachment site

,

" "viable,lethal,visible,somatic clone,lethal - all die before end of embryonic stage,recessive,some die during embryonic stage" "egg chamber,conditional,muscle attachment site,germline clone,presumptive embryonic/larval muscle system,muscle cell,tendon cell,muscle cell & actin filament & embryo,tendon cell & microtubule & embryo,muscle cell & focal adhesion & embryo,tendon cell & focal adhesion & embryo,tendon cell & basal lamina & embryo,somatic clone,actin filament & follicle cell | somatic clone,embryonic/larval midgut primordium,embryonic proventriculus,germ band,rescuable maternal effect,terminal tracheal cell,oocyte,cell non-autonomous,gastric caecum primordium,wing,embryonic/larval somatic muscle,eye,embryonic/larval tracheal system,embryonic/larval fat body branch,border follicle cell" FBgn0036483 CG12316 - http://flybase.org/reports/FBgn0036483 protein_coding_gene - "histone H4-K16 acetylation ; GO:0043984 | inferred from electronic annotation with InterPro:IPR026711 male courtship behavior, veined wing generated song production ; GO:0045433 | inferred from mutant phenotype" MSL complex ; GO:0072487 | inferred from electronic annotation with InterPro:IPR026711 CG12316 IPR026711:Protein male-specific lethal-1 CG12316 27-Aug-18 DroID_v2018_08 "Drer\msl1b, Drer\msl1a" - - - Mmus\Msl1 Hsap\MSL1 "song defective,partially lethal - majority die,some die during pupal stage" embryonic/larval hemocyte | third instar larval stage DRSC09879 K 0.23269485 0.430565511 0.046557753 0.788846029 1.687490338 0.010109736 FBgn0000022 ac achaete http://flybase.org/reports/FBgn0000022 - protein_coding_gene "protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with da sequence-specific DNA binding ; GO:0043565 | inferred from direct assay sequence-specific DNA binding ; GO:0043565 | contributes_to inferred from physical interaction with da sequence-specific DNA binding ; GO:0043565 | contributes_to inferred from direct assay transcription factor activity, sequence-specific DNA binding ; GO:0003700 | contributes_to inferred from biological aspect of ancestor with PANTHER:PTN000358347 DNA binding ; GO:0003677 | traceable author statement RNA polymerase II regulatory region sequence-specific DNA binding ; GO:0000977 | inferred from biological aspect of ancestor with PANTHER:PTN000358347 transcription factor activity, sequence-specific DNA binding ; GO:0003700 | inferred from sequence or structural similarity with l(1)sc" "neuroblast fate determination ; GO:0007400 | traceable author statement peripheral nervous system development ; GO:0007422 | inferred from mutant phenotype peripheral nervous system development ; GO:0007422 | traceable author statement positive regulation of transcription, DNA-templated ; GO:0045893 | traceable author statement chaeta morphogenesis ; GO:0008407 | inferred from mutant phenotype central nervous system development ; GO:0007417 | traceable author statement epithelial cell proliferation involved in Malpighian tubule morphogenesis ; GO:0061331 | inferred from mutant phenotype chaeta morphogenesis ; GO:0008407 | non-traceable author statement regulation of neurogenesis ; GO:0050767 | inferred from biological aspect of ancestor with PANTHER:PTN000358354 regulation of transcription, DNA-templated ; GO:0006355 | inferred from sequence or structural similarity with l(1)sc oogenesis ; GO:0048477 | traceable author statement ventral cord development ; GO:0007419 | non-traceable author statement sensory organ development ; GO:0007423 | inferred from mutant phenotype nervous system development ; GO:0007399 | traceable author statement regulation of transcription, DNA-templated ; GO:0006355 | non-traceable author statement regulation of antimicrobial peptide biosynthetic process ; GO:0002805 | inferred from mutant phenotype regulation of transcription from RNA polymerase II promoter ; GO:0006357 | inferred from biological aspect of ancestor with PANTHER:PTN000358347 regulation of glucose metabolic process ; GO:0010906 | inferred from mutant phenotype regulation of mitotic cell cycle ; GO:0007346 | traceable author statement Malpighian tubule tip cell differentiation ; GO:0061382 | inferred from mutant phenotype" nucleus ; GO:0005634 | inferred from direct assay RNA polymerase II transcription factor complex ; GO:0090575 | inferred from biological aspect of ancestor with PANTHER:PTN000358347 transcription factor complex ; GO:0005667 | inferred from physical interaction with da "ac, Hw, Ac, EG:125H10.3, CG3796, 990 E5 F1, T5, AS-C T5, AS-C T5ac, ascT5, sc/T5, ASC, AC, AS-C" "IPR015660:Achaete-scute transcription factor-related, IPR011598:Myc-type, basic helix-loop-helix (bHLH) domain" CG3796 27-Aug-18 DroID_v2018_08 "Drer\ascl1a, Drer\ascl1b" - "Cele\hlh-14, Cele\hlh-4, Cele\hlh-3" Xtro\ascl2 "Mmus\Ascl1, Mmus\Ascl3, Mmus\Ascl2" "Hsap\ASCL2, Hsap\ASCL5, Hsap\ASCL3, Hsap\ASCL4, Hsap\ASCL1" " embryonic stage , larval stage , embryonic stage | stage 9 , larval stage | third instar , embryonic stage | stage 8 " " stomodeum

, neuroblast

, sensory mother cell

, posterior embryonic/larval midgut

, proneural cluster

, embryonic stomatogastric nervous system

, neuroblast

{ $ N* } , neurogenic region

, neurectoderm

{ $ E(spl)* } , sensory organ cell

, dorsal mesothoracic disc | restricted

, ventral midline

, ectoderm

, procephalic segment

, larval optic lobe | presumptive

, procephalic neuroblast

, embryonic central nervous system

, dorsal mesothoracic disc

, neurectoderm

{ $ Dl* } , neurectoderm

{ $ neur* } , cephalic furrow

, embryonic peripheral nervous system

, labral segment

, ventral neurogenic region

, neurectoderm

{ $ bib* } " " larval stage | third instar , larval stage , embryonic stage | stage 9-11 , embryonic stage | stage 8-9 , embryonic stage , embryonic stage | stage 8 , embryonic stage | stage 8-10 , embryonic stage | stage 8-11 , embryonic stage | stage 9 , wandering third instar larval stage " " dorsal mesothoracic disc

, sensory mother cell

, protocerebral neuroblast | subset

, neuroblast NB3-5

, neurectoderm

{ $ neur* } , proneural cluster

, neurectoderm

{ $ bib* } , neuroblast NB7-4

, wing vein L5

, ectoderm

, deuterocerebral neuroblast | subset

, neuroblast NB7-1

, neuroblast MP2

, procephalic neuroblast | subset

, wing vein L1

{ + h* } , ventral neurogenic region

, wing vein L3

{ + h* } , procephalic neurogenic region | restricted

, neuroblast

{ $ N* } , neurectoderm

{ $ E(spl)* } , neurectoderm

{ $ Dl* } , dorsal mesothoracic disc | dorsal/ventral compartment boundary & restricted " "visible,dominant,recessive,viable,good,wild-type,male sterile,fertile,male fertile,female sterile" "external sensory organ,ectopic,scutellum,wing vein L3,macrochaeta & head,macrochaeta & thorax,sensillum campaniformium,microchaeta,mesothoracic tarsal bristle,mesothoracic metatarsus,macrochaeta,glial cell,wing & nerve,nerve,third segment of antenna,mesothoracic tergum & macrochaeta | ectopic,wing margin bristle,anterior orbital bristle,anterior notopleural bristle,humeral bristle,postvertical bristle,ocellar bristle,presutural bristle,anterior postalar bristle,anterior supraalar bristle,posterior postalar bristle,posterior supraalar bristle,scutellar bristle,dorsocentral bristle,acrostichal bristle,supernumerary,anterior dorsocentral bristle,posterior dorsocentral bristle,microchaeta & mesothoracic pleurum,microchaeta & wing,macrochaeta & abdominal tergite,microchaeta & pleural membrane,interocellar bristle,interommatidial bristle,mesothoracic leg sensillum,posterior notopleural bristle,microchaeta & scutum,microchaeta & scutellum,sensillum campaniformium of proximal dorsal radius,sense organ & wing vein,precursor,macrochaeta & leg,microchaeta & leg,adult thorax & microchaeta,scutum,wing,microchaeta & mesothoracic tergum | supernumerary,neuron,anterior sternopleural bristle,wing vein,posterior crossvein,chaeta,sensory mother cell,sensory mother cell & dorsal mesothoracic disc" DRSC18734 I -1.740211892 -2.639558744 0.435517917 1.190294363 0.396568427 0.114040713 FBgn0026404 Dronc Death regulator Nedd2-like caspase http://flybase.org/reports/FBgn0026404 "FBgn0025326, FBgn0062102" protein_coding_gene cysteine-type endopeptidase activity ; GO:0004197 | traceable author statement cysteine-type endopeptidase activity ; GO:0004197 | inferred from sequence or structural similarity with WB:WBGene00000417 inferred from direct assay cysteine-type endopeptidase activity ; GO:0004197 | inferred from direct assay endopeptidase activity ; GO:0004175 | inferred from direct assay cysteine-type endopeptidase activity involved in apoptotic signaling pathway ; GO:0097199 | inferred from direct assay cysteine-type endopeptidase activity involved in apoptotic signaling pathway ; GO:0097199 | contributes_to inferred from direct assay cysteine-type endopeptidase activity involved in execution phase of apoptosis ; GO:0097200 | inferred from biological aspect of ancestor with PANTHER:PTN000825206 protein homodimerization activity ; GO:0042803 | inferred from direct assay CARD domain binding ; GO:0050700 | inferred from sequence model hemocyte development ; GO:0007516 | inferred from mutant phenotype neuron remodeling ; GO:0016322 | inferred from mutant phenotype positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway ; GO:2001269 | inferred from direct assay programmed cell death involved in cell development ; GO:0010623 | inferred from mutant phenotype neuron remodeling ; GO:0016322 | inferred from mutant phenotype inferred from genetic interaction with Ca-β metamorphosis ; GO:0007552 | traceable author statement programmed cell death ; GO:0012501 | inferred from direct assay salivary gland cell autophagic cell death ; GO:0035071 | inferred from expression pattern ectopic germ cell programmed cell death ; GO:0035234 | inferred from mutant phenotype apoptotic process ; GO:0006915 | traceable author statement head involution ; GO:0008258 | inferred from mutant phenotype embryonic development via the syncytial blastoderm ; GO:0001700 | traceable author statement regulation of retinal cell programmed cell death ; GO:0046668 | non-traceable author statement nurse cell apoptotic process ; GO:0045476 | inferred from genetic interaction with Strica apoptotic process ; GO:0006915 | inferred from mutant phenotype zymogen activation ; GO:0031638 | inferred from direct assay inferred from mutant phenotype embryonic development via the syncytial blastoderm ; GO:0001700 | non-traceable author statement execution phase of apoptosis ; GO:0097194 | inferred from biological aspect of ancestor with PANTHER:PTN000825206 central nervous system development ; GO:0007417 | inferred from mutant phenotype melanization defense response ; GO:0035006 | inferred from mutant phenotype sperm individualization ; GO:0007291 | inferred from mutant phenotype sensory organ development ; GO:0007423 | inferred from mutant phenotype determination of adult lifespan ; GO:0008340 | inferred from mutant phenotype apoptotic process ; GO:0006915 | inferred from mutant phenotype inferred from genetic interaction with Diap1 inferred from physical interaction with Diap1 protein autoprocessing ; GO:0016540 | inferred from direct assay compound eye development ; GO:0048749 | inferred from mutant phenotype negative regulation of cell proliferation ; GO:0008285 | inferred from direct assay regulation of cell death ; GO:0010941 | inferred from mutant phenotype regulation of autophagy ; GO:0010506 | inferred from genetic interaction with Atg1 dendrite morphogenesis ; GO:0048813 | inferred from mutant phenotype positive regulation of compound eye retinal cell programmed cell death ; GO:0046672 | inferred from mutant phenotype apoptotic process ; GO:0006915 | non-traceable author statement activation of cysteine-type endopeptidase activity involved in apoptotic process ; GO:0006919 | inferred from mutant phenotype salivary gland histolysis ; GO:0035070 | inferred from mutant phenotype apoptotic process ; GO:0006915 | inferred from expression pattern inferred from mutant phenotype autophagic cell death ; GO:0048102 | inferred from expression pattern protein heterooligomerization ; GO:0051291 | inferred from direct assay mitochondrion ; GO:0005739 | NOT inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay apoptosome ; GO:0043293 | inferred from direct assay "Dronc, DRONC, dronc, CG8091, caspase-9, anon-EST:GreesD6, anon-EST:GressD6, anon-WO0118547.313, Nc, Dronc/Casp9, CG8090, Nc\Dronc" "IPR001309:Peptidase C14, p20 domain, IPR002138:Peptidase C14, caspase non-catalytic subunit p10, IPR011029:Death-like domain, IPR015917:Peptidase C14A, caspase catalytic domain, IPR017350:Peptidase C14A, interleukin-1 beta convertase type, IPR029030:Caspase-like domain, IPR033139:Peptidase family C14A, cysteine active site" CG8091 27-Aug-18 DroID_v2018_08 "Drer\LOC798445, Drer\casp8l2, Drer\caspb, Drer\casp3b, Drer\caspxa, Drer\pycard, Drer\gbp3, Drer\casp3a, Drer\LOC101886133, Drer\casp8l1, Drer\casp9, Drer\casp2, Drer\caspbl, Drer\cflara, Drer\zgc:194469, Drer\si:ch211-195h23.3, Drer\caspa, Drer\casp7, Drer\pea15, Drer\zgc:171731, Drer\casp8, Drer\si:dkey-103e21.5, Drer\casp6, Drer\LOC100331324" - "Cele\csp-2, Cele\csp-1, Cele\csp-3, Cele\ced-3" "Xtro\casp9, Xtro\casp6, Xtro\casp7, Xtro\LOC733553, Xtro\casp3, Xtro\casp2, Xtro\pea15, Xtro\casp10, Xtro\casp1" "Mmus\Casp4, Mmus\Casp12, Mmus\Casp2, Mmus\Casp14, Mmus\Cflar, Mmus\Casp1, Mmus\Casp8, Mmus\Gpr89, Mmus\Casp3, Mmus\Casp9, Mmus\Pea15a, Mmus\Casp7, Mmus\Casp6" "Hsap\CASP1, Hsap\CASP14, Hsap\CASP10, Hsap\CFLAR, Hsap\CASP9, Hsap\CASP3, Hsap\PEA15, Hsap\GPR89B, Hsap\GPR89A, Hsap\CASP8, Hsap\CARD8, Hsap\CASP5, Hsap\CASP4, Hsap\CASP12, Hsap\CASP2, Hsap\CASP7, Hsap\CARD17, Hsap\CASP6, Hsap\CARD18, Hsap\CARD16" " adult stage && oogenesis stage , embryonic stage -- adult stage , larval stage | third instar , embryonic stage | early " " egg chamber

, eye disc

, embryonic/larval midgut

,

ubiquitous , embryonic/larval salivary gland

, larval brain

" "visible,lethal - all die before end of P-stage,some die during pharate adult stage,eye color defective,lethal - all die before end of pupal stage,temperature conditional,some die during pupal stage,lethal - all die before end of first instar larval stage,some die during first instar larval stage,increased cell death,lethal - all die before end of embryonic stage,decreased cell death,some die during embryonic stage,female sterile,male sterile,partially,partially lethal - majority die,decreased cell number,lethal,recessive,maternal effect,neuroanatomy defective,short lived,cell death defective,developmental rate defective,melanotic necrosis,cell shape defective,viable,fertile,increased cell number,somatic clone,rescuable maternal effect,chemical resistant,size defective,lethal - all die before end of larval stage,some die during larval stage,male,wild-type" "eye,pigment cell,ommatidium,eye disc,temperature conditional,adult head,eye disc | third instar larval stage,spermatid,cystic bulge,waste bag,spermatogonial cyst,male germline cell,eye photoreceptor cell,eye disc | P-stage,embryonic/larval Malpighian tubule,retina,wing,dorsal multidendritic neuron ddaC,dendrite477,posterior,embryonic/larval fat body | wandering third instar larval stage,neuron,inter-ommatidial precursor cell,supernumerary,salivary gland | pupal stage,postalar bristle,dendriteppk.1.9,retinal pigment cell,melanotic mass,embryonic/larval digestive system,somatic clone,eye-antennal disc,eye disc posterior to the morphogenetic furrow,embryonic/larval hemocyte,imaginal disc,embryonic/larval brain,ventral nerve cord primordium,rescuable maternal effect,ventral trunk epidermis primordium,dorsal ridge primordium,Bolwig organ,ventral nerve cord,ommatidial precursor cluster,embryonic/larval midgut,dendrite,imaginal disc epithelial cell,neuron & ventral nerve cord | ectopic,macrochaeta,sensory mother cell,eo neuron,thecogen cell,embryonic head,arista,egg chamber,male genitalia,neuroblast & larval abdominal segment 3 | late third instar larval stage,neuroblast & larval abdominal segment 4 | late third instar larval stage,neuroblast & larval abdominal segment 5 | late third instar larval stage,neuroblast & larval abdominal segment 6 | late third instar larval stage,neuroblast & larval abdominal segment 7 | late third instar larval stage,embryonic/larval salivary gland | P-stage,embryonic/larval neuromuscular junction,midline glial cell,maternal effect,presumptive embryonic/larval central nervous system,scolopidial neuron,peptidergic neuron,ectopic,cell autonomous,germline clone" FBgn0022943 Cbp20 cap binding protein 20 http://flybase.org/reports/FBgn0022943 - protein_coding_gene mRNA binding ; GO:0003729 | inferred from sequence or structural similarity RNA cap binding ; GO:0000339 | inferred from biological aspect of ancestor with PANTHER:PTN000428749 protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q9V9K7 "mRNA cis splicing, via spliceosome ; GO:0045292 | inferred from electronic annotation with InterPro:IPR027157 gene silencing by miRNA ; GO:0035195 | inferred from mutant phenotype primary miRNA processing ; GO:0031053 | inferred from mutant phenotype production of siRNA involved in RNA interference ; GO:0030422 | inferred from mutant phenotype mRNA splicing, via spliceosome ; GO:0000398 | inferred from biological aspect of ancestor with PANTHER:PTN000428749 negative regulation of viral genome replication ; GO:0045071 | inferred from mutant phenotype mRNA splicing, via spliceosome ; GO:0000398 | inferred by curator from GO:0071011,GO:0071013 mRNA splicing, via spliceosome ; GO:0000398 | inferred from sequence or structural similarity with SGD:S000006099 RNA interference ; GO:0016246 | inferred from mutant phenotype" catalytic step 2 spliceosome ; GO:0071013 | inferred from direct assay spliceosomal complex ; GO:0005681 | inferred from sequence or structural similarity with SGD:S000006099 precatalytic spliceosome ; GO:0071011 | inferred from direct assay nuclear cap binding complex ; GO:0005846 | inferred from biological aspect of ancestor with PANTHER:PTN000428749 microtubule associated complex ; GO:0005875 | inferred from direct assay "CG12357, CBP20, Cbp20, cbp20" "IPR000504:RNA recognition motif domain, IPR034148:NCBP2, RNA recognition motif, IPR027157:Nuclear cap-binding protein subunit 2" CG12357 27-Aug-18 DroID_v2018_08 "Drer\ncbp2, Drer\tmem67" Scer\CBC2 "Cele\ncbp-2, Cele\mks-3" "Xtro\ncbp2, Xtro\tmem67" "Mmus\Tmem67, Mmus\Ncbp2" Hsap\NCBP2 "lethal - all die before end of pupal stage,some die during pupal stage" DRSC16601 E -1.373373642 0.163633029 -0.665405551 -2.095003137 -0.705169843 0.013278262 FBgn0086675 fne found in neurons http://flybase.org/reports/FBgn0086675 protein_coding_gene mRNA binding ; GO:0003729 | inferred from sequence or structural similarity poly(U) RNA binding ; GO:0008266 | inferred from direct assay regulation of mRNA processing ; GO:0050684 | inferred from genetic interaction with elav regulation of RNA metabolic process ; GO:0051252 | inferred from mutant phenotype male courtship behavior ; GO:0008049 | inferred from mutant phenotype cytoplasm ; GO:0005737 | inferred from direct assay "fne, CG4396, Fne, cg4396, CR32646, MRE28, BEST:HL02010, BcDNA:RE25290, BcDNA:HL02010, FNE, lincRNA.985" "IPR006548:Splicing factor ELAV/HuD, IPR002343:Paraneoplastic encephalomyelitis antigen, IPR000504:RNA recognition motif domain" CG4396 27-Aug-18 DroID_v2018_08 "Drer\elavl1, Drer\hug, Drer\nol8, Drer\fam213b, Drer\rbms3, Drer\rbms2b, Drer\elavl3, Drer\rbms1a, Drer\elavl2, Drer\rbms2a, Drer\elavl4" "Scer\GBP2, Scer\PAB1" Cele\exc-7 "Xtro\elavl3, Xtro\elavl1, Xtro\elavl2, Xtro\elavl4" "Mmus\Rbms2, Mmus\Fam213b, Mmus\Elavl4, Mmus\Rbms3, Mmus\Elavl1, Mmus\Rbms1, Mmus\Elavl3, Mmus\Elavl2" "Hsap\ELAVL4, Hsap\RBMS2, Hsap\ELAVL2, Hsap\RBMS3, Hsap\ELAVL1, Hsap\FAM213B, Hsap\ELAVL3, Hsap\RBMS1" DRSC20332 IK 0.642261473 -2.601554176 -0.358408268 -0.67421499 -1.500464561 2.034815472 FBgn0039509 bigmax bigmax http://flybase.org/reports/FBgn0039509 protein_coding_gene "protein dimerization activity ; GO:0046983 | inferred from electronic annotation with InterPro:IPR011598 transcription factor binding ; GO:0008134 | inferred from electronic annotation with InterPro:IPR032647 transcription factor activity, sequence-specific DNA binding ; GO:0003700 | inferred from biological aspect of ancestor with PANTHER:PTN001039502" "regulation of transcription from RNA polymerase II promoter ; GO:0006357 | inferred from biological aspect of ancestor with PANTHER:PTN001039502 regulation of glucose metabolic process ; GO:0010906 | inferred from mutant phenotype dendrite morphogenesis ; GO:0048813 | inferred from mutant phenotype muscle organ development ; GO:0007517 | inferred from mutant phenotype salivary gland cell autophagic cell death ; GO:0035071 | inferred from expression pattern adult feeding behavior ; GO:0008343 | inferred from mutant phenotype autophagic cell death ; GO:0048102 | inferred from expression pattern regulation of transcription, DNA-templated ; GO:0006355 | inferred from sequence or structural similarity with Max" nucleus ; GO:0005634 | inferred from biological aspect of ancestor with PANTHER:PTN001039502 "CG3350, DmMlx, BIGMAX, bigmax, Bigmax, Mlx, mlx, bHLHd13, cg3350" "IPR011598:Myc-type, basic helix-loop-helix (bHLH) domain, IPR032647:Max-like protein X" CG3350 27-Aug-18 DroID_v2018_08 Drer\mlx "Scer\HMS1, Scer\RTG3" Cele\mxl-2 Xtro\mlx Mmus\Mlx Hsap\MLX "majority die during pharate adult stage,developmental rate defective,lethal,conditional,viable,fertile,partially lethal" DRSC27542 K -0.293881812 0.676708658 -0.386991031 -0.226091023 -1.549114853 -1.001737909 FBgn0025185 az2 az2 http://flybase.org/reports/FBgn0025185 FBgn0022958 protein_coding_gene "nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR013087 transcription factor activity, sequence-specific DNA binding ; GO:0003700 | inferred from sequence or structural similarity with gl zinc ion binding ; GO:0008270 | inferred from sequence model" "regulation of transcription, DNA-templated ; GO:0006355 | inferred from sequence or structural similarity with gl" cellular_component ; GO:0005575 | no biological data available "zf43C, CG1605, az2" "IPR006578:MADF domain, IPR013087:Zinc finger C2H2-type, IPR013083:Zinc finger, RING/FYVE/PHD-type" CG1605 27-Aug-18 DroID_v2018_08 - - "Cele\mnm-2, Cele\eor-1, Cele\sdz-12" - "Mmus\Gm13212, Mmus\Zfp980, Mmus\Zfp995" "Hsap\ZNF585A, Hsap\ZNF133" " adult stage && oogenesis stage , adult stage | female && oogenesis stage | stage =S10B " " nurse cell

, ovary

, oocyte

" FBgn0262445 mir-133 mir-133 stem loop http://flybase.org/reports/FBgn0262445 miRNA_gene - - - "dme-miR-133, dme-mir-133, miR-133, mir-133, MIR-133, CR43011, CR33574" - CR43011 27-Aug-18 DroID_v2018_08 - - - - - - " embryonic stage , pupal stage " "visible,lethal,lethal - all die before end of embryonic stage,some die during embryonic stage" "eye,wing,wing vein" FBgn0011674 insc inscuteable http://flybase.org/reports/FBgn0011674 "FBgn0010601, FBgn0013468, FBgn0015387" protein_coding_gene protein binding ; GO:0005515 | inferred from physical interaction with corn cytoskeletal adaptor activity ; GO:0008093 | inferred from sequence or structural similarity inferred from mutant phenotype basal protein localization ; GO:0045175 | traceable author statement apical protein localization ; GO:0045176 | inferred from mutant phenotype inferred from physical interaction with corn establishment of mitotic spindle localization ; GO:0040001 | non-traceable author statement peripheral nervous system development ; GO:0007422 | inferred from mutant phenotype asymmetric neuroblast division ; GO:0055059 | traceable author statement protein localization ; GO:0008104 | inferred from mutant phenotype neuroblast fate determination ; GO:0007400 | traceable author statement establishment of mitotic spindle localization ; GO:0040001 | traceable author statement asymmetric neuroblast division ; GO:0055059 | inferred from genetic interaction with Gαi inferred from genetic interaction with pins regulation of asymmetric cell division ; GO:0009786 | inferred from mutant phenotype asymmetric protein localization involved in cell fate determination ; GO:0045167 | non-traceable author statement sensory organ development ; GO:0007423 | traceable author statement asymmetric protein localization involved in cell fate determination ; GO:0045167 | traceable author statement neuroblast fate determination ; GO:0007400 | inferred from direct assay regulation of nervous system development ; GO:0051960 | inferred from mutant phenotype protein localization ; GO:0008104 | non-traceable author statement Malpighian tubule tip cell differentiation ; GO:0061382 | inferred from mutant phenotype defense response to Gram-negative bacterium ; GO:0050829 | inferred from mutant phenotype asymmetric cell division ; GO:0008356 | traceable author statement establishment of mitotic spindle localization ; GO:0040001 | inferred from mutant phenotype somatic muscle development ; GO:0007525 | inferred from mutant phenotype RNA localization ; GO:0006403 | inferred from mutant phenotype asymmetric protein localization ; GO:0008105 | traceable author statement apical cortex ; GO:0045179 | inferred from direct assay apical part of cell ; GO:0045177 | non-traceable author statement apical cortex ; GO:0045179 | traceable author statement cytoplasm ; GO:0005737 | inferred from direct assay cell cortex ; GO:0005938 | inferred from direct assay "insc, Ins, nem, l(2)k12405, l(2)05475, 25/17, fam, CG11312, Insc, INSC" "IPR016024:Armadillo-type fold, IPR011989:Armadillo-like helical" CG11312 27-Aug-18 DroID_v2018_08 - - Cele\insc-1 - Mmus\Insc Hsap\INSC " embryonic stage | 3-12 hr , embryonic stage | stage <=14 , embryonic stage | stage 13-15 , embryonic stage | stage 10 , embryonic stage | stage 9-11 , embryonic stage | stage 10-12 , embryonic stage | stage >=15 , embryonic stage | stage 4 , embryonic stage | 4-20 hr , embryonic stage | stage 11-13 , adult stage , embryonic stage | stage 10-13 , embryonic stage , embryonic stage | stage 6 " " embryonic central nervous system

, embryonic/larval midgut

, ganglion mother cell

, ventral neurogenic region

, posterior midgut proper primordium

, embryonic/larval hindgut

, procephalic neurogenic region

, sense organ | precursor

, embryonic peripheral nervous system | restricted

, gastric caecum

, myoblast &&of larval muscle system

, embryonic brain

, anterior midgut proper primordium

, embryonic/larval trachea

, Malpighian tubule

, ventral nerve cord | restricted

, neuroblast

, C1 chordotonal organ precursor cell

, embryonic/larval pharynx

" " embryonic stage | stage 13-15 , embryonic stage | stage 10-12 , embryonic stage | stage >=15 , embryonic stage | stage 10-13 , embryonic stage | stage 11-13 , embryonic stage | stage 6 , embryonic stage , embryonic stage | stage 10 , embryonic stage | stage 9-11 , pupal stage | >20 hr " " embryonic/larval midgut

, anterior midgut proper primordium

, embryonic/larval pharynx

, myoblast &&of larval muscle system

, sense organ | precursor

, embryonic/larval hindgut

, procephalic neurogenic region

, ventral nerve cord | restricted

, ganglion mother cell

, posterior midgut proper primordium

, neuroblast

, dorsal mesothoracic disc | restricted

, Malpighian tubule

, gastric caecum

, embryonic/larval trachea

" "lethal,recessive,viable,fertile,some die during immature adult stage,lethal - all die before end of embryonic stage,some die during embryonic stage,visible,partially lethal - majority die,wild-type,neuroanatomy defective,somatic clone,cell polarity defective" "wing,presumptive embryonic/larval peripheral nervous system,chordotonal organ,imaginal disc,scutellar bristle,tormogen cell,trichogen cell,embryonic/larval somatic muscle,pericardial cell,mesothoracic lateral longitudinal muscle,abdominal dorsal oblique muscle,abdominal dorsal transverse muscle,abdominal lateral transverse muscle,abdominal adult muscle precursor cell,abdominal 1 lateral adult muscle precursor cell,abdominal 2 lateral adult muscle precursor cell,abdominal 3 lateral adult muscle precursor cell,abdominal 4 lateral adult muscle precursor cell,abdominal 5 lateral adult muscle precursor cell,abdominal 6 lateral adult muscle precursor cell,abdominal 7 lateral adult muscle precursor cell,mesothoracic ventral oblique muscle,abdominal ventral oblique muscle,somatic muscle,hypodermal muscle of larval abdominal 9,abdominal lateral pentascolopidial chordotonal organ,metathoracic ventral oblique muscle,abdominal ventral longitudinal muscle,metathoracic ventral longitudinal muscle,mesothoracic ventral longitudinal muscle,mesothoracic segment border muscle,metathoracic segment border muscle,abdominal segment border muscle,abdominal lateral longitudinal muscle,Malpighian tubule tip cell,abdominal 1 lch5 neuron,abdominal 2 lch5 neuron,abdominal 3 lch5 neuron,abdominal 4 lch5 neuron,abdominal 5 lch5 neuron,abdominal 6 lch5 neuron,abdominal 7 lch5 neuron,abdominal dorsal acute muscle,dorsal oblique muscle,prothoracic dorsal oblique muscle,mesothoracic dorsal oblique muscle,metathoracic dorsal oblique muscle,mesothoracic dorsal acute muscle 1,metathoracic dorsal acute muscle,abdominal anterior ventral multidendritic neuron vdaa,abdominal vesA neuron,abdominal v'esA neuron,abdominal vesB neuron,abdominal v'esB neuron,abdominal vesC neuron,ventral multidendritic neuron vdaA,ventral multidendritic neuron vdaB,ventral multidendritic neuron vdaC,ventral multidendritic neuron vdaD,abdominal ventral bipolar neuron vbp,adult muscle precursor cell,ganglion mother cell GMC1-1a,ganglion mother cell GMC4-2a,pCC neuron,RP2sib neuron,abdominal ventral multidendritic neuron,neuroblast,RP2 motor neuron,aCC neuron,U neuron,EL neuron,presumptive embryonic/larval central nervous system,presumptive embryonic/larval digestive system,external sensory organ precursor cell I,ventral nerve cord primordium" FBgn0001981 esg escargot http://flybase.org/reports/FBgn0001981 "FBgn0000445, FBgn0011711, FBgn0015967" protein_coding_gene "DNA binding ; GO:0003677 | inferred from direct assay transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ; GO:0001078 | inferred from direct assay" "epithelial cell migration, open tracheal system ; GO:0007427 | inferred from mutant phenotype olfactory behavior ; GO:0042048 | inferred from mutant phenotype fusion cell fate specification ; GO:0035156 | traceable author statement negative regulation of DNA endoreduplication ; GO:0032876 | inferred from mutant phenotype positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 | inferred from mutant phenotype cell fate specification ; GO:0001708 | inferred from mutant phenotype cell fate determination ; GO:0001709 | inferred from mutant phenotype positive regulation of transcription, DNA-templated ; GO:0045893 | inferred from mutant phenotype germ-line stem cell population maintenance ; GO:0030718 | inferred from mutant phenotype peripheral nervous system development ; GO:0007422 | traceable author statement regulation of compound eye pigmentation ; GO:0048076 | inferred from mutant phenotype open tracheal system development ; GO:0007424 | non-traceable author statement open tracheal system development ; GO:0007424 | traceable author statement asymmetric neuroblast division ; GO:0055059 | inferred from genetic interaction with wor, sna gravitaxis ; GO:0042332 | inferred from mutant phenotype negative regulation of transcription, DNA-templated ; GO:0045892 | inferred from direct assay central nervous system development ; GO:0007417 | inferred from mutant phenotype inferred from genetic interaction with UniProtKB:P08044 maintenance of imaginal histoblast diploidy ; GO:0007489 | inferred from mutant phenotype wing disc development ; GO:0035220 | inferred from mutant phenotype genital disc development ; GO:0035215 | inferred from mutant phenotype response to nicotine ; GO:0035094 | inferred from mutant phenotype negative regulation of transcription from RNA polymerase II promoter ; GO:0000122 | inferred from direct assay branch fusion, open tracheal system ; GO:0035147 | traceable author statement branch fusion, open tracheal system ; GO:0035147 | inferred from mutant phenotype open tracheal system development ; GO:0007424 | inferred from mutant phenotype" nucleus ; GO:0005634 | inferred from sequence or structural similarity nucleus ; GO:0005634 | inferred by curator from GO:0003677 nucleus ; GO:0005634 | inferred from direct assay "esg, CG3758, BG:DS07851.7, l(2)35Ce, l(2)br43, wiz, l(2)esg, l35Ce, dgl, 4B7, br43, shof, l(2)4B7, l(2)07082, flg, Esg" IPR013087:Zinc finger C2H2-type CG3758 27-Aug-18 DroID_v2018_08 "Drer\prdm1a, Drer\snai1b, Drer\scrt1a, Drer\scrt1b, Drer\snai3, Drer\scrt2, Drer\znf410, Drer\snai1a, Drer\snai2" "Scer\YPR015C, Scer\AZF1" "Cele\klf-1, Cele\snai-1, Cele\M03D4.4, Cele\ztf-23, Cele\klu-1, Cele\ces-1" "Xtro\wt1, Xtro\snai2, Xtro\snai1, Xtro\znf410" "Mmus\Zfp410, Mmus\Snai1, Mmus\Scrt1, Mmus\Snai2, Mmus\Snai3, Mmus\Scrt2" "Hsap\ZNF683, Hsap\SCRT1, Hsap\SNAI3, Hsap\ZNF410, Hsap\SCRT2, Hsap\SNAI2, Hsap\ZNF710, Hsap\SNAI1" " larval stage | third instar , embryonic stage | stage 14 , embryonic stage | stage 14-16 , embryonic stage | stage 11 , embryonic stage | stage 16 , embryonic stage | stage 12 , embryonic stage && pupal stage , embryonic stage | stage 8-9 , embryonic stage " " central nervous system

, histoblast nest

, ventral midline

, dorsal mesothoracic disc | presumptive

, head

, ventral thoracic disc | presumptive

, dorsal metathoracic disc primordium

, embryonic/larval trachea

, ventral mesothoracic disc

, dorsal metathoracic disc

, histoblast

, dorsal ridge

, imaginal disc

, peripheral nervous system

, dorsal mesothoracic disc

, ventral neurogenic region

, ventral metathoracic disc

, genital disc

, ventral prothoracic disc

, ectoderm

" " embryonic stage | stage 13 , embryonic stage | stage 15 , embryonic stage | stage 5 " " tracheal fusion cell

, dorsal mesothoracic disc | presumptive

, ventral thoracic disc primordium | restricted & proximal

, dorsal mesothoracic disc

, dorsal metathoracic disc | presumptive

, embryonic/larval anterior spiracle

, genital disc | presumptive

, dorsal metathoracic disc

, ventral thoracic disc | presumptive

" "lethal,recessive,neurophysiology defective,female sterile,visible,dominant,partially lethal - majority die,lethal - all die before end of larval stage,some die during larval stage,viable,fertile,lethal - all die before end of embryonic stage,some die during embryonic stage,smell perception defective,gravitaxis defective,lethal - all die before end of pupal stage,some die during pupal stage,wild-type,somatic clone,heat sensitive,lethal - all die during pupal stage" "rhabdomere R7,embryonic/larval hemocyte | third instar larval stage,eye,macrochaeta & scutum-537.4,microchaeta & scutum-537.4,wing,chordotonal organ,lateral,imaginal disc,embryonic/larval tracheal system,ventral thoracic disc,somatic clone,embryonic/larval dorsal branch 1,embryonic/larval dorsal branch 2,embryonic/larval dorsal branch 3,embryonic/larval dorsal branch 4,embryonic/larval dorsal branch 5,embryonic/larval dorsal branch 6,embryonic/larval dorsal branch 7,embryonic/larval dorsal branch 8,embryonic/larval dorsal branch 9,embryonic/larval dorsal branch 10,embryonic/larval dorsal trunk,secondary pigment cell,tertiary pigment cell,histoblast,testis,macrochaeta,chaeta,adult thorax,thecogen cell,external sensory organ,tergite,sternite,lateral transverse muscle,muscle fiber,germinal proliferation center hub,hub cell,ommatidium,interommatidial bristle,scutellar bristle & trichogen cell455.2,scutellar bristle & tormogen cell455.2,tracheal system,leg,leg sensillum,leg & trichome | somatic clone,embryonic/larval salivary gland | embryonic stage,tracheal air sac,heat sensitive,dorsal air sac primordium tip cell,scutellar bristle,pigment cell,supernumerary" FBgn0259685 crb crumbs http://flybase.org/reports/FBgn0259685 protein_coding_gene "calcium ion binding ; GO:0005509 | inferred from electronic annotation with InterPro:IPR001881, InterPro:IPR018097 spectrin binding ; GO:0030507 | traceable author statement protein kinase C binding ; GO:0005080 | inferred from physical interaction with aPKC" "morphogenesis of an epithelium=0002009 | traceable author statement <> establishment or maintenance of polarity of embryonic epithelium=0016332 |...<> zonula adherens assembly=0045186 | traceable author statement <> establishment of epithelial cell apical/basal polarity=0045198 | traceable author statement <> compound eye photoreceptor development=0042051 | traceable author statement <> cell morphogenesis involved in Malpighian tubule morphogenesis=0061336 |...<> salivary gland development=0007431 | traceable author statement <> zonula adherens assembly=0045186 |...<> rhabdomere development=0042052 |...<> amnioserosa maintenance=0046665 |...<> establishment or maintenance of epithelial cell apical/basal polarity=0045197 | traceable author statement <> dorsal closure, amnioserosa morphology change=0046664 |...<> cuticle development=0042335 |... genetic interaction with UniProtKB:Q0KHR3,UniProtKB:Q9VX75,UniProtKB:X2JCB3,UniProtKB:X2JFU8 <> zonula adherens maintenance=0045218 |...<> photoreceptor cell maintenance=0045494 |...<> liquid clearance, open tracheal system=0035002 |... genetic interaction with crb <> adherens junction organization=0034332 |...<> negative regulation of Notch signaling pathway=0045746 |... genetic interaction with N <> rhabdomere morphogenesis=0061541 |...<> negative regulation of proteasomal ubiquitin-dependent protein catabolic process=0032435 |... genetic interaction with Prosβ6 <> nuclear chromosome segregation=0098813 |...<> open tracheal system development=0007424 |...<> establishment or maintenance of cell polarity=0007163 |...<> negative regulation of organ growth=0046621 |...<> oogenesis=0048477 |...<> regulation of imaginal disc growth=0045570 |...<> establishment or maintenance of apical/basal cell polarity=0035088 |...<> membrane organization=0061024 |...<> zonula adherens maintenance=0045218 | <> positive regulation of phosphorylation=0042327 |...<> morphogenesis of a polarized epithelium=0001738 | traceable author statement <> compound eye photoreceptor development=0042051 |...<> establishment or maintenance of polarity of follicular epithelium=0016334 |...<> salivary gland morphogenesis=0007435 |...<> protein localization=0008104 | traceable author statement <> protein stabilization=0050821 |...<> centrosome localization=0051642 |...<> nervous system development=0007399 |...<> compound eye morphogenesis=0001745 |...inferred from genetic interaction with ex inferred from genetic interaction with Mer inferred from genetic interaction with kibra <> membrane organization=0061024 | traceable author statement <> cell-cell junction assembly=0007043 | <> morphogenesis of an epithelium=0002009 | <> maintenance of apical/basal cell polarity=0035090 |...<> Malpighian tubule morphogenesis=0007443 |...<> positive regulation of cell proliferation=0008284 |...<> regulation of intracellular protein transport=0033157 |...<> regulation of hippo signaling=0035330 |... genetic interaction with ex inferred from genetic interaction with Mer inferred from genetic interaction with kibra <> regulation of protein localization=0032880 |...<> rhabdomere development=0042052 | <> dorsal closure=0007391 |...<> establishment or maintenance of cell polarity=0007163 | <> photoreceptor cell maintenance=0045494 | <> tube morphogenesis=0035239 |... mutant phenotype" apical plasma membrane ; GO:0016324 | non-traceable author statement apical plasma membrane ; GO:0016324 | inferred from direct assay septate junction ; GO:0005918 | traceable author statement plasma membrane ; GO:0005886 | inferred from direct assay apical plasma membrane ; GO:0016324 | traceable author statement rhabdomere ; GO:0016028 | inferred from direct assay integral component of membrane ; GO:0016021 | traceable author statement subapical complex ; GO:0035003 | traceable author statement plasma membrane ; GO:0005886 | inferred from sequence or structural similarity apicolateral plasma membrane ; GO:0016327 | inferred from direct assay inferred from physical interaction with sdt apicolateral plasma membrane ; GO:0016327 | inferred from direct assay "Crb, crb, far, Crumbs, Crbs, crumb, CT19912, CRB, l(3)j1B5, l(3)07207, 0509/20, 1384/04, l(3)S058104, CG6383, l(3)S050920, DmCrb, crumbs" "IPR018097:EGF-like calcium-binding, conserved site, IPR000152:EGF-type aspartate/asparagine hydroxylation site, IPR000742:EGF-like domain, IPR001791:Laminin G domain, IPR001881:EGF-like calcium-binding domain, IPR013032:EGF-like, conserved site, IPR013320:Concanavalin A-like lectin/glucanase domain, IPR009030:Growth factor receptor cysteine-rich domain" CG6383 27-Aug-18 DroID_v2018_08 "Drer\dpy19l1l, Drer\zgc:158328, Drer\svep1, Drer\adgrl4, Drer\si:ch73-173h19.3, Drer\scube1, Drer\adgrf6, Drer\col28a1a, Drer\gas6, Drer\crb2a, Drer\notch1b, Drer\dlb, Drer\fbn2b, Drer\efemp1, Drer\notch3, Drer\jag1a, Drer\crb1, Drer\jag1b, Drer\sned1, Drer\ltbp3, Drer\jag2a, Drer\LOC562634, Drer\fbln1, Drer\pros1, Drer\jag2b, Drer\notch1a, Drer\fbn2a, Drer\col28a1a, Drer\megf6b, Drer\notch2, Drer\crb2b, Drer\matn3a, Drer\si:ch211-69e5.1, Drer\LOC100535882, Drer\fbln7, Drer\scube3, Drer\LOC100332841" - "Cele\lin-12, Cele\glp-1, Cele\crb-1, Cele\mup-4, Cele\fbn-1, Cele\mua-3, Cele\slt-1" "Xtro\fbn1, Xtro\hgfac, Xtro\notch1, Xtro\matn4, Xtro\ltbp4, Xtro\svep1, Xtro\f12, Xtro\crb1, Xtro\jag1, Xtro\col14a1, Xtro\nell1, Xtro\crb2" "Mmus\Jag1, Mmus\Ltbp4, Mmus\Habp2, Mmus\Dlk2, Mmus\Hgfac, Mmus\Hmcn2, Mmus\Sned1, Mmus\Scube3, Mmus\Fbln7, Mmus\Fbn1, Mmus\Tdgf1, Mmus\Notch4, Mmus\Svep1, Mmus\Col22a1, Mmus\Crb1, Mmus\Fbn2, Mmus\Cfc1, Mmus\Vwde, Mmus\Egfl7, Mmus\Gas6, Mmus\Notch1, Mmus\Pros1, Mmus\Vwa1, Mmus\Cntnap2, Mmus\Jag2, Mmus\Ltbp1, Mmus\Dll4, Mmus\Notch3, Mmus\Matn3, Mmus\Col28a1, Mmus\Vwce, Mmus\Crb2, Mmus\Scube2, Mmus\Notch2, Mmus\Dll3, Mmus\F12, Mmus\Dlk1" "Hsap\SCUBE3, Hsap\F12, Hsap\SNED1, Hsap\EGFL7, Hsap\FBN1, Hsap\PROS1, Hsap\COL22A1, Hsap\LTBP1, Hsap\DLL3, Hsap\DLK2, Hsap\CRB1, Hsap\CRB2, Hsap\FBN3, Hsap\DLK1, Hsap\FBN2, Hsap\FBLN7, Hsap\VWCE, Hsap\CFC1B, Hsap\SVEP1, Hsap\VWA1, Hsap\CNTNAP2, Hsap\NOTCH1, Hsap\EYS, Hsap\MATN3, Hsap\NOTCH3, Hsap\GAS6, Hsap\NOTCH2, Hsap\TDGF1, Hsap\JAG2, Hsap\CFC1, Hsap\LOC100996717, Hsap\DLL4, Hsap\HGFAC, Hsap\HABP2, Hsap\JAG1, Hsap\NOTCH4, Hsap\SCUBE2, Hsap\NOTCH2NL, Hsap\COL14A1" " embryonic stage -- adult stage , embryonic stage | late , embryonic stage " " adult salivary gland primordium

posterior & dorsal , embryonic/larval hindgut

" " embryonic stage | late , larval stage | third instar , adult stage | male , embryonic stage , embryonic stage | stage 8-11 , pupal stage , embryonic stage | stage 16 , adult stage && oogenesis stage " " adult salivary gland primordium

, embryonic/larval garland cell

, ejaculatory bulb

, ectoderm

, optic lobe

, neuroblast

, photoreceptor cell stalk | apical

, hindgut

, embryonic/larval salivary gland

, external sensory organ

, embryonic/larval foregut

, ejaculatory duct

, embryonic peripheral nervous system

, testicular duct

, peripodial epithelium

, stomodeum

, salivary gland imaginal ring

, posterior embryonic/larval midgut

, embryonic/larval hindgut

, Malpighian tubule

, epithelial cell

, seminal vesicle

, follicle cell

, embryonic/larval trachea

, imaginal disc

, stomatogastric nervous system

, endoderm

, chordotonal organ

, male accessory gland

" FBgn0010389 htl heartless http://flybase.org/reports/FBgn0010389 "FBgn0004599, FBgn0022791" protein_coding_gene "fibroblast growth factor-activated receptor activity ; GO:0005007 | inferred from electronic annotation with InterPro:IPR016248 ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR016248, InterPro:IPR017441 fibroblast growth factor-activated receptor activity ; GO:0005007 | traceable author statement protein tyrosine kinase activity ; GO:0004713 | non-traceable author statement protein tyrosine kinase activity ; GO:0004713 | inferred from sequence or structural similarity with UniProtKB:P11362" "protein phosphorylation ; GO:0006468 | inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR001245, InterPro:IPR008266, InterPro:IPR016248, InterPro:IPR020635 positive regulation of cell proliferation ; GO:0008284 | inferred from electronic annotation with InterPro:IPR016248 mesoderm migration involved in gastrulation ; GO:0007509 | non-traceable author statement regulation of cell shape ; GO:0008360 | inferred from mutant phenotype mesodermal cell fate determination ; GO:0007500 | inferred from expression pattern glial cell migration ; GO:0008347 | inferred from mutant phenotype germ cell migration ; GO:0008354 | inferred from mutant phenotype heart development ; GO:0007507 | traceable author statement ventral cord development ; GO:0007419 | inferred from mutant phenotype lymph gland development ; GO:0048542 | inferred from mutant phenotype fibroblast growth factor receptor signaling pathway ; GO:0008543 | traceable author statement defense response to Gram-negative bacterium ; GO:0050829 | inferred from mutant phenotype larval visceral muscle development ; GO:0007523 | inferred from mutant phenotype heart development ; GO:0007507 | inferred from expression pattern central nervous system development ; GO:0007417 | inferred from mutant phenotype glial cell development ; GO:0021782 | inferred from mutant phenotype cell migration ; GO:0016477 | traceable author statement somatic muscle development ; GO:0007525 | inferred from mutant phenotype positive regulation of innate immune response ; GO:0045089 | inferred from mutant phenotype glial cell differentiation ; GO:0010001 | inferred from mutant phenotype gastrulation ; GO:0007369 | non-traceable author statement visceral muscle development ; GO:0007522 | inferred from mutant phenotype gonad development ; GO:0008406 | traceable author statement central nervous system development ; GO:0007417 | inferred from expression pattern gonadal mesoderm development ; GO:0007506 | inferred from mutant phenotype mesoderm migration involved in gastrulation ; GO:0007509 | traceable author statement cardioblast differentiation ; GO:0010002 | inferred from mutant phenotype germ cell migration ; GO:0008354 | traceable author statement muscle fiber development ; GO:0048747 | inferred from mutant phenotype heart development ; GO:0007507 | non-traceable author statement pole cell migration ; GO:0007280 | traceable author statement heart development ; GO:0007507 | inferred from mutant phenotype mesodermal cell migration ; GO:0008078 | inferred from mutant phenotype mesodermal cell migration ; GO:0008078 | traceable author statement fibroblast growth factor receptor signaling pathway ; GO:0008543 | inferred from sequence or structural similarity with UniProtKB:P11362 mesoderm migration involved in gastrulation ; GO:0007509 | inferred from mutant phenotype mesodermal cell fate commitment ; GO:0001710 | inferred from mutant phenotype inferred from genetic interaction with dpp salivary gland development ; GO:0007431 | traceable author statement pericardial nephrocyte differentiation ; GO:0061320 | inferred from mutant phenotype mesodermal cell fate commitment ; GO:0001710 | inferred from mutant phenotype endodermal cell fate determination ; GO:0007493 | inferred from expression pattern protein phosphorylation ; GO:0006468 | non-traceable author statement" integral component of membrane ; GO:0016021 | inferred from electronic annotation with InterPro:IPR016248 "Htl, heartless, FGFR, CG7223, i79, i100, i150, j372, EMS2, DFR1, CT39172, CT22273, HTL/FGFR1, dtk1, DmHD-38, Dfr-1, DTRK(FR1), FGF-R2, DFGF-R1, FR1, DFR1/DFGF-R2, DFGF-R2, DFR-1, FGFR2, DPR3, Tk1, HD-38, Fr1, Dtk1, Dfr1, htl" "IPR000719:Protein kinase domain, IPR003598:Immunoglobulin subtype 2, IPR003599:Immunoglobulin subtype, IPR007110:Immunoglobulin-like domain, IPR008266:Tyrosine-protein kinase, active site, IPR011009:Protein kinase-like domain, IPR013783:Immunoglobulin-like fold, IPR016248:Fibroblast growth factor receptor family, IPR017441:Protein kinase, ATP binding site, IPR020635:Tyrosine-protein kinase, catalytic domain, IPR001245:Serine-threonine/tyrosine-protein kinase, catalytic domain" CG7223 27-Aug-18 DroID_v2018_08 "Drer\fgfr1b, Drer\si:ch211-167j9.5, Drer\fgfrl1b, Drer\csf1ra, Drer\si:ch73-206d17.1, Drer\flt4, Drer\fgfr3, Drer\fgfrl1a, Drer\styk1, Drer\flt1, Drer\csf1rb, Drer\si:dkey-14o18.6, Drer\tie1, Drer\kita, Drer\pdgfrb, Drer\fgfr1a, Drer\ret, Drer\flt3, Drer\pdgfrl, Drer\pdgfra, Drer\fgfr4, Drer\kdr, Drer\LOC569566, Drer\tek, Drer\kdrl, Drer\fgfr2, Drer\kitb, Drer\tada2b" Scer\SKM1 "Cele\old-1, Cele\igcm-4, Cele\svh-2, Cele\F09A5.2, Cele\egl-15, Cele\kin-9, Cele\R151.1, Cele\C24G6.2, Cele\F09G2.1" "Xtro\flt1, Xtro\csf1r, Xtro\fgfr1, Xtro\styk1, Xtro\tek, Xtro\tie1, Xtro\ret, Xtro\tada2b, Xtro\fgfr3, Xtro\fgfr4, Xtro\pdgfra, Xtro\fgfr2, Xtro\fgfrl1, Xtro\pdgfrl.2, Xtro\kdr, Xtro\pdgfrl, Xtro\flt4" "Mmus\Flt4, Mmus\Fgfr1, Mmus\Flt1, Mmus\Fgfr4, Mmus\Fgfr2, Mmus\Pdgfrl, Mmus\Pdgfra, Mmus\Csf1r, Mmus\Ret, Mmus\Flt3, Mmus\Tie1, Mmus\Styk1, Mmus\Fgfrl1, Mmus\Pdgfrb, Mmus\Tada2b, Mmus\Tek, Mmus\Fgfr3, Mmus\Kdr, Mmus\Kit" "Hsap\TEK, Hsap\TIE1, Hsap\PDGFRL, Hsap\KIT, Hsap\FGFRL1, Hsap\TADA2B, Hsap\PDGFRA, Hsap\STYK1, Hsap\FGFR1, Hsap\FLT3, Hsap\FLT4, Hsap\FGFR2, Hsap\FLT1, Hsap\FGFR4, Hsap\RET, Hsap\CSF1R, Hsap\PDGFRB, Hsap\KDR, Hsap\FGFR3" " embryonic stage | stage 12-16 , embryonic stage | stage 12-13 , embryonic stage | stage 11-12 , embryonic stage | stage 13 , embryonic stage | stage 16 , embryonic stage | stage 9 , embryonic stage | stage 5-9 " " central nervous system

, embryonic/larval hindgut

, myoblast &&of larval muscle system

, abdominal 1--7 lateral transverse muscle 3

, abdominal 1--7 ventral acute muscle 2

, abdominal 1--7 ventral acute muscle 1

, longitudinal connective

, embryonic/larval foregut

, abdominal 1--7 lateral transverse muscle 2

, abdominal 2--7 ventral transverse muscle 1

, somatic mesoderm

, abdominal 1--7 lateral transverse muscle 1

, mesoderm

, head mesoderm

" " larval stage | third instar , embryonic stage | stage 11-12 " " dorsal mesothoracic disc && adepithelial cell | restricted

, mesoderm

" "lethal,recessive,wild-type,cell migration defective,increased cell death,neuroanatomy defective,lethal - all die before end of embryonic stage,some die during embryonic stage,somatic clone,increased cell number,viable,visible" "presumptive embryonic salivary gland,visceral mesoderm,muscle founder cell,myoblast,muscle fiber,glial cell,embryonic/larval dorsal vessel,embryonic visceral muscle,embryonic/larval somatic muscle,interface glial cell,hindgut visceral muscle primordium,hindgut visceral muscle fiber,mesoderm,embryonic/larval muscle system,dorsal,heart primordium,axon & ocellus sensory structureBx-MS1096, Mz1277, twi.PB, htlUAS.cMa,axon & mechanosensory neuron & adult headBx-MS1096, Mz1277, twi.PB, htlUAS.cMa,somatic mesoderm,axon & ocellus sensory structure-537.4, htlDN.UAS.cMb,axon & mechanosensory neuron & adult head-537.4, htlDN.UAS.cMb,cardiogenic mesoderm,lymph gland primordium,embryonic pericardial cell,cardioblast,pericardial cell,embryonic/larval pericardial cell,embryonic/larval cardial cell,ventral nerve cord,ventral furrow,somatic clone,corpus cardiacum primordium,longitudinal visceral muscle primordium,longitudinal visceral muscle fiber,dorsal oblique muscle,ventral longitudinal muscle,ventral oblique muscle,lateral transverse muscle,dorsal transverse muscle,mesothoracic dorsal acute muscle 1,metathoracic dorsal acute muscle 1,abdominal 1 dorsal acute muscle 1,abdominal 2 dorsal acute muscle 1,abdominal 3 dorsal acute muscle 1,abdominal 4 dorsal acute muscle 1,abdominal 5 dorsal acute muscle 1,abdominal 6 dorsal acute muscle 1,abdominal 7 dorsal acute muscle 1,embryonic myoblast,germline cell,gonadal sheath proper primordium,embryonic somatic muscle,axon & ocellus sensory structure-537.4,axon & mechanosensory neuron & adult head-537.4,axon & ocellus sensory structure-537.4, htlAB42,axon & mechanosensory neuron & adult head-537.4, htlAB42,subretinal glial cell,somatic clone | third instar larval stage,ventral nerve cord | embryonic stage,embryonic/larval dorsal vessel | embryonic stage,ventral,axon & ocellus sensory structureBx-MS1096, Mz1277, twi.PB, htlYY262/htlAB42,axon & mechanosensory neuron & adult headBx-MS1096, Mz1277, twi.PB, htlYY262/htlAB42,supernumerary,tarsal levator muscle,wing vein L5,wing vein,ectopic,embryonic cardioblast,trichogen cell" FBgn0266751 lncRNA:CR45224 - http://flybase.org/reports/FBgn0266751 non_protein_coding_gene - - - CR45224 - CR45224 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0016991 ms(2)1336A ms(2)1336A http://flybase.org/reports/FBgn0016991 - gene - - - "ms(3)1336A, ms(2)1336A" - - 27-Aug-18 DroID_v2018_08 - - - - - - spermatid FBgn0044400 Scim27 Sensitized chromosome inheritance modifier 27 http://flybase.org/reports/FBgn0044400 gene - female meiosis chromosome segregation ; GO:0016321 | inferred from mutant phenotype - Scim27 - - 27-Aug-18 DroID_v2018_08 - - - - - - "meiotic cell cycle defective,dominant" FBgn0004907 14-3-3zeta 14-3-3zeta http://flybase.org/reports/FBgn0004907 "FBgn0010635, FBgn0019723, FBgn0023038, FBgn0046306, FBgn0064146" protein_coding_gene protein domain specific binding ; GO:0019904 | inferred from electronic annotation with InterPro:IPR000308 protein homodimerization activity ; GO:0042803 | inferred from direct assay protein binding ; GO:0005515 | inferred from physical interaction with Slob protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with 14-3-3ε protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q45VV3 protein kinase C inhibitor activity ; GO:0008426 | non-traceable author statement protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:A0A0B4K753 "thermosensory behavior ; GO:0040040 | inferred from mutant phenotype chromosome segregation ; GO:0007059 | inferred from mutant phenotype learning or memory ; GO:0007611 | inferred from mutant phenotype protein folding ; GO:0006457 | inferred from direct assay inferred from mutant phenotype oocyte microtubule cytoskeleton polarization ; GO:0008103 | inferred from genetic interaction with 14-3-3ε olfactory learning ; GO:0008355 | non-traceable author statement positive regulation of ERK1 and ERK2 cascade ; GO:0070374 | inferred from genetic interaction with Ras85D mitotic cell cycle, embryonic ; GO:0045448 | inferred from mutant phenotype positive regulation of Ras protein signal transduction ; GO:0046579 | inferred from genetic interaction with Ras85D protein stabilization ; GO:0050821 | inferred from direct assay inferred from mutant phenotype learning or memory ; GO:0007611 | non-traceable author statement germarium-derived oocyte fate determination ; GO:0007294 | inferred from genetic interaction with 14-3-3ε regulation of glucose metabolic process ; GO:0010906 | inferred from mutant phenotype" plasma membrane ; GO:0005886 | inferred from direct assay nuclear membrane ; GO:0031965 | inferred from direct assay germline ring canal ; GO:0045172 | inferred from direct assay microtubule associated complex ; GO:0005875 | inferred from direct assay nucleus ; GO:0005634 | non-traceable author statement nucleus ; GO:0005634 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay "14-3-3zeta, leo, 14-3-3, PAR5, d14-3-3zeta, par-5, Par-5, CG17870, 4-3-3 zeta, D14-3-3zeta, 549, 2G1, 5.11, K, BEST:GH05075, l(2)07103, D14-3-3, l(2)46Ee, l(2)46CFe, 14-3-3ZETA, 14-3-3 zeta, Leo, PAR-5, 14-3-3leo, 14-3-3-zeta, LEO, 14-3-3-Leo" "IPR000308:14-3-3 protein, IPR023409:14-3-3 protein, conserved site, IPR023410:14-3-3 domain" CG17870 27-Aug-18 DroID_v2018_08 "Drer\ywhae1, Drer\ywhaqb, Drer\ywhabl, Drer\ywhabb, Drer\ywhae2, Drer\ywhaqa, Drer\ywhaz, Drer\ywhaba, Drer\ywhag1, Drer\ywhag2, Drer\ywhah" "Scer\BMH1, Scer\BMH2" "Cele\par-5, Cele\ftt-2" "Xtro\ywhah, Xtro\ywhag, Xtro\ywhaq, Xtro\ywhaz, Xtro\ywhab, Xtro\ywhae" "Mmus\Ywhag, Mmus\Ywhaz, Mmus\Cdk5rap2, Mmus\Ywhah, Mmus\Ywhae, Mmus\Sfn, Mmus\Ywhaq, Mmus\Ywhab" "Hsap\YWHAB, Hsap\SFN, Hsap\YWHAG, Hsap\YWHAH, Hsap\YWHAQ, Hsap\YWHAE, Hsap\YWHAZ" " adult stage , embryonic stage , larval stage | third instar , adult stage && oogenesis stage , larval stage " " retina

, adult brain

, ventral nerve cord

, lamina

, adult head

, subesophageal ganglion

, embryonic central nervous system

, optic lobe

, eye disc

, mushroom body

, nurse cell

, thoracico-abdominal ganglion

, oocyte

, antennal lobe

, morphogenetic furrow | posterior to

, larval central nervous system

" " adult stage && oogenesis stage , adult stage , larval stage | third instar , embryonic stage | 16-18hr , embryonic stage | late , embryonic stage | 20 hr , embryonic stage | stage 17 , larval stage " " oocyte

, thoracico-abdominal ganglion

, nurse cell

, ring neuron

, eye disc

, cell body

, synapse

, ellipsoid body

, bouton

, neuromuscular junction

, neuron

, larval muscle system

, morphogenetic furrow | posterior to

, mushroom body

, antennal lobe

" "memory defective,lethal,recessive,lethal - all die before end of embryonic stage,some die during embryonic stage,viable,learning defective,neurophysiology defective,mitotic cell cycle defective,maternal effect,fertile,wild-type" "eye photoreceptor cell,somatic clone,embryonic/first instar larval cuticle,germline clone,denticle belt,syncytial blastoderm embryo,mitotic cell cycle | maternal effect,follicle cell,border follicle cell,photoreceptor cell,embryonic epidermis,lateral,dorsal,embryo,posterior,filzkorper" DRSC05028 I -2.132383757 -1.133882546 0.502046612 0.1426068 -0.137782331 -0.462856079 FBgn0014018 Rel Relish http://flybase.org/reports/FBgn0014018 "FBgn0011469, FBgn0024223" protein_coding_gene "sequence-specific DNA binding ; GO:0043565 | inferred from direct assay transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ; GO:0001077 | inferred from direct assay chromatin binding ; GO:0003682 | inferred from biological aspect of ancestor with PANTHER:PTN001193216 transcription factor activity, sequence-specific DNA binding ; GO:0003700 | traceable author statement protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q8IRY7 RNA polymerase II regulatory region sequence-specific DNA binding ; GO:0000977 | inferred from biological aspect of ancestor with PANTHER:PTN001193216 DNA binding ; GO:0003677 | inferred from direct assay RNA polymerase II transcription factor activity, sequence-specific DNA binding ; GO:0000981 | inferred from direct assay" signal transduction ; GO:0007165 | traceable author statement <> immune response ; GO:0006955 | traceable author statement <> defense response to Gram-negative bacterium ; GO:0050829 |... mutant phenotype <> peptidoglycan recognition protein signaling pathway ; GO:0061057 |... mutant phenotype <> positive regulation of antibacterial peptide biosynthetic process ; GO:0006963 |... expression pattern <> positive regulation of innate immune response ; GO:0045089 |... mutant phenotype <> response to bacterium ; GO:0009617 | traceable author statement <> defense response to Gram-negative bacterium ; GO:0050829 | traceable author statement <> positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria ; GO:0006964 |... mutant phenotype <> innate immune response ; GO:0045087 |... direct assay <> immune response ; GO:0006955 |... mutant phenotype <> NIK/NF-kappaB signaling ; GO:0038061 |... biological aspect of ancestor with PANTHER:PTN001193216 <> I-kappaB kinase/NF-kappaB signaling ; GO:0007249 |... biological aspect of ancestor with PANTHER:PTN001193216 <> positive regulation of defense response to virus by host ; GO:0002230 |... mutant phenotype <> innate immune response ; GO:0045087 | non-traceable author statement <> positive regulation of antibacterial peptide biosynthetic process ; GO:0006963 |... mutant phenotype <> defense response to Gram-negative bacterium ; GO:0050829 |... genetic interaction with PGRP-LE <> cellular response to DNA damage stimulus ; GO:0006974 |... mutant phenotype <> immune response ; GO:0006955 |... expression pattern <> negative regulation of stem cell proliferation ; GO:2000647 |... mutant phenotype <> positive regulation of gene expression ; GO:0010628 |... mutant phenotype <> dendrite morphogenesis ; GO:0048813 |... mutant phenotype <> positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 |... mutant phenotype <> positive regulation of nitric oxide biosynthetic process ; GO:0045429 |... mutant phenotype <> cellular response to amino acid starvation ; GO:0034198 |... mutant phenotype <> defense response to virus ; GO:0051607 |... mutant phenotype <> response to bacterium ; GO:0009617 |... direct assay <> response to cytokine ; GO:0034097 |... biological aspect of ancestor with PANTHER:PTN001193216 <> positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 |... direct assay <> negative regulation of transcription from RNA polymerase II promoter ; GO:0000122 |... biological aspect of ancestor with PANTHER:PTN001193216 <> positive regulation of antibacterial peptide biosynthetic process ; GO:0006963 | non-traceable author statement <> regulation of innate immune response ; GO:0045088 |... mutant phenotype inferred from genetic interaction with brm inferred from genetic interaction with mor <> positive regulation of antifungal peptide biosynthetic process ; GO:0006967 |... mutant phenotype <> positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 | traceable author statement <> Toll signaling pathway ; GO:0008063 | traceable author statement <> positive regulation of antibacterial peptide biosynthetic process ; GO:0006963 | traceable author statement <> peripheral nervous system neuron development ; GO:0048935 |... mutant phenotype nucleus ; GO:0005634 | inferred from direct assay nuclear euchromatin ; GO:0005719 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay cytosol ; GO:0005829 | inferred from biological aspect of ancestor with PANTHER:PTN001193216 I-kappaB/NF-kappaB complex ; GO:0033256 | inferred from biological aspect of ancestor with PANTHER:PTN001193216 "rel, CG11992, REL, ird4, ird, l(3)neo36, Rel, Relish, Rel/NF-kappaB, NF-kappaB, relish, RELI, NFkappaB, Rel-p110, RelA, Rel49" "IPR000451:NF-kappa-B/Dorsal, IPR002110:Ankyrin repeat, IPR002909:IPT domain, IPR008967:p53-like transcription factor, DNA-binding, IPR011539:Rel homology domain (RHD), DNA-binding domain, IPR013783:Immunoglobulin-like fold, IPR014756:Immunoglobulin E-set, IPR020683:Ankyrin repeat-containing domain, IPR033926:NFkappaB IPT domain, IPR032397:Rel homology dimerisation domain" CG11992 27-Aug-18 DroID_v2018_08 "Drer\rel, Drer\relb, Drer\rela, Drer\nfkb1, Drer\nfkb2" - Cele\shn-1 "Xtro\rel, Xtro\nfkb1, Xtro\nfkb2, Xtro\rela" "Mmus\Nfkb2, Mmus\Rel, Mmus\Nfkb1, Mmus\Relb, Mmus\Rela" "Hsap\RELB, Hsap\RELA, Hsap\REL, Hsap\NFKB1, Hsap\NFKB2" " embryonic stage | early , adult stage | female , adult stage && oogenesis stage " nurse cell

"immune response defective,viable,recessive,neuroanatomy defective,visible,fertile,lethal,increased cell death,cold sensitive,dominant,short lived,increased cell number,lethal - all die before end of pupal stage,some die during pupal stage" "dorsal multidendritic neuron ddaC,abdominal anterior ventral multidendritic neuron vdaa,macrochaeta,mesothoracic tergum,ectopic,adult brain,lamina,cold sensitive,dorsocentral bristle,intestinal stem cell,adult posterior midgut epithelium" DRSC16819 E 0.496334294 1.222535901 -0.400910449 2.25077341 0.302072844 -0.43303548 FBgn0262871 lute lute http://flybase.org/reports/FBgn0262871 protein_coding_gene ubiquitin protein ligase binding ; GO:0031625 | inferred from biological aspect of ancestor with PANTHER:PTN000698504 neurogenesis ; GO:0022008 | inferred from mutant phenotype regulation of proteolysis ; GO:0030162 | inferred from biological aspect of ancestor with PANTHER:PTN000698504 proteasome-mediated ubiquitin-dependent protein catabolic process ; GO:0043161 | inferred from biological aspect of ancestor with PANTHER:PTN000698504 neurogenesis ; GO:0022008 | inferred from biological aspect of ancestor with PANTHER:PTN001229949 protein ubiquitination involved in ubiquitin-dependent protein catabolic process ; GO:0042787 | inferred from biological aspect of ancestor with PANTHER:PTN000698504 cytosol ; GO:0005829 | inferred from biological aspect of ancestor with PANTHER:PTN001229949 SCF ubiquitin ligase complex ; GO:0019005 | inferred from biological aspect of ancestor with PANTHER:PTN000698504 "CG5319, CG43226, anon-WO0118547.289, lute, CG14333" "IPR000210:BTB/POZ domain, IPR011705:BTB/Kelch-associated, IPR012983:PHR, IPR011333:SKP1/BTB/POZ domain" CG43226 27-Aug-18 DroID_v2018_08 "Drer\btbd3b, Drer\btbd2, Drer\btbd3a, Drer\btbd6a, Drer\btbd17b, Drer\btbd6b" Scer\YIL001W Cele\tag-30 "Xtro\btbd2, Xtro\btbd1, Xtro\btbd6, Xtro\btbd3" "Mmus\Btbd2, Mmus\Btbd17, Mmus\Btbd1, Mmus\Btbd6, Mmus\Btbd3" "Hsap\BTBD6, Hsap\BTBD17, Hsap\BTBD1, Hsap\BTBD2, Hsap\BTBD3" DRSC25911 K 0.730624677 -0.310276427 -0.779626706 -0.139702429 2.154221261 -0.130102616 FBgn0017456 Ubc84D Ubiquitin conjugating enzyme 84D http://flybase.org/reports/FBgn0017456 - protein_coding_gene ubiquitin-protein transferase activity ; GO:0004842 | inferred from sequence or structural similarity with SGD:S000002466 ubiquitin-protein transferase activity ; GO:0004842 | inferred from sequence or structural similarity protein polyubiquitination ; GO:0000209 | inferred from sequence or structural similarity with SGD:S000002466 cellular_component ; GO:0005575 | no biological data available "ubc, CG12799, Ubc84D, UbcD84" "IPR000608:Ubiquitin-conjugating enzyme E2, IPR016135:Ubiquitin-conjugating enzyme/RWD-like, IPR023313:Ubiquitin-conjugating enzyme, active site" CG12799 27-Aug-18 DroID_v2018_08 "Drer\ube2l3a, Drer\ube2l3b" Scer\UBC4 "Cele\ubc-24, Cele\ubc-18" Xtro\ube2l3 "Mmus\Ube2l6, Mmus\Gm10705, Mmus\Ube2l3" "Hsap\UBE2L3, Hsap\UBE2L6" viable DRSC25384 IK 1.708094409 0.802952012 1.24885621 0.383343257 6.682892325 6.840966 FBgn0003714 tko technical knockout http://flybase.org/reports/FBgn0003714 - protein_coding_gene structural constituent of ribosome ; GO:0003735 | traceable author statement structural constituent of ribosome ; GO:0003735 | inferred from sequence or structural similarity with UniProtKB:O15235 structural constituent of ribosome ; GO:0003735 | inferred from sequence or structural similarity with UniProtKB:Q29RU1 courtship behavior ; GO:0007619 | traceable author statement response to hypoxia ; GO:0001666 | inferred from direct assay mechanosensory behavior ; GO:0007638 | inferred from mutant phenotype mitochondrial translation ; GO:0032543 | traceable author statement sensory perception of sound ; GO:0007605 | inferred from mutant phenotype response to mechanical stimulus ; GO:0009612 | inferred from mutant phenotype mitochondrial translation ; GO:0032543 | inferred from sequence or structural similarity with UniProtKB:Q29RU1 translation ; GO:0006412 | inferred from sequence or structural similarity with UniProtKB:O15235 male courtship behavior ; GO:0008049 | inferred from mutant phenotype mitochondrial small ribosomal subunit ; GO:0005763 | inferred from sequence or structural similarity with UniProtKB:O15235 mitochondrial small ribosomal subunit ; GO:0005763 | traceable author statement mitochondrial small ribosomal subunit ; GO:0005763 | inferred from sequence or structural similarity with UniProtKB:Q29RU1 "MRPS12, EG:BACH59J11.1, S12, MRP-S12, CG7925, rps12, mt-rps12, l(1)tko, mRpS12, l(1)3Ab, tko, Tko" "IPR005679:Ribosomal protein S12, bacterial-type, IPR006032:Ribosomal protein S12/S23, IPR012340:Nucleic acid-binding, OB-fold" CG7925 27-Aug-18 DroID_v2018_08 Drer\si:dkey-17e16.10 Scer\MRPS12 Cele\mrps-12 Xtro\mrps12 Mmus\Mrps12 Hsap\MRPS12 "lethal,some die during third instar larval stage,some die during second instar larval stage,wild-type,viable,female sterile,recessive,developmental rate defective,bang sensitive,neuroanatomy defective,somatic clone,lethal - all die before end of larval stage,some die during larval stage,cell lethal,germline clone,visible,courtship behavior defective,male,mating defective,auditory perception defective,female,cold sensitive,chemical sensitive,neurophysiology defective,male limited,behavior defective" "egg,adult antennal lobe projection neuron DL1 adPN,somatic clone,gamma Kenyon cell,macrochaeta" DRSC27125 K 0.400620664 -0.898350641 -1.15436026 0.125075653 1.423632656 2.14779984 FBgn0030350 SelG Selenoprotein G http://flybase.org/reports/FBgn0030350 protein_coding_gene molecular_function ; GO:0003674 | no biological data available calcium ion transport ; GO:0006816 | inferred from biological aspect of ancestor with PANTHER:PTN000423974 blastoderm segmentation ; GO:0007350 | inferred from direct assay embryo development ; GO:0009790 | inferred from direct assay determination of adult lifespan ; GO:0008340 | inferred from direct assay regulation of gastrulation ; GO:0010470 | inferred from direct assay cell redox homeostasis ; GO:0045454 | traceable author statement embryonic development via the syncytial blastoderm ; GO:0001700 | inferred from direct assay immune system process ; GO:0002376 | inferred from biological aspect of ancestor with PANTHER:PTN001047971 endoplasmic reticulum calcium ion homeostasis ; GO:0032469 | inferred from mutant phenotype intracellular membrane-bounded organelle ; GO:0043231 | inferred from direct assay Golgi apparatus ; GO:0005794 | inferred from direct assay endoplasmic reticulum membrane ; GO:0005789 | inferred from biological aspect of ancestor with PANTHER:PTN000423974 "G-rich, CG1844, dselG, BcDNA:GH03581, SelG, dselK, dSelK, SelK" IPR024491:Selenoprotein SelK/SelG CG1844 27-Aug-18 DroID_v2018_08 Drer\selk - Cele\Y41E3.8 Xtro\selk Mmus\Selenok Hsap\SELENOK "developmental rate defective,lethal - all die before end of embryonic stage,some die during embryonic stage,viable" DRSC19808 I 3.865047298 1.246750564 0.351680904 0.676829115 -0.680738177 -0.465606497 FBgn0037492 CG10050 - http://flybase.org/reports/FBgn0037492 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG10050 IPR005636:DTW CG10050 27-Aug-18 DroID_v2018_08 Drer\dtwd2 - - Xtro\dtwd2 Mmus\Dtwd2 Hsap\DTWD2 viable DRSC12501 I 1.825219104 0.247793754 0.142794582 0.419107609 -0.229254431 -0.125008409 FBgn0032518 RpL24 Ribosomal protein L24 http://flybase.org/reports/FBgn0032518 protein_coding_gene structural constituent of ribosome ; GO:0003735 | traceable author statement structural constituent of ribosome ; GO:0003735 | inferred from direct assay cytoplasmic translation ; GO:0002181 | inferred by curator from GO:0022626 cytoplasmic translation ; GO:0002181 | traceable author statement centrosome duplication ; GO:0051298 | inferred from mutant phenotype ribosomal large subunit assembly ; GO:0000027 | inferred from biological aspect of ancestor with PANTHER:PTN000846433 assembly of large subunit precursor of preribosome ; GO:1902626 | inferred from biological aspect of ancestor with PANTHER:PTN000846433 ribosome ; GO:0005840 | inferred from direct assay cytosolic ribosome ; GO:0022626 | inferred from direct assay cytosolic large ribosomal subunit ; GO:0022625 | traceable author statement "CG9282, anon-EST:Posey37, anon-EST:Posey242, RpL24, Rp L24, L24, RL24_DROME, Rpl24" "IPR000988:Ribosomal protein L24e-related, IPR011017:TRASH domain" CG9282 27-Aug-18 DroID_v2018_08 Drer\rpl24 "Scer\RPL24A, Scer\RPL24B" Cele\rpl-24.1 Xtro\rpl24 Mmus\Rpl24 Hsap\RPL24 DRSC28724 IEK -2.36034726 -1.632061247 0.017070946 -3.471017496 1.63370372 2.705123609 FBgn0022986 qkr58E-1 quaking related 58E-1 http://flybase.org/reports/FBgn0022986 - protein_coding_gene RNA binding ; GO:0003723 | inferred from electronic annotation with InterPro:IPR004088 "neurogenesis ; GO:0022008 | inferred from mutant phenotype mRNA splicing, via spliceosome ; GO:0000398 | inferred by curator from GO:0071011,GO:0071013" nucleus ; GO:0005634 | inferred from direct assay precatalytic spliceosome ; GO:0071011 | inferred from direct assay catalytic step 2 spliceosome ; GO:0071013 | inferred from direct assay "qkr-58-E, CG3613, qrk58E-1, qkr58E-1, QKR58E-1, Qkr58E-1" "IPR004087:K Homology domain, IPR004088:K Homology domain, type 1" CG3613 27-Aug-18 DroID_v2018_08 "Drer\khdrbs1b, Drer\qkia, Drer\qki2, Drer\khdrbs1a, Drer\qkib, Drer\khdrbs2, Drer\khdrbs3" Scer\MSL5 "Cele\asd-2, Cele\Y57G11C.36, Cele\gld-1, Cele\K07H8.9" "Xtro\khdrbs3, Xtro\qki, Xtro\khdrbs1, Xtro\khdrbs2" "Mmus\Khdrbs2, Mmus\Qk, Mmus\Khdrbs3, Mmus\Khdrbs1" "Hsap\KHDRBS3, Hsap\QKI, Hsap\KHDRBS2, Hsap\KHDRBS1" "lethal,neuroanatomy defective,visible,partially lethal - majority die,some die during pupal stage" "embryonic/larval neuroblast,ganglion mother cell,trichogen cell,mesothoracic tergum" DRSC04709 I -1.4465963 2.040712099 0.261037455 -0.355408436 -0.070910723 -0.59231784 FBgn0002573 sens senseless http://flybase.org/reports/FBgn0002573 "FBgn0011709, FBgn0027151, FBgn0036355, FBgn0052120" protein_coding_gene "transcription factor activity, sequence-specific DNA binding ; GO:0003700 | non-traceable author statement bHLH transcription factor binding ; GO:0043425 | inferred from direct assay transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ; GO:0003705 | inferred from direct assay transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ; GO:0001077 | contributes_to inferred from direct assay sequence-specific DNA binding ; GO:0043565 | inferred from direct assay" negative regulation of apoptotic process ; GO:0043066 | inferred from mutant phenotype sensory organ development ; GO:0007423 | inferred from mutant phenotype inferred from genetic interaction with sc inferred from genetic interaction with da neuron development ; GO:0048666 | inferred from mutant phenotype photoreceptor cell morphogenesis ; GO:0008594 | inferred from mutant phenotype inferred from genetic interaction with ro peripheral nervous system development ; GO:0007422 | traceable author statement photoreceptor cell differentiation ; GO:0046530 | inferred from mutant phenotype negative regulation of transcription from RNA polymerase II promoter ; GO:0000122 | inferred from direct assay sensory organ development ; GO:0007423 | inferred from mutant phenotype peripheral nervous system development ; GO:0007422 | non-traceable author statement R8 cell differentiation ; GO:0045465 | non-traceable author statement sensory organ precursor cell fate determination ; GO:0016360 | inferred from mutant phenotype chaeta morphogenesis ; GO:0008407 | inferred from mutant phenotype positive regulation of rhodopsin gene expression ; GO:0045872 | inferred from mutant phenotype dendrite morphogenesis ; GO:0048813 | inferred from mutant phenotype sensory organ development ; GO:0007423 | traceable author statement compound eye photoreceptor development ; GO:0042051 | inferred from mutant phenotype peripheral nervous system development ; GO:0007422 | inferred from mutant phenotype axon guidance ; GO:0007411 | inferred from mutant phenotype nucleus ; GO:0005634 | inferred from direct assay polytene chromosome ; GO:0005700 | inferred from direct assay "Sens, sens, Sen, sense, Ly, CG10714, Ly-1, 1228/04, l(3)70Ad, CG32120, sen, senseless, SENS, Ss, Gfi1, Senseless" IPR013087:Zinc finger C2H2-type CG32120 27-Aug-18 DroID_v2018_08 "Drer\prdm13, Drer\gfi1b, Drer\gfi1aa, Drer\gfi1ab" - "Cele\ztf-30, Cele\pag-3, Cele\B0310.2" "Xtro\gfi1b, Xtro\gfi1" "Mmus\Prdm13, Mmus\Gfi1, Mmus\Gfi1b" "Hsap\TIGD1, Hsap\GFI1, Hsap\PRDM13, Hsap\GFI1B" " embryonic stage | stage 11-12 , embryonic stage | stage >=11 , embryonic stage | stage 11-13 , embryonic stage | stage 10 , embryonic stage | stage 10-12 " " external sensory organ precursor cell I

, adult salivary gland primordium

, salivary gland

, external sensory organ precursor cell IIa

, external sensory organ precursor cell IIb

, lateral ectoderm | restricted

, sensory mother cell

, embryonic peripheral nervous system | restricted

" " embryonic stage | stage 11-14 , embryonic stage | stage 10-14 , larval stage | third instar , embryonic stage | stage >=11 " " salivary gland

, embryonic peripheral nervous system | restricted

, Johnston's organ

, adult salivary gland primordium

, metathoracic femoral chordotonal organ

, sensory mother cell

, mesothoracic femoral chordotonal organ

, photoreceptor cell R8

, prothoracic femoral chordotonal organ

, eye-antennal disc | restricted

, dorsal mesothoracic disc | restricted

" "visible,wild-type,lethal,recessive,cell autonomous,somatic clone,increased cell death,neuroanatomy defective,dominant,lethal - all die before end of pupal stage,some die during pupal stage" "scutellar bristle,ectopic,chordotonal organ,external sensory organ,multidendritic neuron,photoreceptor cell R8,somatic clone,cell non-autonomous,ommatidium,photoreceptor cell R7,chaeta,cell autonomous,tormogen cell,microchaeta,photoreceptor cell R2,photoreceptor cell R5,embryonic/larval salivary gland,dorsal row,ventral row,external sensory organ precursor cell IIa,external sensory organ precursor cell IIb,supernumerary,eo neuron,thecogen cell,trichogen cell,mechanosensory chaeta,postorbital bristle,trichome of the posterior wing margin,embryonic/larval oenocyte precursor,medulla,dorsal multidendritic neuron ddaE & dendrite,abdominal dorsal multidendritic neuron ddaE & dendrite,presumptive embryonic/larval peripheral nervous system,embryonic peripheral nervous system & neuronS122804),PNS glial cell,wing margin,wing,anterior wing margin,posterior wing margin,eye,macrochaeta,sensillum campaniformium of dorsal radius,wing sensillum,sternopleural bristle,leg sensillum,leg,distal,scutum,wing & chaetadpp.blk1,leg & chaetadpp.blk1,scutum & chaetadpp.blk1,mesothoracic bristle,microchaeta & scutellum | ectopicC5,mechanosensory sensory organ,metathoracic bristle,prothoracic tarsal bristle,interommatidial bristle,secondary pigment cell,tertiary pigment cell,axon & photoreceptor cell R7 | somatic clonetub.PU" DRSC09263 K -2.589957165 -1.789978122 FBgn0263773 fok fledgling of Klp38B http://flybase.org/reports/FBgn0263773 protein_coding_gene molecular_function ; GO:0003674 | no biological data available - cellular_component ; GO:0005575 | no biological data available "fok, CG43690, 38B.11, CG10746, Fok, l(2)k07614, noncoding_3938, CG42849" - CG43690 27-Aug-18 DroID_v2018_08 - - - - - - " embryonic stage&&adult stage , embryonic stage | >=4 hr , adult stage " DRSC23907 IK -1.656657316 0.333239024 -0.558448272 0.41287203 0.968085545 2.277447487 FBgn0027111 miple1 midkine and pleiotrophin 1 http://flybase.org/reports/FBgn0027111 FBgn0027731 protein_coding_gene growth factor activity ; GO:0008083 | inferred from electronic annotation with InterPro:IPR020090 heparin binding ; GO:0008201 | inferred from sequence or structural similarity with HGNC:6972 heparin binding ; GO:0008201 | inferred from direct assay mesoderm morphogenesis ; GO:0048332 | inferred from mutant phenotype determination of adult lifespan ; GO:0008340 | inferred from mutant phenotype extracellular region ; GO:0005576 | inferred from direct assay "anon-EST:Posey203, CG1221, miple1, miple, Miple" "IPR020090:Pleiotrophin/Midkine, C-terminal domain" CG1221 27-Aug-18 DroID_v2018_08 - - - - - - "viable,fertile,partially lethal - majority die,some die during pupal stage" DRSC08722 E 0.335569321 1.166520862 1.718786772 -0.049063239 -0.556742077 -0.26566344 FBgn0261930 vnd ventral nervous system defective http://flybase.org/reports/FBgn0261930 protein_coding_gene "sequence-specific DNA binding ; GO:0043565 | inferred from electronic annotation with InterPro:IPR017970 transcription factor binding ; GO:0008134 | inferred from physical interaction with D RNA polymerase II transcription factor activity, sequence-specific DNA binding ; GO:0000981 | inferred from direct assay" brain development ; GO:0007420 | inferred from mutant phenotype regulation of transcription from RNA polymerase II promoter ; GO:0006357 | inferred from mutant phenotype pattern specification process ; GO:0007389 | non-traceable author statement ventral cord development ; GO:0007419 | non-traceable author statement dorsal/ventral pattern formation ; GO:0009953 | traceable author statement glial cell development ; GO:0021782 | inferred from mutant phenotype ectoderm development ; GO:0007398 | traceable author statement neuroblast fate determination ; GO:0007400 | traceable author statement positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 | inferred from direct assay neuroblast development ; GO:0014019 | inferred from mutant phenotype neuroblast fate determination ; GO:0007400 | inferred from mutant phenotype ventral cord development ; GO:0007419 | traceable author statement brain development ; GO:0007420 | traceable author statement central nervous system development ; GO:0007417 | non-traceable author statement negative regulation of transcription from RNA polymerase II promoter ; GO:0000122 | inferred from mutant phenotype negative regulation of gene expression ; GO:0010629 | inferred from mutant phenotype nucleus ; GO:0005634 | inferred from direct assay "vnd, vnd/NK-2, EG:118B3.1, CG6172, NK-2, VND, Vnd, dNK-2, l(1)1Bf, NK2, EC6, nk-2, lab, l(1)VE769, l(1)VA208, l(1)RC24, l(1)GA122, l(1)GA100, l(1)EC6, l(1)EA142, Dm-NK2, Nkx2, HDC16822, Dm vnd" "IPR020479:Homeobox domain, metazoa, IPR017970:Homeobox, conserved site, IPR001356:Homeobox domain, IPR009057:Homeobox domain-like" CG6172 27-Aug-18 DroID_v2018_08 "Drer\nkx2.2a, Drer\nkx2.3, Drer\meox2a, Drer\nkx2.5, Drer\nkx2.1, Drer\meox2b, Drer\nkx2.4a, Drer\nkx2.2b, Drer\nkx2.9, Drer\nkx2.4b, Drer\nkx3.2, Drer\nkx3-1, Drer\nkx2.7, Drer\meox1, Drer\nkx3.3" - "Cele\ceh-27, Cele\ceh-22" "Xtro\nkx2-1, Xtro\nkx3-1, Xtro\nkx2-3, Xtro\nkx3-2, Xtro\nkx2-2, Xtro\nkx2-6, Xtro\nkx3-3, Xtro\nkx2-5, Xtro\nkx2-8" "Mmus\Nkx2-3, Mmus\Nkx3-2, Mmus\Nkx2-4, Mmus\Nkx2-2, Mmus\Nkx2-1, Mmus\Nkx2-5, Mmus\Nkx3-1, Mmus\Nkx2-9, Mmus\Nkx2-6" "Hsap\NKX2-1, Hsap\NKX2-8, Hsap\NKX3-2, Hsap\NKX3-1, Hsap\NKX2-2, Hsap\NKX2-5, Hsap\NKX2-6, Hsap\NKX2-4, Hsap\NKX2-3" " embryonic stage | stage 11 , embryonic stage | stage 8-11 , embryonic stage | stage >=10 , embryonic stage | stage >=13 , embryonic stage | stage 7-8 , embryonic stage | stage 7,8 " " neuroblast NB1-2

, neuroblast NB2-1

, ventral neurogenic region | restricted

, neuroblast NB4-1

, central nervous system | restricted

, posterior embryonic/larval midgut

, ventral neurogenic region

, neuroblast | subset

, neuroblast NB2-2

, neuroblast NB1-1

, anterior embryonic/larval midgut

, neuroblast NB6-2

, neuroblast NB5-2

, neuroblast NB3-1

, neuroblast NB6-1

, ventral midline

, neuroblast MP2

, neuroblast NB5-1

, neuroblast NB7-2

, neuroblast NB7-1

" " embryonic stage | stage 11 , embryonic stage | stage 8-9 , embryonic stage | stage 9-11 , embryonic stage | stage 8 , embryonic stage | cellular blastoderm " " pCC neuron

, U neuron

, embryonic neuron | subset

, neuroblast | subset

, procephalic neuroblast | subset & ventral

, protocerebral neuroblast | subset

, tritocerebral neuroblast | subset

, ventral midline

, ventral neurogenic region && embryonic antennal segment | ventral & restricted

, deuterocerebral neuroblast | subset

, ventral neurogenic region | restricted

, ventral neurogenic region && embryonic intercalary segment | ventral & restricted

, ventral neurogenic region && embryonic ocular segment | ventral & restricted

" DRSC18849 I -0.241859869 2.117121463 0.355150963 0.282667908 0.720278343 0.92449675 FBgn0085382 CG34353 - http://flybase.org/reports/FBgn0085382 protein_coding_gene - gravitaxis ; GO:0042332 | inferred from mutant phenotype - "CG34353, CG12274, CG12427, CG12873, CG12874, CG12875, CG5566, CG5572" "IPR013098:Immunoglobulin I-set, IPR003961:Fibronectin type III, IPR007110:Immunoglobulin-like domain, IPR013783:Immunoglobulin-like fold, IPR003598:Immunoglobulin subtype 2, IPR003599:Immunoglobulin subtype" CG34353 27-Aug-18 DroID_v2018_08 "Drer\esama, Drer\negr1, Drer\si:dkey-11p23.7, Drer\zgc:153911, Drer\zgc:110372, Drer\f11r.1, Drer\opcml, Drer\ntm, Drer\jam2a, Drer\vsig8a, Drer\gpa33, Drer\mxra8a, Drer\si:dkey-65b12.12, Drer\jam3b, Drer\zgc:153073, Drer\lsamp, Drer\mxra8b, Drer\cxcr3.1, Drer\cxadr, Drer\vsig8b, Drer\si:dkey-250k15.10, Drer\igsf11, Drer\jam2b, Drer\f11r.2, Drer\esamb, Drer\si:zfos-1011f11.1, Drer\jam3a" - "Cele\wrk-1, Cele\rig-5" "Xtro\negr1, Xtro\lsamp, Xtro\ntm" "Mmus\Fgfrl1, Mmus\Gm1123, Mmus\Esam, Mmus\Cxadr, Mmus\Lsamp, Mmus\Gpa33, Mmus\Jam2, Mmus\Clmp, Mmus\F11r, Mmus\Jam3, Mmus\Opcml, Mmus\Vsig1, Mmus\Mxra8, Mmus\Vsig2, Mmus\Negr1, Mmus\Vsir, Mmus\Iglon5, Mmus\Vsig8, Mmus\Hepacam2, Mmus\Igsf5, Mmus\Ntm, Mmus\Igsf11" "Hsap\NEGR1, Hsap\CXADR, Hsap\MXRA8, Hsap\VSIG8, Hsap\CLMP, Hsap\SIGLEC15, Hsap\GPA33, Hsap\ESAM, Hsap\VSIG2, Hsap\LSAMP, Hsap\OPCML, Hsap\JAM2, Hsap\JAM3, Hsap\IGLON5, Hsap\IGSF11, Hsap\C1orf204, Hsap\F11R, Hsap\IGSF5, Hsap\NTM, Hsap\VSIG1, Hsap\C10orf54" "gravitaxis defective,viable,visible,partially lethal - majority die,some die during pupal stage" trichogen cell DRSC14563 K -0.037482181 0.020583236 -0.135663034 -0.190642201 2.445820845 -0.480378421 FBgn0025578 Lcp9 Larval cuticle protein 9 http://flybase.org/reports/FBgn0025578 FBgn0035062 protein_coding_gene structural constituent of chitin-based larval cuticle ; GO:0008010 | inferred from sequence model structural constituent of chitin-based larval cuticle ; GO:0008010 | non-traceable author statement structural constituent of cuticle ; GO:0042302 | inferred from biological aspect of ancestor with PANTHER:PTN000822475 chitin-based cuticle development ; GO:0040003 | inferred from sequence model larval chitin-based cuticle development ; GO:0008363 | non-traceable author statement extracellular region ; GO:0005576 | non-traceable author statement extracellular matrix ; GO:0031012 | inferred from sequence model "LCP9, CG16914, Lcp9, DmelLcp9, lcp9" "IPR000618:Insect cuticle protein, IPR031311:Chitin-binding type R&R consensus" CG16914 27-Aug-18 DroID_v2018_08 Drer\LOC100003040 - "Cele\F44F1.4, Cele\sdz-30, Cele\math-34" - "Mmus\2410137M14Rik, Mmus\H2-K1" - viable DRSC04287 I -0.327492265 -1.653052684 -1.240325872 0.003798219 -0.601591682 -0.666885759 FBgn0026378 Rep Rab escort protein http://flybase.org/reports/FBgn0026378 - protein_coding_gene oxidoreductase activity ; GO:0016491 | inferred from electronic annotation with InterPro:IPR023753 GDP-dissociation inhibitor activity ; GO:0005092 | inferred from electronic annotation with InterPro:IPR018203 oxidation-reduction process ; GO:0055114 | inferred from electronic annotation with InterPro:IPR023753 intracellular protein transport ; GO:0006886 | inferred from electronic annotation with InterPro:IPR001738 small GTPase mediated signal transduction ; GO:0007264 | inferred from electronic annotation with InterPro:IPR018203 neurotransmitter secretion ; GO:0007269 | non-traceable author statement protein geranylgeranylation ; GO:0018344 | inferred from direct assay vesicle-mediated transport ; GO:0016192 | non-traceable author statement perinuclear region of cytoplasm ; GO:0048471 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from sequence or structural similarity with UniProtKB:P32864 synaptic vesicle ; GO:0008021 | non-traceable author statement aster ; GO:0005818 | inferred from direct assay membrane ; GO:0016020 | inferred from sequence or structural similarity with UniProtKB:P32864 spindle pole ; GO:0000922 | inferred from direct assay Rab-protein geranylgeranyltransferase complex ; GO:0005968 | colocalizes_with inferred from direct assay "REP, CG8432, Rep" "IPR018203:GDP dissociation inhibitor, IPR001738:Rab protein geranylgeranyltransferase component A, IPR023753:FAD/NAD(P)-binding domain" CG8432 27-Aug-18 DroID_v2018_08 Drer\chm "Scer\GDI1, Scer\MRS6" Cele\rep-1 Xtro\chm "Mmus\Chm, Mmus\Chml" "Hsap\CHML, Hsap\CHM" "lethal - all die before end of pupal stage,some die during pupal stage" DRSC07526 K -0.486307421 -0.918564052 -0.99137153 -0.791171118 2.081170851 -0.613765693 FBgn0013746 alien alien http://flybase.org/reports/FBgn0013746 "FBgn0027056, FBgn0063164" protein_coding_gene ligand-dependent nuclear receptor binding ; GO:0016922 | inferred from physical interaction with EcR transcription corepressor activity ; GO:0003714 | inferred from direct assay protein homodimerization activity ; GO:0042803 | inferred from physical interaction with alien nuclear hormone receptor binding ; GO:0035257 | inferred from physical interaction with EcR protein binding ; GO:0005515 | inferred from physical interaction with CSN5 inferred from physical interaction with CSN7 "regulation of cell cycle ; GO:0051726 | inferred from direct assay phagocytosis ; GO:0006909 | inferred from mutant phenotype protein deneddylation ; GO:0000338 | inferred from sequence or structural similarity with HGNC:30747 neurogenesis ; GO:0022008 | inferred from mutant phenotype mitotic G2 DNA damage checkpoint ; GO:0007095 | inferred from genetic interaction with nbs female germ-line stem cell population maintenance ; GO:0036099 | inferred from mutant phenotype germ cell development ; GO:0007281 | inferred from mutant phenotype negative regulation of transcription, DNA-templated ; GO:0045892 | inferred from direct assay germarium-derived cystoblast division ; GO:0048142 | inferred from mutant phenotype protein stabilization ; GO:0050821 | inferred from mutant phenotype male germ-line cyst encapsulation ; GO:0048140 | inferred from mutant phenotype multicellular organism development ; GO:0007275 | inferred from mutant phenotype" cytoplasm ; GO:0005737 | inferred from direct assay COP9 signalosome ; GO:0008180 | inferred from direct assay COP9 signalosome ; GO:0008180 | non-traceable author statement COP9 signalosome ; GO:0008180 | inferred from direct assay inferred from physical interaction with CSN5 inferred from physical interaction with CSN7 repressor ecdysone receptor complex ; GO:0008231 | inferred from physical interaction with EcR "Dch2, CSN2, Alien, DCH2, CH2, CG9556, BcDNA:LD10463, alien, Csn2" "IPR000717:Proteasome component (PCI) domain, IPR011991:Winged helix-turn-helix DNA-binding domain, IPR011990:Tetratricopeptide-like helical domain" CG9556 27-Aug-18 DroID_v2018_08 Drer\cops2 Scer\RPN6 Cele\csn-2 Xtro\cops2 Mmus\Cops2 Hsap\COPS2 embryonic stage " apodeme &&of pharynx

, abdominal 1--7 intrasegmental apodeme 2

, intersegmental apodeme

, intrasegmental apodeme

, abdominal 1--7 intersegmental apodeme

, abdominal 1--7 intrasegmental apodeme 1

" "lethal,neuroanatomy defective,visible,partially lethal - majority die,some die during pupal stage" "ganglion mother cell,trichogen cell,mesothoracic tergum" DRSC03482 K -0.360968071 -0.198849767 -0.142635149 0.796914536 1.889659677 3.183688602 FBgn0024330 MED6 Mediator complex subunit 6 http://flybase.org/reports/FBgn0024330 "FBgn0027700, FBgn0037748, FBgn0063159" protein_coding_gene protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:P91641 inferred from physical interaction with UniProtKB:Q9V439 RNA polymerase II transcription cofactor activity ; GO:0001104 | inferred from mutant phenotype RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly ; GO:0001128 | inferred from biological aspect of ancestor with PANTHER:PTN000318543 RNA polymerase II transcription cofactor activity ; GO:0001104 | inferred from sequence or structural similarity protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q8IH24 inferred from physical interaction with UniProtKB:Q9VS38 inferred from physical interaction with UniProtKB:Q9VT57 inferred from physical interaction with UniProtKB:Q9W0P8 transcription coactivator activity ; GO:0003713 | contributes_to inferred from direct assay negative regulation of neuroblast proliferation ; GO:0007406 | inferred from mutant phenotype transcription from RNA polymerase II promoter ; GO:0006366 | inferred from mutant phenotype defense response to Gram-negative bacterium ; GO:0050829 | inferred from mutant phenotype lateral inhibition ; GO:0046331 | inferred from mutant phenotype RNA polymerase II transcriptional preinitiation complex assembly ; GO:0051123 | inferred from biological aspect of ancestor with PANTHER:PTN000318543 regulation of transcription from RNA polymerase II promoter ; GO:0006357 | inferred from direct assay transcription initiation from RNA polymerase II promoter ; GO:0006367 | inferred from sequence or structural similarity negative regulation of innate immune response ; GO:0045824 | inferred from mutant phenotype mediator complex ; GO:0016592 | inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay mediator complex ; GO:0016592 | inferred from mutant phenotype cytoplasm ; GO:0005737 | inferred from direct assay core mediator complex ; GO:0070847 | inferred from biological aspect of ancestor with PANTHER:PTN000318543 mediator complex ; GO:0016592 | inferred from sequence or structural similarity "Med6, dMED6, p35, dTRAP32, dMed6, anon-EST:Posey279, Trap32, CG9473, BcDNA:LD15729, MED6, med6" "IPR007018:Mediator complex, subunit Med6, IPR016820:Mediator complex, subunit Med6, metazoa/plant" CG9473 27-Aug-18 DroID_v2018_08 Drer\med6 Scer\MED6 "Cele\mdt-6, Cele\sna-1" Xtro\med6 Mmus\Med6 Hsap\MED6 "viable,fertile,visible,partially lethal - majority die,some die during pupal stage,female sterile,germline clone,recessive,cell lethalcell lethal,somatic clone,lethal - all die before end of larval stage,some die during third instar larval stage,lethal" "chaeta,supernumerary,trichogen cell,mesothoracic tergum,follicle cell,somatic clone,eye,imaginal disc,wing disc" DRSC16500 IK 0.112603655 2.266391193 -0.306104213 0.129206078 1.546150606 0.348712307 FBgn0267821 da daughterless http://flybase.org/reports/FBgn0267821 protein_coding_gene "sequence-specific DNA binding ; GO:0043565 | inferred from direct assay protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with ac inferred from physical interaction with l(1)sc inferred from physical interaction with sc RNA polymerase II regulatory region sequence-specific DNA binding ; GO:0000977 | contributes_to inferred from physical interaction with ase inferred from physical interaction with l(1)sc inferred from physical interaction with sc protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with amos protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with ase inferred from physical interaction with l(1)sc inferred from physical interaction with sc protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with HLH54F RNA polymerase II transcription factor activity, sequence-specific DNA binding ; GO:0000981 | contributes_to inferred from physical interaction with ato protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with l(1)sc protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with ac inferred from physical interaction with emc inferred from physical interaction with l(1)sc inferred from physical interaction with sc transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ; GO:0001077 | contributes_to inferred from physical interaction with sc transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ; GO:0001077 | inferred from direct assay protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with l(1)sc inferred from physical interaction with sc RNA polymerase II regulatory region sequence-specific DNA binding ; GO:0000977 | contributes_to inferred from physical interaction with ey transcription factor binding ; GO:0008134 | inferred from genetic interaction with E(spl)m7-HLH inferred from genetic interaction with E(spl)mγ-HLH RNA polymerase II core promoter proximal region sequence-specific DNA binding ; GO:0000978 | inferred from biological aspect of ancestor with PANTHER:PTN000927455 protein homodimerization activity ; GO:0042803 | inferred from physical interaction with da transcription factor activity, sequence-specific DNA binding ; GO:0003700 | inferred from direct assay protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with ato bHLH transcription factor binding ; GO:0043425 | inferred from biological aspect of ancestor with PANTHER:PTN000927455 DNA binding ; GO:0003677 | traceable author statement protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with UniProtKB:P10627 RNA polymerase II regulatory region DNA binding ; GO:0001012 | contributes_to inferred from physical interaction with amos" "neurogenesis ; GO:0022008 | inferred from mutant phenotype peripheral nervous system development ; GO:0007422 | non-traceable author statement chaeta morphogenesis ; GO:0008407 | inferred from mutant phenotype sex determination ; GO:0007530 | traceable author statement peripheral nervous system development ; GO:0007422 | traceable author statement positive regulation of transcription, DNA-templated ; GO:0045893 | inferred from direct assay sex determination, primary response to X:A ratio ; GO:0007541 | traceable author statement ovarian follicle cell development ; GO:0030707 | traceable author statement nervous system development ; GO:0007399 | traceable author statement somatic stem cell population maintenance ; GO:0035019 | inferred from mutant phenotype sex determination ; GO:0007530 | non-traceable author statement oogenesis ; GO:0048477 | inferred from mutant phenotype Malpighian tubule tip cell differentiation ; GO:0061382 | inferred from mutant phenotype positive regulation of neuron differentiation ; GO:0045666 | inferred from biological aspect of ancestor with PANTHER:PTN000927455 positive regulation of transcription, DNA-templated ; GO:0045893 | traceable author statement second mitotic wave involved in compound eye morphogenesis ; GO:0016330 | traceable author statement neuron fate commitment ; GO:0048663 | inferred from mutant phenotype R8 cell fate specification ; GO:0045464 | non-traceable author statement oogenesis ; GO:0048477 | traceable author statement cellular response to DNA damage stimulus ; GO:0006974 | inferred from mutant phenotype sensory organ development ; GO:0007423 | inferred from mutant phenotype inferred from genetic interaction with sens inferred from genetic interaction with sc neuroendocrine cell differentiation ; GO:0061101 | inferred from mutant phenotype positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 | inferred from mutant phenotype" nucleus ; GO:0005634 | inferred from direct assay transcription factor complex ; GO:0005667 | inferred from physical interaction with l(1)sc "da, Da, CG5102, l(2)31Ea, bHLHb22, 5102, DA, l(2)k08611, SC_DA" "IPR011598:Myc-type, basic helix-loop-helix (bHLH) domain" CG5102 27-Aug-18 DroID_v2018_08 "Drer\tcf3a, Drer\LOC101883970, Drer\tcf3b, Drer\tcf4, Drer\tcf12" - Cele\hlh-2 "Xtro\tcf4, Xtro\tcf12, Xtro\tcf3" "Mmus\Tcf12, Mmus\Tcf3, Mmus\Tcf4" "Hsap\TCF3, Hsap\TCF12, Hsap\TCF4" DRSC03517 K -0.214533458 -0.481346584 -0.38401039 -0.59714716 1.88625726 0.524335697 FBgn0003430 slp1 sloppy paired 1 http://flybase.org/reports/FBgn0003430 FBgn0010610 protein_coding_gene "transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ; GO:0003705 | inferred from direct assay enhancer sequence-specific DNA binding ; GO:0001158 | inferred from direct assay" "regulation of gene expression ; GO:0010468 | inferred from mutant phenotype anterior/posterior axis specification, embryo ; GO:0008595 | non-traceable author statement mesoderm formation ; GO:0001707 | traceable author statement blastoderm segmentation ; GO:0007350 | traceable author statement specification of segmental identity, head ; GO:0007380 | inferred from expression pattern inferred from mutant phenotype inferred from genetic interaction with bcd inferred from genetic interaction with ems inferred from genetic interaction with Kr inferred from genetic interaction with Raf inferred from genetic interaction with rl inferred from genetic interaction with tor inferred from genetic interaction with tsl inferred from genetic interaction with dl heart formation ; GO:0060914 | inferred from mutant phenotype heart development ; GO:0007507 | traceable author statement negative regulation of transcription from RNA polymerase II promoter ; GO:0000122 | inferred from direct assay" nucleus ; GO:0005634 | inferred from direct assay "slp, Slp, Slp1, CG16738, Dmslp1, Slp-1, slp-2, slp-1, FD6, l(2)05965, slp1, FoxG, SLP, sko1, SLP1" "IPR018122:Fork head domain conserved site1, IPR001766:Fork head domain, IPR011991:Winged helix-turn-helix DNA-binding domain, IPR030456:Fork head domain conserved site 2" CG16738 27-Aug-18 DroID_v2018_08 "Drer\foxq2, Drer\foxk2, Drer\foxd2, Drer\foxd3, Drer\foxg1b, Drer\foxk1, Drer\foxg1a, Drer\foxg1c, Drer\foxb2, Drer\foxj1a, Drer\foxl1, Drer\foxb1b, Drer\foxb1a, Drer\foxg1d, Drer\si:ch211-262e15.1" "Scer\FHL1, Scer\HCM1, Scer\FKH2, Scer\FKH1" "Cele\fkh-9, Cele\pes-1, Cele\lin-31, Cele\fkh-2, Cele\fkh-10, Cele\unc-130" "Xtro\foxd4l1.1, Xtro\foxi4.2, Xtro\foxe3, Xtro\foxj1.2, Xtro\foxd3, Xtro\foxk2, Xtro\foxe1, Xtro\foxb1, Xtro\foxd2, Xtro\foxj1" "Mmus\Foxb1, Mmus\Foxg1, Mmus\Foxk1, Mmus\Foxb2, Mmus\Foxj1, Mmus\Foxl1, Mmus\Foxd3, Mmus\Foxk2" "Hsap\FOXG1, Hsap\FOXL1, Hsap\FOXB2, Hsap\FOXK1, Hsap\FOXJ1, Hsap\FOXB1, Hsap\FOXK2, Hsap\FOXD4, Hsap\FOXD3" " embryonic stage , embryonic stage | stage >7 , embryonic stage | stage 4 , embryonic stage | stage 4 | late , embryonic stage | stage 6 , embryonic stage | stage >=13 , embryonic stage | stage 5 " "

segment polarity , mandibular segment

,

70-100% egg length , organism | pair rule

, intercalary segment

,

71-87% egg length & ventral , labral segment

, embryonic/larval proventriculus

, ventral nerve cord

, embryonic procephalic segment | lateral

,

70-81% egg length & dorsal , organism | even pair rule

, organism | gap

" " embryonic stage | stage 8-11 , embryonic stage | stage 9-11 , embryonic stage | stage 5 , embryonic stage | stage 6,7 " " procephalic neurogenic region && embryonic antennal segment | restricted

, deuterocerebral neuroblast | subset

, procephalic neurogenic region &&of embryonic ocular segment | restricted

, organism | even pair rule

, procephalic neurogenic region && embryonic mandibular segment | restricted

, procephalic neurogenic region && labral segment | restricted

, tritocerebral neuroblast | subset

, protocerebral neuroblast | subset

, procephalic neurogenic region && intercalary segment | restricted

,

segment polarity " "lethal - all die before end of embryonic stage,some die during embryonic stage,lethal,recessive,segment polarity phenotype,cell migration defective,viable,visible,body color defective" "cuticle,denticle belt,lateral process,ventral arm of lacinia,hypostomal sclerite,embryonic/larval dorsal vessel,abdominal 2 ventral denticle belt,abdominal 4 ventral denticle belt,abdominal 6 ventral denticle belt,abdominal 8 ventral denticle belt,RP2 motor neuron,ectopic,RP2sib neuron,neuroblast NB4-2,neuroblast NB5-3,neuroblast NB3-5,neuroblast NB5-6,embryonic labial segment,embryonic/first instar larval cuticle & abdominal segment 1,embryonic/first instar larval cuticle & abdominal segment 3,embryonic/first instar larval cuticle & abdominal segment 5,embryonic/first instar larval cuticle & abdominal segment 7,embryonic/first instar larval cuticle & mesothoracic segment,head,embryonic head,mandibular segment,labial segment,abdominal segment 1,abdominal segment 2,abdominal segment 3,abdominal segment 4,visceral mesoderm,longitudinal visceral muscle primordium | embryonic stage 12,trichogen cell,mesothoracic tergum" FBgn0010433 ato atonal http://flybase.org/reports/FBgn0010433 - protein_coding_gene "protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with da RNA polymerase II transcription factor activity, sequence-specific DNA binding ; GO:0000981 | contributes_to inferred from physical interaction with da" "oenocyte development ; GO:0007438 | inferred from mutant phenotype neuron recognition ; GO:0008038 | inferred from mutant phenotype R8 cell fate specification ; GO:0045464 | traceable author statement sensory perception of sound ; GO:0007605 | inferred from mutant phenotype antennal joint morphogenesis ; GO:0048801 | inferred from mutant phenotype dendrite morphogenesis ; GO:0048813 | inferred from mutant phenotype cell fate commitment ; GO:0045165 | inferred from mutant phenotype R8 cell differentiation ; GO:0045465 | traceable author statement sensory organ precursor cell fate determination ; GO:0016360 | traceable author statement second mitotic wave involved in compound eye morphogenesis ; GO:0016330 | traceable author statement sensory organ development ; GO:0007423 | traceable author statement male courtship behavior, veined wing generated song production ; GO:0045433 | inferred from mutant phenotype sensory organ precursor cell fate determination ; GO:0016360 | inferred from direct assay optic lobe placode development ; GO:0001748 | inferred from mutant phenotype positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 | inferred from expression pattern eye-antennal disc morphogenesis ; GO:0007455 | inferred from mutant phenotype compound eye morphogenesis ; GO:0001745 | traceable author statement R8 cell fate commitment ; GO:0007460 | inferred from mutant phenotype brain development ; GO:0007420 | inferred from mutant phenotype activation of MAPK activity ; GO:0000187 | traceable author statement Bolwig's organ morphogenesis ; GO:0001746 | inferred from expression pattern R8 cell fate specification ; GO:0045464 | non-traceable author statement sensory organ precursor cell fate determination ; GO:0016360 | inferred from mutant phenotype antennal morphogenesis ; GO:0048800 | inferred from mutant phenotype neuron development ; GO:0048666 | inferred from mutant phenotype epidermal growth factor receptor signaling pathway ; GO:0007173 | inferred from genetic interaction with Egfr smoothened signaling pathway ; GO:0007224 | inferred from genetic interaction with hh sensory organ development ; GO:0007423 | inferred from mutant phenotype peripheral nervous system development ; GO:0007422 | non-traceable author statement nervous system development ; GO:0007399 | traceable author statement" nucleus ; GO:0005634 | inferred from direct assay "ATO, ato1, CG7508, ato, At, Ato, bHLHa10, ato[Dm]" "IPR011598:Myc-type, basic helix-loop-helix (bHLH) domain, IPR032664:Protein atonal/amos/lin-32" CG7508 27-Aug-18 DroID_v2018_08 "Drer\atoh7, Drer\neurod1, Drer\atoh1c, Drer\atoh1b, Drer\neurod6b, Drer\atoh1a, Drer\neurod4, Drer\neurod6a" - "Cele\cnd-1, Cele\lin-32" "Xtro\atoh7, Xtro\atoh1, Xtro\neurod6, Xtro\neurod4" "Mmus\Neurod1, Mmus\Neurod6, Mmus\Atoh7, Mmus\Neurod4, Mmus\Atoh1" "Hsap\ATOH1, Hsap\NEUROD6, Hsap\ATOH7, Hsap\NEUROD4, Hsap\NEUROD1" " embryonic stage | stage 13 , larval stage | third instar , embryonic stage , larval stage--pupal stage " " embryonic central brain | restricted

, larval protocerebrum

, C1 chordotonal organ precursor cell

, chordotonal organ

, external sensory organ

, eye-antennal disc

, prothoracic chordotonal organ

, chordotonal organ &&of wing

, chordotonal organ of tegula

, morphogenetic furrow

, mesothoracic femoral chordotonal organ

, ventral thoracic disc

, inner proliferation zone

, chordotonal organ of scabellum

, Johnston's organ

" " embryonic stage | stage 9-11 , embryonic stage | stage 13 , adult stage , embryonic stage | stage 8-10 " " deuterocerebral neuroblast | subset

, embryonic ganglion mother cell

, protocerebral neuroblast | subset

, adult brain | restricted

, procephalic neurogenic region &&of embryonic antennal segment | restricted

, procephalic neurogenic region &&of embryonic ocular segment | restricted

, embryonic central brain | restricted

" "neuroanatomy defective,thermotaxis behavior defective,wild-type,recessive,somatic clone,touch sensitivity defective,visible,locomotor behavior defective,song defective,auditory perception defective,neurophysiology defective,partially lethal - majority die,visual behavior defective,behavior defective,uncoordinated,lethal - all die before end of P-stage,some die during pharate adult stage,viable" "eye,neurite,dendrite | adult stage,T neuron T4,T neuron T5,chordotonal organ of wing,supernumerary,ommatidium,photoreceptor cell R8,heat sensitive,photoreceptor cell,somatic clone,antennal segment 3 & fasciclep13),neuron of aristal sensillum,antennal lobe glomerulus,glial cell,antenna,antennal lobe,glial cell & antennap13),sensillum coeloconicum of antennal segment 3,glial cell & antennal lobep13),interneuron & antennal lobep13),pioneer neuron & adult antennal nerve & pupap13),abdominal lateral pentascolopidial chordotonal organ lch5,embryonic/larval oenocyte,sacculus,embryonic/larval oenocyte precursor,oenocyte primordium,C1 chordotonal organ precursor cell,third segment of antenna,Johnston organ,eye photoreceptor cell,eye photoreceptor cell & axon,morphogenetic furrow & filopodium | somatic clone,eye disc,sensillum coeloconicum,abdominal 1 lateral pentascolopidial chordotonal organ lch5,abdominal 2 lateral pentascolopidial chordotonal organ lch5,abdominal 3 lateral pentascolopidial chordotonal organ lch5,abdominal 4 lateral pentascolopidial chordotonal organ lch5,abdominal 5 lateral pentascolopidial chordotonal organ lch5,abdominal 6 lateral pentascolopidial chordotonal organ lch5,abdominal 7 lateral pentascolopidial chordotonal organ lch5,maxillary palp sensillum basiconicum,basiconic sensillum of sacculus,adult antennal nerve,chordotonal organ,scolopidial neuron,eye-antennal disc,morphogenetic furrow,embryonic/larval brain,adult brain,wing,cholinergic neuron,antenna & neuron,Bolwig organ,sensory mother cell,sensory mother cell & antennal disc,ocellus,interommatidial bristle,optic lobe,ommatidial precursor cluster,embryonic antennal sense organ,olfactory neuron & embryonic antennal sense organ,lch5 neuron,chordotonal organ precursor cell & ventral thoracic disc,mitotic cell cycle & eye disc | somatic clone,external sensory organ,ectopic,macrochaeta,photoreceptor cell R7,scutellar bristle,wing vein L3,scutum,adult thorax & macrochaeta109,abdominal sternite bristle,wing sensillum,campaniform sensillum of anterior crossvein,sensory mother cell & dorsal mesothoracic disc109,sensory mother cell & dorsal mesothoracic discptc-559.1,adult head,sensillum basiconicum,sensillum trichodeum,sensillum basiconicum of antennal segment 3,lobula,medulla,optic chiasma,abdominal basiconical sensillum dbd & larva & nerve terminal.PC,multidendritic neuron,macrochaeta & wing | ectopicdpp.blk1,chordotonal organ & wing | ectopicdpp.blk1,sternopleural bristle" FBgn0004170 sc scute http://flybase.org/reports/FBgn0004170 "FBgn0003324, FBgn0003412, FBgn0026842" protein_coding_gene "sequence-specific DNA binding ; GO:0043565 | inferred from direct assay transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ; GO:0001077 | contributes_to inferred from physical interaction with da protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with da protein binding ; GO:0005515 | inferred from physical interaction with Bap60 transcription factor activity, sequence-specific DNA binding ; GO:0003700 | inferred from sequence or structural similarity with l(1)sc sequence-specific DNA binding ; GO:0043565 | contributes_to inferred from physical interaction with da sequence-specific DNA binding ; GO:0043565 | contributes_to inferred from direct assay RNA polymerase II regulatory region sequence-specific DNA binding ; GO:0000977 | contributes_to inferred from physical interaction with da transcription factor binding ; GO:0008134 | inferred from genetic interaction with E(spl)m7-HLH inferred from genetic interaction with E(spl)mγ-HLH" "nervous system development ; GO:0007399 | traceable author statement chaeta morphogenesis ; GO:0008407 | inferred from mutant phenotype central nervous system development ; GO:0007417 | traceable author statement sex determination ; GO:0007530 | inferred from mutant phenotype positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 | inferred from mutant phenotype sex determination, establishment of X:A ratio ; GO:0007540 | non-traceable author statement negative regulation of apoptotic process ; GO:0043066 | inferred from mutant phenotype sex determination ; GO:0007530 | traceable author statement chaeta development ; GO:0022416 | inferred from mutant phenotype regulation of transcription, DNA-templated ; GO:0006355 | inferred from sequence or structural similarity with l(1)sc regulation of mitotic cell cycle ; GO:0007346 | traceable author statement regulation of transcription, DNA-templated ; GO:0006355 | non-traceable author statement neuroblast fate determination ; GO:0007400 | traceable author statement sex determination ; GO:0007530 | inferred from genetic interaction with Sxl ventral cord development ; GO:0007419 | non-traceable author statement regulation of glucose metabolic process ; GO:0010906 | inferred from mutant phenotype Malpighian tubule tip cell differentiation ; GO:0061382 | inferred from mutant phenotype peripheral nervous system development ; GO:0007422 | traceable author statement regulation of neurogenesis ; GO:0050767 | inferred from biological aspect of ancestor with PANTHER:PTN000358354 sensory organ development ; GO:0007423 | inferred from mutant phenotype nervous system development ; GO:0007399 | inferred from genetic interaction with sisA sex determination ; GO:0007530 | inferred from genetic interaction with dpn inferred from genetic interaction with dpn, Sxl chaeta morphogenesis ; GO:0008407 | non-traceable author statement peripheral nervous system development ; GO:0007422 | inferred from mutant phenotype" transcription factor complex ; GO:0005667 | inferred from physical interaction with da RNA polymerase II transcription factor complex ; GO:0090575 | inferred from biological aspect of ancestor with PANTHER:PTN000358347 "sc, sis-b, sisB, Sc, EG:198A6.1, CG3827, scalpha, DROACS2, T4, T4 AS-C, scute/sisterlessB, sis b, sisb, AS-C T4sc, Hw, AS-C T4, ascT4, sc/T4, l(1)1Ba, bHLHc28, SC_DA" "IPR011598:Myc-type, basic helix-loop-helix (bHLH) domain, IPR015660:Achaete-scute transcription factor-related" CG3827 27-Aug-18 DroID_v2018_08 "Drer\nhlh2, Drer\tcf23, Drer\tal2, Drer\msc, Drer\mespab, Drer\tcf15, Drer\figla, Drer\mespba, Drer\scxa, Drer\lyl1, Drer\msgn1, Drer\tal1, Drer\ptf1a, Drer\tcf21, Drer\hand2, Drer\ascl1b, Drer\ascl1a, Drer\scxb, Drer\mespaa, Drer\si:ch211-246m6.4, Drer\tcf24" - "Cele\hlh-3, Cele\hlh-14" "Xtro\ptf1a, Xtro\tcf15, Xtro\ascl3, Xtro\hand2, Xtro\msgn1, Xtro\mespb, Xtro\figla, Xtro\hand1, Xtro\lyl1, Xtro\tcf21, Xtro\scx, Xtro\mespa, Xtro\nhlh1, Xtro\msc, Xtro\tal1, Xtro\ascl2" "Mmus\Hand1, Mmus\Tcf15, Mmus\Nhlh2, Mmus\Ascl4, Mmus\Ascl1, Mmus\Ascl5, Mmus\Msc, Mmus\Figla, Mmus\Ferd3l, Mmus\Mesp2, Mmus\Ascl2, Mmus\Lyl1, Mmus\Nhlh1, Mmus\Tal1, Mmus\Msgn1, Mmus\Tal2, Mmus\Ptf1a, Mmus\Tcf23, Mmus\Hand2, Mmus\Tcf21, Mmus\Ascl3, Mmus\Mesp1, Mmus\Scx" "Hsap\TCF24, Hsap\TCF21, Hsap\ASCL4, Hsap\MESP1, Hsap\ASCL2, Hsap\MESP2, Hsap\MSGN1, Hsap\HAND2, Hsap\NHLH1, Hsap\ASCL3, Hsap\FIGLA, Hsap\ASCL1, Hsap\MSC, Hsap\HAND1, Hsap\TAL1, Hsap\NHLH2, Hsap\PTF1A, Hsap\TAL2, Hsap\TCF23, Hsap\SCX, Hsap\TCF15, Hsap\LYL1, Hsap\ASCL5" " embryonic stage ,, larval stage | third instar , larval stage | third instar stage 2 , pupal stage , embryonic stage | cycle 9-13 , embryonic stage | 0-12hr " " labral segment

, neuroblast

, stomodeum

, proneural cluster

, dorsal mesothoracic disc | restricted

, neurogenic region

, ectoderm

, dorsal mesothoracic disc

, embryonic peripheral nervous system

, sensory mother cell

, posterior embryonic/larval midgut

, central nervous system

, adult trachea | precursor

, cleavage nucleus

, ventral midline

, cephalic furrow

, sensory organ cell

, procephalic neuroblast

, procephalic segment

" " embryonic stage , larval stage , larval stage | third instar , embryonic stage | stage 10-11 , embryonic stage | stage 9-11 , embryonic stage | stage 12-14 , embryonic stage -- adult stage " " embryonic/larval hindgut | restricted

, embryonic peripheral nervous system | restricted

, proneural cluster

, dorsal mesothoracic disc | restricted

, sensory mother cell

, embryonic central nervous system

, ectoderm

, procephalic neuroblast | subset

, protocerebral neuroblast | subset

, embryonic stomatogastric nervous system

, neuroblast

, ventral neurogenic region

, wing vein L1

, C1 chordotonal organ precursor cell

, dorsal mesothoracic disc

, procephalic neurogenic region | restricted

, deuterocerebral neuroblast | subset

" "viable,male,reduced,fertile,visible,male sterile,recessive,female sterile,female,lethal,wild-type,male fertile,female fertile,partially lethal - majority die,heat sensitive,sex-determination defective,lethal - all die before end of embryonic stage,some die during embryonic stage,dominant,female limited,partially lethal - majority live,mitotic cell cycle defective,sterile,lethal - all die before end of P-stage,some die during pharate adult stage,flightless" "humeral bristle,postvertical bristle,ocellar bristle,scutellar bristle,anterior orbital bristle,anterior notopleural bristle,presutural bristle,anterior postalar bristle,anterior supraalar bristle,posterior postalar bristle,macrochaeta,ectopic,mesothoracic tergum,wing,mesothoracic tarsal bristle,mesothoracic tarsal bristle longitudinal row 6.5,mesothoracic tarsal bristle longitudinal row 6,anterior dorsocentral bristle,middle orbital bristle,heat sensitive,chaeta,tergite,notal microchaeta,supernumerary,prothoracic leg sensillum,mesothoracic leg sensillum,metathoracic leg sensillum,macrochaeta & leg,head,male,third segment of antenna,mesothoracic tergum & macrochaeta,posterior orbital bristle,posterior supraalar bristle,posterior notopleural bristle,dorsocentral bristle,proboscis & macrochaeta,upper humeral bristle,notopleural bristle,lower humeral bristle,orbital bristle,anterior vertical bristle,supraalar bristle,postalar bristle,sensillum campaniformium of dorsal radius Sc4d,vertical bristle,abdomen,abdominal sternite bristle,sternopleural bristle,anepisternum,posterior vertical bristle,microchaeta,anterior scutellar bristle,mesothoracic tarsal bristle longitudinal row 5.5,mesothoracic tarsal bristle longitudinal row 5,head bristle,posterior dorsocentral bristle,mechanosensory chaeta,posterior scutellar bristle,sternite,wing disc,sensory mother cell,sense organ,dorsal row & glial cell,ventral row & glial cell,anterior notal wing process sensillum campaniformium & glial cell,sensillum campaniformium of anterior crossvein & glial cell,sensillum campaniformium of dorsal radius & glial cell,mesothoracic metatarsus,wing sensillum,dorsal row,ventral row,eo neuron,tormogen cell,medial triple row,adult thoracic sensillum,external sensory organ,wing & external sensory organhs.PB,wing vein L2,multidendritic neuron,scutellum & microchaeta109,wing vein L3,scutum,sensory mother cell & dorsal mesothoracic disc109,sensory mother cell & dorsal mesothoracic discptc-559.1,mesothoracic tergum & macrochaeta | ectopic-C253,haltere,wing & macrochaetadpp.blk1,haltere sensillum,haltere & macrochaetadpp.blk1,macrochaeta & scutellum455.2,adult thorax & microchaetaap-md544,adult thorax & macrochaetaap-md544,mesothoracic tergum & macrochaeta | ectopicap-md544,dorsal medial muscle,chaeta | ectopic & mesothoracic tergumC-765" FBgn0046680 anon-38B.8 anon-38B.8 http://flybase.org/reports/FBgn0046680 gene - - - "38B.8, anon-38B.8" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0001150 gt giant http://flybase.org/reports/FBgn0001150 - protein_coding_gene "protein homodimerization activity ; GO:0042803 | inferred from sequence or structural similarity transcription factor activity, sequence-specific DNA binding ; GO:0003700 | inferred from direct assay RNA polymerase II distal enhancer sequence-specific DNA binding ; GO:0000980 | inferred from direct assay transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ; GO:0003705 | inferred from direct assay sequence-specific DNA binding ; GO:0043565 | inferred from direct assay transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ; GO:0001077 | inferred from biological aspect of ancestor with PANTHER:PTN000945219 protein heterodimerization activity ; GO:0046982 | inferred from sequence or structural similarity RNA polymerase II regulatory region sequence-specific DNA binding ; GO:0000977 | inferred from direct assay" "specification of segmental identity, labial segment ; GO:0007381 | inferred from mutant phenotype regulation of glucose metabolic process ; GO:0010906 | inferred from mutant phenotype negative regulation of transcription from RNA polymerase II promoter ; GO:0000122 | inferred from mutant phenotype regulation of cell size ; GO:0008361 | inferred from mutant phenotype zygotic determination of anterior/posterior axis, embryo ; GO:0007354 | traceable author statement ring gland development ; GO:0035271 | inferred from mutant phenotype regulation of transcription involved in anterior/posterior axis specification ; GO:0044324 | inferred from mutant phenotype salivary gland development ; GO:0007431 | traceable author statement regulation of gene expression ; GO:0010468 | inferred from mutant phenotype negative regulation of multicellular organism growth ; GO:0040015 | inferred from mutant phenotype posterior head segmentation ; GO:0035289 | traceable author statement axon guidance ; GO:0007411 | inferred from mutant phenotype phagocytosis ; GO:0006909 | inferred from mutant phenotype terminal region determination ; GO:0007362 | inferred from genetic interaction with tor negative regulation of transcription from RNA polymerase II promoter ; GO:0000122 | traceable author statement zygotic determination of anterior/posterior axis, embryo ; GO:0007354 | non-traceable author statement torso signaling pathway ; GO:0008293 | inferred from genetic interaction with tor negative regulation of transcription from RNA polymerase II promoter ; GO:0000122 | inferred from direct assay" nucleus ; GO:0005634 | inferred from direct assay "gt, Giant, EG:BACH7M4.5, CG7952, GIAN_DROME, l(1)giant, l(1)3Aa, Gt, GT, DM17" "IPR004827:Basic-leucine zipper domain, IPR029859:Protein giant, IPR015943:WD40/YVTN repeat-like-containing domain" CG7952 27-Aug-18 DroID_v2018_08 "Drer\dbpa, Drer\nfil3-5, Drer\cebp1, Drer\tefa, Drer\cebpb, Drer\si:dkey-172o19.2, Drer\tefb, Drer\dbpb, Drer\ddit3, Drer\hlfb, Drer\hlfa, Drer\nfil3-2, Drer\nfil3-4" - "Cele\zip-6, Cele\zip-7, Cele\atf-8, Cele\ces-2" "Xtro\hlf, Xtro\dbp, Xtro\cebpb" "Mmus\Tef, Mmus\Cebpe, Mmus\Cebpb, Mmus\Cebpa, Mmus\Hlf, Mmus\Dbp" "Hsap\DBP, Hsap\TEF, Hsap\HLF, Hsap\CEBPA" " embryonic stage | gastrulation , embryonic stage | extended germ band stage , embryonic stage | cellular blastoderm , embryonic stage | extended germ band , embryonic stage | stage 4 , embryonic stage | stage 5 , embryonic stage | embryonic cycle 13 , embryonic stage | embryonic cycle 12,13 , embryonic stage | embryonic cycle 12 " "

anterior{ + kni* } , anterior embryonic/larval midgut

{ + Kr* } ,

20-25% egg length{ 0 kni* } , labral segment

,

33-45% egg length{ 0 Kr* } ,

90-100% egg length , organism | 60-70% egg length

, organism | 70-80% egg length

, organism | 20-30% egg length

,

anterior{ 0 eve* } ,

anterior{ + hb* } ,

14-20% egg length{ 0 hb* } , organism | 60-80% egg length

, cephalic furrow

, organism | 50-90% egg length

, organism | 0-30% egg length

, organism | 90-100% egg length

,

20-40% egg length " " embryonic stage , embryonic stage | stage 5 , embryonic stage | embryonic cycle 12 , embryonic stage | embryonic cycle 13 " " maxillary segment

, organism | 90-100% egg length

, labrum

, ring gland

, organism | 20-40% egg length

, mandibular segment

, organism | 0-30% egg length

, organism | 60-80% egg length

, organism | 10-20% egg length

, organism | 60-70% egg length

, organism | 70-80% egg length

" "lethal,recessive,visible,viable,body size defective,neuroanatomy defective,lethal - all die before end of embryonic stage,some die during embryonic stage,size defective" "larval salivary gland & embryo & nuclear chromosome,prothoracic gland innervating neuron PG-LP,prothoracic gland,nucleus | third instar larval stage,mesothoracic segment,metathoracic segment,abdominal segment 2,abdominal segment 3,abdominal segment 4,abdominal segment 5,embryonic/first instar larval cuticle,salivary gland,dorsal hair,ectopic,denticle belt,embryonic labial segment,embryonic prothoracic segment,dorsal ridge,abdominal 6 ventral denticle belt,hypostomal sclerite,embryonic abdominal segment,embryonic abdominal segment 6,embryonic abdominal segment 7,peripheral nervous system,chordotonal organ,lateral,larval abdominal segment 6,larval abdominal segment 7,embryonic stomatogastric nervous system,corpus cardiacum primordium,mouth hooks,hypophysis,embryonic/larval labial organ,larval head,abdominal 5 ventral denticle belt,abdominal 7 ventral denticle belt,abdominal 8 ventral denticle belt,embryonic head,embryonic abdominal segment 5,labial segment,thorax,anterior,abdominal segment 6,abdominal segment 7,larva" FBgn0004197 Ser Serrate http://flybase.org/reports/FBgn0004197 "FBgn0003111, FBgn0003355" protein_coding_gene "calcium ion binding ; GO:0005509 | inferred from electronic annotation with InterPro:IPR001881, InterPro:IPR018097 receptor binding ; GO:0005102 | non-traceable author statement Notch binding ; GO:0005112 | traceable author statement protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q9VUX2 Notch binding ; GO:0005112 | inferred from physical interaction with N Notch binding ; GO:0005112 | non-traceable author statement protein binding ; GO:0005515 | inferred from physical interaction with mib1" "salivary gland development ; GO:0007431 | non-traceable author statement dorsal/ventral lineage restriction, imaginal disc ; GO:0007451 | traceable author statement Notch signaling pathway ; GO:0007219 | inferred from mutant phenotype crystal cell differentiation ; GO:0042688 | inferred from mutant phenotype imaginal disc-derived leg segmentation ; GO:0036011 | inferred from mutant phenotype lymph gland crystal cell differentiation ; GO:0035170 | traceable author statement imaginal disc-derived wing morphogenesis ; GO:0007476 | inferred from mutant phenotype second mitotic wave involved in compound eye morphogenesis ; GO:0016330 | inferred from mutant phenotype crystal cell differentiation ; GO:0042688 | traceable author statement negative regulation of lamellocyte differentiation ; GO:0035204 | inferred from mutant phenotype compound eye development ; GO:0048749 | inferred from mutant phenotype salivary gland morphogenesis ; GO:0007435 | inferred from mutant phenotype sensory organ development ; GO:0007423 | inferred from mutant phenotype Notch signaling pathway ; GO:0007219 | non-traceable author statement lateral inhibition ; GO:0046331 | inferred from mutant phenotype glial cell proliferation ; GO:0014009 | inferred from mutant phenotype larval salivary gland morphogenesis ; GO:0007436 | inferred from mutant phenotype compound eye development ; GO:0048749 | traceable author statement negative regulation of Notch signaling pathway ; GO:0045746 | inferred from direct assay regulation of crystal cell differentiation ; GO:0042689 | traceable author statement larval lymph gland hemopoiesis ; GO:0035167 | inferred from expression pattern germ-line stem cell population maintenance ; GO:0030718 | inferred from genetic interaction with Dl eye-antennal disc development ; GO:0035214 | inferred from mutant phenotype salivary gland morphogenesis ; GO:0007435 | non-traceable author statement cuticle pattern formation ; GO:0035017 | inferred from mutant phenotype" integral component of membrane ; GO:0016021 | inferred from electronic annotation with InterPro:IPR011651 axolemma ; GO:0030673 | inferred from direct assay cell surface ; GO:0009986 | inferred from direct assay integral component of membrane ; GO:0016021 | non-traceable author statement apical plasma membrane ; GO:0016324 | inferred from direct assay plasma membrane ; GO:0005886 | inferred from direct assay "Ser, ser, CT18858, Bd, Rpw, std, mel(3)8, CG6127, SER" "IPR018097:EGF-like calcium-binding, conserved site, IPR000152:EGF-type aspartate/asparagine hydroxylation site, IPR000742:EGF-like domain, IPR001774:Delta/Serrate/lag-2 (DSL) protein, IPR001881:EGF-like calcium-binding domain, IPR011651:Notch ligand, N-terminal domain, IPR013032:EGF-like, conserved site, IPR009030:Growth factor receptor cysteine-rich domain, IPR026219:Jagged/Serrate protein, IPR001007:VWFC domain" CG6127 27-Aug-18 DroID_v2018_08 "Drer\jag1b, Drer\jag1a, Drer\adgrf6, Drer\sned1, Drer\fbln7, Drer\LOC100332841, Drer\col28a1a, Drer\jag2b, Drer\adgrl4, Drer\scube3, Drer\LOC562634, Drer\megf6b, Drer\scube1, Drer\svep1, Drer\crb2b, Drer\jag2a, Drer\zgc:158328, Drer\matn3a, Drer\fbln1, Drer\LOC100535882, Drer\si:ch73-173h19.3, Drer\crb2a, Drer\ltbp3, Drer\dlb, Drer\col28a1a, Drer\efemp1, Drer\dpy19l1l" - Cele\apx-1 "Xtro\col14a1, Xtro\fbn1, Xtro\ltbp4, Xtro\jag1, Xtro\crb2, Xtro\f12, Xtro\nell1, Xtro\svep1, Xtro\hgfac, Xtro\notch1, Xtro\matn4" "Mmus\Ltbp4, Mmus\Matn3, Mmus\Dll4, Mmus\Col22a1, Mmus\Egfl7, Mmus\Scube2, Mmus\Crb2, Mmus\Jag2, Mmus\Vwa1, Mmus\Col28a1, Mmus\Sned1, Mmus\Vwce, Mmus\Cfc1, Mmus\Hmcn2, Mmus\F12, Mmus\Jag1, Mmus\Tdgf1, Mmus\Dlk2, Mmus\Ltbp1, Mmus\Scube3, Mmus\Fbn1, Mmus\Dll3, Mmus\Habp2, Mmus\Svep1, Mmus\Dlk1, Mmus\Hgfac, Mmus\Fbln7, Mmus\Vwde" "Hsap\F12, Hsap\COL22A1, Hsap\SCUBE3, Hsap\HGFAC, Hsap\CFC1B, Hsap\DLK1, Hsap\DLL3, Hsap\VWCE, Hsap\EYS, Hsap\LOC100996717, Hsap\SNED1, Hsap\HABP2, Hsap\CRB2, Hsap\DLL4, Hsap\LTBP1, Hsap\SVEP1, Hsap\DLK2, Hsap\NOTCH2NL, Hsap\CFC1, Hsap\TDGF1, Hsap\SCUBE2, Hsap\FBLN7, Hsap\EGFL7, Hsap\VWA1, Hsap\COL14A1, Hsap\MATN3, Hsap\JAG2, Hsap\JAG1" " embryonic stage , adult stage | female , larval stage | third instar , embryonic stage | 2-4 hr , adult stage | male " " epidermis | stripes

, embryonic/larval foregut

, alula

, stomodeum

, embryonic/larval proventriculus

, embryonic/larval salivary gland

, trachea

, maxillary lobe

, mandibular segment

, embryonic salivary gland

, embryonic/larval hindgut

, embryonic/larval posterior spiracle

, central nervous system

, embryonic/larval hypopharynx

, supraesophageal ganglion

, labial segment

, labral segment

, embryonic/larval anterior spiracle

, embryonic/larval pharynx

, maxillary segment

, frontal head air sac | ventral

, dorsal mesothoracic disc

, anal pad

, epidermis

, telson

" " embryonic stage , larval stage | third instar " " embryonic/larval posterior spiracle

, stomodeum

, dorsal mesothoracic disc

, embryonic/larval pharynx

, embryonic/larval salivary gland

, supraesophageal ganglion

, mandibular segment

, epidermis

, frontal head air sac | ventral

, embryonic/larval foregut

, commissure

, labial segment

, alula

, embryonic/larval hindgut

, trachea

, embryonic/larval anterior spiracle

, labral segment

, epidermis | stripes

, maxillary segment

, anal pad

, embryonic/larval proventriculus

" "neuroanatomy defective,visible,viable,dominant,mitotic cell cycle defective,recessive,lethal - all die before end of pupal stage,some die during pupal stage,lethal,cold sensitive,heat sensitive,lethal - all die before end of larval stage,some die during larval stage,lethal - all die before end of embryonic stage,some die during embryonic stage,somatic clone,cell polarity defective,male fertile,size defective,homeotic,lethal - all die before end of P-stage,some die during pharate adult stage,body color defective" "interface glial cell,wing vein,wing margin,wing,distal,proneural cluster,optic lobe,glial cell,haltere,mesothoracic metatarsus,mesothoracic tarsal segment 2,metathoracic tarsal segment 2,prothoracic metatarsus,prothoracic tarsal segment 2,metathoracic metatarsus,crystal cell,embryonic head,mouth hooks,leg,tibia,femur,anterior,heat sensitive,eye,cold sensitive,adult heart,embryonic/larval anterior spiracle,papilla of larval anterior spiracle,wing disc,commissure,axon,dorsal closure embryo,denticle,cuticle,dorsal hair,dorsal compartment,somatic clone,joint,leg & joint,tarsal segment 1 & joint,tarsal segment 2 & joint,tarsal segment 3 & joint,tarsal segment 4 & joint,tarsal segment 5 & joint,denticle row 3 & abdominal 2 ventral denticle belt,denticle row 4 & abdominal 2 ventral denticle belt,denticle row 3 & abdominal 3 ventral denticle belt,denticle row 4 & abdominal 3 ventral denticle belt,denticle row 3 & abdominal 4 ventral denticle belt,denticle row 4 & abdominal 4 ventral denticle belt,denticle row 3 & abdominal 5 ventral denticle belt,denticle row 4 & abdominal 5 ventral denticle belt,denticle row 3 & abdominal 6 ventral denticle belt,denticle row 4 & abdominal 6 ventral denticle belt,denticle row 3 & abdominal 7 ventral denticle belt,denticle row 4 & abdominal 7 ventral denticle belt,denticle row 3 & abdominal 8 ventral denticle belt,denticle row 4 & abdominal 8 ventral denticle belt,dorsal pouch,dorsal bridge,lateral process,embryonic/larval proventriculus,embryonic/larval digestive system,hub cell,salivary gland imaginal ring,macrochaeta,ectopic,dorsal/ventral compartment boundary,actin filament & larval salivary gland,denticle row 3,denticle row 4,adult abdominal segment 4,adult abdominal segment 5,adult abdominal segment 6,adult abdominal segment 7,procrystal cell,embryonic/larval salivary gland duct,presumptive embryonic/larval nervous system,embryonic epidermis,eye disc,dorsal,ventral,antenna,morphogenetic furrow,eye-antennal disc,supernumerary,medulla,ommatidium,interommatidial bristle,pigment cell,lens,eye photoreceptor cell,photoreceptor cell R7,ventral compartment,neuron,embryonic/larval proventriculus | embryonic stage,embryonic/larval digestive system | embryonic stage,presutural bristle & trichogen celll(3)31-1-31-1,anterior notopleural bristle & trichogen celll(3)31-1-31-1,posterior notopleural bristle & trichogen celll(3)31-1-31-1,anterior supraalar bristle & trichogen celll(3)31-1-31-1,posterior supraalar bristle & trichogen celll(3)31-1-31-1,anterior postalar bristle & trichogen celll(3)31-1-31-1,posterior postalar bristle & trichogen celll(3)31-1-31-1,anterior dorsocentral bristle & trichogen celll(3)31-1-31-1,posterior dorsocentral bristle & trichogen celll(3)31-1-31-1,anterior scutellar bristle & trichogen celll(3)31-1-31-1,microchaeta,scutum & macrochaeta & trichogen celll(3)31-1-31-1,tarsal segment,wing & macrochaetadpp.blk1,wing sensillum,macrochaeta & wingptc-559.1,dorsal row,ventral row,wing margin bristle,wing & macrochaeta | dorsalBx-MS1096,scutum & macrochaetaBx-MS1096,scutum,macrochaeta & wingh-540.3,tarsal segment 4,embryonic/larval lymph gland | larval stage,embryonic/larval lymph gland,rhabdomere,eye photoreceptor cell & eye disc | posterior-537.4,macrochaeta & thorax | supernumerary-537.4,eye photoreceptor cell & eye disch-H10,macrochaeta & scutellum | supernumerary | somatic clone | cell autonomous-109-68,macrochaeta & thorax | supernumerary | somatic cloneUbx.PdC,macrochaeta & thorax | somatic cloneUbx.PdC,trichogen cell,mesothoracic tergum" FBgn0259212 cno canoe http://flybase.org/reports/FBgn0259212 protein_coding_gene protein domain specific binding ; GO:0019904 | inferred from physical interaction with pins protein binding ; GO:0005515 | inferred from physical interaction with Ran cell adhesion molecule binding ; GO:0050839 | inferred from biological aspect of ancestor with PANTHER:PTN001624603 Ras GTPase binding ; GO:0017016 | inferred from physical interaction with Rap1 "establishment of mitotic spindle orientation ; GO:0000132 | inferred from mutant phenotype inferred from genetic interaction with Ran inferred from genetic interaction with pins Ras protein signal transduction ; GO:0007265 | traceable author statement ommatidial rotation ; GO:0016318 | inferred from mutant phenotype dorsal closure ; GO:0007391 | inferred from genetic interaction with zip, PDZ-GEF second mitotic wave involved in compound eye morphogenesis ; GO:0016330 | inferred from mutant phenotype regulation of JNK cascade ; GO:0046328 | inferred from mutant phenotype inferred from genetic interaction with bsk embryonic morphogenesis ; GO:0048598 | inferred from mutant phenotype adherens junction organization ; GO:0034332 | inferred from biological aspect of ancestor with PANTHER:PTN001624603 compound eye development ; GO:0048749 | inferred from genetic interaction with mbt dorsal closure, elongation of leading edge cells ; GO:0007394 | non-traceable author statement glial cell proliferation ; GO:0014009 | inferred from mutant phenotype regulation of protein localization ; GO:0032880 | inferred from direct assay inferred from mutant phenotype epidermis morphogenesis ; GO:0048730 | inferred from mutant phenotype cell adhesion ; GO:0007155 | inferred from biological aspect of ancestor with PANTHER:PTN001624603 regulation of JNK cascade ; GO:0046328 | non-traceable author statement JNK cascade ; GO:0007254 | non-traceable author statement establishment or maintenance of cell polarity ; GO:0007163 | non-traceable author statement Notch signaling pathway ; GO:0007219 | traceable author statement dorsal closure ; GO:0007391 | inferred from mutant phenotype dorsal closure ; GO:0007391 | traceable author statement" cell-cell junction ; GO:0005911 | inferred from electronic annotation with InterPro:IPR028842 adherens junction ; GO:0005912 | non-traceable author statement cell cortex ; GO:0005938 | inferred from direct assay zonula adherens ; GO:0005915 | traceable author statement adherens junction ; GO:0005912 | traceable author statement connecting hemi-adherens junction ; GO:0005926 | inferred from direct assay adherens junction ; GO:0005912 | inferred from direct assay adherens junction ; GO:0005912 | colocalizes_with inferred from direct assay "cno, EC3-10, CG42312, Cno, Canoe, lip, mis, dlhA, CG2534, anon-WO0172774.47, AF-6, CG31537, canoe, cno?" "IPR000159:Ras-associating (RA) domain, IPR000253:Forkhead-associated (FHA) domain, IPR001478:PDZ domain, IPR002710:Dilute domain, IPR008984:SMAD/FHA domain, IPR029071:Ubiquitin-related domain, IPR028842:Afadin" CG42312 27-Aug-18 DroID_v2018_08 "Drer\radil, Drer\rasip1, Drer\mllt4a" Scer\SEC3 Cele\afd-1 "Xtro\mllt4, Xtro\rasip1" "Mmus\Rasip1, Mmus\Afdn, Mmus\Radil" "Hsap\RASIP1, Hsap\AFDN, Hsap\RADIL" " embryonic stage -- adult stage , embryonic stage | stage 5 , embryonic stage | stage 10 , embryonic stage | stage 13 , embryonic stage | stage 7-10 , embryonic stage , larval stage " " organism | restricted

,

ubiquitous , ectoderm

, embryonic/larval proventriculus

, posterior embryonic/larval midgut

, epidermis

, organism | striped

, eye-antennal disc

" FBgn0030608 Lsd-2 Lipid storage droplet-2 http://flybase.org/reports/FBgn0030608 protein_coding_gene protein binding ; GO:0005515 | inferred from physical interaction with klar regulation of transport ; GO:0051049 | inferred from mutant phenotype lipid storage ; GO:0019915 | inferred from expression pattern inferred from mutant phenotype lipid metabolic process ; GO:0006629 | inferred from mutant phenotype lipid transport ; GO:0006869 | inferred from expression pattern lipid particle transport along microtubule ; GO:0031887 | inferred from mutant phenotype negative regulation of lipid catabolic process ; GO:0050995 | inferred from mutant phenotype imaginal disc-derived wing morphogenesis ; GO:0007476 | inferred from mutant phenotype sequestering of triglyceride ; GO:0030730 | inferred from mutant phenotype lipid storage ; GO:0019915 | inferred from expression pattern lipid particle ; GO:0005811 | inferred from direct assay microtubule associated complex ; GO:0005875 | inferred from direct assay "145098_at, LSD2, CG9057, Lsd2, LSD-2, Lsd-2, LSP-2, plin2, PLIN2, DmPLIN2" IPR004279:Perilipin CG9057 27-Aug-18 DroID_v2018_08 "Drer\plin2, Drer\zgc:77486, Drer\zgc:162150, Drer\si:rp71-61h23.4" - - "Xtro\plin1, Xtro\plin3" "Mmus\Plin2, Mmus\Plin3, Mmus\Plin1, Mmus\Plin4, Mmus\Plin5" "Hsap\PLIN2, Hsap\PLIN4, Hsap\PLIN3, Hsap\PLIN5, Hsap\PLIN1" " larval stage | third instar , embryonic stage | late , embryonic stage | stage 5 , embryonic stage | stage 13 , embryonic stage | stage 4 " " fat body

, fat body && midgut | anterior

, germline cell

, amnioserosa

, organism | ubiquitous " larval stage | third instar fat body

"viable,fertile,lethal - all die before end of embryonic stage,non-rescuable maternal effect,some die during embryonic stage,visible,partially lethal - majority die,some die during pupal stage" "lipid particle | embryonic stage | maternal effect,fat body,lipid particle,embryonic/larval fat body,nurse cell,lipid particle | embryonic stage,lipid droplet & larval oenocyteppl.PP,mesothoracic tergum" FBgn0000826 png pan gu http://flybase.org/reports/FBgn0000826 FBgn0024363 protein_coding_gene ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR000719 protein serine/threonine kinase activity ; GO:0004674 | inferred from direct assay protein serine/threonine kinase activity ; GO:0004674 | traceable author statement "regulation of mitotic cell cycle ; GO:0007346 | traceable author statement protein phosphorylation ; GO:0006468 | inferred from direct assay egg activation ; GO:0007343 | inferred from mutant phenotype positive regulation of mitotic cell cycle, embryonic ; GO:0045977 | inferred from mutant phenotype" serine/threonine protein kinase complex ; GO:1902554 | inferred from physical interaction with plu "Png, EG:8D8.5, PNG, CG11420, fs(1)M2, pan-gnu, png" "IPR000719:Protein kinase domain, IPR008271:Serine/threonine-protein kinase, active site, IPR011009:Protein kinase-like domain" CG11420 27-Aug-18 DroID_v2018_08 "Drer\si:dkey-192d15.2, Drer\nek11, Drer\map3k2, Drer\si:ch211-285c6.3, Drer\nek8, Drer\LOC107980443, Drer\si:ch211-217i17.1, Drer\nek12, Drer\nek1, Drer\nek4, Drer\LOC101885992, Drer\si:ch211-285c6.2, Drer\LOC100536894, Drer\map3k3" "Scer\PKH3, Scer\KIN3" "Cele\T07F12.4, Cele\Y106G6A.1" "Xtro\nek5, Xtro\nek3, Xtro\nek9, Xtro\nek8, Xtro\nek4, Xtro\map3k2, Xtro\stkld1, Xtro\nek1, Xtro\map3k3, Xtro\nek10" "Mmus\Nek1, Mmus\Nek3, Mmus\Nek10, Mmus\Nek4, Mmus\Nek8, Mmus\Nek11, Mmus\Nek5, Mmus\Nek9, Mmus\Stkld1" "Hsap\NEK5, Hsap\NEK8, Hsap\NEK3, Hsap\NEK9, Hsap\NEK11, Hsap\NEK4, Hsap\NEK1, Hsap\STKLD1, Hsap\NEK10" " embryonic stage | 0-3 hr , adult stage | female " " egg stage | unfertilized egg , embryonic stage | 0-12 hr " unfertilized egg

"lethal,maternal effect,female sterile,viable,fertile,wild-type,mitotic cell cycle defective,meiotic cell cycle defective" "nuclear chromosome,nucleus,polar body nucleus,nucleus | embryonic stage,nucleus & unfertilized egg,nucleus | blastoderm stage | maternal effect,egg & nucleus,pronucleus,annulate lamellae" FBgn0261988 Gprk2 G protein-coupled receptor kinase 2 http://flybase.org/reports/FBgn0261988 protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR000239, InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290, InterPro:IPR017441 protein serine/threonine kinase activity ; GO:0004674 | non-traceable author statement G-protein coupled receptor kinase activity ; GO:0004703 | inferred from mutant phenotype G-protein coupled receptor kinase activity ; GO:0004703 | inferred from sequence or structural similarity" signal transduction ; GO:0007165 | inferred from sequence or structural similarity protein phosphorylation ; GO:0006468 | inferred from mutant phenotype regulation of Toll signaling pathway ; GO:0008592 | inferred from genetic interaction with Tl imaginal disc-derived wing vein specification ; GO:0007474 | inferred from mutant phenotype negative regulation of smoothened signaling pathway ; GO:0045879 | inferred from genetic interaction with fu inferred from genetic interaction with smo inferred from genetic interaction with ptc inferred from genetic interaction with Su(fu) protein phosphorylation ; GO:0006468 | inferred from sequence or structural similarity smoothened signaling pathway ; GO:0007224 | inferred from mutant phenotype apical constriction involved in gastrulation ; GO:0003384 | inferred from mutant phenotype regulation of smoothened signaling pathway ; GO:0008589 | inferred from direct assay protein phosphorylation ; GO:0006468 | non-traceable author statement positive regulation of cAMP-mediated signaling ; GO:0043950 | inferred from genetic interaction with Gαi inferred from genetic interaction with Gαs defense response to Gram-positive bacterium ; GO:0050830 | inferred from mutant phenotype regulation of antimicrobial peptide biosynthetic process ; GO:0002805 | inferred from mutant phenotype oocyte morphogenesis ; GO:0048601 | inferred from mutant phenotype plasma membrane ; GO:0005886 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay "gprk2, Gprk2, 154978_at, CG17998, Gprk-2, nosh" "IPR000239:GPCR kinase, IPR000719:Protein kinase domain, IPR000961:AGC-kinase, C-terminal, IPR011009:Protein kinase-like domain, IPR016137:RGS domain, IPR017441:Protein kinase, ATP binding site" CG17998 27-Aug-18 DroID_v2018_08 "Drer\grk4, Drer\grk6, Drer\grk1a, Drer\grk1b, Drer\grk7b, Drer\adrbk2, Drer\grk5, Drer\grk5l, Drer\grk7a" - Cele\grk-1 "Xtro\grk5, Xtro\grk7, Xtro\grk1, Xtro\grk4, Xtro\grk6" "Mmus\Grk6, Mmus\Grk4, Mmus\Grk3, Mmus\Grk1, Mmus\Grk2, Mmus\Grk5" "Hsap\GRK4, Hsap\GRK7, Hsap\GRK3, Hsap\GRK2, Hsap\GRK6, Hsap\GRK1, Hsap\GRK5" " larval stage | third instar , oogenesis stage && adult stage | female , embryonic stage | early , embryonic stage " ovary

" oogenesis stage && adult stage | female , larval stage , adult stage , adult stage && oogenesis stage , embryonic stage -- adult stage , larval stage && adult stage " " oocyte

, dorsal mesothoracic disc

, Kenyon cell

, longitudinal connective

, adult head

, larval central nervous system

, larval corpus allatum

, adult central nervous system

,

ubiquitous , optic lobe

, germarium

, follicle cell

, mushroom body

, retina

, mushroom body | restricted

, ovary

, neuron

, mushroom body alpha-lobe

, nurse cell

, ellipsoid body

" DRSC16682 I -1.711341334 -0.622063111 -0.283934963 -0.032537066 0.304681386 0.75792917 FBgn0004893 bowl brother of odd with entrails limited http://flybase.org/reports/FBgn0004893 "FBgn0022034, FBgn0014041" protein_coding_gene "nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR013087 RNA polymerase II transcription factor activity, sequence-specific DNA binding ; GO:0000981 | inferred from sequence or structural similarity with odd" "embryonic hindgut morphogenesis ; GO:0048619 | inferred from mutant phenotype embryonic pattern specification ; GO:0009880 | inferred from mutant phenotype lateral inhibition ; GO:0046331 | inferred from mutant phenotype positive regulation of transcription, DNA-templated ; GO:0045893 | inferred from sequence or structural similarity with UniProtKB:P23803 regulation of glucose metabolic process ; GO:0010906 | inferred from mutant phenotype imaginal disc-derived leg morphogenesis ; GO:0007480 | inferred from mutant phenotype embryonic foregut morphogenesis ; GO:0048617 | inferred from mutant phenotype hindgut morphogenesis ; GO:0007442 | inferred from mutant phenotype positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 | inferred from sequence or structural similarity with UniProtKB:P23803 wing disc development ; GO:0035220 | inferred from mutant phenotype negative regulation of transcription, DNA-templated ; GO:0045892 | inferred from sequence or structural similarity with UniProtKB:P23803 terminal region determination ; GO:0007362 | inferred from mutant phenotype negative regulation of transcription from RNA polymerase II promoter ; GO:0000122 | inferred from sequence or structural similarity with UniProtKB:P23803 imaginal disc-derived leg joint morphogenesis ; GO:0016348 | inferred from mutant phenotype" nucleus ; GO:0005634 | inferred from sequence or structural similarity with odd "Bowl, 17-29-5, Su(tor)2-1, l(2)c, org2, CG10021, bowl, BOWL" IPR013087:Zinc finger C2H2-type CG10021 27-Aug-18 DroID_v2018_08 "Drer\klf11a, Drer\klf15, Drer\osr1, Drer\znf148, Drer\egr2b, Drer\znf281b, Drer\egr4, Drer\osr2, Drer\sp2, Drer\si:ch211-117k10.3, Drer\egr1, Drer\znf281a" "Scer\MSN4, Scer\MSN2, Scer\FZF1" "Cele\egrh-3, Cele\odd-1, Cele\egrh-1, Cele\odd-2" "Xtro\egr1, Xtro\egr3, Xtro\klf11, Xtro\sp2, Xtro\klf15, Xtro\egr2, Xtro\osr1, Xtro\osr2" "Mmus\Sp2, Mmus\Egr4, Mmus\Egr3, Mmus\Osr1, Mmus\Osr2, Mmus\Klf11, Mmus\Egr1, Mmus\Klf15" "Hsap\EGR2, Hsap\KLF11, Hsap\EGR4, Hsap\ZBTB4, Hsap\KLF15, Hsap\EGR1, Hsap\OSR2, Hsap\OSR1, Hsap\ZBTB38, Hsap\ZBTB2, Hsap\EGR3, Hsap\SP2" " embryonic stage | stage 5 , embryonic stage , embryonic stage | stage 8-12 , embryonic stage | stage 7-9 , larval stage | third instar , embryonic stage | stage 11 , embryonic stage | stage 8-11 , pupal stage , embryonic stage | stage 7 , embryonic stage | stage 7-12 , embryonic stage | >= 2 hr , embryonic stage | stage 9 , embryonic stage | stage 11-14 " " organism | 80-100% egg length

, organism | pair rule

, posterior embryonic/larval midgut

,

0-10% egg length , amnioproctodeal invagination

, organism | 0-10% egg length

, ventral thoracic disc | restricted

, cephalic furrow

, labral segment

, organism | 80% egg length & ventral

, cephalic furrow | anterior to

, stomodeum

, organism | 70% egg length & dorsal

, embryonic/larval hindgut

,

terminal , leg | restricted

,

segment polarity , anterior embryonic/larval midgut

, embryonic/larval foregut

, organism | 20-100% egg length

" "lethal,recessive,visible,lethal - all die before end of embryonic stage,some die during embryonic stage,female sterile,semidominant,maternal effect,somatic clone,viable" "embryonic mandibular segment,embryonic maxillary segment,embryonic/larval hindgut,embryonic/larval proventriculus,joint,tarsal segment,embryonic large intestine,embryonic small intestine,embryonic rectum,lateral process,cephalopharyngeal skeleton,somatic clone,tarsal segment 2,tarsal segment 3,tarsal segment 4,metatarsus,pretarsus,abdominal 2 ventral denticle belt,abdominal 6 ventral denticle belt,embryonic hindgut,adult cuticle & leg | somatic clone,eye disc,peripodial epithelium & dorsal mesothoracic disc | somatic clone | first instar larval stage,eye-antennal disc,antenna,ectopic,eye,prescutum,embryonic dorsal epidermis,embryonic proventriculus,keyhole structure,sex comb,thorax,chaeta,supernumerary" DRSC00805 E 0.132752495 -0.020690858 0.10548997 -1.875326317 0.192595915 0.752246115 FBgn0028381 Decay Death executioner caspase related to Apopain/Yama http://flybase.org/reports/FBgn0028381 protein_coding_gene cysteine-type endopeptidase activity ; GO:0004197 | traceable author statement cysteine-type endopeptidase activity ; GO:0004197 | inferred from sequence or structural similarity with Dcp-1 inferred from direct assay cysteine-type endopeptidase activity involved in apoptotic process ; GO:0097153 | inferred from biological aspect of ancestor with PANTHER:PTN000047947 "proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR001309, InterPro:IPR002138, InterPro:IPR011600, InterPro:IPR016129 larval midgut histolysis ; GO:0035069 | NOT inferred from mutant phenotype apoptotic process ; GO:0006915 | inferred from mutant phenotype programmed cell death ; GO:0012501 | traceable author statement" cytoplasm ; GO:0005737 | inferred from direct assay "caspase 3, Caspase-3, caspase-3, Decay, CG14902, Drosophila executioner caspase related to Apopain/Yama, DECAY, Casp3, cas3, decay, Cas3, CC3, CAS3, CC-3" "IPR001309:Peptidase C14, p20 domain, IPR002138:Peptidase C14, caspase non-catalytic subunit p10, IPR015917:Peptidase C14A, caspase catalytic domain, IPR016129:Peptidase family C14A, His active site, IPR029030:Caspase-like domain, IPR033139:Peptidase family C14A, cysteine active site, IPR033176:Caspase DECAY" CG14902 27-Aug-18 DroID_v2018_08 "Drer\zgc:171731, Drer\si:dkey-103e21.5, Drer\casp9, Drer\pea15, Drer\LOC101886133, Drer\casp6l1, Drer\casp6, Drer\LOC100331324, Drer\si:ch211-195h23.3, Drer\caspbl, Drer\LOC798445, Drer\casp8l2, Drer\casp8, Drer\casp6l2, Drer\cflara, Drer\casp3b, Drer\casp7, Drer\gbp3, Drer\caspxa, Drer\zgc:194469, Drer\casp2, Drer\caspa, Drer\casp3a, Drer\caspb, Drer\casp8l1" - "Cele\ced-3, Cele\csp-1" "Xtro\pea15, Xtro\casp7, Xtro\casp1, Xtro\casp3, Xtro\casp10, Xtro\casp2, Xtro\casp6, Xtro\casp9, Xtro\LOC733553" "Mmus\Casp7, Mmus\Casp8, Mmus\Casp1, Mmus\Casp6, Mmus\Casp4, Mmus\Casp12, Mmus\Casp3, Mmus\Pycard, Mmus\Casp14, Mmus\Pea15a, Mmus\Casp9, Mmus\Casp2, Mmus\Cflar" "Hsap\CASP7, Hsap\CASP10, Hsap\CASP14, Hsap\CASP4, Hsap\CASP8, Hsap\CARD16, Hsap\CASP2, Hsap\CASP6, Hsap\CARD17, Hsap\CARD8, Hsap\CFLAR, Hsap\PYCARD, Hsap\CASP5, Hsap\PEA15, Hsap\CASP1, Hsap\CASP9, Hsap\CASP3, Hsap\CARD18" " embryonic stage | stage >=13 , larval stage | third instar , embryonic stage | stage 1-7 , adult stage && oogenesis stage , embryonic stage -- adult stage " " embryonic/larval midgut

,

ubiquitous , oocyte

, nurse cell

, eye disc

, larval brain

, egg chamber

, embryonic/larval salivary gland

" "viable,fertile,visible,male semi-sterile" "trichogen cell,male accessory gland,ejaculatory duct,seminal vesicle" DRSC16930 EK -0.227542395 -0.01868415 1.045984036 1.566359268 -0.759995687 1.895748115 FBgn0004369 Ptp99A Protein tyrosine phosphatase 99A http://flybase.org/reports/FBgn0004369 "FBan0002005, FBan0011517, FBgn0010251, FBgn0039661, FBgn0039662, FBgn0040621, FBgn0040622" protein_coding_gene protein tyrosine phosphatase activity ; GO:0004725 | non-traceable author statement protein tyrosine phosphatase activity ; GO:0004725 | inferred from sequence or structural similarity with protein_id:CAA38067.1 transmembrane receptor protein tyrosine phosphatase activity ; GO:0005001 | inferred from sequence or structural similarity protein tyrosine phosphatase activity ; GO:0004725 | inferred from sequence or structural similarity with HGNC:9671 "motor neuron axon guidance ; GO:0008045 | inferred from genetic interaction with Lar, Ptp10D motor neuron axon guidance ; GO:0008045 | inferred from genetic interaction with Ptp69D protein dephosphorylation ; GO:0006470 | inferred from sequence or structural similarity with protein_id:CAA38067.1 protein dephosphorylation ; GO:0006470 | non-traceable author statement axonal defasciculation ; GO:0007414 | traceable author statement defasciculation of motor neuron axon ; GO:0007415 | inferred from genetic interaction with Ptp69D regulation of glucose metabolic process ; GO:0010906 | inferred from mutant phenotype" plasma membrane ; GO:0005886 | inferred from sequence or structural similarity plasma membrane ; GO:0005886 | inferred from direct assay axon ; GO:0030424 | inferred from direct assay "DPTP99A, CT6383, R-PTP 99A, CG11516, CG2005, PTP99A, dptp99A, DPTP[[99A]], CG11515, CG11517, Ptp99A, ptp99A" "IPR000242:PTP type protein phosphatase, IPR000387:Tyrosine specific protein phosphatases domain, IPR003961:Fibronectin type III, IPR016130:Protein-tyrosine phosphatase, active site, IPR003595:Protein-tyrosine phosphatase, catalytic, IPR015943:WD40/YVTN repeat-like-containing domain, IPR029021:Protein-tyrosine phosphatase-like, IPR013783:Immunoglobulin-like fold, IPR007110:Immunoglobulin-like domain" CG11516 27-Aug-18 DroID_v2018_08 "Drer\ptprga, Drer\ptprd, Drer\ptprfa, Drer\ptpn5, Drer\ptpn2b, Drer\ca16c, Drer\ptpn18, Drer\ptprz1b, Drer\ca16b, Drer\ptprr, Drer\ptpn2a, Drer\ptprfb, Drer\ptpn22, Drer\ptprsa, Drer\ptpn1" "Scer\PTP2, Scer\PTP1, Scer\PTP3" "Cele\K07F5.8, Cele\F20H11.4, Cele\C17H12.3, Cele\F10G8.1, Cele\F25H5.7, Cele\T27A3.5, Cele\C55B7.3, Cele\C33H5.16, Cele\C02B10.6, Cele\F38H4.4, Cele\T28F4.3, Cele\ZK616.65, Cele\F47B3.6, Cele\F36H12.10, Cele\egg-3, Cele\C33F10.8, Cele\M04G7.2, Cele\Y48G9A.9, Cele\C46A5.1, Cele\ZK354.8, Cele\Y71F9AL.4, Cele\ptp-4, Cele\F55F8.7, Cele\T22C1.8, Cele\F55H12.5, Cele\F20B6.1, Cele\ptp-3, Cele\ZK484.7, Cele\F36H1.3, Cele\Y39A3A.4, Cele\R10F2.6, Cele\B0207.1, Cele\F47B3.1" "Xtro\ptpn12, Xtro\ptpn22, Xtro\ptpn1, Xtro\ptpn2, Xtro\ptprr, Xtro\ptprz1, Xtro\ptprd, Xtro\ptpn23, Xtro\ptprf, Xtro\ptprs" "Mmus\Ptpn2, Mmus\Ptpn18, Mmus\Ptpn22, Mmus\Ptprc, Mmus\Ptprs, Mmus\Ptprr, Mmus\Ptpn7, Mmus\Ptpn12, Mmus\Ptprd, Mmus\Ptpn20, Mmus\Ptprz1, Mmus\Ptpn5, Mmus\Ptpn23, Mmus\Ptpn1, Mmus\Ptprg, Mmus\Ptprf" "Hsap\PTPN7, Hsap\PTPRD, Hsap\PTPN2, Hsap\PTPN23, Hsap\PTPRF, Hsap\PTPN20, Hsap\PTPN22, Hsap\PTPRR, Hsap\PTPRC, Hsap\PTPN18, Hsap\PTPN1, Hsap\PTPN5, Hsap\PTPN12, Hsap\PTPRG, Hsap\PTPRZ1, Hsap\PTPRS" " larval stage | first instar , embryonic stage | stage 12-14 , embryonic stage , embryonic stage | stage 12 , adult stage , embryonic stage && adult stage , embryonic stage&&adult stage , embryonic stage | stage >=13 , embryonic stage | early , larval stage " " RP1 neuron

, aCC neuron

, central nervous system | restricted

, adult head

, RP2 neuron

, pCC neuron

, VUM neuron

, embryonic central nervous system | segmentally repeated pattern

, imaginal disc

, RP3 neuron

" " embryonic stage | stage 12-16 , embryonic stage | stage 12-17 , embryonic stage | stage >=13 , embryonic stage | stage 12-14 , embryonic stage | stage >=12 , embryonic stage | stage 12 , embryonic stage , embryonic stage | stage 13-17 " " segmental nerve

, longitudinal connective

, intersegmental nerve

, embryonic central nervous system

, posterior commissure

, aCC neuron

, anterior commissure

, commissure

, RP2 neuron

, RP1 neuron

, supraesophageal ganglion

, pCC neuron

, RP3 neuron

, embryonic/larval trachea

, neuron

, ventral nerve cord

, central nervous system | restricted

" "viable,fertile,chemical sensitive" "intersegmental nerve,abdominal segmental nerve" DRSC14319 K 1.916851367 -0.487310118 FBgn0014143 croc crocodile http://flybase.org/reports/FBgn0014143 FBgn0004894 protein_coding_gene "sequence-specific DNA binding ; GO:0043565 | inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122 DNA binding ; GO:0003677 | inferred from direct assay RNA polymerase II transcription factor activity, sequence-specific DNA binding ; GO:0000981 | inferred from biological aspect of ancestor with PANTHER:PTN001371846" "regulation of transcription, DNA-templated ; GO:0006355 | inferred from electronic annotation with InterPro:IPR001766, InterPro:IPR018122, InterPro:IPR030456 specification of segmental identity, head ; GO:0007380 | inferred from mutant phenotype" nucleus ; GO:0005634 | inferred from direct assay "Dmfd1, FD1, fd78E, fd1, CG5069, croc, FoxC" "IPR001766:Fork head domain, IPR011991:Winged helix-turn-helix DNA-binding domain, IPR018122:Fork head domain conserved site1, IPR030456:Fork head domain conserved site 2" CG5069 27-Aug-18 DroID_v2018_08 "Drer\foxl1, Drer\foxc1a, Drer\foxd1, Drer\foxa1, Drer\foxa2, Drer\foxe1, Drer\foxd2, Drer\foxd3, Drer\zgc:162612, Drer\foxa, Drer\foxa3, Drer\foxc1b, Drer\foxd5, Drer\foxe3" "Scer\HCM1, Scer\FKH1" "Cele\unc-130, Cele\pha-4, Cele\fkh-6, Cele\fkh-2" "Xtro\foxd4l1.1, Xtro\foxd1, Xtro\foxc2, Xtro\foxc1, Xtro\foxi4.2, Xtro\foxe1, Xtro\foxa1, Xtro\foxa2, Xtro\foxd3, Xtro\foxl1, Xtro\foxe3, Xtro\foxa4, Xtro\foxd2" "Mmus\Foxd4, Mmus\Foxd3, Mmus\Foxe1, Mmus\Foxa2, Mmus\Foxl1, Mmus\Foxa3, Mmus\Foxc2, Mmus\Foxd1, Mmus\Foxa1, Mmus\Foxs1, Mmus\Foxc1, Mmus\Foxd2" "Hsap\FOXA1, Hsap\FOXD4L6, Hsap\FOXI3, Hsap\FOXD4L1, Hsap\FOXD4L5, Hsap\FOXE1, Hsap\FOXS1, Hsap\FOXD1, Hsap\FOXD4, Hsap\FOXA2, Hsap\FOXC1, Hsap\FOXD3, Hsap\FOXC2, Hsap\FOXD4L3, Hsap\FOXD4L4, Hsap\FOXL1, Hsap\FOXA3, Hsap\FOXD2" " embryonic stage | blastoderm , embryonic stage | stage 11 , embryonic stage | stage 17 , embryonic stage | stage 7 , embryonic stage | stage 9 , embryonic stage , embryonic stage | stage 7-13 , embryonic stage | stage 5 , embryonic stage | stage 5,6 " " stomodeum

, embryonic/larval pharynx | posterior

, intercalary segment

, mesoderm | posterior | restricted

, embryonic central nervous system

, embryonic/larval foregut

, labral segment

,

posterior | restricted , mesoderm | segmentally repeated

,

anterior | restricted " " embryonic stage | stage 5,6 , embryonic stage | stage 11 , embryonic stage | stage 9 , embryonic stage | stage 17 , embryonic stage | stage 7 , embryonic stage | stage 5 , embryonic stage | stage 7-13 " "

anterior | restricted , mesoderm | segmentally repeated

, mesoderm | posterior | restricted

, embryonic/larval pharynx | posterior

, stomodeum

, labral segment

, intercalary segment

,

posterior | restricted , embryonic/larval foregut

" "lethal - all die before end of embryonic stage,recessive,some die during embryonic stage,viable,visible" "embryonic labral segment,embryonic antennal segment,embryonic intercalary segment,embryonic/larval esophagus,stomatogastric nervous system,embryonic/larval labral nerve,adult labral sense organ,dorsopharyngeal organ,pharyngeal monoscolopidial chordotonal organ,trichogen cell" FBgn0028554 x16 x16 splicing factor http://flybase.org/reports/FBgn0028554 protein_coding_gene zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR001878 mRNA binding ; GO:0003729 | inferred from direct assay RNA binding ; GO:0003723 | inferred from sequence model protein binding ; GO:0005515 | inferred from physical interaction with Trn-SR mRNA binding ; GO:0003729 | inferred from sequence or structural similarity "regulation of alternative mRNA splicing, via spliceosome ; GO:0000381 | inferred from mutant phenotype mRNA splicing, via spliceosome ; GO:0000398 | inferred from sequence or structural similarity with HGNC:10785 mRNA splicing, via spliceosome ; GO:0000398 | inferred by curator from GO:0071011,GO:0071013 regulation of gene expression ; GO:0010468 | inferred from mutant phenotype RNA splicing ; GO:0008380 | inferred from physical interaction with CG7564, Rbp1, Doa regulation of transcriptional start site selection at RNA polymerase II promoter ; GO:0001178 | inferred from mutant phenotype regulation of mRNA 3'-end processing ; GO:0031440 | inferred from mutant phenotype" precatalytic spliceosome ; GO:0071011 | inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay catalytic step 2 spliceosome ; GO:0071013 | inferred from direct assay "9G8, TN166, d9G8, Dxl6, CG10203, X16/9G8, Xl6, RBP1-like, l(2)k00230, 2/30, anon-WO0118547.78, dxl6, xl6, x16, XL6, dx16, Dx16, X16" "IPR000504:RNA recognition motif domain, IPR001878:Zinc finger, CCHC-type" CG10203 27-Aug-18 DroID_v2018_08 "Drer\srsf3b, Drer\srsf7a, Drer\srsf7b, Drer\srsf3a" "Scer\NAB3, Scer\NPL3" "Cele\rsp-6, Cele\Y57G11A.5" "Xtro\srsf3, Xtro\srsf7" "Mmus\Srsf7, Mmus\Srsf3" "Hsap\SRSF3, Hsap\HNRNPC, Hsap\SRSF7" " embryonic stage | stage 11 , embryonic stage | stage 5-11 , larval stage | third instar , embryonic stage | stage 14-16 , adult stage && oogenesis stage " " ventral neurogenic region

,

ubiquitous , eye-antennal disc | restricted

, ventral thoracic disc | restricted

, embryonic brain

, dorsal mesothoracic disc | restricted

, nurse cell

, embryonic central nervous system

" "visible,lethal,recessive,viable,fertile" "eye,trichogen cell" FBgn0025525 bab2 bric a brac 2 http://flybase.org/reports/FBgn0025525 "FBgn0012044, FBgn0035185" protein_coding_gene "AT DNA binding ; GO:0003680 | inferred from direct assay transcription factor activity, sequence-specific DNA binding ; GO:0003700 | traceable author statement protein binding ; GO:0005515 | inferred from physical interaction with bip2" "regulation of stem cell differentiation ; GO:2000736 | inferred from mutant phenotype female gonad morphogenesis ; GO:0061040 | inferred from mutant phenotype transcription, DNA-templated ; GO:0006351 | traceable author statement regulation of transcription, DNA-templated ; GO:0006355 | traceable author statement regulation of transcription from RNA polymerase II promoter ; GO:0006357 | inferred from biological aspect of ancestor with PANTHER:PTN001135004 leg disc morphogenesis ; GO:0007478 | inferred from expression pattern eye-antennal disc morphogenesis ; GO:0007455 | inferred from expression pattern" nucleus ; GO:0005634 | inferred from direct assay nucleus ; GO:0005634 | traceable author statement polytene chromosome chromocenter ; GO:0005701 | NOT inferred from direct assay polytene chromosome ; GO:0005700 | inferred from direct assay "bab, bab-II, BAB2, BTB-II, CG13911, CG9102, BtbII, bab2, Bab2, BAB" "IPR000210:BTB/POZ domain, IPR007889:DNA binding HTH domain, Psq-type, IPR011333:SKP1/BTB/POZ domain, IPR009057:Homeobox domain-like" CG9102 27-Aug-18 DroID_v2018_08 - - "Cele\sdz-28, Cele\btb-13" - "Mmus\Nacc2, Mmus\Nacc1" "Hsap\NACC2, Hsap\NACC1, Hsap\ZBTB12" " prepupal stage , larval stage | third instar " " ovary | restricted

, ventral thoracic disc | restricted

" " prepupal stage | stage P1 , prepupal stage , larval stage | third instar stage 2 , larval stage | third instar " " ovary | restricted

, central nervous system | restricted

, larval central nervous system | restricted

, ventral thoracic disc | restricted

, female genital disc | restricted

, male genital disc | restricted

" "visible,dominant,male,body color defective,recessive,female,female sterile,female fertile,partially lethal - majority die,lethal,viable,cell number defective,cell migration defective" "adult cuticle & abdominal segment 5 | male,adult cuticle & abdominal segment 6 | male,leg,ovary,abdominal tergite 5,female,abdominal tergite 6,ovariole,antenna,prothoracic tarsal segment 2,tarsal segment 4,tarsal segment 5,abdominal tergite 7,terminal filament,adult abdominal segment 4,adult abdominal segment 5,adult abdominal segment 6,tergite,adult abdomen & cuticlep339,tarsal segment,wing,adult abdomen & cuticle30A,basal cylinder,arista,ectopic,haltere,wing hinge,wing disc,adult cuticle & abdominal segment | malepnr-MD237,abdominal sternite 6,male,abdominal sternite 7,abdominal sternite 6 & trichome | maleC-765,abdominal tergite 6 & trichome | maleC-765,abdominal sternite 6 & macrochaeta | maleC-765,abdominal tergite 6 & macrochaeta | maleC-765,mesothoracic tergum,terminal filament | prepupal stage,embryonic/larval dorsal vessel" FBgn0029082 hbs hibris http://flybase.org/reports/FBgn0029082 protein_coding_gene protein binding ; GO:0005515 | inferred from physical interaction with sns positive regulation of Notch signaling pathway ; GO:0045747 | inferred from mutant phenotype myoblast fusion ; GO:0007520 | inferred from genetic interaction with sns compound eye morphogenesis ; GO:0001745 | inferred from mutant phenotype homophilic cell adhesion via plasma membrane adhesion molecules ; GO:0007156 | inferred from genetic interaction with rst heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ; GO:0007157 | inferred from direct assay regulation of striated muscle tissue development ; GO:0016202 | inferred from mutant phenotype inferred from genetic interaction with sns myoblast fusion ; GO:0007520 | traceable author statement establishment of ommatidial planar polarity ; GO:0042067 | inferred from mutant phenotype regulation of striated muscle tissue development ; GO:0016202 | inferred from mutant phenotype compound eye photoreceptor cell differentiation ; GO:0001751 | inferred from mutant phenotype Notch receptor processing ; GO:0007220 | inferred from mutant phenotype positive regulation of endopeptidase activity ; GO:0010950 | inferred from mutant phenotype Malpighian tubule stellate cell differentiation ; GO:0061330 | inferred from expression pattern inferred from mutant phenotype apical plasma membrane ; GO:0016324 | inferred from direct assay endosome ; GO:0005768 | colocalizes_with inferred from direct assay cell-cell adherens junction ; GO:0005913 | inferred from direct assay gamma-secretase complex ; GO:0070765 | colocalizes_with inferred from physical interaction with Psn "Hbs, CT22841, icon, CG7449, hbs" "IPR003006:Immunoglobulin/major histocompatibility complex, conserved site, IPR003598:Immunoglobulin subtype 2, IPR003599:Immunoglobulin subtype, IPR003961:Fibronectin type III, IPR007110:Immunoglobulin-like domain, IPR013162:CD80-like, immunoglobulin C2-set, IPR013783:Immunoglobulin-like fold, IPR013098:Immunoglobulin I-set" CG7449 27-Aug-18 DroID_v2018_08 "Drer\mybpc2a, Drer\mybpc2b, Drer\nphs1, Drer\myom1a" - "Cele\him-4, Cele\syg-2" "Xtro\LOC100216153, Xtro\nphs1, Xtro\LOC100145501, Xtro\hepacam2" "Mmus\Igfn1, Mmus\Sirpb1a, Mmus\Mybpc1, Mmus\Sirpa, Mmus\Mybpc2, Mmus\Myom3, Mmus\Myom2, Mmus\Nphs1, Mmus\Mybpc3" "Hsap\CD33, Hsap\MYBPC2, Hsap\HMCN2, Hsap\MYBPC3, Hsap\IGFN1, Hsap\NPHS1, Hsap\MYBPC1, Hsap\MYOM2, Hsap\IGSF22, Hsap\SIRPG, Hsap\MYOM3, Hsap\PRODH2" embryonic stage | stage 15 embryonic Malpighian tubule | restricted

"visible,recessive,planar polarity defective,viable,fertile,cell adhesion defective,somatic clone,partially lethal - majority die,some die during pupal stage" "eye,cone cell,microchaeta & adult thorax,interommatidial bristle,supernumerary,somatic clone,photoreceptor cell R3,photoreceptor cell R7,ommatidium,wing margin,notal microchaeta,adult Malpighian tubule Type II cell,presumptive embryonic/larval muscle system,embryonic myoblast,midgut chamber 1,visceral muscle primordium,visceral mesoderm,somatic mesoderm,myoblast,distal,microchaeta & scutumda.G32,microchaeta & scutum-537.4,dorsal,microchaeta & scutumpnr-MD237,inter-ommatidial cell,inter-ommatidial precursor cell,primary pigment cell,septate junction | somatic clone,cell-cell junction | somatic clone,eye photoreceptor cell,inter-ommatidial precursor cell | pupal stage P6,interommatidial bristle | pupal stage P6,wing hair" FBgn0003862 trx trithorax http://flybase.org/reports/FBgn0003862 "FBgn0011040, FBgn0011340, FBgn0011443" protein_coding_gene "zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR001628, InterPro:IPR001841, InterPro:IPR001965, InterPro:IPR016569 sequence-specific DNA binding ; GO:0043565 | inferred from electronic annotation with InterPro:IPR001628 transcription factor activity, sequence-specific DNA binding ; GO:0003700 | inferred from electronic annotation with InterPro:IPR001628 histone acetyltransferase activity ; GO:0004402 | contributes_to inferred from direct assay histone methyltransferase activity (H3-K4 specific) ; GO:0042800 | traceable author statement histone methyltransferase activity (H3-K4 specific) ; GO:0042800 | inferred from direct assay protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q94545 zinc ion binding ; GO:0008270 | inferred from sequence model chromatin binding ; GO:0003682 | inferred from direct assay protein phosphatase 1 binding ; GO:0008157 | inferred from physical interaction with flw inferred from physical interaction with Pp1-13C inferred from physical interaction with Pp1α-96A inferred from physical interaction with Pp1-87B transcription regulatory region DNA binding ; GO:0044212 | inferred from direct assay protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q9VCH5 protein homodimerization activity ; GO:0042803 | inferred from direct assay" histone H3 acetylation ; GO:0043966 | inferred from mutant phenotype regulation of response to DNA damage stimulus ; GO:2001020 | inferred from genetic interaction with lok histone acetylation ; GO:0016573 | inferred from direct assay histone H3-K4 methylation ; GO:0051568 | inferred by curator from GO:0044665 histone H3-K4 methylation ; GO:0051568 | inferred from direct assay eye development ; GO:0001654 | inferred from mutant phenotype inferred from genetic interaction with UniProtKB:Q9VCH5 axon guidance ; GO:0007411 | inferred from mutant phenotype histone methylation ; GO:0016571 | traceable author statement haltere development ; GO:0007482 | inferred from genetic interaction with UniProtKB:Q9VCH5 positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 | inferred from mutant phenotype histone H3-K4 methylation ; GO:0051568 | inferred from mutant phenotype positive regulation of transcription elongation from RNA polymerase II promoter ; GO:0032968 | inferred from direct assay inferred from mutant phenotype germ cell migration ; GO:0008354 | inferred from mutant phenotype histone methylation ; GO:0016571 | inferred from direct assay germ cell migration ; GO:0008354 | traceable author statement microtubule associated complex ; GO:0005875 | inferred from direct assay polytene chromosome ; GO:0005700 | inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay transcription elongation factor complex ; GO:0008023 | inferred from physical interaction with Sbf MLL1/2 complex ; GO:0044665 | inferred from direct assay histone acetyltransferase complex ; GO:0000123 | inferred from direct assay histone methyltransferase complex ; GO:0035097 | inferred from direct assay "trx, TRX, Trx, CG8651, trx-g, l(3)j14A6, DMTRXIII, trxI and trxII, NR0A5, 4733, 4720, Rg-bx, l(3)s5452, l(3)j3A2, l(3)bx[v], R-bx, Trx-G, tqrx, Trx/MLL, TrX" "IPR001214:SET domain, IPR001628:Zinc finger, nuclear hormone receptor-type, IPR001965:Zinc finger, PHD-type, IPR003616:Post-SET domain, IPR003888:FY-rich, N-terminal, IPR003889:FY-rich, C-terminal, IPR001841:Zinc finger, RING-type, IPR011011:Zinc finger, FYVE/PHD-type, IPR016569:Methyltransferase, trithorax, IPR019787:Zinc finger, PHD-finger, IPR034732:Extended PHD (ePHD) domain, IPR001487:Bromodomain, IPR013083:Zinc finger, RING/FYVE/PHD-type" CG8651 27-Aug-18 DroID_v2018_08 "Drer\si:ch211-57f7.7, Drer\kmt2ba, Drer\kmt2bb, Drer\si:ch211-37e10.1, Drer\phf11, Drer\kmt2a, Drer\setbp1" Scer\SET1 "Cele\set-25, Cele\lin-59" "Xtro\kmt2a, Xtro\LOC733724, Xtro\kmt2b" "Mmus\Phf11c, Mmus\Phf11d, Mmus\Phf7, Mmus\Setbp1, Mmus\Gm6904, Mmus\Kmt2b, Mmus\Phf11b, Mmus\Phf11a, Mmus\Kmt2a" "Hsap\SETBP1, Hsap\KMT2B, Hsap\PHF7, Hsap\PHF11, Hsap\KMT2A" " embryonic stage | early , embryonic stage , embryonic stage && larval stage && pupal stage , larval stage | third instar , adult stage | female , embryonic stage | stage 7-9 , embryonic stage | 11-15 hr , adult stage | male , embryonic stage | stage 5 , embryonic stage | 2-4hr , embryonic stage | stage 4 , embryonic stage -- adult stage , pupal stage , embryonic stage | late , embryonic stage | stage 4-8 " " embryonic central nervous system

, dorsal mesothoracic disc | posterior

,

ubiquitous , head

, imaginal disc

, dorsal metathoracic disc | posterior

, mesoderm | presumptive

, mesoderm anlage

, supraesophageal ganglion

, eye-antennal disc

, ventral mesothoracic disc | posterior

,

pair rule , subesophageal ganglion

, antenno-maxillary complex

, ventral nerve cord

,

20-50% egg length , ventral nervous system

, labral segment

, organism | even pair rule

" " larval stage | third instar , embryonic stage , larval stage " " dorsal mesothoracic disc | posterior

, dorsal metathoracic disc | posterior

, embryonic/larval proventriculus

, embryonic/larval salivary gland

, eye-antennal disc

, embryonic/larval midgut

, embryonic/larval digestive system

, ventral mesothoracic disc | posterior

, Malpighian tubule

, embryonic central nervous system

, imaginal disc

, gastric caecum

, larval fat body | central & posterior

" "viable,fertile,lethal,recessive,partially lethal - majority die,visible,lethal - all die before end of larval stage,some die during larval stage,increased cell death,heat sensitive,wild-type,dominant,homeotic,lethal - all die before end of embryonic stage,some die during embryonic stage,non-suppressor of variegation,non-enhancer of variegation,enhancer of variegation,increased cell number,somatic clone,mitotic cell cycle defective,male,partially lethal - majority live,lethal - all die before end of pupal stage,some die during pupal stage,some die during immature adult stage" "adult thorax,wing disc | third instar larval stage,prothoracic tibia,sex comb,prothoracic segment,haltere,metathoracic segment,metathoracic tibia,abdominal tergite 5,male,abdominal tergite 6,abdominal tergite 7,wing,eye,head,labellum,lateral,photoreceptor cell,somatic clone,eye disc,abdominal segment 6,wing vein,ectopic,embryonic/first instar larval cuticle,embryonic/larval brain,embryonic/larval midgut,abdominal segment 5,adult abdominal segment 5,adult abdominal segment 6,adult abdominal segment 7,midgut constriction 1,midgut constriction 2,denticle belt,metathoracic laterotergite,abdominal tergite 2,abdominal tergite 3,antenna,maxillary palpus,adult head,arista,anterior,ventral,ocellar bristle,ocellus,postvertical bristle,pupal cuticle & abdomen,abdominal tergite 1,epiproct,adult,abdominal tergite 4,male genitalia,sternite,spiracle,abdominal segment,gonad,precursor,adult abdominal segment 4,epidermis,embryonic/larval tracheal system,mesothoracic tergum" FBgn0265434 zip zipper http://flybase.org/reports/FBgn0265434 protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR001609, InterPro:IPR004009 myosin light chain binding ; GO:0032027 | inferred from physical interaction with sqh inferred from physical interaction with Mlc-c motor activity ; GO:0003774 | inferred from sequence or structural similarity with SGD:S000001065 ATPase activity, coupled ; GO:0042623 | inferred from sequence or structural similarity" "mitotic cytokinesis ; GO:0000281 | inferred from mutant phenotype dorsal closure ; GO:0007391 | traceable author statement muscle attachment ; GO:0016203 | NOT inferred from genetic interaction with l(2)gl dorsal closure ; GO:0007391 | inferred from genetic interaction with cno, PDZ-GEF maintenance of protein location in cell ; GO:0032507 | inferred from mutant phenotype myosin II filament assembly ; GO:0031036 | inferred from direct assay establishment of neuroblast polarity ; GO:0045200 | traceable author statement dorsal closure ; GO:0007391 | inferred from mutant phenotype myofibril assembly ; GO:0030239 | inferred from mutant phenotype Malpighian tubule morphogenesis ; GO:0007443 | inferred from mutant phenotype anterior midgut development ; GO:0007496 | inferred from mutant phenotype protein oligomerization ; GO:0051259 | inferred from direct assay sarcomere organization ; GO:0045214 | inferred from mutant phenotype ovarian follicle cell migration ; GO:0007297 | traceable author statement dorsal closure, amnioserosa morphology change ; GO:0046664 | inferred from mutant phenotype cuticle pattern formation ; GO:0035017 | inferred from mutant phenotype wound healing ; GO:0042060 | inferred from mutant phenotype head involution ; GO:0008258 | inferred from mutant phenotype neurogenesis ; GO:0022008 | inferred from mutant phenotype left/right axis specification ; GO:0070986 | inferred from mutant phenotype regulation of cell cycle ; GO:0051726 | inferred from direct assay dorsal closure, spreading of leading edge cells ; GO:0007395 | inferred from mutant phenotype border follicle cell migration ; GO:0007298 | inferred from mutant phenotype imaginal disc-derived wing hair organization ; GO:0035317 | inferred from genetic interaction with dsh inferred from genetic interaction with fz muscle contraction ; GO:0006936 | inferred from mutant phenotype dorsal closure, leading edge cell differentiation ; GO:0046663 | inferred from mutant phenotype establishment of planar polarity ; GO:0001736 | non-traceable author statement cellular response to mechanical stimulus ; GO:0071260 | inferred from direct assay regulation of tube length, open tracheal system ; GO:0035159 | inferred from mutant phenotype spiracle morphogenesis, open tracheal system ; GO:0035277 | inferred from direct assay regulation of myoblast fusion ; GO:1901739 | inferred from genetic interaction with kirre salivary gland morphogenesis ; GO:0007435 | inferred from mutant phenotype" cell-cell contact zone ; GO:0044291 | inferred from direct assay apical cortex ; GO:0045179 | colocalizes_with inferred from direct assay cell cortex ; GO:0005938 | inferred from direct assay cell cortex ; GO:0005938 | inferred from mutant phenotype apical cortex ; GO:0045179 | traceable author statement cell leading edge ; GO:0031252 | inferred from direct assay myosin II complex ; GO:0016460 | inferred from physical interaction with sqh inferred from physical interaction with Mlc-c cytosol ; GO:0005829 | inferred from direct assay contractile ring ; GO:0070938 | colocalizes_with inferred from direct assay cleavage furrow ; GO:0032154 | inferred from direct assay unconventional myosin complex ; GO:0016461 | inferred from sequence or structural similarity myosin complex ; GO:0016459 | inferred from sequence or structural similarity myosin II complex ; GO:0016460 | inferred from direct assay cytoskeleton ; GO:0005856 | non-traceable author statement Z disc ; GO:0030018 | inferred from direct assay unconventional myosin complex ; GO:0016461 | non-traceable author statement "zip, Zip, CG15792, MyoII, zipper, NMM, Myo-II, myoII, nmMHC, Dm nmII, DmnmII, Myo, nmy-2, E(br), DROMHC, l(2)02957, Dronm-MII, Mhc-c, zpr, anon-WO0140519.37, Mhc-c[1], Myo II, MHC, zip/MyoII, NMMII, Myo-II HC, Myo2, ZIP, l(2)17F1, myo II, Myo15, myosin-II" "IPR027417:P-loop containing nucleoside triphosphate hydrolase, IPR000048:IQ motif, EF-hand binding site, IPR001609:Myosin head, motor domain, IPR002928:Myosin tail, IPR004009:Myosin, N-terminal, SH3-like" CG15792 27-Aug-18 DroID_v2018_08 "Drer\myo5aa, Drer\myo18aa, Drer\LOC103909185, Drer\smyhc2, Drer\myh10, Drer\LOC100537963, Drer\LOC100329748, Drer\wu:fd14a01, Drer\myhb, Drer\myhz1.2, Drer\myh6, Drer\myo5c, Drer\myh11a, Drer\myo5b, Drer\myhz1.1, Drer\ns:zf-e68, Drer\smyhc3, Drer\LOC100333206, Drer\si:dkey-110c1.10, Drer\myhz2, Drer\myh7bb, Drer\LOC100329813, Drer\myh9a, Drer\smyhc1, Drer\myo18ab, Drer\myha, Drer\LOC100333572, Drer\LOC100331349, Drer\myh11b, Drer\vmhc, Drer\myhc4, Drer\myo5ab, Drer\vmhcl, Drer\myh7ba, Drer\myh14, Drer\myh9b" "Scer\MYO4, Scer\MYO1, Scer\MYO2" "Cele\hum-9, Cele\nmy-1, Cele\myo-5, Cele\syd-2, Cele\myo-3, Cele\unc-54, Cele\unc-15, Cele\nmy-2, Cele\myo-2, Cele\myo-6, Cele\myo-1, Cele\hum-2" "Xtro\myh9, Xtro\myo5b, Xtro\myh4, Xtro\myh6, Xtro\myo5a, Xtro\myo18b, Xtro\myh8, Xtro\LOC100493774, Xtro\myh13, Xtro\myh15, Xtro\myh2, Xtro\myh11" "Mmus\Myo18a, Mmus\Myh11, Mmus\Myh14, Mmus\Myh7, Mmus\Myo5b, Mmus\Myh6, Mmus\Myh13, Mmus\Myh7b, Mmus\Myh15, Mmus\Myh8, Mmus\Myh9, Mmus\Myh2, Mmus\Myh1, Mmus\Myh10, Mmus\Myh4, Mmus\Myo5c, Mmus\Myo18b, Mmus\Myh3, Mmus\Myo5a" "Hsap\MYH2, Hsap\MYO5A, Hsap\MYO18A, Hsap\MYH9, Hsap\MYH1, Hsap\MYH15, Hsap\MYH10, Hsap\MYO5C, Hsap\MYO18B, Hsap\MYH11, Hsap\MYH7, Hsap\MYH4, Hsap\MYH8, Hsap\MYH3, Hsap\MYO5B, Hsap\MYH6, Hsap\MYH7B, Hsap\MYH14, Hsap\MYH13" " embryonic stage , embryonic stage && adult stage , embryonic stage | stage 8 " " embryonic central nervous system

, mesoderm

" FBgn0020299 stumps stumps http://flybase.org/reports/FBgn0020299 "FBgn0024898, FBgn0025779, FBgn0028088, FBgn0038245, FBgn0051317, FBgn0063634" protein_coding_gene - "open tracheal system development ; GO:0007424 | non-traceable author statement mesodermal cell migration ; GO:0008078 | traceable author statement fibroblast growth factor receptor signaling pathway ; GO:0008543 | traceable author statement fibroblast growth factor receptor signaling pathway ; GO:0008543 | non-traceable author statement gastrulation ; GO:0007369 | non-traceable author statement epithelial cell migration, open tracheal system ; GO:0007427 | traceable author statement open tracheal system development ; GO:0007424 | inferred from mutant phenotype primary branching, open tracheal system ; GO:0007428 | traceable author statement oogenesis ; GO:0048477 | inferred from mutant phenotype mesoderm migration involved in gastrulation ; GO:0007509 | non-traceable author statement heart development ; GO:0007507 | non-traceable author statement mesoderm development ; GO:0007498 | inferred from expression pattern tracheal outgrowth, open tracheal system ; GO:0007426 | inferred from mutant phenotype morphogenesis of a branching structure ; GO:0001763 | non-traceable author statement glial cell development ; GO:0021782 | inferred from mutant phenotype" intracellular ; GO:0005622 | traceable author statement cytoplasm ; GO:0005737 | traceable author statement cytoplasm ; GO:0005737 | non-traceable author statement "stumps, Hbr, hbr, Dof, CG18485, dof, DOF, dof/hbr/sms, i21, i28, CG3375, Hbr/Dof, stumps/dof, Dof/stumps/heartbroken, dof/hbr, l(3)09904, heartbroken/dof, sms, gene C, P1740, 0837/10, C, l(3)S083710, anon-estC, anon-EST:CL47, CG31317, dof1" "IPR017893:DBB domain, IPR020683:Ankyrin repeat-containing domain" CG31317 27-Aug-18 DroID_v2018_08 Drer\pik3ap1 - - Xtro\pik3ap1 "Mmus\Bank1, Mmus\Pik3ap1" "Hsap\BANK1, Hsap\PIK3AP1" " embryonic stage | stage 11 , embryonic stage , embryonic stage | stage >=11 , embryonic stage | stage 9,10 , embryonic stage | stage >5 , embryonic stage | stage 13 , embryonic stage | stage 4 , embryonic stage | stage 5 , embryonic stage | syncytial blastoderm , embryonic stage | stage 11-12 " " tracheal pit

, embryonic/larval heart

, embryonic/larval tracheal system

, tracheal primordium

, mesoderm

, visceral mesoderm

, mesoderm anlage

, posterior midgut proper primordium

, anterior midgut proper primordium

,

ventral , embryonic glial cell

" " embryonic stage | stage 11 , larval stage | third instar , embryonic stage | stage <11 " " tracheal pit

, mesoderm

dorsal & restricted , dorsal mesothoracic disc && adepithelial cell

, mesoderm

" "lethal,recessive,female sterile,lethal - all die before end of embryonic stage,some die during embryonic stage,cell migration defective,somatic clone,viable" "embryonic/larval trachea,pericardial cell primordium,terminal tracheal cell,somatic clone,embryonic/larval tracheal system,presumptive embryonic salivary gland,tracheal system,embryonic/larval somatic muscle,dorsal,embryonic/larval pericardial cell,cardioblast,somatic mesoderm,visceral mesoderm,mesoderm,egg,presumptive embryonic/larval central nervous system,longitudinal connective,embryonic/larval dorsal vessel,midgut constriction 2,trachea,dorsal vessel primordium,embryonic pericardial cell,dorsal air sac primordium,embryonic/larval dorsal branch,glial cell,subretinal glial cell,somatic clone | third instar larval stage" DRSC15332 E 0.898952777 -1.395533715 0.51074249 -1.595115772 0.081020658 0.982072361 FBgn0004177 mts microtubule star http://flybase.org/reports/FBgn0004177 "FBgn0010514, FBgn0010703, FBgn0031953" protein_coding_gene protein serine/threonine phosphatase activity ; GO:0004722 | non-traceable author statement protein serine/threonine phosphatase activity ; GO:0004722 | inferred from mutant phenotype protein serine/threonine phosphatase activity ; GO:0004722 | inferred from sequence or structural similarity phosphatase regulator activity ; GO:0019208 | inferred from direct assay centrosome duplication ; GO:0051298 | inferred from mutant phenotype protein dephosphorylation ; GO:0006470 | non-traceable author statement oogenesis ; GO:0048477 | inferred from mutant phenotype chromosome segregation ; GO:0007059 | inferred from mutant phenotype negative regulation of neuroblast proliferation ; GO:0007406 | inferred from mutant phenotype microtubule cytoskeleton organization ; GO:0000226 | inferred from mutant phenotype response to light stimulus ; GO:0009416 | inferred from genetic interaction with inaC regulation of cell shape ; GO:0008360 | inferred from mutant phenotype centrosome cycle ; GO:0007098 | inferred from mutant phenotype protein dephosphorylation ; GO:0006470 | inferred from mutant phenotype positive regulation of smoothened signaling pathway ; GO:0045880 | inferred from genetic interaction with smo inferred from genetic interaction with hh actin filament organization ; GO:0007015 | inferred from mutant phenotype asymmetric neuroblast division ; GO:0055059 | inferred from genetic interaction with l(2)gl inferred from genetic interaction with par-6 spindle organization ; GO:0007051 | inferred from mutant phenotype autophagy ; GO:0006914 | inferred from mutant phenotype canonical Wnt signaling pathway ; GO:0060070 | inferred from mutant phenotype mitotic cell cycle ; GO:0000278 | inferred from mutant phenotype centriole replication ; GO:0007099 | inferred from mutant phenotype centrosome organization ; GO:0051297 | inferred from mutant phenotype establishment of epithelial cell polarity ; GO:0090162 | inferred from expression pattern regulation of glucose metabolic process ; GO:0010906 | inferred from mutant phenotype phagocytosis ; GO:0006909 | inferred from mutant phenotype spindle assembly ; GO:0051225 | inferred from mutant phenotype cell adhesion ; GO:0007155 | inferred from mutant phenotype mitotic nuclear division ; GO:0007067 | inferred from mutant phenotype R7 cell fate commitment ; GO:0007465 | inferred from genetic interaction with Ras85D centriole ; GO:0005814 | inferred from direct assay protein phosphatase type 2A complex ; GO:0000159 | inferred from sequence or structural similarity cytoplasm ; GO:0005737 | inferred from direct assay nucleoplasm ; GO:0005654 | inferred from direct assay "mts, CG7109, PP2A-C, PP2A, PP2A/MTS, PP2, DmPp2A-28D, PP2a, PP2Ac, PP2a 28D, PP2A[[C]], MTS/PP2A, dPP2A, 5559, PP2A 28D, Pp2A-28D, Pp2A, ER2-6, l(2)s5286, l(2)02496, Mts, PP2A C, PP2A[C], dPP2A-C, MTS" "IPR004843:Calcineurin-like phosphoesterase domain, ApaH type, IPR006186:Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase, IPR029052:Metallo-dependent phosphatase-like" CG7109 27-Aug-18 DroID_v2018_08 "Drer\ppp2cb, Drer\ppp4ca, Drer\ppp6c, Drer\ppp2ca, Drer\ppp4cb, Drer\zgc:56064" "Scer\PPH22, Scer\YNL217W, Scer\SIT4, Scer\PPG1, Scer\PPH21, Scer\PPH3" "Cele\pph-4.2, Cele\pph-4.1, Cele\pph-6, Cele\pph-1, Cele\let-92" "Xtro\ppp2cb, Xtro\ppp4c, Xtro\ppp2ca, Xtro\ppp6c" "Mmus\Ppp2ca, Mmus\Ppp6c, Mmus\Ppp4c, Mmus\Ppp2cb" "Hsap\PPP2CB, Hsap\PPP2CA, Hsap\PPP6C" " embryonic stage | early , embryonic stage | late , larval stage | third instar , adult stage && oogenesis stage , embryonic stage -- adult stage , embryonic stage && larval stage , embryonic stage , adult stage , embryonic stage | stage 9-11 , embryonic stage && larval stage && adult stage " " gonad

, embryonic/larval salivary gland

, imaginal disc

, supraesophageal ganglion

, nurse cell

,

ubiquitous , larval brain

, adult brain

, oocyte

, adult midgut

, neuroblast

, ventral nerve cord

" "visible,viable,fertile,lethal,recessive,lethal - all die before end of embryonic stage,some die during embryonic stage,mitotic cell cycle defective,neuroanatomy defective,planar polarity defective,locomotor rhythm defective,increased cell number,lethal - all die before end of pupal stage,some die during pupal stage,somatic clone" "eye,embryonic/larval hemocyte | third instar larval stage,neuroblast,supernumerary,embryonic/larval brain,wing hair,microtubule & neuromuscular junction | larval stageelav.PLu,bouton & neuromuscular junction | larval stageelav.PLu,embryonic/larval neuroblast,wing margin,type II neuroblast,somatic clone" DRSC03574 IE 0.918009972 -3.40249302 0.404905368 -3.907711575 1.051818802 -0.556150787 FBgn0015777 nrv2 nervana 2 http://flybase.org/reports/FBgn0015777 "FBgn0014867, FBgn0021885, FBgn0022206, FBgn0045319, FBgn0065838" protein_coding_gene sodium:potassium-exchanging ATPase activity ; GO:0005391 | contributes_to inferred from mutant phenotype cation transmembrane transporter activity ; GO:0008324 | contributes_to inferred from direct assay "potassium ion transport ; GO:0006813 | inferred from electronic annotation with InterPro:IPR000402 sodium ion transport ; GO:0006814 | inferred from electronic annotation with InterPro:IPR000402 cell adhesion involved in heart morphogenesis ; GO:0061343 | inferred from mutant phenotype establishment of glial blood-brain barrier ; GO:0060857 | inferred from mutant phenotype regulation of tube length, open tracheal system ; GO:0035159 | inferred from mutant phenotype cation transport ; GO:0006812 | inferred from direct assay regulation of tube diameter, open tracheal system ; GO:0035158 | inferred from mutant phenotype open tracheal system development ; GO:0007424 | inferred from mutant phenotype regulation of tube size, open tracheal system ; GO:0035151 | inferred from mutant phenotype septate junction assembly ; GO:0019991 | inferred from mutant phenotype sensory perception of sound ; GO:0007605 | inferred from mutant phenotype" sodium:potassium-exchanging ATPase complex ; GO:0005890 | inferred from electronic annotation with InterPro:IPR000402 septate junction ; GO:0005918 | inferred from direct assay plasma membrane ; GO:0005886 | inferred from direct assay plasma membrane ; GO:0005886 | inferred from sequence or structural similarity sodium:potassium-exchanging ATPase complex ; GO:0005890 | inferred by curator from GO:0005391 axon ; GO:0030424 | inferred from direct assay "Na[+]/K[+] ATPase, Nrv2, NaK ATPase, Na,K-ATPase, Na[+]/K[+]ATPase, Na[+]/K[+]-ATPase, 42kDa, l(2)k04223, l(2)k13315, l(2)SH0329, ecta, NEST:bs13c10, Nrv, CG9261, nrv2, l(2)SH2 0329, nrv2.2, Nrv2.2" IPR000402:Sodium/potassium-transporting ATPase subunit beta CG9261 27-Aug-18 DroID_v2018_08 "Drer\atp1b3a, Drer\atp1b2b, Drer\atp1b2a, Drer\atp1b1a, Drer\atp1b1b, Drer\atp1b3b, Drer\atp1b4" - "Cele\nkb-1, Cele\nkb-3, Cele\nkb-2" "Xtro\atp4b, Xtro\atp1b3, Xtro\atp1b4, Xtro\atp1b2, Xtro\atp1b1" "Mmus\Atp4b, Mmus\Atp1b4, Mmus\Atp1b1, Mmus\Atp1b3, Mmus\Atp1b2" "Hsap\ATP1B3, Hsap\ATP4B, Hsap\ATP1B2, Hsap\ATP1B4, Hsap\ATP1B1" adult stage "

, adult abdomen

, abdomen

, adult head

" " embryonic stage , adult stage , embryonic stage -- adult stage " " embryonic peripheral nervous system

, adult abdomen

, leg

, head

, longitudinal connective

, commissure

, central nervous system

, adult head

, adult brain

, embryonic/larval garland cell

, adult thorax

, embryonic/larval posterior spiracle

, thoracico-abdominal ganglion

, optic lobe

" "lethal,recessive,neuroanatomy defective,viable,visible,auditory perception defective" "septate junction,embryonic/larval dorsal trunk,embryonic/larval transverse connective,embryonic/larval tracheal system,embryonic ganglionic branch & embryonic tracheole,septate junction & embryonic tracheal system,ganglionic branch primordium,dorsal trunk primordium,presumptive embryonic salivary gland,embryonic somatic muscle,tracheal branch primordium,trichogen cell,Johnston organ" FBgn0000769 fs(1)A1059 female sterile (1) A1059 http://flybase.org/reports/FBgn0000769 - gene molecular_function ; GO:0003674 | no biological data available oogenesis ; GO:0048477 | traceable author statement cellular_component ; GO:0005575 | no biological data available "fs(1)M60, fs(1)1059, fs(1)K575[ts], fs(1)K575, fs(1)A1059" - - 27-Aug-18 DroID_v2018_08 - - - - - - "female sterile,heat sensitive" FBgn0053814 His2A:CG33814 His2A:CG33814 http://flybase.org/reports/FBgn0053814 protein_coding_gene protein heterodimerization activity ; GO:0046982 | inferred from electronic annotation with InterPro:IPR009072 DNA binding ; GO:0003677 | inferred from sequence or structural similarity with UniProtKB:Q7L7L0 chromatin organization ; GO:0006325 | inferred from sequence or structural similarity with MGD:Hist1h2aa; MGI:MGI:2448285 nuclear nucleosome ; GO:0000788 | inferred from sequence or structural similarity with UniProtKB:Q7L7L0 "CG33814, His2A:CG33814" "IPR009072:Histone-fold, IPR007125:Histone H2A/H2B/H3, IPR002119:Histone H2A, IPR032458:Histone H2A conserved site, IPR032454:Histone H2A, C-terminal domain" CG33814 27-Aug-18 DroID_v2018_08 "Drer\si:ch1073-159d7.11, Drer\si:ch73-368j24.13, Drer\h2afy2, Drer\zgc:101846, Drer\si:ch211-113a14.16, Drer\si:dkey-261m9.11, Drer\si:dkey-23a13.20, Drer\si:ch211-113a14.26, Drer\si:ch1073-159d7.10, Drer\si:ch73-368j24.14, Drer\si:dkey-261m9.18, Drer\h2afx, Drer\si:ch211-113a14.7, Drer\zgc:110434, Drer\si:dkey-261m9.7, Drer\si:dkey-23a13.14, Drer\LOC100334934, Drer\si:ch211-113a14.11, Drer\LOC100332229, Drer\si:dkey-261m9.15, Drer\LOC570115, Drer\si:dkey-108k21.26, Drer\si:ch211-113a14.19, Drer\si:dkey-108k21.15, Drer\zgc:173652, Drer\si:dkey-108k21.19, Drer\si:ch73-36p18.5, Drer\zgc:195633, Drer\zgc:154164, Drer\fbxl6, Drer\LOC100148591, Drer\si:dkey-23a13.7, Drer\zgc:114037" "Scer\HTA2, Scer\HTA1" "Cele\his-65, Cele\his-68, Cele\his-35, Cele\his-47, Cele\his-61, Cele\his-7, Cele\his-33, Cele\his-57, Cele\htas-1, Cele\his-21, Cele\his-30, Cele\his-16, Cele\his-3, Cele\his-19, Cele\his-53, Cele\his-43, Cele\his-51, Cele\his-12" "Xtro\hist1h2aa, Xtro\h2afx, Xtro\hist1h2am, Xtro\h2afj, Xtro\h2afy2, Xtro\hist1h2aj, Xtro\h2afy, Xtro\hist1h2ad, Xtro\hist1h2ah" "Mmus\Hist2h2aa2, Mmus\Hist2h2ab, Mmus\Hist3h2a, Mmus\Hist1h2ao, Mmus\H2afb1, Mmus\Hist2h2ac, Mmus\Hist2h2aa1, Mmus\H2al1n, Mmus\H2afy2, Mmus\Hist1h2ai, Mmus\H2afx, Mmus\H2afb2, Mmus\Gm14920, Mmus\H2al1j, Mmus\H2al2c, Mmus\Hist1h2ak, Mmus\H2al2b, Mmus\H2afj, Mmus\Hist1h2ae, Mmus\Hist1h2ab, Mmus\Hist1h2an, Mmus\Hist1h2ah, Mmus\Hist1h2ag, Mmus\Hist1h2af, Mmus\H2afy, Mmus\Hist2h3c1, Mmus\Hist1h2ad, Mmus\Hist1h2ap, Mmus\Hist1h2ac, Mmus\H2afb3, Mmus\Hist1h2aa" "Hsap\HIST1H2AE, Hsap\HIST2H2AB, Hsap\HIST1H2AK, Hsap\HIST2H2AA3, Hsap\HIST1H2AG, Hsap\HIST1H2AJ, Hsap\H2AFB2, Hsap\HIST1H2AA, Hsap\H2AFY, Hsap\H2AFY2, Hsap\H2AFJ, Hsap\HIST1H2AI, Hsap\HIST1H2AC, Hsap\H2AFB1, Hsap\HIST1H2AH, Hsap\HIST1H2AL, Hsap\HIST1H2AM, Hsap\HIST2H2AA4, Hsap\H2AFX, Hsap\HIST3H2A, Hsap\HIST1H2AB, Hsap\HIST2H2AC, Hsap\H2AFB3, Hsap\HIST1H2AD" FBgn0085259 CG34230 - http://flybase.org/reports/FBgn0085259 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG34230 - CG34230 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0039882 CG11576 - http://flybase.org/reports/FBgn0039882 protein_coding_gene riboflavin transporter activity ; GO:0032217 | inferred from electronic annotation with InterPro:IPR009357 riboflavin transport ; GO:0032218 | inferred from electronic annotation with InterPro:IPR009357 integral component of plasma membrane ; GO:0005887 | inferred from electronic annotation with InterPro:IPR009357 cytosol ; GO:0005829 | inferred from direct assay CG11576 "IPR009357:Solute carrier family 52, riboflavin transporter" CG11576 27-Aug-18 DroID_v2018_08 "Drer\zgc:91890, Drer\si:ch73-196l6.5, Drer\slc52a3, Drer\slc52a2" - "Cele\rft-2, Cele\rft-1" "Xtro\slc52a1, Xtro\slc52a3" "Mmus\Slc52a2, Mmus\Slc52a3" "Hsap\SLC52A3, Hsap\SLC52A2, Hsap\SLC52A1" "viable,fertile,lethal,partially lethal - majority die,some die during pupal stage" FBgn0067067 Nrt::Wnt2 Nrt::Wnt2 http://flybase.org/reports/FBgn0067067 engineered_fusion_gene - - - Nrt::Wnt2 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0003314 sam sperm amotile http://flybase.org/reports/FBgn0003314 - gene - - - sam - - 27-Aug-18 DroID_v2018_08 - - - - - - male sterile FBgn0060448 l(3)S121612 lethal (3) S121612 http://flybase.org/reports/FBgn0060448 gene - - - "1216/12, l(3)S121612" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0053905 His4:CG33905 His4:CG33905 http://flybase.org/reports/FBgn0053905 protein_coding_gene "protein heterodimerization activity ; GO:0046982 | inferred from electronic annotation with InterPro:IPR009072 histone binding ; GO:0042393 | inferred from sequence or structural similarity with UniProtKB:P62805 DNA binding ; GO:0003677 | inferred from electronic annotation with InterPro:IPR001951, InterPro:IPR019809" "DNA-templated transcription, initiation ; GO:0006352 | inferred from electronic annotation with InterPro:IPR004823 nucleosome assembly ; GO:0006334 | inferred from sequence or structural similarity with UniProtKB:P62805" "nucleus ; GO:0005634 | inferred from electronic annotation with InterPro:IPR001951, InterPro:IPR019809 nucleosome ; GO:0000786 | inferred from sequence or structural similarity with UniProtKB:P62805" "CG33905, His4:CG33905" "IPR019809:Histone H4, conserved site, IPR009072:Histone-fold, IPR001951:Histone H4, IPR004823:TATA box binding protein associated factor (TAF)" CG33905 27-Aug-18 DroID_v2018_08 "Drer\si:dkey-23a13.7, Drer\si:ch211-113a14.26, Drer\si:dkey-108k21.19, Drer\LOC100329358, Drer\si:ch73-36p18.3, Drer\zgc:153409, Drer\LOC794549, Drer\zgc:154164, Drer\si:ch73-368j24.1, Drer\LOC562770, Drer\si:dkey-108k21.28, Drer\si:dkey-261m9.17, Drer\LOC100150038, Drer\si:ch73-368j24.14, Drer\si:dkey-108k21.12, Drer\si:ch73-36p18.4, Drer\hist1h4l, Drer\LOC100331412, Drer\si:ch211-113a14.17, Drer\zgc:194989, Drer\zgc:163040, Drer\LOC570405, Drer\si:ch211-113a14.6, Drer\si:dkey-261m9.18" "Scer\HHF2, Scer\HHF1" "Cele\his-38, Cele\his-31, Cele\his-46, Cele\his-26, Cele\his-28, Cele\his-5, Cele\his-1, Cele\his-14, Cele\his-64, Cele\his-67, Cele\his-56, Cele\his-10, Cele\his-60, Cele\his-50, Cele\his-18, Cele\his-37" "Xtro\LOC100493041, Xtro\hist1h4c, Xtro\LOC101734147, Xtro\hist1h4k" "Mmus\Hist1h4h, Mmus\Hist1h4a, Mmus\Hist1h4b, Mmus\Hist1h4d, Mmus\Hist1h4n, Mmus\Hist1h4m, Mmus\Hist1h4c, Mmus\Hist1h4i, Mmus\Hist4h4, Mmus\Hist1h4k, Mmus\Hist1h4j, Mmus\Hist2h4, Mmus\Hist1h4f" "Hsap\HIST2H4B, Hsap\HIST1H4J, Hsap\HIST1H4D, Hsap\HIST1H4I, Hsap\HIST1H4B, Hsap\HIST1H4E, Hsap\HIST4H4, Hsap\HIST2H4A, Hsap\HIST1H4G, Hsap\HIST1H4H, Hsap\HIST1H4F, Hsap\HIST1H4K, Hsap\HIST1H4C, Hsap\HIST1H4L, Hsap\HIST1H4A" FBgn0264075 tgo tango http://flybase.org/reports/FBgn0264075 protein_coding_gene "sequence-specific DNA binding ; GO:0043565 | inferred from direct assay sequence-specific DNA binding ; GO:0043565 | contributes_to inferred from direct assay protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with dysf myosin binding ; GO:0017022 | inferred from physical interaction with Myo10A transcription factor activity, sequence-specific DNA binding ; GO:0003700 | contributes_to inferred from physical interaction with trh RNA polymerase II transcription factor activity, sequence-specific DNA binding ; GO:0000981 | inferred from sequence or structural similarity with HGNC:700 protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with ss transcription factor activity, sequence-specific DNA binding ; GO:0003700 | contributes_to inferred from physical interaction with sim inferred from physical interaction with dysf inferred from physical interaction with trh protein heterodimerization activity ; GO:0046982 | traceable author statement transcription factor activity, sequence-specific DNA binding ; GO:0003700 | contributes_to inferred from direct assay transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ; GO:0001077 | contributes_to inferred from physical interaction with sim inferred from physical interaction with trh transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ; GO:0003705 | contributes_to inferred from direct assay protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with sim inferred from physical interaction with sima transcription factor activity, sequence-specific DNA binding ; GO:0003700 | traceable author statement" "regulation of transcription from RNA polymerase II promoter ; GO:0006357 | inferred from direct assay cellular response to insulin stimulus ; GO:0032869 | inferred from direct assay epithelial cell fate determination, open tracheal system ; GO:0007425 | non-traceable author statement peripheral nervous system development ; GO:0007422 | traceable author statement dendrite morphogenesis ; GO:0048813 | inferred from mutant phenotype regulation of transcription, DNA-templated ; GO:0006355 | inferred from direct assay limb development ; GO:0060173 | inferred from mutant phenotype positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 | inferred from mutant phenotype epithelial cell fate determination, open tracheal system ; GO:0007425 | traceable author statement brain development ; GO:0007420 | inferred from mutant phenotype oogenesis ; GO:0048477 | inferred from mutant phenotype open tracheal system development ; GO:0007424 | traceable author statement central nervous system development ; GO:0007417 | inferred from mutant phenotype regulation of R7 cell differentiation ; GO:0045676 | inferred from mutant phenotype neuron development ; GO:0048666 | inferred from mutant phenotype positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 | inferred from direct assay cellular response to hypoxia ; GO:0071456 | inferred from direct assay glial cell migration ; GO:0008347 | inferred from mutant phenotype negative regulation of transcription from RNA polymerase II promoter ; GO:0000122 | inferred from mutant phenotype muscle organ development ; GO:0007517 | inferred from mutant phenotype" "transcription factor complex ; GO:0005667 | inferred from electronic annotation with InterPro:IPR001067 cytoplasm ; GO:0005737 | inferred from electronic annotation with InterPro:IPR001067 protein complex ; GO:0043234 | inferred from physical interaction with dysf nucleus ; GO:0005634 | inferred from sequence or structural similarity with HGNC:700 nucleus ; GO:0005634 | inferred from direct assay nucleus ; GO:0005634 | inferred by curator from GO:0003700,GO:0043565" "tgo, Tgo, dARNT, dHIF-1beta, Arnt, ARNT, HIF-1beta, Hif1, TGO, DARNT, arnt, Tango, darnt, HIF-1, prd7, HIF1b, CG11987, dTgo, bHLHe4, jay, TGO_CYC, tgo/Arnt, HIF1B/ARNT" "IPR000014:PAS domain, IPR001067:Nuclear translocator, IPR011598:Myc-type, basic helix-loop-helix (bHLH) domain, IPR013767:PAS fold" CG11987 27-Aug-18 DroID_v2018_08 "Drer\arnt2, Drer\arnt, Drer\npas4a" - Cele\aha-1 "Xtro\arnt2, Xtro\arnt" "Mmus\Arnt, Mmus\Arnt2" "Hsap\ARNT, Hsap\ARNT2" " embryonic stage | stage 15 , embryonic stage | stage 14 , embryonic stage | <8-12 hr , embryonic stage , oogenesis stage " " embryonic peripheral nervous system

, embryonic maxillary segment

, embryonic antennal segment

, embryonic gnathal segment

, embryonic mandibular segment

, embryonic labial segment

, leg | anlagen

,

ubiquitous " " embryonic stage | stage 15 , embryonic stage | stage 14 , embryonic stage | stage 11-17 , embryonic stage , embryonic stage | stage 11 " " embryonic peripheral nervous system

, embryonic/larval tracheal system

, embryonic maxillary segment

, embryonic mandibular segment

,

ubiquitous , embryonic antennal segment

, dorsal vessel primordium

, supraesophageal ganglion

, embryonic labial segment

, tracheal pit | surrounding

, ventral nerve cord

, embryonic/larval posterior spiracle

" FBgn0086676 spin spinster http://flybase.org/reports/FBgn0086676 protein_coding_gene sphingolipid transporter activity ; GO:0046624 | inferred from biological aspect of ancestor with PANTHER:PTN001160264 transmembrane transport ; GO:0055085 | inferred from electronic annotation with InterPro:IPR011701 glial cell differentiation ; GO:0010001 | inferred from mutant phenotype nurse cell apoptotic process ; GO:0045476 | inferred from mutant phenotype glial cell migration ; GO:0008347 | inferred from mutant phenotype negative regulation of decapentaplegic signaling pathway ; GO:0090099 | inferred from genetic interaction with dpp inferred from genetic interaction with sax inferred from genetic interaction with tkv inferred from genetic interaction with Mad oogenesis ; GO:0048477 | inferred from mutant phenotype endosome to lysosome transport ; GO:0008333 | inferred from mutant phenotype lysosome organization ; GO:0007040 | inferred from mutant phenotype cellular response to starvation ; GO:0009267 | inferred from mutant phenotype synaptic vesicle endocytosis ; GO:0048488 | inferred from mutant phenotype regulation of synaptic growth at neuromuscular junction ; GO:0008582 | inferred from mutant phenotype larval central nervous system remodeling ; GO:0035193 | inferred from mutant phenotype regulation of programmed cell death ; GO:0043067 | inferred from mutant phenotype sphingosine-1-phosphate signaling pathway ; GO:0003376 | inferred from biological aspect of ancestor with PANTHER:PTN001160264 endocytosis ; GO:0006897 | inferred from mutant phenotype locomotion ; GO:0040011 | inferred from mutant phenotype peripheral nervous system development ; GO:0007422 | non-traceable author statement regulation of female receptivity ; GO:0045924 | inferred from mutant phenotype courtship behavior ; GO:0007619 | non-traceable author statement regulation of nurse cell apoptotic process ; GO:0045477 | inferred from mutant phenotype synaptic growth at neuromuscular junction ; GO:0051124 | inferred from mutant phenotype programmed cell death ; GO:0012501 | non-traceable author statement integral component of membrane ; GO:0016021 | inferred from electronic annotation with InterPro:IPR011701 vesicle ; GO:0031982 | inferred from direct assay late endosome membrane ; GO:0031902 | inferred from direct assay lysosomal membrane ; GO:0005765 | inferred from biological aspect of ancestor with PANTHER:PTN001160264 "spin, bnch, CG8428, Spin, l(2)k09905, l(2)10403, 25/11, l(2)k02511, l(2R)W5, l(2)W5" "IPR011701:Major facilitator superfamily, IPR020846:Major facilitator superfamily domain" CG8428 27-Aug-18 DroID_v2018_08 "Drer\spns3, Drer\spns2, Drer\spns1" "Scer\VBA5, Scer\HXT2, Scer\HXT10" "Cele\hpo-12, Cele\spin-3, Cele\F47B8.10, Cele\spin-2, Cele\spin-4, Cele\spin-1" "Xtro\spns2, Xtro\spns1" "Mmus\Spns1, Mmus\Spns3, Mmus\Spns2" "Hsap\SPNS1, Hsap\SPNS3, Hsap\SPNS2" FBgn0028979 tio tiptop http://flybase.org/reports/FBgn0028979 protein_coding_gene "nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR013087 chromatin binding ; GO:0003682 | inferred from biological aspect of ancestor with PANTHER:PTN000281113 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ; GO:0001078 | inferred from biological aspect of ancestor with PANTHER:PTN000281113" "negative regulation of transcription from RNA polymerase II promoter ; GO:0000122 | inferred from mutant phenotype compound eye development ; GO:0048749 | inferred from mutant phenotype epidermis morphogenesis ; GO:0048730 | inferred from mutant phenotype specification of segmental identity, head ; GO:0007380 | inferred from mutant phenotype Malpighian tubule stellate cell differentiation ; GO:0061330 | inferred from expression pattern Malpighian tubule stellate cell differentiation ; GO:0061330 | inferred from genetic interaction with tsh" nucleus ; GO:0005634 | inferred from direct assay "CG12630, tio, Tio" "IPR013087:Zinc finger C2H2-type, IPR027008:Teashirt family, IPR026807:Protein tiptop/teashirt" CG12630 27-Aug-18 DroID_v2018_08 "Drer\tshz1, Drer\tshz3a" - - "Xtro\tshz3, Xtro\tshz2" "Mmus\Tshz1, Mmus\Tshz3, Mmus\Tshz2" "Hsap\TSHZ2, Hsap\TSHZ1, Hsap\TSHZ3" "viable,fertile,visible,homeotic" "antennal disc,eye,ectopic,somatic clone,larval labial segment,T1 beard,denticle,heat sensitive,eye photoreceptor cell,ectopic | third instar larval stage" FBgn0020309 crol crooked legs http://flybase.org/reports/FBgn0020309 "FBgn0010573, FBgn0010685, FBgn0025949, FBgn0025978" protein_coding_gene nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR013087 "lateral inhibition ; GO:0046331 | inferred from mutant phenotype imaginal disc-derived wing morphogenesis ; GO:0007476 | inferred from mutant phenotype inferred from genetic interaction with if inferred from genetic interaction with mys cell adhesion ; GO:0007155 | inferred from mutant phenotype positive regulation of mitotic cell cycle ; GO:0045931 | inferred from mutant phenotype negative regulation of transcription, DNA-templated ; GO:0045892 | inferred from mutant phenotype regulation of transcription from RNA polymerase II promoter ; GO:0006357 | inferred from mutant phenotype negative regulation of Wnt signaling pathway ; GO:0030178 | inferred from genetic interaction with arm inferred from genetic interaction with Axn regulation of chromatin silencing ; GO:0031935 | inferred from mutant phenotype heterochromatin organization involved in chromatin silencing ; GO:0070868 | inferred from mutant phenotype" nucleus ; GO:0005634 | inferred from direct assay heterochromatin ; GO:0000792 | inferred from direct assay "CG14938, crol gamma, crol beta, crol alpha, clone 2.48, clone 1.74, anon-EST:Liang-2.48, anon-EST:Liang-1.74, l(2)s2346, l(2)04418, crol, Crol, ORE-15" "IPR013087:Zinc finger C2H2-type, IPR013083:Zinc finger, RING/FYVE/PHD-type" CG14938 27-Aug-18 DroID_v2018_08 "Drer\znf384l, Drer\znf366, Drer\drl, Drer\znf362b, Drer\si:rp71-1g18.1, Drer\zgc:113220, Drer\vezf1b, Drer\si:dkey-261j4.5, Drer\znf362a, Drer\gtf3aa, Drer\znf983, Drer\zgc:165515, Drer\si:dkey-33c14.6, Drer\si:ch211-119o8.6, Drer\zgc:66448" "Scer\ZAP1, Scer\PZF1, Scer\AZF1" "Cele\eor-1, Cele\lin-29, Cele\fezf-1, Cele\Y55F3AM.14, Cele\ehn-3, Cele\ztf-25, Cele\Y48G8AL.10, Cele\ztf-28, Cele\egl-43, Cele\sem-4, Cele\Y5F2A.4" "Xtro\LOC100489238, Xtro\znf384, Xtro\maz, Xtro\znf217, Xtro\znf362, Xtro\gtf3a, Xtro\vezf1" "Mmus\Gm14139, Mmus\Zfp532, Mmus\Zfp553, Mmus\Zfp820, Mmus\Zfp93, Mmus\Zfp273, Mmus\Gm4724, Mmus\Zfp90, Mmus\Gtf3a, Mmus\Zfp35, Mmus\AI987944, Mmus\Zfp623, Mmus\Zfp442, Mmus\Zkscan7, Mmus\Zfp420, Mmus\Zfp14, Mmus\Gm14322, Mmus\D130040H23Rik, Mmus\0610010B08Rik, Mmus\Zfp715, Mmus\Zfp943, Mmus\Gm6710, Mmus\Zfp981, Mmus\Zfp65, Mmus\Zfp82, Mmus\Gm14325, Mmus\Zfp788, Mmus\Gm14391, Mmus\LOC101056073, Mmus\Zfp689, Mmus\Zfp111, Mmus\Zfp109, Mmus\Gm14305, Mmus\Zfp967, Mmus\Zfp984, Mmus\Zfp182, Mmus\Zfp52, Mmus\Zfp987, Mmus\Zfp119a, Mmus\Zfp105, Mmus\Zfp612, Mmus\Zfp72, Mmus\AW146154, Mmus\Repin1, Mmus\Zfp748, Mmus\Zfp189, Mmus\Zfp119b, Mmus\Zfp112, Mmus\Zfp791, Mmus\Zfp345, Mmus\Zfp729a, Mmus\Zfp51, Mmus\Zfp846, Mmus\Gm10324, Mmus\Zfp37, Mmus\Zfp944, Mmus\Zfp59, Mmus\Zfp27, Mmus\Zfp382, Mmus\Zfp960, Mmus\Zfp968, Mmus\Zfp160, Mmus\Zfp738, Mmus\Zfp28, Mmus\Zfp617, Mmus\Zfp658, Mmus\Zfp933, Mmus\Zfp235, Mmus\Zfp971, Mmus\Zfp992, Mmus\Zfp947, Mmus\Zfp606, Mmus\Zfp11, Mmus\Zkscan16, Mmus\Zfp934, Mmus\Zfp879, Mmus\Zfp458, Mmus\Zfp60, Mmus\Zfp760, Mmus\Zfp2, Mmus\Zfp287, Mmus\Gm14308, Mmus\Zfp473, Mmus\Zfp334, Mmus\Zfp607b, Mmus\Zfp959, Mmus\Gm14124, Mmus\LOC102633156, Mmus\Zfp251, Mmus\Zfp551, Mmus\Zfp758, Mmus\Zfp932, Mmus\Zfp938, Mmus\Zfp808, Mmus\Zfp595, Mmus\Zfp975, Mmus\Zfp974, Mmus\Zfp53, Mmus\Zfp970, Mmus\Zfp366, Mmus\Zfp85, Mmus\Zfp30, Mmus\Zfp994, Mmus\Zfp629, Mmus\Zfp937, Mmus\Zfp930, Mmus\Zfp114, Mmus\Zfp583, Mmus\Zfp87, Mmus\Zfp39, Mmus\Zfp26, Mmus\Zfp872, Mmus\Zfp729b, Mmus\Zfp362, Mmus\Zfp958, Mmus\Zfp819, Mmus\Zfp184, Mmus\4930522L14Rik, Mmus\Vezf1, Mmus\Zfp709, Mmus\Rex2, Mmus\Zfp180, Mmus\Zfp759, Mmus\Zfp605, Mmus\Zfp457, Mmus\Zfp78, Mmus\Zfp873, Mmus\Zfp945, Mmus\Zfp980, Mmus\Gm13212, Mmus\Zfp560, Mmus\Zfp354c, Mmus\Zfp229, Mmus\Zfp677, Mmus\Zfp946, Mmus\Zfp790, Mmus\D3Ertd254e, Mmus\Zfp74, Mmus\Zfp708, Mmus\Zfp985, Mmus\Zfp712, Mmus\Rbak, Mmus\Zfp619, Mmus\Zfp607a, Mmus\Zfp936, Mmus\Gm14326, Mmus\Zfp418, Mmus\Zfp942, Mmus\Zfp341, Mmus\Zfp260, Mmus\Zfp948, Mmus\Maz, Mmus\Zfp54, Mmus\Zfp647, Mmus\Zfp719, Mmus\Zfp976, Mmus\Zfp7, Mmus\Zkscan1, Mmus\Zfp991, Mmus\Zfp40, Mmus\Zfp616, Mmus\Zfp780b, Mmus\Zfp600, Mmus\Gm10778, Mmus\Zfp534, Mmus\Zfp62, Mmus\Zfp799, Mmus\Zfp710, Mmus\Zfp12, Mmus\Zfp451" "Hsap\ZNF93, Hsap\ZNF429, Hsap\ZNF300, Hsap\ZNF737, Hsap\ZNF451, Hsap\ZNF468, Hsap\ZNF92, Hsap\ZNF594, Hsap\ZNF530, Hsap\ZNF132, Hsap\ZNF823, Hsap\ZNF43, Hsap\ZNF34, Hsap\VEZF1, Hsap\ZNF234, Hsap\ZNF233, Hsap\ZNF7, Hsap\ZNF420, Hsap\ZNF441, Hsap\ZFP28, Hsap\ZNF528, Hsap\ZNF586, Hsap\ZNF224, Hsap\ZNF614, Hsap\ZNF382, Hsap\ZNF26, Hsap\ZNF347, Hsap\ZNF433, Hsap\ZNF600, Hsap\ZNF805, Hsap\ZNF606, Hsap\ZNF141, Hsap\ZNF658, Hsap\ZNF418, Hsap\ZNF267, Hsap\ZNF557, Hsap\ZNF160, Hsap\ZNF615, Hsap\ZNF699, Hsap\ZNF543, Hsap\ZNF497, Hsap\ZNF879, Hsap\ZNF136, Hsap\ZNF417, Hsap\ZNF573, Hsap\ZNF480, Hsap\ZNF548, Hsap\ZNF484, Hsap\ZNF354C, Hsap\ZNF384, Hsap\ZNF680, Hsap\ZNF189, Hsap\ZNF776, Hsap\ZNF717, Hsap\ZNF490, Hsap\ZNF85, Hsap\ZNF81, Hsap\ZNF778, Hsap\ZNF560, Hsap\ZNF613, Hsap\ZNF211, Hsap\ZNF814, Hsap\ZNF565, Hsap\ZNF700, Hsap\ZNF732, Hsap\ZNF623, Hsap\ZNF529, Hsap\ZNF362, Hsap\ZNF563, Hsap\ZNF792, Hsap\ZNF510, Hsap\ZNF479, Hsap\ZNF679, Hsap\ZFP62, Hsap\ZNF35, Hsap\ZNF782, Hsap\ZNF630, Hsap\ZNF235, Hsap\ZNF676, Hsap\ZNF366, Hsap\ZNF473, Hsap\ZNF567, Hsap\ZNF98, Hsap\ZNF83, Hsap\ZNF264, Hsap\ZNF790, Hsap\ZNF383, Hsap\ZNF251, Hsap\ZKSCAN7, Hsap\ZNF256, Hsap\ZNF470, Hsap\ZNF799, Hsap\ZNF320, Hsap\ZNF71, Hsap\ZNF729, Hsap\ZNF284, Hsap\ZNF880, Hsap\ZFP2, Hsap\ZNF443, Hsap\ZNF649, Hsap\ZNF273, Hsap\ZNF112, Hsap\ZFP90, Hsap\ZNF229, Hsap\ZNF780A, Hsap\ZNF570, Hsap\ZNF626, Hsap\ZNF527, Hsap\ZNF749, Hsap\ZNF28, Hsap\ZNF45, Hsap\ZNF689, Hsap\ZNF226, Hsap\ZNF599, Hsap\ZNF629, Hsap\ZNF865, Hsap\ZNF583, Hsap\ZNF730, Hsap\ZNF665, Hsap\ZNF791, Hsap\ZNF33A, Hsap\ZNF878, Hsap\ZNF587, Hsap\ZNF222, Hsap\ZNF624, Hsap\ZFP30, Hsap\ZFP14, Hsap\ZNF682, Hsap\ZNF534, Hsap\ZNF91, Hsap\ZNF208, Hsap\ZNF107, Hsap\ZNF416, Hsap\ZNF155, Hsap\ZNF765, Hsap\ZNF257, Hsap\ZNF709, Hsap\ZNF568, Hsap\MAZ, Hsap\ZNF483, Hsap\ZNF431, Hsap\ZNF607, Hsap\ZNF627, Hsap\ZNF585A, Hsap\ZNF460, Hsap\ZNF430, Hsap\ZNF12, Hsap\ZNF44, Hsap\ZNF540, Hsap\ZNF260, Hsap\ZNF841, Hsap\ZNF182, Hsap\ZNF860, Hsap\ZNF611, Hsap\ZNF16, Hsap\ZNF552, Hsap\REPIN1, Hsap\ZNF708, Hsap\ZNF23, Hsap\ZNF117, Hsap\ZNF571, Hsap\ZNF816, Hsap\ZNF20, Hsap\ZNF506, Hsap\ZNF254, Hsap\ZNF701, Hsap\ZNF440, Hsap\ZNF695, Hsap\ZNF180, Hsap\ZNF225, Hsap\ZNF808, Hsap\ZNF845, Hsap\ZNF546, Hsap\ZSCAN26, Hsap\ZNF677, Hsap\ZNF605, Hsap\ZNF569, Hsap\ZNF549, Hsap\ZNF555, Hsap\ZNF331, Hsap\ZNF77, Hsap\ZNF135, Hsap\ZNF84, Hsap\ZNF337, Hsap\ZNF551, Hsap\ZNF850, Hsap\ZNF70, Hsap\ZNF41, Hsap\ZNF780B, Hsap\ZNF461, Hsap\ZNF544, Hsap\ZNF69, Hsap\ZNF195, Hsap\ZSCAN2, Hsap\ZNF33B, Hsap\ZNF184, Hsap\ZNF493, Hsap\ZNF99, Hsap\ZNF175, Hsap\ZNF439, Hsap\ZNF227, Hsap\ZNF716, Hsap\ZNF442, Hsap\ZNF268, Hsap\ZNF79, Hsap\GTF3A, Hsap\ZNF710, Hsap\ZNF616, Hsap\ZNF287, Hsap\ZNF678, Hsap\ZNF763, Hsap\ZNF502, Hsap\ZNF766, Hsap\ZKSCAN1, Hsap\ZNF471, Hsap\ZNF681, Hsap\ZNF250, Hsap\ZNF836, Hsap\ZNF852, Hsap\ZNF223, Hsap\ZNF813, Hsap\ZNF14, Hsap\ZNF304, Hsap\ZNF492, Hsap\ZNF30, Hsap\ZNF714, Hsap\RBAK, Hsap\ZNF675, Hsap\ZNF197" " larval stage | third instar , prepupal stage " "viable,fertile,lethal,recessive,mitotic cell cycle defective,somatic clone,long lived,male limited,starvation stress response defective,temperature response defective,gravitaxis defective,female limited,lethal - all die before end of pupal stage,some die during pupal stage,neuroanatomy defective,visible,increased cell death,cell death defective,partially lethal - majority die" "wing vein,ectopic,ventral thoracic disc,leg,wing,femur,wing pouch,somatic clone,macrochaeta,stage P5 pupa,pupa,adult head,stage P14 pharate adult,metathoracic leg,metathoracic femur,metathoracic leg sensillum,intersegmental nerve,posterior compartment,wing disc,morphogenetic furrow,chaeta,supernumerary,mesothoracic tergum" DRSC21348 K -0.963320905 -0.071652027 -0.315914999 1.041765843 -1.634031783 -1.546821786 FBgn0004378 Klp61F Kinesin-like protein at 61F http://flybase.org/reports/FBgn0004378 "FBgn0004923, FBgn0010911, FBgn0015744" protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR001752, InterPro:IPR019821 microtubule binding ; GO:0008017 | inferred from direct assay ATP-dependent microtubule motor activity, plus-end-directed ; GO:0008574 | inferred from direct assay motor activity ; GO:0003774 | inferred from direct assay microtubule motor activity ; GO:0003777 | inferred from sequence or structural similarity ATP-dependent microtubule motor activity, plus-end-directed ; GO:0008574 | inferred from biological aspect of ancestor with PANTHER:PTN000649234 protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:P54350" Golgi organization ; GO:0007030 | inferred from mutant phenotype plus-end directed microtubule sliding ; GO:0031535 | inferred from direct assay mitotic nuclear division ; GO:0007067 | inferred from mutant phenotype microtubule-based movement ; GO:0007018 | inferred from direct assay adult chitin-containing cuticle pigmentation ; GO:0048085 | inferred from mutant phenotype mitotic centrosome separation ; GO:0007100 | inferred from mutant phenotype inferred from genetic interaction with ncd protein homotetramerization ; GO:0051289 | inferred from direct assay microtubule-based movement ; GO:0007018 | inferred from sequence or structural similarity centrosome separation ; GO:0051299 | inferred from mutant phenotype mitotic spindle assembly ; GO:0090307 | inferred from biological aspect of ancestor with PANTHER:PTN000649235 mitotic spindle organization ; GO:0007052 | inferred from mutant phenotype mitotic cell cycle ; GO:0000278 | inferred from mutant phenotype chromosome segregation ; GO:0007059 | inferred from biological aspect of ancestor with PANTHER:PTN000649235 microtubule bundle formation ; GO:0001578 | inferred from direct assay fusome organization ; GO:0045478 | inferred from mutant phenotype centrosome duplication ; GO:0051298 | inferred from mutant phenotype protein secretion ; GO:0009306 | inferred from mutant phenotype positive regulation of Golgi to plasma membrane protein transport ; GO:0042998 | inferred from mutant phenotype neurogenesis ; GO:0022008 | inferred from mutant phenotype fusome ; GO:0045169 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay kinesin complex ; GO:0005871 | inferred from sequence or structural similarity spindle ; GO:0005819 | inferred from direct assay mitotic spindle pole ; GO:0097431 | inferred from direct assay mitotic spindle ; GO:0072686 | inferred from direct assay endoplasmic reticulum ; GO:0005783 | inferred from direct assay mitotic spindle microtubule ; GO:1990498 | inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay aster ; GO:0005818 | inferred from direct assay kinesin complex ; GO:0005871 | inferred from direct assay microtubule associated complex ; GO:0005875 | inferred from direct assay centrosome ; GO:0005813 | colocalizes_with inferred from direct assay Golgi apparatus ; GO:0005794 | inferred from direct assay microtubule ; GO:0005874 | inferred from direct assay "KLP61f, klp61f, DmKLP61F, KLP61F, CG9191, DmKlp61F, Klp61F/KRP130, KLP61, 6345, KRP[[130]], KRP130, DmKRP130, urcn, KRP[[(130)]], KLP2, urc, l(3)07012, Krp130, Klp2, Klp61F, CG9191-PA, klp61F, Klp61f, l(3)6D283, l(3)Klp61F, Klp 61F, KIF 8, Kin-5, KIF11" "IPR025901:Kinesin-associated microtubule-binding domain, IPR001752:Kinesin motor domain, IPR019821:Kinesin motor domain, conserved site, IPR027417:P-loop containing nucleoside triphosphate hydrolase" CG9191 27-Aug-18 DroID_v2018_08 "Drer\kif3a, Drer\kif11" "Scer\CIN8, Scer\KIP1" "Cele\klp-20, Cele\bmk-1" Xtro\kif11 "Mmus\Kif11, Mmus\Kif3a" "Hsap\KIF11, Hsap\KIF3A" " embryonic stage && larval stage && pupal stage , adult stage | female , adult stage | male , embryonic stage , embryonic stage | stage 6 " " ovary

, testis

, ventral midline

, ventral nervous system | restricted

, mesoderm anlage

, cephalic furrow

" "viable,fertile,lethal - all die before end of second instar larval stage,recessive,some die during second instar larval stage,lethal - all die before end of embryonic stage,some die during embryonic stage,lethal,mitotic cell cycle defective,lethal - all die before end of larval stage,some die during larval stage,cytokinesis defective,lethal - all die before end of pupal stage,some die during pupal stage,somatic clone,neuroanatomy defective" "spindle | embryonic stage,spindle | embryonic stage, with Klp61F07012,spermatocyte fusome,nuclear chromosome,embryonic/larval brain,imaginal disc,centriole & spermatocyte,aster & spermatocyte,spindle & spermatocyte,centrosome & spermatocyte,spermatocyte,spermatid,spindle,mitotic cell cycle & spermatocyte,meiotic telophase II & spermatocyte,nuclear lamina & spermatocyte,spindle & neuroblast & larva,nuclear lamina & neuroblast & larva,aster & neuroblast & larva,centrosome & neuroblast & larva,embryonic/larval neuroblast,spindle | pre-blastoderm stage,spindle microtubule | embryonic stage 4,aster & spermatocytebab-PG),spindle & spermatocytebab-PG),centrosome & spermatocytebab-PG),microtubule organizing center | pre-blastoderm stage,spindle | embryonic stage, with Klp61FUbi-p63E.TAvicGFP/Klp61F06836,testis,larval brain & nuclear chromosome & larva,somatic clone,spindle microtubule,astral microtubule,mitosis & nuclear chromosome,spindle pole,S2 cell-line,ganglion mother cell" DRSC08671 IE 1.72234719 -2.332438086 0.869235011 -3.139821157 0.143621329 1.224654645 FBgn0283472 S6k Ribosomal protein S6 kinase http://flybase.org/reports/FBgn0283472 protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290, InterPro:IPR017441, InterPro:IPR017892 ribosomal protein S6 kinase activity ; GO:0004711 | inferred from sequence or structural similarity protein serine/threonine kinase activity ; GO:0004674 | non-traceable author statement protein serine/threonine kinase activity ; GO:0004674 | inferred from biological aspect of ancestor with PANTHER:PTN000682064 ribosomal protein S6 kinase activity ; GO:0004711 | inferred from sequence or structural similarity inferred from direct assay protein serine/threonine kinase activity ; GO:0004674 | inferred from sequence or structural similarity protein binding ; GO:0005515 | inferred from physical interaction with Tak1" dendrite morphogenesis ; GO:0048813 | inferred from mutant phenotype multicellular organism growth ; GO:0035264 | inferred from mutant phenotype growth ; GO:0040007 | inferred from mutant phenotype response to nutrient ; GO:0007584 | traceable author statement positive regulation of macroautophagy ; GO:0016239 | inferred from mutant phenotype cellular response to DNA damage stimulus ; GO:0006974 | inferred from mutant phenotype positive regulation of cell size ; GO:0045793 | non-traceable author statement positive regulation of cell growth ; GO:0030307 | traceable author statement protein phosphorylation ; GO:0006468 | non-traceable author statement actin filament organization ; GO:0007015 | inferred from mutant phenotype positive regulation of cell size ; GO:0045793 | inferred from mutant phenotype positive regulation of organ growth ; GO:0046622 | non-traceable author statement larval feeding behavior ; GO:0030536 | inferred from mutant phenotype synaptic growth at neuromuscular junction ; GO:0051124 | inferred from mutant phenotype positive regulation of growth ; GO:0045927 | traceable author statement protein phosphorylation ; GO:0006468 | inferred from direct assay positive regulation of organ growth ; GO:0046622 | traceable author statement protein phosphorylation ; GO:0006468 | inferred from sequence or structural similarity regulation of response to drug ; GO:2001023 | inferred from mutant phenotype determination of adult lifespan ; GO:0008340 | inferred from mutant phenotype positive regulation of cell growth ; GO:0030307 | non-traceable author statement phagocytosis ; GO:0006909 | inferred from mutant phenotype somatic muscle development ; GO:0007525 | inferred from mutant phenotype positive regulation of autophagy ; GO:0010508 | inferred from mutant phenotype positive regulation of cell size ; GO:0045793 | traceable author statement myoblast fusion ; GO:0007520 | inferred from mutant phenotype axon guidance ; GO:0007411 | inferred from genetic interaction with Rheb positive regulation of multicellular organism growth ; GO:0040018 | traceable author statement lipid metabolic process ; GO:0006629 | inferred from mutant phenotype regulation of cell size ; GO:0008361 | traceable author statement oogenesis ; GO:0048477 | inferred from mutant phenotype intracellular signal transduction ; GO:0035556 | inferred from biological aspect of ancestor with PANTHER:PTN000682064 positive regulation of cell size ; GO:0045793 | inferred from mutant phenotype inferred from genetic interaction with gig response to oxidative stress ; GO:0006979 | inferred from direct assay regulation of terminal button organization ; GO:2000331 | inferred from mutant phenotype nucleus ; GO:0005634 | inferred from biological aspect of ancestor with PANTHER:PTN000682064 cytoplasm ; GO:0005737 | inferred from biological aspect of ancestor with PANTHER:PTN000682064 nucleoplasm ; GO:0005654 | inferred from direct assay presynaptic active zone ; GO:0048786 | inferred from direct assay cytosol ; GO:0005829 | inferred from direct assay "S6k, S6K, dS6K, S6K1, s6k, p70/S6K, CG10539, dS6k, ds6k, s6k11, p70 S6K, DS6K, p70[S6kinase], p70[S6 kinase], fs(3)07084, Dp70s6k, p70s6K, dps6k, dp70s6k, 7084, p70[S6k], p70S6K, Dp70[s6k], Dp70S6k, dp70[S6k], l(3)07084, p70[S6K], 10539, S6k|S6K, 7-10, Pk?6, Pk64F, p-S6K" "IPR000719:Protein kinase domain, IPR000961:AGC-kinase, C-terminal, IPR008271:Serine/threonine-protein kinase, active site, IPR011009:Protein kinase-like domain, IPR016238:Ribosomal protein S6 kinase, IPR017441:Protein kinase, ATP binding site, IPR017892:Protein kinase, C-terminal" CG10539 27-Aug-18 DroID_v2018_08 "Drer\rps6kal, Drer\sgk2a, Drer\akt2, Drer\rps6ka3a, Drer\stk32a, Drer\rps6ka4, Drer\rps6ka3b, Drer\akt3b, Drer\akt3a, Drer\rps6kb1b, Drer\sgk2b, Drer\sgk1, Drer\rps6ka2, Drer\akt2l, Drer\rps6kb1a, Drer\rps6ka1, Drer\sgk3, Drer\rps6ka5, Drer\si:ch211-195b13.1, Drer\LOC100331306" "Scer\YPK3, Scer\YPK1, Scer\SCH9, Scer\YPK2" "Cele\akt-1, Cele\akt-2, Cele\ceh-93, Cele\rskn-1, Cele\R04A9.7, Cele\sgk-1, Cele\rsks-1, Cele\F28C10.3, Cele\rskn-2" "Xtro\rps6ka1, Xtro\rps6ka2, Xtro\stk32a, Xtro\sgk2, Xtro\sgk1, Xtro\rps6ka4, Xtro\rps6kb1, Xtro\rps6ka6, Xtro\akt1, Xtro\akt2, Xtro\rps6ka3" "Mmus\Rps6ka3, Mmus\Sgk1, Mmus\Stk32b, Mmus\Rps6kb1, Mmus\Rps6ka4, Mmus\Rps6kb2, Mmus\Rps6ka5, Mmus\Rps6ka1, Mmus\Rps6ka6, Mmus\Sgk3, Mmus\Akt3, Mmus\Stk32c, Mmus\Sgk2, Mmus\Akt2, Mmus\Rps6ka2, Mmus\Akt1, Mmus\Stk32a" "Hsap\STK32B, Hsap\RPS6KA3, Hsap\AKT2, Hsap\RPS6KA1, Hsap\RPS6KA6, Hsap\RPS6KB1, Hsap\RPS6KB2, Hsap\SGK2, Hsap\AKT3, Hsap\AKT1, Hsap\STK32A, Hsap\RPS6KA2, Hsap\SGK1, Hsap\SGK3, Hsap\STK32C, Hsap\RPS6KA5, Hsap\RPS6KA4" "viable,small body,visible,neurophysiology defective,partially lethal - majority die,recessive,female sterile,lethal,partially,decreased cell size,lethal - all die before end of larval stage,some die during larval stage,size defective,decreased cell number,wild-type,cell autonomous,somatic clone,neuroanatomy defective,feeding behavior defective,long lived,increased cell number,increased cell size,large body,increased cell growth,chemical resistant,short lived,memory defective,heat sensitive" "segment border muscle,A1-7 dorsal acute muscle 1,embryonic/larval somatic muscle,embryonic myoblast,wing,oocyte,adult,wing & cell | somatic clone,ommatidium,somatic clone,cell | adult stage,wing & cell,wing disc,mitotic cell cycle | somatic clone,eye,larval salivary gland & nucleus,dendrite | somatic clone,dendritic arborizing neuron,embryonic/larval fat body,NMJ bouton,wing blade,salivary gland,trichogen cell" DRSC11276 I -1.527743561 2.457851183 -0.911281262 -1.151322699 0.056746863 0.686103813 FBgn0053866 His3:CG33866 His3:CG33866 http://flybase.org/reports/FBgn0053866 protein_coding_gene protein heterodimerization activity ; GO:0046982 | inferred from electronic annotation with InterPro:IPR009072 nucleosomal DNA binding ; GO:0031492 | inferred from sequence or structural similarity with UniProtKB:P84243 nucleosome assembly ; GO:0006334 | inferred from sequence or structural similarity with UniProtKB:P84243 nuclear nucleosome ; GO:0000788 | inferred from sequence or structural similarity with UniProtKB:P84243 "CG33866, His3:CG33866, His3" "IPR000164:Histone H3/CENP-A, IPR009072:Histone-fold, IPR007125:Histone H2A/H2B/H3" CG33866 27-Aug-18 DroID_v2018_08 "Drer\h3f3b.1, Drer\hist2h3ca1, Drer\si:dkey-108k21.25, Drer\zgc:113983, Drer\si:ch1073-429i10.3, Drer\cenpa, Drer\h3f3c, Drer\hist2h3c, Drer\LOC108190747, Drer\zgc:113984, Drer\LOC108190746, Drer\zgc:173552, Drer\si:ch73-36p18.2, Drer\h3f3d, Drer\h3f3a" "Scer\CSE4, Scer\HHT2, Scer\HHT1" "Cele\his-74, Cele\his-59, Cele\his-13, Cele\his-9, Cele\his-69, Cele\his-40, Cele\his-25, Cele\his-63, Cele\his-27, Cele\his-72, Cele\his-45, Cele\his-17, Cele\his-71, Cele\his-6, Cele\his-2, Cele\his-32, Cele\his-55, Cele\his-42, Cele\his-49" "Xtro\hist2h3d, Xtro\LOC100486113, Xtro\hist2h3c, Xtro\cenpa, Xtro\h3f3b" "Mmus\Hist1h3g, Mmus\Hist2h3c2, Mmus\Hist1h3d, Mmus\Hist1h3b, Mmus\Hist1h3f, Mmus\H3f3b, Mmus\Cenpa, Mmus\Hist2h3b, Mmus\Hist1h3h, Mmus\Hist1h3a, Mmus\Hist1h3i, Mmus\Hist1h3e, Mmus\H3f3a, Mmus\Hist1h3c, Mmus\Hist2h3c1, Mmus\Hist2h2be" "Hsap\H3F3C, Hsap\HIST2H3C, Hsap\HIST1H3B, Hsap\HIST1H3J, Hsap\HIST1H3D, Hsap\HIST2H3A, Hsap\HIST1H3F, Hsap\HIST3H3, Hsap\H3F3B, Hsap\HIST1H3C, Hsap\HIST1H3I, Hsap\H3F3A, Hsap\HIST1H3G, Hsap\CENPA, Hsap\HIST1H3E, Hsap\HIST1H3H, Hsap\HIST1H3A, Hsap\HIST2H3D" FBgn0265726 Nna1 Nna1 carboxypeptidase http://flybase.org/reports/FBgn0265726 protein_coding_gene metallocarboxypeptidase activity ; GO:0004181 | inferred from electronic annotation with InterPro:IPR000834 zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR000834 proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR000834 mitochondrion organization ; GO:0007005 | inferred from mutant phenotype larval development ; GO:0002164 | inferred from mutant phenotype neural retina development ; GO:0003407 | inferred from mutant phenotype mitochondrion ; GO:0005739 | inferred from direct assay "CG44533, CG11428, CG32627, CG32628, NnaD, Nna1" "IPR000834:Peptidase M14, carboxypeptidase A" CG44533 27-Aug-18 DroID_v2018_08 "Drer\tpst1l, Drer\tpst1, Drer\agbl2, Drer\agtpbp1, Drer\agbl5" - "Cele\tpst-1, Cele\ccpp-1" "Xtro\agtpbp1, Xtro\agbl2, Xtro\agbl1, Xtro\agbl5" "Mmus\Agtpbp1, Mmus\Agbl1, Mmus\Agbl3, Mmus\Agbl4, Mmus\Tpst1, Mmus\Tpst2, Mmus\Agbl2, Mmus\Agbl5" "Hsap\AGBL3, Hsap\AGBL5, Hsap\AGBL2, Hsap\AGTPBP1, Hsap\AGBL1, Hsap\AGBL4, Hsap\TPST2, Hsap\TPST1" DRSC19404 K -0.17179376 0.465275645 -0.257684559 0.76096315 2.386751242 -0.25729871 FBgn0032162 CG4592 - http://flybase.org/reports/FBgn0032162 protein_coding_gene enoyl-CoA hydratase activity ; GO:0004300 | inferred from biological aspect of ancestor with PANTHER:PTN000941828 fatty acid beta-oxidation ; GO:0006635 | inferred from biological aspect of ancestor with PANTHER:PTN000941828 mitochondrion ; GO:0005739 | inferred from biological aspect of ancestor with PANTHER:PTN000941570 CG4592 "IPR001753:Crotonase superfamily, IPR029045:ClpP/crotonase-like domain" CG4592 27-Aug-18 DroID_v2018_08 Drer\eci1 - - Xtro\eci1 Mmus\Eci1 Hsap\ECI1 viable FBgn0053809 His3:CG33809 His3:CG33809 http://flybase.org/reports/FBgn0053809 protein_coding_gene protein heterodimerization activity ; GO:0046982 | inferred from electronic annotation with InterPro:IPR009072 nucleosomal DNA binding ; GO:0031492 | inferred from sequence or structural similarity with UniProtKB:P84243 nucleosome assembly ; GO:0006334 | inferred from sequence or structural similarity with UniProtKB:P84243 nuclear nucleosome ; GO:0000788 | inferred from sequence or structural similarity with UniProtKB:P84243 "CG33809, His3:CG33809" "IPR000164:Histone H3/CENP-A, IPR009072:Histone-fold, IPR007125:Histone H2A/H2B/H3" CG33809 27-Aug-18 DroID_v2018_08 "Drer\hist2h3ca1, Drer\h3f3b.1, Drer\h3f3a, Drer\zgc:113984, Drer\LOC108190746, Drer\hist2h3c, Drer\cenpa, Drer\LOC108190747, Drer\h3f3d, Drer\si:ch73-36p18.2, Drer\zgc:113983, Drer\zgc:173552, Drer\h3f3c, Drer\si:ch1073-429i10.3" "Scer\HHT1, Scer\HHT2, Scer\CSE4" "Cele\his-49, Cele\his-45, Cele\his-17, Cele\his-59, Cele\his-42, Cele\his-71, Cele\his-27, Cele\his-69, Cele\his-9, Cele\his-55, Cele\his-74, Cele\his-13, Cele\his-2, Cele\his-32, Cele\his-25, Cele\his-6, Cele\his-72, Cele\his-63" "Xtro\cenpa, Xtro\h3f3b, Xtro\hist2h3d" "Mmus\Hist1h3c, Mmus\Hist1h3i, Mmus\H3f3a, Mmus\H3f3b, Mmus\Hist1h3h, Mmus\Cenpa, Mmus\Hist1h3g, Mmus\Hist1h3a, Mmus\Hist1h3b, Mmus\Hist2h3c2, Mmus\Hist1h3e, Mmus\Hist1h3f, Mmus\Hist1h3d, Mmus\Hist2h3b, Mmus\Hist2h3c1" "Hsap\HIST1H3B, Hsap\HIST1H3E, Hsap\HIST1H3I, Hsap\HIST1H3F, Hsap\HIST1H3J, Hsap\CENPA, Hsap\HIST2H3D, Hsap\HIST1H3A, Hsap\HIST3H3, Hsap\HIST1H3D, Hsap\H3F3A, Hsap\H3F3C, Hsap\HIST1H3G, Hsap\HIST1H3C, Hsap\H3F3B, Hsap\HIST2H3A, Hsap\HIST1H3H, Hsap\HIST2H3C" FBgn0003124 polo polo http://flybase.org/reports/FBgn0003124 "FBgn0010758, FBgn0016019, FBgn0027987, FBgn0028177, FBgn0046400" protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290 protein serine/threonine kinase activity ; GO:0004674 | inferred from sequence or structural similarity protein kinase activity ; GO:0004672 | non-traceable author statement protein kinase activity ; GO:0004672 | inferred from direct assay protein serine/threonine kinase activity ; GO:0004674 | inferred from direct assay protein binding ; GO:0005515 | inferred from physical interaction with gwl" meiotic spindle midzone assembly ; GO:0051257 | inferred from mutant phenotype mitotic cell cycle ; GO:0000278 | inferred from mutant phenotype centrosome organization ; GO:0051297 | inferred from mutant phenotype protein localization ; GO:0008104 | non-traceable author statement oocyte fate commitment ; GO:0048600 | inferred from mutant phenotype sperm aster formation ; GO:0035044 | inferred from mutant phenotype pronuclear migration ; GO:0035046 | inferred from mutant phenotype pronuclear fusion ; GO:0007344 | inferred from mutant phenotype neurogenesis ; GO:0022008 | inferred from mutant phenotype mitotic cell cycle ; GO:0000278 | inferred from mutant phenotype inferred from genetic interaction with Map205 mitotic nuclear division ; GO:0007067 | inferred from mutant phenotype protein phosphorylation ; GO:0006468 | inferred from direct assay male meiosis ; GO:0007140 | inferred from mutant phenotype embryonic heart tube development ; GO:0035050 | inferred from mutant phenotype cellular protein localization ; GO:0034613 | inferred from mutant phenotype actomyosin contractile ring assembly ; GO:0000915 | inferred from mutant phenotype protein phosphorylation ; GO:0006468 | non-traceable author statement male meiosis cytokinesis ; GO:0007112 | inferred from mutant phenotype spindle assembly involved in female meiosis II ; GO:0007058 | inferred from mutant phenotype male germline ring canal formation ; GO:0030726 | inferred from mutant phenotype attachment of mitotic spindle microtubules to kinetochore ; GO:0051315 | inferred from direct assay astral microtubule nucleation ; GO:0030954 | inferred from mutant phenotype female meiotic division ; GO:0007143 | inferred from mutant phenotype phagocytosis ; GO:0006909 | inferred from mutant phenotype negative regulation of neuroblast proliferation ; GO:0007406 | inferred from mutant phenotype female meiosis II ; GO:0007147 | inferred from mutant phenotype midbody ; GO:0030496 | inferred from direct assay spindle pole ; GO:0000922 | inferred from direct assay centriole ; GO:0005814 | inferred from direct assay kinetochore ; GO:0000776 | inferred from direct assay microtubule ; GO:0005874 | inferred from direct assay mitotic spindle midzone ; GO:1990023 | inferred from direct assay centrosome ; GO:0005813 | inferred from direct assay condensed chromosome outer kinetochore ; GO:0000940 | inferred from direct assay condensed chromosome outer kinetochore ; GO:0000940 | non-traceable author statement spindle ; GO:0005819 | inferred from direct assay nuclear envelope ; GO:0005635 | inferred from direct assay kinetochore microtubule ; GO:0005828 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay centrosome ; GO:0005813 | kinetochore ; GO:0000776 | "polo, Polo, POLO, POLO/PLK1, CG12306, l(3)01673, 1324/08, 0256/04, l(3)77Aa, l(3)S132408, l(3)S025604, anon-WO0172774.3, Polo kinase, PLK1" "IPR000719:Protein kinase domain, IPR000959:POLO box domain, IPR008271:Serine/threonine-protein kinase, active site, IPR011009:Protein kinase-like domain, IPR033695:Second polo-box domain, IPR033701:First polo-box domain" CG12306 27-Aug-18 DroID_v2018_08 "Drer\plk2b, Drer\plk1, Drer\plk3, Drer\plk2a, Drer\plk4" Scer\CDC5 "Cele\plk-1, Cele\plk-3, Cele\plk-2" "Xtro\plk2, Xtro\plk1, Xtro\plk3, Xtro\plk4" "Mmus\Plk1, Mmus\Plk5, Mmus\Plk3, Mmus\Plk2, Mmus\Plk4" "Hsap\PLK1, Hsap\PLK2, Hsap\PLK3, Hsap\PLK4" " larval stage && spermatogenesis , embryonic stage -- adult stage , larval stage , embryonic stage | stage 4 , embryonic stage | blastoderm " " testis

, ventral nerve cord

, imaginal disc

, organism | ubiquitous

, larval optic lobe

, larval brain

" embryonic stage "mitotic cell cycle defective,lethal,recessive,lethal - all die before end of larval stage,some die during larval stage,hyperplasia,neuroanatomy defective,increased cell death,lethal - all die before end of pupal stage,some die during pupal stage,viable,sterile,somatic clone,cytokinesis defective,some die during third instar larval stage,female sterile,wild-type,male,meiotic cell cycle defective,female,reduced,cell cycle defective,partially lethal - majority die,partially lethal,maternal effect,some die during embryonic stage,lethal - all die before end of embryonic stage,dominant,visible" "neuroblast & centrosome & larva,testis,primary spermatocyte cyst,onion stage spermatid,Nebenkern,meiotic cell cycle & spindle | male,mitotic cell cycle,mitosis & nuclear chromosome,nuclear chromosome,aster,embryonic/larval cardial cell,neuroblast & larval brain,neuroblast & larval brain | somatic clone,spindle & neuroblast,germarium region 2a,synaptonemal complex,germarium region 3,adult abdomen,tergite,embryonic/larval neuroblast,embryonic/larval brain,macrochaeta,abdomen,germline cyst,meiotic cell cycle | female,polar body nucleus,spermatocyte & spindle,spermatocyte & pericentriolar material,spermatocyte & midbody,spermatid,neuroblast & mitotic anaphase & larva,meiosis II | female,meiotic metaphase II & spindle | female,meiosis II & aster | female,meiosis II & spindle | female,male pronucleus,female pronucleus,meiotic telophase II & contractile ring | female,spindle,centrosome,adult cuticle,germarium region 2b,germarium,type II neuroblast,somatic clone,supernumerary,egg,centrosome | embryonic stage 4,centrosome | embryonic stage 4 | maternal effect,ganglion mother cell,mesothoracic tergum" DRSC22359 EK 1.182863402 0.84616027 -0.441853429 -2.231780857 2.168500088 1.684353783 FBgn0065916 l(2)SH0168 lethal (2) SH0168 http://flybase.org/reports/FBgn0065916 gene - - - "l(2)SH0168, l(2)SH2 0168" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0053880 His2B:CG33880 His2B:CG33880 http://flybase.org/reports/FBgn0053880 protein_coding_gene protein heterodimerization activity ; GO:0046982 | inferred from electronic annotation with InterPro:IPR009072 DNA binding ; GO:0003677 | inferred from sequence or structural similarity with SGD_LOCUS:HTB1; SGD:S000002632 chromatin assembly or disassembly ; GO:0006333 | inferred from sequence or structural similarity with SGD_LOCUS:HTB1; SGD:S000002632 nuclear nucleosome ; GO:0000788 | inferred from sequence or structural similarity with SGD_LOCUS:HTB1; SGD:S000002632 "CG33880, His2B:CG33880" "IPR009072:Histone-fold, IPR000558:Histone H2B, IPR007125:Histone H2A/H2B/H3" CG33880 27-Aug-18 DroID_v2018_08 "Drer\si:dkey-108k21.27, Drer\si:ch211-113a14.11, Drer\si:dkey-23a13.1, Drer\zgc:92591, Drer\zgc:173585, Drer\hist1h2ba, Drer\si:dkey-23a13.5, Drer\si:ch73-368j24.8, Drer\si:ch1073-153i20.3, Drer\ano9a, Drer\si:dkey-23a13.16, Drer\zgc:173587, Drer\si:dkey-261m9.19, Drer\si:ch1073-159d7.13, Drer\LOC100334869, Drer\si:ch73-36p18.3, Drer\hist2h2l, Drer\LOC100334559, Drer\zgc:194989, Drer\zgc:114046, Drer\si:ch1073-159d7.5, Drer\si:ch211-113a14.29, Drer\LOC100329560, Drer\si:dkey-108k21.11, Drer\LOC100329290, Drer\si:dkey-261m9.6, Drer\si:ch211-113a14.28" "Scer\HTB2, Scer\HTB1" "Cele\his-11, Cele\his-41, Cele\his-66, Cele\his-8, Cele\his-22, Cele\his-15, Cele\his-44, Cele\his-54, Cele\his-39, Cele\his-52, Cele\his-20, Cele\his-34, Cele\his-58, Cele\his-4, Cele\his-62, Cele\his-48, Cele\his-29" "Xtro\LOC101734494, Xtro\LOC100485294, Xtro\LOC100498647, Xtro\LOC101731959, Xtro\LOC100496181, Xtro\LOC100498072, Xtro\hist1h2bm, Xtro\LOC101733489, Xtro\LOC100498553, Xtro\hist1h2bk, Xtro\LOC100495041, Xtro\LOC100495396, Xtro\LOC100495578, Xtro\LOC101731067, Xtro\LOC100485134, Xtro\LOC100498329, Xtro\LOC101734862, Xtro\LOC100496445, Xtro\hist1h2bj, Xtro\LOC100486150, Xtro\LOC101735218, Xtro\LOC100495415, Xtro\hist2h2be, Xtro\LOC101730940, Xtro\LOC100496436, Xtro\LOC100497915, Xtro\LOC101733171, Xtro\LOC101735164, Xtro\LOC100492632, Xtro\LOC100486870, Xtro\LOC101733828, Xtro\LOC101731852, Xtro\LOC100497082, Xtro\LOC100487485" "Mmus\Hist2h2be, Mmus\Hist1h2bp, Mmus\Hist1h2bb, Mmus\Hist1h2be, Mmus\Hist3h2ba, Mmus\1700024P04Rik, Mmus\Hist1h2bl, Mmus\Hist1h2bq, Mmus\Hist1h2bk, Mmus\Hist1h2bj, Mmus\Hist2h2bb, Mmus\Hist1h2bm, Mmus\Hist1h2ba, Mmus\Hist1h2bn, Mmus\H2bfm, Mmus\Hist1h2bf, Mmus\Hist1h2bh, Mmus\Hist1h2bc, Mmus\Hist1h2br, Mmus\Hist1h2bg" "Hsap\HIST1H2BM, Hsap\HIST1H2BL, Hsap\HIST2H2BF, Hsap\HIST1H2BC, Hsap\HIST1H2BK, Hsap\H2BFWT, Hsap\HIST1H2BO, Hsap\HIST1H2BA, Hsap\HIST1H2BF, Hsap\H2BFM, Hsap\HIST1H2BH, Hsap\HIST1H2BB, Hsap\HIST1H2BN, Hsap\HIST1H2BJ, Hsap\HIST1H2BG, Hsap\HIST3H2BB, Hsap\HIST1H2BI, Hsap\HIST1H2BE, Hsap\HIST1H2BD, Hsap\HIST2H2BE" FBgn0041188 Atx2 Ataxin-2 http://flybase.org/reports/FBgn0041188 protein_coding_gene protein binding ; GO:0005515 | inferred from physical interaction with tyf short-term memory ; GO:0007614 | NOT inferred from mutant phenotype long-term memory ; GO:0007616 | inferred from mutant phenotype locomotor rhythm ; GO:0045475 | inferred from mutant phenotype positive regulation of neuron death ; GO:1901216 | inferred from mutant phenotype chaeta development ; GO:0022416 | inferred from mutant phenotype habituation ; GO:0046959 | inferred from mutant phenotype circadian regulation of translation ; GO:0097167 | inferred from mutant phenotype inferred from physical interaction with tyf oocyte differentiation ; GO:0009994 | inferred from mutant phenotype compound eye development ; GO:0048749 | inferred from mutant phenotype positive regulation of protein binding ; GO:0032092 | inferred from mutant phenotype regulation of synapse structural plasticity ; GO:0051823 | inferred from mutant phenotype neurogenesis ; GO:0022008 | inferred from mutant phenotype regulation of cytoplasmic mRNA processing body assembly ; GO:0010603 | inferred from biological aspect of ancestor with PANTHER:PTN000304339 circadian regulation of translation ; GO:0097167 | inferred from genetic interaction with per inferred from genetic interaction with tyf compound eye photoreceptor development ; GO:0042051 | inferred from mutant phenotype stress granule assembly ; GO:0034063 | inferred from biological aspect of ancestor with PANTHER:PTN000304339 negative regulation of gene silencing by miRNA ; GO:0060965 | inferred from mutant phenotype phagocytosis ; GO:0006909 | inferred from mutant phenotype regulation of olfactory learning ; GO:0090328 | inferred from mutant phenotype sleep ; GO:0030431 | inferred from expression pattern regulation of actin filament polymerization ; GO:0030833 | inferred from mutant phenotype cytoplasmic stress granule ; GO:0010494 | inferred from biological aspect of ancestor with PANTHER:PTN000304339 cytoplasm ; GO:0005737 | inferred from direct assay "dAtx2, CG5166, SCA2, Datx2, GH27029, dSCA2, Sca2, l(3)06490, atx2, anon-EST:fe2E1, BEST:GH27029, anon-WO0140519.1, anon-WO0118547.351, Atx2, CG5166a, ATX2, Atxain-2, Atx-2, atx-2" "IPR009604:LsmAD domain, IPR025852:Ataxin 2, SM domain, IPR015943:WD40/YVTN repeat-like-containing domain, IPR009818:Ataxin-2, C-terminal" CG5166 27-Aug-18 DroID_v2018_08 "Drer\atxn2l, Drer\atxn2" "Scer\PBP1, Scer\AIM3" Cele\atx-2 "Xtro\atxn2l, Xtro\atxn2" "Mmus\Atxn2l, Mmus\Maml1, Mmus\Atxn2" "Hsap\ATXN2L, Hsap\ATXN2" "viable,lethal,recessive,visible,somatic clone,female sterile,germline clone,lethal - all die before end of larval stage,some die during larval stage,increased cell death,uncoordinated,partially lethal - majority die,decreased cell number,conditional,neuroanatomy defective,lethal - all die before end of pupal stage,some die during pupal stage,circadian behavior defective,learning defective,heat sensitive,locomotor rhythm defective" "eye,somatic clone,ommatidium,nurse cell,germline clone,oocyte,nurse cell & nucleus | germ-line clone,nurse cell & actin filament | germ-line clone,retina,eye disc,border follicle cell,adult thorax & chaeta, with Atx2UAS.cSa, [-],adult thorax & chaeta, with Atx2X1, [-],head,photoreceptor,conditional,embryonic/larval neuroblast" DRSC23010 K -0.179759034 1.948302039 FBgn0000257 car carnation http://flybase.org/reports/FBgn0000257 "FBgn0027357, FBgn0040160" protein_coding_gene protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q24314 syntaxin binding ; GO:0019905 | inferred from physical interaction with Syx16 syntaxin binding ; GO:0019905 | contributes_to inferred from physical interaction with Syx17 SNARE binding ; GO:0000149 | inferred from sequence or structural similarity vesicle docking involved in exocytosis ; GO:0006904 | inferred from electronic annotation with InterPro:IPR001619 endosomal transport ; GO:0016197 | inferred from sequence or structural similarity with SGD:S000004388 protein targeting to lysosome ; GO:0006622 | inferred from mutant phenotype cellular response to starvation ; GO:0009267 | inferred from mutant phenotype eye pigment granule organization ; GO:0008057 | inferred from mutant phenotype endosome to lysosome transport ; GO:0008333 | traceable author statement compound eye pigmentation ; GO:0048072 | inferred from mutant phenotype endosome organization ; GO:0007032 | inferred from mutant phenotype compound eye pigmentation ; GO:0048072 | inferred from genetic interaction with p autophagosome maturation ; GO:0097352 | inferred from mutant phenotype negative regulation of Notch signaling pathway ; GO:0045746 | inferred from mutant phenotype ommochrome biosynthetic process ; GO:0006727 | inferred from mutant phenotype regulation of Notch signaling pathway ; GO:0008593 | inferred from genetic interaction with l(2)gd1 determination of adult lifespan ; GO:0008340 | inferred from mutant phenotype vesicle-mediated transport ; GO:0016192 | inferred from sequence or structural similarity endosome to lysosome transport ; GO:0008333 | inferred from mutant phenotype regulation of protein ubiquitination ; GO:0031396 | inferred from mutant phenotype compound eye pigmentation ; GO:0048072 | traceable author statement endocytosis ; GO:0006897 | inferred from mutant phenotype intracellular transport ; GO:0046907 | traceable author statement Notch receptor processing ; GO:0007220 | inferred from mutant phenotype regulation of SNARE complex assembly ; GO:0035542 | inferred from sequence or structural similarity with SGD:S000004388 membrane ; GO:0016020 | traceable author statement cytosol ; GO:0005829 | traceable author statement CORVET complex ; GO:0033263 | inferred from sequence or structural similarity with SGD:S000004388 HOPS complex ; GO:0030897 | inferred from direct assay lysosome ; GO:0005764 | inferred from direct assay HOPS complex ; GO:0030897 | inferred from mutant phenotype HOPS complex ; GO:0030897 | inferred from sequence or structural similarity with SGD:S000004388 "car, Vps33/carnation, Vps33p, Vps33, Dm-Vps33, l(1)G0447, CG12230, carn, VPS33a, Vps33a, Vps33A, Car" "IPR001619:Sec1-like protein, IPR027121:Vacuolar protein sorting-associated protein 33" CG12230 27-Aug-18 DroID_v2018_08 "Drer\vps33a, Drer\vps33b" Scer\VPS33 "Cele\vps-33.2, Cele\vps-33.1" "Xtro\vps33b, Xtro\vps33a" "Mmus\Vps33a, Mmus\Vps33b" "Hsap\VPS33B, Hsap\VPS33A" "viable,fertile,partially lethal - majority die,recessive,visible,short lived,male,eye color defective,decreased cell death,wild-type,somatic clone,lethal - all die before end of second instar larval stage,some die during second instar larval stage,some die during pupal stage,lethal - all die before end of pupal stage" "eye,late endosome,pigment cell,Malpighian tubule,embryonic/larval brain,endosome,ommatidium,rhabdomere,spermatogonial cyst,male germline cell,somatic clone,rhabdomere | cell autonomous | somatic clone,wing,mesothoracic tergum,embryonic/larval fat body,nutrition conditional,autolysosome | somatic clone | wandering third instar larval stage | nutrition conditionalFRT.RnorCD2.Act5C" FBgn0015247 Diap2 Death-associated inhibitor of apoptosis 2 http://flybase.org/reports/FBgn0015247 - protein_coding_gene zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR001841 cysteine-type endopeptidase inhibitor activity involved in apoptotic process ; GO:0043027 | inferred from direct assay ubiquitin protein ligase activity ; GO:0061630 | inferred from direct assay caspase binding ; GO:0089720 | inferred from physical interaction with Drice zinc ion binding ; GO:0008270 | inferred from sequence model protein binding ; GO:0005515 | inferred from physical interaction with rpr ubiquitin protein ligase binding ; GO:0031625 | inferred from physical interaction with Diap1 "negative regulation of apoptotic process ; GO:0043066 | inferred from direct assay positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria ; GO:0006964 | inferred from mutant phenotype regulation of cysteine-type endopeptidase activity involved in apoptotic process ; GO:0043281 | inferred from mutant phenotype defense response to Gram-negative bacterium ; GO:0050829 | inferred from mutant phenotype negative regulation of apoptotic process ; GO:0043066 | traceable author statement peptidoglycan recognition protein signaling pathway ; GO:0061057 | inferred from mutant phenotype negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ; GO:0043154 | inferred from genetic interaction with Drice sensory organ development ; GO:0007423 | inferred from mutant phenotype protein ubiquitination ; GO:0016567 | inferred from direct assay negative regulation of apoptotic process ; GO:0043066 | inferred from mutant phenotype protein K48-linked ubiquitination ; GO:0070936 | inferred from direct assay positive regulation of protein import into nucleus, translocation ; GO:0033160 | inferred from mutant phenotype protein K63-linked ubiquitination ; GO:0070534 | inferred from direct assay inhibition of cysteine-type endopeptidase activity involved in apoptotic process ; GO:1990001 | inferred from biological aspect of ancestor with PANTHER:PTN000799330 negative regulation of apoptotic process ; GO:0043066 | inferred from sequence or structural similarity regulation of signal transduction ; GO:0009966 | inferred from biological aspect of ancestor with PANTHER:PTN000005165 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process ; GO:0043154 | inferred from direct assay protein ubiquitination involved in ubiquitin-dependent protein catabolic process ; GO:0042787 | inferred from mutant phenotype" nucleus ; GO:0005634 | inferred from biological aspect of ancestor with PANTHER:PTN000799330 perinuclear region of cytoplasm ; GO:0048471 | inferred from direct assay "CG8293, DIAP2, DIAPII, diap2, Diap2, DIAP-2, DIAP, dIAP2, IAP, dIAP, DIHA, D-IAP2, dILP, D-iap2, Ilp, Diha, Diap, IAP2, Iap2, Diap-2" "IPR001370:BIR repeat, IPR001841:Zinc finger, RING-type" CG8293 27-Aug-18 DroID_v2018_08 "Drer\mylipb, Drer\birc7, Drer\birc5b, Drer\birc5a, Drer\birc6, Drer\xiap, Drer\birc2" Scer\BIR1 "Cele\K11D12.9, Cele\bir-1, Cele\bir-2" "Xtro\birc2, Xtro\birc7, Xtro\birc5.2, Xtro\xiap, Xtro\nlrc4, Xtro\birc5.1, Xtro\birc6" "Mmus\Naip2, Mmus\Birc7, Mmus\Nlrc4, Mmus\Naip1, Mmus\Birc6, Mmus\Birc5, Mmus\Xiap, Mmus\Birc2, Mmus\Naip6, Mmus\Naip7, Mmus\Naip5, Mmus\Birc3" "Hsap\NAIP, Hsap\XIAP, Hsap\BIRC8, Hsap\BIRC7, Hsap\BIRC3, Hsap\BIRC5, Hsap\MYLIP, Hsap\NLRC4, Hsap\BIRC2, Hsap\BIRC6" embryonic stage&&larval stage&&adult stage "lethal - all die before end of pupal stage,some die during pupal stage,immune response defective,visible,body color defective,partially lethal - majority die,viable,radiation sensitive,cell death defective,conditional,fertile,increased cell death,chemical sensitive" "macrochaeta,supernumerary,trichogen cell,mesothoracic tergum,wing disc,eye,pigment cell" FBgn0029157 ssh slingshot http://flybase.org/reports/FBgn0029157 protein_coding_gene protein tyrosine phosphatase activity ; GO:0004725 | inferred from electronic annotation with InterPro:IPR016130 actin binding ; GO:0003779 | inferred from biological aspect of ancestor with PANTHER:PTN000016922 phosphoprotein phosphatase activity ; GO:0004721 | inferred from direct assay MAP kinase tyrosine/serine/threonine phosphatase activity ; GO:0017017 | NOT inferred from direct assay protein tyrosine/serine/threonine phosphatase activity ; GO:0008138 | non-traceable author statement actin binding ; GO:0003779 | inferred from direct assay regulation of axonogenesis ; GO:0050770 | inferred from mutant phenotype negative regulation of actin filament polymerization ; GO:0030837 | inferred from direct assay protein dephosphorylation ; GO:0006470 | non-traceable author statement regulation of axonogenesis ; GO:0050770 | inferred from genetic interaction with sick protein dephosphorylation ; GO:0006470 | inferred from mutant phenotype mitotic cell cycle ; GO:0000278 | inferred from mutant phenotype compound eye development ; GO:0048749 | inferred from genetic interaction with mbt regulation of actin polymerization or depolymerization ; GO:0008064 | inferred from mutant phenotype axonogenesis ; GO:0007409 | inferred from mutant phenotype regulation of actin filament polymerization ; GO:0030833 | inferred from mutant phenotype cell morphogenesis ; GO:0000902 | inferred from mutant phenotype establishment of nucleus localization ; GO:0040023 | inferred from mutant phenotype mushroom body development ; GO:0016319 | inferred from mutant phenotype regulation of lamellipodium assembly ; GO:0010591 | inferred from mutant phenotype cytoskeleton ; GO:0005856 | inferred from electronic annotation with InterPro:IPR027232 cytoplasm ; GO:0005737 | inferred from biological aspect of ancestor with PANTHER:PTN000016922 apical part of cell ; GO:0045177 | inferred from direct assay "Ssh, MKP, CG6238, Mkph, l(3)01207, ssh, SSH" "IPR000340:Dual specificity phosphatase, catalytic domain, IPR000387:Tyrosine specific protein phosphatases domain, IPR014876:DEK, C-terminal, IPR016130:Protein-tyrosine phosphatase, active site, IPR020422:Dual specificity protein phosphatase domain, IPR024950:Dual specificity phosphatase, IPR027232:Protein phosphatase Slingshot, IPR029021:Protein-tyrosine phosphatase-like" CG6238 27-Aug-18 DroID_v2018_08 "Drer\si:dkey-175m17.7, Drer\dusp22a, Drer\styx, Drer\dusp2, Drer\dusp19b, Drer\LOC100150565, Drer\dusp13a, Drer\dusp6, Drer\ssh2a, Drer\dusp8b, Drer\dusp16, Drer\dupd1, Drer\dusp14, Drer\si:ch1073-184j22.2, Drer\dusp1, Drer\dusp22b, Drer\dusp7, Drer\dusp4, Drer\dusp3a, Drer\dusp8a, Drer\ssh1b, Drer\ssh2b, Drer\si:ch211-121a2.2, Drer\dusp5, Drer\dusp3b, Drer\dusp10, Drer\si:ch211-195b15.8, Drer\si:ch211-203d1.3, Drer\zgc:153044, Drer\dusp12, Drer\ssh1a, Drer\styxl1, Drer\dusp27, Drer\LOC100538052, Drer\si:ch211-223p8.8, Drer\dusp28, Drer\dusp19a, Drer\zgc:153981" "Scer\YVH1, Scer\MSG5, Scer\SDP1, Scer\PPS1" "Cele\vhp-1, Cele\Y54F10BM.13, Cele\lip-1, Cele\F13D11.3, Cele\C04F12.8, Cele\F26A3.4" "Xtro\dusp10, Xtro\dusp28, Xtro\dusp22, Xtro\dusp6, Xtro\epm2a, Xtro\dupd1, Xtro\dusp4, Xtro\ssh1, Xtro\dusp12, Xtro\styxl1, Xtro\styx, Xtro\dusp9, Xtro\dusp18, Xtro\ssh2, Xtro\dusp26, Xtro\dusp5, Xtro\dusp19, Xtro\dusp1, Xtro\dusp22a" "Mmus\Dusp18, Mmus\Ssh2, Mmus\Dusp10, Mmus\Dusp22, Mmus\Dusp9, Mmus\Dusp28, Mmus\Dupd1, Mmus\Dusp1, Mmus\Dusp12, Mmus\Dusp3, Mmus\Ssh1, Mmus\Dusp16, Mmus\Dusp26, Mmus\Dusp6, Mmus\Ssh3, Mmus\Dusp27, Mmus\Dusp4, Mmus\Dusp8, Mmus\Dusp14, Mmus\Dusp7, Mmus\Epm2a, Mmus\Dusp19, Mmus\Dusp21, Mmus\Dusp2, Mmus\Dusp5, Mmus\Dusp15, Mmus\Styx, Mmus\Styxl1, Mmus\Dusp13" "Hsap\DUSP26, Hsap\DUSP2, Hsap\DUPD1, Hsap\STYX, Hsap\DUSP22, Hsap\EPM2A, Hsap\DUSP7, Hsap\DUSP3, Hsap\DUSP8, Hsap\DUSP5, Hsap\DUSP15, Hsap\DUSP10, Hsap\DUSP9, Hsap\DUSP18, Hsap\DUSP6, Hsap\DUSP1, Hsap\STYXL1, Hsap\DUSP13, Hsap\DUSP4, Hsap\DUSP14, Hsap\DUSP21, Hsap\SSH3, Hsap\DUSP27, Hsap\SSH2, Hsap\DUSP16, Hsap\DUSP19, Hsap\SSH1, Hsap\DUSP12" "lethal,recessive,visible,somatic clone,maternal effect,lethal - all die before end of embryonic stage,some die during embryonic stage,neuroanatomy defective,lethal - all die before end of pupal stage,some die during pupal stage" "denticle belt,embryonic/first instar larval cuticle,eye,somatic clone,maternal effect,ommatidium,rhabdomere,adult mushroom body & axon | somatic clone,medial branch of mushroom body,optic lobe neuron & axon | somatic clone,antennal lobe & axon | somatic clone,vertical lobe of adult mushroom body,filamentous actin & ommatidial cluster | ectopic | somatic clone,nucleus & ommatidial cluster | somatic clone,apical junction complex & ommatidial cluster | somatic clone,wing hair,macrochaeta & mesothoracic tergum | somatic clone,actin filament | cell autonomous | ectopic | somatic clone,filamentous actin | somatic clone,medial lobe of adult mushroom body" DRSC16730 K 0.360154131 0.621323091 -0.0240727 0.206665041 1.815135056 1.285103886 FBgn0001961 Arpc1 "Actin-related protein 2/3 complex, subunit 1" http://flybase.org/reports/FBgn0001961 - protein_coding_gene structural constituent of cytoskeleton ; GO:0005200 | inferred from sequence or structural similarity with HGNC:704 actin binding ; GO:0003779 | inferred from sequence or structural similarity actin filament binding ; GO:0051015 | inferred from biological aspect of ancestor with PANTHER:PTN000076207 cell adhesion mediated by integrin ; GO:0033627 | inferred from mutant phenotype chaeta development ; GO:0022416 | inferred from mutant phenotype actin filament-based process ; GO:0030029 | inferred from mutant phenotype Arp2/3 complex-mediated actin nucleation ; GO:0034314 | inferred from biological aspect of ancestor with PANTHER:PTN000076207 pseudocleavage involved in syncytial blastoderm formation ; GO:0030589 | inferred from mutant phenotype intracellular protein transport ; GO:0006886 | inferred from mutant phenotype axonal fasciculation ; GO:0007413 | inferred from genetic interaction with Arp3 compound eye morphogenesis ; GO:0001745 | inferred from mutant phenotype positive regulation of filopodium assembly ; GO:0051491 | inferred from mutant phenotype epithelium development ; GO:0060429 | inferred from mutant phenotype germarium-derived egg chamber formation ; GO:0007293 | inferred from mutant phenotype chaeta morphogenesis ; GO:0008407 | inferred from mutant phenotype cell morphogenesis ; GO:0000902 | inferred from mutant phenotype positive regulation of Notch signaling pathway ; GO:0045747 | inferred from mutant phenotype cytoskeleton organization ; GO:0007010 | inferred from sequence or structural similarity actin filament reorganization involved in cell cycle ; GO:0030037 | inferred from mutant phenotype axonogenesis ; GO:0007409 | inferred from genetic interaction with Arp3 negative regulation of dendrite morphogenesis ; GO:0050774 | inferred from mutant phenotype Arp2/3 complex-mediated actin nucleation ; GO:0034314 | inferred from sequence or structural similarity with HGNC:704 detection of temperature stimulus involved in sensory perception of pain ; GO:0050965 | inferred from mutant phenotype Arp2/3 protein complex ; GO:0005885 | inferred from sequence or structural similarity with HGNC:704 Arp2/3 protein complex ; GO:0005885 | non-traceable author statement Arp2/3 protein complex ; GO:0005885 | traceable author statement "ArcP41, sop2, Arpc1, ARPC1, l(2)34Dd, ARPC1/p41, Spo2, Dsop2, CG8978, ARC-P41, sop2/arc41, l(2)Sop2, arc41, BG:DS00941.7, p42, 34Dd, br32, l(2)br32, DSop2, Sop2, D-sop2, Arc41, ArpC1, arpc1, sop, p41" "IPR015943:WD40/YVTN repeat-like-containing domain, IPR017986:WD40-repeat-containing domain, IPR001680:WD40 repeat, IPR017383:Actin-related protein 2/3 complex subunit 1" CG8978 27-Aug-18 DroID_v2018_08 "Drer\arpc1b, Drer\arpc1a, Drer\zgc:86896" Scer\ARC40 Cele\arx-3 "Xtro\arpc1a, Xtro\arpc1b" "Mmus\Arpc1b, Mmus\Arpc1a" "Hsap\ARPC1A, Hsap\ARPC1B" oogenesis stage | stage S9 ring canal

"lethal,recessive,visible,partially lethal - majority die,some die during pupal stage" "trichogen cell,supernumerary,mesothoracic tergum,nurse cell,germline clone,follicle cell,somatic clone,epithelium,female germline cyst,filopodium,nurse cell ring canal,actin filament & nurse cell | germ-line clone,nucleus & nurse cell | germ-line clone,tormogen cell,macrochaeta,eye,ommatidium,lens,interommatidial bristle,macrochaeta & adult head | somatic clone,microchaeta & adult head | somatic clone,rhabdomere | adult stage | somatic clone,photoreceptor,retina,cell cycle | germline clone,metaphase & condensed nuclear chromosome | germ-line clone,centrosome | ectopic | germline clone,actin filament | germline clone,oocyte,nucleus | embryonic stage 4 | germline clone | non-rescuable maternal effect,actin filament | embryonic stage 4 | germline clone | non-rescuable maternal effect,nurse cell & actin filament | germ-line clone,anterior dorsocentral bristle,myoblast,mechanosensory chaeta,external sensory organ precursor cell IIa,external sensory organ precursor cell IIb,wing" FBgn0020510 Abi Abelson interacting protein http://flybase.org/reports/FBgn0020510 - protein_coding_gene "protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:B1Q236,UniProtKB:P55162,UniProtKB:Q8MLQ0,UniProtKB:Q9VF87,UniProtKB:Q9VKM2 protein binding ; GO:0005515 | inferred from physical interaction with Abl protein binding ; GO:0005515 | inferred from physical interaction with Ptp61F protein binding ; GO:0005515 | inferred from physical interaction with ena protein binding ; GO:0005515 | inferred from physical interaction with Hem inferred from physical interaction with WASp" regulation of actin cytoskeleton organization ; GO:0032956 | inferred from mutant phenotype photoreceptor cell axon guidance ; GO:0072499 | inferred from mutant phenotype actin cytoskeleton organization ; GO:0030036 | inferred from mutant phenotype Golgi organization ; GO:0007030 | inferred from mutant phenotype axon extension involved in axon guidance ; GO:0048846 | inferred from mutant phenotype muscle attachment ; GO:0016203 | inferred from mutant phenotype cell adhesion ; GO:0007155 | inferred from mutant phenotype neuromuscular junction development ; GO:0007528 | inferred from genetic interaction with Abl phagocytosis ; GO:0006909 | inferred from mutant phenotype positive regulation of protein kinase activity ; GO:0045860 | inferred from direct assay cell adhesion mediated by integrin ; GO:0033627 | inferred from mutant phenotype positive regulation of cytoskeleton organization ; GO:0051495 | inferred from mutant phenotype cortical actin cytoskeleton organization ; GO:0030866 | inferred from mutant phenotype lamellipodium assembly ; GO:0030032 | inferred from mutant phenotype cell projection assembly ; GO:0030031 | inferred from mutant phenotype oogenesis ; GO:0048477 | inferred from mutant phenotype chaeta development ; GO:0022416 | inferred from mutant phenotype cell morphogenesis ; GO:0000902 | inferred from mutant phenotype central nervous system neuron axonogenesis ; GO:0021955 | inferred from mutant phenotype regulation of cell shape ; GO:0008360 | inferred from mutant phenotype "SCAR complex ; GO:0031209 | inferred from direct assay lamellipodium membrane ; GO:0031258 | inferred from direct assay protein complex ; GO:0043234 | colocalizes_with inferred from physical interaction with WASp basal part of cell ; GO:0045178 | inferred from direct assay perinuclear region of cytoplasm ; GO:0048471 | inferred from direct assay SCAR complex ; GO:0031209 | colocalizes_with inferred from physical interaction with Hem, SCAR" "dAbi, Abi-1, CG9749, Ablphilin, Abi, abi" "IPR001452:SH3 domain, IPR012849:Abl-interactor, homeo-domain homologous domain, IPR028457:ABI family" CG9749 27-Aug-18 DroID_v2018_08 "Drer\abi3a, Drer\abi1b, Drer\abi2a, Drer\abi3b, Drer\abi2b, Drer\abi1a" - "Cele\abi-1, Cele\nck-1" "Xtro\abi2, Xtro\abi1" "Mmus\Abi3, Mmus\Abi2, Mmus\Abi1" "Hsap\ABI2, Hsap\ABI3, Hsap\ABI1" "neuroanatomy defective,recessive,lethal - all die before end of P-stage,some die during P-stage,visible,maternal effect,lethal - all die before end of pupal stage,some die during pupal stage,lethal,lethal - all die before end of embryonic stage,germline clone,some die during embryonic stage,cell shape defective,viable" "outer photoreceptor cell,tract,lamina,medulla,photoreceptor cell R2,photoreceptor cell R3,photoreceptor cell R4,photoreceptor cell R5,somatic clone,dorsocentral bristle,scutellar bristle,chaeta,sensory mother cell,longitudinal connective,maternal effect,filamentous actin | ectopicen-e16E,notopleural bristle,supernumerary,chaeta & mesothoracic tergum | ectopic-537.4,presumptive embryonic/larval nervous system" DRSC14099 K -0.025477939 -0.365066553 -0.494653164 -0.285618757 1.813661836 0.138283321 FBgn0020416 Idgf1 Imaginal disc growth factor 1 http://flybase.org/reports/FBgn0020416 FBgn0027915 protein_coding_gene chitin binding ; GO:0008061 | inferred from electronic annotation with InterPro:IPR011583 imaginal disc growth factor receptor binding ; GO:0008084 | inferred from direct assay "carbohydrate metabolic process ; GO:0005975 | inferred from electronic annotation with InterPro:IPR001223, InterPro:IPR013781 chitin-based cuticle development ; GO:0040003 | inferred from mutant phenotype imaginal disc development ; GO:0007444 | inferred from direct assay wound healing ; GO:0042060 | inferred from mutant phenotype ecdysis, chitin-based cuticle ; GO:0018990 | inferred from mutant phenotype" extracellular region ; GO:0005576 | non-traceable author statement "IDGF, IDGF1, IDGF-1, CG4472, idgf1, BG:DS02780.5, Idgf1, ldgf1, DmIDGF1" "IPR001223:Glycoside hydrolase family 18, catalytic domain, IPR011583:Chitinase II, IPR017853:Glycoside hydrolase superfamily, IPR029070:Chitinase insertion domain" CG4472 27-Aug-18 DroID_v2018_08 "Drer\chia.5, Drer\ovgp1, Drer\chia.4, Drer\chia.6, Drer\si:ch211-226m16.2, Drer\chia.3, Drer\chia.2" Scer\CTS2 "Cele\cht-2, Cele\chil-23, Cele\chil-12, Cele\chil-4, Cele\chil-22, Cele\chil-13, Cele\T19H5.6, Cele\chil-25, Cele\chil-3, Cele\chil-2, Cele\chil-7, Cele\chil-15, Cele\lmd-5, Cele\chil-6, Cele\chil-5, Cele\chil-20, Cele\chil-18, Cele\chil-8, Cele\chil-16, Cele\chil-17, Cele\chil-24, Cele\chil-19, Cele\chil-11, Cele\lmd-4" "Xtro\ctbs, Xtro\chia, Xtro\LOC548945, Xtro\chit1" "Mmus\Chil1, Mmus\Chil6, Mmus\Ovgp1, Mmus\Chil3, Mmus\Chil5, Mmus\Chit1, Mmus\Chia1, Mmus\Chil4, Mmus\Ctbs" "Hsap\CHIT1, Hsap\CHIA, Hsap\OVGP1, Hsap\CHI3L1, Hsap\CHI3L2" " embryonic stage , larval stage | third instar , adult stage && oogenesis stage , embryonic stage && larval stage , embryonic stage&&larval stage " " yolk

, larval brain

, imaginal disc

, oocyte

, ventral furrow | vicinity of

, amnioproctodeal invagination | vicinity of

, nurse cell

, ring gland

, cephalic furrow | vicinity of

, larval optic lobe

, lymph gland

, embryonic/larval tracheal system

, embryonic/larval salivary gland

, embryonic/larval fat body

" viable DRSC03349 E -0.39789249 0.113950392 -1.664635496 0.59493807 -0.16923865 -0.150656505 FBgn0003888 betaTub60D beta-Tubulin at 60D http://flybase.org/reports/FBgn0003888 - protein_coding_gene "GTP binding ; GO:0005525 | inferred from electronic annotation with InterPro:IPR002453, InterPro:IPR008280, InterPro:IPR017975 GTPase activity ; GO:0003924 | inferred from electronic annotation with InterPro:IPR003008, InterPro:IPR008280 structural constituent of cytoskeleton ; GO:0005200 | inferred from sequence or structural similarity structural constituent of cytoskeleton ; GO:0005200 | inferred from direct assay" "microtubule-based process ; GO:0007017 | inferred from electronic annotation with InterPro:IPR000217, InterPro:IPR002453, InterPro:IPR017975 response to light stimulus ; GO:0009416 | inferred from mutant phenotype heart development ; GO:0007507 | non-traceable author statement neurogenesis ; GO:0022008 | inferred from mutant phenotype microtubule-based process ; GO:0007017 | inferred from sequence or structural similarity larval behavior ; GO:0030537 | inferred from mutant phenotype axon guidance ; GO:0007411 | inferred from mutant phenotype axonogenesis ; GO:0007409 | inferred from mutant phenotype" microtubule ; GO:0005874 | inferred from direct assay microtubule ; GO:0005874 | inferred from sequence or structural similarity "Tub60D, CG3401, betaTub60D, 143391_i_at, beta-tub, beta3 TU, beta-Tub6D, p50/tubulin, p53/tubulin, p50, p53, beta3, BETA 60D, D.m.BETA-60D, B3t, beta3-Tub, beta[[3]]-Tub, Dmbeta3, betaTub60C, T, beta3t, beta[[3]] tubulin, 3t, DTB3, beta[[3]]-tubulin, beta60C, betaTub3, beta-Tub60D, Tub, beta3Tub, betaTub, betatub60D, beta3-tubulin, beta3TUB, beta3tub, Tub2E, tubulin" "IPR000217:Tubulin, IPR002453:Beta tubulin, IPR003008:Tubulin/FtsZ, GTPase domain, IPR008280:Tubulin/FtsZ, C-terminal, IPR017975:Tubulin, conserved site, IPR018316:Tubulin/FtsZ, 2-layer sandwich domain, IPR013838:Beta tubulin, autoregulation binding site" CG3401 27-Aug-18 DroID_v2018_08 "Drer\tubb6, Drer\tubb2b, Drer\zgc:153426, Drer\zgc:153264, Drer\zgc:65894, Drer\tubb2, Drer\tubb1, Drer\tubb5, Drer\zgc:55461, Drer\tubb4b" Scer\TUB2 "Cele\tbb-2, Cele\tbb-1, Cele\ben-1, Cele\tbb-4, Cele\mec-7" "Xtro\tubb4b, Xtro\tube1, Xtro\tubb2b, Xtro\tubb6, Xtro\tubb4a, Xtro\tubb3, Xtro\tubb" "Mmus\Tubb4a, Mmus\Tubb1, Mmus\Tubb3, Mmus\Tubb2a, Mmus\Tubb5, Mmus\Tubb2b, Mmus\Tubb4b, Mmus\Tubb6, Mmus\Tube1" "Hsap\TUBB6, Hsap\TUBB3, Hsap\TUBB8, Hsap\TUBB4B, Hsap\TUBB4A, Hsap\TUBB1, Hsap\TUBB2B, Hsap\TUBE1, Hsap\TUBB, Hsap\TUBB2A" " embryonic stage | stage 13 , embryonic stage | 0-10 hr , prepupal stage , larval stage | third instar , pupal stage | mid , oogenesis stage && adult stage | female , embryonic stage | stage 12 , embryonic stage | 9-15 hr , pupal stage , oogenesis stage && pupal stage , embryonic stage | stage 14 , embryonic stage | >=stage 11 , embryonic stage | stage 10 , adult stage | male , pupal stage | mid-late " " visceral mesoderm

, ventral metathoracic disc

, indirect flight muscle

, follicle cell

, mesoderm

, ovary

, head mesoderm

, dorsal metathoracic disc

, dorsal mesothoracic disc

, optic lobe | presumptive

, somatic mesoderm

, adult brain | presumptive

, testis | cyst cell

, muscle system

, eye-antennal disc

, testis

, ventral mesothoracic disc

, ventral prothoracic disc

" embryonic stage | stage 17 mesoderm | posterior | segmentally repeated pattern

"viable,sterile,lethal - all die before end of P-stage,some die during pharate adult stage,lethal,recessive,partially lethal - majority die,male fertile,fertile,flightless,phototaxis defective,lethal - all die before end of larval stage,some die during larval stage,partially lethal - majority live,visible,male sterile,neuroanatomy defective,some die during pupal stage,locomotor behavior defective" "axoneme,meiotic cell cycle | male,embryonic/larval midgut,chordotonal organ & microtubulePx2),optic lobe,eye,lamina,medulla & axon,photoreceptor cell R8 & axon,photoreceptor cell R7 & axon,rhabdomere,embryonic/larval neuroblast,ganglion mother cell,trichogen cell,tormogen cell,mesothoracic tergum" FBgn0001297 kay kayak http://flybase.org/reports/FBgn0001297 "FBgn0053956, FBgn0000468, FBgn0000725, FBgn0003506, FBgn0039693, FBtr0085478, FBpp0084844, FBtr0085479, FBpp0084845, FBtr0085480, FBpp0084846" protein_coding_gene "transcription factor binding ; GO:0008134 | traceable author statement DNA binding ; GO:0003677 | inferred from direct assay protein binding ; GO:0005515 | inferred from physical interaction with HDAC1 inferred from physical interaction with chm repressing transcription factor binding ; GO:0070491 | inferred from physical interaction with vri transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ; GO:0001077 | inferred from direct assay protein heterodimerization activity ; GO:0046982 | inferred from sequence or structural similarity RNA polymerase II transcription factor activity, sequence-specific DNA binding ; GO:0000981 | inferred from direct assay sequence-specific DNA binding ; GO:0043565 | inferred from direct assay protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with Jra protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:P18289 transcription factor activity, sequence-specific DNA binding ; GO:0003700 | traceable author statement protein binding ; GO:0005515 | inferred from physical interaction with Cka" "positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 | inferred from direct assay JNK cascade ; GO:0007254 | non-traceable author statement adult chitin-containing cuticle pigmentation ; GO:0048085 | inferred from mutant phenotype establishment of planar polarity ; GO:0001736 | non-traceable author statement synaptic growth at neuromuscular junction ; GO:0051124 | inferred from genetic interaction with Jra wing disc development ; GO:0035220 | inferred from mutant phenotype second mitotic wave involved in compound eye morphogenesis ; GO:0016330 | inferred from mutant phenotype locomotor rhythm ; GO:0045475 | inferred from mutant phenotype dendrite morphogenesis ; GO:0048813 | inferred from mutant phenotype wound healing ; GO:0042060 | inferred from mutant phenotype R3/R4 cell fate commitment ; GO:0007464 | traceable author statement ovarian follicle cell migration ; GO:0007297 | inferred from mutant phenotype dorsal closure ; GO:0007391 | inferred from mutant phenotype embryo development ; GO:0009790 | inferred from mutant phenotype dorsal closure ; GO:0007391 | traceable author statement response to wounding ; GO:0009611 | inferred from mutant phenotype R3/R4 cell fate commitment ; GO:0007464 | inferred from mutant phenotype antimicrobial humoral response ; GO:0019730 | inferred from mutant phenotype imaginal disc fusion, thorax closure ; GO:0046529 | inferred from mutant phenotype compound eye development ; GO:0048749 | inferred from mutant phenotype germ cell development ; GO:0007281 | inferred from mutant phenotype imaginal disc fusion, thorax closure ; GO:0046529 | traceable author statement border follicle cell migration ; GO:0007298 | inferred from genetic interaction with Pvr dorsal closure ; GO:0007391 | non-traceable author statement collateral sprouting of injured axon ; GO:0048674 | inferred from mutant phenotype regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle ; GO:0031660 | inferred from mutant phenotype" cytoplasm ; GO:0005737 | inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay transcription factor complex ; GO:0005667 | inferred from physical interaction with Jra "CG15509, CG15507, DFos, AP-1, Dfos, DFOS, D-fos, D-Fos, fos, Fos, AP1, d-fos, c-Fos, dFRA, dFos, Fra, DFra, dFra, dAP-1, kay, D-fos/kay, CG33956, Kay, dfos, c-fos, fbz, dlhD, fra, KAY, FOS, DM30, DM3" "IPR000837:AP-1 transcription factor, IPR004827:Basic-leucine zipper domain" CG33956 27-Aug-18 DroID_v2018_08 "Drer\atf1, Drer\fosab, Drer\batf, Drer\batf3, Drer\si:ch211-153j24.3, Drer\fosl1a, Drer\si:ch211-59d15.4, Drer\fosaa, Drer\atf7a, Drer\jdp2a, Drer\fosl1b, Drer\atf2, Drer\creb1a, Drer\fosl2, Drer\atf3, Drer\atf7b, Drer\creb5b, Drer\jdp2b, Drer\fosb, Drer\crema" "Scer\ACA1, Scer\CST6, Scer\SKO1" "Cele\fos-1, Cele\zip-11, Cele\crh-1" "Xtro\atf7, Xtro\atf3, Xtro\fosl2, Xtro\atf1, Xtro\batf, Xtro\creb5, Xtro\fos, Xtro\fosl1, Xtro\atf2, Xtro\fosb" "Mmus\Fos, Mmus\Atf1, Mmus\Atf7, Mmus\Atf3, Mmus\Batf3, Mmus\Fosl1, Mmus\Batf, Mmus\Creb5, Mmus\Atf2, Mmus\Batf2, Mmus\Jdp2, Mmus\Fosl2, Mmus\Fosb, Mmus\Creb1" "Hsap\ATF1, Hsap\FOS, Hsap\CREM, Hsap\BATF, Hsap\ATF2, Hsap\FOSL1, Hsap\JDP2, Hsap\CREB1, Hsap\ATF7, Hsap\FOSL2, Hsap\CREB5, Hsap\ATF3, Hsap\FOSB, Hsap\BATF3, Hsap\BATF2" " embryonic stage | stage 15 , embryonic stage , embryonic stage | 4-8 hr " " eo neuron

, dorsal ectoderm

, embryonic/larval midgut

, muscle attachment site

, amnioserosa

, embryonic/larval hindgut

, anal pad

, multidendritic neuron

, embryonic peripheral nervous system | restricted

, head | restricted

" "neuroanatomy defective,locomotor rhythm defective,viable,fertile,planar polarity defective,somatic clone,lethal - all die before end of embryonic stage,recessive,some die during embryonic stage,visible,wild-type,lethal,wound healing defective,cell lethalcell lethal,heat sensitive,neurophysiology defective,conditional,partially,partially lethal - majority live,lethal - all die before end of pupal stage,some die during pupal stage,mitotic cell cycle defective,increased cell death,developmental rate defective,long lived,male limited,starvation stress response defective,temperature response defective,gravitaxis defective" "Kenyon cell,axoney-OK107,dorsal multidendritic neuron ddaD,dorsal multidendritic neuron ddaE,dorsal multidendritic neuron ddaC,abdominal anterior ventral multidendritic neuron vdaa,ventral multidendritic neuron vdaB,ommatidium,photoreceptor cell R4,somatic clone,embryonic/larval hemocyte | third instar larval stage,dendrite,RP2 motor neuron,eye photoreceptor cell,egg,maternal effect,dorsal appendage,nurse cell & nucleus | somatic clone,stage S14 oocyte,adult thorax,dorsal,mesothoracic cleft,embryonic dorsal epidermis,dorsal closure embryo,embryonic epidermis,embryonic head,embryo,wing disc,wing,embryonic ventral epidermis,follicle cell,stage S9 oocyte,embryonic/first instar larval cuticle,wing vein L3,wing vein L5,wing vein,heart primordium,scutellum,imaginal disc,pupal thorax,salivary gland,eye,cuprophilic cell,midgut interstitial cell,adult midgut precursor cell,bouton,neuromuscular junction | larval stage,terminal bouton,synapse,anterior crossvein,wing vein L2,wing vein L4,neuromuscular junctionBG380,segmental nerve,conditional,dendrite | somatic cloneFLP1UAS.cUa, Act.PU, eve.RRK,motor neuron,thorax,pigment cell,trichogen cell,mesothoracic tergum,adult heart,RU486 conditional,posterior" DRSC16977 IE 3.022447147 4.211683207 2.840500332 1.748045363 -0.463202103 -0.167621605 FBgn0038167 Lkb1 Lkb1 kinase http://flybase.org/reports/FBgn0038167 protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 protein serine/threonine kinase activity ; GO:0004674 | inferred from biological aspect of ancestor with PANTHER:PTN000680267 protein kinase activator activity ; GO:0030295 | inferred from biological aspect of ancestor with PANTHER:PTN001552748 protein serine/threonine kinase activity ; GO:0004674 | inferred from sequence or structural similarity with HGNC:11389 protein kinase activity ; GO:0004672 | non-traceable author statement" "peptidyl-threonine phosphorylation ; GO:0018107 | inferred from biological aspect of ancestor with PANTHER:PTN000680267 protein phosphorylation ; GO:0006468 | non-traceable author statement protein phosphorylation ; GO:0006468 | inferred from sequence or structural similarity with HGNC:11389 positive regulation of protein serine/threonine kinase activity ; GO:0071902 | inferred from biological aspect of ancestor with PANTHER:PTN001552748 border follicle cell delamination ; GO:0030709 | inferred from mutant phenotype mitotic spindle organization ; GO:0007052 | inferred from mutant phenotype protein phosphorylation ; GO:0006468 | inferred from mutant phenotype dorsal closure ; GO:0007391 | inferred from mutant phenotype peptidyl-serine phosphorylation ; GO:0018105 | inferred from biological aspect of ancestor with PANTHER:PTN000680267 pole plasm oskar mRNA localization ; GO:0045451 | inferred from mutant phenotype asymmetric neuroblast division ; GO:0055059 | inferred from mutant phenotype protein localization to cell cortex ; GO:0072697 | inferred from mutant phenotype inferred from genetic interaction with mira, fray maintenance of neuroblast polarity ; GO:0045201 | inferred from direct assay determination of adult lifespan ; GO:0008340 | inferred from direct assay establishment or maintenance of cell polarity ; GO:0007163 | non-traceable author statement regulation of JNK cascade ; GO:0046328 | inferred from direct assay oocyte microtubule cytoskeleton organization ; GO:0016325 | inferred from mutant phenotype positive regulation of apoptotic process ; GO:0043065 | inferred from direct assay" nucleus ; GO:0005634 | inferred from direct assay cell cortex ; GO:0005938 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay "lkb1, LKB1, Lkb1, dLKB1, DmLKB1, PAR-4, CG9374, LKB1/PEUTZ JEGHERS KINASE, STK11, par-4, anon-EST:Posey135, PAR4, dlkb1" "IPR000719:Protein kinase domain, IPR008271:Serine/threonine-protein kinase, active site, IPR011009:Protein kinase-like domain, IPR017441:Protein kinase, ATP binding site, IPR020636:Calcium/calmodulin-dependent/calcium-dependent protein kinase" CG9374 27-Aug-18 DroID_v2018_08 Drer\stk11 "Scer\SAK1, Scer\TOS3" Cele\par-4 Xtro\stk11 Mmus\Stk11 Hsap\STK11 "hyperplasia,long lived,female limited,heat sensitive,cell polarity defective,mitotic cell cycle defective,decreased cell death,lethal - all die before end of pupal stage,some die during pupal stage,increased cell death,lethal,recessive,germline clone,maternal effect,cell cycle defective,cytokinesis defective" "wing,eye,embryonic/larval brain,ventral nerve cord,wing disc,wing blade,follicle cell,oocyte,germline clone,oocyte & microtubule | germ-line clone,border follicle cell,somatic clone,neuroblast,spindle,centrosome,brain,aster,kinetochore microtubule,spindle microtubule,spindleurd),asterurd),kinetochore microtubuleurd),spindle microtubuleurd),spindle & larval neuroblasturd),embryonic/larval neuroblast,centrosome & larval neuroblasturd),scutellum,adult thoracic sensillum" FBgn0015858 anon-14Ab anon-14Ab http://flybase.org/reports/FBgn0015858 - gene - - - "td28, anon-14Ab" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0026181 Rok Rho kinase http://flybase.org/reports/FBgn0026181 FBgn0028698 protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290, InterPro:IPR017441 Rho GTPase binding ; GO:0017048 | inferred from electronic annotation with InterPro:IPR015008 protein serine/threonine kinase activity ; GO:0004674 | non-traceable author statement GTPase binding ; GO:0051020 | inferred from physical interaction with Rho1 protein serine/threonine kinase activity ; GO:0004674 | inferred from direct assay protein binding ; GO:0005515 | inferred from physical interaction with Rho1 protein serine/threonine kinase activity ; GO:0004674 | inferred from sequence or structural similarity inferred from direct assay" regulation of phosphorylation ; GO:0042325 | inferred from direct assay epidermis development ; GO:0008544 | inferred from mutant phenotype protein phosphorylation ; GO:0006468 | non-traceable author statement dorsal closure ; GO:0007391 | traceable author statement regulation of axonogenesis ; GO:0050770 | inferred from genetic interaction with LIMK1 actin cytoskeleton reorganization ; GO:0031532 | inferred from mutant phenotype morphogenesis of embryonic epithelium ; GO:0016331 | inferred from mutant phenotype regulation of planar cell polarity pathway involved in axis elongation ; GO:2000040 | inferred from direct assay establishment of ommatidial planar polarity ; GO:0042067 | inferred from mutant phenotype Rho protein signal transduction ; GO:0007266 | inferred from physical interaction with Rho1 regulation of cell shape ; GO:0008360 | inferred from mutant phenotype establishment of planar polarity ; GO:0001736 | traceable author statement imaginal disc-derived wing hair organization ; GO:0035317 | inferred from mutant phenotype inferred from genetic interaction with dsh inferred from genetic interaction with fz actin cytoskeleton organization ; GO:0030036 | inferred from mutant phenotype nuclear axial expansion ; GO:0035191 | inferred from mutant phenotype regulation of actin cytoskeleton organization ; GO:0032956 | inferred from mutant phenotype cortical protein anchoring ; GO:0032065 | inferred from mutant phenotype positive regulation of stress fiber assembly ; GO:0051496 | inferred from genetic interaction with Fhos female germline ring canal stabilization ; GO:0008335 | inferred from mutant phenotype regulation of protein phosphorylation ; GO:0001932 | inferred from mutant phenotype mitotic cytokinesis ; GO:0000281 | inferred from mutant phenotype oocyte development ; GO:0048599 | inferred from mutant phenotype apical constriction involved in gastrulation ; GO:0003384 | inferred from mutant phenotype oocyte axis specification ; GO:0007309 | inferred from mutant phenotype establishment of imaginal disc-derived wing hair orientation ; GO:0001737 | inferred from mutant phenotype nurse cell nucleus anchoring ; GO:0007302 | inferred from mutant phenotype regulation of actin filament bundle assembly ; GO:0032231 | inferred from mutant phenotype inferred from genetic interaction with dsh inferred from genetic interaction with fz mitotic cytokinesis ; GO:0000281 | inferred from direct assay positive regulation of wound healing ; GO:0090303 | inferred from mutant phenotype negative regulation of response to wounding ; GO:1903035 | inferred from mutant phenotype regulation of cell junction assembly ; GO:1901888 | inferred from genetic interaction with Pten establishment of protein localization ; GO:0045184 | inferred from mutant phenotype mitotic nuclear division ; GO:0007067 | inferred from mutant phenotype mitotic spindle elongation ; GO:0000022 | inferred from mutant phenotype regulation of myoblast fusion ; GO:1901739 | inferred from genetic interaction with Rho1 ovarian nurse cell to oocyte transport ; GO:0007300 | inferred from mutant phenotype ommatidial rotation ; GO:0016318 | non-traceable author statement apical cortex ; GO:0045179 | colocalizes_with inferred from direct assay cell-cell contact zone ; GO:0044291 | inferred from direct assay "ROCK, Drok, Rok, DROK, ROK, ROKalpha/beta, drok, Rock, RhoK, dROK, dRok, DRhk, ROCK1, CG9774, Rhk, ROCK-1, rok, DRok, Rok/ROCK, ROCK2" "IPR029875:Rho-associated protein kinase LET-502, IPR000719:Protein kinase domain, IPR000961:AGC-kinase, C-terminal, IPR001849:Pleckstrin homology domain, IPR002219:Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, IPR008271:Serine/threonine-protein kinase, active site, IPR011009:Protein kinase-like domain, IPR015008:Rho binding domain, IPR017441:Protein kinase, ATP binding site, IPR011993:PH domain-like, IPR020684:Rho-associated protein kinase 1/2" CG9774 27-Aug-18 DroID_v2018_08 "Drer\LOC101882847, Drer\rock1, Drer\rock2b, Drer\rock2a, Drer\cdc42bpb" "Scer\HSL1, Scer\CBK1" Cele\let-502 "Xtro\rock2, Xtro\rock1, Xtro\tacc3" "Mmus\Rock2, Mmus\Tacc3, Mmus\Rock1, Mmus\Cdc42bpb, Mmus\Tacc2" "Hsap\ROCK2, Hsap\CDC42BPB, Hsap\TACC3, Hsap\ROCK1" " embryonic stage , larval stage | third instar " "

ubiquitous , imaginal disc | ubiquitous

" "lethal - all die before end of pupal stage,visible,planar polarity defective,partially lethal - majority die,some die during pupal stage,wound healing defective,mitotic cell cycle defective,neuroanatomy defective,cell polarity defective,somatic clone,cell shape defective,increased cell death,wild-type,lethal,viable,recessive,female sterile,germline clone,axis specification defective,male limited,lethal - all die before end of larval stage,some die during larval stage,lethal - all die before end of embryonic stage,some die during embryonic stage" "presumptive embryonic salivary gland,egg chamber,conditional,wing,mesothoracic tergum,S2 cell-line & spindle,S2 cell-line & cell,S2 cell-line & spindle microtubule,S2 cell-line & polar microtubule,embryonic/larval epidermis,oocyte,somatic clone,vertical lobe of adult mushroom body,nucleus,epithelial cell,eye,photoreceptor cell,crossvein,wing margin,macrophage | third instar larval stage,stress fiber | third instar larval stageHml.ëÓ,contractile ring | somatic clone,eye photoreceptor cell,supernumerary,ommatidium,wing hair,cell autonomous,mushroom body & axon | somatic clone,egg,germline clone,dorsal appendage,yolk granule | germline clone,nurse cell,nurse cell ring canal,filamentous actin & oocyte | germ-line clone,filamentous actin & nurse cell | germ-line clone,plasma membrane & oocyte | germ-line clone,hub cell,adherens junction | somatic clone,morphogenetic furrow,epithelium,follicle cell,anterior embryonic/larval midgut,male limited,embryonic proventriculus,embryonic/first instar larval cuticle,dorsal,dorsal hair,embryonic leading edge cell,wing disc | third instar larval stage,wing disc,somatic clone | third instar larval stage" DRSC20277 K 1.140488567 -0.484681497 -0.401458467 0.182061105 -0.607747052 -1.512870256 FBgn0000547 ed echinoid http://flybase.org/reports/FBgn0000547 "FBgn0022256, FBgn0031582, FBgn0031583, FBgn0031584" protein_coding_gene protein binding ; GO:0005515 | inferred from physical interaction with Grip "negative regulation of neurogenesis ; GO:0050768 | inferred from mutant phenotype dorsal closure ; GO:0007391 | inferred from mutant phenotype negative regulation of hippo signaling ; GO:0035331 | inferred from genetic interaction with yki inferred from genetic interaction with sav ommatidial rotation ; GO:0016318 | inferred from mutant phenotype inferred from genetic interaction with fz inferred from genetic interaction with pnt inferred from genetic interaction with stan inferred from genetic interaction with cno muscle organ morphogenesis ; GO:0048644 | inferred from mutant phenotype negative regulation of epidermal growth factor receptor signaling pathway ; GO:0042059 | non-traceable author statement imaginal disc-derived wing morphogenesis ; GO:0007476 | inferred from mutant phenotype negative regulation of organ growth ; GO:0046621 | inferred from mutant phenotype mushroom body development ; GO:0016319 | inferred from mutant phenotype regulation of hippo signaling ; GO:0035330 | inferred from physical interaction with ex inferred from physical interaction with sav inferred from physical interaction with Mer inferred from physical interaction with kibra homophilic cell adhesion via plasma membrane adhesion molecules ; GO:0007156 | inferred from direct assay inferred from mutant phenotype morphogenesis of an epithelium ; GO:0002009 | inferred from mutant phenotype cuticle development ; GO:0042335 | inferred from genetic interaction with UniProtKB:Q0KHR3,UniProtKB:Q9VX75,UniProtKB:X2JCB3,UniProtKB:X2JFU8 lateral inhibition ; GO:0046331 | inferred from mutant phenotype regulation of cell shape ; GO:0008360 | inferred from mutant phenotype regulation of actin cytoskeleton organization by cell-cell adhesion ; GO:0090138 | inferred from mutant phenotype single organismal cell-cell adhesion ; GO:0016337 | inferred from mutant phenotype negative regulation of epidermal growth factor receptor signaling pathway ; GO:0042059 | inferred from mutant phenotype inferred from genetic interaction with Ras85D inferred from genetic interaction with rl inferred from genetic interaction with Egfr inferred from genetic interaction with RasGAP1 inferred from genetic interaction with aos inferred from genetic interaction with rho inferred from genetic interaction with sty branch fusion, open tracheal system ; GO:0035147 | inferred from mutant phenotype regulation of actin cytoskeleton organization ; GO:0032956 | inferred from mutant phenotype sensory organ development ; GO:0007423 | inferred from mutant phenotype inter-male aggressive behavior ; GO:0002121 | inferred from mutant phenotype negative regulation of fusion cell fate specification ; GO:0035157 | inferred from mutant phenotype contractile actin filament bundle assembly ; GO:0030038 | inferred from mutant phenotype wound healing ; GO:0042060 | inferred from mutant phenotype dorsal appendage formation ; GO:0046843 | inferred from mutant phenotype epidermal growth factor receptor signaling pathway ; GO:0007173 | inferred from mutant phenotype inferred from physical interaction with Nrg" cell-cell adherens junction ; GO:0005913 | inferred from direct assay cell cortex ; GO:0005938 | inferred from direct assay adherens junction ; GO:0005912 | inferred from direct assay plasma membrane ; GO:0005886 | inferred from direct assay integral component of membrane ; GO:0016021 | inferred from sequence model "ed, CG16842, E(Elp)[24D], CT13476, CT35484, l(2)k01102, 1X5, E(Elp)24D, CG15424, CG12676, Ed" "IPR003598:Immunoglobulin subtype 2, IPR003599:Immunoglobulin subtype, IPR003961:Fibronectin type III, IPR007110:Immunoglobulin-like domain, IPR013162:CD80-like, immunoglobulin C2-set, IPR013783:Immunoglobulin-like fold" CG12676 27-Aug-18 DroID_v2018_08 "Drer\kirrel3b, Drer\kirrela, Drer\kirrel3l, Drer\kirrel3a, Drer\tmigd1, Drer\kirrelb" - "Cele\igcm-1, Cele\F22D3.6" - "Mmus\Kirrel2, Mmus\Malt1, Mmus\Kirrel3, Mmus\Kirrel" "Hsap\KIRREL2, Hsap\KIRREL, Hsap\MALT1, Hsap\KIRREL3" "lethal,recessive,behavior defective,cell shape defective,cell autonomous,somatic clone,neuroanatomy defective,lethal - all die before end of embryonic stage,some die during embryonic stage,heat sensitive,partially lethal - majority die,some die during pupal stage,lethal - all die before end of pupal stage,visible,dominant,lethal - all die before end of larval stage,some die during larval stage,wild-type,viable,size defective,cell non-autonomous,wound healing defective,germline clone,cell adhesion defective" "embryonic/larval tracheal system,germline clone,rescuable maternal effect,embryo,embryonic epidermis,embryonic/larval dorsal trunk,embryonic/larval lateral trunk,tracheal fusion cell,ectopic,wing disc,cell autonomous,somatic clone,cell non-autonomous,presumptive embryonic/larval central nervous system,embryonic neuroblast,embryonic/larval neuron,supernumerary,ventral nerve cord,macrochaeta,microchaeta,eye,wing vein L2,wing margin,distal,dorsocentral bristle,scutellar bristle,chemosensory ventral triple row & microchaeta | ectopic,dorsal triple row & microchaeta | ectopic,photoreceptor cell R8,sex comb,photoreceptor cell R7,wing,ommatidium,ommatidial precursor cluster,actomyosin | dorsal closure stagec381,epidermal cell | dorsal closure stage,eye photoreceptor cell,dorsal triple row & macrochaeta | ectopic,adult thorax & microchaeta | ectopic,embryonic/first instar larval cuticle,denticle belt,chorion | somatic clone,follicle cell,dorsal closure embryo,actin filament bundle | ectopic | somatic clone,adherens junction | somatic clone,embryonic leading edge cell & actomyosin,embryonic dorsal epidermis,embryonic segment,sensory mother cell,photoreceptor cell R1,photoreceptor cell R2,photoreceptor cell R3,photoreceptor cell R4,photoreceptor cell R5,photoreceptor cell R6,mystery cell,cone cell,wing vein,ventral longitudinal muscle,lateral transverse muscle,photoreceptor cell,apical plasma membrane & cell & dorsal mesothoracic disc & third instar larva | somatic clone,wing hair,wing cell,sensillum campaniformium & wing | supernumerary | somatic clone,oocyte,scutellum,dorsal appendage,actomyosin | dorsal closure stage,embryonic/larval dorsal anastomosis,posterior,chaeta,trichogen cell,mesothoracic tergum" DRSC00439 E -1.109723912 0.005681429 0.031203273 2.062307314 0.549157922 0.554889436 FBgn0030600 hiw highwire http://flybase.org/reports/FBgn0030600 protein_coding_gene zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR001841 protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:O62609 protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q9V6L9 protein binding ; GO:0005515 | inferred from physical interaction with Rae1 inferred from physical interaction with Fsn zinc ion binding ; GO:0008270 | inferred from sequence model ubiquitin-protein transferase activity ; GO:0004842 | inferred from sequence or structural similarity with UniProtKB:Q8WY64 regulation of synaptic growth at neuromuscular junction ; GO:0008582 | traceable author statement negative regulation of BMP signaling pathway ; GO:0030514 | inferred from genetic interaction with UniProtKB:O62609 inferred from genetic interaction with UniProtKB:Q9VZI9 response to axon injury ; GO:0048678 | inferred from mutant phenotype regulation of synaptic growth at neuromuscular junction ; GO:0008582 | inferred from mutant phenotype adult walking behavior ; GO:0007628 | non-traceable author statement protein ubiquitination ; GO:0016567 | inferred from sequence or structural similarity with UniProtKB:Q8WY64 synapse organization ; GO:0050808 | inferred from direct assay regulation of terminal button organization ; GO:2000331 | inferred from mutant phenotype long-term memory ; GO:0007616 | inferred from mutant phenotype detection of temperature stimulus involved in sensory perception of pain ; GO:0050965 | inferred from mutant phenotype locomotion ; GO:0040011 | non-traceable author statement BMP signaling pathway ; GO:0030509 | inferred from physical interaction with UniProtKB:O62609 negative regulation of synaptic growth at neuromuscular junction ; GO:0045886 | inferred from mutant phenotype autophagy ; GO:0006914 | inferred from direct assay plasma membrane ; GO:0005886 | inferred from direct assay cytoplasmic vesicle ; GO:0031410 | inferred from direct assay "CG9049, CG9041, CG32592, hiw, Hiw" "IPR000408:Regulator of chromosome condensation, RCC1, IPR001841:Zinc finger, RING-type, IPR012983:PHR, IPR008979:Galactose-binding domain-like, IPR009091:Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II, IPR014756:Immunoglobulin E-set, IPR004939:APC10/DOC domain, IPR017868:Filamin/ABP280 repeat-like, IPR013083:Zinc finger, RING/FYVE/PHD-type, IPR013783:Immunoglobulin-like fold" CG32592 27-Aug-18 DroID_v2018_08 Drer\mycbp2 - "Cele\F07B7.12, Cele\rpm-1" Xtro\mycbp2 Mmus\Mycbp2 Hsap\MYCBP2 "neuroanatomy defective,conditional,neurophysiology defective,somatic clone,decreased cell growth,recessive,locomotor behavior defective,viable" "embryonic/larval neuromuscular junction,NMJ bouton,supernumerary,synapse,neuromuscular junction | larval stage,dorsal multidendritic neuron ddaC,neuromuscular junction,indirect flight muscle motor neuron MN4,terminal bouton,segmental nerve,conditional,bouton,wing vein L1,somatic clone,terminal boutonelav.Switch.PO,neuromuscular junctionelav.Switch.PO,synapseelav.Switch.PO,indirect flight muscle motor neuron MN4 & bouton | ectopic,neuroblast,synaptic vesicle,motor neuron,giant fiber neuron,tergotrochanteral muscle motor neuron,synapseelav.Switch.PO, hiwëÓRCC1.UAS.TZzzzTAP,synapseelav.Switch.PO, hiwëÓPHR.UAS.TZzzzTAP,synapseelav.Switch.PO, hiwHindIII.UAS.TZzzzHis6,THsapMYC,synapseelav.Switch.PO, hiwëÓN.UAS.TZzzzTAP,synapseelav.Switch.PO, hiwND8,eye" FBgn0003371 sgg shaggy http://flybase.org/reports/FBgn0003371 "FBgn0026697, FBgn0026849, FBgn0027246, FBgn0028324, FBgn0029071, FBgn0066814" protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 protein kinase activity ; GO:0004672 | inferred from direct assay protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:O16844 protein binding ; GO:0005515 | inferred from physical interaction with Axn protein serine/threonine kinase activity ; GO:0004674 | non-traceable author statement protein serine/threonine kinase activity ; GO:0004674 | inferred from sequence or structural similarity kinase activity ; GO:0016301 | inferred from direct assay" chitin-based larval cuticle pattern formation ; GO:0035293 | inferred from mutant phenotype circadian rhythm ; GO:0007623 | inferred from mutant phenotype oogenesis ; GO:0048477 | inferred from mutant phenotype negative regulation of smoothened signaling pathway ; GO:0045879 | inferred from mutant phenotype circadian rhythm ; GO:0007623 | traceable author statement wing and notum subfield formation ; GO:0035309 | inferred from mutant phenotype entrainment of circadian clock ; GO:0009649 | inferred from mutant phenotype positive regulation of protein catabolic process ; GO:0045732 | inferred from mutant phenotype establishment of epithelial cell planar polarity ; GO:0090163 | inferred from mutant phenotype inferred from genetic interaction with aPKC pseudocleavage involved in syncytial blastoderm formation ; GO:0030589 | non-traceable author statement response to anesthetic ; GO:0072347 | inferred from mutant phenotype negative regulation of JUN kinase activity ; GO:0043508 | inferred from mutant phenotype Notch signaling pathway ; GO:0007219 | traceable author statement rhythmic behavior ; GO:0007622 | traceable author statement regulation of proteolysis ; GO:0030162 | inferred from direct assay protein phosphorylation ; GO:0006468 | non-traceable author statement heart development ; GO:0007507 | non-traceable author statement Wnt signaling pathway ; GO:0016055 | traceable author statement protein phosphorylation ; GO:0006468 | inferred from direct assay circadian rhythm ; GO:0007623 | non-traceable author statement olfactory learning ; GO:0008355 | inferred from mutant phenotype female meiotic division ; GO:0007143 | inferred from mutant phenotype negative regulation of Wnt signaling pathway ; GO:0030178 | traceable author statement ovarian follicle cell development ; GO:0030707 | inferred from mutant phenotype somatic stem cell population maintenance ; GO:0035019 | inferred from mutant phenotype habituation ; GO:0046959 | inferred from mutant phenotype regulation of calcineurin-NFAT signaling cascade ; GO:0070884 | inferred from mutant phenotype epithelial cell morphogenesis ; GO:0003382 | inferred from mutant phenotype inferred from genetic interaction with aPKC regulation of microtubule cytoskeleton organization ; GO:0070507 | inferred from mutant phenotype positive regulation of proteasomal ubiquitin-dependent protein catabolic process ; GO:0032436 | inferred from direct assay negative regulation of synaptic growth at neuromuscular junction ; GO:0045886 | inferred from mutant phenotype heart development ; GO:0007507 | traceable author statement regulation of hemocyte differentiation ; GO:0045610 | inferred from mutant phenotype chaeta morphogenesis ; GO:0008407 | non-traceable author statement regulation of protein import into nucleus ; GO:0042306 | traceable author statement negative regulation of smoothened signaling pathway ; GO:0045879 | inferred from direct assay positive regulation of mitotic metaphase/anaphase transition ; GO:0045842 | inferred from mutant phenotype regulation of circadian rhythm ; GO:0042752 | inferred from mutant phenotype spindle organization ; GO:0007051 | inferred from mutant phenotype sensory organ development ; GO:0007423 | inferred from mutant phenotype segment polarity determination ; GO:0007367 | inferred from mutant phenotype locomotor rhythm ; GO:0045475 | non-traceable author statement synaptic growth at neuromuscular junction ; GO:0051124 | inferred from mutant phenotype nucleoplasm ; GO:0005654 | inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay cytosol ; GO:0005829 | inferred from direct assay centrosome ; GO:0005813 | inferred from direct assay axon ; GO:0030424 | inferred from direct assay mitotic spindle ; GO:0072686 | inferred from direct assay neuromuscular junction ; GO:0031594 | inferred from direct assay female germline ring canal ; GO:0035324 | inferred from direct assay fusome ; GO:0045169 | inferred from direct assay "GSK3, sgg, GSK3beta/SGG, Zw3, GSK, zw3, GSK3beta, Gsk3, GSK-3, GSKbeta, GSK-3beta, ZW3, CG2621, EG:155E2.3, Zw3-sh, DMSGG3, Sgg, SGG/GSK3b, Zw3/GSK3, sgg46, sgg39, sgg10, DMZ3K25Z, sgg-zw3, l(1)3Ba, zw-3, Zw-3, zw3[sgg], Zw3[sgg], zw3/sgg, sgg/zw3, zw[3], zw3(sgg), l(1)zw3, ZW-3, l(1)G0055, l(1)G0183, l(1)G0263, l(1)G0335, EG:BACR7C10.8, anon-WO03040301.254, gsk3, Dmsgg3, SGG, Sgg/Zw3/GSK3, Gsk-3, GSK-3B, GSK3betagr;, zw3/GSK3beta, Dm Zw3, GSK-3betaSgg, GSK3Beta, GSK3-beta, Gsk-3beta, GSK3A" "IPR000719:Protein kinase domain, IPR008271:Serine/threonine-protein kinase, active site, IPR011009:Protein kinase-like domain, IPR017441:Protein kinase, ATP binding site, IPR033573:Glycogen synthase kinase-3 beta" CG2621 27-Aug-18 DroID_v2018_08 "Drer\gsk3aa, Drer\si:dkeyp-80c12.7, Drer\gsk3b, Drer\gsk3ab" "Scer\YGK3, Scer\MCK1, Scer\RIM11, Scer\MRK1" "Cele\C44H4.6, Cele\ire-1, Cele\gck-1, Cele\R03D7.5, Cele\gsk-3" "Xtro\gsk3a, Xtro\gsk3b" "Mmus\Gsk3b, Mmus\Gsk3a" "Hsap\GSK3B, Hsap\GSK3A, Hsap\MYLK" larval stage | third instar nerve terminal | subset

"lethal,recessive,visible,somatic clone,viable,locomotor rhythm defective,circadian rhythm defective,behavior defective,neuroanatomy defective,neurophysiology defective,lethal - all die before end of P-stage,some die during pharate adult stage,lethal - all die before end of pupal stage,some die during pupal stage,wild-type,maternal effect,germline clone,developmental rate defective,mitotic cell cycle defective,planar polarity defective,cell non-autonomous,cell polarity defective,lethal - all die before end of embryonic stage,some die during embryonic stage,rescuable maternal effect,lethal - all die before end of larval stage,some die during larval stage,non-rescuable maternal effect,some die during third instar larval stage,meiotic cell cycle defective,short lived,smell perception defective,heat sensitive,fertile,chemical sensitive" "eye,somatic clone,eye disc,macrochaeta,supernumerary,synapse,macrochaeta & wing,embryonic/larval dorsal vessel,ommatidium,embryonic/first instar larval cuticle,germline clone,maternal effect,denticle belt,embryonic head,embryonic/larval spiracle,filzkorper,presumptive embryonic/larval peripheral nervous system,presumptive embryonic/larval central nervous system,embryonic/larval brain,wing,leg,tibia,tarsal segment,ventral thoracic disc,ventral thoracic disc & macrochaeta | somatic clone,syncytial blastoderm embryo,nucleus | embryonic stage 4 | germline clone,follicle stem cell,germline cyst,follicle cell,embryonic epidermis,dorsal,dorsal hair,embryonic Malpighian tubule,mesothoracic tarsal bristle longitudinal row 2,mesothoracic tarsal bristle longitudinal row 3,mesothoracic tarsal bristle longitudinal row 4,mesothoracic tarsal bristle longitudinal row 5,mesothoracic tarsal bristle longitudinal row 6,mesothoracic tarsal bristle longitudinal row 7,abdominal 1 ventral denticle belt,abdominal 2 ventral denticle belt,abdominal 3 ventral denticle belt,abdominal 4 ventral denticle belt,abdominal 5 ventral denticle belt,abdominal 6 ventral denticle belt,abdominal 7 ventral denticle belt,denticle,rescuable maternal effect,embryonic/larval somatic muscle,stomodeal invagination,midgut constriction 1,ectopic,posterior compartment,precursor,cell non-autonomous,wing margin bristle,wing vein,sensillum campaniformium,wing blade,mechanosensory ventral triple row bristle,wing sensillum,imaginal disc,egg,female reproductive system,wing hair,non-rescuable maternal effect,embryonic/larval neuromuscular junction,bouton,external sensory organ precursor cell,microchaeta,adult cuticle & abdomen | somatic clone,anterior,adult thorax & macrochaeta | somatic clone,adult thorax & microchaeta | somatic clone,cuticle,macrochaeta & wing | ectopic | somatic clone,1st axillary sclerite,2nd axillary sclerite,3rd axillary sclerite,unnamed wing hinge sclerite,axillary pouch,macrochaeta & mesothoracic tergum | somatic clone | cell autonomous,macrochaeta & scutum | somatic clone | cell autonomous,cell autonomous,macrochaeta & prescutum | somatic clone | cell autonomous,sensory mother cell,NMJ bouton,dendritic arborizing neuron | third instar larval stage,wing margin,mesothoracic tergum,morphogenetic furrow,melanotic mass,lamellocyte,crystal cell,scutellum,adult thorax & chaeta-537.4,dorsocentral bristle,posterior dorsocentral bristle,bouton | larval stage,scutellar bristle,wing disc,adult thorax & microchaeta-537.4,synapse796,antennal lobe,synapseGH298,intrinsic neuron,antennal lobe glomerulus DM2,synapseNP1227,synapsekra-krasavietz,synapseSxl-NP2426,synapseSxl-NP2426, kra-krasavietz,synapseTab2-201Y,adult mushroom body,eye | pharate adult stage,head | pharate adult stage,synapseD42,adult thorax,dorsal denticle,cuprophilic cell,midgut constriction 2,interommatidial bristle" FBgn0004101 bs blistered http://flybase.org/reports/FBgn0004101 "FBgn0000156, FBgn0000223, FBgn0010354, FBgn0010535" protein_coding_gene "protein dimerization activity ; GO:0046983 | inferred from electronic annotation with InterPro:IPR002100 core promoter proximal region sequence-specific DNA binding ; GO:0000987 | inferred from electronic annotation with InterPro:IPR033897 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ; GO:0001077 | contributes_to inferred from physical interaction with Mrtf activating transcription factor binding ; GO:0033613 | inferred from physical interaction with Mrtf" "terminal branching, open tracheal system ; GO:0007430 | traceable author statement terminal cell fate specification, open tracheal system ; GO:0035154 | traceable author statement short-term memory ; GO:0007614 | inferred from mutant phenotype cell fate commitment ; GO:0045165 | traceable author statement pupal development ; GO:0035209 | inferred from mutant phenotype imaginal disc-derived wing vein morphogenesis ; GO:0008586 | inferred from mutant phenotype instar larval development ; GO:0002168 | inferred from mutant phenotype imaginal disc-derived wing morphogenesis ; GO:0007476 | traceable author statement cell differentiation ; GO:0030154 | inferred from mutant phenotype apposition of dorsal and ventral imaginal disc-derived wing surfaces ; GO:0007475 | inferred from mutant phenotype open tracheal system development ; GO:0007424 | inferred from expression pattern imaginal disc-derived wing morphogenesis ; GO:0007476 | inferred from mutant phenotype terminal branching, open tracheal system ; GO:0007430 | non-traceable author statement wing disc development ; GO:0035220 | inferred from mutant phenotype terminal branching, open tracheal system ; GO:0007430 | inferred from mutant phenotype sleep ; GO:0030431 | inferred from mutant phenotype imaginal disc-derived wing morphogenesis ; GO:0007476 | non-traceable author statement open tracheal system development ; GO:0007424 | traceable author statement positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 | inferred from direct assay" nucleus ; GO:0005634 | inferred from direct assay "bs/DSRF, DSRF, SRF, D-SRF, dSRF, BS, DmSRF, Group IIc, DSrf/bs, pruned/DSRF, dsrf, Srf, DSrf, px, ba, l(2)03267, Serf, CG3411, bs, bs/Dsrf, Bs, Mal, srf" "IPR002100:Transcription factor, MADS-box, IPR033897:MADS SRF-like" CG3411 27-Aug-18 DroID_v2018_08 "Drer\srfb, Drer\srfa" "Scer\MCM1, Scer\ARG80" "Cele\mef-2, Cele\unc-120" Xtro\srf Mmus\Srf Hsap\SRF " embryonic stage | >=stage 14 , embryonic stage | stage 16 , embryonic stage | stage >=14 " " abdominal segment 1--8

, embryonic/larval somatic muscle

, metathoracic segment | restricted

, embryonic central nervous system | restricted

, mesothoracic segment | restricted

, embryonic/larval midgut

, embryonic/larval hindgut

, pharyngeal muscle

" " embryonic stage | stage >=14 , embryonic stage | stage 16 , embryonic stage | >=stage 14 , pupal stage " " metathoracic segment | restricted

, mesothoracic segment | restricted

, embryonic/larval midgut

, embryonic/larval somatic muscle

, pharyngeal muscle

, abdominal segment 1--8

, embryonic/larval hindgut

, wing

, embryonic central nervous system | restricted

" "visible,recessive,viable,poor,fertile,semidominant,dominant,lethal,memory defective,lethal - all die before end of larval stage,some die during larval stage,heat sensitive,lethal - all die before end of embryonic stage,some die during embryonic stage,lethal - all die before end of P-stage,some die during pharate adult stage,somatic clone,wild-type,decreased cell size,cell autonomous,lethal - all die before end of pupal stage,some die during pupal stage,courtship behavior defective,locomotor behavior defective" "wing,wing vein,ectopic,trachea,wing cell,embryonic/larval tracheal system,somatic clone,tracheal metamere 3,wing vein L3 & sensillum campaniformium,sensillum campaniformium,wing & macrochaeta,macrochaeta,wing sensillum,tarsal segment,femur,rhabdomere,submarginal cell,wing disc,embryonic/first instar larval cuticle,cephalopharyngeal skeleton,presumptive embryonic/larval tracheal system,cell non-autonomous,border follicle cell,follicle cell & actin filament | somatic clone,chaeta" FBgn0263977 Tim17b Translocase of the inner mitochondrial membrane 17b http://flybase.org/reports/FBgn0263977 protein_coding_gene protein channel activity ; GO:0015266 | contributes_to inferred from biological aspect of ancestor with PANTHER:PTN000050380 protein import into mitochondrial matrix ; GO:0030150 | inferred from biological aspect of ancestor with PANTHER:PTN000050380 protein targeting to mitochondrion ; GO:0006626 | inferred from mutant phenotype mitochondrion ; GO:0005739 | inferred from direct assay integral component of mitochondrial inner membrane ; GO:0031305 | inferred from biological aspect of ancestor with PANTHER:PTN000050380 mitochondrial inner membrane presequence translocase complex ; GO:0005744 | inferred from biological aspect of ancestor with PANTHER:PTN000050380 "Tim17b, CG40451" IPR003397:Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24 CG40451 27-Aug-18 DroID_v2018_08 "Drer\timm17a, Drer\timm17b" Scer\TIM17 "Cele\D2096.1, Cele\E04A4.5" Xtro\timm17a "Mmus\Timm17b, Mmus\Timm17a" "Hsap\TIMM17B, Hsap\TIMM17A" "increased cell death,lethal - all die before end of embryonic stage,some die during embryonic stage" mitochondrionunspecified FBgn0000233 btd buttonhead http://flybase.org/reports/FBgn0000233 - protein_coding_gene "transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding ; GO:0003705 | inferred from direct assay sequence-specific DNA binding ; GO:0043565 | inferred from direct assay transcription factor binding ; GO:0008134 | inferred from physical interaction with Taf4 inferred from physical interaction with Taf2 transcription factor activity, sequence-specific DNA binding ; GO:0003700 | inferred from direct assay inferred from genetic interaction with HGNC:11205" posterior head segmentation ; GO:0035289 | traceable author statement positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 | inferred from direct assay negative regulation of transcription from RNA polymerase II promoter ; GO:0000122 | inferred from mutant phenotype cephalic furrow formation ; GO:0007376 | inferred from mutant phenotype imaginal disc-derived leg morphogenesis ; GO:0007480 | inferred from mutant phenotype anterior head segmentation ; GO:0035288 | traceable author statement nucleus ; GO:0005634 | inferred from biological aspect of ancestor with PANTHER:PTN001145452 "btd, BTD, CG12653, Btd, buttonhead" "IPR013087:Zinc finger C2H2-type, IPR013083:Zinc finger, RING/FYVE/PHD-type, IPR015943:WD40/YVTN repeat-like-containing domain" CG12653 27-Aug-18 DroID_v2018_08 "Drer\zgc:153115, Drer\sp3b, Drer\zgc:77358, Drer\sp9, Drer\sp3a, Drer\klf13, Drer\sp5l, Drer\sp2, Drer\sp4, Drer\sp1, Drer\klf11b, Drer\sp5b, Drer\sp7, Drer\sp8a, Drer\sp8b, Drer\sp5a" "Scer\FZF1, Scer\ACE2, Scer\MOT3, Scer\SWI5, Scer\CRZ1" "Cele\sptf-1, Cele\sptf-3, Cele\sptf-2" "Xtro\sp4, Xtro\sp5l, Xtro\sp2, Xtro\sp7, Xtro\sp5, Xtro\sp1, Xtro\sp6, Xtro\sp3" "Mmus\Sp6, Mmus\Sp9, Mmus\Sp5, Mmus\Sp4, Mmus\Sp7, Mmus\Egr1, Mmus\Egr4, Mmus\Klf13, Mmus\Sp1, Mmus\Sp8, Mmus\Egr3, Mmus\Zfp526, Mmus\Egr2, Mmus\Sp2" "Hsap\EGR1, Hsap\ZNF526, Hsap\SP7, Hsap\SP8, Hsap\EGR3, Hsap\SP9, Hsap\SP6, Hsap\SP4, Hsap\SP1, Hsap\SP5, Hsap\SP2, Hsap\SP3, Hsap\KLF13" " embryonic stage | embryonic cycle 12-14 , embryonic stage | blastoderm , embryonic stage | late , embryonic stage , embryonic stage | mid , embryonic stage | stage 3,4 , embryonic stage | stage 6,7 , embryonic stage | stage 5 , embryonic stage | stage 7-17 " " organism | 60-80% egg length

, embryonic intercalary segment | precursor

, ventral nerve cord | restricted

, embryonic deuterocerebrum | precursor

, embryonic mandibular segment | precursor

, organism | striped

, embryonic peripheral nervous system | restricted

, embryonic head | restricted

, cephalic furrow | anterior to

, leg | precursor

, organism | 70-80% egg length

, neuroblast

, procephalic neurogenic region | restricted

" "wild-type,lethal - all die before end of embryonic stage,recessive,some die during embryonic stage,visible,homeotic,somatic clone,viable" "papilla organ,antennal segment,mandibular segment,antenna,cephalopharyngeal skeleton,ventral,embryo,embryonic abdominal segment,embryonic head & sclerite | ectopic,embryonic head,embryonic mandibular segment,embryonic intercalary segment,embryonic antennal segment,abdominal 1 lateral pentascolopidial chordotonal organ lch5,abdominal 2 lateral pentascolopidial chordotonal organ lch5,abdominal 3 lateral pentascolopidial chordotonal organ lch5,abdominal 4 lateral pentascolopidial chordotonal organ lch5,abdominal 5 lateral pentascolopidial chordotonal organ lch5,abdominal 6 lateral pentascolopidial chordotonal organ lch5,abdominal 7 lateral pentascolopidial chordotonal organ lch5,cephalic furrow,associated organ,dorsolateral papilla,embryonic/larval optic lobe,antennal sense organ,lateropharyngeal organ,maxillary segment,anterior,scolopidium,deuterocerebral neuromere,tritocerebral neuromere,intercalary segment,anterior pharyngeal organ,Keilin's organ,embryonic Malpighian tubule,femur,somatic clone - Minute background,tibia,eye,ectopic,wing,haltere,leg,somatic clone,wing margin bristle,distal,proximal" FBgn0005626 ple pale http://flybase.org/reports/FBgn0005626 "FBgn0003109, FBgn0003692" protein_coding_gene "tyrosine 3-monooxygenase activity ; GO:0004511 | inferred from electronic annotation with InterPro:IPR005962 iron ion binding ; GO:0005506 | inferred from electronic annotation with InterPro:IPR001273, InterPro:IPR018301 tyrosine 3-monooxygenase activity ; GO:0004511 | non-traceable author statement tyrosine 3-monooxygenase activity ; GO:0004511 | traceable author statement" "oxidation-reduction process ; GO:0055114 | inferred from electronic annotation with InterPro:IPR001273, InterPro:IPR005962, InterPro:IPR018301, InterPro:IPR019773, InterPro:IPR019774 aromatic amino acid family metabolic process ; GO:0009072 | inferred from electronic annotation with InterPro:IPR001273, InterPro:IPR018301 dopamine biosynthetic process ; GO:0042416 | inferred from mutant phenotype male courtship behavior ; GO:0008049 | inferred from mutant phenotype catecholamine metabolic process ; GO:0006584 | non-traceable author statement developmental pigmentation ; GO:0048066 | traceable author statement cuticle pigmentation ; GO:0048067 | inferred from mutant phenotype wing disc development ; GO:0035220 | inferred from mutant phenotype dopamine metabolic process ; GO:0042417 | inferred from mutant phenotype courtship behavior ; GO:0007619 | non-traceable author statement regulation of adult chitin-containing cuticle pigmentation ; GO:0048082 | inferred from mutant phenotype inferred from genetic interaction with Ask1 thermotaxis ; GO:0043052 | inferred from mutant phenotype regulation of epithelial cell migration, open tracheal system ; GO:2000274 | inferred from mutant phenotype thermosensory behavior ; GO:0040040 | inferred from mutant phenotype adult locomotory behavior ; GO:0008344 | inferred from mutant phenotype response to wounding ; GO:0009611 | inferred from expression pattern adult chitin-containing cuticle pigmentation ; GO:0048085 | inferred from mutant phenotype" - "TH, DTH, Pale, CG10118, Th, VII, DH65B, pale, dTH65B, ple, pale/ple, th, dTH1, Ple" "IPR018301:Aromatic amino acid hydroxylase, iron/copper binding site, IPR001273:Aromatic amino acid hydroxylase, IPR005962:Tyrosine 3-monooxygenase, IPR019774:Aromatic amino acid hydroxylase, C-terminal, IPR019773:Tyrosine 3-monooxygenase-like" CG10118 27-Aug-18 DroID_v2018_08 "Drer\tph2, Drer\th2, Drer\tph1b, Drer\tph1a, Drer\pah, Drer\th" - "Cele\cat-2, Cele\tph-1, Cele\pah-1" "Xtro\tph1, Xtro\pah, Xtro\th" "Mmus\Th, Mmus\Tph1, Mmus\Tph2, Mmus\Pah" "Hsap\TH, Hsap\PAH, Hsap\TPH1, Hsap\TPH2" " adult stage , larval stage && adult stage , larval stage | third instar , larval stage , larval stage | first instar " " adult abdomen

, adult brain

, central nervous system

, adult head

, adult thorax

, epidermis

, larval central nervous system

" "visual behavior defective,phototaxis defective,locomotor rhythm defective,sleep defective,hypoactive,smell perception defective,gravitaxis defective,wild-type,lethal,recessive,heat sensitive,lethal - all die before end of embryonic stage,some die during embryonic stage,visible,somatic clone,body color defective,thermotaxis behavior defective,dominant,locomotor behavior defective,courtship behavior defective,feeding behavior defective,long lived,drug conditional,memory defective,viable" "wing,embryonic/larval tracheal system,embryonic/larval dorsal trunk,embryonic/first instar larval cuticle,cephalopharyngeal skeleton,adult cuticle,somatic clone,microchaeta,mouth hooks,cuticle,spiracle,macrochaeta,serotonergic neuron,wing cell,adult abdomen,adult thorax,dopaminergic neuron,drug conditional,mesothoracic tergum" DRSC11383 IEK 0.763470174 -1.621909565 -1.525471935 -2.188261945 -2.821184033 -3.427405512 FBgn0052671 Rab9Fa Rab at 9Fa http://flybase.org/reports/FBgn0052671 protein_coding_gene "GTP binding ; GO:0005525 | inferred from electronic annotation with InterPro:IPR001806, InterPro:IPR003579, InterPro:IPR005225 GTPase activity ; GO:0003924 | inferred from sequence or structural similarity with Rab11" endocytic recycling ; GO:0032456 | inferred from biological aspect of ancestor with PANTHER:PTN001178320 vesicle-mediated transport ; GO:0016192 | inferred from sequence or structural similarity with Rab11 Rab protein signal transduction ; GO:0032482 | inferred from sequence or structural similarity with Rab11 endosome membrane ; GO:0010008 | inferred from biological aspect of ancestor with PANTHER:PTN001178320 plasma membrane ; GO:0005886 | inferred from biological aspect of ancestor with PANTHER:PTN001178320 vesicle ; GO:0031982 | inferred from sequence or structural similarity with Rab11 "DmRabX3, CG2532, Rab9Fa, CG32671, RabX3" "IPR001806:Small GTPase superfamily, IPR005225:Small GTP-binding protein domain, IPR027417:P-loop containing nucleoside triphosphate hydrolase" CG32671 27-Aug-18 DroID_v2018_08 "Drer\rab35a, Drer\si:dkey-16l2.16, Drer\rab19, Drer\zgc:171927, Drer\zgc:101559, Drer\rsg1, Drer\rabl6a, Drer\rab1aa, Drer\rab33ba, Drer\rab1ba, Drer\rab43, Drer\rab33a, Drer\rab1ab, Drer\rab35b, Drer\rab1bb, Drer\rabl6b" "Scer\TEM1, Scer\YPT1" "Cele\rab-28, Cele\rab-35" "Xtro\rabl6, Xtro\rab33a, Xtro\rab28, Xtro\rab19, Xtro\rab33b, Xtro\rab1a" "Mmus\Rab33b, Mmus\Rabl6, Mmus\Rab35, Mmus\Rab1b, Mmus\Rab43, Mmus\Rab1a, Mmus\Rsg1, Mmus\Rab28, Mmus\Rab19, Mmus\Rab33a" "Hsap\RAB33A, Hsap\RAB33B, Hsap\RAB28, Hsap\RAB19, Hsap\RAB1A, Hsap\RABL6, Hsap\RSG1, Hsap\RAB1B, Hsap\RAB43, Hsap\RAB35" FBgn0024545 l(3)L3130 lethal (3) L3130 http://flybase.org/reports/FBgn0024545 - gene - - - l(3)L3130 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0061129 l(3)S003003a lethal (3) S003003a http://flybase.org/reports/FBgn0061129 gene - - - "l(3)S003003, 0030/03, l(3)S003003a" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0005371 whg whiting http://flybase.org/reports/FBgn0005371 - gene - - - whg - - 27-Aug-18 DroID_v2018_08 - - - - - - eye color defective eye FBgn0060763 l(3)S063207 lethal (3) S063207 http://flybase.org/reports/FBgn0060763 gene - - - "0632/07, l(3)S063207" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0264862 asRNA:CR44053 - http://flybase.org/reports/FBgn0264862 non_protein_coding_gene - - - CR44053 - CR44053 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0259933 CG42456 - http://flybase.org/reports/FBgn0259933 protein_coding_gene enzyme regulator activity ; GO:0030234 | inferred from electronic annotation with InterPro:IPR009914 dolichol metabolic process ; GO:0019348 | inferred from electronic annotation with InterPro:IPR009914 integral component of endoplasmic reticulum membrane ; GO:0030176 | inferred from electronic annotation with InterPro:IPR009914 "CG42456, Dromel_CG12016_FBtr0073063_uORF" IPR009914:Dolichol phosphate-mannose biosynthesis regulatory CG42456 27-Aug-18 DroID_v2018_08 Drer\dpm2 Scer\YIL102C-A - - Mmus\Dpm2 Hsap\DPM2 FBgn0039282 Bili Band4.1 inhibitor LRP interactor http://flybase.org/reports/FBgn0039282 protein_coding_gene molecular_function ; GO:0003674 | no biological data available regulation of establishment of protein localization ; GO:0070201 | inferred from mutant phenotype negative regulation of Wnt signaling pathway ; GO:0030178 | inferred from mutant phenotype cytoskeleton ; GO:0005856 | inferred from electronic annotation with InterPro:IPR000299 plasma membrane ; GO:0005886 | colocalizes_with inferred from direct assay "Bili, CG11848, dBili" "IPR000299:FERM domain, IPR014352:FERM/acyl-CoA-binding protein, 3-helical bundle, IPR019748:FERM central domain, IPR019749:Band 4.1 domain, IPR011993:PH domain-like" CG11848 27-Aug-18 DroID_v2018_08 "Drer\krit1, Drer\frmd8" - "Cele\kri-1, Cele\frm-10" Xtro\frmd8 "Mmus\Krit1, Mmus\Frmd8" "Hsap\KRIT1, Hsap\FRMD8" "viable,fertile" embryonic/first instar larval cuticle DRSC14405 IE 2.30752901 1.149307697 4.38860131 -0.530758612 1.121567693 0.456002575 FBgn0264001 bru3 bruno 3 http://flybase.org/reports/FBgn0264001 protein_coding_gene RNA binding ; GO:0003723 | inferred from direct assay mRNA binding ; GO:0003729 | inferred from sequence or structural similarity protein homodimerization activity ; GO:0042803 | inferred from direct assay negative regulation of translation ; GO:0017148 | inferred from sequence alignment with bru1 protein complex ; GO:0043234 | inferred from direct assay "CG43744, bruno-3, CG10046, CG12478, Dm Bru-3, cg12478, cg10046, Bru-3, l(3)05871, CG34243, bru-3, bru3" IPR000504:RNA recognition motif domain CG43744 27-Aug-18 DroID_v2018_08 "Drer\si:dkey-205h23.2, Drer\celf3b, Drer\zgc:165603, Drer\celf5b, Drer\hug, Drer\celf2, Drer\celf1, Drer\celf5a, Drer\celf3a, Drer\celf4" - "Cele\unc-75, Cele\etr-1" "Xtro\celf1, Xtro\celf3, Xtro\celf4, Xtro\celf5, Xtro\celf2" "Mmus\Celf6, Mmus\Celf4, Mmus\Celf3, Mmus\Celf2, Mmus\Celf5, Mmus\Celf1" "Hsap\CELF3, Hsap\CELF6, Hsap\CELF2, Hsap\CELF4, Hsap\CELF1, Hsap\CELF5" DRSC22732 K -0.392388607 0.492353085 0.415812704 0.672242204 1.642179667 1.863616238 FBgn0259390 C403 - http://flybase.org/reports/FBgn0259390 gene - - - C403 - - 27-Aug-18 DroID_v2018_08 - - - - - - visible "wing,wing margin,chaeta,ectopic" FBgn0050340 CG30340 - http://flybase.org/reports/FBgn0050340 protein_coding_gene G-protein coupled receptor activity ; GO:0004930 | inferred from electronic annotation with InterPro:IPR000276 neuropeptide receptor activity ; GO:0008188 | inferred from sequence model G-protein coupled receptor signaling pathway ; GO:0007186 | inferred from electronic annotation with InterPro:IPR000276 G-protein coupled receptor signaling pathway ; GO:0007186 | inferred from sequence model "integral component of membrane ; GO:0016021 | inferred from electronic annotation with InterPro:IPR000276, InterPro:IPR017452 integral component of membrane ; GO:0016021 | inferred from sequence model" "BG:BACR48G21.1, BACR48G21.1, CG30340" "IPR000276:G protein-coupled receptor, rhodopsin-like, IPR017452:GPCR, rhodopsin-like, 7TM" CG30340 27-Aug-18 DroID_v2018_08 "Drer\mtnr1bb, Drer\mtnr1al, Drer\mtnr1c, Drer\mtnr1ab, Drer\mtnr1aa, Drer\mtnr1ba" - "Cele\npr-35, Cele\npr-5, Cele\npr-12, Cele\npr-8, Cele\npr-11" "Xtro\mtnr1c, Xtro\mtnr1b, Xtro\LOC100486065" "Mmus\Gpr50, Mmus\Mtnr1b, Mmus\Gpr3, Mmus\Mtnr1a" "Hsap\GPR3, Hsap\MTNR1B, Hsap\MTNR1A, Hsap\GPR50" "viable,visible" "trichogen cell,mesothoracic tergum" FBgn0038386 CG5478 - http://flybase.org/reports/FBgn0038386 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG5478 - CG5478 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0069990 BG01954 BG01954 http://flybase.org/reports/FBgn0069990 gene - - - BG01954 - - 27-Aug-18 DroID_v2018_08 - - - - - - stress response defective FBgn0043979 Su(tor)293-12-3 Su(tor)293-12-3 http://flybase.org/reports/FBgn0043979 gene - - - "293-12-3, Su(tor)293-12-3" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0053201 CG33201 - http://flybase.org/reports/FBgn0053201 protein_coding_gene - - - CG33201 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0060308 l(3)S148214 lethal (3) S148214 http://flybase.org/reports/FBgn0060308 gene - - - "1482/14, l(3)S148214" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0259258 EP-165 - http://flybase.org/reports/FBgn0259258 gene - - - EP-165 - - 27-Aug-18 DroID_v2018_08 - - - - - - visible "wing vein,wing" FBgn0020652 HIF Hypoxia Inducible Factor http://flybase.org/reports/FBgn0020652 - gene molecular_function ; GO:0003674 | no biological data available - cellular_component ; GO:0005575 | no biological data available "HIF-1, HIF-D, Hif-1, HIF" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0051634 Oatp26F Organic anion transporting polypeptide 26F http://flybase.org/reports/FBgn0051634 protein_coding_gene transmembrane transporter activity ; GO:0022857 | inferred from sequence or structural similarity with Oatp58Db active transmembrane transporter activity ; GO:0022804 | inferred from sequence or structural similarity with Oatp58Db organic substance transport ; GO:0071702 | inferred from sequence or structural similarity with Oatp58Db integral component of plasma membrane ; GO:0005887 | inferred from sequence or structural similarity with Oatp58Db "CG31634, oatp 26F, CG18784, CG13767, CG11332, Oatp26F, oatp26F" "IPR004156:Organic anion transporter polypeptide OATP, IPR002350:Kazal domain, IPR020846:Major facilitator superfamily domain" CG31634 27-Aug-18 DroID_v2018_08 "Drer\slco1f2, Drer\LOC570448, Drer\slco1f3, Drer\slco1f4, Drer\slco4a1, Drer\LOC100536648, Drer\slco2b1, Drer\slco5a1, Drer\slco3a1, Drer\LOC101883455, Drer\slco1c1" - "Cele\K02G10.5, Cele\Y70G10A.3, Cele\F53B1.8" "Xtro\slco3a1, Xtro\slco5a1, Xtro\slco2a1, Xtro\slco1b3, Xtro\slco4a1, Xtro\slco4c1" "Mmus\Slco1b2, Mmus\Slco6d1, Mmus\Slco1a1, Mmus\Slco2b1, Mmus\Slco1a4, Mmus\Slco1c1, Mmus\Slco1a5, Mmus\Slco4c1, Mmus\Gm6614, Mmus\Slco4a1, Mmus\Slco1a6, Mmus\Gm5724, Mmus\Slco5a1, Mmus\Slco2a1, Mmus\Slco6c1, Mmus\Slco3a1" "Hsap\SLCO4A1, Hsap\SLCO1B7, Hsap\SLCO4C1, Hsap\SLCO6A1, Hsap\SLCO2A1, Hsap\SLCO1B3, Hsap\SLCO1A2, Hsap\SLCO5A1, Hsap\SLCO1B1, Hsap\SLCO1C1, Hsap\SLCO3A1, Hsap\SLCO2B1" viable FBgn0027254 l(1)G0249 lethal (1) G0249 http://flybase.org/reports/FBgn0027254 - gene - - - l(1)G0249 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0265512 mlt mulet http://flybase.org/reports/FBgn0265512 protein_coding_gene molecular_function ; GO:0003674 | no biological data available spermatid development ; GO:0007286 | inferred from mutant phenotype sperm individualization ; GO:0007291 | inferred from mutant phenotype positive regulation of microtubule depolymerization ; GO:0031117 | inferred from mutant phenotype axoneme ; GO:0005930 | inferred from direct assay "CG12214, mlt, ms(2)4210, ms(2)ry3, ms(2)ry-3, ms(2)3, Tbcel, TBCE-like, TBCEL" "IPR032675:Leucine-rich repeat domain, L domain-like, IPR029071:Ubiquitin-related domain, IPR000626:Ubiquitin domain" CG12214 27-Aug-18 DroID_v2018_08 "Drer\tbcelb, Drer\tbcela, Drer\tbce" Scer\PAC2 "Cele\coel-1, Cele\tbce-1" Xtro\tbcel "Mmus\Tbce, Mmus\Tbcel" "Hsap\TBCE, Hsap\TBCEL" DRSC27515 K 0.371158683 0.177647002 -0.25916353 -0.37351947 -0.13896648 1.745850798 FBgn0046329 l(2)38Ca lethal (2) 38Ca http://flybase.org/reports/FBgn0046329 gene - - - l(2)38Ca - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0027581 CG6191 - http://flybase.org/reports/FBgn0027581 - protein_coding_gene - regulation of cell cycle ; GO:0051726 | inferred from electronic annotation with InterPro:IPR012388 phagocytosis ; GO:0006909 | inferred from mutant phenotype regulation of imaginal disc-derived wing size ; GO:0044719 | inferred from mutant phenotype - "BcDNA:GH06193, CG6191, Dromel_CG6191_FBtr0087678_mORF" "IPR012388:CDK5 and ABL1 enzyme substrate 1/2, IPR015943:WD40/YVTN repeat-like-containing domain, IPR006671:Cyclin, N-terminal, IPR013763:Cyclin-like" CG6191 27-Aug-18 DroID_v2018_08 "Drer\cables2a, Drer\cables2b, Drer\cables1" - Cele\Y71F9B.6 "Xtro\cables1, Xtro\cables2" "Mmus\Cables2, Mmus\Cables1" "Hsap\CABLES1, Hsap\CABLES2" "viable,fertile,size defective" "wing,posterior" FBgn0035425 CG17746 - http://flybase.org/reports/FBgn0035425 protein_coding_gene cation binding ; GO:0043169 | inferred from electronic annotation with InterPro:IPR000222 protein serine/threonine phosphatase activity ; GO:0004722 | inferred from electronic annotation with InterPro:IPR015655 phosphoprotein phosphatase activity ; GO:0004721 | inferred from sequence or structural similarity with MGI:MGI:99878 protein serine/threonine phosphatase activity ; GO:0004722 | non-traceable author statement protein dephosphorylation ; GO:0006470 | non-traceable author statement protein dephosphorylation ; GO:0006470 | inferred from sequence or structural similarity with MGI:MGI:99878 cytosol ; GO:0005829 | inferred from sequence or structural similarity with MGI:MGI:99878 "CG17746, PP2C, Cg17746" "IPR000222:PPM-type phosphatase, divalent cation binding, IPR001932:PPM-type phosphatase domain, IPR015655:Protein phosphatase 2C family" CG17746 27-Aug-18 DroID_v2018_08 "Drer\ppm1bb, Drer\ppm1nb, Drer\ppm1g, Drer\ppm1aa, Drer\ppm1ab, Drer\ppm1ba, Drer\ppm1na, Drer\ppm1f" "Scer\PTC1, Scer\PTC2, Scer\PTC3, Scer\PTC4" "Cele\fem-2, Cele\ppm-1, Cele\F42G9.1, Cele\ppm-2" "Xtro\ppm1b, Xtro\ppm1a" "Mmus\Ppm1g, Mmus\Tab1, Mmus\Ppm1f, Mmus\Ppm1n, Mmus\Ppm1b, Mmus\Ppm1e, Mmus\Ppm1a" "Hsap\PPM1E, Hsap\PPM1A, Hsap\PPM1F, Hsap\TAB1, Hsap\PPM1G, Hsap\PPM1N, Hsap\PPM1B" "viable,fertile,lethal" DRSC08521 E 0.012788365 1.009485774 0.993251345 1.900285157 -0.374090839 -0.240521204 FBgn0060825 l(3)S051303 lethal (3) S051303 http://flybase.org/reports/FBgn0060825 gene - - - "0513/03, l(3)S051303" - - 27-Aug-18 DroID_v2018_08 - - - - - - "partially lethal - majority die,recessive" FBgn0065302 l(2)SH1985 lethal (2) SH1985 http://flybase.org/reports/FBgn0065302 gene - - - "l(2)SH1985, l(2)SH2 1985" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0002083 l(2)49Fl lethal (2) 49Fl http://flybase.org/reports/FBgn0002083 - gene - - - "vr-15, l(2)vr15, l(2)49Fl" - - 27-Aug-18 DroID_v2018_08 - - - - - - "partially lethal - majority die,recessive,heat sensitive,non-suppressor of variegation,dominant" FBgn0016744 Su(Raf)3C Su(Raf)3C http://flybase.org/reports/FBgn0016744 - gene - - - Su(Raf)3C - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0026647 l(2)8bb lethal (2) 8bb http://flybase.org/reports/FBgn0026647 - gene - - - "8bb, l(2)8bb" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0265737 lncRNA:CR44544 - http://flybase.org/reports/FBgn0265737 non_protein_coding_gene - - - "CR44544, incRNA.494, lincRNA.494" - CR44544 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0011770 Gip GIP-like http://flybase.org/reports/FBgn0011770 - protein_coding_gene hydroxypyruvate isomerase activity ; GO:0008903 | inferred from sequence or structural similarity with UniProtKB:P30147 glyoxylate metabolic process ; GO:0046487 | inferred from sequence or structural similarity with UniProtKB:P30147 extracellular region ; GO:0005576 | inferred from direct assay "CG2227, T15, Gip, gene C" "IPR013022:Xylose isomerase-like, TIM barrel domain, IPR026040:Hydroxypyruvate isomerase-like" CG2227 27-Aug-18 DroID_v2018_08 Drer\hyi - Cele\C05D11.5 Xtro\hyi Mmus\Hyi Hsap\HYI viable FBgn0011909 tRNA:Leu-CAA-2-1 transfer RNA:Leucine-CAA 2-1 http://flybase.org/reports/FBgn0011909 "FBgn0003789, FBgn0052840, FBgn0052841, FBgn0060163" tRNA_gene UUG codon-amino acid adaptor activity ; GO:0033404 | inferred from sequence model translation ; GO:0006412 | inferred by curator from GO:0033404 cytosol ; GO:0005829 | inferred by curator from GO:0033404 "CR32841, tRNA[Leu], DtL[a], leu-a, AE002787.trna17-LeuCAA, tRNA:L:CAA:AE002787-a, tRNA:leu3:49Fa, CR32840, tRNA[LEU], chr2R.trna76-LeuCAA, tRNA-Leu-CAA-2-1, tRNA:Leu-CAA-2-1, tRNA:L3:49Fa, UUG" - CR32841 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0040239 bc10 bc10 http://flybase.org/reports/FBgn0040239 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "dbc10, CG4867, bc10" IPR009598:Bladder cancer-related BC10 CG4867 27-Aug-18 DroID_v2018_08 Drer\blcap - Cele\Y73E7A.6 Xtro\blcap Mmus\Blcap Hsap\BLCAP viable FBgn0002720 mesA messy A http://flybase.org/reports/FBgn0002720 - gene - - - "messy, mes-A, l(3)mes-1A, mesA" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,visible,partially lethal - majority die,sterile" "head bristle,adult thorax & macrochaeta,anterior scutellar bristle,wing,posterior crossvein" FBgn0017422 anon-70Cb anon-70Cb http://flybase.org/reports/FBgn0017422 - gene - - - "t3, anon-70Cb" - - 27-Aug-18 DroID_v2018_08 - - - - - - embryonic stage && larval stage && pupal stage FBgn0025775 l(2)37Ad lethal (2) 37Ad http://flybase.org/reports/FBgn0025775 - gene - - - "l(2)02660, l(2)02660r, l(2)37Ad" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0033868 S-Lap7 Sperm-Leucylaminopeptidase 7 http://flybase.org/reports/FBgn0033868 protein_coding_gene "aminopeptidase activity ; GO:0004177 | inferred from electronic annotation with InterPro:IPR000819, InterPro:IPR008283, InterPro:IPR011356 metalloexopeptidase activity ; GO:0008235 | inferred from electronic annotation with InterPro:IPR011356 manganese ion binding ; GO:0030145 | inferred from electronic annotation with InterPro:IPR011356" "proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR000819, InterPro:IPR008283 multicellular organism reproduction ; GO:0032504 | inferred from expression pattern" cytoplasm ; GO:0005737 | inferred from electronic annotation with InterPro:IPR011356 extracellular space ; GO:0005615 | inferred from direct assay "CG13340, S-Lap7, S-LAP 7" "IPR000819:Peptidase M17, leucyl aminopeptidase, C-terminal, IPR008283:Peptidase M17, leucyl aminopeptidase, N-terminal, IPR011356:Peptidase M17, leucine aminopeptidase/peptidase B" CG13340 27-Aug-18 DroID_v2018_08 "Drer\zgc:152830, Drer\lap3, Drer\npepl1, Drer\rfwd2" - Cele\lap-1 "Xtro\lap3, Xtro\rfwd2" "Mmus\Rfwd2, Mmus\Npepl1, Mmus\Lap3" "Hsap\LAP3, Hsap\NPEPL1" FBgn0263268 del3 - http://flybase.org/reports/FBgn0263268 gene - gonad development ; GO:0008406 | inferred from mutant phenotype - del3 - - 27-Aug-18 DroID_v2018_08 - - - - - - gonad FBgn0267029 lncRNA:CR45473 - http://flybase.org/reports/FBgn0267029 non_protein_coding_gene - - - CR45473 - CR45473 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0027508 Tnks tankyrase http://flybase.org/reports/FBgn0027508 FBgn0039351 protein_coding_gene scaffold protein binding ; GO:0097110 | inferred from physical interaction with Axn NAD+ ADP-ribosyltransferase activity ; GO:0003950 | inferred from direct assay positive regulation of telomere maintenance via telomerase ; GO:0032212 | inferred from electronic annotation with InterPro:IPR028731 Wnt signaling pathway ; GO:0016055 | inferred from electronic annotation with InterPro:IPR028731 spindle assembly ; GO:0051225 | inferred from electronic annotation with InterPro:IPR028731 protein ADP-ribosylation ; GO:0006471 | inferred from direct assay chaeta development ; GO:0022416 | inferred from genetic interaction with Ssdp inferred from genetic interaction with Chi regulation of proteasome assembly ; GO:0090364 | inferred from direct assay wing disc development ; GO:0035220 | inferred from genetic interaction with Bx - "BcDNA:LD22548, CG17487, CG4719, tankyrase, Dm.pARTb, Tnks, dTNKS, DTNKS, TNKS, Tankyrase, dARTD5, dTANK" "IPR001660:Sterile alpha motif domain, IPR002110:Ankyrin repeat, IPR012317:Poly(ADP-ribose) polymerase, catalytic domain, IPR013761:Sterile alpha motif/pointed domain, IPR020683:Ankyrin repeat-containing domain, IPR028731:Tankyrase-1, IPR015943:WD40/YVTN repeat-like-containing domain" CG4719 27-Aug-18 DroID_v2018_08 "Drer\si:dkey-86e18.2, Drer\ankdd1a, Drer\tnksb, Drer\ank1b, Drer\pidd1, Drer\si:ch73-193i2.2, Drer\ank3a, Drer\psmd10, Drer\ankef1b, Drer\tnksa, Drer\si:ch73-252i11.1, Drer\trpn1, Drer\si:ch211-203b8.6, Drer\ankef1a, Drer\hace1, Drer\ankdd1b, Drer\ank3b, Drer\ank2a" Scer\NAS6 "Cele\F40G9.17, Cele\trp-4, Cele\K02B12.5" "Xtro\ank3, Xtro\LOC100492885, Xtro\tnks2, Xtro\ankdd1a, Xtro\tnks, Xtro\ankef1, Xtro\cat2, Xtro\parp14.3, Xtro\hace1, Xtro\ank1, Xtro\asb7, Xtro\ank2" "Mmus\Asb7, Mmus\Ankrd44, Mmus\Ankrd53, Mmus\Ank2, Mmus\Ank1, Mmus\Ankrd61, Mmus\Ankdd1b, Mmus\Ankef1, Mmus\Hace1, Mmus\Ankrd42, Mmus\Ankdd1a, Mmus\Pidd1, Mmus\Rnasel, Mmus\Ankrd60, Mmus\Tiparp, Mmus\Tnks, Mmus\Ankrd65, Mmus\Tnks2, Mmus\Ank3, Mmus\Psmd10" "Hsap\ANKDD1B, Hsap\ANK2, Hsap\ANKDD1A, Hsap\ANKRD61, Hsap\ANKRD60, Hsap\ASB7, Hsap\ANKRD65, Hsap\ANKRD53, Hsap\ANKEF1, Hsap\TNKS2, Hsap\ANK3, Hsap\PIDD1, Hsap\HACE1, Hsap\TNKS, Hsap\ANK1, Hsap\TIPARP, Hsap\PSMD10, Hsap\RNASEL" viable FBgn0260334 GSd414 - http://flybase.org/reports/FBgn0260334 gene - - - GSd414 - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0010587 l(2)04884 lethal (2) 04884 http://flybase.org/reports/FBgn0010587 - gene - - - l(2)04884 - - 27-Aug-18 DroID_v2018_08 - - - - - - partially lethal - majority die FBgn0036186 CG6071 - http://flybase.org/reports/FBgn0036186 protein_coding_gene peptide binding ; GO:0042277 | inferred from biological aspect of ancestor with PANTHER:PTN000164249 metalloaminopeptidase activity ; GO:0070006 | inferred from biological aspect of ancestor with PANTHER:PTN000164249 zinc ion binding ; GO:0008270 | inferred from biological aspect of ancestor with PANTHER:PTN000164249 multicellular organism reproduction ; GO:0032504 | inferred from expression pattern proteolysis ; GO:0006508 | inferred from biological aspect of ancestor with PANTHER:PTN000164249 peptide catabolic process ; GO:0043171 | inferred from biological aspect of ancestor with PANTHER:PTN000164249 cytoplasm ; GO:0005737 | inferred from biological aspect of ancestor with PANTHER:PTN000164249 extracellular space ; GO:0005615 | inferred from direct assay CG6071 "IPR024571:ERAP1-like C-terminal domain, IPR001930:Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase, IPR014782:Peptidase M1, membrane alanine aminopeptidase, N-terminal" CG6071 27-Aug-18 DroID_v2018_08 "Drer\anpepa, Drer\erap1a, Drer\lnpep, Drer\erap2, Drer\enpep, Drer\erap1b, Drer\npepps, Drer\si:ch211-149p5.1, Drer\si:ch211-198g19.1, Drer\anpepb, Drer\si:ch211-276a23.5, Drer\si:ch211-106j24.1" "Scer\APE2, Scer\AAP1, Scer\TMA108" "Cele\R03G8.4, Cele\AC3.5, Cele\T12E12.6, Cele\Y67D8C.9, Cele\T07F10.1, Cele\T16G12.1, Cele\Y53F4B.20, Cele\VB0395L.1, Cele\mnp-1, Cele\F49B2.6, Cele\pam-1, Cele\R03G8.6, Cele\Y42A5A.1" "Xtro\lnpep, Xtro\lvrn, Xtro\anpep, Xtro\enpep, Xtro\npepps, Xtro\erap1" "Mmus\Anpep, Mmus\Npepps, Mmus\Lvrn, Mmus\Enpep, Mmus\Trhde, Mmus\Erap1, Mmus\Lnpep" "Hsap\ANPEP, Hsap\ERAP1, Hsap\ENPEP, Hsap\ERAP2, Hsap\TRHDE, Hsap\LNPEP, Hsap\NPEPPS, Hsap\LVRN" viable FBgn0000632 fap female abdomen pattern http://flybase.org/reports/FBgn0000632 - gene - - - fap - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,female,recessive,body color defective" "abdominal tergite 6,abdominal tergite 7" FBgn0016702 Ras85D::Src64B Ras85D::Src64B http://flybase.org/reports/FBgn0016702 - engineered_fusion_gene - - - Ras85D::Src64B - - 27-Aug-18 DroID_v2018_08 - - - - - - "photoreceptor cell R7,eye" FBgn0000302 cha chaff http://flybase.org/reports/FBgn0000302 - gene molecular_function ; GO:0003674 | no biological data available embryonic development via the syncytial blastoderm ; GO:0001700 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available cha - - 27-Aug-18 DroID_v2018_08 - - - - - - "female sterile,recessive,lethal - all die before end of embryonic stage,maternal effect,some die during embryonic stage" "embryonic/first instar larval cuticle,maternal effect,embryonic head" FBgn0085673 Su(Ste):CR41533 - http://flybase.org/reports/FBgn0085673 non_protein_coding_gene - - - "CG41533, CR41533, Su(Ste):CR41533, Su(Ste)" - CR41533 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0019623 Crlbp Chemical-sense-related lipophilic-ligand-binding protein http://flybase.org/reports/FBgn0019623 - gene - - - Crlbp - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0069229 gl(2L)343-11 gl(2L)343-11 http://flybase.org/reports/FBgn0069229 gene molecular_function ; GO:0003674 | no biological data available "anterior/posterior axis specification, embryo ; GO:0008595 | inferred from mutant phenotype" cellular_component ; GO:0005575 | no biological data available gl(2L)343-11 - - 27-Aug-18 DroID_v2018_08 - - - - - - "viable,lethal - all die before end of embryonic stage,germline clone,non-rescuable maternal effect,recessive,some die during embryonic stage,maternal effect" "embryonic head,germline clone,maternal effect" FBgn0004938 ABO-YL Abnormal Oocyte on YL http://flybase.org/reports/FBgn0004938 - region - - - "ABO, ABO-YL" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0004023 wrl whirligig http://flybase.org/reports/FBgn0004023 - gene - microtubule-based process ; GO:0007017 | inferred from mutant phenotype sperm axoneme assembly ; GO:0007288 | inferred from mutant phenotype - "nc4, ms(3)nc4, EcRms4, wrl" - - 27-Aug-18 DroID_v2018_08 - - - - - - "male sterile,dominant,recessive,viable" spermatid axoneme FBgn0030621 CG15030 - http://flybase.org/reports/FBgn0030621 protein_coding_gene - - - CG15030 - - 27-Aug-18 DroID_v2018_08 - - - - - - viable DRSC19611 I 1.682582919 -1.125804612 -0.837113938 0.438017978 0.149972023 0.519726808 FBgn0022812 E(faf)E306 Enhancer of faf E306 http://flybase.org/reports/FBgn0022812 - gene - - - E(faf)E306 - - 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0030687 CG17209 - http://flybase.org/reports/FBgn0030687 protein_coding_gene "DNA binding ; GO:0003677 | inferred from electronic annotation with InterPro:IPR000722, InterPro:IPR006592, InterPro:IPR007066, InterPro:IPR007080, InterPro:IPR007081, InterPro:IPR007083 RNA polymerase III activity ; GO:0001056 | contributes_to inferred from biological aspect of ancestor with PANTHER:PTN000453624" "transcription, DNA-templated ; GO:0006351 | inferred from electronic annotation with InterPro:IPR000722, InterPro:IPR006592, InterPro:IPR007066, InterPro:IPR007080, InterPro:IPR007081, InterPro:IPR007083" DNA-directed RNA polymerase III complex ; GO:0005666 | inferred from biological aspect of ancestor with PANTHER:PTN000453624 CG17209 "IPR000722:RNA polymerase, alpha subunit, IPR006592:RNA polymerase, N-terminal, IPR007066:RNA polymerase Rpb1, domain 3, IPR007080:RNA polymerase Rpb1, domain 1, IPR007081:RNA polymerase Rpb1, domain 5, IPR007083:RNA polymerase Rpb1, domain 4" CG17209 27-Aug-18 DroID_v2018_08 "Drer\polr2a, Drer\ubxn7, Drer\polr3a" "Scer\RPO21, Scer\RPO31" Cele\rpc-1 "Xtro\polr3a, Xtro\ubxn7" "Mmus\Polr2a, Mmus\Ubxn7, Mmus\Polr3a" "Hsap\UBXN7, Hsap\POLR3A, Hsap\POLR2A" "visible,partially lethal - majority die,some die during pupal stage" mesothoracic tergum DRSC19766 K -0.301337531 0.160980242 -0.963043534 0.482878275 2.135652684 -0.893814352 FBgn0034076 Jhedup Juvenile hormone esterase duplication http://flybase.org/reports/FBgn0034076 protein_coding_gene carboxylic ester hydrolase activity ; GO:0052689 | inferred from biological aspect of ancestor with PANTHER:PTN000168392 - - "CG8424, Jhedup, JHEdup, JHE" "IPR002018:Carboxylesterase, type B, IPR019819:Carboxylesterase type B, conserved site, IPR019826:Carboxylesterase type B, active site, IPR029058:Alpha/Beta hydrolase fold" CG8424 27-Aug-18 DroID_v2018_08 "Drer\cell, Drer\si:ch211-93f2.1, Drer\nlgn4b, Drer\nlgn4a, Drer\nlgn2b, Drer\cel.1, Drer\nlgn3b, Drer\nlgn1, Drer\ces3, Drer\ces2, Drer\nlgn2a, Drer\nlgn3a" - "Cele\K11G9.3, Cele\T28C12.5, Cele\F07C4.12, Cele\C23H4.2, Cele\C23H4.3, Cele\K11G9.2, Cele\C17H12.4, Cele\E01G6.3, Cele\Y71H2AM.13, Cele\C23H4.4, Cele\F15A8.6, Cele\T02B5.1, Cele\K07C11.4, Cele\ZK994.1, Cele\T28C12.4, Cele\C23H4.7, Cele\C52A10.2, Cele\T02B5.3, Cele\F56C11.6, Cele\F13H6.3, Cele\ZC376.3, Cele\B0238.1, Cele\ZC376.2, Cele\ZC376.1, Cele\T22D1.11, Cele\K11G9.1, Cele\C42D4.2, Cele\C52A10.1, Cele\R173.3, Cele\C01B10.4, Cele\C01B10.10" "Xtro\ces2, Xtro\cel, Xtro\nlgn2, Xtro\nlgn3, Xtro\nlgn4x, Xtro\ces3, Xtro\LOC100494782" "Mmus\Ces2c, Mmus\Ces2f, Mmus\Ces1b, Mmus\Ces2e, Mmus\Ces5a, Mmus\Nlgn3, Mmus\Ces2a, Mmus\Ces2h, Mmus\Ces1c, Mmus\Nlgn2, Mmus\Ces2b, Mmus\Ces3a, Mmus\Ces1e, Mmus\Ces3b, Mmus\Ces4a, Mmus\Cel, Mmus\Ces2g, Mmus\Ces1d, Mmus\Ces1h, Mmus\Nlgn1, Mmus\Ces1f, Mmus\Ces1g" "Hsap\CES4A, Hsap\CEL, Hsap\CES3, Hsap\CES1, Hsap\NLGN4Y, Hsap\NLGN3, Hsap\NLGN2, Hsap\CES2, Hsap\CES5A, Hsap\NLGN1, Hsap\NLGN4X" viable FBgn0053143 CG33143 - http://flybase.org/reports/FBgn0053143 protein_coding_gene - - - "CG4232, CG13509, CG33143, 33143, mdcds_16487" "IPR003961:Fibronectin type III, IPR013783:Immunoglobulin-like fold, IPR032073:Fibronectin type III domain-containing protein 5, C-terminal domain" CG33143 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0085547 CG40971 - http://flybase.org/reports/FBgn0085547 protein_coding_gene - - - CG40971 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0029033 l(2)Q73 lethal (2) Q73 http://flybase.org/reports/FBgn0029033 gene - - - "Q73, l(2)Q73" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0003106 PL(3)sp-W1 Polygenic locus sternopleural W1 http://flybase.org/reports/FBgn0003106 - gene - - - "a, PL(3)sp[W1], PL(3)sp-W1" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0034684 CG13501 - http://flybase.org/reports/FBgn0034684 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG13501 "IPR016024:Armadillo-type fold, IPR011989:Armadillo-like helical" CG13501 27-Aug-18 DroID_v2018_08 Drer\rsph14 - - Xtro\rsph14 Mmus\Rsph14 Hsap\RSPH14 viable FBgn0038683 CG11779 - http://flybase.org/reports/FBgn0038683 protein_coding_gene chaperone binding ; GO:0051087 | inferred from biological aspect of ancestor with PANTHER:PTN000076497 P-P-bond-hydrolysis-driven protein transmembrane transporter activity ; GO:0015450 | inferred from sequence or structural similarity with UniProtKB:O43615 protein import into mitochondrial matrix ; GO:0030150 | inferred from biological aspect of ancestor with PANTHER:PTN000076497 protein targeting to mitochondrion ; GO:0006626 | inferred from sequence or structural similarity with UniProtKB:O43615 cellular response to hypoxia ; GO:0071456 | inferred from mutant phenotype mitochondrial inner membrane presequence translocase complex ; GO:0005744 | inferred from sequence or structural similarity with UniProtKB:O43615 mitochondrial inner membrane ; GO:0005743 | inferred from biological aspect of ancestor with PANTHER:PTN000076497 "BcDNA:GM03811, BEST:GM03811, CG11779, CG117799, GH-18370" "IPR007379:Tim44-like domain, IPR017303:Mitochondrial import inner membrane translocase subunit Tim44, IPR032710:NTF2-like domain" CG11779 27-Aug-18 DroID_v2018_08 Drer\timm44 Scer\TIM44 Cele\tin-44 Xtro\timm44 Mmus\Timm44 Hsap\TIMM44 "viable,fertile,visible,partially lethal - majority die,some die during pupal stage" "eye,trichogen cell,mesothoracic tergum" FBgn0028120 l(3)S060313 lethal (3) S060313 http://flybase.org/reports/FBgn0028120 gene - - - "l(3)S060313, l(3)s001813" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0025840 E(var)915 E(var)915 http://flybase.org/reports/FBgn0025840 - gene - - - "E-915, E(var)915" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0284442 Mcm3 Minichromosome maintenance 3 http://flybase.org/reports/FBgn0284442 protein_coding_gene "DNA binding ; GO:0003677 | inferred from electronic annotation with InterPro:IPR001208, InterPro:IPR008046, InterPro:IPR018525 ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR001208, InterPro:IPR008046, InterPro:IPR018525 3'-5' DNA helicase activity ; GO:0043138 | contributes_to inferred from direct assay" DNA replication initiation ; GO:0006270 | inferred from electronic annotation with InterPro:IPR008046 mushroom body development ; GO:0016319 | inferred from mutant phenotype neuroblast proliferation ; GO:0007405 | inferred from mutant phenotype mitotic G2 DNA damage checkpoint ; GO:0007095 | inferred from mutant phenotype neurogenesis ; GO:0022008 | inferred from mutant phenotype nucleus ; GO:0005634 | inferred from electronic annotation with InterPro:IPR008046 MCM complex ; GO:0042555 | inferred from electronic annotation with InterPro:IPR008046 "mcm3, smu, Mcm3, CG4206, MCM3, DmMcm3, DmMCM3, dMCM3, PCR2, Mcp-PCR2, McM3, DmeMCM3, dMcm3" "IPR033762:MCM OB domain, IPR031327:Mini-chromosome maintenance protein, IPR018525:Mini-chromosome maintenance, conserved site, IPR001208:MCM domain, IPR003593:AAA+ ATPase domain, IPR008046:DNA replication licensing factor Mcm3, IPR012340:Nucleic acid-binding, OB-fold, IPR027417:P-loop containing nucleoside triphosphate hydrolase, IPR027925:MCM N-terminal domain" CG4206 27-Aug-18 DroID_v2018_08 "Drer\mcm3, Drer\mcm3l" Scer\MCM3 Cele\mcm-3 Xtro\mcm3 Mmus\Mcm3 Hsap\MCM3 " adult stage | female , egg stage | unfertilized egg , embryonic stage | 0-4 hr , embryonic stage | stage 11-12 " " unfertilized egg

, embryonic central nervous system

" "radiation sensitive,lethal,neuroanatomy defective" "embryonic/larval neuroblast,ganglion mother cell" FBgn0026077 Gasp Gasp http://flybase.org/reports/FBgn0026077 FBgn0026290 protein_coding_gene chitin binding ; GO:0008061 | inferred from electronic annotation with InterPro:IPR002557 chitin binding ; GO:0008061 | inferred from reviewed computational analysis "chitin metabolic process ; GO:0006030 | inferred from electronic annotation with InterPro:IPR002557 chitin-based embryonic cuticle biosynthetic process ; GO:0008362 | inferred from mutant phenotype regulation of tube size, open tracheal system ; GO:0035151 | inferred from mutant phenotype regulation of multicellular organism growth ; GO:0040014 | inferred from mutant phenotype" extracellular space ; GO:0005615 | inferred from direct assay "gasp, gammaBert27, anon-EST:ParkEST180, CG10287, Gasp, obst-C, 2A12" IPR002557:Chitin binding domain CG10287 27-Aug-18 DroID_v2018_08 - - "Cele\R02F2.4, Cele\dct-9, Cele\cbd-1, Cele\cpg-2" - - - viable FBgn0001983 wor worniu http://flybase.org/reports/FBgn0001983 - protein_coding_gene "nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR013087 transcription factor activity, sequence-specific DNA binding ; GO:0003700 | inferred from sequence or structural similarity with esg inferred from sequence or structural similarity with sna" "dendrite morphogenesis ; GO:0048813 | inferred from mutant phenotype lateral inhibition ; GO:0046331 | inferred from mutant phenotype regulation of transcription, DNA-templated ; GO:0006355 | inferred from sequence or structural similarity brain development ; GO:0007420 | inferred from mutant phenotype ventral cord development ; GO:0007419 | inferred from mutant phenotype central nervous system development ; GO:0007417 | inferred from mutant phenotype positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 | inferred from mutant phenotype asymmetric neuroblast division ; GO:0055059 | inferred from genetic interaction with esg, sna" nucleus ; GO:0005634 | inferred from sequence or structural similarity "Wor, l(2)35Da, BG:DS03023.1, l(2)br35, l35Da, br35, CG4158, wor" IPR013087:Zinc finger C2H2-type CG4158 27-Aug-18 DroID_v2018_08 "Drer\scrt1b, Drer\snai1b, Drer\scrt2, Drer\si:dkeyp-113d7.10, Drer\snai3, Drer\snai2, Drer\snai1a, Drer\scrt1a" "Scer\RPH1, Scer\AZF1" Cele\snai-1 "Xtro\wt1, Xtro\snai1, Xtro\snai2" "Mmus\Scrt2, Mmus\Scrt1, Mmus\Snai3, Mmus\Zfp128, Mmus\Snai1, Mmus\Snai2" "Hsap\ZNF8, Hsap\SNAI3, Hsap\SNAI2, Hsap\SNAI1, Hsap\ZNF461, Hsap\SCRT1, Hsap\SCRT2" " embryonic stage | stage >=8 , embryonic stage | stage >=13 , embryonic stage | stage >=9 " " procephalic neurogenic region

, embryonic brain

, ventral nerve cord

, neuroblast

" "neuroanatomy defective,partially lethal - majority die,lethal,lethal - all die before end of embryonic stage,recessive,some die during embryonic stage,viable,visible" "ventral nerve cord,denticle belt,embryonic/larval brain,dorsal multidendritic neuron ddaE & dendrite,abdominal dorsal multidendritic neuron ddaE & dendrite,chaeta,supernumerary" FBgn0010137 l(2)62B10 lethal (2) of Spiess 62B10 http://flybase.org/reports/FBgn0010137 - gene - - - l(2)62B10 - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0036575 CG5157 - http://flybase.org/reports/FBgn0036575 protein_coding_gene heme binding ; GO:0020037 | inferred from electronic annotation with InterPro:IPR018506 - - CG5157 "IPR001199:Cytochrome b5-like heme/steroid binding domain, IPR018506:Cytochrome b5, heme-binding site" CG5157 27-Aug-18 DroID_v2018_08 "Drer\fads2, Drer\cyb5b, Drer\cyb5a" "Scer\CYB2, Scer\CYB5, Scer\SCS7, Scer\OLE1" "Cele\cytb-5.1, Cele\cytb-5.2" "Xtro\cyb5b, Xtro\cyb5a" "Mmus\Cyb5a, Mmus\Cyb5d1, Mmus\Fads1, Mmus\Cyb5b" "Hsap\FADS2, Hsap\CYB5B, Hsap\CYB5A" viable FBgn0058154 CG40154 - http://flybase.org/reports/FBgn0058154 protein_coding_gene - - - CG40154 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0034502 CG13871 - http://flybase.org/reports/FBgn0034502 protein_coding_gene - - - CG13871 - CG13871 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0038647 CG14302 - http://flybase.org/reports/FBgn0038647 protein_coding_gene - - - "BcDNA:LP02994, CG14302" - CG14302 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0263378 asRNA:CR43430 - http://flybase.org/reports/FBgn0263378 non_protein_coding_gene - - - CR43430 - CR43430 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0022158 l(2)k05722 lethal (2) k05722 http://flybase.org/reports/FBgn0022158 - gene - - - l(2)k05722 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0267443 lncRNA:CR45793 - http://flybase.org/reports/FBgn0267443 non_protein_coding_gene - - - "CR45793, Mgn095159" - CR45793 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0067870 Mod(Prat:bw)3-5 Mod(Prat:bw)3-5 http://flybase.org/reports/FBgn0067870 gene - - - "Mod-3-5, Mod(Prat:bw)3-5" - - 27-Aug-18 DroID_v2018_08 - - - - - - enhancer of variegation FBgn0032387 CG16965 - http://flybase.org/reports/FBgn0032387 protein_coding_gene "catalytic activity ; GO:0003824 | inferred from electronic annotation with InterPro:IPR005195, InterPro:IPR008928, InterPro:IPR012341" carbohydrate metabolic process ; GO:0005975 | inferred from electronic annotation with InterPro:IPR005195 - CG16965 "IPR005195:Glycoside hydrolase, family 65, central catalytic, IPR008928:Six-hairpin glycosidase-like" CG16965 27-Aug-18 DroID_v2018_08 Drer\pgghg Scer\ATH1 - Xtro\athl1 Mmus\Pgghg Hsap\PGGHG viable FBgn0043557 Su(ro[DOM])2014 Su(ro[DOM])2014 http://flybase.org/reports/FBgn0043557 gene molecular_function ; GO:0003674 | no biological data available compound eye morphogenesis ; GO:0001745 | inferred from genetic interaction with ro cellular_component ; GO:0005575 | no biological data available Su(ro[DOM])2014 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0062643 EP707 EP707 http://flybase.org/reports/FBgn0062643 gene - - - "EP(3)0707, EP707" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0082330 HM813 HM813 http://flybase.org/reports/FBgn0082330 gene - - - HM813 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0002388 l(3)93Dd lethal (3) 93Dd http://flybase.org/reports/FBgn0002388 - gene - - - "er9, l(3)er9, l(3)93Dd" - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,recessive,lethal" eye FBgn0002429 l(3)F55 lethal (3) F55 http://flybase.org/reports/FBgn0002429 - gene - - - "l(3)55, l(3)F55" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of larval stage,recessive,some die during larval stage" wing FBgn0263382 lncRNA:CR43434 - http://flybase.org/reports/FBgn0263382 non_protein_coding_gene - - - CR43434 - CR43434 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0261523 CG42658 - http://flybase.org/reports/FBgn0261523 protein_coding_gene - - endoplasmic reticulum membrane ; GO:0005789 | inferred from electronic annotation with InterPro:IPR016763 CG42658 "IPR016763:Vesicle-associated membrane-protein-associated protein, IPR013783:Immunoglobulin-like fold, IPR008962:PapD-like, IPR000535:Major sperm protein (MSP) domain" CG42658 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0069304 X-86-9 X-86-9 http://flybase.org/reports/FBgn0069304 gene molecular_function ; GO:0003674 | no biological data available morphogenesis of embryonic epithelium ; GO:0016331 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available X-86-9 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of embryonic stage,germline clone,non-rescuable maternal effect,recessive,some die during embryonic stage" "embryonic/first instar larval cuticle,germline clone,maternal effect,filzkorper" FBgn0022970 snRNPA snRNPA http://flybase.org/reports/FBgn0022970 - gene - - nucleus ; GO:0005634 | inferred from direct assay small nuclear ribonucleoprotein complex ; GO:0030532 | inferred from direct assay "A, snRNPA" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0015488 l(2)46Cl lethal (2) 46Cl http://flybase.org/reports/FBgn0015488 - gene - - - "T, l(2)46Cl" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive,lethal - all die before end of embryonic stage,some die during embryonic stage" FBgn0086913 Rab26 Rab26 http://flybase.org/reports/FBgn0086913 protein_coding_gene GTP binding ; GO:0005525 | inferred from sequence or structural similarity with UniProtKB:P51156 GTPase activity ; GO:0003924 | inferred from sequence or structural similarity with Rab11 vesicle docking involved in exocytosis ; GO:0006904 | inferred from biological aspect of ancestor with PANTHER:PTN000635132 Rab protein signal transduction ; GO:0032482 | inferred from sequence or structural similarity with Rab11 vesicle-mediated transport ; GO:0016192 | inferred from sequence or structural similarity with Rab11 protein localization to plasma membrane ; GO:0072659 | inferred from biological aspect of ancestor with PANTHER:PTN000635134 protein secretion ; GO:0009306 | inferred from biological aspect of ancestor with PANTHER:PTN000635132 regulation of exocytosis ; GO:0017157 | inferred from sequence or structural similarity with UniProtKB:P51156 vesicle ; GO:0031982 | inferred from sequence or structural similarity with Rab11 intrinsic component of plasma membrane ; GO:0031226 | inferred from sequence or structural similarity with UniProtKB:P51156 recycling endosome ; GO:0055037 | inferred from direct assay synaptic vesicle ; GO:0008021 | inferred from biological aspect of ancestor with PANTHER:PTN001530779 plasma membrane ; GO:0005886 | inferred from biological aspect of ancestor with PANTHER:PTN000635134 synapse ; GO:0045202 | inferred from direct assay "rab26, AAF51708, DmRab26, CG7605, Rab26, CG32439, CG34410, Q8IPT6, Q9VP48" "IPR027417:P-loop containing nucleoside triphosphate hydrolase, IPR001806:Small GTPase superfamily, IPR005225:Small GTP-binding protein domain" CG34410 27-Aug-18 DroID_v2018_08 Drer\zgc:112183 Scer\SEC4 Cele\rab-37 "Xtro\rab26, Xtro\rab37" "Mmus\Rab37, Mmus\Rab26" "Hsap\RAB37, Hsap\RAB26" viable FBgn0082355 HM298 HM298 http://flybase.org/reports/FBgn0082355 gene - - - HM298 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0020881 als alae sublatae http://flybase.org/reports/FBgn0020881 - gene - - - "als, Mps1" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0016809 l(1)L10 lethal (1) L10 http://flybase.org/reports/FBgn0016809 - gene - - - "l(1)L10, L10" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0051238 CG31238 - http://flybase.org/reports/FBgn0051238 protein_coding_gene - - - CG31238 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0000564 Eh Eclosion hormone http://flybase.org/reports/FBgn0000564 FBgn0026855 protein_coding_gene ecdysis-triggering hormone activity ; GO:0008255 | inferred from electronic annotation with InterPro:IPR006825 neuropeptide hormone activity ; GO:0005184 | traceable author statement eclosion hormone activity ; GO:0008031 | non-traceable author statement eclosion hormone activity ; GO:0008031 | inferred from sequence or structural similarity "neuropeptide signaling pathway ; GO:0007218 | inferred from electronic annotation with InterPro:IPR006825 eclosion ; GO:0007562 | traceable author statement regulation of eclosion ; GO:0007563 | inferred from sequence or structural similarity neuropeptide signaling pathway ; GO:0007218 | traceable author statement ecdysis, chitin-based cuticle ; GO:0018990 | inferred from mutant phenotype" extracellular space ; GO:0005615 | inferred from sequence model "EH, Drm-EH, eh, EHAB, DMEHAB, CG5400, Eh" IPR006825:Eclosion hormone CG5400 27-Aug-18 DroID_v2018_08 - - "Cele\clec-251, Cele\F11D11.6, Cele\clec-253, Cele\clec-255" - - - FBgn0030191 CG15306 - http://flybase.org/reports/FBgn0030191 protein_coding_gene microtubule binding ; GO:0008017 | inferred from electronic annotation with InterPro:IPR027328 molecular_function ; GO:0003674 | no biological data available positive regulation of JAK-STAT cascade ; GO:0046427 | inferred from mutant phenotype - CG15306 "IPR001715:Calponin homology domain, IPR027328:Microtubule-associated protein RP/EB" CG15306 27-Aug-18 DroID_v2018_08 "Drer\mapre2, Drer\mapre1a, Drer\mapre3b, Drer\mapre3a, Drer\mapre1b" "Scer\CHS5, Scer\BIM1" "Cele\ebp-1, Cele\ebp-2, Cele\ebp-3" Xtro\mapre1 "Mmus\Dmp1, Mmus\Mapre3, Mmus\Mapre2, Mmus\Mapre1" "Hsap\MAPRE3, Hsap\DMP1, Hsap\MAPRE1, Hsap\MAPRE2" viable FBgn0035170 dpr20 defective proboscis extension response 20 http://flybase.org/reports/FBgn0035170 protein_coding_gene molecular_function ; GO:0003674 | no biological data available sensory perception of chemical stimulus ; GO:0007606 | inferred from sequence or structural similarity with dpr1 synapse organization ; GO:0050808 | inferred from expression pattern integral component of plasma membrane ; GO:0005887 | inferred from sequence model "CG12191, Dpr-20, CT9818, dpr20, Dpr20" "IPR003598:Immunoglobulin subtype 2, IPR003599:Immunoglobulin subtype, IPR007110:Immunoglobulin-like domain, IPR013106:Immunoglobulin V-set domain, IPR013783:Immunoglobulin-like fold, IPR013151:Immunoglobulin" CG12191 27-Aug-18 DroID_v2018_08 "Drer\LOC100333196, Drer\LOC101885444, Drer\si:ch211-264f5.6, Drer\si:dkey-65b12.12, Drer\nadl1.1" - Cele\zig-8 "Xtro\obsl1, Xtro\nfasc" - - viable FBgn0004186 snRNA:U1:95Cb small nuclear RNA U1 at 95Cb http://flybase.org/reports/FBgn0004186 "FBgn0003915, FBgn0003918" snRNA_gene - "mRNA splicing, via spliceosome ; GO:0000398 | inferred from sequence or structural similarity" U1 snRNP ; GO:0005685 | inferred from sequence or structural similarity "U1, U1 snRNA, U1a-95Cb, U1-95.2, U1snRNA, K5, snRNA:U1, snRNA-U1-95.2, U1snRNA95Cb, CR32866, snRNA:U1:95Cb, U1:95Cb, snRNA:U1:95CB, U1-95Cb, U1:95C, 95C U1" - CR32866 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0265010 Ms(3)88C Male sterile (3) 88C http://flybase.org/reports/FBgn0265010 gene - - - Ms(3)88C - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0084325 su(eas)13 su(eas)13 http://flybase.org/reports/FBgn0084325 gene - - - su(eas)13 - - 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0011661 Moe Moesin http://flybase.org/reports/FBgn0011661 "FBgn0013950, FBgn0014345, FBgn0026689, FBgn0027218, FBgn0028282, FBgn0028289, FBgn0066841, FBgn0066842, FBgn0066843, FBgn0066844" protein_coding_gene "phosphatidylinositol-4,5-bisphosphate binding ; GO:0005546 | inferred from direct assay actin binding ; GO:0003779 | non-traceable author statement actin binding ; GO:0003779 | inferred from direct assay protein binding ; GO:0005515 | inferred from physical interaction with Mer cytoskeletal protein binding ; GO:0008092 | inferred from sequence or structural similarity protein binding ; GO:0005515 | inferred from physical interaction with conu microtubule binding ; GO:0008017 | inferred from mutant phenotype" "regulation of cell shape ; GO:0008360 | inferred from mutant phenotype positive regulation of mitotic spindle elongation ; GO:1902846 | inferred from mutant phenotype pole plasm protein localization ; GO:0007318 | traceable author statement establishment or maintenance of apical/basal cell polarity ; GO:0035088 | traceable author statement microtubule anchoring ; GO:0034453 | inferred from mutant phenotype positive regulation of endocytosis ; GO:0045807 | inferred from mutant phenotype cytoskeleton organization ; GO:0007010 | traceable author statement establishment or maintenance of polarity of larval imaginal disc epithelium ; GO:0016336 | inferred from mutant phenotype establishment or maintenance of epithelial cell apical/basal polarity ; GO:0045197 | inferred from mutant phenotype olfactory behavior ; GO:0042048 | inferred from mutant phenotype anterior/posterior pattern specification ; GO:0009952 | traceable author statement cortical actin cytoskeleton organization ; GO:0030866 | inferred from mutant phenotype lumen formation, open tracheal system ; GO:0035149 | inferred from mutant phenotype male courtship behavior, veined wing generated song production ; GO:0045433 | inferred from mutant phenotype actin filament-based process ; GO:0030029 | non-traceable author statement eye photoreceptor cell development ; GO:0042462 | traceable author statement determination of left/right symmetry ; GO:0007368 | inferred from mutant phenotype rhabdomere membrane biogenesis ; GO:0045313 | inferred from mutant phenotype cortical microtubule organization ; GO:0043622 | inferred from mutant phenotype pole plasm assembly ; GO:0007315 | traceable author statement oocyte anterior/posterior axis specification ; GO:0007314 | inferred from mutant phenotype morphogenesis of an epithelium ; GO:0002009 | traceable author statement regulation of actin cytoskeleton organization ; GO:0032956 | inferred from mutant phenotype protein localization ; GO:0008104 | traceable author statement rhabdomere development ; GO:0042052 | inferred from mutant phenotype establishment or maintenance of epithelial cell apical/basal polarity ; GO:0045197 | inferred from direct assay positive regulation of cell proliferation ; GO:0008284 | inferred from genetic interaction with conu photoreceptor cell axon guidance ; GO:0072499 | inferred from mutant phenotype regulation of membrane potential in photoreceptor cell ; GO:0016057 | inferred from direct assay actin cytoskeleton organization ; GO:0030036 | inferred from mutant phenotype" "extrinsic component of membrane ; GO:0019898 | inferred from electronic annotation with InterPro:IPR000798, InterPro:IPR011174, InterPro:IPR011259 cytosol ; GO:0005829 | inferred from direct assay plasma membrane ; GO:0005886 | inferred from direct assay cytoplasm ; GO:0005737 | colocalizes_with inferred from direct assay nucleus ; GO:0005634 | colocalizes_with inferred from direct assay adherens junction ; GO:0005912 | inferred from direct assay actin cytoskeleton ; GO:0015629 | colocalizes_with inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay cytoplasm ; GO:0005737 | non-traceable author statement spindle ; GO:0005819 | colocalizes_with inferred from direct assay subapical complex ; GO:0035003 | traceable author statement actin filament ; GO:0005884 | colocalizes_with inferred from direct assay cell cortex ; GO:0005938 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay plasma membrane ; GO:0005886 | non-traceable author statement mitotic spindle midzone ; GO:1990023 | inferred from direct assay fusome ; GO:0045169 | NOT inferred from direct assay cleavage furrow ; GO:0032154 | inferred from direct assay apical plasma membrane ; GO:0016324 | inferred from direct assay" "Moe, moe, Dmoe, ERM, CG10701, EMR1, moesin/ezrin/radixin homolog mRNA, l(1)G0415, l(1)G0404, l(1)G0323, l(1)G0067, D17, Emr1, anon-WO03040301.161, anon-WO03040301.159, anon-WO03040301.157, anon-WO03040301.155, dMoe, Moes, gma, moesin, DMoe, Moesin" "IPR000299:FERM domain, IPR000798:Ezrin/radixin/moesin-like, IPR008954:Moesin tail domain, IPR011174:Ezrin/radixin/moesin, IPR011259:Ezrin/radixin/moesin, C-terminal, IPR011993:PH domain-like, IPR014352:FERM/acyl-CoA-binding protein, 3-helical bundle, IPR018979:FERM, N-terminal, IPR018980:FERM, C-terminal PH-like domain, IPR019747:FERM conserved site, IPR019748:FERM central domain, IPR019749:Band 4.1 domain, IPR029071:Ubiquitin-related domain" CG10701 27-Aug-18 DroID_v2018_08 "Drer\ezrb, Drer\nf2b, Drer\zgc:153953, Drer\nf2a, Drer\frmd4bb, Drer\ccdc120, Drer\si:ch211-163l21.4, Drer\msnb, Drer\ezra, Drer\si:ch211-220f12.1, Drer\si:ch211-169p10.1, Drer\msna" - "Cele\erm-1, Cele\nfm-1" "Xtro\ezr, Xtro\rdx, Xtro\msn, Xtro\nf2, Xtro\frmd4a, Xtro\frmd4b" "Mmus\Ezr, Mmus\Msn, Mmus\Ccdc120, Mmus\Nf2, Mmus\5730559C18Rik, Mmus\Rdx, Mmus\Frmd4b, Mmus\Frmd4a" "Hsap\EZR, Hsap\C1orf106, Hsap\NF2, Hsap\RDX, Hsap\FRMD4A, Hsap\FRMD4B, Hsap\CCDC120, Hsap\MSN" pupal stage mesothoracic bristle

"viable,smell perception defective,increased cell death,visible,lethal - all die before end of first instar larval stage,some die during first instar larval stage,partially lethal - majority die,somatic clone,song defective,lethal,lethal - all die before end of larval stage,some die during larval stage,neuroanatomy defective,developmental rate defective,recessive,size defective,lethal - all die before end of pupal stage,some die during pupal stage,lethal - all die before end of P-stage,some die during pharate adult stage,male,female,fertile" "rhabdomere & actin filament, with MoedsRNA.327-775.UAS, hs.PB,rhabdomere & actin filament, with MoedsRNA.327-775.UAS, GMR.PF,photoreceptor cell,wing vein,wing,wing disc,wing hinge,rhabdomere & actin filament, with MoedsRNA.818-1326.UAS, hs.PB,rhabdomere & actin filament, with MoedsRNA.818-1326.UAS, GMR.PF,spindleC587,cyst progenitor cell,wing disc | third instar larval stage,1st posterior cell,wing blade,eye,somatic clone | third instar larval stage,germline cell,wing vein L3,rhabdomere & microvillushs.PB,rhabdomere & plasma membrane | apicalhs.PB,rhabdomere & cytoskeleton | apicalhs.PB,lamina plexus | third instar larval stage,medulla | third instar larval stage,oocyte & cytoskeleton[-],germline cell | embryonic stage,oocyte & cytoskeleton,imaginal disc,medulla,photoreceptor cell R2,photoreceptor cell R3,photoreceptor cell R4,photoreceptor cell R5,photoreceptor cell R8,somatic clone,lamina plexus,embryonic abdominal segment,non-rescuable maternal effect,embryonic/first instar larval cuticle,pole cell,rhabdomere & plasma membrane | apical | somatic clone,rhabdomere & actin filament | somatic clone,basal lamina & dorsal mesothoracic disc & third instar larva,ommatidium,oocyte & actin filament,nurse cell & actin filament,embryonic/larval midgut primordium,embryonic hindgut,presumptive embryonic salivary gland,retina,dorsal trunk primordium,oocyte & actin filament | ectopicnos.UTR.THsimVP16,nurse cell & actin filamentnos.UTR.THsimVP16,nurse cell & actin filamentMoe-PG26,cell non-autonomous | third instar larval stage,cell autonomous | third instar larval stage" FBgn0003093 Pkc98E Protein C kinase 98E http://flybase.org/reports/FBgn0003093 FBgn0005692 protein_coding_gene "protein kinase C activity ; GO:0004697 | inferred from electronic annotation with InterPro:IPR014376 ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR000961, InterPro:IPR002290, InterPro:IPR017441, InterPro:IPR017892 protein kinase C activity ; GO:0004697 | inferred from sequence or structural similarity protein serine/threonine kinase activity ; GO:0004674 | non-traceable author statement protein serine/threonine kinase activity ; GO:0004674 | inferred from biological aspect of ancestor with PANTHER:PTN000683254" peptidyl-serine phosphorylation ; GO:0018105 | inferred from biological aspect of ancestor with PANTHER:PTN000683254 neuron projection morphogenesis ; GO:0048812 | inferred from mutant phenotype Golgi organization ; GO:0007030 | inferred from mutant phenotype lipid particle organization ; GO:0034389 | inferred from mutant phenotype long-term memory ; GO:0007616 | inferred from mutant phenotype response to ethanol ; GO:0045471 | inferred from direct assay positive regulation of multicellular organism growth ; GO:0040018 | inferred from mutant phenotype I-kappaB phosphorylation ; GO:0007252 | inferred from mutant phenotype positive regulation of peptide hormone secretion ; GO:0090277 | inferred from mutant phenotype protein phosphorylation ; GO:0006468 | inferred from sequence or structural similarity protein phosphorylation ; GO:0006468 | non-traceable author statement dorsal/ventral axis specification ; GO:0009950 | inferred from mutant phenotype negative regulation of cell proliferation ; GO:0008285 | inferred from mutant phenotype intracellular ; GO:0005622 | inferred from biological aspect of ancestor with PANTHER:PTN000683254 plasma membrane ; GO:0005886 | inferred from sequence or structural similarity with inaC "PKC-98F, PKC, PKC 98F, CG1954, 98F, dPKC98F, Dpkc3, PKC d98F, nPKC, Pkc3, Nc98F, Pkc98E, PKC98C, PKC98E, PK-C" "IPR000719:Protein kinase domain, IPR000961:AGC-kinase, C-terminal, IPR002219:Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, IPR008271:Serine/threonine-protein kinase, active site, IPR011009:Protein kinase-like domain, IPR014376:Protein kinase C, delta/epsilon/eta/theta types, IPR017441:Protein kinase, ATP binding site, IPR017892:Protein kinase, C-terminal, IPR020454:Diacylglycerol/phorbol-ester binding, IPR034669:Novel protein kinase C epsilon, catalytic domain, IPR000008:C2 domain" CG1954 27-Aug-18 DroID_v2018_08 "Drer\pkn1a, Drer\si:ch73-374l24.1, Drer\prkcq, Drer\zgc:153916, Drer\prkcda, Drer\pimr112, Drer\sgk494a, Drer\prkcea, Drer\prkcg, Drer\prkcbb, Drer\pkn3, Drer\si:ch211-14c7.2, Drer\sgk494b, Drer\pkn1b, Drer\prkchb, Drer\prkca, Drer\prkceb, Drer\prkcha, Drer\pkn2" "Scer\DUN1, Scer\PKC1" "Cele\cam-1, Cele\pkc-1, Cele\pkn-1, Cele\tpa-1, Cele\pkc-2" "Xtro\prkcq, Xtro\prkcb, Xtro\pkn3, Xtro\gpha2, Xtro\prkcd, Xtro\prkce, Xtro\prkca, Xtro\tnfrsf1a, Xtro\prkch, Xtro\LOC100493742, Xtro\prkcg, Xtro\pkn1" "Mmus\Prkcq, Mmus\Sprr1b, Mmus\Pkn1, Mmus\Gm5113, Mmus\Pkn2, Mmus\Prkch, Mmus\Prkcd, Mmus\Prkcg, Mmus\Prx, Mmus\Prkca, Mmus\Prkce, Mmus\Prkcb, Mmus\D130040H23Rik, Mmus\Sprr1a, Mmus\Pkn3, Mmus\BC030499" "Hsap\SGK494, Hsap\PRKCD, Hsap\PRKCB, Hsap\PKN3, Hsap\PRKCQ, Hsap\PRKCH, Hsap\PRX, Hsap\PKN1, Hsap\PKN2, Hsap\PRKCE, Hsap\PRKCG, Hsap\PRKCA" " larval stage | second instar , larval stage | third instar , embryonic stage , adult stage , larval stage | first instar , pupal stage " " cell body &&of adult brain

, head

" "chemical resistant,neuroanatomy defective,memory defective,viable" "denticle,ectopic,filzkorper,embryonic head,embryonic/first instar larval cuticle,embryonic/larval central nervous system" FBgn0013733 shot short stop http://flybase.org/reports/FBgn0013733 "FBgn0014183, FBgn0015972, FBgn0020296, FBgn0021837, FBgn0021937, FBgn0022152, FBgn0022170, FBgn0022208, FBgn0022230" protein_coding_gene microtubule binding ; GO:0008017 | inferred from electronic annotation with InterPro:IPR003108 calcium ion binding ; GO:0005509 | inferred from electronic annotation with InterPro:IPR002048 microtubule binding ; GO:0008017 | traceable author statement actin binding ; GO:0003779 | inferred from sequence or structural similarity protein binding ; GO:0005515 | inferred from physical interaction with kra cytoskeletal protein binding ; GO:0008092 | inferred from sequence or structural similarity actin binding ; GO:0003779 | traceable author statement protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:A1Z6P3 inferred from physical interaction with UniProtKB:Q8T3Y0 "negative regulation of microtubule depolymerization ; GO:0007026 | inferred from mutant phenotype open tracheal system development ; GO:0007424 | traceable author statement lumen formation, open tracheal system ; GO:0035149 | inferred from mutant phenotype dendrite morphogenesis ; GO:0048813 | traceable author statement branch fusion, open tracheal system ; GO:0035147 | inferred from expression pattern muscle attachment ; GO:0016203 | traceable author statement axonogenesis ; GO:0007409 | inferred from mutant phenotype dendrite morphogenesis ; GO:0048813 | inferred from mutant phenotype microtubule cytoskeleton organization ; GO:0000226 | traceable author statement axonogenesis ; GO:0007409 | traceable author statement mushroom body development ; GO:0016319 | inferred from mutant phenotype open tracheal system development ; GO:0007424 | inferred from mutant phenotype apposition of dorsal and ventral imaginal disc-derived wing surfaces ; GO:0007475 | traceable author statement branch fusion, open tracheal system ; GO:0035147 | traceable author statement sensory organ development ; GO:0007423 | traceable author statement oocyte fate determination ; GO:0030716 | inferred from mutant phenotype branch fusion, open tracheal system ; GO:0035147 | inferred from mutant phenotype determination of muscle attachment site ; GO:0016204 | traceable author statement actin cytoskeleton organization ; GO:0030036 | traceable author statement axon midline choice point recognition ; GO:0016199 | inferred from mutant phenotype microtubule-based process ; GO:0007017 | non-traceable author statement microtubule cytoskeleton organization ; GO:0000226 | inferred from mutant phenotype positive regulation of filopodium assembly ; GO:0051491 | inferred from mutant phenotype inferred from genetic interaction with kra microtubule-based process ; GO:0007017 | inferred from direct assay microtubule bundle formation ; GO:0001578 | inferred from mutant phenotype regulation of axon extension ; GO:0030516 | inferred from mutant phenotype positive regulation of axon extension ; GO:0045773 | inferred from mutant phenotype" cytoplasm ; GO:0005737 | inferred from direct assay growth cone ; GO:0030426 | inferred from direct assay adherens junction ; GO:0005912 | traceable author statement cytoskeleton ; GO:0005856 | non-traceable author statement muscle tendon junction ; GO:0005927 | inferred from direct assay fusome ; GO:0045169 | inferred from direct assay microtubule ; GO:0005874 | traceable author statement adherens junction ; GO:0005912 | inferred from direct assay microtubule plus-end ; GO:0035371 | inferred from direct assay astral microtubule ; GO:0000235 | inferred from direct assay axonal growth cone ; GO:0044295 | inferred from direct assay filopodium ; GO:0030175 | inferred from direct assay microtubule ; GO:0005874 | inferred from direct assay "shot, kakp, kak, CG18076, shortstop/kakapo, Shot, grv, l(2)k04204, l(2)k03010, kop, Grv, 42/4, l(2)k10821, l(2)k05821, l(2)k05434, l(2)k15606, l(2)CA4, CG18637, Su(Mir)1" "IPR018159:Spectrin/alpha-actinin, IPR018247:EF-Hand 1, calcium-binding site, IPR001101:Plectin repeat, IPR001589:Actinin-type actin-binding domain, conserved site, IPR001715:Calponin homology domain, IPR002017:Spectrin repeat, IPR002048:EF-hand domain, IPR003108:Gas2-related domain, IPR011992:EF-hand domain pair, IPR001452:SH3 domain" CG18076 27-Aug-18 DroID_v2018_08 "Drer\eppk1, Drer\macf1a, Drer\si:ch211-137a8.2, Drer\syne1b, Drer\evplb, Drer\zgc:100997, Drer\dspa, Drer\syne2b, Drer\wu:fi04e12, Drer\gas2b, Drer\syne1a, Drer\dst, Drer\evpla, Drer\ppl, Drer\pleca, Drer\si:ch211-165e15.1" - Cele\vab-10 "Xtro\plec, Xtro\syne1, Xtro\macf1, Xtro\eppk1, Xtro\dst, Xtro\gas2l2, Xtro\syne2, Xtro\ppl, Xtro\evpl" "Mmus\Smtnl2, Mmus\Dst, Mmus\Clmn, Mmus\Ppl, Mmus\Syne2, Mmus\Macf1, Mmus\Plec, Mmus\Evpl, Mmus\Dsp, Mmus\Syne1, Mmus\Smtnl1" "Hsap\EPPK1, Hsap\PLEC, Hsap\EVPL, Hsap\MACF1, Hsap\SYNE1, Hsap\DSP, Hsap\EVPLL, Hsap\SYNE3, Hsap\PPL, Hsap\SYNE2, Hsap\DST, Hsap\GAS2L1, Hsap\GAS2L2, Hsap\CLMN, Hsap\KIAA0754" " embryonic stage , embryonic stage | stage >=13 , embryonic stage | stage >=11 , embryonic stage | stage 16 " " muscle attachment site

, embryonic peripheral nervous system

, epidermis

, embryonic central nervous system

, organism | segmentally repeated

" " embryonic stage | stage 16 , larval stage | third instar , embryonic stage , embryonic stage | stage >=14 , embryonic stage | stage 12-17 " " embryonic/larval proventriculus

, tendon cell

, scolopidium

, sensory neuron

, muscle attachment site

, epidermis

, chordotonal organ

, neuron

, embryonic/larval pharynx

, intersegmental nerve

" "lethal,recessive,neuroanatomy defective,paralytic,lethal - all die before end of embryonic stage,some die during embryonic stage,decreased cell number,somatic clone,germline clone,visible,lethal - all die before end of larval stage,some die during larval stage" "imaginal disc,chordotonal organ,lateral,scolopidial dendrite,extended germ band embryo,dorsal closure embryo,embryonic epidermis,dendrite & motor neuron | embryonic stage,axon & motor neuron | embryonic stage,neuron,microtubuleMK1),dendrite | dorsal | embryonic stage,presumptive embryonic/larval peripheral nervous system,dorsal,NMJ bouton,supernumerary,supernumerary | third instar larval stage,segmental nerve,RP3 motor neuron,embryonic/larval somatic muscle,embryonic/first instar larval cuticle,muscle attachment site,neuromuscular junction | embryonic stage,embryonic/larval mushroom body,somatic clone,lateral trunk primordium,intersegmental nerve,oocyte,egg chamber & follicle cell | somatic clone,mushroom body & axon,synapse & neuromuscular junction,chordotonal organ & axon | lateral,longitudinal connective,sensory neuron,ovary,germline clone,nurse cell,ectopic,microtubule & ovary | germ-line clone,centrosome & ovary | germ-line clone,axon & pCC neuron,abdominal segmental nerve,embryonic/larval dorsal anastomosis,dorsal trunk primordium,calyx of adult mushroom body,axonMK1),filopodiumMK1),wing,larva,proventriculus inner layer primordium,proventriculus intermediate layer primordium,embryonic proventriculus,embryonic/larval motor neuron,tendon cell,synapse & neuromuscular junctionMK1),RP1 motor neuron,tendon cell & actin filamenthow-24B, sr-md710,tendon cell & microtubulehow-24B, sr-md710" DRSC05459 IE -0.036086644 -3.390270537 -0.954132705 -4.143168369 -1.290758851 -1.384957247 FBgn0003499 sr stripe http://flybase.org/reports/FBgn0003499 "FBgn0010828, FBgn0026215" protein_coding_gene nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR013087 "ectoderm development ; GO:0007398 | inferred from mutant phenotype regulation of glucose metabolic process ; GO:0010906 | inferred from mutant phenotype determination of muscle attachment site ; GO:0016204 | traceable author statement phagocytosis ; GO:0006909 | inferred from mutant phenotype epithelial cell migration, open tracheal system ; GO:0007427 | inferred from mutant phenotype inferred from genetic interaction with bnl pigment metabolic process ; GO:0042440 | traceable author statement muscle organ development ; GO:0007517 | inferred from mutant phenotype central nervous system development ; GO:0007417 | inferred from mutant phenotype somatic muscle development ; GO:0007525 | inferred from mutant phenotype germ-band shortening ; GO:0007390 | inferred from mutant phenotype" - "Sr, l(3)06948, l(3)06948b, l(3)03999, CG7847, sr, SrB, stripe" "IPR013087:Zinc finger C2H2-type, IPR013083:Zinc finger, RING/FYVE/PHD-type, IPR011990:Tetratricopeptide-like helical domain, IPR015943:WD40/YVTN repeat-like-containing domain" CG7847 27-Aug-18 DroID_v2018_08 "Drer\egr2b, Drer\egr4, Drer\osr1, Drer\egr2a, Drer\si:ch211-117k10.3, Drer\osr2, Drer\egr1, Drer\klf15, Drer\klf11a, Drer\sp2, Drer\egr3" "Scer\MIG1, Scer\MSN2, Scer\MIG3, Scer\MSN4, Scer\MIG2, Scer\FZF1" "Cele\odd-1, Cele\odd-2, Cele\egrh-3, Cele\egrh-1" "Xtro\sp2, Xtro\osr2, Xtro\klf15, Xtro\klf11, Xtro\osr1, Xtro\egr2, Xtro\egr3, Xtro\egr1" "Mmus\Sp2, Mmus\Osr1, Mmus\Klf11, Mmus\Egr4, Mmus\Egr1, Mmus\Osr2, Mmus\Egr2, Mmus\Egr3, Mmus\Klf15" "Hsap\SP2, Hsap\EGR4, Hsap\OSR1, Hsap\KLF11, Hsap\KLF15, Hsap\EGR1, Hsap\EGR3, Hsap\EGR2, Hsap\OSR2" " embryonic stage , embryonic stage | stage >=14 , embryonic stage && pupal stage " " muscle attachment site

, epidermis | restricted

" embryonic stage " epidermis | restricted

, muscle attachment site

" "lethal,recessive,viable,visible,flightless,lethal - all die before end of embryonic stage,some die during embryonic stage,cell shape defective,partially lethal - majority die,some die during pupal stage,eye color defective" "thorax,skeletal muscle of abdomen,adult muscle system,dorsal medial muscle,macrochaeta,somatic mesoderm,embryonic/larval dorsal branch,embryonic/larval dorsal trunk,embryonic/larval ganglionic branch,embryonic/larval muscle system,embryonic/larval visceral branch,lch5 cap attachment cell,lch5 ligament attachment cell,muscle fiber,muscle attachment site,embryonic/larval somatic muscle,embryonic/larval tracheal system,adult thorax,mesothoracic tergum & microchaetasr-md710,mesothoracic tergum & chaeta-C253,ventral,lateral transverse muscle | embryonic stage,abdominal 5 ventral longitudinal muscle | embryonic stage,abdominal 6 ventral longitudinal muscle | embryonic stage,abdominal 7 ventral longitudinal muscle | embryonic stage,abdominal 5 lateral transverse muscle | embryonic stage,abdominal 6 lateral transverse muscle | embryonic stage,abdominal 7 lateral transverse muscle | embryonic stage,embryonic somatic muscle,lateral,somatic muscle | embryonic stage,supernumerary,germ band,ectoderm,mesothoracic tergum" FBgn0029891 Pink1 PTEN-induced putative kinase 1 http://flybase.org/reports/FBgn0029891 protein_coding_gene ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR000719 protein serine/threonine kinase activity ; GO:0004674 | inferred from direct assay protein binding ; GO:0005515 | inferred from physical interaction with rho-7 protein binding ; GO:0005515 | inferred from physical interaction with Pgam5 protein kinase activity ; GO:0004672 | inferred from direct assay "mitochondrial fission ; GO:0000266 | inferred from genetic interaction with Drp1 inferred from genetic interaction with Marf inferred from genetic interaction with Opa1 mitochondrion organization ; GO:0007005 | inferred from mutant phenotype inferred from genetic interaction with Buffy mitochondrion transport along microtubule ; GO:0047497 | inferred from mutant phenotype mitochondrion organization ; GO:0007005 | inferred from mutant phenotype negative regulation of programmed cell death ; GO:0043069 | inferred from mutant phenotype establishment of mitochondrion localization ; GO:0051654 | inferred from mutant phenotype negative regulation of mitochondrial fusion ; GO:0010637 | inferred from mutant phenotype regulation of mitochondrial electron transport, NADH to ubiquinone ; GO:1902956 | inferred from genetic interaction with FLYBASE:no biological data available-42; FB:FBgn0019957 positive regulation of compound eye pigmentation ; GO:0048078 | inferred from mutant phenotype negative regulation of neuron apoptotic process ; GO:0043524 | inferred from direct assay protein phosphorylation ; GO:0006468 | inferred from direct assay sperm mitochondrion organization ; GO:0030382 | inferred from mutant phenotype ectopic germ cell programmed cell death ; GO:0035234 | inferred from mutant phenotype regulation of mitochondrion organization ; GO:0010821 | inferred from mutant phenotype mitophagy ; GO:0000422 | inferred from mutant phenotype mitochondrial fission ; GO:0000266 | inferred from genetic interaction with Drp1 inferred from genetic interaction with Opa1 mitochondrion organization ; GO:0007005 | inferred from direct assay positive regulation of mitochondrial fission ; GO:0090141 | inferred from mutant phenotype compound eye development ; GO:0048749 | inferred from mutant phenotype response to oxidative stress ; GO:0006979 | inferred from mutant phenotype intracellular distribution of mitochondria ; GO:0048312 | inferred from mutant phenotype neuromuscular synaptic transmission ; GO:0007274 | inferred from mutant phenotype protein ubiquitination involved in ubiquitin-dependent protein catabolic process ; GO:0042787 | inferred from mutant phenotype" cytoplasm ; GO:0005737 | inferred from direct assay Nebenkern ; GO:0016006 | inferred from direct assay mitochondrion ; GO:0005739 | inferred from direct assay "dPINK1, CG4523, BEST:GH23468, Pink1, PINK1, pink1, dPink1, PINK, dPINk1, Pink, :Pink1" "IPR000719:Protein kinase domain, IPR008271:Serine/threonine-protein kinase, active site, IPR011009:Protein kinase-like domain" CG4523 27-Aug-18 DroID_v2018_08 Drer\pink1 - Cele\pink-1 - Mmus\Pink1 Hsap\PINK1 "visible,neuroanatomy defective,increased cell size,lethal - all die before end of second instar larval stage,some die during second instar larval stage,viable,fertile,progressive,sterile,chemical sensitive,osmotic stress response defective,male sterile,locomotor behavior defective,short lived,increased cell death,flightless,flight defective,heat stress response defective,smell perception defective,neurophysiology defective,recessive,gravitaxis defective,female sterile,partially" "eye,dopamine neuron & adult brainelav.PLu,ommatidium,dopamine neuron & adult brainDdc.PL,interommatidial bristle,pigment cell,photoreceptor & neuronGMR.PF,spermatid,Nebenkern,mitochondrial derivative,dopaminergic neuron,progressive,indirect flight muscle,mitochondrion,mitochondrial crista,mitochondrial crista & indirect flight muscle,minor mitochondrial derivative,wing,depressor muscle,myofibrilda.G32,mitochondrial cristada.G32,mitochondrionMhc.PW,myofibrilMhc.PW,mitochondrial cristaMhc.PW,mitochondrion & dorso-lateral dopaminergic neuronple.PF,adult thorax,mitochondrion & dopaminergic neuron,mitochondrion & indirect flight muscle,mitochondrial inner membrane & indirect flight muscle,mitochondrion & dorso-lateral dopaminergic neuron,dopaminergic PPL1 neuron,dopaminergic PPM1 neuron,dopaminergic PPM2 neuron,neuron,adult somatic muscle,mitochondrial outer membrane,adult antennal lobe,bouton,flight muscle,embryonic/larval neuromuscular junction,synaptic vesicle,spermatozoon,mitochondrial outer membrane & indirect flight muscle,myofibril & indirect flight muscle,dopamine neuron & adult brain,mitochondrion & dopamine neuron & adult brain,thorax,skeletal muscle of thorax,dorso-lateral dopaminergic neuron,Nebenkern derivative,spermatid cyst,eye | adult stage,ommatidium | adult stage" FBgn0039294 Cad96Cb Cadherin 96Cb http://flybase.org/reports/FBgn0039294 protein_coding_gene "calcium ion binding ; GO:0005509 | inferred from electronic annotation with InterPro:IPR002126, InterPro:IPR015919 calcium ion binding ; GO:0005509 | inferred from sequence model" homophilic cell adhesion via plasma membrane adhesion molecules ; GO:0007156 | inferred from electronic annotation with InterPro:IPR002126 open tracheal system development ; GO:0007424 | inferred from genetic interaction with shg calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules ; GO:0016339 | inferred from sequence or structural similarity cell-cell adhesion mediated by cadherin ; GO:0044331 | inferred from sequence model plasma membrane ; GO:0005886 | inferred from electronic annotation with InterPro:IPR020894 integral component of plasma membrane ; GO:0005887 | inferred from sequence or structural similarity "DCad96Cb, CG10421, CT29262, CG13664, Cad96Cb, cad96Cb, cad96C, cg13664, Cad96C" "IPR002126:Cadherin, IPR015919:Cadherin-like, IPR020894:Cadherin conserved site" CG13664 27-Aug-18 DroID_v2018_08 "Drer\pcdh2g8, Drer\LOC100006797, Drer\pcdh2g1, Drer\cdh6, Drer\pcdh1a6, Drer\cdhr1a" - Cele\cdh-9 "Xtro\pcdha13, Xtro\pcdh10, Xtro\pcdh9, Xtro\pcdh8, Xtro\cdh7, Xtro\cdh5" "Mmus\Pcdhb22, Mmus\Pcdh8, Mmus\Pcdhb14, Mmus\Pcdh7, Mmus\Pcdhb10, Mmus\Pcdhb17, Mmus\Cdh9, Mmus\Pcdh20, Mmus\Pcdhb9, Mmus\Pcdh19, Mmus\Pcdhb21, Mmus\Pcdhb5, Mmus\Pcdhb4, Mmus\Pcdhb11, Mmus\Pcdhb6, Mmus\Pcdhb3, Mmus\Pcdhb15, Mmus\Pcdhb1, Mmus\Pcdhb2, Mmus\Pcdhb7, Mmus\Gm37013, Mmus\Cdh6, Mmus\Pcdhgc5, Mmus\Pcdh9, Mmus\Cdhr1, Mmus\Pcdh10, Mmus\Pcdhb12, Mmus\Pcdhb8, Mmus\Pcdhb20, Mmus\Pcdhb13, Mmus\Pcdh12, Mmus\Pcdh17, Mmus\Pcdhb18, Mmus\Pcdhb19, Mmus\Pcdh18, Mmus\Pcdhb16" "Hsap\PCDH20, Hsap\PCDHGA4, Hsap\PCDH8, Hsap\PCDHA12, Hsap\PCDHGA1, Hsap\PCDHA3, Hsap\PCDHA11, Hsap\PCDHGC5, Hsap\PCDHA4, Hsap\PCDHB10, Hsap\PCDH18, Hsap\PCDHGA10, Hsap\PCDH15, Hsap\PCDHGA12, Hsap\PCDHAC2, Hsap\PCDHA10, Hsap\PCDHB15, Hsap\PCDHGA2, Hsap\PCDHA2, Hsap\PCDH10, Hsap\PCDH1, Hsap\PCDHA1, Hsap\PCDH19, Hsap\PCDHB11, Hsap\PCDHA5, Hsap\PCDHGB5, Hsap\PCDHB14, Hsap\PCDHGA11, Hsap\PCDH9, Hsap\PCDHA6, Hsap\CDH24, Hsap\CDH6, Hsap\PCDHB3, Hsap\PCDHA7, Hsap\PCDHB1, Hsap\PCDH17, Hsap\PCDHB12, Hsap\PCDHB4, Hsap\PCDHGB6, Hsap\PCDHB5, Hsap\PCDH7, Hsap\PCDHGC4, Hsap\PCDHB6, Hsap\PCDHB8, Hsap\PCDHGB4, Hsap\PCDHA8, Hsap\PCDHGB7, Hsap\PCDHB2, Hsap\PCDHB7, Hsap\PCDH12, Hsap\PCDHGA3, Hsap\PCDHB16, Hsap\PCDHA13, Hsap\PCDHAC1, Hsap\PCDHGA7, Hsap\PCDHGA6, Hsap\CDHR1, Hsap\PCDHGA9, Hsap\PCDHB13, Hsap\PCDHGA5, Hsap\PCDHA9, Hsap\PCDHGB1, Hsap\PCDHGA8, Hsap\PCDHGB2, Hsap\PCDHGC3, Hsap\PCDHB9, Hsap\PCDHGB3" "viable,partially lethal - majority die,some die during pupal stage" FBgn0026479 Drp1 Dynamin related protein 1 http://flybase.org/reports/FBgn0026479 "FBgn0005566, FBgn0005579, FBgn0031438, FBgn0042649" protein_coding_gene "GTP binding ; GO:0005525 | inferred from electronic annotation with InterPro:IPR000375, InterPro:IPR001401, InterPro:IPR003130, InterPro:IPR030381 microtubule binding ; GO:0008017 | inferred from biological aspect of ancestor with PANTHER:PTN000170013 GTPase activity ; GO:0003924 | inferred from biological aspect of ancestor with PANTHER:PTN000170013" peroxisome fission ; GO:0016559 | inferred from electronic annotation with InterPro:IPR030556 synaptic vesicle budding from presynaptic endocytic zone membrane ; GO:0016185 | non-traceable author statement positive regulation of mitochondrial fission ; GO:0090141 | inferred from mutant phenotype ventral furrow formation ; GO:0007370 | inferred from mutant phenotype membrane fusion ; GO:0061025 | inferred from biological aspect of ancestor with PANTHER:PTN000170085 mitochondrion organization ; GO:0007005 | inferred from mutant phenotype mitochondrial fission ; GO:0000266 | inferred from mutant phenotype sperm mitochondrion organization ; GO:0030382 | inferred from mutant phenotype mitochondrion localization ; GO:0051646 | inferred from mutant phenotype regulation of mitochondrial fission ; GO:0090140 | inferred from mutant phenotype mitotic cytokinesis ; GO:0000281 | inferred from mutant phenotype dynamin family protein polymerization involved in mitochondrial fission ; GO:0003374 | inferred from biological aspect of ancestor with PANTHER:PTN000170085 mitochondrial membrane ; GO:0031966 | inferred from biological aspect of ancestor with PANTHER:PTN000170085 microtubule associated complex ; GO:0005875 | inferred from sequence or structural similarity microtubule associated complex ; GO:0005875 | inferred from direct assay "CG3210, Dnm1/Drp1, l(2)22Fc, l(2)ND2, l(2)ND3, l(2)22Fd, Drp1, Drp-1, drp1, Drp, DRP1, drp-1, frat, DRP" "IPR030381:Dynamin-type guanine nucleotide-binding (G) domain, IPR000375:Dynamin central domain, IPR001401:Dynamin, GTPase domain, IPR003130:Dynamin GTPase effector, IPR019762:Dynamin, GTPase region, conserved site, IPR027417:P-loop containing nucleoside triphosphate hydrolase, IPR020850:GTPase effector domain, IPR030556:Dynamin-1-like protein, IPR022812:Dynamin superfamily" CG3210 27-Aug-18 DroID_v2018_08 "Drer\mxd, Drer\dnm2a, Drer\si:dkeyp-110c12.3, Drer\mxa, Drer\mxc, Drer\mxe, Drer\dnm1b, Drer\dnm3a, Drer\mxg, Drer\dnm1a, Drer\mxf, Drer\dnm1l, Drer\si:dkey-32e23.4, Drer\mxb" "Scer\MGM1, Scer\VPS1, Scer\DNM1" "Cele\drp-1, Cele\dyn-1" "Xtro\dnm2, Xtro\dnm1, Xtro\dnm1l, Xtro\dnm3" "Mmus\Dnm2, Mmus\Dnm3, Mmus\Dnm1, Mmus\Mx1, Mmus\Dnm1l, Mmus\Mx2" "Hsap\DNM2, Hsap\MX1, Hsap\DNM3, Hsap\MX2, Hsap\DNM1, Hsap\DNM1L" "neurophysiology defective,lethal,recessive,viable,visible" "mitochondrion,Nebenkern,mitochondrionMef2.PR,mitochondrion & primary spermatocyte | germ-line clone,Nebenkern | germline clone,mitochondrial derivative | germline clone,lysosome & larval fat body | somatic clone | cell autonomous,autophagic vacuole & larval fat body | somatic clone | cell autonomous,ventral furrow,mitochondrion & larval salivary gland,mitochondrion & bouton,mitochondrion & larval nervous system,mitochondrion & motor neuron,embryonic/larval neuromuscular junction,trichogen cell" DRSC00574 K 1.078866981 -0.158466985 -0.040794711 -0.18690649 1.710953056 0.227550084 FBgn0033550 CG12341 - http://flybase.org/reports/FBgn0033550 protein_coding_gene - - - "BcDNA:SD17342, CG12341" IPR019334:Transmembrane protein 170 CG12341 27-Aug-18 DroID_v2018_08 "Drer\tmem170a, Drer\tmem170b" Scer\YPR153W Cele\F43G9.13 Xtro\tmem170a "Mmus\Tmem170, Mmus\Tmem170b" "Hsap\TMEM170A, Hsap\TMEM170B" viable FBgn0283521 lola longitudinals lacking http://flybase.org/reports/FBgn0283521 protein_coding_gene "protein dimerization activity ; GO:0046983 | inferred from electronic annotation with InterPro:IPR011598 nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR013087 protein binding ; GO:0005515 | inferred from physical interaction with JIL-1 transcription factor activity, sequence-specific DNA binding ; GO:0003700 | inferred from sequence or structural similarity with ttk" "regulation of imaginal disc-derived wing size ; GO:0044719 | inferred from mutant phenotype axon guidance ; GO:0007411 | inferred from mutant phenotype brain morphogenesis ; GO:0048854 | inferred from mutant phenotype regulation of transcription, DNA-templated ; GO:0006355 | inferred from mutant phenotype regulation of transcription from RNA polymerase II promoter ; GO:0006357 | inferred from biological aspect of ancestor with PANTHER:PTN001135004 gonad development ; GO:0008406 | inferred from mutant phenotype larval somatic muscle development ; GO:0007526 | inferred from expression pattern inferred from mutant phenotype axon guidance ; GO:0007411 | inferred from genetic interaction with SoxN positive regulation of transcription, DNA-templated ; GO:0045893 | inferred from sequence or structural similarity with UniProtKB:Q08605 inter-male aggressive behavior ; GO:0002121 | inferred from mutant phenotype antimicrobial humoral response ; GO:0019730 | inferred from mutant phenotype dendrite morphogenesis ; GO:0048813 | inferred from mutant phenotype axon midline choice point recognition ; GO:0016199 | inferred from mutant phenotype inferred from genetic interaction with robo1 inferred from genetic interaction with sli larval lymph gland hemopoiesis ; GO:0035167 | inferred from mutant phenotype locomotion involved in locomotory behavior ; GO:0031987 | inferred from mutant phenotype R3/R4 cell fate commitment ; GO:0007464 | inferred from mutant phenotype startle response ; GO:0001964 | inferred from mutant phenotype nurse cell apoptotic process ; GO:0045476 | inferred from mutant phenotype axonogenesis ; GO:0007409 | inferred from mutant phenotype neurogenesis ; GO:0022008 | inferred from mutant phenotype regulation of glucose metabolic process ; GO:0010906 | inferred from mutant phenotype R7 cell development ; GO:0045467 | inferred from mutant phenotype" nucleoplasm ; GO:0005654 | inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay nucleus ; GO:0005634 | inferred from biological aspect of ancestor with PANTHER:PTN001135004 "lola, CG12052, eyeful, CG18381, CG18379, CG18378, CG30012, BTB-IV, LD03274, l(2)00642, l(2)s3697, bs06a08.y1, NEST:bs06a08, BcDNA:RH31485, sw59, CG30014, CG30013, CG18380, CG18376, BtbIV, BEST:LD03274, BcDNA:LD17006, Lola, fus7, btb" "IPR011598:Myc-type, basic helix-loop-helix (bHLH) domain, IPR000210:BTB/POZ domain, IPR011333:SKP1/BTB/POZ domain, IPR013087:Zinc finger C2H2-type" CG12052 27-Aug-18 DroID_v2018_08 - "Scer\QDR3, Scer\CYK3" "Cele\sdz-28, Cele\btb-13" - Mmus\Zfp219 Hsap\ZBTB20 " embryonic stage | stage 12-17 , embryonic stage | stage >12 , embryonic stage | stage 1-15 , embryonic stage | stage >=10 , embryonic stage | stage 12-14 , embryonic stage | stage 10,11 , embryonic stage | stage 16-17 " " central nervous system

, histoblast

, organism

, mesoderm

, imaginal disc | presumptive

, embryonic peripheral nervous system

, mesectoderm

, embryonic optic lobe primordium

" " embryonic stage , larval stage | third instar , embryonic stage | stage 1-17 , embryonic stage | stage 1-13 , adult stage " " epithelial cell

, embryonic/larval somatic muscle

, central nervous system

, embryonic peripheral nervous system

, tracheocyte

, organism

, organism

" "neuroanatomy defective,courtship behavior defective,male,somatic clone,lethal,recessive,partially lethal - majority die,viable,fertile,behavior defective,visible,wild-type,partially,heat sensitive,some die during pupal stage,body color defective,size defective" "dorsal multidendritic neuron ddaD,dorsal multidendritic neuron ddaE,dorsal multidendritic neuron ddaC,abdominal anterior ventral multidendritic neuron vdaa,ventral multidendritic neuron vdaB,dendrite & adult antennal lobe projection neuron | somatic cloneGH146,axon & adult antennal lobe projection neuron | somatic cloneGH146,adult antennal lobe projection neuron,somatic clone,adult antennal lobe projection neuron DA1 vPN,adult antennal lobe projection neuron VA1v vPN,adult antennal lobe projection neuron adPN,adult antennal lobe projection neuron lPN,adult antennal lobe projection neuron DL1 adPN,lateral horn,dendrite & adult antennal lobe projection neuron | somatic cloneGH146, lolae76,axon & adult antennal lobe projection neuron | somatic cloneGH146, lolae76,longitudinal connective,intersegmental nerve,A1-7 ventral longitudinal muscle 1,A1-7 ventral longitudinal muscle 2,A1-7 ventral longitudinal muscle 3,A1-7 ventral longitudinal muscle 4,abdominal segmental nerve,commissure,VUM interneuron 1,VUM interneuron 2,VUM interneuron 3,abdominal intersegmental nerve,abdominal 1 lateral monoscolopidial chordotonal organ lch1,abdominal 2 lateral monoscolopidial chordotonal organ lch1,abdominal 3 lateral monoscolopidial chordotonal organ lch1,abdominal 4 lateral monoscolopidial chordotonal organ lch1,abdominal 5 lateral monoscolopidial chordotonal organ lch1,abdominal 6 lateral monoscolopidial chordotonal organ lch1,abdominal 7 lateral monoscolopidial chordotonal organ lch1,abdominal 1 lateral pentascolopidial chordotonal organ lch5,abdominal 2 lateral pentascolopidial chordotonal organ lch5,abdominal 3 lateral pentascolopidial chordotonal organ lch5,abdominal 4 lateral pentascolopidial chordotonal organ lch5,abdominal 5 lateral pentascolopidial chordotonal organ lch5,abdominal 6 lateral pentascolopidial chordotonal organ lch5,abdominal 7 lateral pentascolopidial chordotonal organ lch5,VUM neuron,central nervous system,nurse cell,germline clone,egg chamber,axon & adult antennal lobe projection neuron | somatic clone,dendrite & adult antennal lobe projection neuron | somatic clone,macrochaeta,dorsocentral bristle,scutellar bristle,tormogen cell,gonad,gonadal sheath proper primordium,arista,eye,axon,antennal lobe projection neuron adPN,cell autonomous,antennal lobe projection neuron vPN,antennal lobe projection neuron lPN,dendrite & larval antennal lobe projection neuron | somatic clone | penetrance incomplete | expressivity incomplete | cell autonomous,axon & larval antennal lobe projection neuron | somatic clone | penetrance incomplete | expressivity incomplete | cell autonomous,adult mushroom body,dendrite & adult antennal lobe projection neuron | somatic cloneGH146, lola3.8.UAS,dendrite & adult antennal lobe projection neuron | somatic cloneGH146, lola4.7.UAS,axon & adult antennal lobe projection neuron | somatic cloneGH146, lola4.7.UAS,dendrite & adult antennal lobe projection neuron | somatic cloneGH146, lolaL.UAS,axon & adult antennal lobe projection neuron | somatic cloneGH146, lolaL.UAS,ventral longitudinal muscle,presumptive embryonic/larval central nervous system,dorsal appendage,synapsehow-24B,synapsetwi.PG,dendrite & adult antennal lobe projection neuron | somatic clone | heat sensitiveGH146,axon & adult antennal lobe projection neuron | somatic clone | heat sensitiveGH146,heat sensitive,embryonic/larval neuroblast,trichogen cell,mesothoracic tergum,ganglion mother cell,wing,posterior" DRSC27862 IEK 0.725057073 -1.799942145 5.589401193 -1.538656754 1.43490837 1.608543358 FBgn0085106 l(3)S068808 l(3)S068808 http://flybase.org/reports/FBgn0085106 gene - - - l(3)S068808 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0061134 l(3)S001901 lethal (3) S001901 http://flybase.org/reports/FBgn0061134 gene - - - "0019/01, l(3)S001901" - - 27-Aug-18 DroID_v2018_08 - - - - - - "partially lethal - majority die,recessive" FBgn0069234 gl(2L)159-23 gl(2L)159-23 http://flybase.org/reports/FBgn0069234 gene molecular_function ; GO:0003674 | no biological data available morphogenesis of embryonic epithelium ; GO:0016331 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available gl(2L)159-23 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,germline clone,non-rescuable maternal effect,recessive" FBgn0264651 loose-caboose loose caboose http://flybase.org/reports/FBgn0264651 gene - trachea morphogenesis ; GO:0060439 | inferred from mutant phenotype - loose-caboose - - 27-Aug-18 DroID_v2018_08 - - - - - - "embryonic/larval dorsal branch 10,embryonic/larval tracheal system,eye,somatic clone" FBgn0039379 CG5886 - http://flybase.org/reports/FBgn0039379 protein_coding_gene syntaxin binding ; GO:0019905 | inferred from electronic annotation with InterPro:IPR026183 - - CG5886 IPR026183:Taxilin family CG5886 27-Aug-18 DroID_v2018_08 "Drer\txlnba, Drer\slmapb, Drer\txlna, Drer\txlng, Drer\txlnbb" - Cele\T22C1.6 "Xtro\txlna, Xtro\txlng" "Mmus\Txlng, Mmus\Txlnb, Mmus\Txlna" "Hsap\TXLNB, Hsap\PPFIBP1, Hsap\TXLNA, Hsap\TXLNG" viable FBgn0023520 CG3857 - http://flybase.org/reports/FBgn0023520 - protein_coding_gene - "gravitaxis ; GO:0042332 | inferred from mutant phenotype nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ; GO:0000184 | inferred from sequence or structural similarity with UniProtKB:Q9H0W8" intracellular ; GO:0005622 | inferred from sequence or structural similarity with UniProtKB:Q9H0W8 "EG:39E1.3, CG3857" IPR027417:P-loop containing nucleoside triphosphate hydrolase CG3857 27-Aug-18 DroID_v2018_08 Drer\smg9 - Cele\smg-9 Xtro\smg9 Mmus\Smg9 Hsap\SMG9 "gravitaxis defective,viable,lethal" FBgn0051439 Muc96D Mucin 96D http://flybase.org/reports/FBgn0051439 protein_coding_gene chitin binding ; GO:0008061 | inferred from electronic annotation with InterPro:IPR002557 extracellular matrix structural constituent ; GO:0005201 | inferred from sequence model chitin metabolic process ; GO:0006030 | inferred from electronic annotation with InterPro:IPR002557 extracellular region ; GO:0005576 | inferred from electronic annotation with InterPro:IPR002557 extracellular matrix ; GO:0031012 | inferred from sequence model "CG31439, Muc96D" IPR002557:Chitin binding domain CG31439 27-Aug-18 DroID_v2018_08 - Scer\FLO5 - - - - "visible,partially lethal - majority die,some die during pupal stage" "trichogen cell,mesothoracic tergum" FBgn0265758 lncRNA:CR44565 - http://flybase.org/reports/FBgn0265758 non_protein_coding_gene - - - "CR44565, lincRNA.590" - CR44565 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0035954 Doc3 Dorsocross3 http://flybase.org/reports/FBgn0035954 protein_coding_gene "transcription factor activity, sequence-specific DNA binding ; GO:0003700 | inferred from electronic annotation with InterPro:IPR001699, InterPro:IPR002070, InterPro:IPR008967, InterPro:IPR018186" anterior Malpighian tubule development ; GO:0061327 | inferred from mutant phenotype cardiocyte differentiation ; GO:0035051 | inferred from mutant phenotype positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 | inferred from mutant phenotype nucleus ; GO:0005634 | inferred from direct assay "Dm-DOC3, CG5093, Doc3, doc3, Doc" "IPR001699:Transcription factor, T-box, IPR002070:Transcription factor, Brachyury, IPR008967:p53-like transcription factor, DNA-binding, IPR018186:Transcription factor, T-box, conserved site" CG5093 27-Aug-18 DroID_v2018_08 "Drer\tbx6, Drer\tbx3b, Drer\tbx5b, Drer\tbx6l, Drer\tbx5a, Drer\tbx3a, Drer\tbx22, Drer\tbx20, Drer\tbx16, Drer\tbx18, Drer\tbr1b, Drer\mgaa, Drer\eomesa, Drer\tbx21, Drer\tbx2b, Drer\tbr1a, Drer\eomesb, Drer\ta, Drer\tbx4, Drer\tbx2a, Drer\tb, Drer\tbx19, Drer\tbx1" - "Cele\tbx-42, Cele\mls-1, Cele\tbx-11, Cele\tbx-2, Cele\mab-9, Cele\tbx-30" "Xtro\t2, Xtro\eomes, Xtro\tbx1, Xtro\tbx20, Xtro\tbx22, Xtro\tbx4, Xtro\tbx5, Xtro\mga, Xtro\t, Xtro\vegt, Xtro\tbx2, Xtro\tbr1, Xtro\tbx18, Xtro\tbx6, Xtro\tbx3" "Mmus\Tbx18, Mmus\Tbx2, Mmus\Tbx4, Mmus\Tbx22, Mmus\Eomes, Mmus\Tbx3, Mmus\Tbx19, Mmus\Tbr1, Mmus\Mga, Mmus\Tbx1, Mmus\Tbx6, Mmus\Tbx20, Mmus\Tbx15, Mmus\Tbx5, Mmus\T, Mmus\Tbx10, Mmus\Tbx21" "Hsap\TBX10, Hsap\TBX3, Hsap\EOMES, Hsap\MGA, Hsap\TBR1, Hsap\TBX21, Hsap\TBX22, Hsap\TBX4, Hsap\TBX20, Hsap\TBX18, Hsap\T, Hsap\TBX5, Hsap\TBX6, Hsap\TBX2, Hsap\TBX15, Hsap\TBX19, Hsap\TBX1" embryonic stage--pupal stage " embryonic stage , embryonic stage | stage 15-16 , embryonic stage | stage 5-15 , embryonic stage | stage 9-16 , embryonic stage | stage 5-11 " " mesoderm | restricted

, embryonic anterior Malpighian tubule

, abdominal lateral pentascolopidial chordotonal organ lch5

, amnioserosa

, parasegment && ectoderm && mesoderm

, cardioblast | subset

, dorsal pouch

, organism | dorso-lateral

, procephalic neurogenic region

" "viable,chemical resistant" FBgn0063373 snoRNA:snR38:54Ec snoRNA:snR38:54Ec http://flybase.org/reports/FBgn0063373 snoRNA_gene - - - "Snr38snoRNA, CR32901, snoRNA:snR38:54Ec" - CR32901 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0060621 l(3)S088501b lethal (3) S088501b http://flybase.org/reports/FBgn0060621 gene - - - "0885/01, l(3)S088501b" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0038181 CG9297 - http://flybase.org/reports/FBgn0038181 protein_coding_gene - - - "CG9297, Dmel\CG9297" "IPR027417:P-loop containing nucleoside triphosphate hydrolase, IPR022812:Dynamin superfamily, IPR031692:EH domain-containing protein, N-terminal" CG9297 27-Aug-18 DroID_v2018_08 "Drer\ehd1b, Drer\ehd3, Drer\srl, Drer\wu:fb80c09, Drer\ehd1a, Drer\chia.5, Drer\ehd2b, Drer\ovgp1, Drer\chia.1, Drer\ehd2a, Drer\ehd4" Scer\EDE1 "Cele\cht-1, Cele\cht-4, Cele\cht-2" "Xtro\ehd4, Xtro\chia, Xtro\ehd3, Xtro\srl, Xtro\ehd2, Xtro\ehd1, Xtro\chit1, Xtro\LOC548945" "Mmus\Ovgp1, Mmus\Chil6, Mmus\Ehd2, Mmus\Chil3, Mmus\Chil5, Mmus\Chia1, Mmus\Ehd3, Mmus\Ehd1, Mmus\Ehd4, Mmus\Srl, Mmus\Chil1, Mmus\Hmgn5, Mmus\Chit1" "Hsap\CHI3L2, Hsap\HMGN5, Hsap\CHIT1, Hsap\EHD1, Hsap\CHIA, Hsap\OVGP1, Hsap\EHD2, Hsap\EHD4, Hsap\CHI3L1, Hsap\SRL, Hsap\EHD3" "visible,partially lethal - majority die,some die during pupal stage" mesothoracic tergum DRSC16469 E 1.132200079 0.799375909 4.004378938 -1.050881108 -0.225437855 0.043052098 FBgn0263262 spa3 - http://flybase.org/reports/FBgn0263262 gene - gonad development ; GO:0008406 | inferred from mutant phenotype digestive tract mesoderm development ; GO:0007502 | inferred from mutant phenotype - spa3 - - 27-Aug-18 DroID_v2018_08 - - - - - - "gonad,gonadal sheath proper primordium,visceral mesoderm" FBgn0070020 BG01020 BG01020 http://flybase.org/reports/FBgn0070020 gene - - - BG01020 - - 27-Aug-18 DroID_v2018_08 - - - - - - stress response defective FBgn0261581 CG42691 - http://flybase.org/reports/FBgn0261581 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG42691 - CG42691 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0060809 l(3)S054908 lethal (3) S054908 http://flybase.org/reports/FBgn0060809 gene - - - "0549/08, l(3)S054908" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of P-stage,recessive,some die during pharate adult stage" FBgn0051032 CR31032 - http://flybase.org/reports/FBgn0051032 pseudogene_attribute - - - "CG31032, BcDNA:GH15189, CR31032" - CR31032 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0036614 Golgin104 Golgin 104 http://flybase.org/reports/FBgn0036614 protein_coding_gene Rab GTPase binding ; GO:0017137 | inferred from physical interaction with Rab2 signal transducer activity ; GO:0004871 | non-traceable author statement - trans-Golgi network ; GO:0005802 | inferred from direct assay "CG4925, golgin-104, Golgin104" - CG4925 27-Aug-18 DroID_v2018_08 Drer\ccdc186 - "Cele\arrd-16, Cele\cccp-1" Xtro\ccdc186 Mmus\Ccdc186 "Hsap\SRRM5, Hsap\CCDC186" FBgn0011768 Fdh Formaldehyde dehydrogenase http://flybase.org/reports/FBgn0011768 FBgn0002986 protein_coding_gene "zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR002328, InterPro:IPR014183 octanol dehydrogenase activity ; GO:0004552 | inferred from direct assay S-(hydroxymethyl)glutathione dehydrogenase activity ; GO:0051903 | inferred from direct assay alcohol dehydrogenase (NAD) activity ; GO:0004022 | inferred from direct assay S-nitrosoglutathione reductase activity ; GO:0080007 | inferred from mutant phenotype" ethanol oxidation ; GO:0006069 | inferred from electronic annotation with InterPro:IPR014183 regulation of peptidyl-cysteine S-nitrosylation ; GO:2000169 | inferred from mutant phenotype regulation of nitric oxide metabolic process ; GO:0080164 | inferred by curator from GO:0080007 visual learning ; GO:0008542 | inferred from mutant phenotype alcohol metabolic process ; GO:0006066 | inferred by curator from GO:0004022 - "Fdh, ODH, Odh, CG6598, gfd/odh, ADHX, odh, gfd, GSNOR, ADHX_DROME, fdh" "IPR002328:Alcohol dehydrogenase, zinc-type, conserved site, IPR011032:GroES-like, IPR013149:Alcohol dehydrogenase, C-terminal, IPR013154:Alcohol dehydrogenase, N-terminal, IPR014183:Alcohol dehydrogenase class III, IPR016040:NAD(P)-binding domain" CG6598 27-Aug-18 DroID_v2018_08 "Drer\adh8a, Drer\zgc:77938, Drer\zgc:63568, Drer\adh5, Drer\adh8b" "Scer\SFA1, Scer\ADH5" Cele\H24K24.3 "Xtro\adh5, Xtro\adh1a, Xtro\adh1b, Xtro\adh7, Xtro\adh1c, Xtro\adh1" "Mmus\Adh1, Mmus\Adh7, Mmus\Adh6b, Mmus\Adh4, Mmus\Adh6a, Mmus\Adh5" "Hsap\ADH1C, Hsap\ADH1A, Hsap\ADH7, Hsap\ADH4, Hsap\ADH1B, Hsap\ADH5, Hsap\ADH6" larval stage--adult stage "memory defective,heat sensitive,electrophoretic variant,viable,fertile" FBgn0019909 afl autosomal female lethal http://flybase.org/reports/FBgn0019909 - gene - - - afl - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive,heat sensitive" FBgn0030004 CG10958 - http://flybase.org/reports/FBgn0030004 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG10958 "IPR029440:Dynein regulatory complex protein 1, C-terminal" CG10958 27-Aug-18 DroID_v2018_08 Drer\drc1 Scer\VIK1 - Xtro\drc1 Mmus\Drc1 Hsap\DRC1 viable FBgn0060746 l(3)S065312b lethal (3) S065312b http://flybase.org/reports/FBgn0060746 gene - - - "0653/12, l(3)S065312b" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0037831 Cap-H2 Chromosome associated protein H2 http://flybase.org/reports/FBgn0037831 protein_coding_gene protein binding ; GO:0005515 | inferred from physical interaction with MRG15 chromatin binding ; GO:0003682 | inferred from direct assay "chromosome condensation ; GO:0030261 | inferred from electronic annotation with InterPro:IPR031739 chromosome separation ; GO:0051304 | inferred from mutant phenotype inferred from genetic interaction with glu, MRG15 inferred from genetic interaction with Cap-D3 chromosome organization ; GO:0051276 | inferred from mutant phenotype chromatin organization ; GO:0006325 | inferred from mutant phenotype inferred from genetic interaction with MRG15 male meiosis chromosome segregation ; GO:0007060 | inferred from mutant phenotype" condensin complex ; GO:0000796 | inferred from sequence or structural similarity with HGNC:25071 "CG14685, Cap-H2, CAP-H2, CapH2, dCap-H2, cap-H2" "IPR031737:Condensin-2 complex subunit H2, C-terminal, IPR031739:Condensin-2 complex subunit H2" CG14685 27-Aug-18 DroID_v2018_08 Drer\ncaph2 - Cele\kle-2 Xtro\ncaph2 Mmus\Ncaph2 Hsap\NCAPH2 "viable,fertile,meiotic cell cycle defective,male semi-fertile,male sterile" "spermatozoon,polytene chromosome & nurse cell,polytene chromosome & nurse cellExel6159),primary spermatocyte in meiotic prophase I,primary spermatocyte in meiotic anaphase I,polytene chromosome & larval salivary gland43B,polytene chromosome & larval salivary gland | conditional - heat sensitivehs.PB,polytene chromosome & larval salivary glandhs.PB,polytene chromosomehs.PU,embryonic/larval salivary gland | third instar larval stage,nuclear envelopehs.PU" FBgn0260741 CG3281 - http://flybase.org/reports/FBgn0260741 protein_coding_gene zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR012934 nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR013087 positive regulation of JAK-STAT cascade ; GO:0046427 | inferred from mutant phenotype nucleus ; GO:0005634 | inferred from electronic annotation with InterPro:IPR012934 "CG3281, anon-WO0140519.243, 87A7-9/1, anon-87Aa" "IPR012934:Zinc finger, AD-type, IPR013087:Zinc finger C2H2-type" CG3281 27-Aug-18 DroID_v2018_08 "Drer\znf131, Drer\zbtb18, Drer\si:ch211-79k12.2, Drer\zbtb14, Drer\patz1, Drer\si:dkeyp-121d2.7, Drer\bcl6ab, Drer\zbtb7a, Drer\si:ch211-119o8.6, Drer\zbtb24, Drer\zbtb17, Drer\e4f1, Drer\zbtb49" "Scer\AZF1, Scer\ZAP1" "Cele\C04F5.9, Cele\F56D1.1, Cele\Y55F3AM.14, Cele\row-1, Cele\blmp-1" "Xtro\zbtb11, Xtro\zbtb41, Xtro\znf238.2, Xtro\zbtb40, Xtro\zbtb14, Xtro\zbtb26, Xtro\hic1, Xtro\gzf1, Xtro\zbtb7c" "Mmus\Zbtb7a, Mmus\Zbtb42, Mmus\Zbtb7c, Mmus\Zbtb24, Mmus\Zbtb17, Mmus\Zbtb6, Mmus\Mynn, Mmus\Zbtb26, Mmus\Patz1, Mmus\Zfp599, Mmus\Zbtb48, Mmus\Zbtb14, Mmus\Zfp60, Mmus\Bcl6b, Mmus\Vezf1, Mmus\Zfp131, Mmus\Zbtb18, Mmus\Zbtb41, Mmus\Zbtb38, Mmus\Zbtb7b, Mmus\Gzf1" "Hsap\GZF1, Hsap\ZBTB17, Hsap\ZBTB7A, Hsap\PRDM5, Hsap\ZBTB6, Hsap\MYNN, Hsap\ZNF616, Hsap\ZBTB26, Hsap\ZNF131, Hsap\BCL6B, Hsap\ZBTB11, Hsap\ZBTB24, Hsap\ZNF415, Hsap\ZBTB48, Hsap\ZBTB7B, Hsap\ZBTB41, Hsap\PATZ1, Hsap\ZSCAN21, Hsap\ZNF208, Hsap\ZBTB14, Hsap\ZBTB7C, Hsap\ZBTB18" FBgn0030484 GstT4 Glutathione S transferase T4 http://flybase.org/reports/FBgn0030484 protein_coding_gene - biological_process ; GO:0008150 | no biological data available cytoplasm ; GO:0005737 | inferred from sequence or structural similarity with RGD:70952 "GST-theta, CG1681, GstT4, gstt4, GSTT4, DmGSTT4" "IPR004045:Glutathione S-transferase, N-terminal, IPR004046:Glutathione S-transferase, C-terminal, IPR010987:Glutathione S-transferase, C-terminal-like, IPR012336:Thioredoxin-like fold" CG1681 27-Aug-18 DroID_v2018_08 "Drer\gstt1b, Drer\gstt2, Drer\eef1g, Drer\vars, Drer\mars, Drer\gstr, Drer\gstt1a, Drer\eef1e1" "Scer\CAM1, Scer\GTT2, Scer\TEF4, Scer\GTT1, Scer\YGR201C, Scer\URE2" "Cele\gst-37, Cele\gst-32, Cele\gst-34" "Xtro\eef1g, Xtro\gstt1, Xtro\eef1e1" "Mmus\Eef1e1, Mmus\Gstt4, Mmus\Gstt1, Mmus\Gstt2, Mmus\Eef1g, Mmus\Gstt3, Mmus\Vars, Mmus\Mars" "Hsap\GSTT2, Hsap\MARS, Hsap\GSTT2B, Hsap\EEF1E1, Hsap\EEF1G, Hsap\GSTT1, Hsap\VARS" "viable,fertile" FBgn0005130 l(1)X2 lethal (1) X2 http://flybase.org/reports/FBgn0005130 - gene - - - l(1)X2 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of embryonic stage,some die during embryonic stage" "embryonic head,embryonic segment,mitotic cell cycle | gastrula stage" FBgn0065319 l(2)SH1919 lethal (2) SH1919 http://flybase.org/reports/FBgn0065319 gene - - - "l(2)SH1919, l(2)SH2 1919, SH1919" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0024262 acd(2)5M7 auditory courtship defective 5M7 http://flybase.org/reports/FBgn0024262 - gene molecular_function ; GO:0003674 | no biological data available auditory behavior ; GO:0031223 | inferred from mutant phenotype male courtship behavior ; GO:0008049 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available acd(2)5M7 - - 27-Aug-18 DroID_v2018_08 - - - - - - "viable,auditory perception defective" FBgn0275434 asRNA:CR46266 - http://flybase.org/reports/FBgn0275434 non_protein_coding_gene - - - CR46266 - CR46266 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0032341 Reps RALBP1 associated Eps domain containing http://flybase.org/reports/FBgn0032341 protein_coding_gene calcium ion binding ; GO:0005509 | inferred from electronic annotation with InterPro:IPR002048 protein binding ; GO:0005515 | inferred from physical interaction with Rlip - - "REPS, Reps, CG6192" "IPR000261:EH domain, IPR011992:EF-hand domain pair, IPR002048:EF-hand domain" CG6192 27-Aug-18 DroID_v2018_08 "Drer\reps2, Drer\reps1" "Scer\END3, Scer\TAX4, Scer\SLA1, Scer\IRS4, Scer\PAN1, Scer\EDE1" Cele\reps-1 "Xtro\reps2, Xtro\eps15, Xtro\reps1, Xtro\eps15l1" "Mmus\Reps2, Mmus\Eps15l1, Mmus\Reps1" "Hsap\REPS2, Hsap\EPS15, Hsap\REPS1" viable FBgn0051760 CG31760 - http://flybase.org/reports/FBgn0051760 protein_coding_gene G-protein coupled receptor activity ; GO:0004930 | inferred from electronic annotation with InterPro:IPR017978 G-protein coupled receptor signaling pathway ; GO:0007186 | inferred from biological aspect of ancestor with PANTHER:PTN002091395 integral component of membrane ; GO:0016021 | inferred from electronic annotation with InterPro:IPR017978 plasma membrane ; GO:0005886 | inferred from biological aspect of ancestor with PANTHER:PTN002091395 "CG17215, CG17214, BcDNA:RE52162, CG31760" "IPR017978:GPCR family 3, C-terminal" CG31760 27-Aug-18 DroID_v2018_08 "Drer\gpr158b, Drer\si:ch211-156l18.8, Drer\gpr158a" - Cele\F39B2.8 "Xtro\plgrkt, Xtro\gpr158" "Mmus\Gpr179, Mmus\Gpr158" "Hsap\GPR179, Hsap\GPR158" "viable,fertile" DRSC02590 K 0.711210242 -0.529050037 -1.223619393 -0.093090562 -0.324758179 2.060973629 FBgn0034985 CG3328 - http://flybase.org/reports/FBgn0034985 protein_coding_gene "DNA binding ; GO:0003677 | inferred from electronic annotation with InterPro:IPR024061 transcription factor activity, sequence-specific DNA binding ; GO:0003700 | inferred from electronic annotation with InterPro:IPR008967" "regulation of transcription, DNA-templated ; GO:0006355 | inferred from electronic annotation with InterPro:IPR008967" - CG3328 "IPR008967:p53-like transcription factor, DNA-binding, IPR030392:Intramolecular chaperone auto-processing domain, IPR024061:NDT80 DNA-binding domain, IPR011991:Winged helix-turn-helix DNA-binding domain, IPR026932:Myelin gene regulatory factor C-terminal domain 1" CG3328 27-Aug-18 DroID_v2018_08 Drer\myrf - "Cele\myrf-1, Cele\myrf-2" Xtro\myrf "Mmus\Myrf, Mmus\Myrfl" "Hsap\MYRFL, Hsap\MYRF" "viable,fertile" FBgn0044401 Scim26 Sensitized chromosome inheritance modifier 26 http://flybase.org/reports/FBgn0044401 gene - female meiosis chromosome segregation ; GO:0016321 | inferred from mutant phenotype - Scim26 - - 27-Aug-18 DroID_v2018_08 - - - - - - "meiotic cell cycle defective,dominant" FBgn0266200 lncRNA:CR44895 - http://flybase.org/reports/FBgn0266200 non_protein_coding_gene - - - CR44895 - CR44895 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0000406 Cyt-b5-r Cytochrome b5-related http://flybase.org/reports/FBgn0000406 - protein_coding_gene oxidoreductase activity ; GO:0016491 | inferred from electronic annotation with InterPro:IPR012171 heme binding ; GO:0020037 | inferred from electronic annotation with InterPro:IPR018506 "lipid metabolic process ; GO:0006629 | inferred from electronic annotation with InterPro:IPR005804, InterPro:IPR012171" integral component of membrane ; GO:0016021 | inferred from electronic annotation with InterPro:IPR012171 lipid particle ; GO:0005811 | inferred from direct assay mitochondrion ; GO:0005739 | inferred from direct assay "Cyt-b5, Cyt-b, TU-36B, Cytb, TU36B, Cytb5, CG13279, Cyt-b5-r, Cytb5r" "IPR018506:Cytochrome b5, heme-binding site, IPR001199:Cytochrome b5-like heme/steroid binding domain, IPR005804:Fatty acid desaturase domain, IPR012171:Fatty acid desaturase" CG13279 27-Aug-18 DroID_v2018_08 "Drer\dpm3, Drer\fads2, Drer\cyb5a" - "Cele\fbxa-76, Cele\F58B4.2, Cele\C24H12.1, Cele\fat-4, Cele\T27A1.3, Cele\F49E11.8, Cele\fat-3" "Xtro\dpm3, Xtro\fads2" "Mmus\Fads2, Mmus\Dpm3, Mmus\Fads3, Mmus\Fads1, Mmus\4833423E24Rik" "Hsap\DPM3, Hsap\FADS3, Hsap\FADS1, Hsap\FADS2" " embryonic stage | stage 16 , pupal stage | late , larval stage&&adult stage " " larval visceral muscle

, tergosternal muscle

, skeletal muscle of leg

, embryonic/larval somatic muscle

" viable FBgn0003535 stop stopped http://flybase.org/reports/FBgn0003535 - gene - oogenesis ; GO:0048477 | inferred from mutant phenotype - stop - - 27-Aug-18 DroID_v2018_08 - - - - - - female sterile FBgn0034381 List Lithium-inducible SLC6 transporter http://flybase.org/reports/FBgn0034381 protein_coding_gene neurotransmitter:sodium symporter activity ; GO:0005328 | inferred from electronic annotation with InterPro:IPR000175 transporter activity ; GO:0005215 | inferred from biological aspect of ancestor with PANTHER:PTN000177662 cation:amino acid symporter activity ; GO:0005416 | inferred from sequence model neurotransmitter transporter activity ; GO:0005326 | inferred from sequence or structural similarity with DAT transport ; GO:0006810 | inferred from biological aspect of ancestor with PANTHER:PTN000177662 neurotransmitter transport ; GO:0006836 | inferred from sequence or structural similarity with DAT response to lithium ion ; GO:0010226 | inferred from mutant phenotype amino acid transmembrane import ; GO:0044745 | inferred from sequence model integral component of plasma membrane ; GO:0005887 | inferred from biological aspect of ancestor with PANTHER:PTN000177662 integral component of membrane ; GO:0016021 | inferred from sequence model "List, CG15088, DmNAT2" IPR000175:Sodium:neurotransmitter symporter CG15088 27-Aug-18 DroID_v2018_08 "Drer\zgc:158225, Drer\slc6a19a.1, Drer\slc6a11a, Drer\slc6a14, Drer\si:ch211-132b12.6, Drer\slc6a15, Drer\slc6a16a, Drer\slc6a19b, Drer\si:ch211-132b12.2, Drer\slc6a4a, Drer\slc6a2, Drer\slc6a8, Drer\si:ch211-132b12.1, Drer\zgc:174946, Drer\slc6a5, Drer\slc6a6a, Drer\si:ch211-132b12.3, Drer\slc6a18, Drer\slc6a13l, Drer\slc6a17, Drer\slc6a13, Drer\slc6a1l, Drer\slc6a6b, Drer\slc6a1a, Drer\slc6a13, Drer\slc6a4b, Drer\slc6a9, Drer\slc6a1b, Drer\slc6a16b, Drer\si:ch211-117c9.5" - "Cele\snf-9, Cele\mod-5, Cele\snf-5, Cele\snf-3, Cele\dat-1, Cele\snf-7, Cele\snf-12, Cele\snf-11, Cele\snf-6, Cele\snf-2" "Xtro\slc6a13, Xtro\slc6a8, Xtro\slc6a7, Xtro\slc6a17, Xtro\slc6a9, Xtro\slc6a19, Xtro\slc6a6, Xtro\slc6a16, Xtro\slc6a3, Xtro\slc6a15, Xtro\slc6a1, Xtro\slc6a2, Xtro\LOC100127682, Xtro\slc6a4, Xtro\slc6a14.2, Xtro\slc6a12, Xtro\slc6a5" "Mmus\Slc6a18, Mmus\Slc6a5, Mmus\Slc6a13, Mmus\Slc6a20a, Mmus\Slc6a17, Mmus\Slc6a7, Mmus\Slc6a1, Mmus\Slc6a11, Mmus\Slc6a19, Mmus\Slc6a20b, Mmus\Slc6a15, Mmus\Slc6a4, Mmus\Slc6a3, Mmus\Slc6a9, Mmus\Slc6a14, Mmus\Slc6a8, Mmus\Slc6a6, Mmus\Slc6a2, Mmus\Slc6a12" "Hsap\SLC6A17, Hsap\SLC6A18, Hsap\SLC6A20, Hsap\SLC6A19, Hsap\SLC6A2, Hsap\SLC6A7, Hsap\SLC6A14, Hsap\SLC6A13, Hsap\SLC6A9, Hsap\SLC6A11, Hsap\SLC6A3, Hsap\SLC6A15, Hsap\SLC6A5, Hsap\SLC6A4, Hsap\SLC6A12, Hsap\SLC6A8, Hsap\SLC6A1, Hsap\SLC6A6" "chemical sensitive,partially lethal - majority die,some die during pupal stage" FBgn0052826 tRNA:Pro-CGG-1-1 transfer RNA:Proline-CGG 1-1 http://flybase.org/reports/FBgn0052826 tRNA_gene CCG codon-amino acid adaptor activity ; GO:0033424 | inferred from sequence model translation ; GO:0006412 | inferred by curator from GO:0033424 cytosol ; GO:0005829 | inferred by curator from GO:0033424 "AE002611.trna1-ProCGG, tRNA:P:CGG:AE002611, CR32826, chrX.trna15-ProCGG, tRNA-Pro-CGG-1-1, tRNA:Pro-CGG-1-1, tRNA:CR32826, CCG" - CR32826 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0030605 ND-B18 NADH dehydrogenase (ubiquinone) B18 subunit http://flybase.org/reports/FBgn0030605 protein_coding_gene NADH dehydrogenase (ubiquinone) activity ; GO:0008137 | inferred from electronic annotation with InterPro:IPR008698 NADH dehydrogenase activity ; GO:0003954 | inferred from sequence or structural similarity with UniProtKB:P17568 "mitochondrial electron transport, NADH to ubiquinone ; GO:0006120 | inferred from sequence or structural similarity with UniProtKB:P17568" mitochondrial respiratory chain complex I ; GO:0005747 | inferred from sequence or structural similarity with UniProtKB:P17568 "NB8M, ND-B18, CG5548" "IPR008698:NADH:ubiquinone oxidoreductase, B18 subunit" CG5548 27-Aug-18 DroID_v2018_08 Drer\ndufb7 - Cele\D2030.4 Xtro\ndufb7 Mmus\Ndufb7 Hsap\NDUFB7 "visible,lethal - all die before end of pupal stage,some die during pupal stage" trichogen cell FBgn0267899 CR46187 - http://flybase.org/reports/FBgn0267899 pseudogene_attribute - - - "CR46187, CG12717-related" - CR46187 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0037255 Fip1 Factor interacting with poly(A) polymerase 1 http://flybase.org/reports/FBgn0037255 protein_coding_gene myosin binding ; GO:0017022 | inferred from physical interaction with Myo10A RNA binding ; GO:0003723 | contributes_to inferred from biological aspect of ancestor with PANTHER:PTN000336935 pre-mRNA cleavage required for polyadenylation ; GO:0098789 | inferred from biological aspect of ancestor with PANTHER:PTN000336935 positive regulation of Ras protein signal transduction ; GO:0046579 | inferred from genetic interaction with Ras85D mRNA 3'-end processing by stem-loop binding and cleavage ; GO:0006398 | inferred from mutant phenotype mRNA polyadenylation ; GO:0006378 | inferred from biological aspect of ancestor with PANTHER:PTN000336935 positive regulation of ERK1 and ERK2 cascade ; GO:0070374 | inferred from genetic interaction with Ras85D nucleus ; GO:0005634 | inferred from direct assay mRNA cleavage and polyadenylation specificity factor complex ; GO:0005847 | inferred from biological aspect of ancestor with PANTHER:PTN000336935 "clone 1.35, anon-EST:Liang-1.35, Fip1, CG1078, dFip1, FIP1" "IPR002713:FF domain, IPR007854:Pre-mRNA polyadenylation factor Fip1" CG1078 27-Aug-18 DroID_v2018_08 "Drer\fip1l1a, Drer\fip1l1b" Scer\FIP1 Cele\fipp-1 Xtro\fip1l1 Mmus\Fip1l1 Hsap\FIP1L1 "lethal,viable" embryonic/larval brain DRSC12147 K 0.024469664 0.893397531 -0.60381522 -0.264861956 -2.183820967 -0.282578402 FBgn0036311 CG17666 - http://flybase.org/reports/FBgn0036311 protein_coding_gene - - - "bs31g10.y1, CG17666" - CG17666 27-Aug-18 DroID_v2018_08 - - "Cele\C04G6.7, Cele\C27A2.5, Cele\F29D10.2, Cele\T01B7.8, Cele\C04G6.10" - - - viable FBgn0003078 Ppb Photophobe http://flybase.org/reports/FBgn0003078 - gene - - - "Phb, Ppb" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0265994 lncRNA:CR44769 - http://flybase.org/reports/FBgn0265994 non_protein_coding_gene - - - "CR44769, lincRNA.187" - CR44769 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0261611 CG42700 - http://flybase.org/reports/FBgn0261611 protein_coding_gene - - - "CG42700, CG13165, CG34233, ORE-16" IPR015943:WD40/YVTN repeat-like-containing domain CG42700 27-Aug-18 DroID_v2018_08 - - "Cele\H10D18.5, Cele\C01C4.2" - - - FBgn0061162 l(1)6C-166 lethal (1) 6C-166 http://flybase.org/reports/FBgn0061162 gene - - - "6C-166, l(1)6C-166" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0262811 CG43182 - http://flybase.org/reports/FBgn0262811 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG43182 - CG43182 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0003584 su(t) suppressor of tan http://flybase.org/reports/FBgn0003584 - gene - - - su(t) - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0260274 GSd486 - http://flybase.org/reports/FBgn0260274 gene - - - GSd486 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,neuroanatomy defective" "ventral nerve cord,intersegmental nerve,segmental nerve" FBgn0038131 CG15888 - http://flybase.org/reports/FBgn0038131 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG15888 - CG15888 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0261723 Dbx Dbx http://flybase.org/reports/FBgn0261723 protein_coding_gene sequence-specific DNA binding ; GO:0043565 | inferred from electronic annotation with InterPro:IPR017970 "regulation of transcription, DNA-templated ; GO:0006355 | inferred from electronic annotation with InterPro:IPR017970 axon guidance ; GO:0007411 | inferred from mutant phenotype neuron fate commitment ; GO:0048663 | inferred from mutant phenotype" - "Dbx, CG12361, dbx, dDbx, CG42234, CG13925" "IPR017970:Homeobox, conserved site, IPR009057:Homeobox domain-like, IPR001356:Homeobox domain, IPR000047:Helix-turn-helix motif" CG42234 27-Aug-18 DroID_v2018_08 "Drer\dbx1b, Drer\lbx2, Drer\barx2, Drer\tlx2, Drer\lbx1a, Drer\barhl2, Drer\nkx1.2lb, Drer\vox, Drer\tlx1, Drer\dbx2, Drer\ved, Drer\dbx1a, Drer\hlx1, Drer\LOC100008066, Drer\tlx3b, Drer\barx1, Drer\barhl1b, Drer\si:dkey-43p13.5, Drer\nkx6.1, Drer\pnx, Drer\lbx1b" - "Cele\ceh-51, Cele\egl-5" "Xtro\nkx1-1, Xtro\nkx6-3, Xtro\nkx6-2, Xtro\barhl2, Xtro\tlx3, Xtro\tlx1, Xtro\ventx1.2, Xtro\nkx1-2, Xtro\barhl1, Xtro\dbx1, Xtro\barx1, Xtro\tlx2, Xtro\hlx" "Mmus\Lbx2, Mmus\Barhl2, Mmus\Nkx6-2, Mmus\Tlx1, Mmus\Dbx2, Mmus\Nkx1-2, Mmus\Tlx2, Mmus\Barx1, Mmus\Sebox, Mmus\Barx2, Mmus\Nkx1-1, Mmus\Hlx, Mmus\Barhl1, Mmus\Tlx3, Mmus\Nkx6-3, Mmus\Dbx1, Mmus\Lbx1" "Hsap\BARHL2, Hsap\HLX, Hsap\BARX1, Hsap\LEUTX, Hsap\NKX1-1, Hsap\TLX2, Hsap\LBX2, Hsap\TLX1, Hsap\DBX2, Hsap\TLX3, Hsap\NKX6-3, Hsap\DBX1, Hsap\LBX1, Hsap\BARHL1, Hsap\BARX2" DRSC08271 K -0.30386415 0.964323143 -0.33257532 0.319406664 2.870977665 0.982165077 FBgn0262073 JC11 - http://flybase.org/reports/FBgn0262073 gene - response to anesthetic ; GO:0072347 | inferred from mutant phenotype - JC11 - - 27-Aug-18 DroID_v2018_08 - - - - - - "chemical sensitive,recessive" FBgn0003289 Rst(3)amd alpha methyl dopa-resistant on 3 http://flybase.org/reports/FBgn0003289 FBgn0004948 gene - - - "Amdr, Rst(3)amd" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive,chemical resistant,dominant" FBgn0067044 U14 U14 http://flybase.org/reports/FBgn0067044 gene - - - U14 - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,eye color defective,lethal" "chaeta,pigment cell" FBgn0032860 CG15130 - http://flybase.org/reports/FBgn0032860 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "38C.48, CG15130" IPR032006:Transmembrane inner ear expressed protein CG15130 27-Aug-18 DroID_v2018_08 Drer\tmie - Cele\Y39A1C.1 - Mmus\Tmie Hsap\TMIE viable FBgn0266784 lncRNA:CR45249 - http://flybase.org/reports/FBgn0266784 non_protein_coding_gene - - - CR45249 - CR45249 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0001420 l(1)6Dd lethal (1) 6Dd http://flybase.org/reports/FBgn0001420 - gene - - - l(1)6Dd - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0003074 Pgi Phosphoglucose isomerase http://flybase.org/reports/FBgn0003074 - protein_coding_gene glucose-6-phosphate isomerase activity ; GO:0004347 | inferred from mutant phenotype "gluconeogenesis ; GO:0006094 | inferred from electronic annotation with InterPro:IPR001672, InterPro:IPR018189 glycolytic process ; GO:0006096 | inferred from electronic annotation with InterPro:IPR001672, InterPro:IPR018189, InterPro:IPR023096" lipid particle ; GO:0005811 | inferred from direct assay "CG8251, GPI, pgi, Gpi, PGI, Pgi, gpi" "IPR018189:Phosphoglucose isomerase, conserved site, IPR001672:Phosphoglucose isomerase (PGI), IPR023096:Phosphoglucose isomerase, C-terminal" CG8251 27-Aug-18 DroID_v2018_08 "Drer\gpib, Drer\gpia" Scer\PGI1 Cele\gpi-1 Xtro\gpi Mmus\Gpi1 Hsap\GPI "electrophoretic variant,slow,viable,fertile,lethal,recessive" FBgn0003482 spn-D spindle D http://flybase.org/reports/FBgn0003482 "FBgn0047153, FBgn0051069" protein_coding_gene ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR020588 DNA-dependent ATPase activity ; GO:0008094 | inferred from biological aspect of ancestor with PANTHER:PTN001415033 single-stranded DNA binding ; GO:0003697 | inferred from biological aspect of ancestor with PANTHER:PTN001415033 endodeoxyribonuclease activity ; GO:0004520 | contributes_to inferred from biological aspect of ancestor with PANTHER:PTN001415033 four-way junction DNA binding ; GO:0000400 | inferred from biological aspect of ancestor with PANTHER:PTN001415033 double-stranded DNA binding ; GO:0003690 | inferred from biological aspect of ancestor with PANTHER:PTN001415033 recombinase activity ; GO:0000150 | inferred from biological aspect of ancestor with PANTHER:PTN001415033 oocyte fate determination ; GO:0030716 | inferred from mutant phenotype strand invasion ; GO:0042148 | inferred from biological aspect of ancestor with PANTHER:PTN001415033 intracellular mRNA localization ; GO:0008298 | traceable author statement response to ionizing radiation ; GO:0010212 | inferred from biological aspect of ancestor with PANTHER:PTN001415033 reciprocal meiotic recombination ; GO:0007131 | inferred from mutant phenotype polarity specification of dorsal/ventral axis ; GO:0009951 | inferred from mutant phenotype microtubule organizing center organization ; GO:0031023 | inferred from mutant phenotype mitotic recombination ; GO:0006312 | inferred from biological aspect of ancestor with PANTHER:PTN001415033 oogenesis ; GO:0048477 | traceable author statement oogenesis ; GO:0048477 | inferred from genetic interaction with fs(1)K10 meiotic DNA recombinase assembly ; GO:0000707 | inferred from biological aspect of ancestor with PANTHER:PTN001118198 oocyte localization involved in germarium-derived egg chamber formation ; GO:0030720 | inferred from mutant phenotype intracellular mRNA localization ; GO:0008298 | inferred from mutant phenotype germarium-derived oocyte fate determination ; GO:0007294 | inferred from genetic interaction with mus301 dorsal appendage formation ; GO:0046843 | inferred from mutant phenotype polarity specification of anterior/posterior axis ; GO:0009949 | inferred from mutant phenotype reciprocal meiotic recombination ; GO:0007131 | traceable author statement karyosome formation ; GO:0030717 | inferred from mutant phenotype Rad51B-Rad51C-Rad51D-XRCC2 complex ; GO:0033063 | inferred from biological aspect of ancestor with PANTHER:PTN001118198 replication fork ; GO:0005657 | inferred from biological aspect of ancestor with PANTHER:PTN001118198 "spn-D, Spn-D, spnD, spndD, CG31069, BcDNA:RE19845, rad51C" "IPR013632:DNA recombination and repair protein Rad51-like, C-terminal, IPR027417:P-loop containing nucleoside triphosphate hydrolase, IPR020588:DNA recombination and repair protein RecA-like, ATP-binding domain" CG31069 27-Aug-18 DroID_v2018_08 "Drer\rad51c, Drer\xrcc3" "Scer\DMC1, Scer\RAD51, Scer\RAD55, Scer\RAD57" Cele\rad-51 "Xtro\rad51c, Xtro\xrcc3" "Mmus\Rad51b, Mmus\Xrcc3, Mmus\Rad51c" "Hsap\RAD51C, Hsap\RAD51B, Hsap\XRCC3" adult stage | female ovary

"viable,fertile,lethal" "chorion | maternal effect,karyosome,egg,dorsal,dorsal appendage,oocyte,nurse cell,synaptonemal complex,germline cyst,microtubule organizing center & oocyte,presumptive oocyte" FBgn0025393 CG14795 - http://flybase.org/reports/FBgn0025393 - protein_coding_gene - - - "EG:196F3.3, CG14795" - CG14795 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of pupal stage,some die during pupal stage" FBgn0005232 l(3)R26 lethal of Roberts 26 http://flybase.org/reports/FBgn0005232 - gene - - - "l(3)26, l(3)R26" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,polyphasic,recessive" FBgn0037280 CG1126 - http://flybase.org/reports/FBgn0037280 protein_coding_gene phosphatidylinositol-3-phosphate binding ; GO:0032266 | inferred from sequence or structural similarity with HGNC:970 phosphatidylinositol-3-phosphate binding ; GO:0032266 | inferred from biological aspect of ancestor with PANTHER:PTN000482504 cilium assembly ; GO:0060271 | inferred from sequence or structural similarity with HGNC:970 intracellular transport ; GO:0046907 | inferred from biological aspect of ancestor with PANTHER:PTN000482504 cilium assembly ; GO:0060271 | inferred from sequence model inferred from expression pattern BBSome ; GO:0034464 | inferred from biological aspect of ancestor with PANTHER:PTN000482504 BBSome ; GO:0034464 | inferred from sequence or structural similarity with HGNC:970 ciliary basal body ; GO:0036064 | inferred from biological aspect of ancestor with PANTHER:PTN000482504 "CG1126, BBS5" "IPR006606:Bardet-Biedl syndrome 5 protein, IPR014003:DM16 repeat, IPR030804:Bardet-Biedl syndrome 5 protein/sex-determination protein fem-3, IPR011993:PH domain-like" CG1126 27-Aug-18 DroID_v2018_08 "Drer\klhl41a, Drer\klhl40a, Drer\bbs5, Drer\klhl41b, Drer\klhl40b" - "Cele\bbs-5, Cele\pafo-1" "Xtro\paf1, Xtro\klhl40, Xtro\bbs5, Xtro\klhl41" "Mmus\Bbs5, Mmus\Klhl41, Mmus\Paf1, Mmus\Klhl40" "Hsap\KLHL40, Hsap\PAF1, Hsap\KLHL41, Hsap\BBS5" viable DRSC12168 E 0.649027914 0.578822865 -1.670328423 0.470314141 0.340752514 0.129257066 FBgn0029184 E(Khc)ek2 E(Khc)ek2 http://flybase.org/reports/FBgn0029184 gene - - - E(Khc)ek2 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0030443 CG12715 - http://flybase.org/reports/FBgn0030443 protein_coding_gene - - - CG12715 IPR008166:Glycosyltransferase family 92 CG12715 27-Aug-18 DroID_v2018_08 "Drer\si:zfos-464b6.2, Drer\si:dkey-56i24.1, Drer\si:ch73-211l2.1, Drer\zgc:194839" - "Cele\ZK1025.4, Cele\C14C6.6, Cele\galt-1, Cele\C49A1.5, Cele\C18G1.7, Cele\Y47D3B.4, Cele\F36F12.3, Cele\C14C6.8, Cele\F13G3.3, Cele\ZK488.6, Cele\C31B8.7, Cele\F49C12.5, Cele\K06H6.4, Cele\C01G5.9, Cele\F28H7.7, Cele\ZK488.5, Cele\F46F5.7" "Xtro\LOC100492375, Xtro\LOC100145503, Xtro\LOC100495879" - - viable FBgn0032848 nesd nessun dorma http://flybase.org/reports/FBgn0032848 protein_coding_gene carbohydrate binding ; GO:0030246 | inferred from physical interaction with CHEBI:59521 female germline ring canal stabilization ; GO:0008335 | inferred from mutant phenotype male meiosis cytokinesis ; GO:0007112 | inferred from mutant phenotype midbody ; GO:0030496 | inferred from direct assay male germline ring canal ; GO:0035323 | inferred from direct assay fusome ; GO:0045169 | inferred from direct assay intercellular bridge ; GO:0045171 | inferred from direct assay female germline ring canal ; GO:0035324 | inferred from direct assay "38B.16, CG10722, nesd" "IPR011050:Pectin lyase fold/virulence factor, IPR012334:Pectin lyase fold" CG10722 27-Aug-18 DroID_v2018_08 Drer\shcbp1 - - Xtro\shcbp1 "Mmus\Shcbp1l, Mmus\Shcbp1" "Hsap\SHCBP1, Hsap\SHCBP1L" "viable,fertile,male semi-sterile,meiotic cell cycle defective,partially lethal - majority die" "onion stage spermatid,Nebenkern,contractile ring,cleavage furrow,spermatocyte ring canal,nurse cell ring canal,nurse cell" FBgn0065114 mfs(1)6E male-female-sterile in region 6E http://flybase.org/reports/FBgn0065114 gene - "regulation of female receptivity, post-mating ; GO:0046008 | inferred from mutant phenotype sperm storage ; GO:0046693 | inferred from mutant phenotype" - mfs(1)6E - - 27-Aug-18 DroID_v2018_08 - - - - - - "male sterile,recessive,female sterile" "male accessory gland,male accessory gland main cell" FBgn0035028 Start1 Start1 http://flybase.org/reports/FBgn0035028 protein_coding_gene cholesterol binding ; GO:0015485 | inferred from biological aspect of ancestor with PANTHER:PTN000253260 - - "CG3522, Start, Start1, start1, StART1" "IPR000799:Steroidogenic acute regulatory protein-like, IPR002913:START domain, IPR023393:START-like domain, IPR019498:MENTAL domain" CG3522 27-Aug-18 DroID_v2018_08 "Drer\star, Drer\LOC100331467, Drer\stard3, Drer\stard3nl, Drer\stard5" - "Cele\strl-1, Cele\tag-340" "Xtro\star, Xtro\stard3, Xtro\stard3nl" "Mmus\Stard5, Mmus\Stard3, Mmus\Stard3nl, Mmus\Star, Mmus\Stard6, Mmus\Acot12" "Hsap\STARD6, Hsap\STARD5, Hsap\STARD3, Hsap\STARD3NL, Hsap\STAR" viable FBgn0265918 lncRNA:CR44707 - http://flybase.org/reports/FBgn0265918 non_protein_coding_gene - - - "lincRNA.1015, CR44707" - CR44707 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0046678 anon-38C.15 anon-38C.15 http://flybase.org/reports/FBgn0046678 gene - - - "38C.15, anon-38C.15" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0263656 CG43647 - http://flybase.org/reports/FBgn0263656 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG43647, mlncRNA42E5-1, lincRNA.258" - CG43647 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0058005 CR40005 - http://flybase.org/reports/FBgn0058005 pseudogene_attribute - - - "CG40005, CR40005" - CR40005 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0028856 CG18063 - http://flybase.org/reports/FBgn0028856 protein_coding_gene myosin light chain binding ; GO:0032027 | inferred from reviewed computational analysis - - "DS07486.5, BG:DS07486.5, CG18063" "IPR027417:P-loop containing nucleoside triphosphate hydrolase, IPR000048:IQ motif, EF-hand binding site" CG18063 27-Aug-18 DroID_v2018_08 Drer\spata17 - - - Mmus\Spata17 Hsap\SPATA17 viable FBgn0040546 CG14705 - http://flybase.org/reports/FBgn0040546 protein_coding_gene - - - CG14705 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0001415 l(1)3Ee lethal (1) 3Ee http://flybase.org/reports/FBgn0001415 - gene - - - "l(1)RC245, l(1)3Ee" - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0067729 l(3)J1 lethal (3) J1 http://flybase.org/reports/FBgn0067729 gene - - - l(3)J1 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0083008 snoRNA:Psi28S-1135e snoRNA:Psi28S-1135e http://flybase.org/reports/FBgn0083008 snoRNA_gene - - - "snoRNA:Psi28S-1135e, Psi28S-1135e, psi28S-1135e, CR34601, chrX:16979721..16979820" - CR34601 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0050058 CG30058 - http://flybase.org/reports/FBgn0050058 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG30058 - CG30058 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0051230 CG31230 - http://flybase.org/reports/FBgn0051230 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG31230 - CG31230 27-Aug-18 DroID_v2018_08 - - - - - - "viable,visible" mesothoracic tergum FBgn0259183 CG42287 - http://flybase.org/reports/FBgn0259183 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG13353, CG42287" - CG42287 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0036330 CG11263 - http://flybase.org/reports/FBgn0036330 protein_coding_gene RNA binding ; GO:0003723 | inferred from sequence or structural similarity with UniProtKB:H9IUR0 3'-5' exonuclease activity ; GO:0008408 | NOT inferred from sequence or structural similarity with UniProtKB:H9IUR0 protein homodimerization activity ; GO:0042803 | inferred from sequence or structural similarity with UniProtKB:H9IUR0 - P granule ; GO:0043186 | inferred from sequence or structural similarity with UniProtKB:H9IUR0 CG11263 IPR012337:Ribonuclease H-like domain CG11263 27-Aug-18 DroID_v2018_08 Drer\exd1 - Cele\egal-1 Xtro\exd1 Mmus\Exd1 Hsap\EXD1 "partially lethal - majority die,some die during pupal stage" FBgn0060534 l(3)S100513 lethal (3) S100513 http://flybase.org/reports/FBgn0060534 gene - - - "1005/13, l(3)S100513" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0017427 anon-68Ea anon-68Ea http://flybase.org/reports/FBgn0017427 - gene - - - "T1, anon-68Ea" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0025157 ms(2)A10 ms(2)A10 http://flybase.org/reports/FBgn0025157 - gene - - - ms(2)A10 - - 27-Aug-18 DroID_v2018_08 - - - - - - "male sterile,recessive" FBgn0262712 ifm(2)RS5 - http://flybase.org/reports/FBgn0262712 gene - flight ; GO:0060361 | inferred from mutant phenotype adult somatic muscle development ; GO:0007527 | inferred from mutant phenotype - ifm(2)RS5 - - 27-Aug-18 DroID_v2018_08 - - - - - - "flightless,recessive" dorsal medial muscle FBgn0050212 tRNA:Arg-CCT-1-2 transfer RNA:Arginine-CCT 1-2 http://flybase.org/reports/FBgn0050212 tRNA_gene AGG codon-amino acid adaptor activity ; GO:0033448 | inferred from sequence model translation ; GO:0006412 | inferred by curator from GO:0033448 cytosol ; GO:0005829 | inferred by curator from GO:0033448 "AE002787.trna2-ArgCCT, tRNA:R:CCT:AE002787-a, CR30133, CR30212, chr2R.trna60-ArgCCT, tRNA-Arg-CCT-1-2, tRNA:Arg-CCT-1-2, tRNA:CR30212, AGG" - CR30212 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0031126 Cyp6v1 Cyp6v1 http://flybase.org/reports/FBgn0031126 protein_coding_gene "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ; GO:0016705 | inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972 heme binding ; GO:0020037 | inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401 iron ion binding ; GO:0005506 | inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401 oxidoreductase activity ; GO:0016491 | inferred from biological aspect of ancestor with PANTHER:PTN001209891" "oxidation-reduction process ; GO:0055114 | inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972" - "6v1, CG1829, Cyp6v1" "IPR001128:Cytochrome P450, IPR002401:Cytochrome P450, E-class, group I, IPR017972:Cytochrome P450, conserved site" CG1829 27-Aug-18 DroID_v2018_08 "Drer\tbxas1, Drer\cyp3c2, Drer\cyp3a65, Drer\cyp3c3, Drer\cyp3c1, Drer\cyp3c4" Scer\ERG11 "Cele\cyp-13A1, Cele\cyp-13A12, Cele\cyp-43A1, Cele\cyp-13A4, Cele\cyp-44A1, Cele\cyp-13A7, Cele\cyp-25A2, Cele\cyp-13A8, Cele\cyp-13A10, Cele\cyp-13A2, Cele\cyp-25A1, Cele\cyp-13B2, Cele\cyp-13A5, Cele\cyp-25A6, Cele\cyp-13A3, Cele\cyp-13A11, Cele\cyp-25A3, Cele\cyp-13A6, Cele\cyp-13B1, Cele\cyp-25A4" "Xtro\tbxas1, Xtro\LOC100494419, Xtro\cyp3a4, Xtro\cyp3a5" "Mmus\Cyp3a59, Mmus\Cyp3a41a, Mmus\Cyp3a41b, Mmus\Tbxas1, Mmus\Cyp3a25, Mmus\Cyp3a44, Mmus\Cyp3a57, Mmus\Cyp3a16, Mmus\Cyp3a13, Mmus\Cyp3a11" "Hsap\CYP3A5, Hsap\CYP3A7, Hsap\TBXAS1, Hsap\CYP3A7-CYP3A51P, Hsap\CYP3A4, Hsap\CYP3A43" "viable,fertile" FBgn0005272 l(3)SG92 lethal (3) SG92 http://flybase.org/reports/FBgn0005272 - gene - - - l(3)SG92 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0000225 Bsb Blunt short bristle http://flybase.org/reports/FBgn0000225 - gene molecular_function ; GO:0003674 | no biological data available antennal morphogenesis ; GO:0048800 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available Bsb - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,dominant,lethal,recessive,viable,fertile" "macrochaeta,arista,arista lateral,actin filament & arista,microtubule & arista" FBgn0015922 cln clown http://flybase.org/reports/FBgn0015922 - gene - compound eye cone cell differentiation ; GO:0042675 | inferred from mutant phenotype compound eye morphogenesis ; GO:0001745 | inferred from mutant phenotype negative regulation of epidermal growth factor receptor signaling pathway ; GO:0042059 | inferred from genetic interaction with aos - cln - - 27-Aug-18 DroID_v2018_08 - - - - - - "viable,eye color defective,recessive,visible,fertile,female fertile,male fertile" "eye,ommatidium,pigment cell,secondary pigment cell,ectopic,tertiary pigment cell,cone cell,eye disc & photoreceptor cell,photoreceptor cell,lens,dorsal compartment" FBgn0029864 CG15894 - http://flybase.org/reports/FBgn0029864 protein_coding_gene - - - CG15894 - CG15894 27-Aug-18 DroID_v2018_08 - - - - - - "viable,fertile" FBgn0040705 ND-B8 NADH dehydrogenase (ubiquinone) B8 subunit http://flybase.org/reports/FBgn0040705 protein_coding_gene NADH dehydrogenase (ubiquinone) activity ; GO:0008137 | inferred from biological aspect of ancestor with PANTHER:PTN000306062 NADH dehydrogenase activity ; GO:0003954 | inferred from sequence or structural similarity with UniProtKB:O43678 "mitochondrial electron transport, NADH to ubiquinone ; GO:0006120 | inferred from sequence or structural similarity with UniProtKB:O43678" mitochondrial respiratory chain complex I ; GO:0005747 | inferred from biological aspect of ancestor with PANTHER:PTN000306062 mitochondrial respiratory chain complex I ; GO:0005747 | inferred from sequence or structural similarity with UniProtKB:O43678 "CG15434, NI8M, ND-B8" "IPR007741:Ribosomal protein/NADH dehydrogenase domain, IPR016464:NADH dehydrogenase [ubiquinone] (complex I), alpha subcomplex, subunit 2, IPR012336:Thioredoxin-like fold" CG15434 27-Aug-18 DroID_v2018_08 Drer\ndufa2 Scer\MRPL51 Cele\Y63D3A.7 "Xtro\ndufa2, Xtro\LOC100495196" Mmus\Ndufa2 Hsap\NDUFA2 "viable,visible,planar polarity defective" mesothoracic tergum FBgn0264698 lncRNA:CR43967 - http://flybase.org/reports/FBgn0264698 non_protein_coding_gene - - - CR43967 - CR43967 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0013910 Dtf-1 Dtf-1 http://flybase.org/reports/FBgn0013910 - gene - - - "DTF-1, Dtf-1" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0025160 l(2)GA339 lethal (2) GA339 http://flybase.org/reports/FBgn0025160 - gene - - - "GA339, l(2)GA339" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" ganglion mother cell GMC4-2a FBgn0262105 lncRNA:CR42858 - http://flybase.org/reports/FBgn0262105 non_protein_coding_gene - spermatogenesis ; GO:0007283 | inferred from mutant phenotype regulation of gene expression ; GO:0010468 | inferred from mutant phenotype - CR42858 - CR42858 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0053483 CG33483 - http://flybase.org/reports/FBgn0053483 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG33483 IPR010512:Protein of unknown function DUF1091 CG33483 27-Aug-18 DroID_v2018_08 - - Cele\K12H4.7 - - - FBgn0260366 GSd234 - http://flybase.org/reports/FBgn0260366 gene - - - GSd234 - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0011659 Mlh1 Mlh1 http://flybase.org/reports/FBgn0011659 - protein_coding_gene "mismatched DNA binding ; GO:0030983 | inferred from electronic annotation with InterPro:IPR002099, InterPro:IPR013507 ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR002099, InterPro:IPR013507 ATPase activity ; GO:0016887 | inferred from biological aspect of ancestor with PANTHER:PTN000008161 single-stranded DNA binding ; GO:0003697 | inferred from biological aspect of ancestor with PANTHER:PTN000008161" mismatch repair ; GO:0006298 | inferred from biological aspect of ancestor with PANTHER:PTN000008161 MutLalpha complex ; GO:0032389 | inferred from biological aspect of ancestor with PANTHER:PTN000008164 synaptonemal complex ; GO:0000795 | inferred from biological aspect of ancestor with PANTHER:PTN000008164 chiasma ; GO:0005712 | inferred from biological aspect of ancestor with PANTHER:PTN000008164 "dmlh1, dmlh-1, CG11482, Mlh1" "IPR002099:DNA mismatch repair protein family, IPR003594:Histidine kinase-like ATPase, C-terminal domain, IPR013507:DNA mismatch repair protein, C-terminal, IPR014721:Ribosomal protein S5 domain 2-type fold, subgroup, IPR014762:DNA mismatch repair, conserved site, IPR020568:Ribosomal protein S5 domain 2-type fold, IPR032189:DNA mismatch repair protein Mlh1, C-terminal" CG11482 27-Aug-18 DroID_v2018_08 Drer\mlh1 Scer\MLH1 Cele\mlh-1 Xtro\mlh1 Mmus\Mlh1 Hsap\MLH1 viable FBgn0063485 Lasp Lasp http://flybase.org/reports/FBgn0063485 protein_coding_gene zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR001781 protein binding ; GO:0005515 | inferred from physical interaction with Actn actin binding ; GO:0003779 | inferred from direct assay regulation of myofibril size ; GO:0014881 | inferred from mutant phenotype muscle thin filament assembly ; GO:0071689 | inferred from mutant phenotype pole cell formation ; GO:0007279 | inferred from mutant phenotype positive regulation of pole plasm oskar mRNA localization ; GO:0045856 | inferred from mutant phenotype sperm individualization ; GO:0007291 | inferred from mutant phenotype sarcomere organization ; GO:0045214 | inferred from mutant phenotype spermatogenesis ; GO:0007283 | inferred from mutant phenotype sperm individualization complex ; GO:0070864 | inferred from direct assay focal adhesion ; GO:0005925 | inferred from direct assay Z disc ; GO:0030018 | inferred from direct assay A band ; GO:0031672 | inferred from direct assay cytosol ; GO:0005829 | inferred from direct assay "CG3849, cDNA B, anon-73Bd, Lasp, lasp" "IPR000900:Nebulin repeat, IPR001452:SH3 domain, IPR001781:Zinc finger, LIM-type" CG3849 27-Aug-18 DroID_v2018_08 "Drer\neb, Drer\nrap, Drer\lasp1, Drer\nebl, Drer\dbnlb" "Scer\ABP1, Scer\BOI1" "Cele\F42H10.3, Cele\dbn-1" "Xtro\nebl, Xtro\neb, Xtro\lasp1" "Mmus\Dbnl, Mmus\Nrap, Mmus\Lasp1, Mmus\Nebl, Mmus\Neb" "Hsap\LASP1, Hsap\NEB, Hsap\NEBL, Hsap\NRAP, Hsap\DBNL" "partially lethal - majority die,hatching behavior defective,decreased cell number,grandchildless,lethal,recessive,lethal - all die before end of pupal stage,some die during pupal stage,visible,viable,male sterile,female fertile,reduced" "pole cell,ectopic,hub cell,trichogen cell,mesothoracic tergum,investment cone,individualization stage spermatid" DRSC10379 EK -0.43576585 0.184164187 -0.940571665 1.503371166 2.30026385 0.235878809 FBgn0001529 l(1)11Ee lethal (1) 11Ee http://flybase.org/reports/FBgn0001529 - gene - - - l(1)11Ee - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0016669 Hrp75 Hrp75 http://flybase.org/reports/FBgn0016669 - gene single-stranded DNA binding ; GO:0003697 | inferred from direct assay biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "hrp75, Hrp75" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0031968 CG7231 - http://flybase.org/reports/FBgn0031968 protein_coding_gene - - - CG7231 IPR019356:Protein of unknown function DUF2181 CG7231 27-Aug-18 DroID_v2018_08 "Drer\fam151a, Drer\fam151b" - Cele\mnr-1 "Xtro\fam151a, Xtro\fam151b" "Mmus\Fam151b, Mmus\Fam151a" "Hsap\FAM151B, Hsap\FAM151A" "lethal,recessive,viable,fertile" FBgn0039616 CG11828 - http://flybase.org/reports/FBgn0039616 protein_coding_gene "procollagen-proline 4-dioxygenase activity ; GO:0004656 | inferred from electronic annotation with InterPro:IPR013547 L-ascorbic acid binding ; GO:0031418 | inferred from electronic annotation with InterPro:IPR006620 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ; GO:0016702 | inferred from electronic annotation with InterPro:IPR013547 iron ion binding ; GO:0005506 | inferred from electronic annotation with InterPro:IPR006620" "oxidation-reduction process ; GO:0055114 | inferred from electronic annotation with InterPro:IPR006620, InterPro:IPR013547 multicellular organism reproduction ; GO:0032504 | inferred from expression pattern" endoplasmic reticulum ; GO:0005783 | inferred from electronic annotation with InterPro:IPR013547 CG11828 "IPR013547:Prolyl 4-hydroxylase alpha-subunit, N-terminal, IPR006620:Prolyl 4-hydroxylase, alpha subunit, IPR011990:Tetratricopeptide-like helical domain" CG11828 27-Aug-18 DroID_v2018_08 "Drer\p4ha1b, Drer\p4ha3, Drer\p4ha1a, Drer\p4ha2, Drer\zgc:152670, Drer\zgc:158254, Drer\p4htm" - "Cele\Y43F8B.19, Cele\phy-3, Cele\phy-4, Cele\C14E2.4, Cele\phy-2" "Xtro\p4ha1, Xtro\p4ha2, Xtro\p4ha3" "Mmus\P4htm, Mmus\P4ha2, Mmus\P4ha3, Mmus\P4ha1" "Hsap\P4HA2, Hsap\P4HTM, Hsap\P4HA3, Hsap\P4HA1" viable FBgn0041184 Socs36E Suppressor of cytokine signaling at 36E http://flybase.org/reports/FBgn0041184 protein_coding_gene protein kinase inhibitor activity ; GO:0004860 | inferred from biological aspect of ancestor with PANTHER:PTN000043893 positive regulation of proteasomal ubiquitin-dependent protein catabolic process ; GO:0032436 | inferred from electronic annotation with InterPro:IPR028420 haltere development ; GO:0007482 | inferred from mutant phenotype border follicle cell migration ; GO:0007298 | inferred from mutant phenotype notum morphogenesis ; GO:0048802 | inferred from mutant phenotype regulation of JAK-STAT cascade ; GO:0046425 | traceable author statement germ-line stem cell population maintenance ; GO:0030718 | inferred from mutant phenotype negative regulation of sevenless signaling pathway ; GO:0045873 | inferred from genetic interaction with sev negative regulation of protein kinase activity ; GO:0006469 | inferred from biological aspect of ancestor with PANTHER:PTN000043893 cytokine-mediated signaling pathway ; GO:0019221 | inferred from biological aspect of ancestor with PANTHER:PTN000043893 long-term memory ; GO:0007616 | inferred from mutant phenotype negative regulation of JAK-STAT cascade ; GO:0046426 | inferred from genetic interaction with Stat92E negative regulation of R7 cell differentiation ; GO:0045677 | inferred from genetic interaction with sev negative regulation of epidermal growth factor receptor signaling pathway ; GO:0042059 | inferred from mutant phenotype negative regulation of JAK-STAT cascade ; GO:0046426 | inferred from mutant phenotype imaginal disc-derived wing vein morphogenesis ; GO:0008586 | inferred from mutant phenotype cell dedifferentiation ; GO:0043697 | inferred from genetic interaction with bam compound eye pigmentation ; GO:0048072 | inferred from mutant phenotype cytoplasm ; GO:0005737 | inferred from biological aspect of ancestor with PANTHER:PTN000043893 "CG15154, SOCS36E, socs36E, dmSocs36E, SOCS, socs60E1, Socs, dSOCS, clone 2.2, anon-EST:Liang-2.2, Socs36E, SocS36E, socs36e" "IPR000980:SH2 domain, IPR001496:SOCS box domain, IPR028420:Suppressor of cytokine signalling 5" CG15154 27-Aug-18 DroID_v2018_08 "Drer\socs4, Drer\cishb, Drer\socs7, Drer\socs3a, Drer\socs6b, Drer\socs6, Drer\socs1a, Drer\socs1b, Drer\socs5a, Drer\socs5b, Drer\socs9, Drer\socs2, Drer\cish, Drer\socs3b" - - "Xtro\socs3, Xtro\socs3, Xtro\socs4, Xtro\socs2, Xtro\socs6, Xtro\cish, Xtro\socs5, Xtro\socs1" "Mmus\Socs4, Mmus\Socs7, Mmus\Socs3, Mmus\Socs6, Mmus\Cish, Mmus\Socs1, Mmus\Socs5, Mmus\Socs2" "Hsap\SOCS7, Hsap\CISH, Hsap\SOCS1, Hsap\SOCS6, Hsap\SOCS5, Hsap\SOCS3, Hsap\SOCS2, Hsap\SOCS4" "visible,viable,fertile,male semi-sterile,lethal - all die before end of P-stage,partially,some die during pharate adult stage,short lived,memory defective,RU486 conditional" "anterior crossvein,wing vein,ectopic,eye,photoreceptor cell R7,supernumerary,cyst progenitor cell,male,male germline stem cell,somatic clone,border follicle cell,humerus,haltere,pigment cell,wing,germline cell" DRSC02455 IEK 0.507591113 -2.900628656 -1.232231707 2.41611484 -0.768366818 2.089294204 FBgn0034787 CG13535 - http://flybase.org/reports/FBgn0034787 protein_coding_gene - - - CG13535 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0036433 CG9628 - http://flybase.org/reports/FBgn0036433 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG9628 - CG9628 27-Aug-18 DroID_v2018_08 - - - - - - "viable,fertile" FBgn0264656 paltry paltry http://flybase.org/reports/FBgn0264656 gene - "trachea morphogenesis ; GO:0060439 | inferred from mutant phenotype terminal branching, open tracheal system ; GO:0007430 | inferred from mutant phenotype" - paltry - - 27-Aug-18 DroID_v2018_08 - - - - - - "terminal tracheal cell,embryonic/larval tracheal system,eye,somatic clone" FBgn0029715 CG11444 - http://flybase.org/reports/FBgn0029715 protein_coding_gene RNA binding ; GO:0003723 | inferred from sequence or structural similarity with HGNC:14634 biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG11444 "IPR019380:Casein kinase substrate, phosphoprotein PP28" CG11444 27-Aug-18 DroID_v2018_08 "Drer\pdap1b, Drer\pdap1a" - - Xtro\pdap1 Mmus\Pdap1 Hsap\PDAP1 viable FBgn0041707 7B2 7B2 http://flybase.org/reports/FBgn0041707 protein_coding_gene peptidase activator activity ; GO:0016504 | inferred from direct assay neuropeptide signaling pathway ; GO:0007218 | inferred from electronic annotation with InterPro:IPR007945 positive regulation of peptidase activity ; GO:0010952 | inferred from direct assay positive regulation of proteolysis ; GO:0045862 | inferred from direct assay secretory granule ; GO:0030141 | inferred from electronic annotation with InterPro:IPR007945 "d7B2, CG1168, FBgn0040073, 7B2" IPR007945:Neuroendocrine 7B2 precursor CG1168 27-Aug-18 DroID_v2018_08 "Drer\scg5, Drer\scg5" - Cele\sbt-1 Xtro\scg5 Mmus\Scg5 Hsap\SCG5 viable FBgn0044496 DTD45.10 DTD45.10 http://flybase.org/reports/FBgn0044496 gene - - - DTD45.10 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0020418 I-element\RTase I element reverse transcriptase http://flybase.org/reports/FBgn0020418 FBgn0013982 transposable_element_gene "RNA-DNA hybrid ribonuclease activity ; GO:0004523 | inferred from electronic annotation with InterPro:IPR002156 nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR002156, InterPro:IPR012337" - - "ORF2, I\T, I-element\RTase, I-Factor ORF2, ORF2p" "IPR000477:Reverse transcriptase domain, IPR005135:Endonuclease/exonuclease/phosphatase, IPR012337:Ribonuclease H-like domain, IPR002156:Ribonuclease H domain" - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0265064 lncRNA:CR44175 - http://flybase.org/reports/FBgn0265064 non_protein_coding_gene - - - "CR44175, lincRNA.812" - CR44175 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0052123 tRNA:CR32123:Psi transfer RNA:CR32123 pseudogene http://flybase.org/reports/FBgn0052123 pseudogene_attribute - - - "AE002602.trna21-LeuAAG, tRNA:L:AAG:AE002602, tRNA:CR32123:Psi, CR32123" - CR32123 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0028635 ifm(2)RU7 indirect flight muscle (2) RU7 http://flybase.org/reports/FBgn0028635 gene molecular_function ; GO:0003674 | no biological data available muscle organ development ; GO:0007517 | inferred from mutant phenotype polytene chromosome puff ; GO:0005703 | inferred from direct assay ifm(2)RU7 - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,recessive,flight defective,sterile,viable" "wing,dorsal medial muscle,indirect flight muscle & myofibril" FBgn0001385 l(1)2Bq lethal (1) 2Bq http://flybase.org/reports/FBgn0001385 - gene - - - l(1)2Bq - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0267305 lncRNA:CR45741 - http://flybase.org/reports/FBgn0267305 non_protein_coding_gene - - - CR45741 - CR45741 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0259110 mmd mind-meld http://flybase.org/reports/FBgn0259110 protein_coding_gene "metalloendopeptidase activity ; GO:0004222 | inferred from electronic annotation with InterPro:IPR001590, InterPro:IPR002870, InterPro:IPR006586" membrane protein ectodomain proteolysis ; GO:0006509 | inferred from sequence or structural similarity with HGNC:195 integral component of membrane ; GO:0016021 | inferred from sequence or structural similarity with HGNC:195 "mmd, CG42252, CG15603, CG15604, CT26192, CG9163" "IPR018358:Disintegrin, conserved site, IPR000742:EGF-like domain, IPR001590:Peptidase M12B, ADAM/reprolysin, IPR001762:Disintegrin domain, IPR002870:Peptidase M12B, propeptide, IPR006586:ADAM, cysteine-rich, IPR013032:EGF-like, conserved site, IPR034027:Reprolysin domain, adamalysin-type, IPR024079:Metallopeptidase, catalytic domain, IPR013111:EGF-like domain, extracellular" CG42252 27-Aug-18 DroID_v2018_08 "Drer\adam12, Drer\zgc:174164, Drer\adam17b, Drer\adam9, Drer\adam11, Drer\adam28, Drer\adam22, Drer\adam17a, Drer\adam19b, Drer\adam8a, Drer\adam19a, Drer\adam8b, Drer\adam15, Drer\adam23a" - "Cele\tag-275, Cele\unc-71, Cele\adm-4, Cele\K08B4.2, Cele\adm-2, Cele\F27D9.7" "Xtro\adam23, Xtro\adam11, Xtro\adam33, Xtro\adam12, Xtro\adam9" "Mmus\Adam26b, Mmus\Adam1a, Mmus\Adam24, Mmus\Adam19, Mmus\Adam39, Mmus\Adam17, Mmus\Adam15, Mmus\Adam6a, Mmus\Adam12, Mmus\Adam32, Mmus\Adam5, Mmus\Adam20, Mmus\Adam28, Mmus\Adam9, Mmus\Gm4787, Mmus\Adam11, Mmus\Adam3, Mmus\Adam4, Mmus\Adam34, Mmus\Adam22, Mmus\Gm5346, Mmus\Adam33, Mmus\Adam21, Mmus\Adamdec1, Mmus\Adam30, Mmus\Adam2, Mmus\Adam1b, Mmus\Adam25, Mmus\Adam7, Mmus\Adam26a, Mmus\Adam18, Mmus\Adam23, Mmus\Adam29, Mmus\Adam6b, Mmus\Adam8" "Hsap\ADAM8, Hsap\ADAM19, Hsap\ADAMDEC1, Hsap\ADAM11, Hsap\ADAM9, Hsap\ADAM18, Hsap\ADAM2, Hsap\ADAM21, Hsap\ADAM28, Hsap\ADAM23, Hsap\ADAM12, Hsap\ADAM33, Hsap\ADAM29, Hsap\ADAM22, Hsap\ADAM20, Hsap\ADAM17, Hsap\ADAM7, Hsap\ADAM32, Hsap\ADAM30, Hsap\ADAM15" DRSC20161 K 0.349532796 0.981301964 0.50742409 0.704442635 -1.675367721 -0.850084718 FBgn0036785 CG13700 - http://flybase.org/reports/FBgn0036785 protein_coding_gene - - - CG13700 - CG13700 27-Aug-18 DroID_v2018_08 - - Cele\pqn-8 - - - viable FBgn0065134 l(3)SH123 lethal (3) SH123 http://flybase.org/reports/FBgn0065134 gene - - - "l(3)SH123, l(2)SH3 123" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0261001 AGAR-53 Autosomal general anesthetic resistant 53 http://flybase.org/reports/FBgn0261001 gene - - - AGAR-53 - - 27-Aug-18 DroID_v2018_08 - - - - - - "chemical resistant,dominant" FBgn0038677 CG14284 - http://flybase.org/reports/FBgn0038677 protein_coding_gene - - - CG14284 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0065678 l(2)SH0671 lethal (2) SH0671 http://flybase.org/reports/FBgn0065678 gene - - - "l(2)SH0671, l(2)SH2 0671" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0028069 l(3)S090314 lethal (3) S090314 http://flybase.org/reports/FBgn0028069 gene - - - "0903/14, l(3)S090314" - - 27-Aug-18 DroID_v2018_08 - - - - - - "viable,lethal,recessive" FBgn0084568 E-2fa Enhancer on chromosome 2-complementation group fa http://flybase.org/reports/FBgn0084568 gene - - - "E-2f, E-2fa" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0020805 ms(3)1100A male sterile (3) 1100A http://flybase.org/reports/FBgn0020805 - gene - - - ms(3)1100A - - 27-Aug-18 DroID_v2018_08 - - - - - - male sterile FBgn0083283 E(smoDN)2169 Enhancer of smoDN 2169 http://flybase.org/reports/FBgn0083283 gene - - - E(smoDN)2169 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0022972 snRNP42K snRNP42K http://flybase.org/reports/FBgn0022972 - gene - - - "42K, snRNP42K" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0027320 l(1)G0062 lethal (1) G0062 http://flybase.org/reports/FBgn0027320 - gene - - - l(1)G0062 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0069165 mcl(3)Z1492 mcl(3)Z1492 http://flybase.org/reports/FBgn0069165 gene molecular_function ; GO:0003674 | no biological data available male meiosis ; GO:0007140 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available mcl(3)Z1492 - - 27-Aug-18 DroID_v2018_08 - - - - - - male fertile onion stage spermatid & nucleus FBgn0011916 tRNA:Met-CAT-1-2 transfer RNA:Methionine-CAT 1-2 http://flybase.org/reports/FBgn0011916 "FBgn0003807, FBgn0052844, FBgn0060139" tRNA_gene AUG codon-amino acid adaptor activity ; GO:0033436 | inferred from sequence model translation ; GO:0006412 | inferred by curator from GO:0033436 cytosol ; GO:0005829 | inferred by curator from GO:0033436 "CR32844, AE002787.trna22-MetCAT, tRNA:M:CAT:AE002787-b, tRNA:met2:48Bb, chr2R.trna81-MetCAT, tRNA-Met[CAU], tRNA-Met-CAT-1-2, tRNA:Met-CAT-1-2, tRNA:M2:48Bb" - CR32844 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0065628 l(2)SH0791 lethal (2) SH0791 http://flybase.org/reports/FBgn0065628 gene - - - "l(2)SH0791, l(2)SH2 0791" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0016834 l(1)MZ21 lethal (1) MZ21 http://flybase.org/reports/FBgn0016834 - gene - - - "l(1)MZ21, M21" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0051876 Cpr30F Cuticular protein 30F http://flybase.org/reports/FBgn0051876 protein_coding_gene structural constituent of cuticle ; GO:0042302 | inferred from electronic annotation with InterPro:IPR000618 structural constituent of chitin-based larval cuticle ; GO:0008010 | inferred from sequence model chitin-based cuticle development ; GO:0040003 | inferred from sequence model neurogenesis ; GO:0022008 | inferred from mutant phenotype extracellular matrix ; GO:0031012 | inferred from sequence model "CG5879, Cpr30F, CG31876, DmelCpr30F" IPR000618:Insect cuticle protein CG31876 27-Aug-18 DroID_v2018_08 - - Cele\fbxb-38 - - - "lethal,neuroanatomy defective,visible,partially lethal - majority die,some die during pupal stage" "embryonic/larval neuroblast,ganglion mother cell,trichogen cell,mesothoracic tergum" FBgn0001774 l(1)M52 lethal (1) M52 http://flybase.org/reports/FBgn0001774 - gene - - - l(1)M52 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of pupal stage,recessive,some die during pupal stage" FBgn0003568 su(lz[34]) suppressor of lozenge-34 http://flybase.org/reports/FBgn0003568 - gene - - - "su(lz[34k]), su(lz[34])" - - 27-Aug-18 DroID_v2018_08 - - - - - - "female fertile,good" "female accessory gland,spermathecum,eye" FBgn0051864 Qtzl Quetzalcoatl http://flybase.org/reports/FBgn0051864 protein_coding_gene pyridoxal phosphate binding ; GO:0030170 | inferred from electronic annotation with InterPro:IPR010240 cysteine desulfurase activity ; GO:0031071 | inferred from electronic annotation with InterPro:IPR010240 [2Fe-2S] cluster assembly ; GO:0044571 | inferred from electronic annotation with InterPro:IPR010240 - "CG17749, CG31864, CG31864-PA, Qtzl" "IPR000192:Aminotransferase class V domain, IPR015424:Pyridoxal phosphate-dependent transferase, IPR010240:Cysteine desulfurase IscS, IPR015421:Pyridoxal phosphate-dependent transferase, major region, subdomain 1" CG31864 27-Aug-18 DroID_v2018_08 "Drer\scly, Drer\nfs1" Scer\NFS1 "Cele\B0205.6, Cele\F13H8.9" "Xtro\scly, Xtro\nfs1" "Mmus\Scly, Mmus\Nfs1" "Hsap\NFS1, Hsap\SCLY" "viable,sterile,recessive" FBgn0034792 YME1L - http://flybase.org/reports/FBgn0034792 protein_coding_gene "metalloendopeptidase activity ; GO:0004222 | inferred from electronic annotation with InterPro:IPR000642, InterPro:IPR005936 ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR000642, InterPro:IPR003959, InterPro:IPR003960" proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR000642 membrane ; GO:0016020 | inferred from electronic annotation with InterPro:IPR005936 mitochondrion ; GO:0005739 | inferred from direct assay "DmCG3499, YME1L, dYME1L, CG3499" "IPR000642:Peptidase M41, IPR003593:AAA+ ATPase domain, IPR003959:ATPase, AAA-type, core, IPR003960:ATPase, AAA-type, conserved site, IPR005936:Peptidase, FtsH, IPR027417:P-loop containing nucleoside triphosphate hydrolase" CG3499 27-Aug-18 DroID_v2018_08 "Drer\yme1l1a, Drer\spg7, Drer\yme1l1b, Drer\afg3l2" "Scer\YTA12, Scer\AFG3, Scer\YME1" "Cele\ppgn-1, Cele\ymel-1, Cele\spg-7" Xtro\yme1l1 "Mmus\Spg7, Mmus\Afg3l2, Mmus\Yme1l1, Mmus\Afg3l1" "Hsap\AFG3L2, Hsap\YME1L1, Hsap\SPG7" "viable,visible" trichogen cell FBgn0033590 CG13217 - http://flybase.org/reports/FBgn0033590 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "BcDNA:RE32413, CG13217" - CG13217 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0045858 e(Pi3K92E)alpha e(Pi3K92E)alpha http://flybase.org/reports/FBgn0045858 gene - - - "alpha, e(Pi3K92E)alpha" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0041597 l(2)PJ20 lethal (2) PJ20 http://flybase.org/reports/FBgn0041597 gene - - - l(2)PJ20 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0060311 l(3)S147912 lethal (3) S147912 http://flybase.org/reports/FBgn0060311 gene - - - "1479/12, l(3)S147912" - - 27-Aug-18 DroID_v2018_08 - - - - - - "partially lethal - majority die,recessive" FBgn0264397 FCP-E - http://flybase.org/reports/FBgn0264397 gene - - - FCP-E - - 27-Aug-18 DroID_v2018_08 - - - - - - "follicle cell,somatic clone" FBgn0052328 tRNA:Glu-CTC-3-2 transfer RNA:Glutamic acid-CTC 3-2 http://flybase.org/reports/FBgn0052328 tRNA_gene GAG codon-amino acid adaptor activity ; GO:0033460 | inferred from sequence model translation ; GO:0006412 | inferred by curator from GO:0033460 cytosol ; GO:0005829 | inferred by curator from GO:0033460 "CR32328, AE002584.trna4-GluCTC, tRNA:E:CTC:AE002584-b, chr3L.trna4-GluCTC, tRNA:Glu-CTC-3-2, tRNA:CR32328, tRNA-Glu-CTC-3-2, GAG" - CR32328 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0030262 Vago Vago http://flybase.org/reports/FBgn0030262 protein_coding_gene - defense response to virus ; GO:0051607 | inferred from mutant phenotype defense response to virus ; GO:0051607 | inferred from expression pattern extracellular space ; GO:0005615 | inferred from sequence model "CG2081, BcDNA:RH70969, Vago, DIGF-2" IPR029277:Single domain Von Willebrand factor type C domain CG2081 27-Aug-18 DroID_v2018_08 - - - - - - "viable,fertile" FBgn0051432 tRNA:Thr-TGT-2-5 transfer RNA:Threonine-TGT 2-5 http://flybase.org/reports/FBgn0051432 tRNA_gene ACA codon-amino acid adaptor activity ; GO:0033439 | inferred from sequence model translation ; GO:0006412 | inferred by curator from GO:0033439 cytosol ; GO:0005829 | inferred by curator from GO:0033439 "AE002708.trna55-ThrTGT, tRNA[Thr][[3]], tRNA:thr3:87BC, tRNA:T3:87BC, tRNA:T:TGT:AE002708-b, CR31432, tRNA[[Thr]], chr3R.trna61-ThrTGT, tRNA-Thr-TGT-2-5, tRNA:Thr-TGT-2-5, tRNA:CR31432, ACA" - CR31432 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0031455 Snapin SNAP associated protein http://flybase.org/reports/FBgn0031455 protein_coding_gene protein binding ; GO:0005515 | inferred from physical interaction with Dysb intracellular protein transport ; GO:0006886 | inferred from electronic annotation with InterPro:IPR017246 neurotransmitter secretion ; GO:0007269 | non-traceable author statement synaptic vesicle exocytosis ; GO:0016079 | inferred from sequence or structural similarity regulation of homeostatic process ; GO:0032844 | inferred from mutant phenotype synaptic vesicle priming ; GO:0016082 | non-traceable author statement BLOC-1 complex ; GO:0031083 | inferred from sequence or structural similarity with HGNC:17145 synaptic vesicle ; GO:0008021 | inferred from direct assay synaptic vesicle ; GO:0008021 | non-traceable author statement "CG9958, CG32951, snapin, Dromel_CG9960_CG9958_FBtr007773_snapin_uORF, Snapin, NP_722835, SNAPIN" "IPR017246:Snapin, IPR028119:Snapin/Pallidin/Snn1" CG9958 27-Aug-18 DroID_v2018_08 Drer\snapin - Cele\snpn-1 Xtro\snapin Mmus\Snapin Hsap\SNAPIN "lethal - all die before end of pupal stage,some die during pupal stage,neurophysiology defective,drug conditional,female fertile" DRSC00736 E -0.117033922 0.993273659 1.590928682 0.825585157 0.007598632 -0.001642737 FBgn0052455 CG32455 - http://flybase.org/reports/FBgn0052455 protein_coding_gene - - - CG32455 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0002752 mit(1)2 mitotic 2 http://flybase.org/reports/FBgn0002752 - gene molecular_function ; GO:0003674 | no biological data available mitotic nuclear division ; GO:0007067 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available mit(1)2 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,heat sensitive" FBgn0083048 snoRNA:Psi18S-1377d snoRNA:Psi18S-1377d http://flybase.org/reports/FBgn0083048 snoRNA_gene - - - "snoRNA:Psi18S-1377d, Psi18S-1377d, psi18S-1377d, CR34626, chr3R:26032931..26033021" - CR34626 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0263231 bel belle http://flybase.org/reports/FBgn0263231 protein_coding_gene ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR011545 nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR011545 ATP-dependent RNA helicase activity ; GO:0004004 | inferred from mutant phenotype ATP-dependent RNA helicase activity ; GO:0004004 | inferred from sequence or structural similarity with SGD:S000005730 regulation of gene expression ; GO:0010468 | inferred from mutant phenotype RNA secondary structure unwinding ; GO:0010501 | inferred from biological aspect of ancestor with PANTHER:PTN000618218 ecdysone-mediated induction of salivary gland cell autophagic cell death ; GO:0035072 | inferred from mutant phenotype mitotic sister chromatid segregation ; GO:0000070 | inferred from mutant phenotype translational initiation ; GO:0006413 | inferred from biological aspect of ancestor with PANTHER:PTN000619593 instar larval development ; GO:0002168 | inferred from mutant phenotype oogenesis ; GO:0048477 | inferred from mutant phenotype spermatogenesis ; GO:0007283 | inferred from mutant phenotype RNA interference ; GO:0016246 | inferred from mutant phenotype spermatid development ; GO:0007286 | inferred from mutant phenotype male germ-line stem cell population maintenance ; GO:0036098 | inferred from mutant phenotype microtubule associated complex ; GO:0005875 | inferred from direct assay P granule ; GO:0043186 | inferred from direct assay neuronal cell body ; GO:0043025 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay RISC complex ; GO:0016442 | inferred from direct assay lipid particle ; GO:0005811 | inferred from direct assay cytosol ; GO:0005829 | inferred from direct assay "psg9, bel, BEL, CG9748, DmRH6, cg9748, cap, ms(3)neo30, l(3)85Ac, L3, anon-85Ab, ms(3)Pneo85A, l(3)L3, belle, l(3)S097074, l(3)S047110, l(3)L4740, Bel" "IPR014001:Helicase superfamily 1/2, ATP-binding domain, IPR014014:RNA helicase, DEAD-box type, Q motif, IPR000629:ATP-dependent RNA helicase DEAD-box, conserved site, IPR001650:Helicase, C-terminal, IPR011545:DEAD/DEAH box helicase domain, IPR027417:P-loop containing nucleoside triphosphate hydrolase" CG9748 27-Aug-18 DroID_v2018_08 "Drer\ddx3a, Drer\ddx3b" "Scer\MRH4, Scer\DBP1, Scer\DED1" "Cele\glh-1, Cele\vbh-1, Cele\glh-3, Cele\laf-1, Cele\glh-2" Xtro\ddx3x "Mmus\Ddx3x, Mmus\Ddx3y, Mmus\Ddx4, Mmus\D1Pas1" "Hsap\DDX3Y, Hsap\DDX3X, Hsap\DDX4" DRSC25066 IK -2.737597649 -0.844103717 -0.809998272 0.190823138 0.35739607 3.248510243 FBgn0036192 Pldn Pallidin http://flybase.org/reports/FBgn0036192 protein_coding_gene protein binding ; GO:0005515 | inferred from physical interaction with Blos1 eye pigment granule organization ; GO:0008057 | inferred from mutant phenotype intracellular transport ; GO:0046907 | inferred from biological aspect of ancestor with PANTHER:PTN001583105 BLOC-1 complex ; GO:0031083 | inferred from sequence or structural similarity with HGNC:8549 BLOC-1 complex ; GO:0031083 | inferred from biological aspect of ancestor with PANTHER:PTN001583105 transport vesicle ; GO:0030133 | inferred from biological aspect of ancestor with PANTHER:PTN001583105 extrinsic component of membrane ; GO:0019898 | inferred from biological aspect of ancestor with PANTHER:PTN001583105 "CG14133, Pallidin, NP_648494, pallidin, Pldn, pldn" "IPR017242:BLOC-1 complex, pallidin subunit, IPR028119:Snapin/Pallidin/Snn1" CG14133 27-Aug-18 DroID_v2018_08 Drer\bloc1s6 - - Xtro\bloc1s6 Mmus\Bloc1s6 Hsap\BLOC1S6 "eye color defective,viable" FBgn0067329 3F43 3F43 http://flybase.org/reports/FBgn0067329 gene molecular_function ; GO:0003674 | no biological data available imaginal disc-derived wing margin morphogenesis ; GO:0008587 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available 3F43 - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,somatic clone" "wing sensillum,ectopic,somatic clone" FBgn0085540 lncRNA:CR40947 - http://flybase.org/reports/FBgn0085540 non_protein_coding_gene - - - "CR40947, CG40947" - CR40947 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0051913 CG31913 - http://flybase.org/reports/FBgn0051913 protein_coding_gene RNA binding ; GO:0003723 | inferred from biological aspect of ancestor with PANTHER:PTN000080456 structural constituent of ribosome ; GO:0003735 | inferred from biological aspect of ancestor with PANTHER:PTN000080456 translation ; GO:0006412 | inferred from biological aspect of ancestor with PANTHER:PTN000080456 cytosolic large ribosomal subunit ; GO:0022625 | inferred from biological aspect of ancestor with PANTHER:PTN000080456 "NEST:bs23g06, NEST:bs28e01, NEST:bs35c08, NEST:bs14h07, NEST:bs09g05, CG31913" IPR014807:Cytochrome oxidase assembly protein 1 CG31913 27-Aug-18 DroID_v2018_08 "Drer\coa1, Drer\rpl37" "Scer\RPL37A, Scer\RPL37B" "Cele\T23F2.2, Cele\Y38C1AA.14" Xtro\coa1 - Hsap\COA1 viable FBgn0026224 l(1)16Fq lethal (1) 16Fq http://flybase.org/reports/FBgn0026224 - gene - - - "ME-V, l(1)16Fq" - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0065653 l(2)SH0728 lethal (2) SH0728 http://flybase.org/reports/FBgn0065653 gene - - - "l(2)SH0728, l(2)SH2 0728" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0259711 CG42365 - http://flybase.org/reports/FBgn0259711 protein_coding_gene - - - "CG42365, CG15675" - CG42365 27-Aug-18 DroID_v2018_08 - - - - - - "visible,partially lethal - majority die,some die during pupal stage" "chaeta,supernumerary" FBgn0011060 l(1)Q13 lethal (1) Q13 http://flybase.org/reports/FBgn0011060 FBgn0010210 gene - - - l(1)Q13 - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0040553 CG14374 - http://flybase.org/reports/FBgn0040553 protein_coding_gene - - - CG14374 - CG14374 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0010401 Os-C Os-C http://flybase.org/reports/FBgn0010401 - protein_coding_gene - biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "Os-c, OS-C, CG3250, Os-C" - CG3250 27-Aug-18 DroID_v2018_08 - - - - - - adult stage " sacculus

, antennal segment 3

" "viable,visible,body color defective" "trichogen cell,mesothoracic tergum" FBgn0058040 CG40040 - http://flybase.org/reports/FBgn0058040 protein_coding_gene - - - CG40040 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0002750 misp misstep http://flybase.org/reports/FBgn0002750 - gene molecular_function ; GO:0003674 | no biological data available embryonic development via the syncytial blastoderm ; GO:0001700 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available misp - - 27-Aug-18 DroID_v2018_08 - - - - - - "female sterile,recessive,lethal - all die before end of embryonic stage,maternal effect,some die during embryonic stage" "embryonic/first instar larval cuticle,maternal effect,embryonic segment" FBgn0033729 Cpr49Af Cuticular protein 49Af http://flybase.org/reports/FBgn0033729 protein_coding_gene structural constituent of cuticle ; GO:0042302 | inferred from biological aspect of ancestor with PANTHER:PTN000822475 structural constituent of chitin-based larval cuticle ; GO:0008010 | inferred from sequence model chitin-based cuticle development ; GO:0040003 | inferred from sequence model extracellular matrix ; GO:0031012 | inferred from sequence model "Cpr49Af, CG8510, DmelCpr49Af" "IPR000618:Insect cuticle protein, IPR031311:Chitin-binding type R&R consensus" CG8510 27-Aug-18 DroID_v2018_08 Drer\LOC100003040 - "Cele\sdz-30, Cele\math-34, Cele\F44F1.4" - "Mmus\H2-K1, Mmus\2410137M14Rik" - FBgn0037964 CG14731 - http://flybase.org/reports/FBgn0037964 protein_coding_gene "catalytic activity ; GO:0003824 | inferred from electronic annotation with InterPro:IPR017849, InterPro:IPR017850" "metabolic process ; GO:0008152 | inferred from electronic annotation with InterPro:IPR017849, InterPro:IPR017850" - "CG14731, gi7299531, gi21483202" "IPR004245:Protein of unknown function DUF229, IPR017850:Alkaline-phosphatase-like, core domain, IPR017849:Alkaline phosphatase-like, alpha/beta/alpha" CG14731 27-Aug-18 DroID_v2018_08 - - "Cele\M03F8.5, Cele\F32D8.2, Cele\R03G8.1, Cele\F10C2.3, Cele\Y41E3.1, Cele\F07C3.3, Cele\F15H10.7, Cele\T23E1.1, Cele\R03G8.3, Cele\Y38A10A.2, Cele\K03A11.4, Cele\T07G12.3, Cele\F32G8.2, Cele\Y73F8A.35" - - - "viable,fertile" FBgn0046118 E(To)8 E(To)8 http://flybase.org/reports/FBgn0046118 gene - - - E(To)8 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0028214 l(3)S009720 lethal (3) S009720 http://flybase.org/reports/FBgn0028214 gene - - - "0097/20, l(3)S009720" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0033865 CG6220 - http://flybase.org/reports/FBgn0033865 protein_coding_gene "transcription factor activity, RNA polymerase II transcription factor binding ; GO:0001076 | inferred from sequence or structural similarity with SGD:S000004410 transcription factor activity, RNA polymerase II transcription factor binding ; GO:0001076 | inferred from biological aspect of ancestor with PANTHER:PTN000279609 RNA polymerase II core binding ; GO:0000993 | inferred from biological aspect of ancestor with PANTHER:PTN000279609" negative regulation of transcription from RNA polymerase II promoter ; GO:0000122 | inferred from sequence or structural similarity with HGNC:16783 recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex ; GO:0034402 | inferred from biological aspect of ancestor with PANTHER:PTN000279609 positive regulation of transcription elongation from RNA polymerase II promoter ; GO:0032968 | inferred from biological aspect of ancestor with PANTHER:PTN000279609 histone modification ; GO:0016570 | inferred from biological aspect of ancestor with PANTHER:PTN000279609 Cdc73/Paf1 complex ; GO:0016593 | inferred from sequence or structural similarity with SGD:S000004410 Cdc73/Paf1 complex ; GO:0016593 | inferred from biological aspect of ancestor with PANTHER:PTN000279609 nucleus ; GO:0005634 | inferred from sequence or structural similarity with HGNC:16783 CG6220 "IPR007852:Cdc73/Parafibromin, IPR031336:Cell division control protein 73, C-terminal, IPR032041:Paf1 complex subunit Cdc73, N-terminal domain" CG6220 27-Aug-18 DroID_v2018_08 Drer\cdc73 Scer\CDC73 Cele\cdc-73 Xtro\cdc73 Mmus\Cdc73 Hsap\CDC73 viable FBgn0011231 sdl seedless http://flybase.org/reports/FBgn0011231 - gene - spermatid development ; GO:0007286 | inferred from mutant phenotype - sdl - - 27-Aug-18 DroID_v2018_08 - - - - - - "male sterile,recessive" FBgn0032925 CG9246 - http://flybase.org/reports/FBgn0032925 protein_coding_gene transcription corepressor activity ; GO:0003714 | inferred from biological aspect of ancestor with PANTHER:PTN000976013 histone binding ; GO:0042393 | inferred from biological aspect of ancestor with PANTHER:PTN000976013 repressing transcription factor binding ; GO:0070491 | inferred from biological aspect of ancestor with PANTHER:PTN000976013 neurogenesis ; GO:0022008 | inferred from mutant phenotype ribosomal large subunit biogenesis ; GO:0042273 | inferred from biological aspect of ancestor with PANTHER:PTN000293925 negative regulation of histone acetylation ; GO:0035067 | inferred from biological aspect of ancestor with PANTHER:PTN000976013 negative regulation of transcription from RNA polymerase II promoter ; GO:0000122 | inferred from biological aspect of ancestor with PANTHER:PTN000976013 nucleolus ; GO:0005730 | inferred from biological aspect of ancestor with PANTHER:PTN000293925 nucleoplasm ; GO:0005654 | inferred from biological aspect of ancestor with PANTHER:PTN000293925 nucleolus ; GO:0005730 | inferred from sequence or structural similarity with HGNC:24517 Noc2p-Noc3p complex ; GO:0030691 | inferred from biological aspect of ancestor with PANTHER:PTN000293925 Noc1p-Noc2p complex ; GO:0030690 | inferred from biological aspect of ancestor with PANTHER:PTN000293925 CG9246 "IPR005343:Nucleolar complex protein 2, IPR016024:Armadillo-type fold, IPR011989:Armadillo-like helical" CG9246 27-Aug-18 DroID_v2018_08 Drer\noc2l Scer\NOC2 Cele\pro-2 Xtro\noc2l Mmus\Noc2l Hsap\NOC2L "lethal,neuroanatomy defective,visible,partially lethal - majority die,some die during pupal stage" "embryonic/larval neuroblast,ganglion mother cell,mesothoracic tergum" FBgn0002789 Mp20 Muscle protein 20 http://flybase.org/reports/FBgn0002789 "FBgn0003740, FBgn0026854" protein_coding_gene actin binding ; GO:0003779 | inferred from sequence or structural similarity myoblast fusion ; GO:0007520 | inferred from mutant phenotype cell adhesion ; GO:0007155 | inferred from mutant phenotype regulation of cell shape ; GO:0008360 | inferred from mutant phenotype regulation of myoblast fusion ; GO:1901739 | inferred from mutant phenotype - "DMMP20, Dmmp20, CG4696, mp20, Tpn, Mp20, MP20" "IPR000557:Calponin repeat, IPR001715:Calponin homology domain, IPR003096:Smooth muscle protein/calponin" CG4696 27-Aug-18 DroID_v2018_08 "Drer\cnn2, Drer\cnn3b, Drer\cnn1b, Drer\tagln3b, Drer\tagln2, Drer\tagln, Drer\cnn3a, Drer\tagln3a, Drer\cnn1a, Drer\iqgap2" "Scer\SCP1, Scer\IQG1" "Cele\cpn-2, Cele\pes-7, Cele\cpn-1, Cele\cpn-3" "Xtro\tagln2, Xtro\cnn3, Xtro\cnn1, Xtro\tagln, Xtro\cnn2" "Mmus\Cnn2, Mmus\Iqgap1, Mmus\Iqgap3, Mmus\Cnn3, Mmus\Tagln2, Mmus\Cnn1, Mmus\Tagln, Mmus\Tagln3" "Hsap\CNN3, Hsap\CNN2, Hsap\TAGLN2, Hsap\TAGLN, Hsap\IQGAP1, Hsap\TAGLN3, Hsap\IQGAP3, Hsap\CNN1" " embryonic stage | 12-24 hr , adult stage , prepupal stage , pupal stage | early " adult stage synchronous muscle

"viable,visible" "dorsal acute muscle 1,nucleus | supernumeraryeve.eme,trichogen cell,supernumerary,tormogen cell,embryonic myoblast,dorsal transverse muscle,ventral acute muscle 2,segment border muscle,nucleushow-24B" FBgn0051675 CG31675 - http://flybase.org/reports/FBgn0051675 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "BcDNA:RE19849, CG31675" - CG31675 27-Aug-18 DroID_v2018_08 - - "Cele\C15H9.9, Cele\K11H12.6, Cele\K11H12.7" - - - viable FBgn0026380 Prosbeta3 Proteasome beta3 subunit http://flybase.org/reports/FBgn0026380 - protein_coding_gene "threonine-type endopeptidase activity ; GO:0004298 | inferred from electronic annotation with InterPro:IPR001353, InterPro:IPR023333 endopeptidase activity ; GO:0004175 | contributes_to inferred by curator from GO:0005839" neurogenesis ; GO:0022008 | inferred from mutant phenotype cellular response to DNA damage stimulus ; GO:0006974 | inferred from mutant phenotype proteasome-mediated ubiquitin-dependent protein catabolic process ; GO:0043161 | inferred from mutant phenotype proteasome-mediated ubiquitin-dependent protein catabolic process ; GO:0043161 | inferred by curator from GO:0005839 "proteasome core complex, beta-subunit complex ; GO:0019774 | inferred from electronic annotation with InterPro:IPR033811 proteasome core complex ; GO:0005839 | inferred from direct assay proteasome complex ; GO:0000502 | inferred from direct assay" "Prosbeta3, CG11981, 11981, Beta-3, beta3, Pros beta3, beta-3" "IPR001353:Proteasome, subunit alpha/beta, IPR016050:Proteasome beta-type subunit, conserved site, IPR023333:Proteasome B-type subunit, IPR033811:Proteasome beta 3 subunit, IPR029055:Nucleophile aminohydrolases, N-terminal" CG11981 27-Aug-18 DroID_v2018_08 "Drer\psmb3, Drer\p4hb" Scer\PUP3 Cele\pbs-3 Xtro\psmb3 Mmus\Psmb3 Hsap\PSMB3 "lethal,neuroanatomy defective" "embryonic/larval neuroblast,ganglion mother cell" DRSC16801 IE -3.090109855 -5.477058347 -3.845298976 -2.891937368 1.281761475 -0.036620931 FBgn0002206 l(3)67BDd lethal (3) 67BDd http://flybase.org/reports/FBgn0002206 - gene - - - l(3)67BDd - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of larval stage,some die during larval stage" FBgn0014364 myoblast-specific myoblast specific http://flybase.org/reports/FBgn0014364 - gene - - - "mas, myoblast-specific" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0040487 BobA Brother of Bearded A http://flybase.org/reports/FBgn0040487 protein_coding_gene protein binding ; GO:0005515 | inferred from physical interaction with neur Notch signaling pathway ; GO:0007219 | inferred from mutant phenotype sensory organ development ; GO:0007423 | inferred from mutant phenotype sensory organ precursor cell fate determination ; GO:0016360 | inferred from mutant phenotype cell fate specification ; GO:0001708 | inferred from mutant phenotype defense response to bacterium ; GO:0042742 | inferred from mutant phenotype - "CG12487, bobA, Bob-A, Bob, BobA" - CG12487 27-Aug-18 DroID_v2018_08 - - - - - - "viable,fertile,visible,lethal" "macrochaeta,microchaeta,external sensory organ precursor cell & dorsal mesothoracic disc-537.4,wing sensillum & wing veinBx-MS1096,wing margin bristle,wing sensillum & wing vein69B,tormogen cell,trichogen cell" FBgn0011660 Pms2 Pms2 http://flybase.org/reports/FBgn0011660 FBgn0024325 protein_coding_gene "mismatched DNA binding ; GO:0030983 | inferred from electronic annotation with InterPro:IPR002099, InterPro:IPR013507 ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR002099, InterPro:IPR013507, InterPro:IPR014790 ATPase activity ; GO:0016887 | inferred from biological aspect of ancestor with PANTHER:PTN000008161 single-stranded DNA binding ; GO:0003697 | inferred from biological aspect of ancestor with PANTHER:PTN000008161" mismatch repair ; GO:0006298 | inferred from biological aspect of ancestor with PANTHER:PTN000008161 MutLalpha complex ; GO:0032389 | inferred from biological aspect of ancestor with PANTHER:PTN000008284 microtubule associated complex ; GO:0005875 | inferred from direct assay "pms2, dmlh2, dmlh-2, dpms2, Mlh2, CG8169, Pms2" "IPR002099:DNA mismatch repair protein family, IPR003594:Histidine kinase-like ATPase, C-terminal domain, IPR013507:DNA mismatch repair protein, C-terminal, IPR014721:Ribosomal protein S5 domain 2-type fold, subgroup, IPR014762:DNA mismatch repair, conserved site, IPR014790:MutL, C-terminal, dimerisation, IPR020568:Ribosomal protein S5 domain 2-type fold, IPR028831:DNA mismatch repair protein Pms1" CG8169 27-Aug-18 DroID_v2018_08 "Drer\pms2, Drer\pms1, Drer\rsph10b" "Scer\PMS1, Scer\MLH2" Cele\pms-2 "Xtro\rsph10b, Xtro\pms2, Xtro\pms1" "Mmus\Pms1, Mmus\Lef1, Mmus\Pms2" "Hsap\RSPH10B2, Hsap\PMS1, Hsap\PMS2, Hsap\LOC107984056, Hsap\LEF1, Hsap\RSPH10B" viable FBgn0267044 CG45488 - http://flybase.org/reports/FBgn0267044 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG45488 - CG45488 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0031873 Gas41 Gas41 http://flybase.org/reports/FBgn0031873 protein_coding_gene histone acetyltransferase activity ; GO:0004402 | contributes_to inferred from direct assay heterochromatin organization involved in chromatin silencing ; GO:0070868 | inferred from mutant phenotype RNA interference ; GO:0016246 | inferred from mutant phenotype protein localization to heterochromatin ; GO:0097355 | inferred from mutant phenotype transcription initiation from RNA polymerase II promoter ; GO:0006367 | inferred from sequence or structural similarity with HGNC:7134 inferred from sequence or structural similarity with HGNC:7136 inferred from sequence or structural similarity with SGD:S000005051 inferred from sequence or structural similarity with SGD:S000006050 histone exchange ; GO:0043486 | inferred from direct assay histone acetylation ; GO:0016573 | inferred from direct assay histone acetyltransferase complex ; GO:0000123 | inferred from physical interaction with pont NuA4 histone acetyltransferase complex ; GO:0035267 | inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay transcription factor TFIID complex ; GO:0005669 | inferred from sequence or structural similarity with HGNC:7134 inferred from sequence or structural similarity with HGNC:7136 inferred from sequence or structural similarity with SGD:S000005051 inferred from sequence or structural similarity with SGD:S000006050 nucleus ; GO:0005634 | inferred from sequence or structural similarity with HGNC:24859 "GAS41, dGas41, CG9207, Gas41" IPR005033:YEATS CG9207 27-Aug-18 DroID_v2018_08 "Drer\mllt1a, Drer\mllt1b, Drer\mllt3, Drer\yeats4, Drer\yeats2" "Scer\SAS5, Scer\YAF9, Scer\TAF14" "Cele\gfl-1, Cele\Y105E8B.7" "Xtro\mllt3, Xtro\mllt1, Xtro\yeats2, Xtro\yeats4" "Mmus\Mllt3, Mmus\Yeats4, Mmus\Mllt1, Mmus\Yeats2" "Hsap\MLLT3, Hsap\YEATS2, Hsap\MLLT1, Hsap\YEATS4" viable FBgn0020608 anon-12Db anon-12Db http://flybase.org/reports/FBgn0020608 - gene - - - "D1, anon-12Db" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0259332 C434.2 - http://flybase.org/reports/FBgn0259332 gene - - - C434.2 - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,lethal" "wing vein,wing hair,chaeta" FBgn0032613 CG13283 - http://flybase.org/reports/FBgn0032613 protein_coding_gene metalloendopeptidase activity ; GO:0004222 | inferred from electronic annotation with InterPro:IPR000718 proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR000718 - CG13283 "IPR024079:Metallopeptidase, catalytic domain, IPR000718:Peptidase M13" CG13283 27-Aug-18 DroID_v2018_08 "Drer\ece2b, Drer\ece1, Drer\phex, Drer\mmel1" - "Cele\nep-24, Cele\nep-6" "Xtro\ecel1, Xtro\ece1, Xtro\mmel1, Xtro\ece2" "Mmus\Phex, Mmus\Ecel1, Mmus\Ece1, Mmus\Mmel1, Mmus\Ece2, Mmus\Mme, Mmus\Kel" "Hsap\ECEL1, Hsap\MMEL1, Hsap\KEL, Hsap\PHEX, Hsap\ECE1, Hsap\MME, Hsap\ECE2" viable FBgn0060357 l(3)S140713a lethal (3) S140713a http://flybase.org/reports/FBgn0060357 gene - - - "1407/13, l(3)S140713a" - - 27-Aug-18 DroID_v2018_08 - - - - - - "partially lethal - majority die,recessive,lethal" FBgn0005138 l(2)74i lethal (2) 74i http://flybase.org/reports/FBgn0005138 - gene - - - l(2)74i - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0037466 CG1965 - http://flybase.org/reports/FBgn0037466 protein_coding_gene "transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding ; GO:0001078 | inferred from biological aspect of ancestor with PANTHER:PTN000259143 RNA polymerase II core promoter proximal region sequence-specific DNA binding ; GO:0000978 | inferred from biological aspect of ancestor with PANTHER:PTN000259143" "regulation of transcription, DNA-templated ; GO:0006355 | inferred from electronic annotation with InterPro:IPR012890, InterPro:IPR022783 mRNA splicing, via spliceosome ; GO:0000398 | inferred by curator from GO:0071011,GO:0071013" precatalytic spliceosome ; GO:0071011 | inferred from direct assay catalytic step 2 spliceosome ; GO:0071013 | inferred from direct assay CG1965 "IPR012890:GC-rich sequence DNA-binding factor, IPR022783:GC-rich sequence DNA-binding factor domain" CG1965 27-Aug-18 DroID_v2018_08 "Drer\zgc:158234, Drer\gcfc2" - Cele\F43G9.12 "Xtro\paxbp1, Xtro\gcfc2" "Mmus\Paxbp1, Mmus\Gcfc2" "Hsap\PAXBP1, Hsap\GCFC2" lethal FBgn0035718 CG14820 - http://flybase.org/reports/FBgn0035718 protein_coding_gene zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR000834 metallocarboxypeptidase activity ; GO:0004181 | inferred from biological aspect of ancestor with PANTHER:PTN000194073 protein binding ; GO:0005515 | inferred from physical interaction with egg "proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR000834, InterPro:IPR003146" extracellular space ; GO:0005615 | inferred from biological aspect of ancestor with PANTHER:PTN000194073 CG14820 "IPR000834:Peptidase M14, carboxypeptidase A, IPR009020:Protease propeptides/proteinase inhibitor I9, IPR034223:Insect gut carboxypeptidase-like, carboxypeptidase domain, IPR003146:Carboxypeptidase, activation peptide" CG14820 27-Aug-18 DroID_v2018_08 "Drer\cpa2, Drer\cpa6, Drer\cpa4, Drer\cpb2, Drer\cpo, Drer\cpa5, Drer\cpb1, Drer\cpa1" Scer\ECM14 "Cele\W01A8.6, Cele\ZC434.9, Cele\Y59C2A.1, Cele\F02D8.4, Cele\suro-1, Cele\Y47G6A.19, Cele\T06A4.3, Cele\T06A4.1, Cele\Y18H1A.9" "Xtro\cpa1, Xtro\LOC100487462, Xtro\LOC100489361, Xtro\cpo, Xtro\cpb1, Xtro\cpb2, Xtro\cpa3" "Mmus\Cpb2, Mmus\Cpa6, Mmus\Cpa4, Mmus\Cpa5, Mmus\Cpa2, Mmus\Cpb1, Mmus\Cpa3, Mmus\Cpa1" "Hsap\CPA5, Hsap\CPB1, Hsap\CPA2, Hsap\CPB2, Hsap\CPA6, Hsap\CPA3, Hsap\CPO, Hsap\CPA4, Hsap\CPA1" "partially lethal - majority die,some die during pupal stage" FBgn0035760 CG8607 - http://flybase.org/reports/FBgn0035760 protein_coding_gene "catalytic activity ; GO:0003824 | inferred from electronic annotation with InterPro:IPR011060, InterPro:IPR013785" metabolic process ; GO:0008152 | inferred from electronic annotation with InterPro:IPR011060 - CG8607 "IPR005137:Membrane complex biogenesis protein, BtpA family, IPR011060:Ribulose-phosphate binding barrel" CG8607 27-Aug-18 DroID_v2018_08 Drer\zgc:162297 - "Cele\fipr-15, Cele\F13E9.13" Xtro\LOC549154 - - viable FBgn0052736 CG32736 - http://flybase.org/reports/FBgn0052736 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG32736, CG14429, BcDNA:RE60462" IPR028183:Uncharacterised protein family UPF0640 CG32736 27-Aug-18 DroID_v2018_08 "Drer\smim4, Drer\si:ch211-68a17.7, Drer\lin37" - Cele\lin-37 Xtro\lin37 Mmus\Smim4 "Hsap\C12orf73, Hsap\LIN37, Hsap\SMIM4" FBgn0065673 l(2)SH0678 lethal (2) SH0678 http://flybase.org/reports/FBgn0065673 gene - - - "l(2)SH0678, l(2)SH2 0678" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0031020 Naa15-16 N(alpha)-acetyltransferase 15/16 http://flybase.org/reports/FBgn0031020 protein_coding_gene peptide alpha-N-acetyltransferase activity ; GO:0004596 | contributes_to inferred from biological aspect of ancestor with PANTHER:PTN000511059 N-terminal peptidyl-methionine acetylation ; GO:0017196 | inferred from biological aspect of ancestor with PANTHER:PTN000511059 neurogenesis ; GO:0022008 | inferred from mutant phenotype mitotic spindle ; GO:0072686 | inferred from direct assay NatA complex ; GO:0031415 | inferred from biological aspect of ancestor with PANTHER:PTN000511117 NatA complex ; GO:0031415 | inferred from direct assay protein acetyltransferase complex ; GO:0031248 | inferred from physical interaction with UniProtKB:Q9NHD5 "CG12202, dNat1, l(1)G0311, Nat1, Naa15, dNaa15, Naa15-16, Naa15/16, NAA15-16" "IPR011990:Tetratricopeptide-like helical domain, IPR013026:Tetratricopeptide repeat-containing domain, IPR019734:Tetratricopeptide repeat, IPR021183:N-terminal acetyltransferase A, auxiliary subunit" CG12202 27-Aug-18 DroID_v2018_08 "Drer\naa15a, Drer\naa15b" Scer\NAT1 Cele\hpo-29 "Xtro\naa15, Xtro\naa16" "Mmus\Naa15, Mmus\Naa16" "Hsap\NAA16, Hsap\NAA15" "viable,fertile,lethal,recessive,neuroanatomy defective" "embryonic/larval neuroblast,ganglion mother cell" DRSC19440 IE 1.118109638 2.123228374 1.101715375 1.73970854 0.055528706 -0.511190298 FBgn0034617 Panx Panoramix http://flybase.org/reports/FBgn0034617 protein_coding_gene molecular_function ; GO:0003674 | no biological data available piRNA biosynthetic process ; GO:1990511 | inferred from direct assay positive regulation of methylation-dependent chromatin silencing ; GO:0090309 | inferred from direct assay inferred from mutant phenotype nucleus ; GO:0005634 | inferred from direct assay "CG9754, Panx, pan, Silencio" - CG9754 27-Aug-18 DroID_v2018_08 - - - - - - "viable,female sterile" FBgn0046839 l(3)A4-4L1 lethal (3) A4-4L1 http://flybase.org/reports/FBgn0046839 gene - - - l(3)A4-4L1 - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0263845 lncRNA:CR43706 - http://flybase.org/reports/FBgn0263845 non_protein_coding_gene - - - CR43706 - CR43706 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0265921 lncRNA:CR44710 - http://flybase.org/reports/FBgn0265921 non_protein_coding_gene - - - "CR44710, lincRNA.1029" - CR44710 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0262580 CG43120 - http://flybase.org/reports/FBgn0262580 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG43120 "IPR000210:BTB/POZ domain, IPR011333:SKP1/BTB/POZ domain" CG43120 27-Aug-18 DroID_v2018_08 "Drer\btbd6b, Drer\btbd17b, Drer\btbd6a, Drer\btbd2, Drer\btbd3a, Drer\btbd3b" - - "Xtro\btbd1, Xtro\btbd2, Xtro\btbd3, Xtro\btbd6" "Mmus\Btbd6, Mmus\Btbd17, Mmus\Btbd1, Mmus\Btbd2, Mmus\Btbd3" "Hsap\BTBD3, Hsap\BTBD1, Hsap\BTBD2, Hsap\BTBD17, Hsap\BTBD6" FBgn0000195 blc blocked http://flybase.org/reports/FBgn0000195 - gene molecular_function ; GO:0003674 | no biological data available oogenesis ; GO:0048477 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available blc - - 27-Aug-18 DroID_v2018_08 - - - - - - "female sterile,male sterile" "germline cell,female" FBgn0000687 flrdJ flight reduced J http://flybase.org/reports/FBgn0000687 - gene molecular_function ; GO:0003674 | no biological data available flight behavior ; GO:0007629 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available "flrdI, flrdJ" - - 27-Aug-18 DroID_v2018_08 - - - - - - flight defective FBgn0022935 D19A D19A http://flybase.org/reports/FBgn0022935 - protein_coding_gene "zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR012934 transcription factor activity, sequence-specific DNA binding ; GO:0003700 | inferred from biological aspect of ancestor with PANTHER:PTN001227002 DNA binding ; GO:0003677 | inferred from biological aspect of ancestor with PANTHER:PTN001227002" "regulation of transcription, DNA-templated ; GO:0006355 | inferred from biological aspect of ancestor with PANTHER:PTN001227002" nucleus ; GO:0005634 | inferred from biological aspect of ancestor with PANTHER:PTN001227002 "CG10269, D19A, d19a" "IPR012934:Zinc finger, AD-type, IPR013087:Zinc finger C2H2-type, IPR013083:Zinc finger, RING/FYVE/PHD-type" CG10269 27-Aug-18 DroID_v2018_08 "Drer\zgc:174268, Drer\znf770, Drer\znf1004, Drer\znf668, Drer\znf990, Drer\si:dkey-33c14.6, Drer\znf341, Drer\zgc:162948" Scer\PZF1 "Cele\eor-1, Cele\ZK546.5, Cele\Y55F3AM.14, Cele\Y37F4.6, Cele\Y48G8AL.10, Cele\hinf-1, Cele\hbl-1, Cele\sem-4" "Xtro\hic1, Xtro\znf668" "Mmus\Zfp672, Mmus\Plagl1, Mmus\Zfp341, Mmus\Zfp668" "Hsap\ZNF317, Hsap\ZNF555, Hsap\ZNF782, Hsap\ZNF284, Hsap\ZNF341, Hsap\ZNF221, Hsap\ZNF668, Hsap\ZNF43" viable DRSC11133 IEK -1.89875976 -2.851653906 -2.516288756 -4.184940303 0.494635396 1.650365893 FBgn0001048 fs(3)HO231 female sterile (3) HO231 http://flybase.org/reports/FBgn0001048 - gene - - - "fs(3)231A, fs(3)HO231" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0033221 CG12825 - http://flybase.org/reports/FBgn0033221 protein_coding_gene - - integral component of membrane ; GO:0016021 | inferred from sequence model "CG12825, dmCG12825" - CG12825 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0262436 mir-310 mir-310 stem loop http://flybase.org/reports/FBgn0262436 miRNA_gene - response to nicotine ; GO:0035094 | inferred from mutant phenotype segmentation ; GO:0035282 | inferred from mutant phenotype head involution ; GO:0008258 | inferred from mutant phenotype cellular response to nitric oxide ; GO:0071732 | inferred from direct assay compound eye morphogenesis ; GO:0001745 | inferred from mutant phenotype - "mir-310, miR-310, Dme-miR-310, CR42995, Mir-310, CR33614, dme-mir-310, miR310, mIR-310" - CR42995 27-Aug-18 DroID_v2018_08 - - - - - - "viable,visible,lethal - all die before end of larval stage,some die during larval stage,lethal,partially lethal - majority die" "wing hair,wing" FBgn0039505 CG5934 - http://flybase.org/reports/FBgn0039505 protein_coding_gene - sensory perception of pain ; GO:0019233 | inferred from mutant phenotype - CG5934 IPR019357:Predicted coiled-coil protein (DUF2205) CG5934 27-Aug-18 DroID_v2018_08 "Drer\scocb, Drer\scoca" - Cele\unc-69 Xtro\scoc Mmus\Scoc Hsap\SCOC viable FBgn0030592 CG9514 - http://flybase.org/reports/FBgn0030592 protein_coding_gene "oxidoreductase activity, acting on CH-OH group of donors ; GO:0016614 | inferred from electronic annotation with InterPro:IPR000172, InterPro:IPR007867 flavin adenine dinucleotide binding ; GO:0050660 | inferred from electronic annotation with InterPro:IPR000172 oxidoreductase activity ; GO:0016491 | inferred from sequence or structural similarity with Eo" "oxidation-reduction process ; GO:0055114 | inferred from electronic annotation with InterPro:IPR000172, InterPro:IPR007867, InterPro:IPR023753 ecdysteroid metabolic process ; GO:0045455 | inferred from sequence or structural similarity with Eo inferred from genomic context with Eo" - "CG9514, Dm GMCdelta1" "IPR000172:Glucose-methanol-choline oxidoreductase, N-terminal, IPR007867:Glucose-methanol-choline oxidoreductase, C-terminal, IPR023753:FAD/NAD(P)-binding domain" CG9514 27-Aug-18 DroID_v2018_08 Drer\chdh - Cele\C34C6.4 - Mmus\Chdh Hsap\CHDH viable DRSC30059 K 0.878152916 0.267693627 0.167029725 0.592564886 0.343996625 -1.700268826 FBgn0036640 nxf2 nuclear RNA export factor 2 http://flybase.org/reports/FBgn0036640 protein_coding_gene - poly(A)+ mRNA export from nucleus ; GO:0016973 | inferred from biological aspect of ancestor with PANTHER:PTN000070434 nucleoplasm ; GO:0005654 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay "NXF2, CG4118, nxf2" "IPR018222:Nuclear transport factor 2, eukaryote, IPR005637:TAP C-terminal (TAP-C) domain, IPR001611:Leucine-rich repeat, IPR032675:Leucine-rich repeat domain, L domain-like, IPR032710:NTF2-like domain, IPR030217:Nuclear RNA export factor, IPR009060:UBA-like" CG4118 27-Aug-18 DroID_v2018_08 "Drer\zgc:153681, Drer\nxf1" Scer\MEX67 "Cele\nxf-1, Cele\nxf-2" Xtro\nxf1 "Mmus\Nxf1, Mmus\Tmem223, Mmus\Nxf7, Mmus\Nxf2, Mmus\Nxf3" "Hsap\NXF1, Hsap\NXF2, Hsap\NXF3, Hsap\NXF2B, Hsap\NXF5" "female sterile,female fertile" DRSC10403 I -1.547157048 0.790849092 -0.046858054 0.276373273 -1.105280854 -0.112959855 FBgn0003479 spn-A spindle A http://flybase.org/reports/FBgn0003479 FBgn0011700 protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR020587, InterPro:IPR020588 single-stranded DNA binding ; GO:0003697 | inferred from biological aspect of ancestor with PANTHER:PTN001415033 protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q9W157 double-stranded DNA binding ; GO:0003690 | inferred from biological aspect of ancestor with PANTHER:PTN001415033 recombinase activity ; GO:0000150 | inferred from sequence or structural similarity with HGNC:9817 endodeoxyribonuclease activity ; GO:0004520 | contributes_to inferred from biological aspect of ancestor with PANTHER:PTN001415033 recombinase activity ; GO:0000150 | inferred from biological aspect of ancestor with PANTHER:PTN001415033 DNA-dependent ATPase activity ; GO:0008094 | inferred from biological aspect of ancestor with PANTHER:PTN001415033 four-way junction DNA binding ; GO:0000400 | inferred from biological aspect of ancestor with PANTHER:PTN001415033" "mitotic recombination-dependent replication fork processing ; GO:1990426 | inferred from electronic annotation with InterPro:IPR011941 oogenesis ; GO:0048477 | traceable author statement polarity specification of dorsal/ventral axis ; GO:0009951 | inferred from mutant phenotype oocyte fate determination ; GO:0030716 | inferred from mutant phenotype double-strand break repair via synthesis-dependent strand annealing ; GO:0045003 | inferred from mutant phenotype reciprocal meiotic recombination ; GO:0007131 | inferred from biological aspect of ancestor with PANTHER:PTN001489025 regulation of double-strand break repair via homologous recombination ; GO:0010569 | inferred from mutant phenotype DNA recombination ; GO:0006310 | inferred from sequence or structural similarity with HGNC:9817 polarity specification of anterior/posterior axis ; GO:0009949 | inferred from mutant phenotype intracellular mRNA localization ; GO:0008298 | traceable author statement karyosome formation ; GO:0030717 | inferred from mutant phenotype DNA repair ; GO:0006281 | inferred from sequence or structural similarity with HGNC:9817 germarium-derived oocyte fate determination ; GO:0007294 | inferred from genetic interaction with mus301 DNA recombinase assembly ; GO:0000730 | inferred from biological aspect of ancestor with PANTHER:PTN001415033 response to ionizing radiation ; GO:0010212 | inferred from biological aspect of ancestor with PANTHER:PTN001415033 mitotic recombination ; GO:0006312 | inferred from biological aspect of ancestor with PANTHER:PTN001415033 oogenesis ; GO:0048477 | inferred from mutant phenotype intracellular mRNA localization ; GO:0008298 | inferred from mutant phenotype chromosome organization involved in meiotic cell cycle ; GO:0070192 | inferred from biological aspect of ancestor with PANTHER:PTN001489025 DNA repair ; GO:0006281 | inferred from genetic interaction with Blm, mus81 female meiotic division ; GO:0007143 | inferred from mutant phenotype strand invasion ; GO:0042148 | inferred from biological aspect of ancestor with PANTHER:PTN001415033 double-strand break repair ; GO:0006302 | inferred from mutant phenotype response to caffeine ; GO:0031000 | inferred from genetic interaction with MAGE" condensed nuclear chromosome ; GO:0000794 | inferred from biological aspect of ancestor with PANTHER:PTN001489025 nucleoplasm ; GO:0005654 | inferred from biological aspect of ancestor with PANTHER:PTN001489025 "DmRad51, spnA, dmRAD51, Rad51, Dm Rad51, D37788, DmRAD51, RAD51, CG7948, DMR, Dmrad51, DMR/DroRAD51, RA51, Rad51dm, DMR1, spn-A, rad51, Spn-A, RA51_DROME, dmrad51, SpnA" "IPR003593:AAA+ ATPase domain, IPR010995:DNA repair Rad51/transcription factor NusA, alpha-helical, IPR011941:DNA recombination/repair protein Rad51, IPR013632:DNA recombination and repair protein Rad51-like, C-terminal, IPR016467:DNA recombination and repair protein, RecA-like, IPR020587:DNA recombination and repair protein RecA, monomer-monomer interface, IPR020588:DNA recombination and repair protein RecA-like, ATP-binding domain, IPR033925:Rad51/DMC1/RadA, IPR027417:P-loop containing nucleoside triphosphate hydrolase" CG7948 27-Aug-18 DroID_v2018_08 "Drer\rad51, Drer\rad51b, Drer\dmc1, Drer\rad51d" "Scer\DMC1, Scer\RAD51" Cele\rad-51 "Xtro\rad51, Xtro\rad51d" "Mmus\Dmc1, Mmus\Rad51, Mmus\Rad51d, Mmus\Rad51b" "Hsap\DMC1, Hsap\RAD51D, Hsap\RAD51, Hsap\RAD51B" "viable,lethal,maternal effect,semi-fertile,radiation sensitive,dominant,DNA repair defective,meiotic cell cycle defective,female,lethal - all die before end of pupal stage,some die during pupal stage" "dorsal appendage,germline clone,chorion | dorsal | germline clone,egg,presumptive oocyte,karyosome,chorion,maternal effect,synaptonemal complexX3F),chorion | dorsalX3F),dorsal,oocyte,nurse cell,egg chamber,synaptonemal complex,germline cyst" DRSC16812 K -0.18460639 0.050961495 -0.157866144 0.030878465 2.326013271 0.759214734 FBgn0040905 CG15578 - http://flybase.org/reports/FBgn0040905 protein_coding_gene - - - CG15578 - CG15578 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0010343 HIS-C Histone complex http://flybase.org/reports/FBgn0010343 - protein_coding_gene - - - "his, HIS-C, histone, His-C" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0024712 anon-57Co anon-57Co http://flybase.org/reports/FBgn0024712 - gene - - - anon-57Co - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0060778 l(3)S060711a lethal (3) S060711a http://flybase.org/reports/FBgn0060778 gene - - - "0607/11, l(3)S060711a" - - 27-Aug-18 DroID_v2018_08 - - - - - - "partially lethal - majority die,recessive,lethal" FBgn0267478 asRNA:CR45828 - http://flybase.org/reports/FBgn0267478 non_protein_coding_gene - - - CR45828 - CR45828 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0038750 CG4465 - http://flybase.org/reports/FBgn0038750 protein_coding_gene organic anion transmembrane transporter activity ; GO:0008514 | inferred from biological aspect of ancestor with PANTHER:PTN001936837 transmembrane transport ; GO:0055085 | inferred from electronic annotation with InterPro:IPR011701 integral component of plasma membrane ; GO:0005887 | inferred from biological aspect of ancestor with PANTHER:PTN001175408 CG4465 "IPR011701:Major facilitator superfamily, IPR020846:Major facilitator superfamily domain" CG4465 27-Aug-18 DroID_v2018_08 "Drer\oatx, Drer\LOC101884074, Drer\slc22a13, Drer\slc22a21, Drer\zgc:175176, Drer\slc22a5, Drer\slc22a4, Drer\slc22a6l, Drer\slc22a2, Drer\sv2, Drer\LOC100334012, Drer\slc22a7b.1, Drer\zmp:0000001102, Drer\slc22a7b.2, Drer\slc22a7b.3" "Scer\QDR1, Scer\YHK8, Scer\DTR1, Scer\TPO2, Scer\TPO1, Scer\FLR1, Scer\TPO3, Scer\QDR3, Scer\AQR1, Scer\QDR2" "Cele\T22F7.1, Cele\oct-2, Cele\K09E9.1" Xtro\slc22a6 "Mmus\Slc22a3, Mmus\Slc22a27, Mmus\Slc22a28, Mmus\Slc22a29, Mmus\Slc22a1, Mmus\Svop, Mmus\Slc22a7, Mmus\Slc22a4, Mmus\Slc22a2, Mmus\Slc22a16, Mmus\Slc22a23, Mmus\Slc22a30, Mmus\Slc22a14, Mmus\Slc22a26, Mmus\Sv2c, Mmus\Slc22a19, Mmus\Slc22a6, Mmus\Slc22a20, Mmus\Slc22a22, Mmus\Slc22a8" "Hsap\SLC22A7, Hsap\SV2C, Hsap\SV2B, Hsap\SLC22A12, Hsap\SLC22A3, Hsap\SLC22A1, Hsap\SLC22A11, Hsap\SVOP, Hsap\SLC22A2, Hsap\SLC22A6, Hsap\SLC22A25, Hsap\SLC22A9, Hsap\SLC22A10, Hsap\SLC22A24, Hsap\SLC22A23, Hsap\SLC22A8" "viable,fertile" DRSC15584 E -0.01569009 -0.207640764 -1.832399723 -0.003269499 0.456789135 0.528808937 FBgn0046645 anon-38D.21 anon-38D.21 http://flybase.org/reports/FBgn0046645 gene - - - "38D.21, anon-38D.21" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0263898 A44 - http://flybase.org/reports/FBgn0263898 gene - - - A44 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive,decreased cell number,somatic clone" "embryonic/larval brain,somatic clone" FBgn0065775 l(2)SH0454 lethal (2) SH0454 http://flybase.org/reports/FBgn0065775 gene - - - "l(2)SH0454, l(2)SH2 0454" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0082954 snoRNA:Psi28S-3571 snoRNA:Psi28S-3571 http://flybase.org/reports/FBgn0082954 snoRNA_gene - - - "snoRNA:Psi28S-3571, psi28s-3571, Psi 28S-3571, CR34611, chr3R:1423362..1423500" - CR34611 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0053194 CheA29a Chemosensory protein A 29a http://flybase.org/reports/FBgn0053194 protein_coding_gene molecular_function ; GO:0003674 | no biological data available sensory perception of chemical stimulus ; GO:0007606 | inferred from expression pattern detection of pheromone ; GO:0043695 | inferred from expression pattern extracellular region ; GO:0005576 | inferred from sequence model "CG33194, CheA29a" - CG33194 27-Aug-18 DroID_v2018_08 - - - - - - adult stage | male " prothoracic tarsal segment

, prothoracic tarsal segment 3

, prothoracic tarsal segment 2

, head

, prothoracic tarsal segment 1

, prothoracic tarsal segment 4

" "viable,fertile" DRSC21486 K -0.328872632 0.196732457 0.688702037 0.631062025 -1.575566016 -1.801877171 FBgn0002308 l(3)84Ff lethal (3) 84Ff http://flybase.org/reports/FBgn0002308 - gene - - - "l(3)EfK3, l(3)84Ff" - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0039333 CG11917 - http://flybase.org/reports/FBgn0039333 protein_coding_gene - - - CG11917 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0060604 l(3)S091104 lethal (3) S091104 http://flybase.org/reports/FBgn0060604 gene - - - "0911/04, l(3)S091104" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0065127 l(3)SH138 lethal (3) SH138 http://flybase.org/reports/FBgn0065127 gene - - - "l(3)SH138, l(2)SH3 138" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0001024 fs(3)A15 female sterile (3) A15 http://flybase.org/reports/FBgn0001024 - gene - - - fs(3)A15 - - 27-Aug-18 DroID_v2018_08 - - - - - - "female sterile,recessive,mitotic cell cycle defective" "female reproductive system,spindle" FBgn0265646 lncRNA:CR44453 - http://flybase.org/reports/FBgn0265646 non_protein_coding_gene - - - "lincRNA.293, CR44453" - CR44453 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0066084 RpL41 Ribosomal protein L41 http://flybase.org/reports/FBgn0066084 protein_coding_gene structural constituent of ribosome ; GO:0003735 | traceable author statement structural constituent of ribosome ; GO:0003735 | inferred from sequence or structural similarity with SGD:S000002343 structural constituent of ribosome ; GO:0003735 | non-traceable author statement translation ; GO:0006412 | non-traceable author statement cytoplasmic translation ; GO:0002181 | traceable author statement cytoplasmic translation ; GO:0002181 | inferred from sequence or structural similarity with SGD:S000002343 nucleoplasm ; GO:0005654 | inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay nucleolus ; GO:0005730 | inferred from direct assay cytosolic large ribosomal subunit ; GO:0022625 | non-traceable author statement cytosol ; GO:0005829 | inferred from direct assay nuclear chromosome ; GO:0000228 | inferred from direct assay cytosolic large ribosomal subunit ; GO:0022625 | traceable author statement cytosolic large ribosomal subunit ; GO:0022625 | inferred from sequence or structural similarity with SGD:S000002343 "pncr005:2R, CG30425, L41, BcDNA:RE63504, BEST:LP07070, BcDNA:LP07070, CR30425, RpL41, Rpl41" IPR007836:Ribosomal protein L41 CG30425 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0040650 CG15456 - http://flybase.org/reports/FBgn0040650 protein_coding_gene - - - CG15456 "IPR011893:Selenoprotein, Rdx type, IPR012336:Thioredoxin-like fold" CG15456 27-Aug-18 DroID_v2018_08 "Drer\sepw2a, Drer\sepw2b, Drer\sepw1" - Cele\F28H7.4 Xtro\mien1 "Mmus\Mien1, Mmus\Selenow" "Hsap\MIEN1, Hsap\SELENOW" viable FBgn0266274 T:SS-trypsin Signal sequence of trypsin http://flybase.org/reports/FBgn0266274 engineered_foreign_region - - - T:SS-trypsin - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0036440 CG17177 - http://flybase.org/reports/FBgn0036440 protein_coding_gene - - - CG17177 - CG17177 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0060411 l(3)S130204b lethal (3) S130204b http://flybase.org/reports/FBgn0060411 gene - - - "1302/04, l(3)S130204b" - - 27-Aug-18 DroID_v2018_08 - - - - - - "partially lethal - majority die,recessive" FBgn0003341 scrp scarp http://flybase.org/reports/FBgn0003341 - gene - - - scrp - - 27-Aug-18 DroID_v2018_08 - - - - - - "eye,heat sensitive" FBgn0267182 lncRNA:CR45622 - http://flybase.org/reports/FBgn0267182 non_protein_coding_gene - - - CR45622 - CR45622 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0015449 l(1)9Fi lethal (1) 9Fi http://flybase.org/reports/FBgn0015449 - gene - - - l(1)9Fi - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive,partially lethal - majority die" FBgn0034422 CG7137 - http://flybase.org/reports/FBgn0034422 protein_coding_gene methylated histone binding ; GO:0035064 | inferred from biological aspect of ancestor with PANTHER:PTN000980278 methylated histone binding ; GO:0035064 | inferred from sequence or structural similarity with UniProtKB:O43159 S-adenosylmethionine-dependent methyltransferase activity ; GO:0008757 | inferred from biological aspect of ancestor with PANTHER:PTN000300315 chromatin silencing at rDNA ; GO:0000183 | inferred from sequence or structural similarity with UniProtKB:O43159 cellular response to glucose starvation ; GO:0042149 | inferred from biological aspect of ancestor with PANTHER:PTN000980278 chromatin silencing at rDNA ; GO:0000183 | inferred from biological aspect of ancestor with PANTHER:PTN000980278 regulation of transcription by glucose ; GO:0046015 | inferred from biological aspect of ancestor with PANTHER:PTN000980278 chromatin silencing complex ; GO:0005677 | inferred from biological aspect of ancestor with PANTHER:PTN000980278 nucleolus ; GO:0005730 | inferred from biological aspect of ancestor with PANTHER:PTN000300315 rDNA heterochromatin ; GO:0033553 | inferred from biological aspect of ancestor with PANTHER:PTN000980278 nucleolus ; GO:0005730 | inferred from sequence or structural similarity with UniProtKB:O43159 rDNA heterochromatin ; GO:0033553 | inferred from sequence or structural similarity with UniProtKB:O43159 chromatin silencing complex ; GO:0005677 | inferred from sequence or structural similarity with UniProtKB:O43159 CG7137 "IPR007823:Ribosomal RNA processing protein 8, IPR029063:S-adenosyl-L-methionine-dependent methyltransferase" CG7137 27-Aug-18 DroID_v2018_08 Drer\si:ch211-149e23.3 Scer\RRP8 Cele\T07A9.8 - Mmus\Rrp8 Hsap\RRP8 "viable,visible" trichogen cell FBgn0037356 CG12170 - http://flybase.org/reports/FBgn0037356 protein_coding_gene "transferase activity, transferring acyl groups other than amino-acyl groups ; GO:0016747 | inferred from electronic annotation with InterPro:IPR017568" fatty acid biosynthetic process ; GO:0006633 | inferred from electronic annotation with InterPro:IPR017568 - "anon-WO0118547.367, CG12170" "IPR018201:Beta-ketoacyl synthase, active site, IPR014030:Beta-ketoacyl synthase, N-terminal, IPR014031:Beta-ketoacyl synthase, C-terminal, IPR016039:Thiolase-like, IPR017568:3-oxoacyl-[acyl-carrier-protein] synthase 2, IPR020841:Polyketide synthase, beta-ketoacyl synthase domain" CG12170 27-Aug-18 DroID_v2018_08 Drer\oxsm Scer\CEM1 Cele\F10G8.9 Xtro\oxsm Mmus\Oxsm Hsap\OXSM viable FBgn0264898 lncRNA:CR44089 - http://flybase.org/reports/FBgn0264898 non_protein_coding_gene - - - CR44089 - CR44089 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0033734 CG8520 - http://flybase.org/reports/FBgn0033734 protein_coding_gene ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR005654 sensory perception of pain ; GO:0019233 | inferred from mutant phenotype - "CG8520, FBgn 33734" "IPR005654:ATPase, AFG1-like, IPR027417:P-loop containing nucleoside triphosphate hydrolase" CG8520 27-Aug-18 DroID_v2018_08 "Drer\lace1b, Drer\lace1a" Scer\AFG1 Cele\C30F12.2 Xtro\lace1 Mmus\Lace1 Hsap\LACE1 "viable,fertile" FBgn0053470 CG33470 - http://flybase.org/reports/FBgn0053470 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG33470 - CG33470 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0033861 CG12464 - http://flybase.org/reports/FBgn0033861 protein_coding_gene - - mitochondrial respiratory chain complex I ; GO:0005747 | inferred from electronic annotation with InterPro:IPR026193 CG12464 IPR026193:NADH-ubiquinone oxidoreductase flavoprotein 3 CG12464 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0025576 M285 M285 http://flybase.org/reports/FBgn0025576 - gene molecular_function ; GO:0003674 | no biological data available Notch signaling pathway ; GO:0007219 | inferred from genetic interaction with N nervous system development ; GO:0007399 | inferred from mutant phenotype sensory organ development ; GO:0007423 | inferred from genetic interaction with N imaginal disc-derived wing margin morphogenesis ; GO:0008587 | inferred from genetic interaction with N cellular_component ; GO:0005575 | no biological data available M285 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of embryonic stage,recessive,some die during embryonic stage" FBgn0084025 CG41464 - http://flybase.org/reports/FBgn0084025 protein_coding_gene - - - CG41464 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0044506 BS\RTase BS element RTase http://flybase.org/reports/FBgn0044506 transposable_element_gene - - cellular_component ; GO:0005575 | no biological data available "RT, Bs ORF2, BS\RTase, RTase" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0036838 CG3808 - http://flybase.org/reports/FBgn0036838 protein_coding_gene nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR000504 RNA methyltransferase activity ; GO:0008173 | inferred from electronic annotation with InterPro:IPR010280 mRNA binding ; GO:0003729 | inferred from sequence or structural similarity RNA processing ; GO:0006396 | inferred from electronic annotation with InterPro:IPR010280 - "cg3808, CG3808" "IPR000504:RNA recognition motif domain, IPR030391:RNA methyltransferase TrmA, conserved site, IPR030390:RNA methyltransferase TrmA, active site, IPR010280:(Uracil-5)-methyltransferase family, IPR034262:TRMT2A, RNA recognition motif, IPR029063:S-adenosyl-L-methionine-dependent methyltransferase" CG3808 27-Aug-18 DroID_v2018_08 "Drer\trmt2b, Drer\trmt2a" Scer\TRM2 Cele\H24K24.4 "Xtro\trmt2b, Xtro\trmt2a" "Mmus\Trmt2a, Mmus\Trmt2b" "Hsap\TRMT2A, Hsap\TRMT2B" "viable,fertile" FBgn0058257 CR40257 - http://flybase.org/reports/FBgn0058257 non_protein_coding_gene - - - CR40257 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0065817 l(2)SH0377 lethal (2) SH0377 http://flybase.org/reports/FBgn0065817 gene - - - "l(2)SH0377, l(2)SH2 0377" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0052791 DIP-alpha Dpr-interacting protein alpha http://flybase.org/reports/FBgn0052791 protein_coding_gene - synapse organization ; GO:0050808 | inferred from expression pattern neuron projection membrane ; GO:0032589 | inferred from direct assay integral component of plasma membrane ; GO:0005887 | inferred from sequence model "CG32791, CG13020, CG13019, 32791, DIP-alpha" "IPR003598:Immunoglobulin subtype 2, IPR003599:Immunoglobulin subtype, IPR007110:Immunoglobulin-like domain, IPR013783:Immunoglobulin-like fold, IPR013098:Immunoglobulin I-set" CG32791 27-Aug-18 DroID_v2018_08 "Drer\mxra8b, Drer\zgc:110372, Drer\lsamp, Drer\si:zfos-1011f11.1, Drer\gpa33, Drer\vsig8a, Drer\si:dkey-65b12.12, Drer\mxra8a, Drer\cxcr3.1, Drer\si:ch211-9d9.7, Drer\si:ch211-215e19.3, Drer\f11r.1, Drer\jam3b, Drer\vsig8b, Drer\f11r.2, Drer\pigrl4.2, Drer\ntm, Drer\jam3a, Drer\jam2a, Drer\LOC100151468, Drer\si:dkey-250k15.10, Drer\negr1, Drer\opcml, Drer\igsf11, Drer\cxadr, Drer\jam2b, Drer\esamb, Drer\esama, Drer\zgc:153073" - "Cele\rig-5, Cele\zig-4" "Xtro\ntm, Xtro\negr1, Xtro\lsamp" "Mmus\Esam, Mmus\Vsig8, Mmus\Igsf11, Mmus\Iglon5, Mmus\Jam3, Mmus\Vsig2, Mmus\Vsir, Mmus\Opcml, Mmus\F11r, Mmus\Clmp, Mmus\Negr1, Mmus\Ntm, Mmus\Mxra8, Mmus\Gm1123, Mmus\Hepacam2, Mmus\Jam2, Mmus\Vsig1, Mmus\Igsf5, Mmus\Lsamp, Mmus\Gpa33, Mmus\Cxadr" "Hsap\GPA33, Hsap\CLMP, Hsap\NEGR1, Hsap\IGSF11, Hsap\JAM3, Hsap\IGLON5, Hsap\F11R, Hsap\CXADR, Hsap\MXRA8, Hsap\VSIG1, Hsap\VSIG8, Hsap\OPCML, Hsap\NTM, Hsap\C1orf204, Hsap\LSAMP, Hsap\VSIG2, Hsap\JAM2, Hsap\ESAM, Hsap\C10orf54, Hsap\IGSF5" "visible,partially lethal - majority die,some die during pupal stage,lethal" "chaeta,supernumerary,trichogen cell" FBgn0060840 l(3)S049508b lethal (3) S049508b http://flybase.org/reports/FBgn0060840 gene - - - "0495/08, l(3)S049508b" - - 27-Aug-18 DroID_v2018_08 - - - - - - "partially lethal - majority die,recessive" FBgn0050371 CG30371 - http://flybase.org/reports/FBgn0050371 protein_coding_gene "serine-type endopeptidase activity ; GO:0004252 | inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114 serine-type endopeptidase activity ; GO:0004252 | inferred from sequence model" "proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114 proteolysis ; GO:0006508 | inferred from sequence model" - "SP80, CG2280, CG30371" "IPR000859:CUB domain, IPR001254:Serine proteases, trypsin domain, IPR001314:Peptidase S1A, chymotrypsin family, IPR009003:Peptidase S1, PA clan, IPR018114:Serine proteases, trypsin family, histidine active site" CG30371 27-Aug-18 DroID_v2018_08 Drer\f10 - "Cele\F25E5.3, Cele\svh-1, Cele\try-5, Cele\try-9, Cele\T21E12.3" - "Mmus\Tmprss7, Mmus\Tmprss6, Mmus\St14" "Hsap\TMPRSS6, Hsap\TMPRSS7, Hsap\F10, Hsap\ST14" "viable,visible" "antenna,leg,ectopic" FBgn0025472 qkr58E-5 quaking related 58E-5 http://flybase.org/reports/FBgn0025472 - gene - - - "qrk58E-5, qkr58E-5" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0267739 asRNA:CR46070 - http://flybase.org/reports/FBgn0267739 non_protein_coding_gene - - - "CR46070, Mgn3671" - CR46070 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0051754 His-Psi:CR31754 His-Psi:CR31754 http://flybase.org/reports/FBgn0051754 pseudogene_attribute - - - "CR31754, His-Psi:CR31754" - CR31754 27-Aug-18 DroID_v2018_08 - - - - - - DRSC22051 IE 1.765175641 -3.517577589 -1.389565049 -5.118172072 0.626504918 0.964516608 FBgn0263841 CG43702 - http://flybase.org/reports/FBgn0263841 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG43702 - CG43702 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0029895 CG14441 - http://flybase.org/reports/FBgn0029895 protein_coding_gene nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR013087 zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR012934 - nucleus ; GO:0005634 | inferred from electronic annotation with InterPro:IPR012934 CG14441 "IPR012934:Zinc finger, AD-type, IPR019400:Peptidase C65, otubain, IPR013087:Zinc finger C2H2-type, IPR015943:WD40/YVTN repeat-like-containing domain" CG14441 27-Aug-18 DroID_v2018_08 Drer\srcap Scer\SWR1 Cele\ssl-1 - Mmus\Srcap Hsap\SRCAP "viable,fertile" FBgn0037005 CG5078 - http://flybase.org/reports/FBgn0037005 protein_coding_gene transporter activity ; GO:0005215 | inferred from biological aspect of ancestor with PANTHER:PTN001921112 transmembrane transport ; GO:0055085 | inferred from biological aspect of ancestor with PANTHER:PTN001921112 "integral component of membrane ; GO:0016021 | inferred from electronic annotation with InterPro:IPR005829, InterPro:IPR011701" CG5078 "IPR001958:Tetracycline resistance protein TetA/multidrug resistance protein MdtG, IPR005829:Sugar transporter, conserved site, IPR011701:Major facilitator superfamily, IPR020846:Major facilitator superfamily domain" CG5078 27-Aug-18 DroID_v2018_08 "Drer\si:dkey-5g14.1, Drer\hiat1b, Drer\si:ch211-262i1.4, Drer\hiat1a, Drer\LOC557306, Drer\zgc:174356, Drer\slc46a3, Drer\si:ch211-87m7.2" Scer\YJL163C "Cele\T25D3.4, Cele\Y71G12B.25" "Xtro\mfsd14a, Xtro\mfsd14b" "Mmus\Slc46a3, Mmus\Mfsd14b, Mmus\Slc46a1, Mmus\Mfsd14a" "Hsap\MFSD14A, Hsap\MFSD14B, Hsap\SLC46A1, Hsap\SLC46A3" "visible,partially lethal - majority die,some die during pupal stage" trichogen cell FBgn0000683 flrdF flight reduced F http://flybase.org/reports/FBgn0000683 - gene molecular_function ; GO:0003674 | no biological data available flight behavior ; GO:0007629 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available flrdF - - 27-Aug-18 DroID_v2018_08 - - - - - - "jumping defective,flightless" FBgn0065115 l(3)SH160 lethal (3) SH160 http://flybase.org/reports/FBgn0065115 gene - - - "l(3)SH160, l(2)SH3 160" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0065493 l(2)SH1228 lethal (2) SH1228 http://flybase.org/reports/FBgn0065493 gene - - - "l(2)SH1228, l(2)SH2 1228" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0267802 lncRNA:CR46127 - http://flybase.org/reports/FBgn0267802 non_protein_coding_gene - - - CR46127 - CR46127 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0029789 PGAP1 Post-GPI attachment to proteins 1 http://flybase.org/reports/FBgn0029789 protein_coding_gene phosphoric ester hydrolase activity ; GO:0042578 | inferred from sequence or structural similarity with UniProtKB:Q765A7 nuclease activity ; GO:0004518 | inferred from sequence or structural similarity with UniProtKB:Q765A7 myo-inositol transport ; GO:0015798 | inferred from sequence or structural similarity with UniProtKB:Q765A7 endoplasmic reticulum ; GO:0005783 | inferred from sequence or structural similarity with UniProtKB:Q765A7 "CG3160, PGAP1" "IPR012908:GPI inositol-deacylase PGAP1-like, IPR029058:Alpha/Beta hydrolase fold" CG3160 27-Aug-18 DroID_v2018_08 Drer\pgap1 Scer\BST1 "Cele\her-1, Cele\T19B10.8, Cele\lips-9, Cele\nhr-49" - "Mmus\Pgap1, Mmus\Epas1" "Hsap\PGAP1, Hsap\C2orf66" "viable,body color defective" mesothoracic tergum FBgn0031187 Usp2 Ubiquitin specific protease 2 http://flybase.org/reports/FBgn0031187 protein_coding_gene Lys48-specific deubiquitinase activity ; GO:1990380 | inferred from direct assay protein binding ; GO:0005515 | inferred from physical interaction with imd thiol-dependent ubiquitin-specific protease activity ; GO:0004843 | inferred from sequence or structural similarity with HGNC:12631 proteasome binding ; GO:0070628 | inferred from physical interaction with Rpt6 ubiquitin-dependent protein catabolic process ; GO:0006511 | inferred from electronic annotation with InterPro:IPR018200 negative regulation of innate immune response ; GO:0045824 | inferred from mutant phenotype negative regulation of defense response to bacterium ; GO:1900425 | inferred from mutant phenotype protein deubiquitination ; GO:0016579 | inferred from mutant phenotype protein K48-linked deubiquitination ; GO:0071108 | inferred from direct assay protein deubiquitination ; GO:0016579 | inferred from sequence or structural similarity with HGNC:12631 negative regulation of antimicrobial peptide production ; GO:0002785 | inferred from mutant phenotype positive regulation of proteasomal protein catabolic process ; GO:1901800 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available "CG14619, Usp2, Q9VR54, dUsp2" "IPR001394:Peptidase C19, ubiquitin carboxyl-terminal hydrolase, IPR018200:Ubiquitin specific protease, conserved site, IPR028889:Ubiquitin specific protease domain" CG14619 27-Aug-18 DroID_v2018_08 "Drer\usp4, Drer\usp43b, Drer\usp8, Drer\usp2b, Drer\usp21, Drer\usp32, Drer\usp11, Drer\usp2a" "Scer\UBP5, Scer\UBP7, Scer\UBP11, Scer\DOA4, Scer\UBP12, Scer\UBP8" "Cele\F07A11.4, Cele\usp-3, Cele\H34C03.2, Cele\usp-33, Cele\cyk-3, Cele\usp-50" "Xtro\usp21, Xtro\usp15, Xtro\usp8, Xtro\usp37, Xtro\usp2" "Mmus\Usp15, Mmus\Usp4, Mmus\Usp26, Mmus\Usp27x, Mmus\Usp43, Mmus\Usp22, Mmus\Usp2, Mmus\Usp11, Mmus\Usp8, Mmus\Usp3, Mmus\Usp32, Mmus\Usp37, Mmus\Usp29, Mmus\Usp21, Mmus\Usp50" "Hsap\USP4, Hsap\USP50, Hsap\USP37, Hsap\USP11, Hsap\USP3, Hsap\USP2, Hsap\USP21, Hsap\USP10, Hsap\USP8, Hsap\USP27X, Hsap\USP22, Hsap\USP43, Hsap\USP29, Hsap\USP32, Hsap\USP26" "lethal,recessive,body color defective,partially lethal - majority die,some die during pupal stage,lethal - all die before end of pupal stage,viable,locomotor behavior defective,short lived" "mesothoracic tergum,prepupa" FBgn0000365 cpw canopy wing http://flybase.org/reports/FBgn0000365 - gene - - - cpw - - 27-Aug-18 DroID_v2018_08 - - - - - - "male sterile,partially lethal - majority die,visible,recessive,viable,male,reduced" "wing,wing vein,eye,ocellar bristle,thorax,adult thorax,macrochaeta,microchaeta,head bristle" FBgn0031268 cold coiled http://flybase.org/reports/FBgn0031268 protein_coding_gene - "wound healing ; GO:0042060 | inferred from mutant phenotype maintenance of permeability of blood-brain barrier ; GO:0035633 | inferred from direct assay establishment of blood-brain barrier ; GO:0060856 | inferred from direct assay septate junction assembly ; GO:0019991 | inferred from direct assay septate junction assembly ; GO:0019991 | inferred from mutant phenotype regulation of tube size, open tracheal system ; GO:0035151 | inferred from mutant phenotype" cytoplasm ; GO:0005737 | inferred from direct assay "CG2813, cold, cg2813, leaky4" - CG2813 27-Aug-18 DroID_v2018_08 "Drer\si:ch211-134a4.1, Drer\si:ch211-134a4.5, Drer\negaly6, Drer\LOC100535423, Drer\si:ch211-134a4.2, Drer\si:dkeyp-80c12.8, Drer\si:dkey-102g19.3" - - - "Mmus\Pinlyp, Mmus\2210407C18Rik, Mmus\1810065E05Rik, Mmus\4930504O13Rik, Mmus\Gm12253, Mmus\Lypd8" "Hsap\PINLYP, Hsap\LYPD8" "lethal,lethal - all die before end of embryonic stage,some die during embryonic stage,visible,partially lethal - majority die,some die during pupal stage" "embryonic/larval dorsal trunk,presumptive embryonic/larval tracheal system,subperineurial glial cell,trichogen cell" FBgn0000333 cmd carminoid http://flybase.org/reports/FBgn0000333 - gene - - - cmd - - 27-Aug-18 DroID_v2018_08 - - - - - - eye color defective pigment cell FBgn0025870 C141 C141 http://flybase.org/reports/FBgn0025870 - gene - adult walking behavior ; GO:0007628 | traceable author statement - C141 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0069929 CG41122 - http://flybase.org/reports/FBgn0069929 protein_coding_gene - - - CG41122 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0014932 anon-87Ea anon-87Ea http://flybase.org/reports/FBgn0014932 - gene - - - "A, anon-87Ea" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0003139 PpV Protein phosphatase V http://flybase.org/reports/FBgn0003139 - protein_coding_gene "hydrolase activity ; GO:0016787 | inferred from electronic annotation with InterPro:IPR004843, InterPro:IPR006186 protein serine/threonine phosphatase activity ; GO:0004722 | non-traceable author statement protein serine/threonine phosphatase activity ; GO:0004722 | inferred from sequence model" mitotic cell cycle ; GO:0000278 | inferred from mutant phenotype protein dephosphorylation ; GO:0006470 | non-traceable author statement G1/S transition of mitotic cell cycle ; GO:0000082 | inferred from genetic interaction with SGD:S000002205 protein dephosphorylation ; GO:0006470 | inferred from sequence model cytoplasm ; GO:0005737 | inferred from direct assay "DmPpV-6A, CG12217, PPV, PPPV6A, PPV 6A, PpV, Ppv, dPP6, PP6, PpV[[C]]" "IPR004843:Calcineurin-like phosphoesterase domain, ApaH type, IPR006186:Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase, IPR029052:Metallo-dependent phosphatase-like" CG12217 27-Aug-18 DroID_v2018_08 "Drer\zgc:56064, Drer\ppp4ca, Drer\ppp6c, Drer\ppp2ca, Drer\ppp4cb, Drer\ppp2cb" "Scer\YNL217W, Scer\SIT4, Scer\PPH22, Scer\PPH3, Scer\PPH21" "Cele\pph-6, Cele\pph-4.1, Cele\pph-4.2" "Xtro\ppp4c, Xtro\ppp6c, Xtro\ppp2ca, Xtro\ppp2cb" "Mmus\Ppp2ca, Mmus\Ppp4c, Mmus\Ppp6c, Mmus\Ppp2cb" "Hsap\PPP2CA, Hsap\PPP6C, Hsap\PPP2CB" " embryonic stage | stage 5 , embryonic stage -- adult stage , embryonic stage | stage 4 " organism

" embryonic stage | stage 4 , embryonic stage | stage 5 " organism

"visible,viable" "wing,trichogen cell" FBgn0052745 CR32745 - http://flybase.org/reports/FBgn0052745 pseudogene_attribute - - - "CG32745, CR32745" - CR32745 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0037513 pyd3 pyd3 http://flybase.org/reports/FBgn0037513 protein_coding_gene beta-ureidopropionase activity ; GO:0003837 | inferred from direct assay 'de novo' pyrimidine nucleobase biosynthetic process ; GO:0006207 | inferred from genetic interaction with r pyrimidine nucleobase catabolic process ; GO:0006208 | inferred by curator from GO:0003837 - "CG3027, pyd3, betaASase, betaAS" IPR003010:Carbon-nitrogen hydrolase CG3027 27-Aug-18 DroID_v2018_08 Drer\upb1 - Cele\upb-1 Xtro\upb1 Mmus\Upb1 Hsap\UPB1 "viable,fertile" FBgn0263133 mEFG1 mitochondrial translation elongation factor G 1 http://flybase.org/reports/FBgn0263133 protein_coding_gene "GTP binding ; GO:0005525 | inferred from electronic annotation with InterPro:IPR000795, InterPro:IPR004161, InterPro:IPR004540, InterPro:IPR005225, InterPro:IPR005517 translation elongation factor activity ; GO:0003746 | inferred from biological aspect of ancestor with PANTHER:PTN002462392 GTPase activity ; GO:0003924 | inferred from sequence or structural similarity with UniProtKB:Q96RP9 translation elongation factor activity ; GO:0003746 | inferred from sequence or structural similarity with UniProtKB:Q96RP9 GTPase activity ; GO:0003924 | inferred from biological aspect of ancestor with PANTHER:PTN002462392" mitochondrial translational elongation ; GO:0070125 | inferred from sequence or structural similarity with UniProtKB:Q96RP9 mitochondrial translational elongation ; GO:0070125 | inferred from biological aspect of ancestor with PANTHER:PTN000563009 nucleus ; GO:0005634 | inferred from direct assay mitochondrion ; GO:0005739 | inferred from direct assay "CG4567, dEF-G1, GFM1, G, l(2)27Ea, B, l(2)27Cb, ico, mEFG1" "IPR027417:P-loop containing nucleoside triphosphate hydrolase, IPR014721:Ribosomal protein S5 domain 2-type fold, subgroup, IPR009022:Elongation factor G, III-V domain, IPR009000:Translation protein, beta-barrel domain, IPR005517:Translation elongation factor EFG/EF2, domain IV, IPR005225:Small GTP-binding protein domain, IPR004540:Translation elongation factor EFG/EF2, IPR004161:Translation elongation factor EFTu-like, domain 2, IPR000795:Transcription factor, GTP-binding domain, IPR000640:Translation elongation factor EFG, V domain, IPR020568:Ribosomal protein S5 domain 2-type fold, IPR031157:Tr-type G domain, conserved site" CG4567 27-Aug-18 DroID_v2018_08 "Drer\gfm1, Drer\gfm2" "Scer\MEF1, Scer\MEF2" "Cele\gfm-1, Cele\Y119D3B.14, Cele\F58G1.8" "Xtro\gfm1, Xtro\gfm2" "Mmus\Gfm2, Mmus\Gfm1" "Hsap\GFM1, Hsap\GFM2" FBgn0050108 CG30108 - http://flybase.org/reports/FBgn0050108 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available mitochondrial intermembrane space ; GO:0005758 | inferred from biological aspect of ancestor with PANTHER:PTN000481815 CG30108 IPR007918:Mitochondrial distribution/morphology family 35/apoptosis CG30108 27-Aug-18 DroID_v2018_08 Drer\triap1 Scer\MDM35 Cele\T09A5.7 Xtro\triap1 Mmus\Triap1 Hsap\TRIAP1 "viable,fertile" FBgn0262114 RanBPM Ran-binding protein M http://flybase.org/reports/FBgn0262114 protein_coding_gene Ran GTPase binding ; GO:0008536 | inferred from sequence or structural similarity with HGNC:13727 larval feeding behavior ; GO:0030536 | inferred from mutant phenotype germ-line stem-cell niche homeostasis ; GO:0060250 | inferred from mutant phenotype dorsal appendage formation ; GO:0046843 | inferred from mutant phenotype ovarian follicle cell-cell adhesion ; GO:0007299 | inferred from mutant phenotype JAK-STAT cascade ; GO:0007259 | inferred from mutant phenotype cytoskeleton organization ; GO:0007010 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay membrane ; GO:0016020 | inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay "RanBPM, CG42236, CG11763, l(2)k05201" "IPR024964:CTLH/CRA C-terminal to LisH motif domain, IPR013320:Concanavalin A-like lectin/glucanase domain, IPR001870:B30.2/SPRY domain, IPR006594:LIS1 homology motif, IPR013144:CRA domain, IPR006595:CTLH, C-terminal LisH motif, IPR003877:SPRY domain" CG42236 27-Aug-18 DroID_v2018_08 "Drer\ranbp10, Drer\spryd3, Drer\ranbp9" "Scer\SSH4, Scer\EAR1, Scer\VID30" "Cele\tag-304, Cele\Y54E5A.7" "Xtro\ranbp9, Xtro\spryd3" "Mmus\Ranbp9, Mmus\Ranbp10, Mmus\Spryd3" "Hsap\SPRYD3, Hsap\RANBP10, Hsap\RANBP9" FBgn0026165 schmalspur schmalspur http://flybase.org/reports/FBgn0026165 - gene molecular_function ; GO:0003674 | no biological data available central nervous system development ; GO:0007417 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available "sur, schmalspur" - - 27-Aug-18 DroID_v2018_08 - - - - - - "commissure,midline glial cell,presumptive embryonic/larval central nervous system,longitudinal connective,presumptive embryonic/larval peripheral nervous system,sensory neuron,motor neuron" FBgn0266651 lncRNA:CR45158 - http://flybase.org/reports/FBgn0266651 non_protein_coding_gene - - - CR45158 - CR45158 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0266220 lncRNA:CR44915 - http://flybase.org/reports/FBgn0266220 non_protein_coding_gene - - - CR44915 - CR44915 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0025107 Brg-P9 Brg-P9 http://flybase.org/reports/FBgn0025107 - gene - - - Brg-P9 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0069334 UY4766 UY4766 http://flybase.org/reports/FBgn0069334 gene - - - UY4766 - - 27-Aug-18 DroID_v2018_08 - - - - - - neuroanatomy defective "mushroom body & axon7B,Kenyon cell,mushroom body gamma-lobe" FBgn0262372 mir-3 mir-3 stem loop http://flybase.org/reports/FBgn0262372 miRNA_gene - - - "mir-3, 3, miR-3, CR42890, CR33037" - CR42890 27-Aug-18 DroID_v2018_08 - - - - - - embryonic stage | 0-12 hr "viable,lethal,lethal - all die before end of pupal stage,some die during pupal stage" wing FBgn0039558 BCAS2 BCAS2 http://flybase.org/reports/FBgn0039558 protein_coding_gene molecular_function ; GO:0003674 | no biological data available "mRNA processing ; GO:0006397 | inferred from mutant phenotype mRNA splicing, via spliceosome ; GO:0000398 | inferred by curator from GO:0071011,GO:0071013" Prp19 complex ; GO:0000974 | inferred from direct assay catalytic step 2 spliceosome ; GO:0071013 | inferred from direct assay precatalytic spliceosome ; GO:0071011 | inferred from direct assay "CG4980, BCAS2, dBCAS2" IPR008409:Pre-mRNA-splicing factor SPF27 CG4980 27-Aug-18 DroID_v2018_08 Drer\bcas2 - Cele\T12A2.7 Xtro\bcas2 Mmus\Bcas2 Hsap\BCAS2 "viable,visible,body color defective,increased cell death,lethal" "trichogen cell,mesothoracic tergum,wing,scutellum,chaeta,wing disc,posterior compartment" FBgn0058165 CG40165 - http://flybase.org/reports/FBgn0058165 protein_coding_gene - - - CG40165 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0259345 EP-990 - http://flybase.org/reports/FBgn0259345 gene - - - EP-990 - - 27-Aug-18 DroID_v2018_08 - - - - - - visible "wing vein,wing margin,chaeta,ectopic" FBgn0044389 Scim5 Sensitized chromosome inheritance modifier 5 http://flybase.org/reports/FBgn0044389 gene - female meiosis chromosome segregation ; GO:0016321 | inferred from mutant phenotype - Scim5 - - 27-Aug-18 DroID_v2018_08 - - - - - - "meiotic cell cycle defective,dominant" FBgn0022344 CG10340 - http://flybase.org/reports/FBgn0022344 - protein_coding_gene - mitochondrial proton-transporting ATP synthase complex assembly ; GO:0033615 | inferred from biological aspect of ancestor with PANTHER:PTN000319591 mitochondrion ; GO:0005739 | inferred from biological aspect of ancestor with PANTHER:PTN000319591 "anon2A5, anon-EST:fe2A5, CG10340" IPR010591:ATP11 CG10340 27-Aug-18 DroID_v2018_08 Drer\atpaf1 Scer\ATP11 - Xtro\atpaf1 Mmus\Atpaf1 Hsap\ATPAF1 "viable,fertile" FBgn0085786 CR41501 - http://flybase.org/reports/FBgn0085786 pseudogene_attribute - - - CR41501 - CR41501 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0037879 scpr-C SCP-containing protein C http://flybase.org/reports/FBgn0037879 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available extracellular region ; GO:0005576 | inferred from sequence model "SCPR-C, CG5106, BEST:CK01680, scpr-C, Scpr-C, scp-C, cg5106" "IPR001283:Cysteine-rich secretory protein, allergen V5/Tpx-1-related, IPR014044:CAP domain, IPR034763:Venom allergen 3, insect" CG5106 27-Aug-18 DroID_v2018_08 "Drer\r3hdml, Drer\glipr2, Drer\glipr2l, Drer\glipr1b, Drer\LOC101883528, Drer\crispld1b, Drer\LOC100536500, Drer\pi15b, Drer\pi15a, Drer\crispld1a, Drer\crispld2" "Scer\PRY2, Scer\PRY3, Scer\PRY1" "Cele\scl-6, Cele\scl-21, Cele\scl-2, Cele\scl-7, Cele\scl-14, Cele\scl-1, Cele\scl-20, Cele\scl-9, Cele\scl-19, Cele\scl-12, Cele\scl-10, Cele\scl-11, Cele\scl-18, Cele\scl-15, Cele\vap-2, Cele\scl-23, Cele\scl-8, Cele\scl-17, Cele\scl-3, Cele\scl-5, Cele\scl-13" "Xtro\MGC108118, Xtro\glipr2, Xtro\crispld2, Xtro\pi15, Xtro\crisp1, Xtro\crisp2, Xtro\r3hdml, Xtro\crisp3" "Mmus\Glipr1, Mmus\Glipr1l1, Mmus\Glipr1l2, Mmus\Pi16, Mmus\Pi15, Mmus\R3hdml, Mmus\Crispld2, Mmus\Crisp1, Mmus\Glipr2, Mmus\Crispld1, Mmus\Crisp4, Mmus\Clec18a, Mmus\Crisp2, Mmus\Crisp3" "Hsap\CRISPLD2, Hsap\GLIPR2, Hsap\CRISP1, Hsap\R3HDML, Hsap\GLIPR1L1, Hsap\CRISPLD1, Hsap\GLIPR1, Hsap\CLEC18A, Hsap\CLEC18B, Hsap\PI16, Hsap\CRISP2, Hsap\GLIPR1L2, Hsap\CLEC18C, Hsap\PI15" viable FBgn0034863 SkpF SKP1-related F http://flybase.org/reports/FBgn0034863 protein_coding_gene ubiquitin-protein transferase activity ; GO:0004842 | contributes_to inferred from sequence or structural similarity with SGD:S000002736 protein ubiquitination involved in ubiquitin-dependent protein catabolic process ; GO:0042787 | inferred from sequence or structural similarity with SGD:S000002736 SCF ubiquitin ligase complex ; GO:0019005 | inferred from sequence or structural similarity with SGD:S000002736 "CG12227, Skp, SkpF, skpF" "IPR011333:SKP1/BTB/POZ domain, IPR001232:S-phase kinase-associated protein 1-like, IPR016072:SKP1 component, dimerisation, IPR016073:SKP1 component, POZ domain, IPR016897:S-phase kinase-associated protein 1" CG12227 27-Aug-18 DroID_v2018_08 Drer\skp1 "Scer\SKP1, Scer\ELC1" "Cele\skr-6, Cele\skr-18, Cele\skr-20, Cele\skr-15, Cele\skr-10, Cele\skr-9, Cele\skr-21, Cele\skr-13, Cele\skr-16, Cele\skr-19, Cele\skr-7, Cele\skr-5, Cele\skr-17, Cele\skr-3, Cele\skr-14, Cele\skr-1, Cele\skr-8, Cele\skr-4, Cele\skr-12, Cele\skr-2" Xtro\skp1 Mmus\Skp1a Hsap\SKP1 FBgn0063388 snoRNA:U27:54Ea snoRNA:U27:54Ea http://flybase.org/reports/FBgn0063388 snoRNA_gene - - - "U27snoRNA, CR32892, snoRNA:U27:54Ea" - CR32892 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0005725 l(1)TK135 lethal (1) TK135 http://flybase.org/reports/FBgn0005725 - gene - - - "l135, l(1)TK135" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of larval stage,recessive,some die during larval stage" FBgn0259566 GG01373 - http://flybase.org/reports/FBgn0259566 gene - - - GG01373 - - 27-Aug-18 DroID_v2018_08 - - - - - - visible "antennal segment,wing" FBgn0004754 l(3)89Bg lethal (3) 89Bg http://flybase.org/reports/FBgn0004754 - gene - - - l(3)89Bg - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0021928 l(2)k11118 lethal (2) k11118 http://flybase.org/reports/FBgn0021928 - gene - - - l(2)k11118 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0265496 lncRNA:CR44365 - http://flybase.org/reports/FBgn0265496 non_protein_coding_gene - - - "CR44365, lincRNA.303" - CR44365 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0065476 l(2)SH1305 lethal (2) SH1305 http://flybase.org/reports/FBgn0065476 gene - - - "l(2)SH1305, l(2)SH2 1305" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0032361 CG6488 - http://flybase.org/reports/FBgn0032361 protein_coding_gene molecular_function ; GO:0003674 | no biological data available intra-Golgi vesicle-mediated transport ; GO:0006891 | inferred from biological aspect of ancestor with PANTHER:PTN000480807 intra-Golgi vesicle-mediated transport ; GO:0006891 | inferred from sequence or structural similarity with SGD:S000004536 Golgi transport complex ; GO:0017119 | inferred from direct assay "CG6488, Cog8" "IPR007255:Conserved oligomeric Golgi complex subunit 8, IPR016632:Conserved oligomeric Golgi complex subunit 8, Metazoal and Viridiplantae, IPR016159:Cullin repeat-like-containing domain" CG6488 27-Aug-18 DroID_v2018_08 Drer\cog8 Scer\COG8 Cele\cogc-8 Xtro\cog8 Mmus\Cog8 Hsap\COG8 "viable,fertile" FBgn0060673 l(3)S077801 lethal (3) S077801 http://flybase.org/reports/FBgn0060673 gene - - - "0778/01, l(3)S077801" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0061167 l(1)20BC lethal (1) 20BC http://flybase.org/reports/FBgn0061167 gene - - - l(1)20BC - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0002475 l(3)SG30 lethal (3) SG30 http://flybase.org/reports/FBgn0002475 - gene - - - "SG30, l(3)SG30" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of pupal stage,recessive,some die during pupal stage" eye-antennal disc FBgn0085453 CG34424 - http://flybase.org/reports/FBgn0085453 protein_coding_gene 5-formyltetrahydrofolate cyclo-ligase activity ; GO:0030272 | inferred from sequence or structural similarity with UniProtKB:P80405 5-formyltetrahydrofolate cyclo-ligase activity ; GO:0030272 | inferred from biological aspect of ancestor with PANTHER:PTN000601268 tetrahydrofolate interconversion ; GO:0035999 | inferred from biological aspect of ancestor with PANTHER:PTN000601268 folic acid-containing compound biosynthetic process ; GO:0009396 | inferred from biological aspect of ancestor with PANTHER:PTN000601268 cytosol ; GO:0005829 | inferred from sequence or structural similarity with UniProtKB:P80405 mitochondrion ; GO:0005739 | inferred from biological aspect of ancestor with PANTHER:PTN000601269 "CG34424, anon-WO0118547.139, CG11079" IPR002698:5-formyltetrahydrofolate cyclo-ligase CG34424 27-Aug-18 DroID_v2018_08 Drer\mthfs Scer\FAU1 Cele\Y106G6E.4 Xtro\mthfs "Mmus\Mthfs, Mmus\Mthfsl" "Hsap\ST20-MTHFS, Hsap\MTHFS" viable FBgn0065505 l(2)SH1197 lethal (2) SH1197 http://flybase.org/reports/FBgn0065505 gene - - - "l(2)SH1197, l(2)SH2 1197" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0021901 l(2)k12408 lethal (2) k12408 http://flybase.org/reports/FBgn0021901 - gene - - - l(2)k12408 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0030052 CG12065 - http://flybase.org/reports/FBgn0030052 protein_coding_gene catalytic activity ; GO:0003824 | inferred from electronic annotation with InterPro:IPR000845 nucleoside metabolic process ; GO:0009116 | inferred from electronic annotation with InterPro:IPR000845 lateral inhibition ; GO:0046331 | inferred from mutant phenotype - CG12065 "IPR011991:Winged helix-turn-helix DNA-binding domain, IPR000845:Nucleoside phosphorylase domain" CG12065 27-Aug-18 DroID_v2018_08 - - Cele\H14E04.2 - - - "viable,fertile,visible" "chaeta,supernumerary" FBgn0264282 Su(Mir)3C2-1 - http://flybase.org/reports/FBgn0264282 gene - - - Su(Mir)3C2-1 - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0053100 eIF4EHP eukaryotic translation initiation factor 4E homologous protein http://flybase.org/reports/FBgn0053100 protein_coding_gene translation initiation factor activity ; GO:0003743 | inferred from electronic annotation with InterPro:IPR001040 protein binding ; GO:0005515 | inferred from physical interaction with brat translation repressor activity ; GO:0030371 | inferred from genetic interaction with bcd RNA 7-methylguanosine cap binding ; GO:0000340 | inferred from direct assay protein binding ; GO:0005515 | inferred from physical interaction with bcd eukaryotic initiation factor 4G binding ; GO:0031370 | NOT inferred from direct assay translational initiation ; GO:0006413 | inferred from electronic annotation with InterPro:IPR001040 inter-male aggressive behavior ; GO:0002121 | inferred from mutant phenotype positive regulation of ecdysteroid biosynthetic process ; GO:0045998 | inferred from mutant phenotype neurogenesis ; GO:0022008 | inferred from mutant phenotype negative regulation of translation ; GO:0017148 | inferred from genetic interaction with bcd imaginal disc-derived wing morphogenesis ; GO:0007476 | inferred from mutant phenotype cytoplasm ; GO:0005737 | inferred from electronic annotation with InterPro:IPR001040 "4EHP, eIF4E-8, CG33100, d4EHP, CG10716, CT30033, 4E-HP, eIF4EHP" "IPR001040:Translation Initiation factor eIF- 4e, IPR023398:Translation Initiation factor eIF- 4e-like" CG33100 27-Aug-18 DroID_v2018_08 "Drer\eif4e2rs1, Drer\eif4e2" Scer\CDC33 Cele\ife-4 Xtro\eif4e2 Mmus\Eif4e2 Hsap\EIF4E2 "viable,fertile,behavior defective,recessive,partially lethal - majority die,maternal effect,some die during embryonic stage,lethal,neuroanatomy defective,visible,some die during pupal stage" "embryonic head segment,maternal effect,ganglion mother cell,trichogen cell,mesothoracic tergum" FBgn0265625 CG44433 - http://flybase.org/reports/FBgn0265625 protein_coding_gene - - - "CG15086, CG44433" - CG44433 27-Aug-18 DroID_v2018_08 - - Cele\Y32B12B.4 - - - FBgn0260807 EP3-980 - http://flybase.org/reports/FBgn0260807 gene - - - EP3-980 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0004719 ads all discs small http://flybase.org/reports/FBgn0004719 - gene - - - "l(3)ry100, l(3)ds16, ads" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0267617 asRNA:CR45955 - http://flybase.org/reports/FBgn0267617 non_protein_coding_gene - - - CR45955 - CR45955 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0023213 eIF4G1 eukaryotic translation initiation factor 4G1 http://flybase.org/reports/FBgn0023213 - protein_coding_gene "translation initiation factor activity ; GO:0003743 | inferred from sequence or structural similarity translation initiation factor activity ; GO:0003743 | inferred from sequence or structural similarity with HGNC:3296,SGD:S000003394 eukaryotic initiation factor 4E binding ; GO:0008190 | inferred from physical interaction with eIF4E1 RNA 7-methylguanosine cap binding ; GO:0000340 | inferred from direct assay eukaryotic initiation factor 4E binding ; GO:0008190 | inferred from physical interaction with eIF4E1 inferred from physical interaction with eIF4E4 inferred from physical interaction with eIF4E5 inferred from physical interaction with eIF4E7 inferred from physical interaction with eIF4E3 RNA binding ; GO:0003723 | inferred from direct assay" "mitotic G2 DNA damage checkpoint ; GO:0007095 | inferred from genetic interaction with nbs spermatid differentiation ; GO:0048515 | inferred from mutant phenotype translation ; GO:0006412 | inferred from direct assay G1/S transition of mitotic cell cycle ; GO:0000082 | inferred from mutant phenotype male germ-line cyst formation ; GO:0048136 | inferred from mutant phenotype spermatocyte division ; GO:0048137 | inferred from genetic interaction with eIF4G2 mitotic nuclear division ; GO:0007067 | inferred from mutant phenotype translational initiation ; GO:0006413 | inferred from sequence or structural similarity with HGNC:3296,SGD:S000003394 translational initiation ; GO:0006413 | inferred from sequence or structural similarity" eukaryotic translation initiation factor 4F complex ; GO:0016281 | inferred from direct assay cytosol ; GO:0005829 | inferred from sequence or structural similarity cytosol ; GO:0005829 | inferred from direct assay eukaryotic translation initiation factor 4F complex ; GO:0016281 | inferred from sequence or structural similarity "eIF4G, eIF4g, CG10811, Eif4G, p200, deIF4G, eIF-4G, EIF4G, eIF4G1" "IPR003307:W2 domain, IPR003890:MIF4G-like, type 3, IPR003891:Initiation factor eIF-4 gamma, MA3, IPR016024:Armadillo-type fold" CG10811 27-Aug-18 DroID_v2018_08 "Drer\eif4g3a, Drer\eif4g1a, Drer\eif4g1b, Drer\eif4g2b, Drer\eif4g3b, Drer\eif4g2a" "Scer\TIF4631, Scer\TIF4632" Cele\ifg-1 "Xtro\eif4g3, Xtro\LOC100145496" "Mmus\Eif4g3, Mmus\Eif4g2, Mmus\Eif4g1" "Hsap\EIF4G3, Hsap\EIF4G1, Hsap\EIF4G2" lethal DRSC17218 IE 0.876038645 -2.069641687 -2.405192068 -1.40025058 -1.066382831 -0.527779547 FBgn0022265 l(2)k00611 lethal (2) k00611 http://flybase.org/reports/FBgn0022265 - gene - - - l(2)k00611 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0000025 acj1 abnormal chemosensory jump 1 http://flybase.org/reports/FBgn0000025 - gene molecular_function ; GO:0003674 | no biological data available chemosensory jump behavior ; GO:0007636 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available acj1 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0265212 fs(2)Z2-147 - http://flybase.org/reports/FBgn0265212 gene - - - fs(2)Z2-147 - - 27-Aug-18 DroID_v2018_08 - - - - - - female sterile FBgn0010140 l(2)DTS486 lethal (2) DTS486 http://flybase.org/reports/FBgn0010140 - gene - - - "DTS486, l(2)DTS486" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,dominant,partially,heat sensitive,female sterile" FBgn0031183 CG14621 - http://flybase.org/reports/FBgn0031183 protein_coding_gene - biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG14621, Slc35e1, lincRNA.1043" IPR004853:Sugar phosphate transporter domain CG14621 27-Aug-18 DroID_v2018_08 "Drer\slc35e3, Drer\slc35e4, Drer\slc35e1, Drer\si:ch73-236j9.2" "Scer\YJL193W, Scer\SLY41" - "Xtro\siah3, Xtro\slc35e1" "Mmus\Slc35e4, Mmus\Slc35e2, Mmus\Slc35e1, Mmus\Slc35e3" "Hsap\SLC35E2B, Hsap\SLC35E3, Hsap\SLC35E1, Hsap\SLC35E4, Hsap\SLC35E2" viable FBgn0005025 dumpyoidy dumpyoidy http://flybase.org/reports/FBgn0005025 - gene - - - "dpy, dumpyoidy" - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,recessive" wing FBgn0031971 Sirup Starvation-upregulated protein http://flybase.org/reports/FBgn0031971 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "anon-EST:Posey12, BcDNA:GH18422, dSdhaf4, CG7224, Sirup, Sdhaf4" IPR012875:Protein of unknown function DUF1674 CG7224 27-Aug-18 DroID_v2018_08 Drer\sdhaf4 Scer\SDH8 Cele\W02D3.12 Xtro\sdhaf4 Mmus\Sdhaf4 Hsap\SDHAF4 "visible,partially lethal - majority die,some die during pupal stage" mesothoracic tergum FBgn0047095 CG33939 - http://flybase.org/reports/FBgn0047095 protein_coding_gene - - - "CR33939, BcDNA:RE54004, CG33939, pncr004:X" - CG33939 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0015539 scs special chromatin structure http://flybase.org/reports/FBgn0015539 - insulator - - - "scs, SCS" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0028544 CG16884 - http://flybase.org/reports/FBgn0028544 protein_coding_gene - wing disc development ; GO:0035220 | inferred from mutant phenotype - "BG:DS00180.3, CG16884, vajk-3" - CG16884 27-Aug-18 DroID_v2018_08 - - Cele\T26C11.2 - Mmus\Ggn "Hsap\ZNF512B, Hsap\TPRX1, Hsap\GGN" "visible,size defective" "wing vein L3,wing vein L4,anterior crossvein,ectopic,posterior crossvein,wing,posterior,wing cell" FBgn0060837 l(3)S049610 lethal (3) S049610 http://flybase.org/reports/FBgn0060837 gene - - - "0496/10, l(3)S049610" - - 27-Aug-18 DroID_v2018_08 - - - - - - "partially lethal - majority die,recessive" FBgn0032669 CG15155 - http://flybase.org/reports/FBgn0032669 protein_coding_gene "transferase activity, transferring acyl groups other than amino-acyl groups ; GO:0016747 | inferred from electronic annotation with InterPro:IPR013653" - - "CT35055, CG15155" "IPR016181:Acyl-CoA N-acyltransferase, IPR013653:FR47-like" CG15155 27-Aug-18 DroID_v2018_08 "Drer\si:ch73-106k19.2, Drer\si:dkey-76k16.5, Drer\si:dkey-76k16.6" - Cele\ZK185.3 - - Hsap\GLYATL3 viable FBgn0050402 CG30402 - http://flybase.org/reports/FBgn0050402 protein_coding_gene - - - CG30402 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0030310 PGRP-SA Peptidoglycan recognition protein SA http://flybase.org/reports/FBgn0030310 protein_coding_gene zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR006619 peptidoglycan binding ; GO:0042834 | non-traceable author statement peptidoglycan receptor activity ; GO:0016019 | inferred from sequence or structural similarity with UniProtKB:O76537 peptidoglycan receptor activity ; GO:0016019 | non-traceable author statement peptidoglycan binding ; GO:0042834 | inferred from direct assay peptidoglycan binding ; GO:0042834 | traceable author statement signaling pattern recognition receptor activity ; GO:0008329 | traceable author statement peptidoglycan binding ; GO:0042834 | non-traceable author statement inferred from direct assay protein binding ; GO:0005515 | inferred from physical interaction with GNBP1 N-acetylmuramoyl-L-alanine amidase activity ; GO:0008745 | NOT inferred from key residues muramyl dipeptide binding ; GO:0032500 | inferred from direct assay peptidoglycan receptor activity ; GO:0016019 | traceable author statement innate immune response ; GO:0045087 | inferred from electronic annotation with InterPro:IPR017331 defense response to Gram-positive bacterium ; GO:0050830 | inferred from genetic interaction with GNBP1 positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria ; GO:0006965 | inferred from mutant phenotype innate immune response ; GO:0045087 | non-traceable author statement peptidoglycan catabolic process ; GO:0009253 | NOT inferred from key residues defense response to Gram-positive bacterium ; GO:0050830 | inferred from direct assay peptidoglycan catabolic process ; GO:0009253 | non-traceable author statement immune response ; GO:0006955 | inferred from sequence or structural similarity with UniProtKB:O76537 response to peptidoglycan ; GO:0032494 | inferred from mutant phenotype regulation of Toll signaling pathway ; GO:0008592 | traceable author statement Toll signaling pathway ; GO:0008063 | traceable author statement positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria ; GO:0006965 | traceable author statement immune response ; GO:0006955 | traceable author statement defense response to Gram-positive bacterium ; GO:0050830 | traceable author statement innate immune response ; GO:0045087 | traceable author statement extracellular region ; GO:0005576 | inferred from sequence or structural similarity extracellular region ; GO:0005576 | inferred from direct assay "seml, SEMMELWEIS, CG11709, BcDNA:AT30827, PGRP-SA, Dm PGRP-SA, SA, pgrp-sa" "IPR002502:N-acetylmuramoyl-L-alanine amidase domain, IPR006619:Peptidoglycan recognition protein family domain, metazoa/bacteria, IPR015510:Peptidoglycan recognition protein, IPR017331:Peptidoglycan recognition protein, PGRP-S" CG11709 27-Aug-18 DroID_v2018_08 "Drer\pglyrp6, Drer\pglyrp2, Drer\pglyrp5" - - "Xtro\pglyrp1, Xtro\pglyrp2, Xtro\pglyrp1" "Mmus\Pglyrp3, Mmus\Pglyrp4, Mmus\Pglyrp1, Mmus\Pglyrp2" "Hsap\PGLYRP1, Hsap\PGLYRP3, Hsap\PGLYRP4, Hsap\PGLYRP2" "immune response defective,viable" FBgn0040398 CG14629 - http://flybase.org/reports/FBgn0040398 protein_coding_gene - - - "EG:103E12.2, CG14629" IPR009832:Protein of unknown function DUF1397 CG14629 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0033041 Or42a Odorant receptor 42a http://flybase.org/reports/FBgn0033041 protein_coding_gene odorant binding ; GO:0005549 | inferred from sequence or structural similarity with Or43b olfactory receptor activity ; GO:0004984 | inferred from biological aspect of ancestor with PANTHER:PTN000474402 detection of chemical stimulus involved in sensory perception of smell ; GO:0050911 | inferred from mutant phenotype olfactory behavior ; GO:0042048 | inferred from mutant phenotype plasma membrane ; GO:0005886 | inferred from biological aspect of ancestor with PANTHER:PTN000474402 dendrite membrane ; GO:0032590 | inferred from sequence or structural similarity with Or22a integral component of membrane ; GO:0016021 | inferred from biological aspect of ancestor with PANTHER:PTN000474402 "Or42a, 42a, DOR117, 41E.2, CG17250, Or42A, OR42a" "IPR004117:Olfactory receptor, insect" CG17250 27-Aug-18 DroID_v2018_08 - - - - - - "smell perception defective,viable,fertile" adult olfactory receptor neuron Or42a FBgn0000306 che cherub http://flybase.org/reports/FBgn0000306 - gene - - - che - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,recessive,male sterile,sterile,female sterile" wing FBgn0024631 l(2)k14316 lethal (2) k14316 http://flybase.org/reports/FBgn0024631 - gene - - - "143/16, l(2)k14316" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0001278 J Jammed http://flybase.org/reports/FBgn0001278 - gene - - - J - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,heat sensitive,viable,lethal,recessive,reduced" "wing,alula" FBgn0015584 Acp53Ea Accessory gland protein 53Ea http://flybase.org/reports/FBgn0015584 FBgn0063350 protein_coding_gene - multicellular organism reproduction ; GO:0032504 | inferred from expression pattern sperm competition ; GO:0046692 | traceable author statement extracellular space ; GO:0005615 | inferred from direct assay extracellular space ; GO:0005615 | inferred from sequence model "Acp53E, BcDNA:AT09943, CG8622, Acp53Ea, ACP53EA" IPR009392:Drosophila ACP53EA CG8622 27-Aug-18 DroID_v2018_08 - - - - - - adult stage | male " male accessory gland

, male accessory gland main cell

" viable FBgn0042165 CG18845 - http://flybase.org/reports/FBgn0042165 protein_coding_gene - - - CG18845 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0022257 l(2)k01006 lethal (2) k01006 http://flybase.org/reports/FBgn0022257 - gene - - - l(2)k01006 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0039453 CG6403 - http://flybase.org/reports/FBgn0039453 protein_coding_gene chitin binding ; GO:0008061 | inferred from electronic annotation with InterPro:IPR002557 chitin metabolic process ; GO:0006030 | inferred from electronic annotation with InterPro:IPR002557 extracellular region ; GO:0005576 | inferred from electronic annotation with InterPro:IPR002557 CG6403 IPR002557:Chitin binding domain CG6403 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0037120 CG11247 - http://flybase.org/reports/FBgn0037120 protein_coding_gene nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR013087 regulation of cell cycle ; GO:0051726 | inferred from direct assay - CG11247 "IPR013087:Zinc finger C2H2-type, IPR013083:Zinc finger, RING/FYVE/PHD-type" CG11247 27-Aug-18 DroID_v2018_08 "Drer\zgc:113452, Drer\znf410, Drer\LOC100535506, Drer\si:dkeyp-2e4.8, Drer\zgc:174623, Drer\zgc:171422, Drer\si:dkey-253d23.2" "Scer\ZAP1, Scer\PZF1" "Cele\hinf-1, Cele\C27A12.2, Cele\ztf-23, Cele\sem-4, Cele\eor-1, Cele\fezf-1, Cele\blmp-1, Cele\Y5F2A.4, Cele\lst-5, Cele\Y55F3AM.14, Cele\let-391" Xtro\znf410 "Mmus\Zfp3, Mmus\Zfp639, Mmus\Zfp410, Mmus\Zfp354b, Mmus\Zfp473, Mmus\Zfp354a" "Hsap\ZNF99, Hsap\ZSCAN20, Hsap\ZNF133, Hsap\ZNF639, Hsap\ZNF410, Hsap\ZNF564" "viable,fertile" DRSC26558 K -0.214621344 0.430984818 0.101049218 -0.17493128 0.429641584 -1.529961902 FBgn0039955 CG41099 - http://flybase.org/reports/FBgn0039955 protein_coding_gene metal ion binding ; GO:0046872 | inferred from electronic annotation with InterPro:IPR000306 embryonic morphogenesis ; GO:0048598 | inferred from mutant phenotype endocytosis ; GO:0006897 | inferred from mutant phenotype epithelial cell morphogenesis ; GO:0003382 | inferred from mutant phenotype vacuole ; GO:0005773 | inferred from direct assay "CG41099, CG17419, CG17416, GM10035, BEST:GM10035" "IPR000210:BTB/POZ domain, IPR000306:FYVE zinc finger, IPR002110:Ankyrin repeat, IPR011011:Zinc finger, FYVE/PHD-type, IPR011333:SKP1/BTB/POZ domain, IPR017455:Zinc finger, FYVE-related, IPR020683:Ankyrin repeat-containing domain, IPR013083:Zinc finger, RING/FYVE/PHD-type" CG41099 27-Aug-18 DroID_v2018_08 "Drer\ankrd55, Drer\si:ch211-11n16.2, Drer\zak, Drer\ankfy1, Drer\hgs, Drer\ripk3, Drer\ank2a, Drer\dstyk, Drer\ripk4, Drer\zfyve19, Drer\pbk, Drer\ripk2, Drer\ank3b, Drer\LOC405768, Drer\map3k10, Drer\map3k9, Drer\zfyve1, Drer\lrrk2, Drer\mos, Drer\ripk1l, Drer\ank3a, Drer\ank1b, Drer\si:ch211-120p12.3" "Scer\YGL242C, Scer\MGA2, Scer\YCR051W, Scer\VPS27, Scer\SPT23" "Cele\T28D6.4, Cele\F22G12.4, Cele\dhhc-13" "Xtro\lrrk2, Xtro\ank3, Xtro\zfyve19, Xtro\ankk1, Xtro\lrrk1, Xtro\ripk1, Xtro\ank2, Xtro\ank1, Xtro\dstyk, Xtro\hgs, Xtro\mlkl, Xtro\pbk, Xtro\map3k9, Xtro\LOC100490493, Xtro\ankfy1, Xtro\zak, Xtro\zfyve1, Xtro\ripk4, Xtro\map3k7, Xtro\map3k10" "Mmus\Zfyve1, Mmus\Mos, Mmus\Ankrd55, Mmus\Map3k11, Mmus\Ank1, Mmus\BC021891, Mmus\Ank2, Mmus\Map3k9, Mmus\Ripk1, Mmus\Mlkl, Mmus\Pbk, Mmus\Hgs, Mmus\Map3k10, Mmus\Lrrk1, Mmus\Ripk2, Mmus\Zfyve19, Mmus\Ripk4, Mmus\Zak, Mmus\Map3k7, Mmus\Ank3, Mmus\Dstyk, Mmus\Lrrk2, Mmus\Ankfy1, Mmus\Ripk3" "Hsap\PBK, Hsap\ZFYVE19, Hsap\ANK3, Hsap\RIPK4, Hsap\RIPK2, Hsap\ZFYVE1, Hsap\LRRK1, Hsap\MAP3K20, Hsap\ANKRD55, Hsap\HGS, Hsap\LRRK2, Hsap\MAP3K9, Hsap\DSTYK, Hsap\MAP3K11, Hsap\ANK1, Hsap\ANKFY1, Hsap\RIPK3, Hsap\MLKL, Hsap\MOS, Hsap\RIPK1, Hsap\MAP3K21, Hsap\MAP3K10, Hsap\MAP3K7, Hsap\ANK2" viable FBgn0266736 asRNA:CR45209 - http://flybase.org/reports/FBgn0266736 non_protein_coding_gene - - - CR45209 - CR45209 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0262402 mir-311 mir-311 stem loop http://flybase.org/reports/FBgn0262402 miRNA_gene - response to nicotine ; GO:0035094 | inferred from mutant phenotype dorsal closure ; GO:0007391 | inferred from mutant phenotype head involution ; GO:0008258 | inferred from mutant phenotype cellular response to nitric oxide ; GO:0071732 | inferred from direct assay - "mir-311, miR-311, 311, Dme-miR-311, CR42943, CR33615, dme-mir-311, dme-miR-311, mIR-311" - CR42943 27-Aug-18 DroID_v2018_08 - - - - - - "viable,visible,lethal - all die before end of P-stage,some die during pharate adult stage,lethal,partially lethal - majority die" "wing,wing vein,1st posterior cell" FBgn0030786 mRpL22 mitochondrial ribosomal protein L22 http://flybase.org/reports/FBgn0030786 protein_coding_gene structural constituent of ribosome ; GO:0003735 | inferred from sequence or structural similarity with EMBL:AA772054 structural constituent of ribosome ; GO:0003735 | traceable author statement mitochondrial translation ; GO:0032543 | traceable author statement translation ; GO:0006412 | inferred from sequence or structural similarity with EMBL:AA772054 mitochondrion ; GO:0005739 | inferred from sequence or structural similarity with UniProtKB:Q3SZX5 mitochondrial large ribosomal subunit ; GO:0005762 | inferred from sequence or structural similarity with EMBL:AA772054 mitochondrial large ribosomal subunit ; GO:0005762 | traceable author statement mitochondrial large ribosomal subunit ; GO:0005762 | inferred from sequence or structural similarity with UniProtKB:Q9NWU5 "CG4742, L22, mRpL22" "IPR001063:Ribosomal protein L22/L17, IPR005727:Ribosomal protein L22, bacterial/chloroplast-type" CG4742 27-Aug-18 DroID_v2018_08 Drer\mrpl22 "Scer\RPL17B, Scer\MRPL22, Scer\RPL17A" Cele\mrpl-22 Xtro\mrpl22 Mmus\Mrpl22 Hsap\MRPL22 "viable,visible" "trichogen cell,mesothoracic tergum" DRSC19915 K -0.906735727 -0.25072513 -0.178543384 -0.409460697 -1.94043949 -0.252965782 FBgn0069402 KH3 KH3 http://flybase.org/reports/FBgn0069402 gene molecular_function ; GO:0003674 | no biological data available - cellular_component ; GO:0005575 | no biological data available KH3 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0001728 l(1)ESHS49 lethal (1) ESHS49 http://flybase.org/reports/FBgn0001728 - gene - - - l(1)ESHS49 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0025814 Mgstl Microsomal glutathione S-transferase-like http://flybase.org/reports/FBgn0025814 "FBgn0031147, FBgn0047002, FBgn0061409" protein_coding_gene glutathione transferase activity ; GO:0004364 | inferred from sequence or structural similarity with UniProtKB:P10620 glutathione transferase activity ; GO:0004364 | inferred from sequence or structural similarity with HGNC:7061 - mitochondrial outer membrane ; GO:0005741 | inferred from sequence or structural similarity with UniProtKB:P10620 intracellular membrane-bounded organelle ; GO:0043231 | inferred from sequence or structural similarity with HGNC:7061 lipid particle ; GO:0005811 | inferred from direct assay intracellular membrane-bounded organelle ; GO:0043231 | inferred from sequence or structural similarity with UniProtKB:P10620 "Mgst1, CG1742, BcDNA:RH59553, BcDNA:RE10696, Mgstl" "IPR001129:Membrane-associated, eicosanoid/glutathione metabolism (MAPEG) protein, IPR023352:Membrane associated eicosanoid/glutathione metabolism-like domain" CG1742 27-Aug-18 DroID_v2018_08 "Drer\mgst1.2, Drer\mgst1.1, Drer\ptges" - - "Xtro\ptges, Xtro\mgst1" "Mmus\Mgst1, Mmus\Ptges" "Hsap\PTGES, Hsap\MGST1" "partially lethal - majority die,visible,viable,fertile,short lived" "eye,arista,tarsal segment,macrochaeta,wing,scutellum" FBgn0063356 CR30370 - http://flybase.org/reports/FBgn0063356 non_protein_coding_gene - - - "BcDNA:AT05157, CR30370" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0023083 fray frayed http://flybase.org/reports/FBgn0023083 "FBgn0010922, FBgn0026023" protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441, InterPro:IPR024678 receptor signaling protein serine/threonine kinase activity ; GO:0004702 | inferred from biological aspect of ancestor with PANTHER:PTN000684825 receptor signaling protein serine/threonine kinase activity ; GO:0004702 | non-traceable author statement protein serine/threonine kinase activity ; GO:0004674 | inferred from mutant phenotype" "chitin-based embryonic cuticle biosynthetic process ; GO:0008362 | inferred from mutant phenotype wing disc development ; GO:0035220 | inferred from mutant phenotype establishment of blood-nerve barrier ; GO:0008065 | inferred from mutant phenotype axon ensheathment ; GO:0008366 | inferred from mutant phenotype protein phosphorylation ; GO:0006468 | non-traceable author statement protein localization to cell cortex ; GO:0072697 | inferred from genetic interaction with mira, Lkb1 protein phosphorylation ; GO:0006468 | inferred from mutant phenotype protein autophosphorylation ; GO:0046777 | inferred from direct assay" cytoplasm ; GO:0005737 | inferred from direct assay "STE20-like/SPAK, CG7693, l(3)07551, lag, 4624, fray, Fray, dSTRAD, dOSR1, Dosr1" "IPR000719:Protein kinase domain, IPR011009:Protein kinase-like domain, IPR017441:Protein kinase, ATP binding site, IPR024678:Serine/threonine-protein kinase OSR1/WNK, CCT domain" CG7693 27-Aug-18 DroID_v2018_08 "Drer\oxsr1b, Drer\stk39, Drer\oxsr1a, Drer\wu:fj77h11" Scer\STE20 "Cele\hpo-11, Cele\gck-3" "Xtro\strada, Xtro\stk39, Xtro\stradb" "Mmus\Oxsr1, Mmus\Stk39, Mmus\Stradb, Mmus\Strada" "Hsap\STK39, Hsap\STRADA, Hsap\OXSR1, Hsap\STRADB" " embryonic stage | stage >=15 , embryonic stage | stage >=12 , embryonic stage | early , embryonic stage | stage 17 " " abdominal ventral oblique muscle 6

, larval hindgut

, exit glial cell

, larval midgut

, larval proventriculus

, dorsal neurohemal organ

" "visible,viable,fertile,lethal,recessive,maternal effect,lethal - all die before end of larval stage,some die during larval stage" "wing vein,ectopic,wing vein L4,embryonic/first instar larval cuticle,maternal effect,embryonic/larval peripheral nervous system,trichogen cell,posterior wing margin" DRSC16950 K 0.194590866 0.670186911 1.095502173 0.002877787 1.959282807 0.23182972 FBgn0040692 CG13938 - http://flybase.org/reports/FBgn0040692 protein_coding_gene - - - CG13938 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0039912 CG11260 - http://flybase.org/reports/FBgn0039912 protein_coding_gene - - - CG11260 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0019784 l(1)218 lethal (1) 218 http://flybase.org/reports/FBgn0019784 - gene - - - l(1)218 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,partially,recessive" FBgn0038392 CG17631 - http://flybase.org/reports/FBgn0038392 protein_coding_gene - - - CG17631 - - 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0033899 CG13016 - http://flybase.org/reports/FBgn0033899 protein_coding_gene - - - CG13016 IPR019397:Uncharacterised protein family TMEM39 CG13016 27-Aug-18 DroID_v2018_08 "Drer\tmem39b, Drer\tmem39a" - Cele\D1007.5 "Xtro\tmem39b, Xtro\tmem39a" "Mmus\Tmem39b, Mmus\Tmem39a" "Hsap\TMEM39A, Hsap\TMEM39B" viable FBgn0001730 l(1)ESHS51 lethal (1) ESHS51 http://flybase.org/reports/FBgn0001730 - gene - - - l(1)ESHS51 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0083960 CG34124 - http://flybase.org/reports/FBgn0083960 protein_coding_gene molecular_function ; GO:0003674 | no biological data available cilium-dependent cell motility ; GO:0060285 | inferred from biological aspect of ancestor with PANTHER:PTN000346980 cellular_component ; GO:0005575 | no biological data available "CG31652, CG34124" "IPR011047:Quinoprotein alcohol dehydrogenase-like superfamily, IPR001680:WD40 repeat, IPR017986:WD40-repeat-containing domain, IPR015943:WD40/YVTN repeat-like-containing domain" CG34124 27-Aug-18 DroID_v2018_08 Drer\si:dkey-1f12.3 - - "Xtro\cfap44, Xtro\eml6" "Mmus\Eml5, Mmus\Cfap44, Mmus\Eml6" "Hsap\CFAP44, Hsap\EML6, Hsap\EML5" "viable,fertile" FBgn0065472 l(2)SH1328 lethal (2) SH1328 http://flybase.org/reports/FBgn0065472 gene - - - "l(2)SH1328, l(2)SH2 1328" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0031347 CG10869 - http://flybase.org/reports/FBgn0031347 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG10869 IPR032013:Protein of unknown function DUF4795 CG10869 27-Aug-18 DroID_v2018_08 - - - - "Mmus\4930562C15Rik, Mmus\Qrich2" "Hsap\QRICH2, Hsap\C16orf96" viable FBgn0041007 CG17541 - http://flybase.org/reports/FBgn0041007 protein_coding_gene - - - CG17541 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0260350 GSd302 - http://flybase.org/reports/FBgn0260350 gene - - - GSd302 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,neuroanatomy defective" "ventral nerve cord,intersegmental nerve,segmental nerve" FBgn0038722 Nup58 Nucleoporin 58kD http://flybase.org/reports/FBgn0038722 protein_coding_gene nucleocytoplasmic transporter activity ; GO:0005487 | inferred from biological aspect of ancestor with PANTHER:PTN001412288 nucleocytoplasmic transporter activity ; GO:0005487 | inferred from sequence or structural similarity with UniProtKB:P70581 nuclear localization sequence binding ; GO:0008139 | inferred from biological aspect of ancestor with PANTHER:PTN001412288 protein import into nucleus ; GO:0006606 | inferred from biological aspect of ancestor with PANTHER:PTN001412288 neuron projection morphogenesis ; GO:0048812 | inferred from mutant phenotype nucleocytoplasmic transport ; GO:0006913 | inferred from sequence or structural similarity with UniProtKB:P70581 nuclear pore ; GO:0005643 | inferred from biological aspect of ancestor with PANTHER:PTN001412288 nuclear pore ; GO:0005643 | inferred from sequence or structural similarity with UniProtKB:P70581 "CG7360, Nup58, Dm NUP58, RE52572p" "IPR024945:Spt5 C-terminal domain, IPR024882:Nucleoporin p58/p45" CG7360 27-Aug-18 DroID_v2018_08 "Drer\nup58, Drer\nup98, Drer\nup62l" "Scer\NUP100, Scer\NSP1, Scer\NUP49, Scer\NUP145, Scer\NUP116" "Cele\npp-11, Cele\npp-10" Xtro\nup58 "Mmus\Nup98, Mmus\Nup62, Mmus\Nup62cl, Mmus\Nupl1" "Hsap\NUP98, Hsap\NUP58, Hsap\NUP62" "sterile,partially lethal,viable" FBgn0037985 ssp5 short spindle 5 http://flybase.org/reports/FBgn0037985 protein_coding_gene - - - "anon-WO0140519.127, ssp5, CG14735, Ssp5, Tes59" "IPR031936:Domain of unknown function DUF4771, IPR031935:Domain of unknown function DUF4770" CG14735 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0036490 CG6888 - http://flybase.org/reports/FBgn0036490 protein_coding_gene thioredoxin peroxidase activity ; GO:0008379 | inferred from sequence or structural similarity with HGNC:9352 "cell redox homeostasis ; GO:0045454 | inferred from electronic annotation with InterPro:IPR013766 oxidation-reduction process ; GO:0055114 | inferred from electronic annotation with InterPro:IPR000866, InterPro:IPR019479 hydrogen peroxide catabolic process ; GO:0042744 | inferred from sequence or structural similarity with HGNC:9352 cellular response to DNA damage stimulus ; GO:0006974 | inferred from mutant phenotype" cytoplasm ; GO:0005737 | inferred from sequence or structural similarity with HGNC:9352 extracellular exosome ; GO:0070062 | inferred from sequence or structural similarity with HGNC:9352 "BcDNA:AT16346, CG6888, 6888" "IPR000866:Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant, IPR012336:Thioredoxin-like fold, IPR019479:Peroxiredoxin, C-terminal, IPR024706:Peroxiredoxin, AhpC-type, IPR013766:Thioredoxin domain" CG6888 27-Aug-18 DroID_v2018_08 "Drer\prdx4, Drer\prdx3, Drer\prdx6, Drer\prdx1, Drer\prdx2" "Scer\PRX1, Scer\TSA1, Scer\TSA2" "Cele\prdx-2, Cele\prdx-6, Cele\prdx-3" "Xtro\prdx2, Xtro\prdx3, Xtro\prdx1, Xtro\prdx4" "Mmus\Prdx3, Mmus\Prdx1, Mmus\Prdx2, Mmus\Prdx6, Mmus\Prdx4" "Hsap\PRDX1, Hsap\PRDX4, Hsap\PRDX6, Hsap\PRDX3, Hsap\PRDX2" "viable,fertile" FBgn0005601 yemG2.8 yema gene 2.8 http://flybase.org/reports/FBgn0005601 FBgn0004042 gene - - - "yG2.8/2.6, yG2.8, yG2.6, yT2.8, yT2.6, yemG2.8" - - 27-Aug-18 DroID_v2018_08 - - - - - - " adult stage && oogenesis stage , embryonic stage | stage <=8 , embryonic stage | stage <6 , embryonic stage | stage <= 8 " " ovary

, organism

" FBgn0027560 Tps1 Trehalose-6-phosphate synthase 1 http://flybase.org/reports/FBgn0027560 "FBgn0001908, FBgn0022028" protein_coding_gene trehalose-phosphatase activity ; GO:0004805 | inferred from direct assay trehalose metabolism in response to stress ; GO:0070413 | inferred from biological aspect of ancestor with PANTHER:PTN000082159 photoreceptor cell maintenance ; GO:0045494 | inferred from mutant phenotype trehalose biosynthetic process ; GO:0005992 | inferred from mutant phenotype cytoplasm ; GO:0005737 | inferred from biological aspect of ancestor with PANTHER:PTN000082159 lipid particle ; GO:0005811 | inferred from direct assay "BcDNA:GH08860, tps1, TreS, CG4104, dtps1, TPS, jf5, l(2)k08903, l(2)jf5, l(2)jf4, l(2)24Ea, Tps1, CG4104 PA, dTps1, 19920676" "IPR001830:Glycosyl transferase, family 20, IPR003337:Trehalose-phosphatase, IPR006379:HAD-superfamily hydrolase, subfamily IIB, IPR023214:HAD-like domain" CG4104 27-Aug-18 DroID_v2018_08 - "Scer\TPS2, Scer\TPS3, Scer\TSL1, Scer\TPS1" "Cele\tps-1, Cele\tps-2, Cele\gob-1" - - - "lethal,recessive,lethal - all die before end of larval stage,some die during larval stage,visible,lethal - all die before end of pupal stage,heat sensitive,some die during pupal stage" "eye,ommatidium" FBgn0002995 om ommatidia http://flybase.org/reports/FBgn0002995 - gene - - - om - - 27-Aug-18 DroID_v2018_08 - - - - - - "eye,ommatidium" FBgn0030799 CG4872 - http://flybase.org/reports/FBgn0030799 protein_coding_gene "transcription corepressor activity ; GO:0003714 | inferred from sequence or structural similarity with HGNC:2418 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor ; GO:0016639 | inferred from biological aspect of ancestor with PANTHER:PTN000352164 hormone binding ; GO:0042562 | inferred from biological aspect of ancestor with PANTHER:PTN001013561" negative regulation of transcription from RNA polymerase II promoter ; GO:0000122 | inferred from sequence or structural similarity with HGNC:2418 cytoplasm ; GO:0005737 | inferred from sequence or structural similarity with HGNC:2418 cytoplasm ; GO:0005737 | inferred from biological aspect of ancestor with PANTHER:PTN000352164 CG4872 "IPR003462:Ornithine cyclodeaminase/mu-crystallin, IPR016040:NAD(P)-binding domain, IPR023401:Ornithine cyclodeaminase, N-terminal" CG4872 27-Aug-18 DroID_v2018_08 Drer\crym Scer\YGL159W - Xtro\crym Mmus\Crym Hsap\CRYM FBgn0015857 anon-14Aa anon-14Aa http://flybase.org/reports/FBgn0015857 - gene - - - "t6, anon-14Aa" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0005704 l(1)TK107 lethal (1) TK107 http://flybase.org/reports/FBgn0005704 - gene - - - "l107, l(1)TK107" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" "eye,lamina" FBgn0019701 l(2)42Bb lethal (2) 42Bb http://flybase.org/reports/FBgn0019701 - gene - - - "l(2)6G1, 6G1, l(2)42Bb" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0045473 Gr85a Gustatory receptor 85a http://flybase.org/reports/FBgn0045473 protein_coding_gene taste receptor activity ; GO:0008527 | non-traceable author statement sensory perception of taste ; GO:0050909 | inferred from electronic annotation with InterPro:IPR013604 sensory perception of taste ; GO:0050909 | non-traceable author statement integral component of membrane ; GO:0016021 | inferred from electronic annotation with InterPro:IPR013604 integral component of membrane ; GO:0016021 | non-traceable author statement "CG31405, Gr85a" IPR013604:7TM chemoreceptor CG31405 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0267426 CR45779 - http://flybase.org/reports/FBgn0267426 pseudogene_attribute - - - "CR45779, Mst77Y" - CR45779 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0010849 l(3)04837 lethal (3) 04837 http://flybase.org/reports/FBgn0010849 - gene molecular_function ; GO:0003674 | no biological data available segmentation ; GO:0035282 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available l(3)04837 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive,maternal effect,poor" "embryonic/first instar larval cuticle,maternal effect,segment" FBgn0060753 l(3)S064318 lethal (3) S064318 http://flybase.org/reports/FBgn0060753 gene - - - "0643/18, l(3)S064318" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,lethal - all die before end of larval stage,recessive,some die during larval stage" FBgn0001596 l(1)carot14 lethal (1) carot14 http://flybase.org/reports/FBgn0001596 - gene - - - "l(1)TW5, l(1)carot14" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive,visible,female sterile" "wing,adult abdomen" FBgn0030613 Rab3-GEF Rab3 GDP-GTP exchange factor http://flybase.org/reports/FBgn0030613 protein_coding_gene Rab guanyl-nucleotide exchange factor activity ; GO:0017112 | inferred from biological aspect of ancestor with PANTHER:PTN000988808 Rab guanyl-nucleotide exchange factor activity ; GO:0017112 | inferred from sequence or structural similarity with UniProtKB:Q8WXG6 regulation of extrinsic apoptotic signaling pathway via death domain receptors ; GO:1902041 | inferred from sequence or structural similarity with UniProtKB:Q8WXG6 activation of MAPK activity ; GO:0000187 | inferred from sequence or structural similarity with UniProtKB:Q8WXG6 cytoskeletal matrix organization at active zone ; GO:0048789 | inferred from mutant phenotype regulation of Rab protein signal transduction ; GO:0032483 | inferred from sequence or structural similarity with HGNC:6766 neurotransmitter secretion ; GO:0007269 | non-traceable author statement vesicle-mediated transport ; GO:0016192 | non-traceable author statement regulation of cell cycle ; GO:0051726 | inferred from sequence or structural similarity with UniProtKB:Q8WXG6 neuromuscular junction of somatic muscle ; GO:0098527 | inferred from direct assay integral component of membrane ; GO:0016021 | inferred from sequence or structural similarity with UniProtKB:Q8WXG6 neuronal cell body ; GO:0043025 | inferred from direct assay synaptic vesicle ; GO:0008021 | non-traceable author statement terminal bouton ; GO:0043195 | inferred from direct assay "CG5627, BEST:GH21304, anon-EST:Posey246, rab3-GEF, Rab3-GEF" "IPR001194:DENN domain, IPR005112:dDENN domain, IPR005113:uDENN domain" CG5627 27-Aug-18 DroID_v2018_08 Drer\madd - "Cele\aex-3, Cele\mtm-5" Xtro\madd Mmus\Madd Hsap\MADD "viable,fertile" FBgn0034010 CG8157 - http://flybase.org/reports/FBgn0034010 protein_coding_gene - - - "BcDNA:RE07473, CG8157" - CG8157 27-Aug-18 DroID_v2018_08 - - Cele\fipr-21 - - - viable FBgn0264909 lncRNA:CR44100 - http://flybase.org/reports/FBgn0264909 non_protein_coding_gene - - - CR44100 - CR44100 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0004359 T48 Transcript 48 http://flybase.org/reports/FBgn0004359 - protein_coding_gene - ventral furrow formation ; GO:0007370 | inferred from mutant phenotype inferred from genetic interaction with cta apical plasma membrane ; GO:0016324 | inferred from direct assay "48, t48, anon-97D, Ubx-t48, CG5507, T48" IPR009030:Growth factor receptor cysteine-rich domain CG5507 27-Aug-18 DroID_v2018_08 - - - - - - "viable,fertile" ventral furrow FBgn0031695 Cyp4ac3 Cyp4ac3 http://flybase.org/reports/FBgn0031695 protein_coding_gene "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ; GO:0016705 | inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972 heme binding ; GO:0020037 | inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401 iron ion binding ; GO:0005506 | inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401" "oxidation-reduction process ; GO:0055114 | inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401, InterPro:IPR017972" - "CG14031, 4ac3, Cyp4ac3" "IPR001128:Cytochrome P450, IPR002401:Cytochrome P450, E-class, group I, IPR017972:Cytochrome P450, conserved site" CG14031 27-Aug-18 DroID_v2018_08 "Drer\cyp3a65, Drer\cyp26c1, Drer\LOC100329425, Drer\cyp4f3, Drer\cyp19a1a, Drer\cyp4v8, Drer\cyp4v7, Drer\cyp46a1.1, Drer\cyp46a1.3, Drer\cyp26b1, Drer\cyp19a1b, Drer\cyp46a1.2, Drer\cyp3c4, Drer\cyp3c3, Drer\cyp26a1, Drer\cyp3c1, Drer\cyp46a1.4, Drer\cyp3c2, Drer\cyp20a1, Drer\cyp4t8" "Scer\ERG5, Scer\DIT2" "Cele\cyp-37B1, Cele\cyp-29A4, Cele\cyp-13A10, Cele\cyp-13A7, Cele\cyp-13A11, Cele\cyp-13A5, Cele\cyp-25A1, Cele\cyp-13A8, Cele\cyp-29A2, Cele\cyp-25A2, Cele\cyp-32A1, Cele\cyp-42A1, Cele\cyp-31A3, Cele\cyp-13A1, Cele\cyp-25A4, Cele\cyp-14A1, Cele\cyp-37A1, Cele\cyp-31A5, Cele\cyp-13A3, Cele\cyp-25A3, Cele\cyp-13A12, Cele\cyp-31A2, Cele\cyp-29A3, Cele\cyp-32B1, Cele\cyp-13A4" "Xtro\cyp26a1, Xtro\cyp4f2, Xtro\cyp20a1, Xtro\cyp4v2, Xtro\cyp26b1, Xtro\LOC100487918, Xtro\LOC100488227, Xtro\cyp4f22, Xtro\mgc108213, Xtro\cyp19a1, Xtro\cyp26c1, Xtro\cyp4b1.2, Xtro\cyp4b1" "Mmus\Cyp4f14, Mmus\Cyp3a57, Mmus\Cyp4a29, Mmus\Cyp20a1, Mmus\Cyp4a30b, Mmus\Cyp19a1, Mmus\Cyp3a59, Mmus\Cyp3a41a, Mmus\Cyp4f18, Mmus\Cyp26b1, Mmus\Cyp3a25, Mmus\Cyp46a1, Mmus\Cyp4a32, Mmus\Cyp26c1, Mmus\Cyp4v3, Mmus\Cyp4f40, Mmus\Cyp4f39, Mmus\Cyp4a14, Mmus\Cyp4b1, Mmus\Cyp4a12a, Mmus\Cyp4x1, Mmus\Cyp4f13, Mmus\Cyp3a41b, Mmus\Cyp3a16, Mmus\Cyp4a31, Mmus\Cyp3a13, Mmus\Cyp4f37, Mmus\Cyp3a44, Mmus\Cyp4f15, Mmus\Cyp26a1, Mmus\Cyp4a12b, Mmus\Cyp4f17, Mmus\Cyp3a11, Mmus\Cyp4f16, Mmus\Cyp4a10" "Hsap\CYP4F2, Hsap\CYP3A43, Hsap\CYP4F12, Hsap\CYP4F22, Hsap\CYP26B1, Hsap\CYP4Z1, Hsap\CYP19A1, Hsap\CYP4A22, Hsap\CYP46A1, Hsap\CYP20A1, Hsap\CYP26C1, Hsap\CYP4F11, Hsap\CYP3A4, Hsap\CYP4B1, Hsap\CYP3A7, Hsap\CYP3A5, Hsap\CYP4X1, Hsap\CYP26A1, Hsap\CYP4A11, Hsap\CYP4V2, Hsap\CYP4F8, Hsap\CYP4F3" "lethal - all die before end of pupal stage,some die during pupal stage,viable" FBgn0025158 ms(2)A1 ms(2)A1 http://flybase.org/reports/FBgn0025158 - gene - - - ms(2)A1 - - 27-Aug-18 DroID_v2018_08 - - - - - - "male sterile,recessive" FBgn0065161 l(3)SH043 lethal (3) SH043 http://flybase.org/reports/FBgn0065161 gene - - - "l(3)SH043, l(2)SH3 043" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0060661 l(3)S082414a lethal (3) S082414a http://flybase.org/reports/FBgn0060661 gene - - - "0824/14, l(3)S082414a" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,partially lethal - majority die,recessive" FBgn0016810 l(1)L11 lethal (1) L11 http://flybase.org/reports/FBgn0016810 - gene - - - "l(1)L11, L11" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0001339 l(1)1Bg lethal (1) 1Bg http://flybase.org/reports/FBgn0001339 - gene - - - "l(1)Bg, l(1)1Bg" - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0051065 ppk31 pickpocket 31 http://flybase.org/reports/FBgn0051065 protein_coding_gene sodium channel activity ; GO:0005272 | inferred from sequence or structural similarity with MGI:MGI:101782 sodium ion transport ; GO:0006814 | inferred from sequence or structural similarity with MGI:MGI:101782 integral component of membrane ; GO:0016021 | inferred from sequence or structural similarity with MGI:MGI:101782 "CG31065, ppk31" "IPR001873:Epithelial sodium channel, IPR017896:4Fe-4S ferredoxin-type, iron-sulphur binding domain" CG31065 27-Aug-18 DroID_v2018_08 "Drer\asic4a, Drer\asic1b, Drer\asic2, Drer\asic1a, Drer\asic1c, Drer\asic4b" - "Cele\acd-1, Cele\del-7, Cele\delm-1, Cele\acd-5, Cele\delm-2, Cele\acd-4, Cele\flr-1, Cele\acd-2" "Xtro\scnn1g, Xtro\scnn1b, Xtro\asic4, Xtro\scnn1a, Xtro\scnn1d, Xtro\asic5, Xtro\asic1" "Mmus\Asic2, Mmus\Scnn1b, Mmus\Asic1, Mmus\Asic5, Mmus\Asic3, Mmus\Scnn1a, Mmus\Asic4, Mmus\Scnn1g" "Hsap\SCNN1D, Hsap\ASIC3, Hsap\ASIC1, Hsap\ASIC2, Hsap\SCNN1B, Hsap\SCNN1G, Hsap\SCNN1A, Hsap\ASIC5, Hsap\ASIC4" "viable,lethal" DRSC13811 I 1.689848384 0.073480041 1.317502813 0.452099998 -0.243868111 0.013649685 FBgn0039799 CG15543 - http://flybase.org/reports/FBgn0039799 protein_coding_gene nucleobase-containing compound kinase activity ; GO:0019205 | inferred from electronic annotation with InterPro:IPR000850 ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR000850 nucleobase-containing compound metabolic process ; GO:0006139 | inferred from electronic annotation with InterPro:IPR000850 - CG15543 "IPR027417:P-loop containing nucleoside triphosphate hydrolase, IPR000850:Adenylate kinase/UMP-CMP kinase" CG15543 27-Aug-18 DroID_v2018_08 "Drer\ak3, Drer\ak4, Drer\ak2, Drer\ak8, Drer\si:ch211-199m3.4, Drer\ak7b, Drer\ak7a" "Scer\ADK2, Scer\ADK1" - "Xtro\ak8, Xtro\ak9, Xtro\ak7, Xtro\ak3, Xtro\ak4, Xtro\ak2" "Mmus\Ak7, Mmus\Ak9, Mmus\Ak8, Mmus\Ak4, Mmus\Ak2, Mmus\Ak3" "Hsap\AK9, Hsap\AK7, Hsap\AK8, Hsap\AK3, Hsap\AK4, Hsap\AK2" viable FBgn0069446 E(br)420 E(br)420 http://flybase.org/reports/FBgn0069446 gene - - - E(br)420 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0029139 P(3)98DF P(3)98DF http://flybase.org/reports/FBgn0029139 gene - - - P(3)98DF - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0267137 lncRNA:CR45577 - http://flybase.org/reports/FBgn0267137 non_protein_coding_gene - - - CR45577 - CR45577 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0060984 l(3)S028218b lethal (3) S028218b http://flybase.org/reports/FBgn0060984 gene - - - "0282/18, l(3)S028218b" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0040246 anon-57Bb anon-57Bb http://flybase.org/reports/FBgn0040246 gene - - - anon-57Bb - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0030307 CG33235 - http://flybase.org/reports/FBgn0030307 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG15192, CG33235" - CG33235 27-Aug-18 DroID_v2018_08 Drer\aim1b - - - - - "viable,partially lethal - majority die,some die during pupal stage" FBgn0015425 l(1)1CDb lethal (1) 1CDb http://flybase.org/reports/FBgn0015425 - gene - - - l(1)1CDb - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0001879 l(1)YD23b lethal (1) YD23b http://flybase.org/reports/FBgn0001879 - gene - - - "l(1)YD23, l(1)YD23b" - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0016053 pgc polar granule component http://flybase.org/reports/FBgn0016053 FBgn0034719 protein_coding_gene - "pole cell migration ; GO:0007280 | inferred from mutant phenotype pole cell development ; GO:0007277 | inferred from mutant phenotype germ cell migration ; GO:0008354 | traceable author statement negative regulation of transcription, DNA-templated ; GO:0045892 | inferred from direct assay germ cell development ; GO:0007281 | inferred from mutant phenotype" P granule ; GO:0043186 | non-traceable author statement pole plasm ; GO:0045495 | traceable author statement pole plasm ; GO:0045495 | inferred from direct assay P granule ; GO:0043186 | traceable author statement P granule ; GO:0043186 | inferred from direct assay "pgc-1, Pgc, pgr, Pgc1, CG11296, CR32885, pgc, CG32885" - CG32885 27-Aug-18 DroID_v2018_08 - - - - - - "viable,body color defective,lethal - all die before end of embryonic stage,some die during embryonic stage" "mesothoracic tergum,pole cell,gonad" DRSC04099 E -1.48869092 0.286435893 3.129323254 0.228627332 0.121689279 -0.579230664 FBgn0265001 ppk18 pickpocket 18 http://flybase.org/reports/FBgn0265001 protein_coding_gene sodium channel activity ; GO:0005272 | inferred from sequence or structural similarity with MGI:MGI:101782 sodium ion transport ; GO:0006814 | inferred from sequence or structural similarity with MGI:MGI:101782 integral component of membrane ; GO:0016021 | inferred from sequence or structural similarity with MGI:MGI:101782 "CG13120, CG13121, ppk18, CG44152" IPR001873:Epithelial sodium channel CG44152 27-Aug-18 DroID_v2018_08 "Drer\asic2, Drer\asic4a, Drer\asic1a, Drer\asic4b, Drer\asic1b, Drer\asic1c" - "Cele\delm-2, Cele\acd-5, Cele\acd-2, Cele\acd-4, Cele\acd-1, Cele\delm-1, Cele\del-7, Cele\flr-1" "Xtro\scnn1b, Xtro\scnn1g, Xtro\asic4, Xtro\asic5, Xtro\scnn1a, Xtro\scnn1d, Xtro\asic1" "Mmus\Scnn1a, Mmus\Asic1, Mmus\Asic4, Mmus\Scnn1b, Mmus\Asic2, Mmus\Asic3, Mmus\Asic5, Mmus\Scnn1g" "Hsap\ASIC1, Hsap\SCNN1G, Hsap\SCNN1B, Hsap\ASIC3, Hsap\ASIC2, Hsap\SCNN1A, Hsap\SCNN1D, Hsap\ASIC4, Hsap\ASIC5" FBgn0058445 CG40445 - http://flybase.org/reports/FBgn0058445 protein_coding_gene - - - CG40445 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0031125 CG11692 - http://flybase.org/reports/FBgn0031125 protein_coding_gene - - - CG11692 - - 27-Aug-18 DroID_v2018_08 - - - - - - DRSC20484 K 0.849424643 -0.142604461 0.044316624 0.13591258 -0.469378822 -1.725126463 FBgn0267499 5.8SrRNA:CR45839 5.8S ribosomal RNA:CR45839 http://flybase.org/reports/FBgn0267499 rRNA_gene - - - "5.8SrRNA:CR45839, CR45839" - CR45839 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0031901 CG13785 - http://flybase.org/reports/FBgn0031901 protein_coding_gene - - - CG13785 - - 27-Aug-18 DroID_v2018_08 - - - - - - DRSC02288 K -0.180250639 -0.230306034 -0.41107337 0.3600402 -1.696993814 -0.554800955 FBgn0026174 SkpD SKP1-related D http://flybase.org/reports/FBgn0026174 "FBgn0031072, FBgn0047345" protein_coding_gene ubiquitin-protein transferase activity ; GO:0004842 | contributes_to inferred from sequence or structural similarity with SGD:S000002736 protein ubiquitination involved in ubiquitin-dependent protein catabolic process ; GO:0042787 | inferred from sequence or structural similarity with SGD:S000002736 SCF ubiquitin ligase complex ; GO:0019005 | inferred from sequence or structural similarity with SGD:S000002736 "CG12700, dskpD, BcDNA:AT18217, Skp, SkpD, skpD" "IPR011333:SKP1/BTB/POZ domain, IPR001232:S-phase kinase-associated protein 1-like, IPR016072:SKP1 component, dimerisation, IPR016073:SKP1 component, POZ domain, IPR016897:S-phase kinase-associated protein 1" CG12700 27-Aug-18 DroID_v2018_08 Drer\skp1 Scer\SKP1 "Cele\skr-18, Cele\skr-20, Cele\skr-15, Cele\skr-5, Cele\skr-9, Cele\skr-7, Cele\skr-1, Cele\skr-10, Cele\skr-14, Cele\skr-13, Cele\skr-12, Cele\skr-21, Cele\skr-6, Cele\skr-16, Cele\skr-2, Cele\skr-3, Cele\skr-4, Cele\skr-19, Cele\skr-17, Cele\skr-8" Xtro\skp1 Mmus\Skp1a Hsap\SKP1 "visible,partially lethal - majority die,some die during pupal stage" mesothoracic tergum FBgn0023135 WppH White prepupal locus H http://flybase.org/reports/FBgn0023135 - gene - - - "9, 36, 22B, WppH" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0050251 tRNA:His-GTG-1-3 transfer RNA:Histidine-GTG 1-3 http://flybase.org/reports/FBgn0050251 tRNA_gene CAC codon-amino acid adaptor activity ; GO:0033426 | inferred from sequence model translation ; GO:0006412 | inferred by curator from GO:0033426 cytosol ; GO:0005829 | inferred by curator from GO:0033426 "AE002787.trna19-HisGTG, tRNA:H:GTG:AE002787-b, CR30251, tRNA[His], chr2R.trna78-HisGTG, tRNA-His-GTG-1-3, tRNA:His-GTG-1-3, tRNA:CR30251, CAC" - CR30251 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0028644 beat-Ic beaten path Ic http://flybase.org/reports/FBgn0028644 protein_coding_gene molecular_function ; GO:0003674 | no biological data available axon guidance ; GO:0007411 | inferred from mutant phenotype defasciculation of motor neuron axon ; GO:0007415 | inferred from genetic interaction with beat-Ia heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules ; GO:0007157 | inferred from genetic interaction with beat-Ia integral component of plasma membrane ; GO:0005887 | inferred from sequence model "beat-C, beat Ic, CT15531, BG:DS00913.1, CG4838, beat-Ic, Beat-Ic" "IPR007110:Immunoglobulin-like domain, IPR013162:CD80-like, immunoglobulin C2-set, IPR013783:Immunoglobulin-like fold" CG4838 27-Aug-18 DroID_v2018_08 "Drer\f11r.2, Drer\jam2b" - - - - "Hsap\CADM2, Hsap\F11R" "lethal,lethal - all die before end of pupal stage,some die during pupal stage" "intersegmental nerve,transverse nerve,RP3 motor neuron,RP1 motor neuron" DRSC03491 I -0.689103294 -1.766771426 -1.232159393 -0.915894067 0.44087451 -0.574603779 FBgn0264829 CG44037 - http://flybase.org/reports/FBgn0264829 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG44037 - CG44037 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0067096 H84 H84 http://flybase.org/reports/FBgn0067096 gene - - - H84 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,viable" FBgn0260436 CG42531 - http://flybase.org/reports/FBgn0260436 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG42531 - CG42531 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0067810 anon-N1 anon-N1 http://flybase.org/reports/FBgn0067810 gene - - - "N1, anon-N1" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0062978 CG31808 - http://flybase.org/reports/FBgn0062978 protein_coding_gene - - - "CG31808, RE70695, BcDNA:RE70695, MRE33, CR31808" - CG31808 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0000915 fs(1)ne1 female sterile (1) no eggs 1 http://flybase.org/reports/FBgn0000915 - gene - - - "ne1, fs(1)ne[1], fs(1)ne1" - - 27-Aug-18 DroID_v2018_08 - - - - - - "female sterile,recessive,female sterile soma-dependent" "oocyte,endochorion,stage S10A oocyte,stage S10B oocyte,dorsal appendage,chorion" FBgn0036768 CG7402 - http://flybase.org/reports/FBgn0036768 protein_coding_gene sulfuric ester hydrolase activity ; GO:0008484 | inferred from electronic annotation with InterPro:IPR000917 "metabolic process ; GO:0008152 | inferred from electronic annotation with InterPro:IPR000917, InterPro:IPR017849, InterPro:IPR017850" - CG7402 "IPR000917:Sulfatase, N-terminal, IPR017849:Alkaline phosphatase-like, alpha/beta/alpha, IPR017850:Alkaline-phosphatase-like, core domain, IPR024607:Sulfatase, conserved site" CG7402 27-Aug-18 DroID_v2018_08 "Drer\arsb, Drer\arsia, Drer\ids, Drer\sgsh, Drer\galns, Drer\LOC563783, Drer\LOC101884179, Drer\arsh, Drer\LOC559800, Drer\arsa, Drer\si:dkey-174i8.1, Drer\arsg" - Cele\sul-3 "Xtro\arsb, Xtro\arsd, Xtro\arsi, Xtro\arsj, Xtro\arsa.1, Xtro\arsk, Xtro\sgsh, Xtro\arsh, Xtro\ids, Xtro\sts" "Mmus\Arsj, Mmus\Sgsh, Mmus\Arsi, Mmus\Arsa, Mmus\Arsg, Mmus\Arsb, Mmus\Ids, Mmus\Galns" "Hsap\STS, Hsap\ARSF, Hsap\GALNS, Hsap\SGSH, Hsap\ARSG, Hsap\IDS, Hsap\ARSB, Hsap\ARSJ, Hsap\ARSE, Hsap\ARSA, Hsap\ARSI, Hsap\ARSD, Hsap\ARSH" "viable,fertile" FBgn0259255 EP-469.2 - http://flybase.org/reports/FBgn0259255 gene - - - EP-469.2 - - 27-Aug-18 DroID_v2018_08 - - - - - - visible "wing vein,wing margin,chaeta,ectopic" FBgn0051602 tRNA:Asp-GTC-1-6 transfer RNA:Aspartic acid-GTC 1-6 http://flybase.org/reports/FBgn0051602 tRNA_gene GAC codon-amino acid adaptor activity ; GO:0033458 | inferred from sequence model translation ; GO:0006412 | inferred by curator from GO:0033458 cytosol ; GO:0005829 | inferred by curator from GO:0033458 "Asp-tRNA, AE002690.trna6-AspGTC, tRNA:asp2:29E, tRNA:D2:29E, tRNA:D:GTC:AE002690-b, CR31602, tRNA[[Asp]], tRNA[Asp-GTC], chr2L.trna15-AspGTC, tRNA:Asp-GTC-1-6, tRNA:CR31602, tRNA-Asp-GTC-1-6, GAC" - CR31602 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0005217 l(3)ET8 lethal Elaine Tasaka 8 http://flybase.org/reports/FBgn0005217 - gene - - - l(3)ET8 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,heat sensitive,male sterile" FBgn0083017 snoRNA:Psi18S-841c snoRNA:Psi18S-841c http://flybase.org/reports/FBgn0083017 snoRNA_gene - - - "snoRNA:Psi18S-841c, Psi18S-841c, psi18S-841c, CR34553, chr2R:16838224..16838314" - CR34553 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0000651 febB feeding behavior B http://flybase.org/reports/FBgn0000651 - gene - - - febB - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,behavior defective,recessive,feeding behavior defective,somatic clone" FBgn0031826 CG9550 - http://flybase.org/reports/FBgn0031826 protein_coding_gene N-acetylglucosamine 6-O-sulfotransferase activity ; GO:0001517 | inferred from biological aspect of ancestor with PANTHER:PTN000842280 sulfur compound metabolic process ; GO:0006790 | inferred from biological aspect of ancestor with PANTHER:PTN001322541 integral component of membrane ; GO:0016021 | inferred from biological aspect of ancestor with PANTHER:PTN001322541 "CG9550, d6ST2" "IPR027417:P-loop containing nucleoside triphosphate hydrolase, IPR000863:Sulfotransferase domain" CG9550 27-Aug-18 DroID_v2018_08 "Drer\zgc:194879, Drer\chst2b, Drer\chst3b, Drer\chst2a, Drer\chst1, Drer\chst7, Drer\chst3a, Drer\si:ch73-62b13.1" - - "Xtro\chst1, Xtro\chst4, Xtro\chst2, Xtro\chst7, Xtro\chst6, Xtro\chst3" "Mmus\Chst5, Mmus\Chst7, Mmus\Chst1, Mmus\Chst4, Mmus\Chst3, Mmus\Chst2" "Hsap\CHST7, Hsap\CHST4, Hsap\CHST1, Hsap\CHST3, Hsap\CHST5, Hsap\CHST6, Hsap\CHST2" viable FBgn0030777 CG9672 - http://flybase.org/reports/FBgn0030777 protein_coding_gene serine-type endopeptidase activity ; GO:0004252 | NOT inferred from key residues "proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314" extracellular space ; GO:0005615 | inferred from biological aspect of ancestor with PANTHER:PTN000669108 "SPH161, BcDNA:GH16384, CG9672" "IPR001254:Serine proteases, trypsin domain, IPR001314:Peptidase S1A, chymotrypsin family, IPR009003:Peptidase S1, PA clan" CG9672 27-Aug-18 DroID_v2018_08 "Drer\proca, Drer\si:ch211-165b19.9, Drer\si:dkey-21e2.3, Drer\gzm3, Drer\proza, Drer\gzma, Drer\LOC558805, Drer\si:dkey-21e2.16, Drer\zgc:171509, Drer\zgc:163025, Drer\si:ch211-165b19.8, Drer\prozb, Drer\gzmk" - - - "Mmus\Klk12, Mmus\Proc, Mmus\Proz" "Hsap\PROC, Hsap\PROZ" viable FBgn0011167 l(1)DM-4 lethal (1) DM-4 http://flybase.org/reports/FBgn0011167 FBgn0010204 gene - - - l(1)DM-4 - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0003243 rfr refringent http://flybase.org/reports/FBgn0003243 - gene - oogenesis ; GO:0048477 | traceable author statement - "ref, rfr" - - 27-Aug-18 DroID_v2018_08 - - - - - - "female sterile,recessive,visible,viable,male,male fertile,female,reduced" wing FBgn0034942 CG13566 - http://flybase.org/reports/FBgn0034942 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG13566 - CG13566 27-Aug-18 DroID_v2018_08 - - - - - - viable DRSC04203 I -1.617712005 -1.058909333 -0.100310023 0.839259811 0.769476694 0.777256016 FBgn0026873 MED18 Mediator complex subunit 18 http://flybase.org/reports/FBgn0026873 - protein_coding_gene RNA polymerase II transcription cofactor activity ; GO:0001104 | contributes_to inferred by curator from GO:0016592 RNA polymerase II transcription cofactor activity ; GO:0001104 | inferred from mutant phenotype protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q8MSX2 regulation of transcription from RNA polymerase II promoter ; GO:0006357 | inferred from electronic annotation with InterPro:IPR019095 regulation of transcription from RNA polymerase II promoter ; GO:0006357 | inferred by curator from GO:0016592 transcription from RNA polymerase II promoter ; GO:0006366 | inferred from mutant phenotype termination of RNA polymerase II transcription ; GO:0006369 | inferred from biological aspect of ancestor with PANTHER:PTN001410513 core mediator complex ; GO:0070847 | inferred from biological aspect of ancestor with PANTHER:PTN001410513 nucleus ; GO:0005634 | inferred from direct assay mediator complex ; GO:0016592 | inferred from direct assay "CG14802, Med18, p28/CG14802, Srb5/Med28b, dp28b, EG:63B12.13, p28, MED18" "IPR019095:Mediator complex, subunit Med18, metazoa/fungi" CG14802 27-Aug-18 DroID_v2018_08 Drer\med18 Scer\SRB5 Cele\mdt-18 Xtro\med18 Mmus\Med18 Hsap\MED18 "cell growth defective,visible,partially lethal - majority die,some die during pupal stage" "trichogen cell,chaeta,supernumerary" FBgn0020566 anon-88Ad anon-88Ad http://flybase.org/reports/FBgn0020566 - gene - - - anon-88Ad - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0001521 l(1)11Ae lethal (1) 11Ae http://flybase.org/reports/FBgn0001521 - gene - - - "l(1)L2, 2, l(1)11Ae" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0259990 CG42487 - http://flybase.org/reports/FBgn0259990 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG42487 - CG42487 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0030871 CG8142 - http://flybase.org/reports/FBgn0030871 protein_coding_gene ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR003959 DNA clamp loader activity ; GO:0003689 | contributes_to inferred from biological aspect of ancestor with PANTHER:PTN000186208 cytoplasmic microtubule organization ; GO:0031122 | inferred from mutant phenotype lateral inhibition ; GO:0046331 | inferred from mutant phenotype DNA-dependent DNA replication ; GO:0006261 | inferred from biological aspect of ancestor with PANTHER:PTN000186208 Elg1 RFC-like complex ; GO:0031391 | inferred from direct assay DNA replication factor C complex ; GO:0005663 | inferred from biological aspect of ancestor with PANTHER:PTN000186208 microtubule associated complex ; GO:0005875 | inferred from direct assay "CG8142, RfC, DmRFC2, RFC2, Rfc37" "IPR003593:AAA+ ATPase domain, IPR003959:ATPase, AAA-type, core, IPR008921:DNA polymerase III, clamp loader complex, gamma/delta/delta subunit, C-terminal, IPR013748:Replication factor C, C-terminal, IPR027417:P-loop containing nucleoside triphosphate hydrolase" CG8142 27-Aug-18 DroID_v2018_08 "Drer\rfc4, Drer\rfc2, Drer\rfc5" Scer\RFC2 "Cele\rfc-2, Cele\F44B9.8, Cele\rfc-4" "Xtro\rfc2, Xtro\rfc5, Xtro\rfc4" "Mmus\Rfc2, Mmus\Rfc5, Mmus\Rfc4" "Hsap\RFC2, Hsap\RFC4, Hsap\RFC5" "viable,fertile,visible" "chaeta,trichogen cell" FBgn0003977 vir virilizer http://flybase.org/reports/FBgn0003977 FBgn0034852 protein_coding_gene nucleic acid binding ; GO:0003676 | inferred from sequence or structural similarity with protein_id:AAC03114.1 inferred from sequence or structural similarity with protein_id:CAA53660.1 protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q9Y091 "regulation of alternative mRNA splicing, via spliceosome ; GO:0000381 | inferred from mutant phenotype border follicle cell migration ; GO:0007298 | inferred from mutant phenotype primary sex determination, soma ; GO:0007539 | non-traceable author statement sex determination ; GO:0007530 | traceable author statement RNA splicing, via transesterification reactions ; GO:0000375 | inferred from mutant phenotype regulation of mRNA splicing, via spliceosome ; GO:0048024 | traceable author statement dosage compensation ; GO:0007549 | traceable author statement" integral component of membrane ; GO:0016021 | inferred from sequence or structural similarity nucleus ; GO:0005634 | inferred from sequence or structural similarity inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay "CG3496, vir, Vir" "IPR026736:Protein virilizer, IPR031801:Virilizer, N-terminal" CG3496 27-Aug-18 DroID_v2018_08 Drer\si:ch211-79l20.4 - - Xtro\kiaa1429 Mmus\1110037F02Rik Hsap\KIAA1429 "lethal,recessive,wild-type,sex-determination defective,female,heat sensitive,viable,lethal - all die before end of larval stage,some die during larval stage,female sterile,maternal effect,male,male fertile,partially lethal - majority die,visible" "border follicle cell,somatic clone,adult abdomen,heat sensitive,abdominal tergite 6,abdominal tergite 7,oviprotector,female gonopod,anal plate,hypoproct,chaeta,supernumerary,trichogen cell,mesothoracic tergum" FBgn0262636 dati datilografo http://flybase.org/reports/FBgn0262636 protein_coding_gene nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR013087 neuron projection development ; GO:0031175 | inferred from mutant phenotype generation of neurons ; GO:0048699 | inferred from mutant phenotype adult locomotory behavior ; GO:0008344 | inferred from mutant phenotype mushroom body development ; GO:0016319 | inferred from mutant phenotype positive regulation of female receptivity ; GO:0045925 | inferred from mutant phenotype - "CG2052, dati, CG10204, DmLin29, Lin29" IPR013087:Zinc finger C2H2-type CG2052 27-Aug-18 DroID_v2018_08 "Drer\si:dkeyp-121d2.7, Drer\si: zfos-932h1.3, Drer\LOC100534979, Drer\znf1174, Drer\znf362b, Drer\znf362a" Scer\AZF1 Cele\lin-29 "Xtro\zxdc, Xtro\znf362" "Mmus\Zxdc, Mmus\Zxdb, Mmus\Zfp236, Mmus\Zfp217, Mmus\Zfp362" "Hsap\ZBTB48, Hsap\ZXDB, Hsap\ZNF362, Hsap\ZXDA, Hsap\ZXDC" FBgn0264489 CG43897 - http://flybase.org/reports/FBgn0264489 protein_coding_gene structural constituent of ribosome ; GO:0003735 | inferred from electronic annotation with InterPro:IPR005822 translation ; GO:0006412 | inferred from electronic annotation with InterPro:IPR005822 lateral inhibition ; GO:0046331 | inferred from mutant phenotype mesoderm development ; GO:0007498 | inferred from expression pattern ribosome ; GO:0005840 | inferred from electronic annotation with InterPro:IPR005822 "CG43897, CG33205, CG32050, CG8154, CG8163, CG14172, CG32051, CG32049, BcDNA:RH19933, BcDNA:RE55923" "IPR005822:Ribosomal protein L13, IPR006643:Zasp-like motif, IPR031847:Domain of unknown function DUF4749" CG43897 27-Aug-18 DroID_v2018_08 "Drer\pdlim1, Drer\pdlim3b, Drer\pdlim2, Drer\pdlim4, Drer\pdlim3a" - - - "Mmus\Pdlim2, Mmus\Pdlim3, Mmus\Pdlim4, Mmus\Prickle4, Mmus\Pdlim1" "Hsap\BRD4, Hsap\PDLIM1, Hsap\PRICKLE4, Hsap\PDLIM3, Hsap\PDLIM2, Hsap\PDLIM4" FBgn0265778 PDZ-GEF PDZ domain-containing guanine nucleotide exchange factor http://flybase.org/reports/FBgn0265778 protein_coding_gene Rap guanyl-nucleotide exchange factor activity ; GO:0017034 | inferred from sequence or structural similarity with HGNC:16854 Ras GTPase binding ; GO:0017016 | inferred from physical interaction with Rap1 Rap guanyl-nucleotide exchange factor activity ; GO:0017034 | inferred from direct assay "small GTPase mediated signal transduction ; GO:0007264 | inferred from electronic annotation with InterPro:IPR001895, InterPro:IPR019804 oogenesis ; GO:0048477 | inferred from mutant phenotype germ-line stem cell population maintenance ; GO:0030718 | inferred from mutant phenotype MAPK cascade ; GO:0000165 | inferred from genetic interaction with Raf inferred from genetic interaction with rl inferred from genetic interaction with Dsor1 adherens junction assembly ; GO:0034333 | inferred from genetic interaction with Rap1 hemocyte migration ; GO:0035099 | inferred from mutant phenotype substrate-dependent cell migration, cell extension ; GO:0006930 | inferred from mutant phenotype compound eye development ; GO:0048749 | inferred from mutant phenotype imaginal disc-derived male genitalia development ; GO:0007485 | inferred from mutant phenotype imaginal disc-derived wing morphogenesis ; GO:0007476 | inferred from mutant phenotype regulation of embryonic cell shape ; GO:0016476 | inferred from mutant phenotype positive regulation of GTPase activity ; GO:0043547 | inferred from sequence or structural similarity with HGNC:16854 regulation of compound eye photoreceptor development ; GO:0045314 | inferred from mutant phenotype dorsal closure ; GO:0007391 | inferred from mutant phenotype inferred from genetic interaction with Rap1, cno, zip" apicolateral plasma membrane ; GO:0016327 | inferred from direct assay adherens junction ; GO:0005912 | colocalizes_with inferred from direct assay "EC2-8, Gef26, PDZ-GEF, dizzy, CG9491, dzy, dPDZ-GEF, PDF-GEF Dizzy, l(2)k13720, GEF, D-PDZGEF, DGEF, Dzy" "IPR029071:Ubiquitin-related domain, IPR023578:Ras guanine nucleotide exchange factor domain, IPR019804:Ras guanine-nucleotide exchange factor, conserved site, IPR014710:RmlC-like jelly roll fold, IPR001895:Ras guanine-nucleotide exchange factors catalytic domain, IPR001478:PDZ domain, IPR000651:Ras-like guanine nucleotide exchange factor, N-terminal, IPR000595:Cyclic nucleotide-binding domain, IPR000159:Ras-associating (RA) domain, IPR018490:Cyclic nucleotide-binding-like" CG9491 27-Aug-18 DroID_v2018_08 "Drer\rasgrf2b, Drer\si:ch211-234p18.3, Drer\rapgef1a, Drer\sos1, Drer\si:dkey-253i9.4, Drer\rapgef1b, Drer\rapgef6, Drer\rapgef2" "Scer\LTE1, Scer\CDC25" "Cele\Y34B4A.4, Cele\pxf-1, Cele\sos-1" - "Mmus\Rasgrf1, Mmus\Rapgef1, Mmus\Rapgef6, Mmus\Rasgrf2, Mmus\Rapgef2, Mmus\Sos1, Mmus\Sos2" "Hsap\RAPGEF6, Hsap\RASGRF1, Hsap\RASGRF2, Hsap\SOS2, Hsap\RAPGEF2, Hsap\SOS1, Hsap\RAPGEF1" DRSC03231 E -1.115914075 -0.531928597 -1.770098189 -0.470963788 1.111480823 -0.889726447 FBgn0052576 CG32576 - http://flybase.org/reports/FBgn0052576 protein_coding_gene molecular_function ; GO:0003674 | no biological data available vesicle-mediated transport ; GO:0016192 | inferred from electronic annotation with InterPro:IPR007305 cellular_component ; GO:0005575 | no biological data available "NEST:bs01h05, anon-AE003501.1, BcDNA:RE29988, CG32576" "IPR007305:Vesicle transport protein, Got1/SFT2-like" CG32576 27-Aug-18 DroID_v2018_08 "Drer\golt1bb, Drer\golt1a, Drer\golt1ba" Scer\GOT1 Cele\F41C3.4 Xtro\golt1b "Mmus\Golt1b, Mmus\Golt1a" "Hsap\GOLT1B, Hsap\GOLT1A" DRSC19136 K 0.084884855 0.342205001 0.130742592 -0.608990982 0.120520048 1.589680424 FBgn0033104 CG15237 - http://flybase.org/reports/FBgn0033104 protein_coding_gene - regulation of mitotic cell cycle spindle assembly checkpoint ; GO:0090266 | inferred from electronic annotation with InterPro:IPR026182 anaphase-promoting complex ; GO:0005680 | inferred from electronic annotation with InterPro:IPR026182 "CG15237, APC15" IPR026182:Anaphase-promoting complex subunit 15 CG15237 27-Aug-18 DroID_v2018_08 Drer\anapc15 - - - Mmus\Anapc15 Hsap\ANAPC15 viable FBgn0040630 CG12710 - http://flybase.org/reports/FBgn0040630 protein_coding_gene - - - CG12710 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0052029 Cpr66D Cuticular protein 66D http://flybase.org/reports/FBgn0052029 protein_coding_gene structural constituent of cuticle ; GO:0042302 | inferred from electronic annotation with InterPro:IPR000618 structural constituent of chitin-based larval cuticle ; GO:0008010 | inferred from sequence model chitin-based cuticle development ; GO:0040003 | inferred from sequence model extracellular matrix ; GO:0031012 | inferred from sequence model "CG6458, CG6469, Cpr66D, CG32029, DmelCpr66D" "IPR000618:Insect cuticle protein, IPR031311:Chitin-binding type R&R consensus" CG32029 27-Aug-18 DroID_v2018_08 - - Cele\fbxb-38 - - - "viable,fertile" FBgn0040336 Seipin Seipin http://flybase.org/reports/FBgn0040336 protein_coding_gene molecular_function ; GO:0003674 | no biological data available response to starvation ; GO:0042594 | inferred from mutant phenotype fatty acid beta-oxidation ; GO:0006635 | inferred from mutant phenotype regulation of lipid biosynthetic process ; GO:0046890 | inferred from mutant phenotype inferred from genetic interaction with mdy inferred from genetic interaction with mino inferred from genetic interaction with SCAP regulation of triglyceride metabolic process ; GO:0090207 | inferred from mutant phenotype lipid biosynthetic process ; GO:0008610 | inferred from mutant phenotype positive regulation of lipid storage ; GO:0010884 | inferred from mutant phenotype endoplasmic reticulum calcium ion homeostasis ; GO:0032469 | inferred from mutant phenotype regulation of lipid storage ; GO:0010883 | inferred from mutant phenotype phosphatidic acid metabolic process ; GO:0046473 | inferred from mutant phenotype diacylglycerol metabolic process ; GO:0046339 | inferred from mutant phenotype endoplasmic reticulum ; GO:0005783 | inferred from direct assay "EG:BACR7C10.1, CG9904, Seipin, dSeipin" IPR009617:Seipin family CG9904 27-Aug-18 DroID_v2018_08 "Drer\bscl2l, Drer\bscl2" - Cele\R01B10.6 Xtro\bscl2 Mmus\Bscl2 Hsap\BSCL2 "decreased cell size,somatic clone,viable,fertile,lethal,nutrition conditional" "adult fat body,somatic clone,lipid particle | somatic clone,embryonic/larval fat body,nutrition conditional,fat body,salivary gland,lipid particle | ectopic,lipid particle,lipid particle | ectopicppl.PP,lipid particleppl.PP,lipid particle | ectopicelav.PU,lipid particle | ectopic48Y" FBgn0019731 l(1)A17 lethal (1) A17 http://flybase.org/reports/FBgn0019731 - gene - - - l(1)A17 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0028086 l(3)S084805 lethal (3) S084805 http://flybase.org/reports/FBgn0028086 gene - - - "0848/05, l(3)S084805" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0283680 IP3K2 "Inositol 1,4,5-triphosphate kinase 2" http://flybase.org/reports/FBgn0283680 protein_coding_gene "calcium-dependent protein binding ; GO:0048306 | inferred from direct assay calmodulin binding ; GO:0005516 | inferred from direct assay inositol-1,4,5-trisphosphate 3-kinase activity ; GO:0008440 | inferred from direct assay" salivary gland cell autophagic cell death ; GO:0035071 | inferred from mutant phenotype inferred from genetic interaction with mir-14 inositol phosphate biosynthetic process ; GO:0032958 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay "wy, IP3K2, CG15745, ip3k2, CG45017, dmIP[[3]]beta, CG1630, IP[[3]]K2, CG34359, dmIP3Kbeta, dmIP3K2, DIP3K2, D-IP3K2, CG12724, NP2758, IP[[3]]K-2, CG4501" "IPR005522:Inositol polyphosphate kinase, IPR011989:Armadillo-like helical" CG45017 27-Aug-18 DroID_v2018_08 "Drer\itpka, Drer\itpkcb, Drer\itpkb, Drer\itpkca, Drer\si:ch73-22a13.3" - Cele\lfe-2 "Xtro\itpkb, Xtro\itpka, Xtro\itpkc" "Mmus\Itpkb, Mmus\Itpka, Mmus\Itpkc" "Hsap\ITPKB, Hsap\ITPKA, Hsap\ITPKC" "visible,viable,fertile,lethal,male" "wing,abdomen,wing vein L1" FBgn0066330 rafl rafael http://flybase.org/reports/FBgn0066330 gene molecular_function ; GO:0003674 | no biological data available learning or memory ; GO:0007611 | inferred from mutant phenotype olfactory learning ; GO:0008355 | inferred from mutant phenotype visual learning ; GO:0008542 | inferred from mutant phenotype visual behavior ; GO:0007632 | inferred from mutant phenotype behavioral response to ethanol ; GO:0048149 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available rafl - - 27-Aug-18 DroID_v2018_08 - - - - - - "memory defective,visual behavior defective,recessive,learning defective,neurophysiology defective,chemical sensitive" FBgn0050042 Cpr49Ab Cuticular protein 49Ab http://flybase.org/reports/FBgn0050042 protein_coding_gene structural constituent of cuticle ; GO:0042302 | inferred from biological aspect of ancestor with PANTHER:PTN000822475 structural constituent of chitin-based larval cuticle ; GO:0008010 | inferred from sequence model chitin-based cuticle development ; GO:0040003 | inferred from sequence model extracellular matrix ; GO:0031012 | inferred from sequence model "CG8496, Cpr49Ab, CG30042, DmelCpr49Ab" "IPR000618:Insect cuticle protein, IPR031311:Chitin-binding type R&R consensus" CG30042 27-Aug-18 DroID_v2018_08 Drer\LOC100003040 - "Cele\F44F1.4, Cele\sdz-30, Cele\math-34" - "Mmus\2410137M14Rik, Mmus\H2-K1" - viable FBgn0040132 l(2)22Ag lethal (2) 22Ag http://flybase.org/reports/FBgn0040132 gene - - - "A, l(2)22Ag" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0037382 Hpr1 Hpr1 http://flybase.org/reports/FBgn0037382 protein_coding_gene - signal transduction ; GO:0007165 | inferred from electronic annotation with InterPro:IPR000488 mRNA export from nucleus in response to heat stress ; GO:0031990 | inferred from mutant phenotype "protein complex ; GO:0043234 | inferred from physical interaction with thoc5, thoc7 THO complex ; GO:0000347 | inferred from direct assay transcription export complex ; GO:0000346 | inferred from sequence or structural similarity with HGNC:19070 nucleus ; GO:0005634 | inferred from direct assay" "CG2031, Hpr1, HPR1, Thoc1" "IPR000488:Death domain, IPR011029:Death-like domain, IPR021861:THO complex, subunit THOC1" CG2031 27-Aug-18 DroID_v2018_08 "Drer\thoc1, Drer\si:dkeyp-97b10.3, Drer\LOC103911624" - Cele\thoc-1 Xtro\thoc1 Mmus\Thoc1 Hsap\THOC1 viable DRSC12296 I 1.628419054 0.724526984 -0.937161093 -0.094311899 0.863421026 0.11575848 FBgn0267291 lncRNA:CR45727 - http://flybase.org/reports/FBgn0267291 non_protein_coding_gene - spermatogenesis ; GO:0007283 | inferred from mutant phenotype - CR45727 - CR45727 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0015727 Est-F Est-F http://flybase.org/reports/FBgn0015727 - gene - - - "Est-Fs, Est-F" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0046668 anon-38C.29 anon-38C.29 http://flybase.org/reports/FBgn0046668 gene - - - "38C.29, anon-38C.29" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0014314 l(3)ry114 lethal (3) ry114 http://flybase.org/reports/FBgn0014314 - gene - - - l(3)ry114 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0065325 l(2)SH1898 lethal (2) SH1898 http://flybase.org/reports/FBgn0065325 gene - - - "l(2)SH1898, l(2)SH2 1898" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0031626 CG15631 - http://flybase.org/reports/FBgn0031626 protein_coding_gene - - - CG15631 - CG15631 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0261553 CG42671 - http://flybase.org/reports/FBgn0261553 protein_coding_gene - - - "CG42671, CG18490, CG34240" - CG42671 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0065507 l(2)SH1185 lethal (2) SH1185 http://flybase.org/reports/FBgn0065507 gene - - - l(2)SH1185 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0040993 CG17325 - http://flybase.org/reports/FBgn0040993 protein_coding_gene - - - "BcDNA:RH02271, CG17325, Dromel_CG17325_FBtr0081102_mORF" - CG17325 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0263314 CG43400 - http://flybase.org/reports/FBgn0263314 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG43400, lincRNA.75" - CG43400 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0030395 Mks1 "Meckel syndrome, type 1" http://flybase.org/reports/FBgn0030395 protein_coding_gene - ciliary transition zone assembly ; GO:1905349 | inferred from mutant phenotype axoneme assembly ; GO:0035082 | inferred from mutant phenotype non-motile cilium assembly ; GO:1905515 | inferred from mutant phenotype regulation of establishment of planar polarity ; GO:0090175 | inferred from mutant phenotype ciliary transition zone ; GO:0035869 | inferred from direct assay MKS complex ; GO:0036038 | inferred from sequence or structural similarity with MGI:MGI:3584243 "CG15730, Mks1, dMks1" IPR010796:B9 domain CG15730 27-Aug-18 DroID_v2018_08 Drer\mks1 - Cele\mks-1 Xtro\mks1 Mmus\Mks1 Hsap\MKS1 "viable,planar polarity defective,visible" "ommatidium,wing hair,supernumerary,wing blade" FBgn0053094 Synd Syndapin http://flybase.org/reports/FBgn0053094 protein_coding_gene protein binding ; GO:0005515 | inferred from physical interaction with scra phospholipid binding ; GO:0005543 | inferred from sequence model lipid binding ; GO:0008289 | inferred from direct assay synaptic vesicle endocytosis ; GO:0048488 | non-traceable author statement membrane organization ; GO:0061024 | inferred from direct assay positive regulation of synaptic growth at neuromuscular junction ; GO:0045887 | inferred from mutant phenotype cleavage furrow ingression ; GO:0036090 | inferred from mutant phenotype male meiosis cytokinesis ; GO:0007112 | inferred from mutant phenotype spindle assembly involved in male meiosis ; GO:0007053 | inferred from mutant phenotype neurotransmitter secretion ; GO:0007269 | non-traceable author statement mitotic cytokinesis ; GO:0000281 | inferred from mutant phenotype regulation of endocytosis ; GO:0030100 | inferred from biological aspect of ancestor with PANTHER:PTN000860688 postsynaptic membrane ; GO:0045211 | inferred from direct assay subsynaptic reticulum ; GO:0071212 | inferred from direct assay plasma membrane ; GO:0005886 | inferred from direct assay endosome ; GO:0005768 | inferred from biological aspect of ancestor with PANTHER:PTN000860688 cleavage furrow ; GO:0032154 | inferred from direct assay midbody ; GO:0030496 | inferred from direct assay "CG15694, D-Synd, CG33094, Synd, synd" "IPR001060:FCH domain, IPR001452:SH3 domain, IPR027267:Arfaptin homology (AH) domain/BAR domain, IPR031160:F-BAR domain" CG33094 27-Aug-18 DroID_v2018_08 "Drer\pacsin1a, Drer\si:ch211-51c14.1, Drer\zgc:91999, Drer\arfgap2, Drer\trip10a, Drer\itsn1, Drer\itsn2b, Drer\arfgap3, Drer\pacsin3, Drer\sh3d19, Drer\pacsin2, Drer\itsn2a, Drer\pacsin1b" "Scer\BZZ1, Scer\LSB3, Scer\HOF1, Scer\LSB1, Scer\YSC84, Scer\SYP1" "Cele\B0303.7, Cele\itsn-1, Cele\F07F6.4, Cele\sdpn-1, Cele\toca-1" "Xtro\pacsin2, Xtro\MGC147475, Xtro\pacsin1, Xtro\pacsin3, Xtro\fnbp1l, Xtro\arfgap2" "Mmus\Sh3d19, Mmus\Pacsin2, Mmus\Arfgap2, Mmus\Sh3yl1, Mmus\Itsn1, Mmus\Pacsin1, Mmus\Fnbp1, Mmus\Pacsin3, Mmus\Arfgap3, Mmus\Trip10, Mmus\Fnbp1l, Mmus\Itsn2" "Hsap\SH3D19, Hsap\ARFGAP3, Hsap\ITSN2, Hsap\SH3YL1, Hsap\PACSIN1, Hsap\ARFGAP2, Hsap\PACSIN2, Hsap\ITSN1, Hsap\PACSIN3, Hsap\FNBP1L, Hsap\FNBP1, Hsap\FCHSD1, Hsap\GRAP2, Hsap\TRIP10" "lethal - all die before end of pupal stage,some die during pupal stage,viable,majority die during third instar larval stage,cytokinesis defective,meiotic cell cycle defective,body color defective" "subsynaptic reticulum | third instar larval stageMef2.PR,postsynaptic membrane | third instar larval stageMef2.PR,subsynaptic reticulum | third instar larval stagetub.PU,onion stage spermatid,spermatocyte,spindle midzoneBSC43),contractile ringBSC43),cleavage furrowBSC43),meiotic spindleBSC43),mesothoracic tergum" FBgn0259403 C747 - http://flybase.org/reports/FBgn0259403 gene - - - C747 - - 27-Aug-18 DroID_v2018_08 - - - - - - visible wing vein FBgn0060582 l(3)S094615b lethal (3) S094615b http://flybase.org/reports/FBgn0060582 gene - - - "0946/15, l(3)S094615b" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0083236 EP364 EP364 http://flybase.org/reports/FBgn0083236 gene - - - EP364 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0039387 MCO3 multicopper oxidase 3 http://flybase.org/reports/FBgn0039387 protein_coding_gene "copper ion binding ; GO:0005507 | inferred from electronic annotation with InterPro:IPR002355, InterPro:IPR011706, InterPro:IPR011707 iron ion transmembrane transporter activity ; GO:0005381 | contributes_to inferred from biological aspect of ancestor with PANTHER:PTN001709969 ferroxidase activity ; GO:0004322 | inferred from biological aspect of ancestor with PANTHER:PTN001709969" "oxidation-reduction process ; GO:0055114 | inferred from electronic annotation with InterPro:IPR001117, InterPro:IPR011706 iron ion transport ; GO:0006826 | inferred from biological aspect of ancestor with PANTHER:PTN001709969 iron assimilation by reduction and transport ; GO:0033215 | inferred from biological aspect of ancestor with PANTHER:PTN001709969 copper ion homeostasis ; GO:0055070 | inferred from direct assay" high-affinity iron permease complex ; GO:0033573 | inferred from biological aspect of ancestor with PANTHER:PTN001709969 "MCO3, CG5959, MIP26036" "IPR001117:Multicopper oxidase, type 1, IPR002355:Multicopper oxidase, copper-binding site, IPR008972:Cupredoxin, IPR011706:Multicopper oxidase, type 2, IPR011707:Multicopper oxidase, type 3, IPR033138:Multicopper oxidases, conserved site" CG5959 27-Aug-18 DroID_v2018_08 "Drer\cp, Drer\hephl1b" "Scer\GMC1, Scer\FET3, Scer\FET5" Cele\F21D5.3 Xtro\hephl1 "Mmus\Heph, Mmus\Hephl1, Mmus\Cp" "Hsap\CP, Hsap\HEPHL1, Hsap\HEPH" "viable,fertile" FBgn0262103 Sik3 Salt-inducible kinase 3 http://flybase.org/reports/FBgn0262103 protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR017441 protein serine/threonine kinase activity ; GO:0004674 | inferred from sequence or structural similarity with HGNC:21680 protein serine/threonine kinase activity ; GO:0004674 | inferred from biological aspect of ancestor with PANTHER:PTN000678822 protein serine/threonine kinase activity ; GO:0004674 | non-traceable author statement" protein phosphorylation ; GO:0006468 | inferred from biological aspect of ancestor with PANTHER:PTN000678822 regulation of glucose metabolic process ; GO:0010906 | inferred from mutant phenotype cellular response to hormone stimulus ; GO:0032870 | inferred from biological aspect of ancestor with PANTHER:PTN001552066 protein phosphorylation ; GO:0006468 | non-traceable author statement lipid homeostasis ; GO:0055088 | inferred from mutant phenotype intracellular signal transduction ; GO:0035556 | inferred from biological aspect of ancestor with PANTHER:PTN000678822 protein phosphorylation ; GO:0006468 | inferred from sequence or structural similarity with HGNC:21680 response to starvation ; GO:0042594 | inferred from mutant phenotype nucleus ; GO:0005634 | inferred from biological aspect of ancestor with PANTHER:PTN000678822 cytoplasm ; GO:0005737 | inferred from biological aspect of ancestor with PANTHER:PTN000678822 "CG15072, SIK, SIK3, Sik3, CG42856, EMK/KIAA0999, CG18604" "IPR028375:KA1 domain/Ssp2, C-terminal, IPR000719:Protein kinase domain, IPR008271:Serine/threonine-protein kinase, active site, IPR011009:Protein kinase-like domain, IPR017441:Protein kinase, ATP binding site, IPR001772:Kinase associated domain 1 (KA1)" CG42856 27-Aug-18 DroID_v2018_08 "Drer\sik2b, Drer\mark4a, Drer\mark3a, Drer\zgc:66101, Drer\mark3b, Drer\prkaa1, Drer\mark1, Drer\mark2a, Drer\mark2b, Drer\si:dkey-31m14.7, Drer\sik1, Drer\sik2a" "Scer\KIN2, Scer\SNF1, Scer\KIN1, Scer\PRR1" "Cele\par-1, Cele\kin-29" "Xtro\sik3, Xtro\prkaa1, Xtro\mark4, Xtro\mark2, Xtro\mark3, Xtro\sik2, Xtro\prkaa2" "Mmus\Gm6729, Mmus\Prkaa1, Mmus\Smok3b, Mmus\Gm6882, Mmus\Gm7168, Mmus\Smok2a, Mmus\1810024B03Rik, Mmus\Gm14147, Mmus\Sik1, Mmus\Mark4, Mmus\Gm4922, Mmus\Sik2, Mmus\Gm6902, Mmus\Prkaa2, Mmus\4921509C19Rik, Mmus\Gm6176, Mmus\Gm10668, Mmus\Mark3, Mmus\Mark2, Mmus\Gm14151, Mmus\Smok2b, Mmus\Gm5174, Mmus\Mark1, Mmus\Smok3a, Mmus\Sik3" "Hsap\SIK2, Hsap\SIK1, Hsap\MARK1, Hsap\SIK3, Hsap\MARK4, Hsap\PRKAA1, Hsap\MARK3, Hsap\PRKAA2, Hsap\MARK2" FBgn0021774 ms(2)985 ms(2)985 http://flybase.org/reports/FBgn0021774 - gene - - - "ms-985, ms(2)985" - - 27-Aug-18 DroID_v2018_08 - - - - - - "male sterile,recessive,viable" FBgn0083285 E(smoDN)2135 Enhancer of smoDN 2135 http://flybase.org/reports/FBgn0083285 gene - - - E(smoDN)2135 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0250897 zaa43d06 - http://flybase.org/reports/FBgn0250897 gene - - - "zaa43d06, zaa43d06x1" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0015563 vivi-repeat vivi-repeat http://flybase.org/reports/FBgn0015563 FBgn0025236 repeat_region - - - "Vivi, HP1-VS, VS, anon-EST:fe2A2, vivi-repeat" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0034210 CG6568 - http://flybase.org/reports/FBgn0034210 protein_coding_gene - - - CG6568 - CG6568 27-Aug-18 DroID_v2018_08 "Drer\si:dkey-56d12.4, Drer\zgc:113019, Drer\si:dkey-60a16.1" - - - - - viable FBgn0267180 asRNA:CR45620 - http://flybase.org/reports/FBgn0267180 non_protein_coding_gene - - - CR45620 - CR45620 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0020829 l(2)SA "South Amherst, Mass" http://flybase.org/reports/FBgn0020829 - gene - - - l(2)SA - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0065596 l(2)SH0889 lethal (2) SH0889 http://flybase.org/reports/FBgn0065596 gene - - - "l(2)SH0889, l(2)SH2 0889" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0004763 l(3)89Cd lethal (3) 89Cd http://flybase.org/reports/FBgn0004763 - gene - - - l(3)89Cd - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0043491 flea\polyprotein flea element polyprotein http://flybase.org/reports/FBgn0043491 transposable_element_gene "zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR001878 nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR001878, InterPro:IPR012337 aspartic-type endopeptidase activity ; GO:0004190 | inferred from electronic annotation with InterPro:IPR001969, InterPro:IPR001995" "proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR001969, InterPro:IPR001995 DNA integration ; GO:0015074 | inferred from electronic annotation with InterPro:IPR001584" - "blastopia\polyprotein, flea\polyprotein" "IPR034145:RTVL-H retropepsin domain, IPR026523:Paraneoplastic antigen Ma, IPR021109:Aspartic peptidase domain, IPR000477:Reverse transcriptase domain, IPR001584:Integrase, catalytic core, IPR001969:Aspartic peptidase, active site, IPR001995:Peptidase A2A, retrovirus, catalytic, IPR018061:Retropepsins, IPR012337:Ribonuclease H-like domain, IPR001878:Zinc finger, CCHC-type" - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0031678 CG31918 - http://flybase.org/reports/FBgn0031678 protein_coding_gene metalloendopeptidase activity ; GO:0004222 | inferred from electronic annotation with InterPro:IPR000718 "proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR000718, InterPro:IPR008753" - "CG18592, anon-WO0118547.477, CG31918" "IPR000718:Peptidase M13, IPR008753:Peptidase M13, N-terminal domain" CG31918 27-Aug-18 DroID_v2018_08 "Drer\ece2b, Drer\mmel1, Drer\phex, Drer\ece1" - "Cele\nep-26, Cele\nep-18, Cele\nep-7, Cele\nep-5, Cele\nep-19, Cele\nep-16, Cele\nep-10, Cele\nep-13, Cele\nep-24, Cele\nep-9, Cele\nep-21, Cele\nep-3, Cele\nep-20, Cele\nep-17, Cele\nep-23, Cele\nep-12, Cele\nep-8, Cele\nep-6" "Xtro\ece2, Xtro\ece1, Xtro\ecel1, Xtro\mmel1" "Mmus\Mmel1, Mmus\Ece2, Mmus\Ece1, Mmus\Ecel1, Mmus\Mme, Mmus\Phex, Mmus\Kel" "Hsap\MME, Hsap\KEL, Hsap\PHEX, Hsap\ECE2, Hsap\MMEL1, Hsap\ECEL1, Hsap\ECE1" viable dorsal appendage FBgn0045800 Uhg1 U snoRNA host gene 1 http://flybase.org/reports/FBgn0045800 non_protein_coding_gene - - - "Dros-UHG1, dUHG1, CG14486, CR32886, BEST:GM03135, Uhg1, dUhg1, FBgn0040741" - CR32886 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0264723 lncRNA:CR43991 - http://flybase.org/reports/FBgn0264723 non_protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CR43991, CG43991" - CR43991 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0005071 fs(2)OW212 female sterile (2) OW212 http://flybase.org/reports/FBgn0005071 - gene - - - fs(2)OW212 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0013259 E(var)45 E(var)45 http://flybase.org/reports/FBgn0013259 - gene - - - E(var)45 - - 27-Aug-18 DroID_v2018_08 - - - - - - "enhancer of variegation,dominant" FBgn0036325 CG10752 - http://flybase.org/reports/FBgn0036325 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "anon-WO0140519.236, CG10752" "IPR011705:BTB/Kelch-associated, IPR011333:SKP1/BTB/POZ domain" CG10752 27-Aug-18 DroID_v2018_08 Drer\klhl41a - - - - - viable FBgn0013550 l(3)100Ab lethal (3) 100Ab http://flybase.org/reports/FBgn0013550 - gene - - - l(3)100Ab - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0034458 Ir56d Ionotropic receptor 56d http://flybase.org/reports/FBgn0034458 protein_coding_gene ligand-gated ion channel activity ; GO:0015276 | inferred from sequence model detection of chemical stimulus ; GO:0009593 | inferred from sequence or structural similarity with Ir92a integral component of membrane ; GO:0016021 | inferred from sequence model "Ir56d, DmelIR56d, CG15904, IR56d" - CG15904 27-Aug-18 DroID_v2018_08 - - Cele\W02A2.5 - - "Hsap\GRIK3, Hsap\GRIK2" viable FBgn0261630 CG42713 - http://flybase.org/reports/FBgn0261630 protein_coding_gene serine-type endopeptidase inhibitor activity ; GO:0004867 | inferred from electronic annotation with InterPro:IPR002223 - - "CG42713, DMG4-MB6.chr2L.16.012" IPR002223:Pancreatic trypsin inhibitor Kunitz domain CG42713 27-Aug-18 DroID_v2018_08 "Drer\pi15a, Drer\r3hdml, Drer\pi15b, Drer\glipr2, Drer\crispld2, Drer\crispld1b, Drer\wu:fb59d01, Drer\LOC100536500, Drer\glipr1b, Drer\glipr2l, Drer\crispld1a" "Scer\PRY2, Scer\PRY1, Scer\PRY3" - "Xtro\crispld2, Xtro\r3hdml, Xtro\crisp2, Xtro\glipr2, Xtro\crisp3, Xtro\crisp1, Xtro\MGC108118" "Mmus\Crisp3, Mmus\Glipr2, Mmus\Glipr1, Mmus\Crispld2, Mmus\Glipr1l2, Mmus\Crisp4, Mmus\Pi15, Mmus\Crisp1, Mmus\Clec18a, Mmus\Glipr1l1, Mmus\Crisp2, Mmus\R3hdml, Mmus\Pi16, Mmus\Crispld1" "Hsap\CLEC18A, Hsap\CLEC18B, Hsap\PI16, Hsap\R3HDML, Hsap\CLEC18C, Hsap\CRISP2, Hsap\GLIPR2, Hsap\GLIPR1L2, Hsap\CRISPLD2, Hsap\GLIPR1, Hsap\CRISP1, Hsap\GLIPR1L1, Hsap\PI15, Hsap\CRISPLD1" FBgn0003119 po pale ocelli http://flybase.org/reports/FBgn0003119 - gene - ommochrome biosynthetic process ; GO:0006727 | inferred from mutant phenotype - "do, po" - - 27-Aug-18 DroID_v2018_08 - - - - - - ocellus pigment granule FBgn0038535 alt aluminum tubes http://flybase.org/reports/FBgn0038535 protein_coding_gene receptor activity ; GO:0004872 | inferred from biological aspect of ancestor with PANTHER:PTN001450043 "cuticle development ; GO:0042335 | inferred from genetic interaction with UniProtKB:Q0KHR3,UniProtKB:Q9VX75,UniProtKB:X2JCB3,UniProtKB:X2JFU8 translation ; GO:0006412 | inferred from biological aspect of ancestor with PANTHER:PTN001450043" lipid particle ; GO:0005811 | inferred from direct assay ribosome ; GO:0005840 | inferred from biological aspect of ancestor with PANTHER:PTN001450043 endomembrane system ; GO:0012505 | inferred from direct assay integral component of endoplasmic reticulum membrane ; GO:0030176 | inferred from biological aspect of ancestor with PANTHER:PTN001450043 "CG18212, alt, Q9VEH0_DROME" - CG18212 27-Aug-18 DroID_v2018_08 "Drer\rrbp1b, Drer\rrbp1a" - - Xtro\rrbp1 "Mmus\Ktn1, Mmus\Rrbp1" Hsap\RRBP1 "viable,fertile" FBgn0261850 Xpd Xeroderma pigmentosum D http://flybase.org/reports/FBgn0261850 protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR001945, InterPro:IPR002464, InterPro:IPR006555, InterPro:IPR010614, InterPro:IPR014013 DNA binding ; GO:0003677 | inferred from electronic annotation with InterPro:IPR001945, InterPro:IPR010614 transcription factor activity, core RNA polymerase binding ; GO:0000990 | contributes_to inferred by curator from GO:0005675 helicase activity ; GO:0004386 | inferred from sequence or structural similarity ATP-dependent 5'-3' DNA helicase activity ; GO:0043141 | inferred from sequence or structural similarity with SGD:S000000973" transcriptional open complex formation at RNA polymerase II promoter ; GO:0001113 | inferred from sequence or structural similarity with HGNC:3434 response to UV ; GO:0009411 | inferred from direct assay regulation of syncytial blastoderm mitotic cell cycle ; GO:0007348 | inferred from mutant phenotype promoter clearance from RNA polymerase II promoter ; GO:0001111 | inferred from sequence or structural similarity with HGNC:3434 nucleotide-excision repair ; GO:0006289 | inferred from sequence or structural similarity with HGNC:3434 inferred from sequence or structural similarity with SGD:S000000973 regulation of chromosome segregation ; GO:0051983 | inferred from mutant phenotype transcription initiation from RNA polymerase II promoter ; GO:0006367 | inferred from sequence or structural similarity with HGNC:3434 inferred from sequence or structural similarity with SGD:S000000973 negative regulation of G2/M transition of mitotic cell cycle ; GO:0010972 | inferred from direct assay response to UV ; GO:0009411 | inferred from mutant phenotype regulation of mitotic nuclear division ; GO:0007088 | inferred from mutant phenotype cellular response to DNA damage stimulus ; GO:0006974 | inferred from direct assay "polytene chromosome interband ; GO:0005705 | inferred from direct assay core TFIIH complex ; GO:0000439 | inferred from sequence or structural similarity with HGNC:3434 cytoplasm ; GO:0005737 | inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay holo TFIIH complex ; GO:0005675 | inferred from physical interaction with hay, CycH, Mat1, mrn, Cdk7 holo TFIIH complex ; GO:0005675 | inferred from sequence or structural similarity with SGD:S000000973 polytene chromosome puff ; GO:0005703 | inferred from direct assay polytene chromosome ; GO:0005700 | inferred from direct assay core TFIIH complex ; GO:0000439 | inferred from direct assay holo TFIIH complex ; GO:0005675 | inferred from sequence or structural similarity with HGNC:3434 inferred from sequence or structural similarity with SGD:S000000973" "Xpd, l(2)SH2137, xpd, XPD, XPD/ERCC2, CG9433, DmXPD, DhXPD, DhR3, ERCC2, l(2)SH2 2137" "IPR027417:P-loop containing nucleoside triphosphate hydrolase, IPR001945:RAD3/XPD family, IPR002464:DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site, IPR006554:Helicase-like, DEXD box c2 type, IPR006555:ATP-dependent helicase, C-terminal, IPR010643:Helical and beta-bridge domain, IPR013020:DNA helicase (DNA repair), Rad3 type, IPR014013:Helicase superfamily 1/2, ATP-binding domain, DinG/Rad3-type, IPR010614:DEAD2" CG9433 27-Aug-18 DroID_v2018_08 Drer\ercc2 Scer\RAD3 "Cele\Y50D7A.11, Cele\xpd-1" Xtro\ercc2 Mmus\Ercc2 Hsap\ERCC2 " embryonic stage | syncytial blastoderm , larval stage | third instar , embryonic stage | stage 5 , embryonic stage | stage >5 " "

ubiquitous , larval salivary gland

,

, embryonic/larval fat body

" FBgn0003188 qui quit http://flybase.org/reports/FBgn0003188 - gene molecular_function ; GO:0003674 | no biological data available ovarian follicle cell migration ; GO:0007297 | inferred from mutant phenotype oogenesis ; GO:0048477 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available qui - - 27-Aug-18 DroID_v2018_08 - - - - - - female sterile "nurse follicle cell,ovary" FBgn0017420 su(RpII215)S3 su(RpII215)S3 http://flybase.org/reports/FBgn0017420 - gene - - - "S3, anon-S3/S13, su(RpII215)S3" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0038248 CG7886 - http://flybase.org/reports/FBgn0038248 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available centrosome ; GO:0005813 | inferred from biological aspect of ancestor with PANTHER:PTN001189119 centrosome ; GO:0005813 | inferred from sequence or structural similarity with HGNC:25740 "anon-WO0140519.200, CG7886" "IPR032675:Leucine-rich repeat domain, L domain-like, IPR026212:Centrosomal protein of 78kDa" CG7886 27-Aug-18 DroID_v2018_08 "Drer\nod1, Drer\si:ch211-81a5.5, Drer\nlrx1, Drer\tonsl, Drer\si:dkey-23k10.3, Drer\lrrc34, Drer\nlrc3l, Drer\si:ch211-122c9.5, Drer\nod2, Drer\lrrc45, Drer\LOC101884653, Drer\cep78, Drer\nlrc3, Drer\ciita" - - "Xtro\nlrx1, Xtro\LOC100485518, Xtro\cep78, Xtro\lrrc31, Xtro\lrrc34, Xtro\tonsl, Xtro\lrrc45, Xtro\nod1" "Mmus\Cep78, Mmus\Lrrc74b, Mmus\Nlrp9c, Mmus\Nlrp4f, Mmus\Tonsl, Mmus\Lrrc71, Mmus\Lrrc74a, Mmus\Nod2, Mmus\Nlrc3, Mmus\Lrrc45, Mmus\Nlrp4c, Mmus\Nlrx1, Mmus\Ciita, Mmus\Nod1, Mmus\Nlrp4a, Mmus\Nlrp9a, Mmus\Lrrc34, Mmus\Nlrp14, Mmus\Nlrp4e, Mmus\Nlrp9b, Mmus\Lrrc31, Mmus\Rnh1" "Hsap\NOD2, Hsap\LRRC71, Hsap\LRRC74A, Hsap\CEP78, Hsap\NOD1, Hsap\TONSL, Hsap\LRRC45, Hsap\NLRP4, Hsap\NLRC5, Hsap\LRRC31, Hsap\CIITA, Hsap\NLRX1, Hsap\LRRC34, Hsap\NLRP14, Hsap\RNH1, Hsap\NLRP9" viable FBgn0013570 l(3)78Da lethal (3) 78Da http://flybase.org/reports/FBgn0013570 - gene - - - l(3)78Da - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0084254 E-3c4 Enhancer on chromosome 3-complementation group c4 http://flybase.org/reports/FBgn0084254 gene - - - "E-3c, E-3c4" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0259998 CG17571 - http://flybase.org/reports/FBgn0259998 protein_coding_gene serine-type endopeptidase activity ; GO:0004252 | inferred from biological aspect of ancestor with PANTHER:PTN001208729 serine-type endopeptidase activity ; GO:0004252 | inferred from sequence model "proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114 proteolysis ; GO:0006508 | inferred from sequence model" cytoplasm ; GO:0005737 | inferred from biological aspect of ancestor with PANTHER:PTN001208729 "CG17571, anon-38C.22, SP83, 38C.22" "IPR018114:Serine proteases, trypsin family, histidine active site, IPR001254:Serine proteases, trypsin domain, IPR001314:Peptidase S1A, chymotrypsin family, IPR009003:Peptidase S1, PA clan, IPR033116:Serine proteases, trypsin family, serine active site" CG17571 27-Aug-18 DroID_v2018_08 "Drer\zgc:123295, Drer\LOC562139, Drer\tmprss4b, Drer\zgc:163079, Drer\zgc:55888, Drer\prss60.3, Drer\ctrl, Drer\si:dkeyp-93a5.2, Drer\prss60.1, Drer\zgc:153968, Drer\prss60.2, Drer\zgc:92590, Drer\zgc:112160, Drer\try, Drer\zgc:112038" - "Cele\rab-11.1, Cele\svh-1, Cele\try-1" - "Mmus\Prss3, Mmus\Gm10334, Mmus\Try10, Mmus\Prss42, Mmus\2210010C04Rik, Mmus\Try4, Mmus\Prss2, Mmus\Prss1, Mmus\Ctrl, Mmus\Gm5771, Mmus\Prss34" "Hsap\PRSS1, Hsap\PRSS42, Hsap\CTRL, Hsap\PRSS3" DRSC01768 K 0.016076789 -0.063012137 -0.420297006 -0.048181006 -0.242862419 1.550058018 FBgn0033000 CG14464 - http://flybase.org/reports/FBgn0033000 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG40285, BcDNA:LD29015, CG14464" "IPR029264:ARF7 effector protein, C-terminal, IPR026515:ARL14 effector protein" CG14464 27-Aug-18 DroID_v2018_08 Drer\arl14ep - Cele\B0336.5 "Xtro\arl14epl, Xtro\arl14ep" "Mmus\Thap7, Mmus\Arl14ep, Mmus\Arl14epl" "Hsap\THAP7, Hsap\THAP8, Hsap\ARL14EP, Hsap\ARL14EPL" FBgn0022365 Pt-7A Adult protein-7A http://flybase.org/reports/FBgn0022365 - gene - - - Pt-7A - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0039284 CG13652 - http://flybase.org/reports/FBgn0039284 protein_coding_gene - - - CG13652 - - 27-Aug-18 DroID_v2018_08 - - - - - - "viable,visible" "tormogen cell,mesothoracic tergum" FBgn0060654 l(3)S083005b lethal (3) S083005b http://flybase.org/reports/FBgn0060654 gene - - - "0830/05, l(3)S083005b" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0260059 2L1749 - http://flybase.org/reports/FBgn0260059 gene - - - 2L1749 - - 27-Aug-18 DroID_v2018_08 - - - - - - "decreased cell size,somatic clone,lethal,recessive" "embryonic/larval tracheal system,somatic clone" FBgn0043573 S(faf)244 S(faf)244 http://flybase.org/reports/FBgn0043573 gene - - - S(faf)244 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0033283 CG11635 - http://flybase.org/reports/FBgn0033283 protein_coding_gene - - - CG11635 "IPR006611:Protein of unknown function DUF1431, cysteine-rich, Drosophila" CG11635 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0266048 lncRNA:CR44813 - http://flybase.org/reports/FBgn0266048 non_protein_coding_gene - - - "CR44813, lincRNA.390" - CR44813 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0030976 CG7378 - http://flybase.org/reports/FBgn0030976 protein_coding_gene "protein tyrosine phosphatase activity ; GO:0004725 | inferred from electronic annotation with InterPro:IPR016130 protein tyrosine/serine/threonine phosphatase activity ; GO:0008138 | inferred from electronic annotation with InterPro:IPR000340, InterPro:IPR020405, InterPro:IPR020417, InterPro:IPR020422 protein tyrosine/serine/threonine phosphatase activity ; GO:0008138 | non-traceable author statement" "protein dephosphorylation ; GO:0006470 | inferred from electronic annotation with InterPro:IPR000340, InterPro:IPR020405, InterPro:IPR020417, InterPro:IPR020422 protein dephosphorylation ; GO:0006470 | non-traceable author statement" cellular_component ; GO:0005575 | no biological data available "BcDNA:RH25447, CG7378, MKP-like" "IPR000340:Dual specificity phosphatase, catalytic domain, IPR000387:Tyrosine specific protein phosphatases domain, IPR016130:Protein-tyrosine phosphatase, active site, IPR020405:Atypical dual specificity phosphatase, subfamily A, IPR020417:Atypical dual specificity phosphatase, IPR020422:Dual specificity protein phosphatase domain, IPR024950:Dual specificity phosphatase, IPR029021:Protein-tyrosine phosphatase-like" CG7378 27-Aug-18 DroID_v2018_08 "Drer\dusp16, Drer\dupd1, Drer\dusp10, Drer\si:ch211-203d1.3, Drer\dusp7, Drer\si:ch211-195b15.8, Drer\dusp3a, Drer\dusp19b, Drer\dusp13a, Drer\si:ch211-223p8.8, Drer\dusp12, Drer\dusp14, Drer\dusp19a, Drer\si:dkey-175m17.7, Drer\dusp22a, Drer\dusp1, Drer\zgc:153981, Drer\dusp2, Drer\dusp27, Drer\styx, Drer\zgc:153044, Drer\dusp6, Drer\dusp8b, Drer\dusp8a, Drer\si:ch1073-184j22.2, Drer\styxl1, Drer\ssh2a, Drer\dusp26, Drer\ssh1a, Drer\dusp5, Drer\dusp22b, Drer\dusp3b, Drer\si:ch211-121a2.2, Drer\ssh1b, Drer\dusp4, Drer\ssh2b" "Scer\MSG5, Scer\SDP1, Scer\YVH1, Scer\PPS1" "Cele\F13D11.3, Cele\lip-1, Cele\Y54F10BM.13, Cele\W09H1.1, Cele\F26A3.4, Cele\C04F12.8, Cele\C16A3.2" "Xtro\dusp19, Xtro\dusp4, Xtro\dusp22, Xtro\dusp22a, Xtro\dusp9, Xtro\epm2a, Xtro\dusp5, Xtro\styx, Xtro\ssh1, Xtro\dupd1, Xtro\ssh2, Xtro\dusp1, Xtro\dusp6, Xtro\dusp12, Xtro\dusp18, Xtro\styxl1, Xtro\dusp26, Xtro\dusp10" "Mmus\Styx, Mmus\Ssh2, Mmus\Dusp4, Mmus\Dusp6, Mmus\Dusp8, Mmus\Dusp19, Mmus\Dusp16, Mmus\Dusp13, Mmus\Dusp3, Mmus\Dusp18, Mmus\Epm2a, Mmus\Dusp7, Mmus\Dupd1, Mmus\Styxl1, Mmus\Dusp2, Mmus\Dusp14, Mmus\Ssh1, Mmus\Ssh3, Mmus\Dusp27, Mmus\Dusp5, Mmus\Dusp15, Mmus\Dusp9, Mmus\Dusp1, Mmus\Dusp10, Mmus\Dusp12, Mmus\Dusp22, Mmus\Dusp26, Mmus\Dusp21" "Hsap\DUSP1, Hsap\DUSP6, Hsap\DUSP27, Hsap\SSH2, Hsap\DUSP9, Hsap\DUSP21, Hsap\EPM2A, Hsap\SSH1, Hsap\DUSP15, Hsap\SSH3, Hsap\DUPD1, Hsap\DUSP12, Hsap\DUSP22, Hsap\DUSP26, Hsap\DUSP4, Hsap\DUSP18, Hsap\STYX, Hsap\DUSP16, Hsap\DUSP19, Hsap\DUSP8, Hsap\DUSP3, Hsap\DUSP13, Hsap\STYXL1, Hsap\DUSP7, Hsap\DUSP2, Hsap\DUSP5, Hsap\DUSP10" viable FBgn0002050 l(2)37Fc lethal (2) 37Fc http://flybase.org/reports/FBgn0002050 - gene - - - "l(2)E42, l(2)37Fc" - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0021834 l(2)k15817 lethal (2) k15817 http://flybase.org/reports/FBgn0021834 - gene - - - l(2)k15817 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0065526 l(2)SH1118 lethal (2) SH1118 http://flybase.org/reports/FBgn0065526 gene - - - "l(2)SH1118, l(2)SH2 1118" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0259585 B2030 - http://flybase.org/reports/FBgn0259585 gene - - - B2030 - - 27-Aug-18 DroID_v2018_08 - - - - - - visible metathoracic leg FBgn0020255 Ran Ran http://flybase.org/reports/FBgn0020255 "FBgn0026685, FBgn0030273" protein_coding_gene GTPase activity ; GO:0003924 | inferred from biological aspect of ancestor with PANTHER:PTN000632582 protein binding ; GO:0005515 | inferred from physical interaction with cno GTP binding ; GO:0005525 | inferred from direct assay GTPase activity ; GO:0003924 | inferred from sequence or structural similarity with SGD:S000005711 protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q9W1A4 GTPase activity ; GO:0003924 | inferred from sequence or structural similarity signal transduction ; GO:0007165 | inferred from electronic annotation with InterPro:IPR002041 actin filament organization ; GO:0007015 | inferred from mutant phenotype establishment of mitotic spindle orientation ; GO:0000132 | inferred from mutant phenotype inferred from genetic interaction with dlg1 inferred from genetic interaction with cno regulation of mitotic cell cycle ; GO:0007346 | inferred from direct assay protein import into nucleus ; GO:0006606 | inferred from biological aspect of ancestor with PANTHER:PTN000632582 meiotic spindle organization ; GO:0000212 | inferred from mutant phenotype cell adhesion ; GO:0007155 | inferred from mutant phenotype cellular response to starvation ; GO:0009267 | inferred from expression pattern cell cycle ; GO:0007049 | inferred from direct assay regulation of protein localization ; GO:0032880 | inferred from mutant phenotype protein export from nucleus ; GO:0006611 | inferred from sequence or structural similarity with HGNC:9846 regulation of cell shape ; GO:0008360 | inferred from mutant phenotype neuron projection morphogenesis ; GO:0048812 | inferred from mutant phenotype ribosomal subunit export from nucleus ; GO:0000054 | inferred from biological aspect of ancestor with PANTHER:PTN000632582 intracellular protein transport ; GO:0006886 | traceable author statement microtubule associated complex ; GO:0005875 | inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay mitotic spindle ; GO:0072686 | inferred from direct assay cell cortex ; GO:0005938 | inferred from direct assay lipid particle ; GO:0005811 | inferred from direct assay nuclear microtubule ; GO:0005880 | inferred from direct assay "Ran, AAF30287, CG1404, ran10A, dran, l(1)G0075, ran, Q9VZ23, RanGTP" "IPR002041:Ran GTPase, IPR005225:Small GTP-binding protein domain, IPR001806:Small GTPase superfamily, IPR027417:P-loop containing nucleoside triphosphate hydrolase" CG1404 27-Aug-18 DroID_v2018_08 Drer\ran "Scer\GSP1, Scer\GSP2" Cele\ran-1 Xtro\ran "Mmus\1700009N14Rik, Mmus\Rasl2-9, Mmus\Ran" Hsap\RAN embryonic stage organism

"viable,wild-type,female sterile,male sterile,lethal,fertile,partially lethal - majority die,recessive,lethal - all die before end of P-stage,some die during pharate adult stage,visible,lethal - all die before end of larval stage,some die during larval stage" "karyosome,meiotic spindlenos.UTR.THsimVP16,ommatidium,photoreceptor cell,photoreceptor cell R7,cone cell,pigment cell" DRSC20364 I -1.583757533 0.054210938 -1.360761974 -0.590233519 0.303333163 0.629600729 FBgn0050021 metro menage a trois http://flybase.org/reports/FBgn0050021 protein_coding_gene - neuron projection morphogenesis ; GO:0048812 | inferred from mutant phenotype regulation of synaptic growth at neuromuscular junction ; GO:0008582 | inferred from mutant phenotype subsynaptic reticulum ; GO:0071212 | inferred from direct assay "CG18338, CG13219, CG30021, Metro, metro, skf, FBgn0050021, skiff" "IPR027417:P-loop containing nucleoside triphosphate hydrolase, IPR001452:SH3 domain, IPR001478:PDZ domain, IPR004172:L27 domain, IPR008144:Guanylate kinase-like domain, IPR008145:Guanylate kinase/L-type calcium channel beta subunit, IPR011511:Variant SH3 domain, IPR020590:Guanylate kinase, conserved site" CG30021 27-Aug-18 DroID_v2018_08 "Drer\LOC556594, Drer\si:ch73-272h16.4, Drer\mpp3a, Drer\caska, Drer\mpp3b, Drer\mpp5b, Drer\mpp2b, Drer\mpp5a, Drer\mpp6a, Drer\mpp1, Drer\mpp4a, Drer\mpp7a, Drer\mpp2a, Drer\mpp7b, Drer\mpp6b" Scer\GUK1 "Cele\magu-1, Cele\lin-2, Cele\magu-2" "Xtro\mpp2, Xtro\mpp6, Xtro\cask, Xtro\mpp1, Xtro\mpp7, Xtro\mpp5" "Mmus\Mpp5, Mmus\Mpp3, Mmus\Cask, Mmus\Mpp7, Mmus\Mpp6, Mmus\Mpp2, Mmus\Mpp1, Mmus\Mpp4" "Hsap\MPP4, Hsap\MPP3, Hsap\CASK, Hsap\MPP7, Hsap\MPP1, Hsap\MPP6, Hsap\MPP2, Hsap\MPP5" "viable,fertile,neuroanatomy defective" neuromuscular junction FBgn0086666 snoRNA:Psi28S-2179 snoRNA:Psi28S-2179 http://flybase.org/reports/FBgn0086666 snoRNA_gene - - - "snoRNA:734, psi28S-2179, Dm-734, snoR734, CR33918, Psi28S-2719(SnoR734), SnoR734, Psi28S-2719, snoRNA:Psi28S-2179" - CR33918 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0015918 cant cat of nine tails http://flybase.org/reports/FBgn0015918 - gene - - - cant - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0086392 BG02053 - http://flybase.org/reports/FBgn0086392 gene - olfactory behavior ; GO:0042048 | inferred from mutant phenotype - BG02053 - - 27-Aug-18 DroID_v2018_08 - - - - - - "viable,smell perception defective" FBgn0000386 ctt contorted http://flybase.org/reports/FBgn0000386 - gene - - - ctt - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,recessive,female sterile,male fertile" "wing,eye,macrochaeta,anterior orbital bristle,middle orbital bristle,posterior orbital bristle,genitalia,male,orbital bristle,male genitalia" FBgn0014378 raz razorback http://flybase.org/reports/FBgn0014378 - gene - - - raz - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0015554 ttp tip-tap http://flybase.org/reports/FBgn0015554 - gene - - - ttp - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0001350 l(1)1Ee lethal (1) 1Ee http://flybase.org/reports/FBgn0001350 - gene - - - l(1)1Ee - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0265946 lncRNA:CR44733 - http://flybase.org/reports/FBgn0265946 non_protein_coding_gene - - - CR44733 - CR44733 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0069224 gl(2R)18-14 gl(2R)18-14 http://flybase.org/reports/FBgn0069224 gene molecular_function ; GO:0003674 | no biological data available segment specification ; GO:0007379 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available gl(2R)18-14 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,germline clone,maternal effect,recessive,lethal - all die before end of embryonic stage,some die during embryonic stage" "embryonic segment,germline clone,maternal effect,embryonic head,denticle belt" FBgn0033782 sug sugarbabe http://flybase.org/reports/FBgn0033782 protein_coding_gene nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR013087 "negative regulation of transcription, DNA-templated ; GO:0045892 | inferred from sequence or structural similarity with UniProtKB:Q8VDL9 positive regulation of transcription, DNA-templated ; GO:0045893 | inferred from sequence or structural similarity with UniProtKB:Q8VDL9 insulin-like growth factor receptor signaling pathway ; GO:0048009 | inferred from mutant phenotype response to starvation ; GO:0042594 | inferred from mutant phenotype negative regulation of transcription from RNA polymerase II promoter ; GO:0000122 | inferred from direct assay cellular response to nutrient ; GO:0031670 | inferred from direct assay" nuclear speck ; GO:0016607 | inferred from sequence or structural similarity with UniProtKB:Q8VDL9 "CG3850, sug" "IPR013087:Zinc finger C2H2-type, IPR013083:Zinc finger, RING/FYVE/PHD-type" CG3850 27-Aug-18 DroID_v2018_08 "Drer\glis2a, Drer\glis2b, Drer\glis3, Drer\aaas, Drer\LOC100333406" "Scer\YPR015C, Scer\CMR3" "Cele\ztf-14, Cele\ref-2" "Xtro\glis2, Xtro\aaas, Xtro\glis3" "Mmus\Prdm5, Mmus\Glis1, Mmus\Glis2, Mmus\Aaas" "Hsap\AAAS, Hsap\ZKSCAN5, Hsap\GLIS2, Hsap\GLIS3, Hsap\GLIS1" "developmental rate defective,heat sensitive,lethal,male,starvation stress response defective,viable" FBgn0265718 lncRNA:CR44525 - http://flybase.org/reports/FBgn0265718 non_protein_coding_gene - - - "incRNA.462, CR44525, lincRNA.462" - CR44525 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0039647 jus - http://flybase.org/reports/FBgn0039647 protein_coding_gene - olfactory behavior ; GO:0042048 | inferred from mutant phenotype - "CG14510, CG14509" - CG14509 27-Aug-18 DroID_v2018_08 - - - - - - "viable,smell perception defective,fertile" FBgn0259467 C166 - http://flybase.org/reports/FBgn0259467 gene - - - C166 - - 27-Aug-18 DroID_v2018_08 - - - - - - visible "wing hair,wing vein" FBgn0002494 l(3)SG54 lethal (3) SG54 http://flybase.org/reports/FBgn0002494 - gene - - - l(3)SG54 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of embryonic stage,recessive,heat sensitive,some die during embryonic stage" FBgn0002823 ms(2)38C male sterile (2) 38C http://flybase.org/reports/FBgn0002823 - gene - - - "ms, ms(2)38C" - - 27-Aug-18 DroID_v2018_08 - - - - - - "male sterile,recessive" FBgn0065637 l(2)SH0765 lethal (2) SH0765 http://flybase.org/reports/FBgn0065637 gene - - - "l(2)SH0765, l(2)SH2 0765" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0014340 mof males absent on the first http://flybase.org/reports/FBgn0014340 - protein_coding_gene "chromatin binding ; GO:0003682 | inferred from direct assay mRNA binding ; GO:0003729 | traceable author statement histone acetyltransferase activity (H4-K16 specific) ; GO:0046972 | traceable author statement histone acetyltransferase activity ; GO:0004402 | traceable author statement protein binding ; GO:0005515 | inferred from physical interaction with nsl1 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor ; GO:0004468 | traceable author statement histone acetyltransferase activity ; GO:0004402 | inferred from direct assay histone acetyltransferase activity (H4-K16 specific) ; GO:0046972 | inferred from mutant phenotype histone acetyltransferase activity ; GO:0004402 | inferred from sequence or structural similarity with SGD:S000000148 inferred from sequence or structural similarity with SGD:S000004734" "dosage compensation by hyperactivation of X chromosome ; GO:0009047 | non-traceable author statement histone H4-K16 acetylation ; GO:0043984 | inferred from mutant phenotype negative regulation of apoptotic process ; GO:0043066 | inferred from mutant phenotype DNA repair ; GO:0006281 | inferred from mutant phenotype DNA damage checkpoint ; GO:0000077 | inferred from mutant phenotype histone acetylation ; GO:0016573 | traceable author statement positive regulation of sequence-specific DNA binding transcription factor activity ; GO:0051091 | inferred from mutant phenotype response to ionizing radiation ; GO:0010212 | inferred from mutant phenotype peptidyl-lysine acetylation ; GO:0018394 | traceable author statement regulation of histone H4 acetylation involved in response to DNA damage stimulus ; GO:2000873 | inferred from mutant phenotype dosage compensation ; GO:0007549 | inferred from mutant phenotype inferred from genetic interaction with msl-2 cellular response to ionizing radiation ; GO:0071479 | inferred from mutant phenotype DNA damage response, signal transduction by p53 class mediator ; GO:0030330 | inferred from mutant phenotype" "MSL complex ; GO:0072487 | inferred from direct assay X chromosome located dosage compensation complex, transcription activating ; GO:0016456 | non-traceable author statement nucleus ; GO:0005634 | inferred from direct assay X chromosome ; GO:0000805 | traceable author statement X chromosome located dosage compensation complex, transcription activating ; GO:0016456 | traceable author statement polytene chromosome interband ; GO:0005705 | inferred from direct assay X chromosome located dosage compensation complex, transcription activating ; GO:0016456 | inferred from direct assay transcription factor complex ; GO:0005667 | inferred from direct assay NSL complex ; GO:0044545 | inferred from direct assay nuclear chromosome ; GO:0000228 | inferred from direct assay" "MOF, CG3025, dMOF, dmMOF, Mof, max, mof" "IPR002717:Histone acetyltransferase domain, MYST-type, IPR016181:Acyl-CoA N-acyltransferase, IPR016197:Chromo domain-like, IPR025995:RNA binding activity-knot of a chromodomain" CG3025 27-Aug-18 DroID_v2018_08 "Drer\kat5a, Drer\kat6b, Drer\kat8, Drer\kat7b, Drer\kat7a, Drer\kat5b, Drer\kat6a" "Scer\ESA1, Scer\SAS3, Scer\SAS2" "Cele\mys-4, Cele\mys-1, Cele\mys-2" "Xtro\kat5, Xtro\trim69.1, Xtro\xnf7, Xtro\kat7, Xtro\kat8" "Mmus\Kat5, Mmus\Kat8, Mmus\Kat6a, Mmus\Kat7, Mmus\Kat6b" "Hsap\KAT5, Hsap\KAT8, Hsap\KAT6B, Hsap\KAT6A, Hsap\KAT7" larval stage--adult stage "female fertile,non-suppressor of variegation,wild-type,lethal,male,recessive,viable,female,increased cell death,radiation sensitive,partially lethal - majority die,female sterile,short lived,male limited,large body,female limited,decreased cell growth,lethal - all die during larval stage" "heart primordium,eye disc,wing disc,embryonic/larval fat body" FBgn0065259 l(2)SH2089 lethal (2) SH2089 http://flybase.org/reports/FBgn0065259 gene - - - l(2)SH2089 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0262107 asRNA:CR42860 - http://flybase.org/reports/FBgn0262107 non_protein_coding_gene - - - CR42860 - CR42860 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0001598 l(1)CP8 lethal (1) CP8 http://flybase.org/reports/FBgn0001598 - gene - - - l(1)CP8 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0021843 l(2)k14816 lethal (2) k14816 http://flybase.org/reports/FBgn0021843 - gene - - - l(2)k14816 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0035799 CG14838 - http://flybase.org/reports/FBgn0035799 protein_coding_gene molecular_function ; GO:0003674 | no biological data available - - CG14838 "IPR017986:WD40-repeat-containing domain, IPR015943:WD40/YVTN repeat-like-containing domain" CG14838 27-Aug-18 DroID_v2018_08 Drer\wdr63 - Cele\pfs-2 "Xtro\wdr63, Xtro\LOC101732357" Mmus\Wdr63 Hsap\WDR63 "viable,fertile" FBgn0085398 ppk9 pickpocket 9 http://flybase.org/reports/FBgn0085398 protein_coding_gene sodium channel activity ; GO:0005272 | inferred from sequence or structural similarity with MGI:MGI:101782 sodium ion transport ; GO:0006814 | inferred from sequence or structural similarity with MGI:MGI:101782 integral component of membrane ; GO:0016021 | inferred from sequence or structural similarity with MGI:MGI:101782 "CG13489, CG13490, ppk9, CG34369" IPR001873:Epithelial sodium channel CG34369 27-Aug-18 DroID_v2018_08 "Drer\asic1b, Drer\asic4a, Drer\asic2, Drer\asic1a, Drer\asic1c, Drer\asic4b" - "Cele\acd-1, Cele\flr-1, Cele\acd-4, Cele\del-7, Cele\delm-1, Cele\acd-2, Cele\delm-2, Cele\acd-3, Cele\acd-5" "Xtro\scnn1a, Xtro\asic5, Xtro\asic4, Xtro\scnn1d, Xtro\scnn1b, Xtro\scnn1g, Xtro\asic1" "Mmus\Scnn1b, Mmus\Asic4, Mmus\Asic2, Mmus\Asic3, Mmus\Asic5, Mmus\Scnn1a, Mmus\Asic1, Mmus\Scnn1g" "Hsap\SCNN1G, Hsap\SCNN1A, Hsap\SCNN1B, Hsap\ASIC3, Hsap\SCNN1D, Hsap\ASIC5, Hsap\ASIC1, Hsap\ASIC4, Hsap\ASIC2" DRSC04135 I 1.539440532 -1.736385215 -0.663016632 -1.327574442 -0.028808552 -0.56408249 FBgn0085252 CG34223 - http://flybase.org/reports/FBgn0085252 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG34223 - CG34223 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0034514 CG13427 - http://flybase.org/reports/FBgn0034514 protein_coding_gene - gastrulation ; GO:0007369 | inferred from expression pattern vesicle ; GO:0031982 | inferred from direct assay CG13427 - CG13427 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0070024 BG00488 BG00488 http://flybase.org/reports/FBgn0070024 gene - - - BG00488 - - 27-Aug-18 DroID_v2018_08 - - - - - - stress response defective FBgn0050201 tRNA:Ser-TGA-1-1 transfer RNA:Serine-TGA 1-1 http://flybase.org/reports/FBgn0050201 tRNA_gene UCA codon-amino acid adaptor activity ; GO:0033407 | inferred from sequence model translation ; GO:0006412 | inferred by curator from GO:0033407 cytosol ; GO:0005829 | inferred by curator from GO:0033407 "CR30201, AE002575.trna9-SerTGA, tRNA:S:TGA:AE002575-b, tRNA[[Ser]], chr2R:18579596..18579746, chr2R.trna53-SerTGA, tRNA-Ser-TGA-1-1, tRNA:Ser-TGA-1-1, tRNA:CR30201, UCA" - CR30201 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0023110 anon-10Ax anon-10Ax http://flybase.org/reports/FBgn0023110 - gene - - - "17, anon-10Ax" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0043849 412\ORF1 412 element ORF1 http://flybase.org/reports/FBgn0043849 transposable_element_gene - - - "412\ORF1, ORF1" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0031048 CG12237 - http://flybase.org/reports/FBgn0031048 protein_coding_gene pyrophosphatase activity ; GO:0016462 | inferred from sequence or structural similarity with HGNC:16815 phosphatase activity ; GO:0016791 | inferred from biological aspect of ancestor with PANTHER:PTN000467154 biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG12237, 16769716" "IPR006384:Pyridoxal phosphate phosphatase-related, IPR016965:Phosphatase PHOSPHO-type, IPR023214:HAD-like domain" CG12237 27-Aug-18 DroID_v2018_08 "Drer\phospho2, Drer\phospho1" - "Cele\irld-49, Cele\irld-51, Cele\irld-56, Cele\irld-67, Cele\irld-60, Cele\irld-64, Cele\irld-39, Cele\hpa-1" Xtro\phospho2 "Mmus\Phospho2, Mmus\Phospho1" "Hsap\PHOSPHO1, Hsap\PHOSPHO2" FBgn0029730 boil boilerman http://flybase.org/reports/FBgn0029730 protein_coding_gene molecular_function ; GO:0003674 | no biological data available detection of temperature stimulus involved in sensory perception of pain ; GO:0050965 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available "CG12681, boil" IPR031732:Protein of unknown function DUF4729 CG12681 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0028945 CG7631 - http://flybase.org/reports/FBgn0028945 protein_coding_gene metalloendopeptidase activity ; GO:0004222 | inferred from electronic annotation with InterPro:IPR001506 zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR006026 "proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR001506, InterPro:IPR006026 lateral inhibition ; GO:0046331 | inferred from mutant phenotype" - "BG:BACR44L22.6, CG7631" "IPR001506:Peptidase M12A, IPR006026:Peptidase, metallopeptidase, IPR024079:Metallopeptidase, catalytic domain, IPR034035:Astacin-like metallopeptidase domain" CG7631 27-Aug-18 DroID_v2018_08 "Drer\LOC100003133, Drer\LOC797085, Drer\c6ast3, Drer\npsnl, Drer\mep1a.1, Drer\bmp1a, Drer\npsn, Drer\bmp1b, Drer\mep1a.2, Drer\tnfaip6, Drer\he2, Drer\c6ast1, Drer\c6ast4, Drer\si:ch73-40a17.3, Drer\mep1b, Drer\he1b, Drer\he1a, Drer\tll1" - "Cele\nas-6, Cele\nas-4, Cele\nas-39, Cele\nas-13, Cele\Y19D10A.6, Cele\nas-8, Cele\nas-14, Cele\nas-15, Cele\nas-2, Cele\nas-7, Cele\nas-12, Cele\nas-1, Cele\ZC116.3" "Xtro\mep1b, Xtro\bmp1, Xtro\uvs.2, Xtro\accs, Xtro\LOC100492324, Xtro\tll1, Xtro\LOC100489456, Xtro\tll2, Xtro\tnfaip6, Xtro\cubn, Xtro\mep1a" "Mmus\Mep1a, Mmus\Cubn, Mmus\Tll2, Mmus\Adgrg6, Mmus\Tnfaip6, Mmus\Astl, Mmus\Mep1b, Mmus\Tll1, Mmus\Bmp1" "Hsap\ASTL, Hsap\ADGRG6, Hsap\TNFAIP6, Hsap\MEP1B, Hsap\BMP1, Hsap\MEP1A, Hsap\TLL1, Hsap\TLL2, Hsap\CUBN" "viable,visible" "chaeta,supernumerary" FBgn0261566 CG42680 - http://flybase.org/reports/FBgn0261566 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG42680 - CG42680 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0265723 lncRNA:CR44530 - http://flybase.org/reports/FBgn0265723 non_protein_coding_gene - - - "incRNA.420, CR44530, lincRNA.420" - CR44530 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0019878 anon-69Ae anon-69Ae http://flybase.org/reports/FBgn0019878 - gene - - - anon-69Ae - - 27-Aug-18 DroID_v2018_08 - - - - - - larval stage FBgn0034139 CG4927 - http://flybase.org/reports/FBgn0034139 protein_coding_gene "serine-type endopeptidase activity ; GO:0004252 | inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114 serine-type endopeptidase activity ; GO:0004252 | inferred from sequence model" "proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114 proteolysis ; GO:0006508 | inferred from sequence model" - "SP42, CG4927" "IPR001254:Serine proteases, trypsin domain, IPR001314:Peptidase S1A, chymotrypsin family, IPR009003:Peptidase S1, PA clan, IPR018114:Serine proteases, trypsin family, histidine active site, IPR033116:Serine proteases, trypsin family, serine active site" CG4927 27-Aug-18 DroID_v2018_08 - - Cele\svh-1 - "Mmus\Prss12, Mmus\F12, Mmus\Plat, Mmus\Hgfac, Mmus\Plau, Mmus\Habp2" Hsap\MASP1 "viable,fertile" DRSC06903 I 1.700280649 -0.04912185 -1.071771863 -0.039939986 0.846974055 -0.144782249 FBgn0038943 CG5391 - http://flybase.org/reports/FBgn0038943 protein_coding_gene - - - CG5391 - CG5391 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0000002 5SrRNA 5S ribosomal RNA http://flybase.org/reports/FBgn0000002 FBgn0010528 rRNA_gene - - cytosolic large ribosomal subunit ; GO:0022625 | non-traceable author statement "5S RNA, 5S rRNA, 5SrDNA, 5S-rDNA, 5SRNA, 5S rDNA, 5S, 2S rRNA, l(2)03068, PZ03068, RNA X, Dm5S, 5SrRNA, rRNA, 5S_DM" - - 27-Aug-18 DroID_v2018_08 - - - - - - "partially lethal - majority die,lethal,recessive" FBgn0261458 capt capulet http://flybase.org/reports/FBgn0261458 protein_coding_gene actin binding ; GO:0003779 | inferred from biological aspect of ancestor with PANTHER:PTN000068843 actin binding ; GO:0003779 | inferred from sequence or structural similarity adenylate cyclase binding ; GO:0008179 | inferred from sequence or structural similarity with PomBase:SPCC306.09c adenylate cyclase binding ; GO:0008179 | inferred from biological aspect of ancestor with PANTHER:PTN000068843 photoreceptor cell axon guidance ; GO:0072499 | inferred from mutant phenotype regulation of adenylate cyclase activity ; GO:0045761 | inferred from biological aspect of ancestor with PANTHER:PTN000068843 actin filament organization ; GO:0007015 | inferred from mutant phenotype chaeta morphogenesis ; GO:0008407 | inferred from mutant phenotype wing disc dorsal/ventral pattern formation ; GO:0048190 | inferred from mutant phenotype compound eye development ; GO:0048749 | inferred from mutant phenotype cell morphogenesis ; GO:0000902 | inferred from mutant phenotype actin polymerization or depolymerization ; GO:0008154 | inferred from mutant phenotype rhabdomere development ; GO:0042052 | inferred from mutant phenotype muscle cell cellular homeostasis ; GO:0046716 | inferred from genetic interaction with Dys oogenesis ; GO:0048477 | inferred from mutant phenotype signal transduction ; GO:0007165 | inferred from biological aspect of ancestor with PANTHER:PTN000068843 oocyte microtubule cytoskeleton polarization ; GO:0008103 | inferred from mutant phenotype regulation of cell shape ; GO:0008360 | inferred from mutant phenotype cytoplasm ; GO:0005737 | inferred from direct assay cortical actin cytoskeleton ; GO:0030864 | inferred from biological aspect of ancestor with PANTHER:PTN000068843 "capt, CG5061, CG33979, cyclase-associated protein, capping protein, CAP, Cap, acu, cap, Capt, Acap, l(2)06955, Dcap, CG5074, BcDNA:LD24380, punc, CP" "IPR001837:Adenylate cyclase-associated CAP, IPR003124:WH2 domain, IPR006599:CARP motif, IPR013912:Adenylate cyclase-associated CAP, C-terminal, IPR013992:Adenylate cyclase-associated CAP, N-terminal, IPR017901:C-CAP/cofactor C-like domain, IPR028417:CAP, conserved site, C-terminal" CG33979 27-Aug-18 DroID_v2018_08 "Drer\cap2, Drer\cap1" Scer\SRV2 "Cele\cas-1, Cele\cas-2, Cele\Y65B4A.4" "Xtro\cap2, Xtro\cap1" "Mmus\Cap1, Mmus\Cap2" "Hsap\CAP1, Hsap\CAP2" FBgn0050439 CG30439 - http://flybase.org/reports/FBgn0050439 protein_coding_gene - - - CG30439 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0053504 snRNA:U7 small nuclear RNA U7 http://flybase.org/reports/FBgn0053504 snRNA_gene mRNA binding ; GO:0003729 | inferred from direct assay histone mRNA metabolic process ; GO:0008334 | inferred from direct assay mRNA 3'-end processing by stem-loop binding and cleavage ; GO:0006398 | inferred from mutant phenotype oocyte development ; GO:0048599 | inferred from mutant phenotype nuclear body ; GO:0016604 | inferred from direct assay cytoplasmic U snRNP body ; GO:0071254 | inferred from direct assay histone locus body ; GO:0035363 | inferred from direct assay U7 snRNP ; GO:0005683 | inferred from direct assay "U7 snRNA, CR33504, snRNA:U7, U7, U7snRNA, 63E-F U7" - CR33504 27-Aug-18 DroID_v2018_08 - - - - - - "male sterile,recessive,female sterile,viable" FBgn0065252 l(2)SH2114 lethal (2) SH2114 http://flybase.org/reports/FBgn0065252 gene - - - "l(2)SH2114, l(2)SH2 2114" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0063915 McClintock\pol McClintock element pol http://flybase.org/reports/FBgn0063915 transposable_element_gene nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR012337 DNA integration ; GO:0015074 | inferred from electronic annotation with InterPro:IPR001584 - McClintock\pol "IPR000477:Reverse transcriptase domain, IPR001584:Integrase, catalytic core, IPR012337:Ribonuclease H-like domain" - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0004111 opa-e opa repeat http://flybase.org/reports/FBgn0004111 - repeat_region - - - "opa, CAX repeat, strep, CAX, M-repeat, M, opa-e" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0016678 Mab13G5 Monoclonal antibody 13G5 http://flybase.org/reports/FBgn0016678 - gene - - - Mab13G5 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0046121 E(To)4 E(To)4 http://flybase.org/reports/FBgn0046121 gene - - - E(To)4 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0036958 CG17233 - http://flybase.org/reports/FBgn0036958 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG6918, CG17233" "IPR025451:Domain of unknown function DUF4211, IPR011989:Armadillo-like helical, IPR015943:WD40/YVTN repeat-like-containing domain" CG17233 27-Aug-18 DroID_v2018_08 "Drer\ccdc82, Drer\qser1" - Cele\eor-2 - "Mmus\Prr12, Mmus\Qser1, Mmus\Ccdc82" "Hsap\QSER1, Hsap\PRR12, Hsap\CCDC82" "visible,partially lethal - majority die,some die during pupal stage" trichogen cell FBgn0266308 lncRNA:CR44973 - http://flybase.org/reports/FBgn0266308 non_protein_coding_gene - - - CR44973 - CR44973 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0001323 knrl knirps-like http://flybase.org/reports/FBgn0001323 - protein_coding_gene "zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR001628, InterPro:IPR013088 sequence-specific DNA binding ; GO:0043565 | inferred from electronic annotation with InterPro:IPR001628 transcription factor activity, sequence-specific DNA binding ; GO:0003700 | inferred from electronic annotation with InterPro:IPR001628" "open tracheal system development ; GO:0007424 | traceable author statement regulation of mitotic nuclear division ; GO:0007088 | inferred from mutant phenotype negative regulation of transcription, DNA-templated ; GO:0045892 | inferred from direct assay regulation of tube size, open tracheal system ; GO:0035151 | traceable author statement branched duct epithelial cell fate determination, open tracheal system ; GO:0046845 | traceable author statement epithelial cell migration, open tracheal system ; GO:0007427 | traceable author statement" nucleus ; GO:0005634 | inferred from electronic annotation with InterPro:IPR001628 "Knrl, NR0A2, CG4761, knrl, knl" "IPR001628:Zinc finger, nuclear hormone receptor-type, IPR013088:Zinc finger, NHR/GATA-type" CG4761 27-Aug-18 DroID_v2018_08 - - "Cele\nhr-119, Cele\nhr-3, Cele\nhr-85, Cele\nhr-7" - - Hsap\NR1H2 " embryonic stage | cellular blastoderm , embryonic stage , larval stage , embryonic stage | embryonic cycle 12 , larval stage | third instar , embryonic stage | 70% egg length , organism | 80-100% egg length & ventral

, wing vein L2 | precursor

,

ubiquitous , organism | 20-30% egg length

" "mitotic cell cycle defective,visible,viable" "dorsal closure embryo,embryonic dorsal epidermis,metathoracic femur,adult thorax & macrochaetaBx-MS1096" FBgn0263909 l(3)B57 - http://flybase.org/reports/FBgn0263909 gene - - - l(3)B57 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive,decreased cell number,somatic clone" "embryonic/larval brain,somatic clone" FBgn0045968 Tabor\pol Tabor element pol http://flybase.org/reports/FBgn0045968 transposable_element_gene - - - "ORF2, Pilgrim\pol, Tabor\pol" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0003309 sable sable http://flybase.org/reports/FBgn0003309 - gene - developmental pigmentation ; GO:0048066 | traceable author statement developmental pigmentation ; GO:0048066 | non-traceable author statement - "eb, s, sable" - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,recessive,body color defective,female sterile,viable,male,male fertile" "wing,scutellum,trident" FBgn0267928 lncRNA:CR46209 - http://flybase.org/reports/FBgn0267928 non_protein_coding_gene - - - "CR46209, lincRNA.196" - CR46209 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0067882 Mod(Prat:bw)1-5 Mod(Prat:bw)1-5 http://flybase.org/reports/FBgn0067882 gene - - - "Mod-1-5, Mod(Prat:bw)1-5" - - 27-Aug-18 DroID_v2018_08 - - - - - - enhancer of variegation FBgn0038965 mats mob as tumor suppressor http://flybase.org/reports/FBgn0038965 protein_coding_gene protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q9NBK5 protein kinase binding ; GO:0019901 | inferred from physical interaction with trc protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q9VA38 apoptotic process ; GO:0006915 | inferred from mutant phenotype chromosome segregation ; GO:0007059 | inferred from mutant phenotype signal transduction ; GO:0007165 | inferred from mutant phenotype ovarian follicle cell development ; GO:0030707 | inferred from mutant phenotype cell proliferation ; GO:0008283 | inferred from mutant phenotype mitotic spindle checkpoint ; GO:0071174 | NOT inferred from mutant phenotype multicellular organism development ; GO:0007275 | inferred from mutant phenotype plasma membrane ; GO:0005886 | inferred from direct assay centrosome ; GO:0005813 | inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay cytosol ; GO:0005829 | inferred from direct assay "CG13852, anon-WO0118547.303, mats, Mats, DMob1, dmob1, Dmob1, Mob1" IPR005301:MOB kinase activator family CG13852 27-Aug-18 DroID_v2018_08 "Drer\mob2b, Drer\mob3c, Drer\mob2a, Drer\mob3a, Drer\mob1a, Drer\mob1ba, Drer\LOC799520, Drer\mob1bb" "Scer\MOB1, Scer\MOB2" "Cele\F38H4.10, Cele\T12B3.4" "Xtro\mob2.1, Xtro\mob3a, Xtro\mob3c, Xtro\mob2.2, Xtro\mob1a, Xtro\mob1b, Xtro\mob3b" "Mmus\Mob1a, Mmus\Mob1b, Mmus\Mob3b, Mmus\Mob3c, Mmus\Mob2, Mmus\Mob3a" "Hsap\MOB3C, Hsap\MOB2, Hsap\MOB3B, Hsap\MOB3A, Hsap\MOB1B, Hsap\MOB1A" "neuroanatomy defective,somatic clone,tumorigenic,dominant,lethal - all die before end of second instar larval stage,recessive,some die during second instar larval stage,lethal,visible,body color defective,viable,wild-type,mitotic cell cycle defective" "imaginal disc,adult mushroom body,somatic clone,humerus,anepisternum,denticle,wing,wing hair,supernumerary,trichogen cell,mesothoracic tergum" DRSC14702 K 0.085228639 0.658521368 0.285839586 0.376705118 -0.522239165 3.279516468 FBgn0266777 lncRNA:CR45242 - http://flybase.org/reports/FBgn0266777 non_protein_coding_gene - - - CR45242 - CR45242 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0013932 E(DTW) E(DTW) http://flybase.org/reports/FBgn0013932 - gene - - - E(DTW) - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0085662 CG41517 - http://flybase.org/reports/FBgn0085662 protein_coding_gene - - - CG41517 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0031108 CG15459 - http://flybase.org/reports/FBgn0031108 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available mitochondrial proton-transporting ATP synthase complex ; GO:0005753 | inferred from biological aspect of ancestor with PANTHER:PTN002145699 CG15459 - CG15459 27-Aug-18 DroID_v2018_08 Drer\si:dkeyp-80c12.10 - - - Mmus\Usmg5 Hsap\USMG5 FBgn0262683 CG43153 - http://flybase.org/reports/FBgn0262683 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG43153, lincRNA.110" - CG43153 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0051014 PH4alphaSG1 prolyl-4-hydroxylase-alpha SG1 http://flybase.org/reports/FBgn0051014 protein_coding_gene "procollagen-proline 4-dioxygenase activity ; GO:0004656 | inferred from electronic annotation with InterPro:IPR013547 L-ascorbic acid binding ; GO:0031418 | inferred from electronic annotation with InterPro:IPR006620 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ; GO:0016702 | inferred from electronic annotation with InterPro:IPR013547 iron ion binding ; GO:0005506 | inferred from electronic annotation with InterPro:IPR006620" "oxidation-reduction process ; GO:0055114 | inferred from electronic annotation with InterPro:IPR005123, InterPro:IPR006620, InterPro:IPR013547 salivary gland morphogenesis ; GO:0007435 | inferred from mutant phenotype" endoplasmic reticulum ; GO:0005783 | inferred from direct assay "PHalphaSG1, CG15542, CG31014, PH4alphaSG1, SG1, Ph4alphaSG1, alphaSG1" "IPR005123:Oxoglutarate/iron-dependent dioxygenase, IPR006620:Prolyl 4-hydroxylase, alpha subunit, IPR013547:Prolyl 4-hydroxylase alpha-subunit, N-terminal, IPR011990:Tetratricopeptide-like helical domain" CG31014 27-Aug-18 DroID_v2018_08 "Drer\p4ha2, Drer\p4ha1b, Drer\zgc:158254, Drer\p4ha1a, Drer\p4ha3, Drer\p4htm, Drer\zgc:152670" - "Cele\phy-3, Cele\phy-4, Cele\phy-2, Cele\C14E2.4, Cele\dpy-18, Cele\Y43F8B.19" "Xtro\p4ha3, Xtro\p4ha1, Xtro\p4ha2" "Mmus\P4ha1, Mmus\P4ha3, Mmus\P4ha2, Mmus\P4htm" "Hsap\P4HA3, Hsap\P4HA2, Hsap\P4HTM, Hsap\P4HA1" viable FBgn0010563 l(2)04008 lethal (2) 04008 http://flybase.org/reports/FBgn0010563 - gene - - - l(2)04008 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0267204 lncRNA:CR45644 - http://flybase.org/reports/FBgn0267204 non_protein_coding_gene - - - CR45644 - CR45644 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0085479 CG34450 - http://flybase.org/reports/FBgn0085479 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG34450, CG32705, CG12136" - CG34450 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0005107 gustF gustatory-defective F http://flybase.org/reports/FBgn0005107 - gene - - - gustF - - 27-Aug-18 DroID_v2018_08 - - - - - - taste perception defective taste bristle FBgn0265300 lncRNA:CR44273 - http://flybase.org/reports/FBgn0265300 non_protein_coding_gene - - - CR44273 - CR44273 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0000013 abd abdominal http://flybase.org/reports/FBgn0000013 - gene - sensory organ development ; GO:0007423 | non-traceable author statement - "a-3, a(3)26, abd" - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,semidominant" "tergite,sternite" FBgn0036427 CG4613 - http://flybase.org/reports/FBgn0036427 protein_coding_gene "serine-type endopeptidase activity ; GO:0004252 | inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114 serine-type endopeptidase activity ; GO:0004252 | inferred from sequence model" "proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114 proteolysis ; GO:0006508 | inferred from sequence model" - "SP40, CG4613" "IPR001314:Peptidase S1A, chymotrypsin family, IPR001254:Serine proteases, trypsin domain, IPR018114:Serine proteases, trypsin family, histidine active site, IPR009003:Peptidase S1, PA clan, IPR033116:Serine proteases, trypsin family, serine active site" CG4613 27-Aug-18 DroID_v2018_08 "Drer\si:dkeyp-93a5.2, Drer\si:ch211-165b19.9, Drer\zgc:112368, Drer\tmprss3a, Drer\prss60.1, Drer\zgc:112038, Drer\prss60.3, Drer\zgc:112160, Drer\tmprss4b, Drer\si:ch211-165b19.5, Drer\gzma, Drer\zgc:153968, Drer\si:ch211-165b19.8, Drer\zgc:171592, Drer\try, Drer\LOC100004427, Drer\zgc:165423, Drer\gzm3, Drer\zgc:112302, Drer\zgc:123295, Drer\ela2l, Drer\zgc:92590, Drer\cfd, Drer\zgc:92313, Drer\LOC562139, Drer\zgc:154142, Drer\si:dkeyp-93a5.3, Drer\ctrl, Drer\prss60.2, Drer\si:dkey-16l2.17, Drer\zgc:92511, Drer\zgc:92041, Drer\zgc:163079, Drer\si:dkey-238d18.3, Drer\gzmk, Drer\ela3l, Drer\si:dkey-57c15.4, Drer\zgc:112285, Drer\zgc:92745, Drer\ela2, Drer\ctrb1, Drer\ovch1" - "Cele\try-6, Cele\try-1" "Xtro\tmprss3, Xtro\ctrb1, Xtro\prss29, Xtro\LOC100135144, Xtro\cela2a, Xtro\ctrb2, Xtro\cela3a" "Mmus\Tmprss3, Mmus\Ctrb1, Mmus\Cela3a, Mmus\Try10, Mmus\Hpn, Mmus\Try4, Mmus\Gm5771, Mmus\Ctrc, Mmus\Prss34, Mmus\Ctrl, Mmus\Cela1, Mmus\2210010C04Rik, Mmus\Klk15, Mmus\Cela3b, Mmus\Tmprss5, Mmus\Prss1, Mmus\Prss2, Mmus\Klk9, Mmus\Cela2a, Mmus\Gm10334, Mmus\Prss3, Mmus\Tmprss2" "Hsap\CTRC, Hsap\CELA3B, Hsap\CTRL, Hsap\KLK9, Hsap\HPN, Hsap\CELA1, Hsap\KLK15, Hsap\TMPRSS3, Hsap\CELA3A, Hsap\PRSS3, Hsap\TMPRSS5, Hsap\CELA2A, Hsap\CELA2B, Hsap\CTRB1, Hsap\PRSS1, Hsap\TMPRSS2, Hsap\CTRB2" viable FBgn0051213 CG31213 - http://flybase.org/reports/FBgn0051213 protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR017871 ATPase activity, coupled to transmembrane movement of substances ; GO:0042626 | inferred from biological aspect of ancestor with PANTHER:PTN000442469 ATPase activity, coupled to transmembrane movement of substances ; GO:0042626 | inferred from sequence or structural similarity with UniProtKB:O94911" lipid transport ; GO:0006869 | inferred from biological aspect of ancestor with PANTHER:PTN000442469 transport ; GO:0006810 | inferred from sequence or structural similarity with UniProtKB:O94911 integral component of membrane ; GO:0016021 | inferred from sequence or structural similarity with UniProtKB:Q9BZC7 intracellular membrane-bounded organelle ; GO:0043231 | inferred from biological aspect of ancestor with PANTHER:PTN000442469 "CG4794, CG11460, CG31213" "IPR027417:P-loop containing nucleoside triphosphate hydrolase, IPR003439:ABC transporter-like, IPR017871:ABC transporter, conserved site, IPR003593:AAA+ ATPase domain, IPR026082:ABC transporter A, ABCA" CG31213 27-Aug-18 DroID_v2018_08 "Drer\abch1, Drer\abca3b, Drer\abca2, Drer\abca12, Drer\abca5, Drer\abca1b, Drer\abca1a" - "Cele\abt-1, Cele\abt-4, Cele\ced-7, Cele\abt-2, Cele\abt-5" "Xtro\abca3, Xtro\abca4, Xtro\abca10, Xtro\abca1, Xtro\abca8, Xtro\abca9, Xtro\abca2" "Mmus\Abca16, Mmus\Abca8a, Mmus\Abca3, Mmus\Abca5, Mmus\Abca13, Mmus\Abca7, Mmus\Abca4, Mmus\Abca14, Mmus\Abca17, Mmus\Abca15, Mmus\Abca2, Mmus\Abca6, Mmus\Abca8b, Mmus\Abca12, Mmus\Abca9, Mmus\Abca1" "Hsap\ABCA13, Hsap\ABCA6, Hsap\ABCA5, Hsap\ABCA4, Hsap\ABCA2, Hsap\ABCA1, Hsap\ABCA7, Hsap\ABCA10, Hsap\ABCA9, Hsap\ABCA3, Hsap\ABCA12, Hsap\ABCA8" viable FBgn0265526 lncRNA:CR44376 - http://flybase.org/reports/FBgn0265526 non_protein_coding_gene - - - CR44376 - CR44376 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0265533 CR44383 - http://flybase.org/reports/FBgn0265533 pseudogene_attribute - - - CR44383 - CR44383 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0062258 SF-1 SF1 boundary element http://flybase.org/reports/FBgn0062258 insulator - - - "SF1, SF-1" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0004793 crpe crepe http://flybase.org/reports/FBgn0004793 - gene molecular_function ; GO:0003674 | no biological data available chorion-containing eggshell formation ; GO:0007304 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available crpe - - 27-Aug-18 DroID_v2018_08 - - - - - - female sterile FBgn0033498 CG12209 - http://flybase.org/reports/FBgn0033498 protein_coding_gene molecular_function ; GO:0003674 | no biological data available - cellular_component ; GO:0005575 | no biological data available "BcDNA:AT13439, CG12209" - CG12209 27-Aug-18 DroID_v2018_08 - Scer\BXI1 - - - - "visible,partially lethal - majority die,some die during pupal stage" trichogen cell FBgn0084000 CG41433 - http://flybase.org/reports/FBgn0084000 protein_coding_gene - - - CG41433 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0014311 l(3)ry105 lethal (3) ry105 http://flybase.org/reports/FBgn0014311 FBgn0015507 gene - - - "P622, l(3)ry105" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0266749 lncRNA:CR45222 - http://flybase.org/reports/FBgn0266749 non_protein_coding_gene - - - CR45222 - CR45222 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0013500 l(1)MA lethal (1) MA http://flybase.org/reports/FBgn0013500 - gene - - - l(1)MA - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0265962 lncRNA:CR44749 - http://flybase.org/reports/FBgn0265962 non_protein_coding_gene - - - CR44749 - CR44749 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0067786 anon-i176 anon-i176 http://flybase.org/reports/FBgn0067786 gene - - - "i176, anon-i176" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0039339 CG5116 - http://flybase.org/reports/FBgn0039339 protein_coding_gene "GTP binding ; GO:0005525 | inferred from electronic annotation with InterPro:IPR006073, InterPro:IPR016496, InterPro:IPR030394 ribosome binding ; GO:0043022 | inferred from biological aspect of ancestor with PANTHER:PTN000027640" - cytoplasm ; GO:0005737 | inferred from biological aspect of ancestor with PANTHER:PTN000027640 "CG5116, Dromel_CG5116_FBtr0084877_mORF" "IPR030394:HflX-type guanine nucleotide-binding (G) domain, IPR027417:P-loop containing nucleoside triphosphate hydrolase, IPR016496:GTPase HflX, IPR006073:GTP binding domain, IPR025121:GTPase HflX, N-terminal, IPR032305:GTP-binding protein, middle domain" CG5116 27-Aug-18 DroID_v2018_08 Drer\gtpbp6 - Cele\F46B6.4 Xtro\gtpbp6 Mmus\Gtpbp6 Hsap\GTPBP6 viable FBgn0052850 CG32850 - http://flybase.org/reports/FBgn0052850 protein_coding_gene zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR001841 ubiquitin-protein transferase activity ; GO:0004842 | inferred from sequence or structural similarity with HGNC:10056 ubiquitin protein ligase activity ; GO:0061630 | inferred from biological aspect of ancestor with PANTHER:PTN001021049 zinc ion binding ; GO:0008270 | inferred from sequence model protein autoubiquitination ; GO:0051865 | inferred from sequence or structural similarity with HGNC:10056 proteasome-mediated ubiquitin-dependent protein catabolic process ; GO:0043161 | inferred from biological aspect of ancestor with PANTHER:PTN001021049 protein ubiquitination involved in ubiquitin-dependent protein catabolic process ; GO:0042787 | inferred from sequence or structural similarity with HGNC:10056 ubiquitin ligase complex ; GO:0000151 | inferred from sequence or structural similarity with HGNC:10056 "BEST:GH26713, BcDNA:RE41137, CG32850, RNF-11" "IPR001841:Zinc finger, RING-type, IPR013083:Zinc finger, RING/FYVE/PHD-type" CG32850 27-Aug-18 DroID_v2018_08 "Drer\rnf126, Drer\rnf6, Drer\znrf3, Drer\rnf130, Drer\rnf111, Drer\rnf44, Drer\wu:fb39e10, Drer\rlim, Drer\pja2, Drer\rnf150a, Drer\rnf165b, Drer\si:ch211-81a5.1, Drer\rnf24, Drer\rnf11b, Drer\rnf32, Drer\si:dkey-51a16.9, Drer\rnf11a, Drer\zgc:175214, Drer\si:ch1073-392o20.1, Drer\rnf165a, Drer\rnf103, Drer\zswim2, Drer\rnf215, Drer\rnf150, Drer\rnf38, Drer\rnf115" "Scer\ASR1, Scer\YBR062C" "Cele\C01G6.4, Cele\eak-3" "Xtro\rnf44, Xtro\rnf111, Xtro\rnf11.2, Xtro\znrf3, Xtro\rnf126, Xtro\chmp3, Xtro\rnf38, Xtro\pja2, Xtro\rlim, Xtro\rnf115, Xtro\rnf24, Xtro\rnf11, Xtro\rnf181, Xtro\rnf149, Xtro\rnf32" "Mmus\Rnf181, Mmus\Rnf43, Mmus\Zswim2, Mmus\Znrf3, Mmus\Rnf24, Mmus\Rnf32, Mmus\Rnf115, Mmus\Rnf130, Mmus\Rnf126, Mmus\Rnf122, Mmus\Rnf149, Mmus\Rnf44, Mmus\Rnf38, Mmus\Rnf11, Mmus\Rnf111, Mmus\Rnf215, Mmus\Rnf165, Mmus\Rnf150, Mmus\Pja1, Mmus\Rlim, Mmus\Rnf6, Mmus\4930595M18Rik, Mmus\Pja2, Mmus\Rnf103" "Hsap\RNF32, Hsap\RNF215, Hsap\PJA1, Hsap\RNF149, Hsap\RNF181, Hsap\ZNRF3, Hsap\RNF111, Hsap\RLIM, Hsap\RNF24, Hsap\RNF43, Hsap\RNF115, Hsap\RNF165, Hsap\PJA2, Hsap\ZSWIM2, Hsap\RNF44, Hsap\RNF11, Hsap\RNF130, Hsap\RNF6, Hsap\CHMP3, Hsap\RNF38, Hsap\RNF122, Hsap\RNF103, Hsap\RNF126, Hsap\RNF150" "viable,fertile" FBgn0053758 CG33758 - http://flybase.org/reports/FBgn0053758 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG33758 IPR010512:Protein of unknown function DUF1091 CG33758 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0259654 B0960 - http://flybase.org/reports/FBgn0259654 gene - - - B0960 - - 27-Aug-18 DroID_v2018_08 - - - - - - visible "wing vein,wing,tarsal segment,unguis" FBgn0028879 CG15270 - http://flybase.org/reports/FBgn0028879 protein_coding_gene intracellular calcium activated chloride channel activity ; GO:0005229 | inferred from sequence or structural similarity with UniProtKB:Q9NW15 calcium activated cation channel activity ; GO:0005227 | inferred from sequence or structural similarity with HGNC:25519 chloride transport ; GO:0006821 | inferred from sequence or structural similarity with UniProtKB:Q9NW15 cation transport ; GO:0006812 | inferred from sequence or structural similarity with HGNC:25519 plasma membrane ; GO:0005886 | inferred from sequence or structural similarity with HGNC:25519 "BG:DS04929.1, CG15270" "IPR007632:Anoctamin, IPR015943:WD40/YVTN repeat-like-containing domain, IPR032675:Leucine-rich repeat domain, L domain-like" CG15270 27-Aug-18 DroID_v2018_08 "Drer\ano10a, Drer\ano10b, Drer\ano8b, Drer\ano8a, Drer\ano5a" Scer\IST2 "Cele\anoh-1, Cele\anoh-2" "Xtro\ano8, Xtro\ano10" "Mmus\Ano4, Mmus\Ano7, Mmus\Ano10, Mmus\Ano3, Mmus\Ano1, Mmus\Ano5, Mmus\Ano8" "Hsap\ANO5, Hsap\ANO10, Hsap\ANO8, Hsap\ANO4, Hsap\ANO7, Hsap\ANO1" viable FBgn0026669 l(1)G0129 lethal (1) G0129 http://flybase.org/reports/FBgn0026669 - gene - - - l(1)G0129 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive,lethal - all die before end of larval stage,some die during larval stage" FBgn0085319 CG34290 - http://flybase.org/reports/FBgn0085319 protein_coding_gene "serine-type endopeptidase activity ; GO:0004252 | inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114" "proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114" - CG34290 "IPR001314:Peptidase S1A, chymotrypsin family, IPR001254:Serine proteases, trypsin domain, IPR018114:Serine proteases, trypsin family, histidine active site, IPR009003:Peptidase S1, PA clan, IPR033116:Serine proteases, trypsin family, serine active site" CG34290 27-Aug-18 DroID_v2018_08 "Drer\LOC103908930, Drer\prss59.1, Drer\prss59.2, Drer\try, Drer\si:dkey-33m11.8, Drer\zgc:92590, Drer\LOC560023" - Cele\svh-1 "Xtro\LOC496746, Xtro\prss1, Xtro\prss1.2, Xtro\prss3, Xtro\try10, Xtro\prss2" "Mmus\Try10, Mmus\Prss1, Mmus\Prss2, Mmus\Gm2663, Mmus\1810009J06Rik, Mmus\Prss3, Mmus\Try5, Mmus\2210010C04Rik, Mmus\Gm10334, Mmus\Try4, Mmus\Gm5771" "Hsap\PRSS1, Hsap\PRSS3" FBgn0038603 PKD Protein Kinase D http://flybase.org/reports/FBgn0038603 protein_coding_gene "protein kinase C activity ; GO:0004697 | inferred from electronic annotation with InterPro:IPR015727 ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR015727, InterPro:IPR017441 protein serine/threonine kinase activity ; GO:0004674 | non-traceable author statement" "protein phosphorylation ; GO:0006468 | inferred from electronic annotation with InterPro:IPR000719, InterPro:IPR002290, InterPro:IPR008271, InterPro:IPR015727 regulation of glucose metabolic process ; GO:0010906 | inferred from mutant phenotype protein phosphorylation ; GO:0006468 | non-traceable author statement protein kinase D signaling ; GO:0089700 | inferred from biological aspect of ancestor with PANTHER:PTN000540182" cytoplasm ; GO:0005737 | inferred from direct assay "PKD, 150131_at, PKCm, CG7125, dPKD" "IPR000719:Protein kinase domain, IPR001849:Pleckstrin homology domain, IPR002219:Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, IPR008271:Serine/threonine-protein kinase, active site, IPR011009:Protein kinase-like domain, IPR011993:PH domain-like, IPR015727:Protein kinase C mu-related, IPR017441:Protein kinase, ATP binding site, IPR020454:Diacylglycerol/phorbol-ester binding" CG7125 27-Aug-18 DroID_v2018_08 "Drer\zgc:175248, Drer\LOC797974, Drer\prkd3, Drer\prkd1" Scer\CLA4 "Cele\F48G7.9, Cele\F48G7.10, Cele\R12G8.1, Cele\dkf-1, Cele\dkf-2" "Xtro\prkd1, Xtro\prkd3" "Mmus\Prkd3, Mmus\Prkd2, Mmus\Prkd1" "Hsap\PRKD1, Hsap\PRKD3, Hsap\PRKD2" viable FBgn0005512 l(2)25Bg lethal (2) 25Bg http://flybase.org/reports/FBgn0005512 - gene - - - "jf16, l(2)jf16, l(2)25Bg" - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0024884 l(2)03055 lethal (2) 03055 http://flybase.org/reports/FBgn0024884 - gene - - - "3055, l(2)03055" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0015485 l(2)46Ci lethal (2) 46Ci http://flybase.org/reports/FBgn0015485 FBgn0019715 gene - - - "M, 17.5, l(2)46CFm, l(2)46Ci" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive,lethal - all die before end of larval stage,some die during larval stage" FBgn0033815 CG4676 - http://flybase.org/reports/FBgn0033815 protein_coding_gene protein-cysteine S-palmitoyltransferase activity ; GO:0019706 | inferred from sequence or structural similarity with SGD:S000004236 protein palmitoylation ; GO:0018345 | inferred from sequence or structural similarity with SGD:S000004236 endoplasmic reticulum ; GO:0005783 | inferred from direct assay CG4676 "IPR001594:Palmitoyltransferase, DHHC domain" CG4676 27-Aug-18 DroID_v2018_08 "Drer\zdhhc1, Drer\zgc:77880, Drer\zdhhc21, Drer\zdhhc8b, Drer\zdhhc12b, Drer\zdhhc14, Drer\zdhhc9, Drer\zdhhc23a, Drer\zdhhc18a, Drer\zdhhc24, Drer\zdhhc3b, Drer\zdhhc7, Drer\zdhhc20b, Drer\LOC100334198, Drer\zdhhc5b, Drer\zdhhc12a, Drer\zdhhc22, Drer\zdhhc3a, Drer\zdhhc5a, Drer\zdhhc23b, Drer\zdhhc20a" "Scer\ERF2, Scer\PFA5" "Cele\dhhc-10, Cele\dhhc-12, Cele\dhhc-1, Cele\dhhc-9" "Xtro\zdhhc9, Xtro\zdhhc8, Xtro\zdhhc14, Xtro\zdhhc21, Xtro\zdhhc3, Xtro\zdhhc12, Xtro\dnz1, Xtro\zdhhc24, Xtro\zdhhc7, Xtro\zdhhc1" "Mmus\Zdhhc21, Mmus\Zdhhc11, Mmus\Zdhhc20, Mmus\Zdhhc12, Mmus\Zdhhc23, Mmus\Zdhhc3, Mmus\Zdhhc7, Mmus\Zdhhc22, Mmus\Zdhhc9, Mmus\Zdhhc8, Mmus\Zdhhc25, Mmus\Zdhhc24, Mmus\Zdhhc14, Mmus\Zdhhc19, Mmus\Zdhhc18, Mmus\Zdhhc5, Mmus\Zdhhc1" "Hsap\ZDHHC8, Hsap\ZDHHC19, Hsap\ZDHHC1, Hsap\ZDHHC11, Hsap\ZDHHC23, Hsap\ZDHHC7, Hsap\ZDHHC20, Hsap\ZDHHC14, Hsap\ZDHHC5, Hsap\ZDHHC9, Hsap\ZDHHC12, Hsap\ZDHHC24, Hsap\ZDHHC18, Hsap\ZDHHC3, Hsap\ZDHHC21, Hsap\ZDHHC22" viable FBgn0027546 CG4766 - http://flybase.org/reports/FBgn0027546 - protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "gh11415, BcDNA:GH11415, CG4766" "IPR024810:Mab-21 domain, IPR020950:Protein male abnormal 21-like 1/2" CG4766 27-Aug-18 DroID_v2018_08 "Drer\mab21l1, Drer\mb21d2, Drer\mab21l3, Drer\itprip, Drer\si:dkey-11f12.2, Drer\mab21l2, Drer\LOC556707, Drer\itpripl2" - Cele\mab-21 "Xtro\mb21d2, Xtro\mab21l1, Xtro\mab21l2" "Mmus\Itpripl1, Mmus\Mab21l3, Mmus\Itprip, Mmus\Mab21l2, Mmus\Itpripl2, Mmus\Tmem102, Mmus\Mb21d2, Mmus\Mb21d1, Mmus\2310007B03Rik, Mmus\Mab21l1" "Hsap\MAB21L3, Hsap\TMEM102, Hsap\ITPRIPL2, Hsap\MAB21L1, Hsap\MAB21L2, Hsap\ITPRIPL1, Hsap\ITPRIP, Hsap\MB21D1, Hsap\MB21D2, Hsap\C2orf54" viable FBgn0014271 l(2)k09619 lethal (2) k09619 http://flybase.org/reports/FBgn0014271 - gene - - - l(2)k09619 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" imaginal disc FBgn0260057 2L3937 - http://flybase.org/reports/FBgn0260057 gene - - - 2L3937 - - 27-Aug-18 DroID_v2018_08 - - - - - - "decreased cell size,somatic clone,lethal,recessive" "embryonic/larval tracheal system,somatic clone" FBgn0004852 Ac76E Adenylyl cyclase 76E http://flybase.org/reports/FBgn0004852 - protein_coding_gene guanylate cyclase activity ; GO:0004383 | inferred from biological aspect of ancestor with PANTHER:PTN000229249 adenylate cyclase activity ; GO:0004016 | non-traceable author statement adenylate cyclase activity ; GO:0004016 | inferred from direct assay "intracellular signal transduction ; GO:0035556 | inferred from electronic annotation with InterPro:IPR001054, InterPro:IPR018297 response to starvation ; GO:0042594 | inferred from direct assay instar larval or pupal development ; GO:0002165 | inferred from mutant phenotype signal transduction ; GO:0007165 | inferred from biological aspect of ancestor with PANTHER:PTN000228924 cAMP biosynthetic process ; GO:0006171 | inferred from direct assay negative regulation of multicellular organism growth ; GO:0040015 | inferred from mutant phenotype cGMP biosynthetic process ; GO:0006182 | inferred from biological aspect of ancestor with PANTHER:PTN000229249" "plasma membrane ; GO:0005886 | inferred from biological aspect of ancestor with PANTHER:PTN000228924 guanylate cyclase complex, soluble ; GO:0008074 | inferred from biological aspect of ancestor with PANTHER:PTN000229249" "CG7978, AC 76E, DAC76E, DAC2, Ac76E, ac76e, AC76E" "IPR001054:Adenylyl cyclase class-3/4/guanylyl cyclase, IPR018297:Adenylyl cyclase class-4/guanylyl cyclase, conserved site, IPR029787:Nucleotide cyclase, IPR032628:Adenylate cyclase, N-terminal" CG7978 27-Aug-18 DroID_v2018_08 "Drer\adcy2b, Drer\adcy1a, Drer\adcy7, Drer\adcy2a, Drer\adcy1b, Drer\adcy6b, Drer\adcy3a, Drer\adcy8, Drer\adcy6a, Drer\adcy5, Drer\si:dkey-206f10.1, Drer\si:ch211-132f19.7" - "Cele\acy-2, Cele\acy-4" "Xtro\dnajc27, Xtro\adcy1, Xtro\adcy6, Xtro\adcy4, Xtro\adcy7" "Mmus\Adcy5, Mmus\Adcy2, Mmus\Adcy7, Mmus\Adcy6, Mmus\Adcy3, Mmus\Adcy4, Mmus\Adcy8, Mmus\Adcy1" "Hsap\ADCY1, Hsap\ADCY8, Hsap\ADCY3, Hsap\ADCY7, Hsap\ADCY5, Hsap\ADCY6, Hsap\ADCY2, Hsap\ADCY4" "developmental rate defective,body size defective,starvation stress response defective,female limited" FBgn0010072 Mab66B2 Monoclonal antibody 66B2 http://flybase.org/reports/FBgn0010072 - gene - - - Mab66B2 - - 27-Aug-18 DroID_v2018_08 - - - - - - " larval stage , embryonic stage | 12-15 hr , pupal stage , embryonic stage " " imaginal disc

, embryonic/larval hindgut

, optic lobe

, epidermis

, neuropil

, central nervous system

, embryonic/larval foregut

, embryonic/larval trachea

, Keilin's organ

" FBgn0039876 CG2126 - http://flybase.org/reports/FBgn0039876 protein_coding_gene ubiquitin protein ligase binding ; GO:0031625 | inferred from sequence or structural similarity with HGNC:20184 ER-associated ubiquitin-dependent protein catabolic process ; GO:0030433 | inferred from sequence or structural similarity with HGNC:20184 cellular_component ; GO:0005575 | no biological data available "anon-WO0118547.412, CG2126" IPR008485:Protein of unknown function DUF766 CG2126 27-Aug-18 DroID_v2018_08 Drer\jkamp - Cele\jamp-1 Xtro\jkamp "Mmus\4931417E11Rik, Mmus\Jkamp" Hsap\JKAMP viable DRSC15418 E 0.863364304 0.056081719 -0.335910605 -2.634622219 1.088719498 -1.103259431 FBgn0022089 l(2)k07315 lethal (2) k07315 http://flybase.org/reports/FBgn0022089 - gene - - - l(2)k07315 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0005087 fs(2)OW811 female sterile (2) OW811 http://flybase.org/reports/FBgn0005087 - gene - - - fs(2)OW811 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0061483 rover\gag rover element gag http://flybase.org/reports/FBgn0061483 transposable_element_gene - - - rover\gag - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0000933 fs(2)A3 female sterile (2) A3 http://flybase.org/reports/FBgn0000933 - gene - - - fs(2)A3 - - 27-Aug-18 DroID_v2018_08 - - - - - - "female sterile,recessive" female reproductive system FBgn0032562 CG18483 - http://flybase.org/reports/FBgn0032562 protein_coding_gene - - - "Ms(2)35Ci, BG:DS07851.10, CG18483" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0013484 l(1)4Fb lethal (1) 4Fb http://flybase.org/reports/FBgn0013484 - gene - - - l(1)4Fb - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0065372 l(2)SH1694 lethal (2) SH1694 http://flybase.org/reports/FBgn0065372 gene - - - "l(2)SH1694, l(2)SH2 1694" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0004758 l(3)89Bk lethal (3) 89Bk http://flybase.org/reports/FBgn0004758 - gene - - - l(3)89Bk - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0014148 dkn deathknell http://flybase.org/reports/FBgn0014148 - gene - - - dkn - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0041091 ubi-d4 ubi-d4 http://flybase.org/reports/FBgn0041091 gene - - - ubi-d4 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0001508 l(1)10Fb lethal (1) 10Fb http://flybase.org/reports/FBgn0001508 - gene - - - l(1)10Fb - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of larval stage,recessive,some die during larval stage" "ovariole,germline clone,egg" FBgn0013516 l(1)XWJ lethal (1) XWJ http://flybase.org/reports/FBgn0013516 - gene - - - "XWJ, l(1)XWJ" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0001916 l(2)25Bc lethal (2) 25Bc http://flybase.org/reports/FBgn0001916 - gene - - - "jf12, l(2)jf12, l(2)25Bc" - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0000753 fs(1)A426 female sterile (1) A426 http://flybase.org/reports/FBgn0000753 - gene - - - fs(1)A426 - - 27-Aug-18 DroID_v2018_08 - - - - - - "female sterile,recessive,heat sensitive,lethal - all die before end of embryonic stage,non-rescuable maternal effect,some die during embryonic stage" embryo FBgn0035388 CG2162 - http://flybase.org/reports/FBgn0035388 protein_coding_gene nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR001374 - exon-exon junction complex ; GO:0035145 | inferred from biological aspect of ancestor with PANTHER:PTN000495129 "anon-EST:Posey170, CG2162" "IPR001374:R3H domain, IPR000504:RNA recognition motif domain" CG2162 27-Aug-18 DroID_v2018_08 "Drer\r3hcc1, Drer\r3hcc1l" - Cele\F09C8.2 - "Mmus\R3hcc1, Mmus\R3hcc1l" "Hsap\R3HCC1, Hsap\R3HCC1L" "viable,fertile,lethal - all die before end of pupal stage,some die during pupal stage" DRSC08557 I -0.995653385 -1.829900572 -0.127522695 -0.161080206 0.227530834 0.257245196 FBgn0003384 shakA shaking A http://flybase.org/reports/FBgn0003384 - gene - - - shakA - - 27-Aug-18 DroID_v2018_08 - - - - - - "hyperactive,courtship behavior defective,heat sensitive,jumping defective,flight defective,uncoordinated,hypoactive" FBgn0053339 CG33339 - http://flybase.org/reports/FBgn0053339 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG13612, CG33339" IPR006631:Protein of unknown function DM4/12 CG33339 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0086883 Pab Pale body http://flybase.org/reports/FBgn0086883 gene - - - Pab - - 27-Aug-18 DroID_v2018_08 - - - - - - "body color defective,dominant,lethal,recessive" "adult cuticle,antenna,tergite" FBgn0036747 CG6052 - http://flybase.org/reports/FBgn0036747 protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR017871 ATPase activity, coupled to transmembrane movement of substances ; GO:0042626 | inferred from sequence or structural similarity with UniProtKB:O94911 ATPase activity, coupled to transmembrane movement of substances ; GO:0042626 | inferred from biological aspect of ancestor with PANTHER:PTN000442469" transport ; GO:0006810 | inferred from sequence or structural similarity with UniProtKB:O94911 lipid transport ; GO:0006869 | inferred from biological aspect of ancestor with PANTHER:PTN000442469 intracellular membrane-bounded organelle ; GO:0043231 | inferred from biological aspect of ancestor with PANTHER:PTN000442469 integral component of membrane ; GO:0016021 | inferred from sequence or structural similarity with UniProtKB:Q9BZC7 CG6052 "IPR003439:ABC transporter-like, IPR003593:AAA+ ATPase domain, IPR027417:P-loop containing nucleoside triphosphate hydrolase, IPR017871:ABC transporter, conserved site, IPR026082:ABC transporter A, ABCA" CG6052 27-Aug-18 DroID_v2018_08 "Drer\abca1b, Drer\abca5, Drer\abca2, Drer\abch1, Drer\abca12, Drer\abca1a, Drer\abca3b" "Scer\SNQ2, Scer\PDR15, Scer\PDR10, Scer\CAF16, Scer\PDR5, Scer\PDR18, Scer\YOL075C, Scer\AUS1, Scer\PDR12, Scer\PDR11" "Cele\abt-4, Cele\ced-7, Cele\abt-2, Cele\abt-5" "Xtro\abca9, Xtro\abca2, Xtro\abca10, Xtro\abca3, Xtro\abca1, Xtro\abca4, Xtro\abca8" "Mmus\Abca3, Mmus\Abca13, Mmus\Abca9, Mmus\Abca8b, Mmus\Abca12, Mmus\Abca17, Mmus\Abca2, Mmus\Abca5, Mmus\Abca7, Mmus\Abca16, Mmus\Abca8a, Mmus\Abca6, Mmus\Abca14, Mmus\Abca1, Mmus\Abca4, Mmus\Abca15" "Hsap\ABCA12, Hsap\ABCA7, Hsap\ABCA2, Hsap\ABCA6, Hsap\ABCA8, Hsap\ABCA1, Hsap\ABCA13, Hsap\ABCA5, Hsap\ABCA10, Hsap\ABCA4, Hsap\ABCA3, Hsap\ABCA9" viable FBgn0013322 Pcp82 Pupal-cuticle-protein-82kD http://flybase.org/reports/FBgn0013322 - gene - - - Pcp82 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0037976 Tk Tachykinin http://flybase.org/reports/FBgn0037976 protein_coding_gene tachykinin receptor binding ; GO:0071861 | inferred from physical interaction with TkR86C neuropeptide hormone activity ; GO:0005184 | inferred from sequence or structural similarity receptor binding ; GO:0005102 | non-traceable author statement tachykinin receptor binding ; GO:0071861 | inferred from physical interaction with TkR99D adult walking behavior ; GO:0007628 | inferred from mutant phenotype sensory perception of smell ; GO:0007608 | inferred from mutant phenotype tachykinin receptor signaling pathway ; GO:0007217 | inferred from direct assay positive regulation of sensory perception of pain ; GO:1904058 | inferred from mutant phenotype inter-male aggressive behavior ; GO:0002121 | inferred from mutant phenotype neuropeptide signaling pathway ; GO:0007218 | inferred from sequence or structural similarity response to pheromone ; GO:0019236 | inferred from mutant phenotype lipid metabolic process ; GO:0006629 | inferred from mutant phenotype extracellular space ; GO:0005615 | inferred by curator from GO:0071861 extracellular space ; GO:0005615 | inferred from direct assay "DTK1, Drm-TK-3, CG14734, Drm-TK-6, Drm-TK-5, Drm-TK-4, Drm-TK-2, Drm-TK-1, Drm-TK, Dtk, Tk, dtk, DTK, Tyk, TK-1, TK, DTK-6, DTK-3, DTK-2, DTK-5, DTK-1, DTK-4, TAP-5, DmTK6, dTK, Tachykinin 1, Tachykinin 2, Tachykinin 4, Tachykinin 5" - CG14734 27-Aug-18 DroID_v2018_08 Drer\tac1 - - Xtro\tac1 Mmus\Tac1 Hsap\TAC1 "viable,fertile,behavior defective,recessive,lethal - all die before end of embryonic stage,some die during embryonic stage,smell perception defective,locomotor behavior defective,female" FBgn0000421 displaced displaced http://flybase.org/reports/FBgn0000421 - gene - - - "dd, displaced" - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,female sterile" "antenna,adult head,eye" FBgn0267710 lncRNA:CR46043 - http://flybase.org/reports/FBgn0267710 non_protein_coding_gene - - - CR46043 - CR46043 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0031058 CG14227 - http://flybase.org/reports/FBgn0031058 protein_coding_gene "serine-type endopeptidase activity ; GO:0004252 | inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114 serine-type endopeptidase activity ; GO:0004252 | NOT non-traceable author statement" "proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114" - "SPH158, CG14227" "IPR001254:Serine proteases, trypsin domain, IPR009003:Peptidase S1, PA clan, IPR001314:Peptidase S1A, chymotrypsin family, IPR018114:Serine proteases, trypsin family, histidine active site" CG14227 27-Aug-18 DroID_v2018_08 - - Cele\try-3 - "Mmus\Tpsab1, Mmus\Prss28, Mmus\Prss30, Mmus\Klk8, Mmus\Prss29, Mmus\Klk14, Mmus\Tpsb2, Mmus\Klk7, Mmus\Prss33, Mmus\Klk5, Mmus\Prss48, Mmus\Klk4, Mmus\Prss32, Mmus\Prss46, Mmus\Klk10, Mmus\F12, Mmus\Tpsg1, Mmus\Prss34, Mmus\Klk12, Mmus\Prss21, Mmus\Hgfac" "Hsap\F12, Hsap\TPSAB1, Hsap\TPSD1, Hsap\HGFAC, Hsap\PRSS48, Hsap\KLK8, Hsap\KLK4, Hsap\KLK5, Hsap\TPSG1, Hsap\KLK10, Hsap\KLK14, Hsap\PRSS33, Hsap\KLK12, Hsap\TPSB2, Hsap\PRSS21, Hsap\KLK7" FBgn0031936 CG13794 - http://flybase.org/reports/FBgn0031936 protein_coding_gene neurotransmitter:sodium symporter activity ; GO:0005328 | inferred from electronic annotation with InterPro:IPR000175 transporter activity ; GO:0005215 | inferred from biological aspect of ancestor with PANTHER:PTN000177662 neurotransmitter:sodium symporter activity ; GO:0005328 | inferred from sequence model neurotransmitter transporter activity ; GO:0005326 | inferred from sequence or structural similarity with DAT neurotransmitter transport ; GO:0006836 | inferred from sequence model transport ; GO:0006810 | inferred from biological aspect of ancestor with PANTHER:PTN000177662 neurotransmitter transport ; GO:0006836 | inferred from sequence or structural similarity with DAT integral component of plasma membrane ; GO:0005887 | inferred from biological aspect of ancestor with PANTHER:PTN000177662 integral component of membrane ; GO:0016021 | inferred from sequence model CG13794 IPR000175:Sodium:neurotransmitter symporter CG13794 27-Aug-18 DroID_v2018_08 Drer\zgc:158225 - "Cele\snf-6, Cele\snf-10" - "Mmus\Slc6a3, Mmus\Slc6a7" "Hsap\SLC6A14, Hsap\SLC6A7" viable FBgn0047330 CG32235 - http://flybase.org/reports/FBgn0047330 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "BcDNA:AT25643, CG32235" - CG32235 27-Aug-18 DroID_v2018_08 - - - - - - "partially lethal - majority die,some die during pupal stage,viable" FBgn0011083 l(1)Q41 lethal (1) Q41 http://flybase.org/reports/FBgn0011083 FBgn0010210 gene - - - l(1)Q41 - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0039025 Usp12-46 Ubiquitin-specific protease 12/46 http://flybase.org/reports/FBgn0039025 protein_coding_gene thiol-dependent ubiquitin-specific protease activity ; GO:0004843 | inferred from sequence or structural similarity with HGNC:20485 ubiquitin-dependent protein catabolic process ; GO:0006511 | inferred from electronic annotation with InterPro:IPR018200 protein deubiquitination ; GO:0016579 | inferred from sequence or structural similarity with HGNC:20485 negative regulation of Notch signaling pathway ; GO:0045746 | inferred from mutant phenotype inferred from genetic interaction with N inferred from genetic interaction with spdo cellular_component ; GO:0005575 | no biological data available "CG7023, Usp12-46, Q9VCT9, Usp12, Usp12/46" "IPR001394:Peptidase C19, ubiquitin carboxyl-terminal hydrolase, IPR018200:Ubiquitin specific protease, conserved site, IPR028889:Ubiquitin specific protease domain" CG7023 27-Aug-18 DroID_v2018_08 "Drer\usp1, Drer\usp12a, Drer\usp12b, Drer\usp38, Drer\usp46" "Scer\UBP13, Scer\UBP9" Cele\usp-46 "Xtro\usp1, Xtro\usp46, Xtro\usp35, Xtro\hapln3" "Mmus\Usp38, Mmus\Usp35, Mmus\Usp1, Mmus\Usp12, Mmus\Usp46" "Hsap\USP12, Hsap\USP46, Hsap\USP1, Hsap\USP38, Hsap\USP35" viable "mesothoracic tergum,socket,eo sensory structure" FBgn0001629 l(1)dn6 lethal (1) discs normal 6 http://flybase.org/reports/FBgn0001629 - gene - - - "l(1)d.norm.-6, l(1)dn6" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of pupal stage,some die during pupal stage" FBgn0033871 CG13339 - http://flybase.org/reports/FBgn0033871 protein_coding_gene - - - "BcDNA:RE69336, CG13339" - CG13339 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0046886 Gr98c Gustatory receptor 98c http://flybase.org/reports/FBgn0046886 protein_coding_gene olfactory receptor activity ; GO:0004984 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 sweet taste receptor activity ; GO:0033041 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 sensory perception of bitter taste ; GO:0050913 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 male courtship behavior ; GO:0008049 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 sensory perception of pain ; GO:0019233 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 chemosensory behavior ; GO:0007635 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 response to carbon dioxide ; GO:0010037 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 integral component of membrane ; GO:0016021 | inferred from electronic annotation with InterPro:IPR013604 dendrite ; GO:0030425 | inferred from biological aspect of ancestor with PANTHER:PTN000475107 integral component of membrane ; GO:0016021 | non-traceable author statement axon ; GO:0030424 | inferred from biological aspect of ancestor with PANTHER:PTN000475107 neuronal cell body ; GO:0043025 | inferred from biological aspect of ancestor with PANTHER:PTN000475107 "Gr98A1, CG12884, Gr98B3, Gr98A2, 98B.3, GR98B.3, CG31060, Gr98c, GR98c" IPR013604:7TM chemoreceptor CG31060 27-Aug-18 DroID_v2018_08 - - "Cele\gur-3, Cele\lite-1" - - - viable FBgn0029720 CG3009 - http://flybase.org/reports/FBgn0029720 protein_coding_gene phospholipase A2 activity ; GO:0004623 | inferred from electronic annotation with InterPro:IPR016090 arachidonic acid secretion ; GO:0050482 | inferred from electronic annotation with InterPro:IPR016090 phospholipid metabolic process ; GO:0006644 | inferred from electronic annotation with InterPro:IPR016090 - CG3009 "IPR016090:Phospholipase A2 domain, IPR033113:Phospholipase A2, histidine active site" CG3009 27-Aug-18 DroID_v2018_08 "Drer\proca1, Drer\LOC101885160, Drer\zgc:123275" - - Xtro\proca1 "Mmus\Proca1, Mmus\Pla2g3" "Hsap\PLA2G3, Hsap\PROCA1" "viable,fertile" FBgn0267346 T:FK506-bp2 - http://flybase.org/reports/FBgn0267346 engineered_tag - - - T:FK506-bp2 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0261812 CG42754 - http://flybase.org/reports/FBgn0261812 protein_coding_gene - - - CG42754 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0045486 Gr36b Gustatory receptor 36b http://flybase.org/reports/FBgn0045486 protein_coding_gene olfactory receptor activity ; GO:0004984 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 taste receptor activity ; GO:0008527 | non-traceable author statement sweet taste receptor activity ; GO:0033041 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 sensory perception of pain ; GO:0019233 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 sensory perception of bitter taste ; GO:0050913 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 male courtship behavior ; GO:0008049 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 response to carbon dioxide ; GO:0010037 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 chemosensory behavior ; GO:0007635 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 sensory perception of taste ; GO:0050909 | non-traceable author statement integral component of membrane ; GO:0016021 | inferred from electronic annotation with InterPro:IPR013604 dendrite ; GO:0030425 | inferred from biological aspect of ancestor with PANTHER:PTN000475107 axon ; GO:0030424 | inferred from biological aspect of ancestor with PANTHER:PTN000475107 integral component of membrane ; GO:0016021 | non-traceable author statement neuronal cell body ; GO:0043025 | inferred from biological aspect of ancestor with PANTHER:PTN000475107 "Gr36B.2, CG15137, Gr36B2, CG31744, Gr36b, GR36b" IPR013604:7TM chemoreceptor CG31744 27-Aug-18 DroID_v2018_08 - - "Cele\lite-1, Cele\gur-3" - - - viable FBgn0001187 Hex-C Hexokinase C http://flybase.org/reports/FBgn0001187 FBgn0034003 protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR001312, InterPro:IPR022672, InterPro:IPR022673 glucose binding ; GO:0005536 | inferred from electronic annotation with InterPro:IPR001312 mannokinase activity ; GO:0019158 | inferred from biological aspect of ancestor with PANTHER:PTN000455350 fructokinase activity ; GO:0008865 | inferred from biological aspect of ancestor with PANTHER:PTN000455350 hexokinase activity ; GO:0004396 | inferred from direct assay glucokinase activity ; GO:0004340 | inferred from biological aspect of ancestor with PANTHER:PTN000455350" carbohydrate phosphorylation ; GO:0046835 | inferred from electronic annotation with InterPro:IPR001312 glycolytic process ; GO:0006096 | inferred from biological aspect of ancestor with PANTHER:PTN000455350 lateral inhibition ; GO:0046331 | inferred from mutant phenotype cellular glucose homeostasis ; GO:0001678 | inferred from biological aspect of ancestor with PANTHER:PTN000455350 regulation of glucose metabolic process ; GO:0010906 | inferred from mutant phenotype cytosol ; GO:0005829 | inferred from biological aspect of ancestor with PANTHER:PTN000455350 "Hex-C, CT22069, HK, DM2, CG8094, HEX, Hk, HEX-C, Hex-c, Hex, HEX-3, Hex-3, Fk, HK-C, HexC" "IPR001312:Hexokinase, IPR022672:Hexokinase, N-terminal, IPR022673:Hexokinase, C-terminal" CG8094 27-Aug-18 DroID_v2018_08 "Drer\hkdc1, Drer\gck, Drer\hk2, Drer\hk1" "Scer\EMI2, Scer\HXK1, Scer\HXK2, Scer\GLK1, Scer\YLR446W" "Cele\hxk-2, Cele\hxk-3, Cele\hxk-1" "Xtro\hk2, Xtro\gck, Xtro\hk1" "Mmus\Gck, Mmus\Hk3, Mmus\Hkdc1, Mmus\Hk2, Mmus\Hk1" "Hsap\HKDC1, Hsap\HK1, Hsap\HK2, Hsap\GCK, Hsap\HK3" "electrophoretic variant,viable,visible" "chaeta,trichogen cell,supernumerary,tormogen cell" FBgn0039625 beta4GalNAcTB beta4GalNAcTB http://flybase.org/reports/FBgn0039625 protein_coding_gene "beta-1,4-N-acetylgalactosaminyltransferase activity ; GO:0033207 | inferred from direct assay N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity ; GO:0033842 | inferred from direct assay acetylgalactosaminyltransferase activity ; GO:0008376 | inferred from direct assay" carbohydrate metabolic process ; GO:0005975 | inferred from electronic annotation with InterPro:IPR003859 glycolipid biosynthetic process ; GO:0009247 | inferred from direct assay N-acetylglucosamine metabolic process ; GO:0006044 | inferred from direct assay glycosphingolipid biosynthetic process ; GO:0006688 | inferred from mutant phenotype Golgi apparatus ; GO:0005794 | inferred from direct assay "CG14517, dbeta4GalTB, beta4GalTB, beta4GalNAcTB" "IPR003859:Beta-1,4-galactosyltransferase, IPR029044:Nucleotide-diphospho-sugar transferases, IPR027995:Galactosyltransferase, N-terminal, IPR027791:Galactosyltransferase, C-terminal" CG14517 27-Aug-18 DroID_v2018_08 "Drer\b4galt1l, Drer\b4galt5, Drer\b4galt3, Drer\si:dkey-199f5.8, Drer\b4galt2, Drer\b4galt4, Drer\b4galt1, Drer\b4galt6" Scer\TMA20 Cele\bre-4 "Xtro\b4galt1.2, Xtro\LOC100485024, Xtro\b4galt1.1, Xtro\b4galt6, Xtro\b4galt3, Xtro\b4galt5, Xtro\b4galt2, Xtro\b4galt4" "Mmus\B4galt1, Mmus\B4galt4, Mmus\B4galt3, Mmus\B4galt2, Mmus\B4galt5, Mmus\B4galt6" "Hsap\B4GALT4, Hsap\B4GALT2, Hsap\B4GALT5, Hsap\B4GALT3, Hsap\B4GALT6, Hsap\B4GALT1" "viable,fertile" FBgn0070011 BG01296 BG01296 http://flybase.org/reports/FBgn0070011 gene - - - BG01296 - - 27-Aug-18 DroID_v2018_08 - - - - - - stress response defective FBgn0037688 CG9356 - http://flybase.org/reports/FBgn0037688 protein_coding_gene - Golgi to plasma membrane protein transport ; GO:0043001 | inferred from electronic annotation with InterPro:IPR027095 Golgi organization ; GO:0007030 | inferred from electronic annotation with InterPro:IPR027095 - "CG9356, Golgin-45" IPR027095:Golgin-45 CG9356 27-Aug-18 DroID_v2018_08 Drer\blzf1 - Cele\R12B2.2 Xtro\blzf1 Mmus\Blzf1 Hsap\BLZF1 FBgn0036937 Ir76b Ionotropic receptor 76b http://flybase.org/reports/FBgn0036937 protein_coding_gene ionotropic glutamate receptor activity ; GO:0004970 | inferred from electronic annotation with InterPro:IPR001320 sodium channel activity ; GO:0005272 | inferred from direct assay salty taste receptor activity ; GO:0033039 | inferred from mutant phenotype olfactory receptor activity ; GO:0004984 | contributes_to inferred from direct assay ligand-gated ion channel activity ; GO:0015276 | inferred from sequence model transmission of nerve impulse ; GO:0019226 | inferred from mutant phenotype cellular response to salt ; GO:1902075 | inferred from mutant phenotype detection of chemical stimulus involved in sensory perception of smell ; GO:0050911 | inferred from direct assay detection of chemical stimulus ; GO:0009593 | inferred from sequence or structural similarity with Ir92a salt aversion ; GO:0035199 | NOT inferred from mutant phenotype membrane ; GO:0016020 | inferred from electronic annotation with InterPro:IPR001320 sensory dendrite ; GO:0071683 | inferred from direct assay receptor complex ; GO:0043235 | inferred from direct assay integral component of membrane ; GO:0016021 | inferred from sequence model "Ir76b, CT22733, IR76b, CG7385, DmelIR76b, ir76b" IPR001320:Ionotropic glutamate receptor CG7385 27-Aug-18 DroID_v2018_08 - - - - - - "neurophysiology defective,chemosensitive behavior defective,viable" "L-type sensilla L6,L-type sensilla L4,L-type sensilla L2" FBgn0265422 lncRNA:CR44334 - http://flybase.org/reports/FBgn0265422 non_protein_coding_gene - - - CR44334 - CR44334 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0046117 E(To)9 E(To)9 http://flybase.org/reports/FBgn0046117 gene - - - E(To)9 - - 27-Aug-18 DroID_v2018_08 - - - - - - "sterile,recessive,viable,visible" "dorsal appendage,eye,wing margin" FBgn0265640 lncRNA:CR44447 - http://flybase.org/reports/FBgn0265640 non_protein_coding_gene - - - CR44447 - CR44447 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0263031 CG43326 - http://flybase.org/reports/FBgn0263031 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG13514, CG30217, CG43326" IPR006629:LPS-induced tumour necrosis factor alpha factor CG43326 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0040787 CG12518 - http://flybase.org/reports/FBgn0040787 protein_coding_gene - - - CG12518 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0022088 l(2)k07332 lethal (2) k07332 http://flybase.org/reports/FBgn0022088 - gene - - - l(2)k07332 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0002911 mwg micro-wing http://flybase.org/reports/FBgn0002911 - gene - - - mwg - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,fertile,viable" "wing,haltere" FBgn0084004 CG41437 - http://flybase.org/reports/FBgn0084004 protein_coding_gene - - - CG41437 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0062564 P10 P10 http://flybase.org/reports/FBgn0062564 gene - - - P10 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0022110 l(2)k06918 lethal (2) k06918 http://flybase.org/reports/FBgn0022110 - gene - - - l(2)k06918 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0039779 PH4alphaSG2 prolyl-4-hydroxylase-alpha SG2 http://flybase.org/reports/FBgn0039779 protein_coding_gene "procollagen-proline 4-dioxygenase activity ; GO:0004656 | inferred from electronic annotation with InterPro:IPR013547 L-ascorbic acid binding ; GO:0031418 | inferred from electronic annotation with InterPro:IPR006620 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen ; GO:0016702 | inferred from electronic annotation with InterPro:IPR013547 iron ion binding ; GO:0005506 | inferred from electronic annotation with InterPro:IPR006620" "oxidation-reduction process ; GO:0055114 | inferred from electronic annotation with InterPro:IPR005123, InterPro:IPR006620, InterPro:IPR013547 salivary gland morphogenesis ; GO:0007435 | inferred from mutant phenotype" endoplasmic reticulum ; GO:0005783 | inferred from direct assay "CG1546, PH4alphaSG2, SG2" "IPR005123:Oxoglutarate/iron-dependent dioxygenase, IPR006620:Prolyl 4-hydroxylase, alpha subunit, IPR011990:Tetratricopeptide-like helical domain, IPR013547:Prolyl 4-hydroxylase alpha-subunit, N-terminal" CG1546 27-Aug-18 DroID_v2018_08 "Drer\p4ha2, Drer\p4ha1b, Drer\p4ha1a, Drer\p4ha3, Drer\zgc:158254, Drer\p4htm, Drer\zgc:152670" - "Cele\phy-2, Cele\phy-4, Cele\C14E2.4, Cele\Y43F8B.19, Cele\dpy-18, Cele\phy-3" "Xtro\p4ha1, Xtro\p4ha2, Xtro\p4ha3" "Mmus\P4ha1, Mmus\P4ha3, Mmus\P4htm, Mmus\P4ha2" "Hsap\P4HA3, Hsap\P4HA1, Hsap\P4HA2, Hsap\P4HTM" viable FBgn0036489 CG7011 - http://flybase.org/reports/FBgn0036489 protein_coding_gene molecular_function ; GO:0003674 | no biological data available ER to Golgi vesicle-mediated transport ; GO:0006888 | inferred from sequence or structural similarity with SGD:S000000040 - CG7011 "IPR012936:Endoplasmic reticulum vesicle transporter, C-terminal" CG7011 27-Aug-18 DroID_v2018_08 "Drer\si:ch211-225b10.3, Drer\ergic1, Drer\ergic3, Drer\ergic2" "Scer\ERV41, Scer\ERV46" Cele\erv-46 "Xtro\ergic3, Xtro\ergic1, Xtro\ergic2" "Mmus\Ergic3, Mmus\Ergic2, Mmus\Ergic1" "Hsap\ERGIC1, Hsap\ERGIC3, Hsap\ERGIC2" viable FBgn0260630 f06222 - http://flybase.org/reports/FBgn0260630 gene - - - f06222 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0045860 crle crippled leg http://flybase.org/reports/FBgn0045860 gene - - - crle - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0004078 Ars-region13 Autonomous replicating sequence region 13 http://flybase.org/reports/FBgn0004078 - region - - - "Ars-region13, Ars13" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0286198 LKRSDH Lysine ketoglutarate reductase/saccharopine dehydrogenase http://flybase.org/reports/FBgn0025687 "FBgn0031949, FBgn0045950" protein_coding_gene oxidoreductase activity ; GO:0016491 | inferred from electronic annotation with InterPro:IPR005097 oxidation-reduction process ; GO:0055114 | inferred from electronic annotation with InterPro:IPR005097 regulation of histone methylation ; GO:0031060 | inferred from direct assay histone arginine methylation ; GO:0034969 | inferred from direct assay - "CG7144, BEST:CK02318, CK02318, anon-WO0149856.1, LKRSDH, LKR, dLKR, SDH" "IPR005097:Saccharopine dehydrogenase, NADP binding domain, IPR007698:Alanine dehydrogenase/pyridine nucleotide transhydrogenase, NAD(H)-binding domain, IPR007886:Alanine dehydrogenase/pyridine nucleotide transhydrogenase, N-terminal, IPR016040:NAD(P)-binding domain, IPR032095:Saccharopine dehydrogenase, C-terminal" CG7144 27-Aug-18 DroID_v2018_08 Drer\aass "Scer\LYS9, Scer\LYS1" Cele\R02D3.1 Xtro\aass Mmus\Aass Hsap\AASS pupal stage salivary gland

"viable,fertile" wing FBgn0262385 mir-307a mir-307a stem loop http://flybase.org/reports/FBgn0262385 miRNA_gene - - - "dme-mir-307a, miR-307, mir-307a, mir-307, CR42913, CR33611, miR-307a, dme-miR-307a" - CR42913 27-Aug-18 DroID_v2018_08 - - - - - - "visible,lethal" wing FBgn0003247 rh roughish http://flybase.org/reports/FBgn0003247 - gene - compound eye development ; GO:0048749 | inferred from mutant phenotype - rh - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,recessive" "eye disc,ommatidium,eye photoreceptor cell,eye" FBgn0267385 PyK Pyruvate kinase http://flybase.org/reports/FBgn0267385 protein_coding_gene "magnesium ion binding ; GO:0000287 | inferred from electronic annotation with InterPro:IPR001697, InterPro:IPR015793, InterPro:IPR015794 potassium ion binding ; GO:0030955 | inferred from electronic annotation with InterPro:IPR001697, InterPro:IPR015793, InterPro:IPR015794 pyruvate kinase activity ; GO:0004743 | inferred from mutant phenotype" somatic muscle development ; GO:0007525 | inferred from mutant phenotype glycolytic process ; GO:0006096 | inferred from sequence or structural similarity with SGD:S000000036 response to sucrose ; GO:0009744 | inferred from mutant phenotype regulation of glucose metabolic process ; GO:0010906 | inferred from mutant phenotype pyruvate metabolic process ; GO:0006090 | inferred from sequence or structural similarity with SGD:S000000036 myoblast fusion ; GO:0007520 | inferred from mutant phenotype P granule ; GO:0043186 | inferred from physical interaction with tud inferred from physical interaction with vas cytosol ; GO:0005829 | inferred from direct assay lipid particle ; GO:0005811 | inferred from direct assay "Pyk, PK, PyK, l(3)r[Q178], CG7070, PYK, l(3)rQ178, Pk" "IPR018209:Pyruvate kinase, active site, IPR015813:Pyruvate/Phosphoenolpyruvate kinase-like domain, IPR001697:Pyruvate kinase, IPR011037:Pyruvate kinase-like, insert domain, IPR015793:Pyruvate kinase, barrel, IPR015795:Pyruvate kinase, C-terminal" CG7070 27-Aug-18 DroID_v2018_08 "Drer\pklr, Drer\pkma, Drer\pkmb" "Scer\CDC19, Scer\PYK2" "Cele\pyk-2, Cele\pyk-1" "Xtro\pklr, Xtro\pkm" "Mmus\Pklr, Mmus\Pkm" "Hsap\PKM, Hsap\PKLR" FBgn0000241 bw brown http://flybase.org/reports/FBgn0000241 - protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR003439, InterPro:IPR017871 cholesterol transporter activity ; GO:0017127 | inferred from biological aspect of ancestor with PANTHER:PTN001059382 sterol-transporting ATPase activity ; GO:0034041 | inferred from biological aspect of ancestor with PANTHER:PTN001059382 synaptic vesicle amine transmembrane transporter activity ; GO:0005430 | inferred from mutant phenotype" ommochrome biosynthetic process ; GO:0006727 | inferred from mutant phenotype aminergic neurotransmitter loading into synaptic vesicle ; GO:0015842 | inferred from mutant phenotype sensory perception of sound ; GO:0007605 | inferred from mutant phenotype eye pigment precursor transport ; GO:0006856 | traceable author statement integral component of membrane ; GO:0016021 | inferred from biological aspect of ancestor with PANTHER:PTN000443108 plasma membrane ; GO:0005886 | inferred from biological aspect of ancestor with PANTHER:PTN000443108 "bw, CG17632, Pm, Su(w[coJ]), ptm, Su(w[co2])" "IPR003439:ABC transporter-like, IPR003593:AAA+ ATPase domain, IPR013525:ABC-2 type transporter, IPR005284:Pigment precursor permease, IPR017871:ABC transporter, conserved site, IPR027417:P-loop containing nucleoside triphosphate hydrolase" CG17632 27-Aug-18 DroID_v2018_08 "Drer\abcg8, Drer\abcg2a, Drer\abcg4b, Drer\abcg4a, Drer\abcg1, Drer\abcg2b, Drer\abcg5" "Scer\ADP1, Scer\PDR18, Scer\YOL075C, Scer\PDR10, Scer\SNQ2, Scer\PDR15, Scer\PDR5" "Cele\wht-6, Cele\abch-1, Cele\wht-2, Cele\wht-3, Cele\wht-8" "Xtro\abcg5, Xtro\abcg8" "Mmus\Abcg8, Mmus\Abcg4, Mmus\Abcg2, Mmus\Abcg1, Mmus\Abcg3, Mmus\Abcg5" "Hsap\ABCG4, Hsap\ABCG8, Hsap\ABCG1, Hsap\ABCG5" "eye color defective,dominant,chemical resistant,male,auditory perception defective,visible,viable,recessive,wild-type,lethal,fertile,enhancer of variegation" "pigment cell,pigment granule,hemolymph,ocellus,wing,eye" FBgn0267244 lncRNA:CR45684 - http://flybase.org/reports/FBgn0267244 non_protein_coding_gene - - - CR45684 - CR45684 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0052102 CG32102 - http://flybase.org/reports/FBgn0052102 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "BcDNA:RE42781, CG32102" - CG32102 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0003236 reti reticent http://flybase.org/reports/FBgn0003236 - gene - - - "ret, reti" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of embryonic stage,maternal effect,recessive,some die during embryonic stage" FBgn0001876 l(1)XN82b lethal (1) XN82b http://flybase.org/reports/FBgn0001876 - gene - - - l(1)XN82b - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0045850 l(4)102Fc lethal (4) 102Fc http://flybase.org/reports/FBgn0045850 gene - - - l(4)102Fc - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0031959 spz3 spatzle 3 http://flybase.org/reports/FBgn0031959 protein_coding_gene Toll binding ; GO:0005121 | inferred from sequence or structural similarity with spz Toll signaling pathway ; GO:0008063 | inferred from sequence or structural similarity with spz extracellular region ; GO:0005576 | inferred from sequence or structural similarity with spz "CG14533, CG7104, spz3, Spz3, CT21967, CT34263" "IPR015943:WD40/YVTN repeat-like-containing domain, IPR029034:Cystine-knot cytokine, IPR032104:Spaetzle" CG7104 27-Aug-18 DroID_v2018_08 - Scer\MRPS17 - - - Hsap\AUH "viable,fertile,lethal - all die before end of pupal stage,some die during pupal stage" FBgn0011446 l(3)neo2 lethal (3) neo2 http://flybase.org/reports/FBgn0011446 - gene - - - l(3)neo2 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0062701 EP1095 EP1095 http://flybase.org/reports/FBgn0062701 gene - - - "EP(2)1095, EP1095" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0262997 CR43305 - http://flybase.org/reports/FBgn0262997 non_protein_coding_gene - - - CR43305 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0011610 l(1)I33e14 lethal (1) I33e14 http://flybase.org/reports/FBgn0011610 FBgn0010206 gene - - - "l(1)33e14, l(1)I33e14" - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0259597 B0633 - http://flybase.org/reports/FBgn0259597 gene - - - B0633 - - 27-Aug-18 DroID_v2018_08 - - - - - - visible wing FBgn0262883 lncRNA:CR43238 - http://flybase.org/reports/FBgn0262883 non_protein_coding_gene - - - "CR43238, chr3R:26,572,448-26,572,516" - CR43238 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0001120 gnu giant nuclei http://flybase.org/reports/FBgn0001120 FBgn0036453 protein_coding_gene molecular_function ; GO:0003674 | no biological data available regulation of cell cycle ; GO:0051726 | inferred from mutant phenotype mitotic nuclear division ; GO:0007067 | inferred from mutant phenotype negative regulation of DNA replication ; GO:0008156 | inferred from mutant phenotype egg activation ; GO:0007343 | inferred from mutant phenotype regulation of cell cycle ; GO:0051726 | traceable author statement mitotic nuclear division ; GO:0007067 | traceable author statement inferred from genetic interaction with CycB regulation of mitotic cell cycle ; GO:0007346 | traceable author statement - "CG5272, Gnu, gnu" "IPR001660:Sterile alpha motif domain, IPR013761:Sterile alpha motif/pointed domain" CG5272 27-Aug-18 DroID_v2018_08 - - - - - - " adult stage && O | stage S>=11 , embryonic stage | 0-1 hr " " oocyte

, organism

" "lethal,maternal effect,recessive,mitotic cell cycle defective,meiotic cell cycle defective,viable" "cleavage nucleus,maternal effect,female pronucleus | maternal effect,polar body nucleus,female,mitotic cell cycle | cleavage stage | maternal effect,cleavage stage embryo,nurse cell & nucleusmat.ë±Tub67C.THsimVP16,ovary,actin filament & nurse cellmat.ë±Tub67C.THsimVP16" FBgn0011671 musculin musculin http://flybase.org/reports/FBgn0011671 - gene - - - musculin - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0259475 C464 - http://flybase.org/reports/FBgn0259475 gene - - - C464 - - 27-Aug-18 DroID_v2018_08 - - - - - - visible wing hair FBgn0022974 snRNP120K snRNP120K http://flybase.org/reports/FBgn0022974 - gene - - - "120K, snRNP120K" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0050115 GEFmeso Guanine nucleotide exchange factor in mesoderm http://flybase.org/reports/FBgn0050115 protein_coding_gene Rho guanyl-nucleotide exchange factor activity ; GO:0005089 | inferred from physical interaction with Cdc42 Ral GTPase binding ; GO:0017160 | inferred from direct assay imaginal disc-derived leg morphogenesis ; GO:0007480 | inferred from mutant phenotype regulation of Cdc42 protein signal transduction ; GO:0032489 | inferred from physical interaction with Cdc42 imaginal disc-derived wing vein specification ; GO:0007474 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available "CG5503, CG18430, CG30115, GEFmeso" "IPR000219:Dbl homology (DH) domain, IPR001849:Pleckstrin homology domain, IPR011993:PH domain-like" CG30115 27-Aug-18 DroID_v2018_08 "Drer\mcf2l2, Drer\plekhg2, Drer\vav3b, Drer\spata13, Drer\arhgef4, Drer\arhgef9b, Drer\arhgef9a, Drer\LOC101885278, Drer\pex13, Drer\prex1, Drer\vav2, Drer\plekhg3" "Scer\PEX13, Scer\CDC24" "Cele\prx-13, Cele\vav-1, Cele\uig-1, Cele\tiam-1, Cele\Y37A1B.17" "Xtro\plekhg3, Xtro\plekhg1" "Mmus\Plekhg1, Mmus\Plekhg3, Mmus\Prex1, Mmus\Arhgef4, Mmus\Arhgef9, Mmus\Vav3, Mmus\Vav2, Mmus\Plekhg2, Mmus\Vav1, Mmus\Pex13, Mmus\Spata13" "Hsap\VAV2, Hsap\SPATA13, Hsap\PREX1, Hsap\PEX13, Hsap\PLEKHG2, Hsap\PLEKHG3, Hsap\VAV1, Hsap\PLEKHG1, Hsap\ARHGEF9, Hsap\ARHGEF4, Hsap\VAV3" "lethal - all die before end of larval stage,some die during larval stage,lethal - all die before end of pupal stage,some die during pupal stage,partially lethal - majority die" "crossvein,mesoderm,supernumerary" FBgn0264460 asRNA:CR43868 - http://flybase.org/reports/FBgn0264460 non_protein_coding_gene - - - CR43868 - CR43868 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0265544 CR44394 - http://flybase.org/reports/FBgn0265544 pseudogene_attribute - - - CR44394 - CR44394 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0051215 tRNA:Ala-AGC-2-11 transfer RNA:Alanine-AGC 2-11 http://flybase.org/reports/FBgn0051215 tRNA_gene GCU codon-amino acid adaptor activity ; GO:0033453 | inferred from sequence model translation ; GO:0006412 | inferred by curator from GO:0033453 cytosol ; GO:0005829 | inferred by curator from GO:0033453 "AE002708.trna21-AlaAGC, tRNA:A:AGC:AE002708-f, CR31215, tRNA[[Ala]], chr3R.trna27-AlaAGC, tRNA-Ala-AGC-2-11, tRNA:Ala-AGC-2-11, tRNA:CR31215, GCU" - CR31215 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0026194 pana pollyanna http://flybase.org/reports/FBgn0026194 - gene molecular_function ; GO:0003674 | no biological data available - cellular_component ; GO:0005575 | no biological data available "fret, pana" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0260091 2L2676 - http://flybase.org/reports/FBgn0260091 gene - - - 2L2676 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" "embryonic/larval dorsal trunk,somatic clone" FBgn0051148 Gba1a Glucocerebrosidase 1a http://flybase.org/reports/FBgn0051148 protein_coding_gene glucosylceramidase activity ; GO:0004348 | inferred from genetic interaction with Gba1b glucosylceramide catabolic process ; GO:0006680 | inferred from biological aspect of ancestor with PANTHER:PTN001667738 adult locomotory behavior ; GO:0008344 | inferred from genetic interaction with Gba1b memory ; GO:0007613 | inferred from genetic interaction with Gba1b neuron cellular homeostasis ; GO:0070050 | inferred from genetic interaction with Gba1b determination of adult lifespan ; GO:0008340 | inferred from genetic interaction with Gba1b cellular response to unfolded protein ; GO:0034620 | inferred from genetic interaction with Gba1b lysosome ; GO:0005764 | inferred from biological aspect of ancestor with PANTHER:PTN000869635 "CG10299, CT28913, anon-WO0140519.234, CG31148, dGBA1a, Gba1a" "IPR001139:Glycoside hydrolase family 30, IPR017853:Glycoside hydrolase superfamily, IPR033452:Glycosyl hydrolase family 30, beta sandwich domain, IPR033453:Glycosyl hydrolase family 30, TIM-barrel domain" CG31148 27-Aug-18 DroID_v2018_08 Drer\gba - "Cele\gba-3, Cele\gba-1, Cele\gba-2, Cele\gba-4" - Mmus\Gba Hsap\GBA "viable,visible" mesothoracic tergum FBgn0002116 l(2)cg lethal (2) with comb gap http://flybase.org/reports/FBgn0002116 - gene - - - l(2)cg - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0029167 Hml Hemolectin http://flybase.org/reports/FBgn0029167 protein_coding_gene chitin binding ; GO:0008061 | inferred from electronic annotation with InterPro:IPR002557 protein homodimerization activity ; GO:0042803 | inferred from direct assay chitin metabolic process ; GO:0006030 | inferred from electronic annotation with InterPro:IPR002557 hemostasis ; GO:0007599 | inferred from expression pattern melanization defense response ; GO:0035006 | NOT inferred from mutant phenotype hemolymph coagulation ; GO:0042381 | inferred from mutant phenotype wound healing ; GO:0042060 | inferred from mutant phenotype hemostasis ; GO:0007599 | inferred from mutant phenotype extracellular region ; GO:0005576 | inferred from direct assay "Hml, hml, CG7002, d-hml, CT21553" "IPR000421:Coagulation factor 5/8 C-terminal domain, IPR000742:EGF-like domain, IPR001007:VWFC domain, IPR001846:von Willebrand factor, type D domain, IPR002557:Chitin binding domain, IPR002919:Trypsin Inhibitor-like, cysteine rich domain, IPR006207:Cystine knot, C-terminal, IPR012111:Hemolectin/hemocytin, IPR013032:EGF-like, conserved site, IPR014853:Uncharacterised domain, cysteine-rich, IPR008979:Galactose-binding domain-like, IPR002172:Low-density lipoprotein (LDL) receptor class A repeat" CG7002 27-Aug-18 DroID_v2018_08 "Drer\LOC100147849, Drer\asic2, Drer\otogl, Drer\muc2.1, Drer\si:ch211-39f2.3, Drer\tecta, Drer\LOC100329651, Drer\fras1, Drer\muc5f, Drer\scospondin, Drer\LOC101887000, Drer\vwf, Drer\si:dkey-65b12.6, Drer\si:dkey-239b22.1, Drer\LOC799643, Drer\muc5.2, Drer\LOC100147904, Drer\muc5.1, Drer\otog, Drer\ch1073-291c23.1, Drer\si:dkey-266m15.6, Drer\wu:fb63a08" "Scer\HPF1, Scer\HKR1, Scer\FLO9, Scer\YIL169C, Scer\MSB2, Scer\FLO1, Scer\FIG2, Scer\PRM7, Scer\YMR317W, Scer\FLO5, Scer\FLO11" "Cele\dpy-6, Cele\C18H7.1, Cele\H43E16.1, Cele\ZC178.2, Cele\clec-223, Cele\F36H9.4, Cele\C53B7.2, Cele\T01D3.6, Cele\C25E10.10, Cele\C10G8.4, Cele\H02F09.3, Cele\F53C11.9, Cele\srap-1" "Xtro\muc6, Xtro\tecta.1, Xtro\zan, Xtro\LOC100485197, Xtro\LOC100497909, Xtro\vwf, Xtro\otogl, Xtro\fras1, Xtro\kcp, Xtro\LOC100492852" "Mmus\Kcp, Mmus\Fcgbp, Mmus\Muc5ac, Mmus\Vwce, Mmus\Otogl, Mmus\Otog, Mmus\Fras1, Mmus\Muc5b, Mmus\Tecta, Mmus\Muc2, Mmus\Muc6, Mmus\9530053A07Rik, Mmus\Muc4, Mmus\Zan, Mmus\Sspo, Mmus\Vwf, Mmus\Muc19" "Hsap\FRAS1, Hsap\MUC16, Hsap\MUC6, Hsap\OTOG, Hsap\FCGBP, Hsap\MUC4, Hsap\MUC2, Hsap\MUC19, Hsap\MUC5B, Hsap\MUC5AC, Hsap\VWF, Hsap\TECTA, Hsap\VWCE, Hsap\ZAN, Hsap\OTOGL, Hsap\SSPO, Hsap\MUC17" " embryonic stage | stage 17 , larval stage | first instar , larval stage " " embryonic hemocyte

, larval hemocyte

, organism

, crystal cell | subset

, plasmatocyte | subset

" "viable,fertile,immune response defective" FBgn0028385 cod capodimonte http://flybase.org/reports/FBgn0028385 gene - - - cod - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0004068 fs(2)mel2 female sterile (2) maternal effect lethal 2 http://flybase.org/reports/FBgn0004068 - gene - - - "mel 2, fs(2)mel2" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of embryonic stage,maternal effect,recessive,some die during embryonic stage" "cephalopharyngeal skeleton,abdominal 1 ventral denticle belt,abdominal 2 ventral denticle belt,abdominal 3 ventral denticle belt,abdominal 4 ventral denticle belt,abdominal 5 ventral denticle belt,abdominal 6 ventral denticle belt,abdominal 7 ventral denticle belt,embryo,maternal effect" FBgn0267132 lncRNA:CR45572 - http://flybase.org/reports/FBgn0267132 non_protein_coding_gene - - - CR45572 - CR45572 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0040050 CG17403 - http://flybase.org/reports/FBgn0040050 protein_coding_gene - - - CG17403 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0065757 l(2)SH0486 lethal (2) SH0486 http://flybase.org/reports/FBgn0065757 gene - - - "l(2)SH0486, l(2)SH2 0486" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0275436 PheRS-m "Phenylalanyl-tRNA synthetase, mitochondrial" http://flybase.org/reports/FBgn0275436 protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR002319, InterPro:IPR004530, InterPro:IPR005121 phenylalanine-tRNA ligase activity ; GO:0004826 | inferred from biological aspect of ancestor with PANTHER:PTN000165932 phenylalanine-tRNA ligase activity ; GO:0004826 | traceable author statement tRNA binding ; GO:0000049 | inferred from sequence or structural similarity with UniProtKB:O95363 phenylalanine-tRNA ligase activity ; GO:0004826 | inferred from sequence or structural similarity with UniProtKB:O95363 phenylalanine-tRNA ligase activity ; GO:0004826 | inferred from sequence or structural similarity with UniProtKB:P08425" phenylalanyl-tRNA aminoacylation ; GO:0006432 | traceable author statement tRNA processing ; GO:0008033 | inferred from sequence or structural similarity with UniProtKB:O95363 phenylalanyl-tRNA aminoacylation ; GO:0006432 | inferred from biological aspect of ancestor with PANTHER:PTN000165932 phenylalanyl-tRNA aminoacylation ; GO:0006432 | inferred from sequence or structural similarity with UniProtKB:O95363 phenylalanyl-tRNA aminoacylation ; GO:0006432 | inferred from sequence or structural similarity with UniProtKB:P08425 mitochondrion ; GO:0005739 | inferred from biological aspect of ancestor with PANTHER:PTN000165999 mitochondrion ; GO:0005739 | inferred from sequence or structural similarity with UniProtKB:P08425 mitochondrion ; GO:0005739 | traceable author statement "mtPheRS, PheRS, FRS, Pts, CG13348, Aats-phe, PheRS-m, Aats-phe-m" "IPR002319:Phenylalanyl-tRNA synthetase, IPR004530:Phenylalanyl-tRNA synthetase, class IIc, mitochondrial, IPR005121:Ferrodoxin-fold anticodon-binding domain, IPR006195:Aminoacyl-tRNA synthetase, class II" CG13348 27-Aug-18 DroID_v2018_08 "Drer\si:dkey-71l1.3, Drer\fars2" Scer\MSF1 Cele\fars-2 "Xtro\alg9, Xtro\fars2" "Mmus\Fdxacb1, Mmus\Fars2" "Hsap\FARS2, Hsap\FDXACB1" "viable,visible,decreased cell size,cell autonomous,somatic clone" "trichogen cell,lysosome & larval fat body | somatic clone | cell autonomous" FBgn0032285 CG17108 - http://flybase.org/reports/FBgn0032285 protein_coding_gene - - - "CT33647, gh23489, BEST:GH23489, CG17108" - CG17108 27-Aug-18 DroID_v2018_08 - - - - - - "visible,partially lethal - majority die,some die during pupal stage" trichogen cell FBgn0038201 PK1-R Pyrokinin 1 receptor http://flybase.org/reports/FBgn0038201 protein_coding_gene G-protein coupled receptor activity ; GO:0004930 | inferred from sequence or structural similarity inferred from direct assay pyrokinin receptor activity ; GO:0036401 | inferred from physical interaction with Capa neuropeptide receptor activity ; GO:0008188 | inferred from sequence model G-protein coupled receptor signaling pathway ; GO:0007186 | inferred from sequence or structural similarity G-protein coupled receptor signaling pathway ; GO:0007186 | inferred from sequence model triglyceride homeostasis ; GO:0070328 | inferred from mutant phenotype negative regulation of peptide hormone secretion ; GO:0090278 | inferred from mutant phenotype neuropeptide signaling pathway ; GO:0007218 | inferred from direct assay integral component of membrane ; GO:0016021 | inferred from sequence or structural similarity integral component of plasma membrane ; GO:0005887 | inferred from direct assay integral component of plasma membrane ; GO:0005887 | inferred from sequence or structural similarity integral component of membrane ; GO:0016021 | inferred from sequence model "anon-WO0170980.113, anon-WO0170980.112, CG9918, PK1-R, Pk1r, Pk1R, pkr1" "IPR000276:G protein-coupled receptor, rhodopsin-like, IPR017452:GPCR, rhodopsin-like, 7TM" CG9918 27-Aug-18 DroID_v2018_08 "Drer\ghsrb, Drer\ntsr1, Drer\nmur3, Drer\LOC101885431, Drer\LOC101885494, Drer\LOC101885849, Drer\nmur1a, Drer\mlnr, Drer\nmur1b, Drer\ghsra, Drer\gpr39, Drer\LOC103910036" - "Cele\nmur-4, Cele\npr-32, Cele\nmur-1, Cele\nmur-2, Cele\nmur-3" Xtro\nmur2 "Mmus\Nmur2, Mmus\Gpr39, Mmus\Ghsr, Mmus\Ntsr2, Mmus\Nmur1, Mmus\Ntsr1" "Hsap\GHSR, Hsap\NTSR2, Hsap\GPR148, Hsap\NTSR1, Hsap\GPR39, Hsap\MLNR, Hsap\NMUR1, Hsap\NMUR2" "viable,fertile" FBgn0086417 l(3)CHa lethal (3) CHa http://flybase.org/reports/FBgn0086417 gene - - - l(3)CHa - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0004067 fs(2)mel1 female sterile (2) maternal effect lethal 1 http://flybase.org/reports/FBgn0004067 - gene - - - "mel 1, fs(2)mel1" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of embryonic stage,maternal effect,recessive,some die during embryonic stage" "egg,maternal effect,embryo" FBgn0259713 CG42367 - http://flybase.org/reports/FBgn0259713 protein_coding_gene structural constituent of cuticle ; GO:0042302 | inferred from electronic annotation with InterPro:IPR000618 biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG31878, CG42367, CG4588" "IPR000618:Insect cuticle protein, IPR031311:Chitin-binding type R&R consensus" CG42367 27-Aug-18 DroID_v2018_08 Drer\mak Scer\IME2 Cele\fbxb-38 "Xtro\mak, Xtro\ick" "Mmus\Mak, Mmus\Ick, Mmus\Mok" "Hsap\MOK, Hsap\ICK, Hsap\MAK" "viable,fertile" FBgn0050020 CG30020 - http://flybase.org/reports/FBgn0050020 protein_coding_gene zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR012934 DNA binding ; GO:0003677 | inferred from direct assay - nucleus ; GO:0005634 | inferred from electronic annotation with InterPro:IPR012934 "CG18353, CG12941, p190, BEST:LD40262, CG30020" "IPR012934:Zinc finger, AD-type, IPR013083:Zinc finger, RING/FYVE/PHD-type, IPR013087:Zinc finger C2H2-type" CG30020 27-Aug-18 DroID_v2018_08 - Scer\RME1 - Xtro\sall1 "Mmus\Zfp580, Mmus\Zfp524" "Hsap\ZNF581, Hsap\ZNF524, Hsap\ZNF580" "viable,fertile" DRSC06730 K 1.032061316 0.017303785 0.417735398 -0.024358721 -1.79978409 -0.412861659 FBgn0085591 CG41274 - http://flybase.org/reports/FBgn0085591 protein_coding_gene - - - CG41274 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0031452 Cwc25 Cwc25 http://flybase.org/reports/FBgn0031452 protein_coding_gene molecular_function ; GO:0003674 | no biological data available - cellular_component ; GO:0005575 | no biological data available "Cwc25, CG2843, CWC25" "IPR019339:CBF1-interacting co-repressor CIR, N-terminal domain, IPR022209:Pre-mRNA splicing factor" CG2843 27-Aug-18 DroID_v2018_08 Drer\cwc25 Scer\CWC25 Cele\mog-3 Xtro\cwc25 Mmus\Cwc25 Hsap\CWC25 "lethal - all die before end of pupal stage,some die during pupal stage" FBgn0266005 lncRNA:CR44779 - http://flybase.org/reports/FBgn0266005 non_protein_coding_gene - - - CR44779 - CR44779 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0083240 EP2204 EP2204 http://flybase.org/reports/FBgn0083240 gene - - - EP2204 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0021986 l(2)k09801 lethal (2) k09801 http://flybase.org/reports/FBgn0021986 - gene - - - "P918, l(2)k09801" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0041234 Gr59f Gustatory receptor 59f http://flybase.org/reports/FBgn0041234 protein_coding_gene taste receptor activity ; GO:0008527 | non-traceable author statement sensory perception of taste ; GO:0050909 | inferred from electronic annotation with InterPro:IPR013604 detection of chemical stimulus involved in sensory perception of taste ; GO:0050912 | non-traceable author statement integral component of membrane ; GO:0016021 | inferred from electronic annotation with InterPro:IPR013604 integral component of membrane ; GO:0016021 | non-traceable author statement "Gr59E1, CG5365, 59E.1, GR59E.1, CG33150, Gr59f" IPR013604:7TM chemoreceptor CG33150 27-Aug-18 DroID_v2018_08 "Drer\gstt2, Drer\gstt1b, Drer\gstr, Drer\mars, Drer\eef1g, Drer\vars, Drer\gstt1a, Drer\eef1e1" "Scer\CAM1, Scer\YGR201C, Scer\TEF4, Scer\GTT2, Scer\URE2, Scer\GTT1" - "Xtro\eef1e1, Xtro\eef1g, Xtro\gstt1" "Mmus\Gstt1, Mmus\Vars, Mmus\Gstt3, Mmus\Gstt4, Mmus\Gstt2, Mmus\Mars, Mmus\Eef1e1, Mmus\Eef1g" "Hsap\EEF1G, Hsap\GSTT2, Hsap\EEF1E1, Hsap\GSTT2B, Hsap\GSTT1, Hsap\MARS, Hsap\VARS" partially lethal - majority die FBgn0020581 anon-59Cd anon-59Cd http://flybase.org/reports/FBgn0020581 - gene - - - anon-59Cd - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0043026 l(2)42Fa lethal (2) 42Fa http://flybase.org/reports/FBgn0043026 gene - - - l(2)42Fa - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0266921 ft::Hsap\FAT4 - http://flybase.org/reports/FBgn0266921 engineered_fusion_gene - - - "ft::Hsap\FAT4, Fat:Fat4" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0031513 CG3347 - http://flybase.org/reports/FBgn0031513 protein_coding_gene zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR001965 - - CG3347 "IPR011011:Zinc finger, FYVE/PHD-type, IPR019787:Zinc finger, PHD-finger, IPR013083:Zinc finger, RING/FYVE/PHD-type, IPR001965:Zinc finger, PHD-type, IPR019786:Zinc finger, PHD-type, conserved site" CG3347 27-Aug-18 DroID_v2018_08 "Drer\bptf, Drer\cxxc1b, Drer\cxxc1a" "Scer\SPP1, Scer\CTI6" Cele\cfp-1 "Xtro\cxxc1, Xtro\bptf" "Mmus\Cxxc1, Mmus\Bptf, Mmus\Dido1" "Hsap\CXXC1, Hsap\DIDO1, Hsap\BPTF" viable DRSC00597 K 0.007647223 -0.538442014 -0.702709217 0.05744939 -0.050026463 1.621872587 FBgn0259171 Pde9 Phosphodiesterase 9 http://flybase.org/reports/FBgn0259171 protein_coding_gene "3',5'-cyclic-nucleotide phosphodiesterase activity ; GO:0004114 | inferred from electronic annotation with InterPro:IPR002073 3',5'-cyclic-nucleotide phosphodiesterase activity ; GO:0004114 | inferred from sequence model" signal transduction ; GO:0007165 | inferred from electronic annotation with InterPro:IPR002073 cyclic nucleotide metabolic process ; GO:0009187 | inferred from sequence model neurogenesis ; GO:0022008 | inferred from mutant phenotype - "CG42276, PDE9, CG32648, CG3765, CG3761, CG1627, Pde9, CG3754" "IPR002073:3'5'-cyclic nucleotide phosphodiesterase, catalytic domain, IPR003607:HD/PDEase domain, IPR023088:3'5'-cyclic nucleotide phosphodiesterase, IPR023174:3'5'-cyclic nucleotide phosphodiesterase, conserved site" CG42276 27-Aug-18 DroID_v2018_08 "Drer\LOC571737, Drer\pde4ba, Drer\pde11a, Drer\pde4bb, Drer\pde4a, Drer\pde5aa, Drer\pde6c, Drer\pde5ab, Drer\pde6b, Drer\pde10a, Drer\crtc1b, Drer\pde9a, Drer\pde6a, Drer\pde4ca, Drer\pde2a, Drer\pde4d, Drer\si:dkey-219c10.4, Drer\pde11al, Drer\pde9al, Drer\pde7a" Scer\PDE2 Cele\pde-6 "Xtro\pde7b, Xtro\pde6a, Xtro\pde4c, Xtro\pde2a, Xtro\pde5a, Xtro\pde7a, Xtro\pde4a, Xtro\LOC100493061, Xtro\pde6b, Xtro\pde9a, Xtro\pde10a, Xtro\pde11a, Xtro\pde4b, Xtro\pde4d, Xtro\pde6c" "Mmus\Pde10a, Mmus\Pde9a, Mmus\Pde2a, Mmus\Pde6b, Mmus\Pde8a, Mmus\Pde11a, Mmus\Pde4b, Mmus\Pde8b, Mmus\Pde4a, Mmus\Pde7b, Mmus\Pde5a, Mmus\Pde7a, Mmus\Pde6a, Mmus\Pde4d, Mmus\Pde6c, Mmus\Pde4c" "Hsap\PDE4D, Hsap\PDE10A, Hsap\PDE2A, Hsap\PDE8B, Hsap\PDE4C, Hsap\PDE7A, Hsap\PDE6B, Hsap\PDE6C, Hsap\PDE9A, Hsap\PDE4B, Hsap\PDE4A, Hsap\PDE5A, Hsap\PDE6A, Hsap\PDE11A, Hsap\PDE8A, Hsap\PDE7B" FBgn0038529 CG14323 - http://flybase.org/reports/FBgn0038529 protein_coding_gene - - - CG14323 - CG14323 27-Aug-18 DroID_v2018_08 - - - - - - viable DRSC14802 E -0.68520201 -0.081526843 1.966632417 0.21844102 -0.279816649 0.157506215 FBgn0050443 Opbp Optix-binding protein http://flybase.org/reports/FBgn0050443 protein_coding_gene nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR013087 - - "Obp, OBP, CG12397, BcDNA:RE37461, CG30443, Opbp" "IPR013087:Zinc finger C2H2-type, IPR013083:Zinc finger, RING/FYVE/PHD-type" CG30443 27-Aug-18 DroID_v2018_08 "Drer\LOC100001832, Drer\znf1161, Drer\znf143a, Drer\zgc:113295, Drer\zgc:113030, Drer\zgc:113377, Drer\LOC100537377, Drer\zgc:113343, Drer\LOC798256, Drer\zgc:153116, Drer\blf, Drer\LOC103908714, Drer\znf1157, Drer\si:dkey-1b17.8, Drer\LOC101885996, Drer\LOC100333228, Drer\si:rp71-1h20.5, Drer\LOC100534908, Drer\zgc:110249, Drer\si:ch73-367f21.6, Drer\si:ch211-202h22.10, Drer\LOC100535934, Drer\zgc:174288, Drer\si:ch211-155e24.3, Drer\si:ch211-161m3.4, Drer\zgc:163077, Drer\si:ch211-241e1.5, Drer\zgc:162936, Drer\zgc:113348, Drer\znf407, Drer\LOC101883936, Drer\si:dkey-226l10.6, Drer\LOC100535458, Drer\zgc:175107, Drer\klf1, Drer\zgc:171551, Drer\si:ch73-367f21.4, Drer\si:ch73-299h12.4, Drer\si:dkeyp-53d3.3, Drer\znf1178, Drer\LOC101886221, Drer\si:ch73-299h12.6, Drer\znf995, Drer\znf1154, Drer\LOC100537687, Drer\si:ch211-110e21.4, Drer\zgc:194336, Drer\LOC101884416, Drer\zgc:171220, Drer\si:dkey-210j14.3, Drer\znf971, Drer\LOC101884439, Drer\si:dkey-253d23.8, Drer\zgc:174263, Drer\si:dkeyp-68b7.7, Drer\LOC103910593, Drer\si:ch211-161m3.2, Drer\LOC100002469, Drer\znf143b, Drer\si:ch211-222k6.1, Drer\pogza, Drer\znf970, Drer\si:dkey-15h8.16, Drer\si:ch1073-127d16.1, Drer\zgc:113294, Drer\si:ch73-138e16.4" Scer\AZF1 "Cele\che-1, Cele\hinf-1, Cele\Y55F3AM.14, Cele\zfp-2, Cele\ces-1" "Xtro\znf143, Xtro\zxdc, Xtro\znf280d" "Mmus\Prdm9, Mmus\Zfp27, Mmus\Zfp280b, Mmus\Prdm4, Mmus\Zfp422, Mmus\Zfp26, Mmus\Zfp143, Mmus\Zfp808, Mmus\Zbtb24, Mmus\Pogz, Mmus\Zfp275, Mmus\Zfp280d, Mmus\Zfp280c, Mmus\Zfp523" "Hsap\ZNF808, Hsap\ZNF619, Hsap\ZNF583, Hsap\ZNF813, Hsap\POGZ, Hsap\ZNF280A, Hsap\ZNF765, Hsap\ZXDA, Hsap\ZNF280B, Hsap\ZNF280C, Hsap\ZNF418, Hsap\ZNF22, Hsap\ZNF76, Hsap\ZNF468, Hsap\ZNF280D, Hsap\ZNF17, Hsap\ZNF143, Hsap\ZXDB" "viable,fertile" FBgn0260375 GSd446 - http://flybase.org/reports/FBgn0260375 gene - - - GSd446 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,neuroanatomy defective" "ventral nerve cord,intersegmental nerve,segmental nerve" FBgn0285912 mah mahogany http://flybase.org/reports/FBgn0285912 protein_coding_gene amino acid transmembrane transporter activity ; GO:0015171 | inferred from sequence or structural similarity with Eaat1 amino acid transmembrane transport ; GO:0003333 | inferred from sequence or structural similarity with Eaat1 - "mah, CG13646" "IPR013057:Amino acid transporter, transmembrane domain" CG13646 27-Aug-18 DroID_v2018_08 "Drer\slc32a1, Drer\si:dkey-126h10.1" - "Cele\Y4C6B.2, Cele\R02F2.8, Cele\Y59H11AR.4, Cele\Y18D10A.23, Cele\F21D12.3, Cele\unc-47, Cele\Y32F6A.4" - Mmus\Slc32a1 Hsap\SLC32A1 viable FBgn0025135 su(RpII140[Z36])S12 su(RpII140[Z36])S12 http://flybase.org/reports/FBgn0025135 - gene - - - "Z36[S12], su(RpII140[Z36])S12" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0082999 snoRNA:Psi28S-1192c snoRNA:Psi28S-1192c http://flybase.org/reports/FBgn0082999 snoRNA_gene - - - "snoRNA:Psi28S-1192c, Psi28S-1192c, psi28S-1192c, CR34595" - CR34595 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0065639 l(2)SH0762 lethal (2) SH0762 http://flybase.org/reports/FBgn0065639 gene - - - "l(2)SH0762, l(2)SH2 0762" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0017482 T3dh Type III alcohol dehydrogenase http://flybase.org/reports/FBgn0017482 - protein_coding_gene metal ion binding ; GO:0046872 | inferred from electronic annotation with InterPro:IPR001670 hydroxyacid-oxoacid transhydrogenase activity ; GO:0047988 | inferred from sequence or structural similarity with UniProtKB:Q8IWW8 alcohol dehydrogenase (NAD) activity ; GO:0004022 | inferred from biological aspect of ancestor with PANTHER:PTN001691340 oxidation-reduction process ; GO:0055114 | inferred from electronic annotation with InterPro:IPR001670 molecular hydrogen transport ; GO:0015993 | inferred from sequence or structural similarity with UniProtKB:Q8IWW8 mitochondrion ; GO:0005739 | inferred from biological aspect of ancestor with PANTHER:PTN000161036 cytosol ; GO:0005829 | inferred from biological aspect of ancestor with PANTHER:PTN001691340 mitochondrion ; GO:0005739 | inferred from sequence or structural similarity with UniProtKB:Q8R0N6 "CG3425, T3dh" "IPR001670:Alcohol dehydrogenase, iron-type" CG3425 27-Aug-18 DroID_v2018_08 Drer\adhfe1 Scer\ADH4 Cele\Y38F1A.6 Xtro\adhfe1 Mmus\Adhfe1 Hsap\ADHFE1 "viable,fertile,visible" trichogen cell FBgn0001416 l(1)5CDa lethal (1) 5CDa http://flybase.org/reports/FBgn0001416 - gene - - - "ts155, l(1)ts155, l(1)E12, l(1)5CDa" - - 27-Aug-18 DroID_v2018_08 - - - - - - "sterile,recessive,heat sensitive,lethal - all die before end of pupal stage,some die during pupal stage,chemical sensitive" FBgn0031607 CG15440 - http://flybase.org/reports/FBgn0031607 protein_coding_gene nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR000504 - - "cg15440, CG15440, Secp43" "IPR000504:RNA recognition motif domain, IPR034510:SECp43, RNA recognition motif 2" CG15440 27-Aug-18 DroID_v2018_08 "Drer\hnrnpd, Drer\rbm34, Drer\nono, Drer\hnrnpc, Drer\hnrnpabb, Drer\zgc:55733, Drer\zcrb1, Drer\tia1l, Drer\raly, Drer\cirbpa, Drer\trnau1apa, Drer\eif4h, Drer\hnrnpaba, Drer\sfpq, Drer\eif4ba, Drer\tial1, Drer\srsf10a, Drer\dazl, Drer\tia1, Drer\ncoa5, Drer\hnrnpa1b, Drer\wu:fq32h04, Drer\hnrnpa3, Drer\trnau1apb" "Scer\NOP6, Scer\MRN1, Scer\NAB6, Scer\NOP12, Scer\CWC2, Scer\NAM8, Scer\MUD1, Scer\PUB1, Scer\NGR1" "Cele\tiar-1, Cele\T07F10.3" "Xtro\rbm34, Xtro\ralyl, Xtro\trnau1ap, Xtro\dazl, Xtro\tia1, Xtro\eif4b, Xtro\hnrnpd, Xtro\hnrnpa3, Xtro\cirbp, Xtro\eif4h, Xtro\hnrnpa2b1, Xtro\sfpq, Xtro\hnrnpdl, Xtro\hnrnpa1, Xtro\hnrnpc, Xtro\raly, Xtro\hnrnpab" "Mmus\Srsf10, Mmus\Srsf12, Mmus\Boll, Mmus\Eif4b, Mmus\Slirp, Mmus\Eif4h, Mmus\Hnrnpa1, Mmus\Hnrnpa2b1, Mmus\Hnrnpa3, Mmus\Hnrnpab, Mmus\Rbm31y, Mmus\Hnrnpc, Mmus\Rbm34, Mmus\Trnau1ap, Mmus\Gm21379, Mmus\Raly, Mmus\Tia1, Mmus\Sfpq, Mmus\Tial1, Mmus\Hnrnpd, Mmus\Tra2b, Mmus\Pspc1, Mmus\Dazl, Mmus\Cirbp, Mmus\Zcrb1" "Hsap\BOLL, Hsap\DAZ2, Hsap\HNRNPA2B1, Hsap\SFPQ, Hsap\SRSF10, Hsap\HNRNPA1L2, Hsap\EIF4B, Hsap\RALYL, Hsap\RBM3, Hsap\C6orf52, Hsap\TIAL1, Hsap\DAZL, Hsap\HNRNPC, Hsap\DAZ1, Hsap\HNRNPA1, Hsap\HNRNPAB, Hsap\RALY, Hsap\HNRNPD, Hsap\TIA1, Hsap\RBM34, Hsap\DAZ3, Hsap\SLIRP, Hsap\PSPC1, Hsap\HNRNPA3, Hsap\DAZ4, Hsap\CIRBP, Hsap\TRNAU1AP, Hsap\EIF4H, Hsap\HNRNPCL1" "partially lethal - majority die,body color defective" mesothoracic tergum FBgn0001084 fy fuzzy http://flybase.org/reports/FBgn0001084 - protein_coding_gene - establishment of imaginal disc-derived wing hair orientation ; GO:0001737 | traceable author statement establishment or maintenance of cell polarity ; GO:0007163 | inferred from mutant phenotype establishment of planar polarity ; GO:0001736 | traceable author statement - "CG13396, fy" IPR026069:Fuzzy protein CG13396 27-Aug-18 DroID_v2018_08 Drer\fuz - - Xtro\fuz Mmus\Fuz Hsap\FUZ embryonic stage -- adult stage organism

"wild-type,planar polarity defective,viable,visible,recessive" "wing hair,wing hair & 1st posterior cell,wing hair & 3rd posterior cell,wing & trichome,wing cell,macrochaeta,microchaeta & adult thorax,wing margin bristle,microchaeta & leg,bract,trichome,trichogen cell" DRSC03533 K -0.677267405 -0.128713273 -0.429033216 0.283398489 1.524777308 -0.528743578 FBgn0030228 BTBD9 BTB (POZ) domain containing 9 http://flybase.org/reports/FBgn0030228 protein_coding_gene "ubiquitin protein ligase binding ; GO:0031625 | inferred from biological aspect of ancestor with PANTHER:PTN000698504 protein binding, bridging ; GO:0030674 | inferred from sequence or structural similarity with PDB:3HVE" "adult locomotory behavior ; GO:0008344 | inferred from mutant phenotype regulation of synaptic transmission, dopaminergic ; GO:0032225 | inferred from mutant phenotype protein ubiquitination involved in ubiquitin-dependent protein catabolic process ; GO:0042787 | inferred from biological aspect of ancestor with PANTHER:PTN000698504 positive regulation of circadian sleep/wake cycle, sleep ; GO:0045938 | inferred from mutant phenotype regulation of proteolysis ; GO:0030162 | inferred from biological aspect of ancestor with PANTHER:PTN000698504 proteasome-mediated ubiquitin-dependent protein catabolic process ; GO:0043161 | inferred from biological aspect of ancestor with PANTHER:PTN000698504" cytoplasm ; GO:0005737 | inferred from direct assay Cul3-RING ubiquitin ligase complex ; GO:0031463 | inferred from sequence or structural similarity with PDB:3HVE SCF ubiquitin ligase complex ; GO:0019005 | inferred from biological aspect of ancestor with PANTHER:PTN000698504 "BTBD9, dBTBD9, CG1826" "IPR000210:BTB/POZ domain, IPR008979:Galactose-binding domain-like, IPR011705:BTB/Kelch-associated, IPR011333:SKP1/BTB/POZ domain, IPR034091:BTBD9, BACK-like domain, IPR000421:Coagulation factor 5/8 C-terminal domain" CG1826 27-Aug-18 DroID_v2018_08 Drer\btbd9 Scer\YIL001W Cele\hpo-9 "Xtro\klhl41, Xtro\btbd9" Mmus\Btbd9 "Hsap\BTBD9, Hsap\BTBD19" "viable,short lived,sleep defective,recessive,locomotor behavior defective" DRSC22371 K -0.44672001 0.1189548 -0.571569764 -0.267415836 -1.553329981 -0.269928017 FBgn0038057 CG12267 - http://flybase.org/reports/FBgn0038057 protein_coding_gene DNA binding ; GO:0003677 | inferred from electronic annotation with InterPro:IPR008806 RNA polymerase III activity ; GO:0001056 | contributes_to inferred from biological aspect of ancestor with PANTHER:PTN000310442 "transcription, DNA-templated ; GO:0006351 | inferred from electronic annotation with InterPro:IPR008806" DNA-directed RNA polymerase III complex ; GO:0005666 | inferred from biological aspect of ancestor with PANTHER:PTN000310442 CG12267 "IPR008806:RNA polymerase III Rpc82, C -terminal, IPR013197:RNA polymerase III subunit RPC82-related, helix-turn-helix, IPR011991:Winged helix-turn-helix DNA-binding domain" CG12267 27-Aug-18 DroID_v2018_08 Drer\polr3c Scer\RPC82 Cele\let-611 Xtro\polr3c Mmus\Polr3c Hsap\POLR3C "lethal - all die before end of pupal stage,some die during pupal stage" FBgn0264629 asthmatic asthmatic http://flybase.org/reports/FBgn0264629 gene - "trachea morphogenesis ; GO:0060439 | inferred from mutant phenotype terminal branching, open tracheal system ; GO:0007430 | inferred from mutant phenotype" - asthmatic - - 27-Aug-18 DroID_v2018_08 - - - - - - "eye,somatic clone,terminal tracheal cell,embryonic/larval tracheal system" FBgn0050287 CG30287 - http://flybase.org/reports/FBgn0050287 protein_coding_gene "serine-type endopeptidase activity ; GO:0004252 | inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114" "proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114" - "SP37, SPH37, CG10450, CG30287" "IPR001254:Serine proteases, trypsin domain, IPR001314:Peptidase S1A, chymotrypsin family, IPR009003:Peptidase S1, PA clan, IPR018114:Serine proteases, trypsin family, histidine active site, IPR033116:Serine proteases, trypsin family, serine active site" CG30287 27-Aug-18 DroID_v2018_08 "Drer\si:dkeyp-93a5.3, Drer\zgc:165423, Drer\gzmk, Drer\zgc:163079, Drer\si:ch211-165b19.9, Drer\ovch1, Drer\masp2, Drer\si:ch211-165b19.8, Drer\zgc:92313, Drer\gzma, Drer\gzm3, Drer\si:dkey-16l2.17, Drer\si:ch211-165b19.5, Drer\f9a, Drer\LOC558805, Drer\LOC100004427, Drer\cfd" - "Cele\try-1, Cele\try-3, Cele\svh-1, Cele\try-6" - "Mmus\Klk15, Mmus\Tmprss12, Mmus\Klk1b9, Mmus\Klk9, Mmus\Egfbp2, Mmus\Klk1b5" "Hsap\TMPRSS12, Hsap\KLK9, Hsap\MASP1, Hsap\KLK15" FBgn0029769 frma fra mauro http://flybase.org/reports/FBgn0029769 protein_coding_gene "metalloendopeptidase activity ; GO:0004222 | inferred from electronic annotation with InterPro:IPR000718, InterPro:IPR018497" "proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR000718, InterPro:IPR008753, InterPro:IPR018497 negative regulation of female receptivity, post-mating ; GO:0045434 | inferred from mutant phenotype" - "BEST:GH09377, CG3239, frma" "IPR000718:Peptidase M13, IPR018497:Peptidase M13, C-terminal domain, IPR024079:Metallopeptidase, catalytic domain, IPR008753:Peptidase M13, N-terminal domain" CG3239 27-Aug-18 DroID_v2018_08 "Drer\mmel1, Drer\phex, Drer\ece2b, Drer\ece1" - "Cele\nep-18, Cele\nep-16, Cele\nep-21, Cele\nep-7, Cele\nep-8, Cele\nep-24, Cele\nep-19, Cele\nep-13, Cele\nep-6, Cele\nep-20, Cele\nep-10, Cele\nep-12, Cele\nep-5, Cele\nep-26, Cele\nep-9, Cele\nep-23, Cele\nep-3, Cele\nep-17" "Xtro\ece2, Xtro\mmel1, Xtro\ecel1, Xtro\ece1" "Mmus\Ece1, Mmus\Ece2, Mmus\Mme, Mmus\Ecel1, Mmus\Kel, Mmus\Mmel1, Mmus\Phex" "Hsap\MME, Hsap\MMEL1, Hsap\ECE2, Hsap\PHEX, Hsap\KEL, Hsap\ECEL1, Hsap\ECE1" "mating behavior defective,female limited,female semi-fertile" FBgn0039726 eIF2Balpha eukaryotic translation initiation factor 2B subunit alpha http://flybase.org/reports/FBgn0039726 protein_coding_gene translation initiation factor activity ; GO:0003743 | inferred from sequence or structural similarity with SGD:S000001734 translation initiation factor activity ; GO:0003743 | inferred from sequence or structural similarity enzyme regulator activity ; GO:0030234 | inferred from genetic interaction with SGD:S000001734 translational initiation ; GO:0006413 | inferred from sequence or structural similarity with SGD:S000001734 lateral inhibition ; GO:0046331 | inferred from mutant phenotype translational initiation ; GO:0006413 | inferred from sequence or structural similarity cytoplasm ; GO:0005737 | inferred from biological aspect of ancestor with PANTHER:PTN000027918 eukaryotic translation initiation factor 2B complex ; GO:0005851 | inferred from sequence or structural similarity eukaryotic translation initiation factor 2B complex ; GO:0005851 | inferred from sequence or structural similarity with SGD:S000001734 cytosol ; GO:0005829 | inferred from sequence or structural similarity "CG7883, DeIF2Balpha, eIF2B-alpha, Eif2b, eIF2Balpha" IPR000649:Initiation factor 2B-related CG7883 27-Aug-18 DroID_v2018_08 Drer\eif2b1 Scer\GCN3 "Cele\F11A3.2, Cele\ZK1098.4" Xtro\eif2b1 Mmus\Eif2b1 Hsap\EIF2B1 "viable,visible" "chaeta,trichogen cell" FBgn0029863 CG3823 - http://flybase.org/reports/FBgn0029863 protein_coding_gene transporter activity ; GO:0005215 | inferred from electronic annotation with InterPro:IPR001071 transport ; GO:0006810 | inferred from electronic annotation with InterPro:IPR001071 intracellular ; GO:0005622 | inferred from electronic annotation with InterPro:IPR001071 CG3823 "IPR001071:Cellular retinaldehyde binding/alpha-tocopherol transport, IPR001251:CRAL-TRIO lipid binding domain, IPR011074:CRAL/TRIO, N-terminal domain" CG3823 27-Aug-18 DroID_v2018_08 "Drer\clvs2, Drer\sec14l8, Drer\ttpa, Drer\rlbp1b, Drer\sec14l7, Drer\rlbp1a, Drer\ttpal" "Scer\YKL091C, Scer\SFH5, Scer\SEC14" - "Xtro\sec14l1, Xtro\clvs2, Xtro\mospd2, Xtro\sec14l3, Xtro\sec14l5, Xtro\clvs1, Xtro\ttpal, Xtro\ttpa, Xtro\rlbp1" "Mmus\Sec14l3, Mmus\Sec14l5, Mmus\Sec14l1, Mmus\Sec14l2, Mmus\Clvs2, Mmus\Sec14l4, Mmus\Ttpa, Mmus\Rlbp1, Mmus\Clvs1, Mmus\Ttpal" "Hsap\CLVS2, Hsap\SEC14L6, Hsap\SEC14L2, Hsap\SEC14L4, Hsap\CLVS1, Hsap\TTPAL, Hsap\SEC14L5, Hsap\SEC14L1, Hsap\RLBP1, Hsap\SEC14L3, Hsap\TTPA" "viable,fertile" FBgn0022745 anon-J1b anon-J1b http://flybase.org/reports/FBgn0022745 - gene - - - "J1, anon-J1b" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0040004 CG12552 - http://flybase.org/reports/FBgn0040004 protein_coding_gene - - - CG12552 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0263995 cpo couch potato http://flybase.org/reports/FBgn0263995 protein_coding_gene nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR000504 mRNA binding ; GO:0003729 | inferred from sequence or structural similarity dormancy process ; GO:0022611 | inferred from mutant phenotype detection of temperature stimulus involved in sensory perception of pain ; GO:0050965 | inferred from mutant phenotype regulation of hemocyte proliferation ; GO:0035206 | inferred from mutant phenotype chemical synaptic transmission ; GO:0007268 | inferred from mutant phenotype olfactory behavior ; GO:0042048 | inferred from mutant phenotype nucleus ; GO:0005634 | inferred from direct assay "cpo, CPO, CG43738, CG31243, ORE-17, CG12349, CG18435, cg18435, Cpo, l(3)6015, 6015, 5339, 3603, 1824, l(3)s2336, l(3)rJ553, l(3)j9B3, l(3)j7E2, l(3)j4D4, l(3)j4A1, l(3)01432, E(sda)N, CG18434, BcDNA:AT31405, Line N, CG42457" IPR000504:RNA recognition motif domain CG43738 27-Aug-18 DroID_v2018_08 "Drer\rbpms2a, Drer\LOC100537153, Drer\rbpms2b" "Scer\WHI3, Scer\WHI4, Scer\YGR250C" "Cele\mec-8, Cele\rsp-2" Xtro\rbpms "Mmus\Rbpms2, Mmus\Rbpms" "Hsap\RBPMS2, Hsap\RBPMS" embryonic stage " neuron &&of chordotonal organ

, embryonic peripheral nervous system

" embryonic stage " central nervous system

{ 0 AS-C- } , peripheral nervous system

, glial cell

, neuron chordotonal organ

{ 0 AS-C- } , sensory organ mother cell

{ - da* } , posterior spiracle

{ - AS-C- } , central nervous system

{ $ da* } , peripheral nervous system

{ 0 AS-C- } , peripheral nervous system

{ 0 da* } , embryonic central nervous system

, neuron

, embryonic/larval midgut

, midgut

{ 0 da* } , glial cell

{ 0 AS-C- } , midgut

" DRSC13265 I 1.374389261 1.553335766 -0.049318037 -0.250038696 -0.012647936 -0.182963195 FBgn0263960 BG01677 - http://flybase.org/reports/FBgn0263960 gene - - - BG01677 - - 27-Aug-18 DroID_v2018_08 - - - - - - "long lived,starvation stress response defective,male limited" FBgn0036812 Nufip Nufip http://flybase.org/reports/FBgn0036812 protein_coding_gene snoRNA binding ; GO:0030515 | inferred from biological aspect of ancestor with PANTHER:PTN000329871 box C/D snoRNP assembly ; GO:0000492 | inferred from biological aspect of ancestor with PANTHER:PTN000329871 nucleus ; GO:0005634 | inferred from biological aspect of ancestor with PANTHER:PTN000329871 "CG4076, NUFIP, Nufip" "IPR019496:Nuclear fragile X mental retardation-interacting protein 1, conserved domain" CG4076 27-Aug-18 DroID_v2018_08 Drer\nufip1 - - Xtro\nufip1 Mmus\Nufip1 Hsap\NUFIP1 "viable,visible,lethal - all die before end of pupal stage" trichogen cell FBgn0052431 CG32431 - http://flybase.org/reports/FBgn0052431 protein_coding_gene - - - CG32431 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0000796 fs(1)de7 female sterile (1) defective eggs 7 http://flybase.org/reports/FBgn0000796 - gene - - - "de7, fs(1)de7" - - 27-Aug-18 DroID_v2018_08 - - - - - - female sterile "dorsal appendage,chorion" FBgn0004505 fs(1)A5 female sterile (1) A5 http://flybase.org/reports/FBgn0004505 - gene - - - fs(1)A5 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0015454 l(2)24CDa lethal (2) 24CDa http://flybase.org/reports/FBgn0015454 - gene - - - "l(2)d, l(2)24CDa" - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0039169 Spps Sp1-like factor for pairing sensitive-silencing http://flybase.org/reports/FBgn0039169 protein_coding_gene "RNA polymerase II transcription factor activity, sequence-specific DNA binding ; GO:0000981 | inferred from biological aspect of ancestor with PANTHER:PTN001145452 sequence-specific DNA binding ; GO:0043565 | inferred from direct assay" regulation of gene silencing ; GO:0060968 | inferred from mutant phenotype regulation of transcription from RNA polymerase II promoter ; GO:0006357 | inferred from biological aspect of ancestor with PANTHER:PTN001145452 nucleus ; GO:0005634 | inferred from direct assay nucleus ; GO:0005634 | inferred from biological aspect of ancestor with PANTHER:PTN001145452 polytene chromosome band ; GO:0005704 | inferred from direct assay "CG5669, Spps" "IPR013087:Zinc finger C2H2-type, IPR013083:Zinc finger, RING/FYVE/PHD-type, IPR032675:Leucine-rich repeat domain, L domain-like" CG5669 27-Aug-18 DroID_v2018_08 "Drer\sp3b, Drer\sp5a, Drer\klf11b, Drer\sp1, Drer\sp8a, Drer\klf5a, Drer\sp9, Drer\zeb1a, Drer\klf5l, Drer\zgc:153115, Drer\sp7, Drer\zgc:77358, Drer\sp8b, Drer\sp4, Drer\sp3a, Drer\sp5l, Drer\sp5b, Drer\sp2, Drer\klf13" "Scer\CRZ1, Scer\SWI5, Scer\ACE2" "Cele\ZK686.5, Cele\sptf-1, Cele\sptf-3, Cele\klf-2, Cele\sptf-2" "Xtro\sp3, Xtro\sp7, Xtro\sp5, Xtro\sp6, Xtro\sp1, Xtro\sp2, Xtro\sp5l, Xtro\sp4" "Mmus\Sp7, Mmus\Sp9, Mmus\Sp6, Mmus\Sp8, Mmus\Sp5, Mmus\Sp1, Mmus\Sp3, Mmus\Klf5, Mmus\Klf13, Mmus\Klf10, Mmus\Sp4, Mmus\Sp2" "Hsap\SP9, Hsap\SP4, Hsap\SP2, Hsap\SP5, Hsap\SP8, Hsap\KLF10, Hsap\SP3, Hsap\SP7, Hsap\SP6, Hsap\SP1, Hsap\KLF13" "lethal,recessive,germline clone,penetrance incomplete (obsolete FBcv0000019),partially lethal - majority die,lethal - all die before end of P-stage,some die during pharate adult stage,viable,visible" "wing,mesothoracic tergum" FBgn0003108 pallid pallid http://flybase.org/reports/FBgn0003108 - gene - - - "pl, pallid, pld" - - 27-Aug-18 DroID_v2018_08 - - - - - - "partially lethal - majority live,body color defective" wing FBgn0036814 CG14073 - http://flybase.org/reports/FBgn0036814 protein_coding_gene molecular_function ; GO:0003674 | no biological data available "wing disc dorsal/ventral pattern formation ; GO:0048190 | inferred from genetic interaction with Bx, ap" - "Nirvana, CG14073" "IPR002110:Ankyrin repeat, IPR020683:Ankyrin repeat-containing domain" CG14073 27-Aug-18 DroID_v2018_08 "Drer\ankrd31, Drer\cdkn2c, Drer\bcor, Drer\bcorl1" "Scer\HOS4, Scer\YAR1" "Cele\frm-9, Cele\K02B12.5" "Xtro\bcor, Xtro\bcorl1" "Mmus\Cdkn2c, Mmus\Cdkn2d, Mmus\Bcorl1, Mmus\Bcor" "Hsap\BCORL1, Hsap\CDKN2D, Hsap\CDKN2C, Hsap\BCOR" viable FBgn0002463 l(3)SG16 lethal (3) SG16 http://flybase.org/reports/FBgn0002463 - gene - - - l(3)SG16 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0032817 CG10631 - http://flybase.org/reports/FBgn0032817 protein_coding_gene nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR006612 - - CG10631 "IPR006612:Zinc finger, C2CH-type, IPR013087:Zinc finger C2H2-type" CG10631 27-Aug-18 DroID_v2018_08 "Drer\znf574, Drer\znf710a, Drer\znf366, Drer\znf710b" - "Cele\ztf-29, Cele\zag-1" - "Mmus\Zfp366, Mmus\Zfp710" "Hsap\ZNF710, Hsap\ZNF366" viable FBgn0019740 l(1)91-1 lethal (1) 91-1 http://flybase.org/reports/FBgn0019740 - gene - - - l(1)91-1 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0259302 EP-108 - http://flybase.org/reports/FBgn0259302 gene - - - EP-108 - - 27-Aug-18 DroID_v2018_08 - - - - - - visible "wing vein,wing margin,chaeta" FBgn0044079 E(rst)H65 E(rst)H65 http://flybase.org/reports/FBgn0044079 gene molecular_function ; GO:0003674 | no biological data available compound eye morphogenesis ; GO:0001745 | inferred from genetic interaction with rst cellular_component ; GO:0005575 | no biological data available "H65, E(rst)H65" - - 27-Aug-18 DroID_v2018_08 - - - - - - viable eye FBgn0267030 lncRNA:CR45474 - http://flybase.org/reports/FBgn0267030 non_protein_coding_gene - - - CR45474 - CR45474 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0010243 Mst77F-PsiY1 Mst77F pseudogene on Y 1 http://flybase.org/reports/FBgn0010243 - pseudogene_attribute - - - "18c, Mst77F-PsiY1, Mst77-Psi1" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0030190 CG2908 - http://flybase.org/reports/FBgn0030190 protein_coding_gene - - - CG2908 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0263851 snoRNA:CD-24 - http://flybase.org/reports/FBgn0263851 snoRNA_gene - - - "snoRNA:CD-24, snoCD_24, CR43712" - CR43712 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0042697 N-fa-swb-INS Notch facet strawberry insulator element http://flybase.org/reports/FBgn0042697 insulator - - - "Fa[swb], fa[swb], N-fa-swb-INS" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0005465 l(1)ts88 lethal (1) ts88 http://flybase.org/reports/FBgn0005465 - gene - - - l(1)ts88 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,heat sensitive,female sterile" FBgn0039806 CG15545 - http://flybase.org/reports/FBgn0039806 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG15545 - CG15545 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0051488 CG31488 - http://flybase.org/reports/FBgn0051488 protein_coding_gene - - - CG31488 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0040806 CG13456 - http://flybase.org/reports/FBgn0040806 protein_coding_gene - - - CG13456 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0265077 lncRNA:CR44188 - http://flybase.org/reports/FBgn0265077 non_protein_coding_gene - - - CR44188 - CR44188 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0262653 l(3)ED220-1 - http://flybase.org/reports/FBgn0262653 gene - - - l(3)ED220-1 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of P-stage,recessive,some die during P-stage,lethal" FBgn0031985 mon2 monensin sensitivity 2 http://flybase.org/reports/FBgn0031985 protein_coding_gene cytoskeletal regulatory protein binding ; GO:0005519 | inferred from physical interaction with spir pole plasm protein localization ; GO:0007318 | inferred from mutant phenotype actin cytoskeleton reorganization ; GO:0031532 | inferred from mutant phenotype endosome ; GO:0005768 | inferred from direct assay Golgi apparatus ; GO:0005794 | inferred from direct assay "CG31756, CG14276, CG8683, mon2, noan, Mon2" "IPR015403:Sec7, C-terminal, IPR032817:Mon2, C-terminal, IPR032691:Guanine nucleotide exchange factor, N-terminal, IPR011989:Armadillo-like helical, IPR016024:Armadillo-type fold, IPR032629:Mon2, dimerisation and cyclophilin-binding domain" CG8683 27-Aug-18 DroID_v2018_08 Drer\mon2 Scer\MON2 Cele\mon-2 Xtro\mon2 Mmus\Mon2 Hsap\MON2 "viable,body color defective" mesothoracic tergum FBgn0016887 l(2)39DEl lethal (2) 39DEl http://flybase.org/reports/FBgn0016887 - gene - - - "K234, l(2)39DEl" - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0061516 cri criss-cross http://flybase.org/reports/FBgn0061516 gene molecular_function ; GO:0003674 | no biological data available embryonic development via the syncytial blastoderm ; GO:0001700 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available cri - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of embryonic stage,recessive,some die during embryonic stage" "embryonic head,embryonic abdominal segment 4,embryonic abdominal segment 5,embryonic abdominal segment 6,embryonic abdominal segment 7,embryonic abdominal segment 8,embryonic epidermis,denticle belt" FBgn0032077 CG9515 - http://flybase.org/reports/FBgn0032077 protein_coding_gene nucleoside-triphosphate diphosphatase activity ; GO:0047429 | inferred from electronic annotation with InterPro:IPR003697 - - "gh06087, CG33085, BEST:GH06087, CG9515" "IPR003697:Maf-like protein, IPR029001:Inosine triphosphate pyrophosphatase-like" CG9515 27-Aug-18 DroID_v2018_08 "Drer\asmt2, Drer\asmtl, Drer\asmt" Scer\YOR111W Cele\dod-18 "Xtro\asmt, Xtro\asmtl" Mmus\Asmt "Hsap\ASMT, Hsap\ASMTL" "viable,fertile" FBgn0004963 abg ambiguous http://flybase.org/reports/FBgn0004963 - gene molecular_function ; GO:0003674 | no biological data available cuticle pattern formation ; GO:0035017 | inferred from mutant phenotype oogenesis ; GO:0048477 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available abg - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of pupal stage,recessive,some die during pupal stage,lethal - all die before end of larval stage,some die during larval stage,lethal,rescuable maternal effect" "embryonic epidermis,germline clone,embryonic/first instar larval cuticle,ovary" FBgn0262024 CG42835 - http://flybase.org/reports/FBgn0262024 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG42835 - CG42835 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0020226 Calp14B Calpain 14B http://flybase.org/reports/FBgn0020226 - gene - - - Calp14B - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0031055 et eye transformer http://flybase.org/reports/FBgn0031055 protein_coding_gene cytokine receptor activity ; GO:0004896 | inferred from electronic annotation with InterPro:IPR003529 protein heterodimerization activity ; GO:0046982 | inferred from physical interaction with dome receptor activity ; GO:0004872 | inferred from sequence or structural similarity with dome defense response to bacterium ; GO:0042742 | inferred from mutant phenotype negative regulation of tyrosine phosphorylation of STAT protein ; GO:0042532 | inferred from mutant phenotype negative regulation of JAK-STAT cascade ; GO:0046426 | inferred from direct assay membrane ; GO:0016020 | inferred from electronic annotation with InterPro:IPR003529 "CG14225, et, ET, lat" "IPR003529:Long hematopoietin receptor, Gp130 family 2, conserved site, IPR003961:Fibronectin type III, IPR013783:Immunoglobulin-like fold" CG14225 27-Aug-18 DroID_v2018_08 - - - - - - "viable,fertile,stress response defective,RU486 conditional" "lamellocyte,wing,eye" FBgn0003679 te tenerchaetae http://flybase.org/reports/FBgn0003679 - gene - - - te - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,recessive,viable,good,male,male sterile,female sterile,eye color defective" "macrochaeta,wing,wing vein,pigment cell,eye" FBgn0086061 snoRNA:Or-CD8 - http://flybase.org/reports/FBgn0086061 snoRNA_gene - - - "snoRNA:Or-CD8, orphan CD8, DmOr_cd8, CR34690" - CR34690 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0250830 CG12547 - http://flybase.org/reports/FBgn0250830 protein_coding_gene - - - "CG40277, CG12547, anon-EST:Posey268" "IPR011042:Six-bladed beta-propeller, TolB-like, IPR012336:Thioredoxin-like fold, IPR013017:NHL repeat, subgroup, IPR001258:NHL repeat" CG12547 27-Aug-18 DroID_v2018_08 Drer\nhlrc2 - Cele\nhl-1 Xtro\nhlrc2 Mmus\Nhlrc2 Hsap\NHLRC2 FBgn0019921 T:nls-Sry-delta nuclear localisation signal of Sry-delta http://flybase.org/reports/FBgn0019921 - engineered_tag - - - "T:nls-Sry-delta, T:nls3" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0005315 mu-F mutator from Florida http://flybase.org/reports/FBgn0005315 - gene - - - mu-F - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0000276 CecA1 Cecropin A1 http://flybase.org/reports/FBgn0000276 - protein_coding_gene molecular_function ; GO:0003674 | no biological data available defense response to Gram-negative bacterium ; GO:0050829 | inferred from direct assay defense response to Gram-positive bacterium ; GO:0050830 | inferred from direct assay defense response to Gram-negative bacterium ; GO:0050829 | inferred from expression pattern defense response to bacterium ; GO:0042742 | traceable author statement autophagic cell death ; GO:0048102 | inferred from expression pattern salivary gland cell autophagic cell death ; GO:0035071 | inferred from expression pattern antibacterial humoral response ; GO:0019731 | inferred from expression pattern AND inferred from sequence or structural similarity antibacterial humoral response ; GO:0019731 | inferred from direct assay antibacterial humoral response ; GO:0019731 | inferred from expression pattern humoral immune response ; GO:0006959 | inferred from expression pattern response to bacterium ; GO:0009617 | inferred from expression pattern extracellular region ; GO:0005576 | inferred from direct assay extracellular space ; GO:0005615 | inferred from direct assay "CecA1, Cecropin A1, Cec, CEC, CecA, cec, CG1365, cecA1, cecA, Cec A1, crpA1, DIM 25, Cec-A1" "IPR000875:Cecropin, IPR020400:Cecropin, diptera" CG1365 27-Aug-18 DroID_v2018_08 - - - - - - " pupal stage , larval stage , adult stage " " embryonic/larval hemocyte

, adult fat body

" "viable,body color defective" "adult posterior midgut epithelium,mesothoracic tergum" FBgn0011105 l(1)Q66 lethal (1) Q66 http://flybase.org/reports/FBgn0011105 FBgn0010210 gene - - - l(1)Q66 - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0060548 l(3)S098516a lethal (3) S098516a http://flybase.org/reports/FBgn0060548 gene - - - "0985/16, l(3)S098516a" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0086449 Cog8 - http://flybase.org/reports/FBgn0086449 gene - - - Cog8 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0263555 mir-4943 mir-4943 stem loop http://flybase.org/reports/FBgn0263555 miRNA_gene - - - "mir-4943, dme-mir-4943, CR43540" - CR43540 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0040605 CG14236 - http://flybase.org/reports/FBgn0040605 protein_coding_gene - - - CG14236 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0000758 fs(1)A462 female sterile (1) A462 http://flybase.org/reports/FBgn0000758 - gene - - - "fs(1)462, fs(1)A462" - - 27-Aug-18 DroID_v2018_08 - - - - - - "female sterile soma-dependent,recessive" FBgn0011855 tRNA:Glu-CTC-3-9 transfer RNA:Glutamic acid-CTC 3-9 http://flybase.org/reports/FBgn0011855 "FBgn0003768, FBgn0003772, FBgn0011846, FBgn0052322, FBgn0060245" tRNA_gene GAG codon-amino acid adaptor activity ; GO:0033460 | inferred from sequence model translation ; GO:0006412 | inferred by curator from GO:0033460 cytosol ; GO:0005829 | inferred by curator from GO:0033460 "glu-trna, AE002584.trna11-GluCTC, tRNA:E4, tRNA:E:CTC:AE002584-i, tRNA:glu4:62Ae, CR32322, tRNA:Glu, chr3L.trna11-GluCTC, tRNA:Glu-CTC-3-9, tRNA:E4:62Ae, tRNA-Glu-CTC-3-9, GAG" - CR32322 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0028138 l(3)S048318 lethal (3) S048318 http://flybase.org/reports/FBgn0028138 gene - - - "0483/18, l(3)S048318" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0264467 asRNA:CR43875 - http://flybase.org/reports/FBgn0264467 non_protein_coding_gene - - - CR43875 - CR43875 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0069249 attP:Dps2 pseudo attP recognition site Dps2 http://flybase.org/reports/FBgn0069249 region - - - attP:Dps2 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0267249 lncRNA:CR45689 - http://flybase.org/reports/FBgn0267249 non_protein_coding_gene - - - CR45689 - CR45689 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0010651 MFS14 Major Facilitator Superfamily Transporter 14 http://flybase.org/reports/FBgn0010651 FBgn0034393 protein_coding_gene transmembrane transporter activity ; GO:0022857 | inferred from biological aspect of ancestor with PANTHER:PTN000184222 "wing disc dorsal/ventral pattern formation ; GO:0048190 | inferred from genetic interaction with Bx, ap transmembrane transport ; GO:0055085 | inferred from biological aspect of ancestor with PANTHER:PTN000184222 anion transport ; GO:0006820 | inferred from biological aspect of ancestor with PANTHER:PTN000184222 response to hypoxia ; GO:0001666 | inferred from expression pattern inferred from mutant phenotype" integral component of membrane ; GO:0016021 | inferred from biological aspect of ancestor with PANTHER:PTN000184222 plasma membrane ; GO:0005886 | inferred from direct assay "CG15095, 8717, MFS14, l(2)08717, lethal (2) 08717, lethal(2)08717, l208717" "IPR011701:Major facilitator superfamily, IPR020846:Major facilitator superfamily domain" CG15095 27-Aug-18 DroID_v2018_08 "Drer\ppt1, Drer\si:ch1073-513e17.1, Drer\slc17a9a, Drer\slc17a5, Drer\slc17a8, Drer\slc17a6a, Drer\slc17a7a, Drer\slc17a6b" "Scer\YIL166C, Scer\DAL5, Scer\THI73, Scer\TNA1" "Cele\T02B11.6, Cele\T19D12.9, Cele\vglu-3, Cele\Y15E3A.4, Cele\F10C2.7, Cele\C01B4.7, Cele\slc-17.5, Cele\C01B4.8, Cele\slc-17.4, Cele\C18H9.5, Cele\F11A5.9, Cele\eat-4, Cele\C18D1.2, Cele\slc-17.2, Cele\F41C3.2, Cele\Y19D10A.11, Cele\T22F3.11, Cele\Y19D10A.5, Cele\F56A4.12, Cele\slc-17.3, Cele\F56A4.10, Cele\R10D12.1, Cele\T28H11.8, Cele\vglu-2, Cele\M162.5, Cele\H11E01.2, Cele\T01H3.3, Cele\F44E7.7, Cele\Y4C6B.4, Cele\T27D12.1, Cele\T22F3.10, Cele\cima-1, Cele\K08C7.1, Cele\T22F3.7, Cele\C35A5.3, Cele\T19D12.10, Cele\F59A1.13, Cele\slc-17.9, Cele\Y19D10A.8, Cele\C39E9.7, Cele\D1046.4, Cele\Y51B9A.6, Cele\slc-17.8, Cele\W04C9.6, Cele\Y19D10A.4, Cele\K11G9.5, Cele\Y4C6B.3, Cele\M117.1, Cele\slc-17.1, Cele\T22F3.8" Xtro\slc17a7 "Mmus\Slc17a2, Mmus\Slc17a3, Mmus\Slc17a7, Mmus\Slc17a6, Mmus\Slc17a1, Mmus\Slc17a8, Mmus\Slc17a5, Mmus\Slc17a4" "Hsap\SLC17A8, Hsap\SLC17A1, Hsap\SLC17A7, Hsap\SLC17A2, Hsap\SLC17A6, Hsap\SLC17A3, Hsap\SLC17A4, Hsap\SLC17A5" "viable,lethal,recessive" FBgn0036188 CG7339 - http://flybase.org/reports/FBgn0036188 protein_coding_gene RNA polymerase III activity ; GO:0001056 | contributes_to inferred from biological aspect of ancestor with PANTHER:PTN000295357 neurogenesis ; GO:0022008 | inferred from mutant phenotype transcription initiation from RNA polymerase III promoter ; GO:0006384 | inferred from biological aspect of ancestor with PANTHER:PTN000295357 DNA-directed RNA polymerase III complex ; GO:0005666 | inferred from biological aspect of ancestor with PANTHER:PTN000295357 "CG7339, lincRNA.S4825" "IPR005576:RNA polymerase Rpb7, N-terminal, IPR013238:RNA polymerase III, subunit Rpc25, IPR012340:Nucleic acid-binding, OB-fold" CG7339 27-Aug-18 DroID_v2018_08 Drer\polr3h Scer\RPC25 Cele\rpc-25 Xtro\polr3h Mmus\Polr3h Hsap\POLR3H "lethal,neuroanatomy defective,lethal - all die before end of pupal stage,some die during pupal stage" "embryonic/larval neuroblast,ganglion mother cell" FBgn0051866 Ada1-2 transcriptional Adaptor 1-2 http://flybase.org/reports/FBgn0051866 protein_coding_gene transcription coactivator activity ; GO:0003713 | inferred from biological aspect of ancestor with PANTHER:PTN001083423 histone acetyltransferase activity ; GO:0004402 | contributes_to inferred from direct assay transcription coactivator activity ; GO:0003713 | inferred from sequence or structural similarity with SGD:S000006175 regulation of transcription from RNA polymerase II promoter ; GO:0006357 | inferred from biological aspect of ancestor with PANTHER:PTN001083423 histone acetylation ; GO:0016573 | inferred from sequence or structural similarity with SGD:S000006175 histone H3 acetylation ; GO:0043966 | inferred from direct assay transcription from RNA polymerase II promoter ; GO:0006366 | inferred from sequence or structural similarity with SGD:S000006175 SAGA complex ; GO:0000124 | inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay "Ada1-2, CG31866, Ada1, ada1-2" IPR024738:Transcriptional coactivator Hfi1/Transcriptional adapter 1 CG31866 27-Aug-18 DroID_v2018_08 Drer\tada1 Scer\HFI1 - Xtro\tada1 Mmus\Tada1 Hsap\TADA1 FBgn0041236 Gr59d Gustatory receptor 59d http://flybase.org/reports/FBgn0041236 protein_coding_gene olfactory receptor activity ; GO:0004984 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 taste receptor activity ; GO:0008527 | inferred from sequence or structural similarity taste receptor activity ; GO:0008527 | non-traceable author statement sweet taste receptor activity ; GO:0033041 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 chemosensory behavior ; GO:0007635 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 sensory perception of taste ; GO:0050909 | non-traceable author statement sensory perception of taste ; GO:0050909 | inferred from sequence or structural similarity sensory perception of bitter taste ; GO:0050913 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 sensory perception of pain ; GO:0019233 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 male courtship behavior ; GO:0008049 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 response to carbon dioxide ; GO:0010037 | inferred from biological aspect of ancestor with PANTHER:PTN001080220 integral component of membrane ; GO:0016021 | inferred from electronic annotation with InterPro:IPR013604 neuronal cell body ; GO:0043025 | inferred from biological aspect of ancestor with PANTHER:PTN000475107 dendrite ; GO:0030425 | inferred from biological aspect of ancestor with PANTHER:PTN000475107 integral component of membrane ; GO:0016021 | non-traceable author statement axon ; GO:0030424 | inferred from biological aspect of ancestor with PANTHER:PTN000475107 "CG30330, Gr59D1, 59D1, 59D.1, GR59D.1, CG13543, Gr59d, GR59d" IPR013604:7TM chemoreceptor CG30330 27-Aug-18 DroID_v2018_08 - - "Cele\gur-3, Cele\lite-1" - - - viable FBgn0032800 CG10137 - http://flybase.org/reports/FBgn0032800 protein_coding_gene - - - CG10137 IPR008979:Galactose-binding domain-like CG10137 27-Aug-18 DroID_v2018_08 "Drer\ace, Drer\ace2, Drer\cep104" - "Cele\T06D8.2, Cele\C40H1.3, Cele\F28C6.9, Cele\C06A8.8" "Xtro\ace2, Xtro\cep104, Xtro\ace" "Mmus\Ace, Mmus\Ace3, Mmus\Cep104, Mmus\Ace2" "Hsap\ACE2, Hsap\ACE, Hsap\CEP104" viable FBgn0013696 mt:tRNA:Ile-GAT mitochondrial transfer RNA:Isoleucine-GAT http://flybase.org/reports/FBgn0013696 FBgn0002867 tRNA_gene - - - "CR34060, tRNA[Ile], mtdbD00006292, mt:tRNA:Ile-GAT, mt:tRNA:I, mt:tRNA[Ile]" - CR34060 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0039893 CG13301 - http://flybase.org/reports/FBgn0039893 protein_coding_gene - - - CG13301 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0262882 CG43237 - http://flybase.org/reports/FBgn0262882 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG43237, lincRNA.333" - CG43237 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0020806 ms(2)C32 ms(2)C32 http://flybase.org/reports/FBgn0020806 - gene - - - "2-C32, ms(2)C32" - - 27-Aug-18 DroID_v2018_08 - - - - - - "male sterile,recessive,chemical sensitive" FBgn0266637 asRNA:CR45144 - http://flybase.org/reports/FBgn0266637 non_protein_coding_gene - - - CR45144 - CR45144 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0010948 l(3)10621 lethal (3) 10621 http://flybase.org/reports/FBgn0010948 - gene - - - l(3)10621 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive,partially lethal - majority die" FBgn0005502 slf schlaff http://flybase.org/reports/FBgn0005502 "FBgn0001912, FBgn0003422" gene molecular_function ; GO:0003674 | no biological data available embryonic development via the syncytial blastoderm ; GO:0001700 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available "l(2)25Aa, slf" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of embryonic stage,recessive,some die during embryonic stage" "embryonic/first instar larval cuticle,cephalopharyngeal skeleton,embryo,posterior,anterior" FBgn0043899 gsb::Mmus\Pax3 Pax3 http://flybase.org/reports/FBgn0043899 engineered_fusion_gene - - - gsb::Mmus\Pax3 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0067072 Mns Microtubule nucleation suppressor http://flybase.org/reports/FBgn0067072 gene - - - "MINUS, Minus, Mns" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0031145 Ntf-2 Nuclear transport factor-2 http://flybase.org/reports/FBgn0031145 protein_coding_gene - transport ; GO:0006810 | inferred from electronic annotation with InterPro:IPR002075 positive regulation of antimicrobial peptide biosynthetic process ; GO:0002807 | inferred from mutant phenotype intracellular ; GO:0005622 | inferred from electronic annotation with InterPro:IPR002075 "DNTF-2, NTF-2, ntf2, Dntf-2, Dntf2, CG1740, dmNTF2, l(1)G0086, l(1)G0125, l(1)G0428, l(1)G0337, BcDNA:GM08921, Ntf-2, ntf-2, Ntf2" "IPR018222:Nuclear transport factor 2, eukaryote, IPR002075:Nuclear transport factor 2, IPR032710:NTF2-like domain" CG1740 27-Aug-18 DroID_v2018_08 "Drer\nutf2, Drer\nutf2l" Scer\NTF2 Cele\ran-4 Xtro\nutf2 "Mmus\Nutf2-ps2, Mmus\Nutf2" Hsap\NUTF2 " adult stage | male , adult stage | female " testis

"lethal,female,lethal - all die before end of larval stage,some die during larval stage,female fertile,viable,male,male fertile,visible,recessive,lethal - all die before end of embryonic stage,some die during embryonic stage,some die during third instar larval stage,partially lethal - majority die,some die during pupal stage,female sterile" "eye,mesothoracic tergum" FBgn0014966 gypsy\pol gypsy\polymerase http://flybase.org/reports/FBgn0014966 - transposable_element_gene nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR012337 DNA integration ; GO:0015074 | inferred from electronic annotation with InterPro:IPR001584 - "DmeGypV int, ORF2, int, gypsy\pol, pol, RTase, RT" "IPR021109:Aspartic peptidase domain, IPR000477:Reverse transcriptase domain, IPR001584:Integrase, catalytic core, IPR012337:Ribonuclease H-like domain" - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0032723 ssp3 short spindle 3 http://flybase.org/reports/FBgn0032723 protein_coding_gene - - spindle ; GO:0005819 | colocalizes_with inferred from direct assay "CG10666, ssp3, CG18397, Ssp3" "IPR032446:S phase cyclin A-associated protein in the endoplasmic reticulum, N-terminal" CG18397 27-Aug-18 DroID_v2018_08 Drer\scaper - Cele\Y6B3B.4 Xtro\scaper Mmus\Scaper Hsap\SCAPER "viable,fertile" FBgn0067055 Q9 Q9 http://flybase.org/reports/FBgn0067055 gene - - - Q9 - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,lethal,viable" chaeta FBgn0036987 CG5274 - http://flybase.org/reports/FBgn0036987 protein_coding_gene - - - CG5274 IPR027844:Protein of unknown function DUF4507 CG5274 27-Aug-18 DroID_v2018_08 Drer\zgc:56409 - Cele\Y56A3A.31 Xtro\c7orf26 Mmus\E130309D02Rik Hsap\C7orf26 "viable,fertile" DRSC11774 I 1.6241633 -0.55302344 0.020185487 0.360656914 0.208308987 0.300474956 FBgn0044123 E(rst)B50 E(rst)B50 http://flybase.org/reports/FBgn0044123 gene molecular_function ; GO:0003674 | no biological data available compound eye morphogenesis ; GO:0001745 | inferred from genetic interaction with rst cellular_component ; GO:0005575 | no biological data available "B50, E(rst)B50" - - 27-Aug-18 DroID_v2018_08 - - - - - - viable "eye,cone cell,primary pigment cell,secondary pigment cell,ectopic,tertiary pigment cell,interommatidial bristle" FBgn0028025 l(3)S103603 lethal (3) S103603 http://flybase.org/reports/FBgn0028025 gene - - - "1036/03, l(3)S103603" - - 27-Aug-18 DroID_v2018_08 - - - - - - "partially lethal - majority die,recessive,lethal" FBgn0041839 E(Sev-CycE)G66 E(Sev-CycE)G66 http://flybase.org/reports/FBgn0041839 gene - - - E(Sev-CycE)G66 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0267091 asRNA:CR45535 - http://flybase.org/reports/FBgn0267091 non_protein_coding_gene - - - CR45535 - CR45535 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0014376 ptz pitzi http://flybase.org/reports/FBgn0014376 - gene - - - ptz - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0260032 siren2 siren 2 http://flybase.org/reports/FBgn0260032 gene - - - siren2 - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,somatic clone" "wing,somatic clone" FBgn0024666 l(2)k05510 lethal (2) k05510 http://flybase.org/reports/FBgn0024666 - gene - - - "55/10, l(2)k05510" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" imaginal disc FBgn0003497 Sq Squat http://flybase.org/reports/FBgn0003497 - gene - - - Sq - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" "leg,head,adult thorax" FBgn0031092 CG9577 - http://flybase.org/reports/FBgn0031092 protein_coding_gene catalytic activity ; GO:0003824 | inferred from electronic annotation with InterPro:IPR001753 metabolic process ; GO:0008152 | inferred from electronic annotation with InterPro:IPR001753 fatty acid beta-oxidation ; GO:0006635 | non-traceable author statement peroxisome ; GO:0005777 | inferred from sequence model lipid particle ; GO:0005811 | inferred from direct assay CG9577 "IPR001753:Crotonase superfamily, IPR014748:Crontonase, C-terminal, IPR029045:ClpP/crotonase-like domain" CG9577 27-Aug-18 DroID_v2018_08 Drer\ech1 "Scer\DCI1, Scer\ECI1" "Cele\Y25C1A.13, Cele\F58A6.1" Xtro\ech1 Mmus\Ech1 Hsap\ECH1 viable FBgn0263094 CG43362 - http://flybase.org/reports/FBgn0263094 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG43362 - CG43362 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0066357 l(2)23CDg lethal (2) 23CDg http://flybase.org/reports/FBgn0066357 gene - - - l(2)23CDg - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0035073 CG16896 - http://flybase.org/reports/FBgn0035073 protein_coding_gene GTPase activator activity ; GO:0005096 | inferred from sequence or structural similarity with Evi5 regulation of GTPase activity ; GO:0043087 | inferred from sequence or structural similarity with Evi5 centrosome ; GO:0005813 | inferred from biological aspect of ancestor with PANTHER:PTN001068643 CG16896 "IPR015943:WD40/YVTN repeat-like-containing domain, IPR000195:Rab-GTPase-TBC domain" CG16896 27-Aug-18 DroID_v2018_08 Drer\tbc1d31 - - Xtro\tbc1d31 Mmus\Tbc1d31 Hsap\TBC1D31 viable FBgn0013657 ms(2)neo2 ms(2)neo2 http://flybase.org/reports/FBgn0013657 - gene - - - ms(2)neo2 - - 27-Aug-18 DroID_v2018_08 - - - - - - male sterile FBgn0260740 Grip98 - http://flybase.org/reports/FBgn0260740 protein_coding_gene - - - "Grip98, Dgrip98, GCP3" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0086904 Nacalpha Nascent polypeptide associated complex protein alpha subunit http://flybase.org/reports/FBgn0086904 protein_coding_gene protein binding ; GO:0005515 | inferred from physical interaction with UniProtKB:Q9U9Q7 neurogenesis ; GO:0022008 | inferred from mutant phenotype oogenesis ; GO:0048477 | inferred from mutant phenotype - "aic, alphaNAC, alpha-NAC, NAC, l(2)04329, CG8759, Nacalpha, NACalpha" "IPR002715:Nascent polypeptide-associated complex NAC domain, IPR016641:Nascent polypeptide-associated complex subunit alpha" CG8759 27-Aug-18 DroID_v2018_08 "Drer\naca, Drer\nacad" Scer\EGD2 Cele\icd-2 "Xtro\naca, Xtro\naca.2" "Mmus\Naca, Mmus\Nacad" "Hsap\NACA, Hsap\NACA2, Hsap\NACAD" FBgn0034204 CG10953 - http://flybase.org/reports/FBgn0034204 protein_coding_gene - - - "CG10953, CG10953-PA" IPR004011:GYR motif CG10953 27-Aug-18 DroID_v2018_08 - - - - Mmus\Sprr3 - "visible,partially lethal - majority die,some die during pupal stage,viable" "trichogen cell,mesothoracic tergum" FBgn0259238 CG42336 - http://flybase.org/reports/FBgn0259238 protein_coding_gene - - - "CG42336, CG13210, BcDNA:AT13707, CG13211" - CG42336 27-Aug-18 DroID_v2018_08 - - Cele\C48B6.10 - - - FBgn0030327 FucT6 "alpha1,6-fucosyltransferase" http://flybase.org/reports/FBgn0030327 protein_coding_gene alpha-(1->6)-fucosyltransferase activity ; GO:0046921 | inferred from direct assay glycoprotein 6-alpha-L-fucosyltransferase activity ; GO:0008424 | inferred from sequence or structural similarity with UniProtKB:Q9BYC5 protein glycosylation in Golgi ; GO:0033578 | inferred from electronic annotation with InterPro:IPR015827 protein N-linked glycosylation ; GO:0006487 | inferred from biological aspect of ancestor with PANTHER:PTN000992822 N-glycan fucosylation ; GO:0036071 | inferred from biological aspect of ancestor with PANTHER:PTN000992822 GDP-L-fucose metabolic process ; GO:0046368 | inferred from sequence or structural similarity with UniProtKB:Q9BYC5 protein N-linked glycosylation via asparagine ; GO:0018279 | inferred from sequence or structural similarity with UniProtKB:Q9BYC5 integral component of membrane ; GO:0016021 | inferred from electronic annotation with InterPro:IPR015827 Golgi cisterna membrane ; GO:0032580 | inferred from electronic annotation with InterPro:IPR015827 "Fuc-TVIII, CG2448, CK00490, BEST:CK00490, FucT6, Dm alpha1,6-FucT, dalpha6Fut" "IPR001452:SH3 domain, IPR015827:Alpha-(1,6)-fucosyltransferase, eukaryotic type, IPR027350:Glycosyltransferase family 23 (GT23) domain" CG2448 27-Aug-18 DroID_v2018_08 "Drer\fut8a, Drer\fut8b" - Cele\fut-8 Xtro\fut8 Mmus\Fut8 Hsap\FUT8 "viable,fertile,immune response defective" FBgn0265694 lncRNA:CR44501 - http://flybase.org/reports/FBgn0265694 non_protein_coding_gene - - - "lincRNA.962, CR44501" - CR44501 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0281841 T:cic cic fragment http://flybase.org/reports/FBgn0281841 engineered_tag - - - T:cic - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0004850 Su(var)204 Suppressor of variegation 204 http://flybase.org/reports/FBgn0004850 - gene - - - "Su(var)204, 204" - - 27-Aug-18 DroID_v2018_08 - - - - - - "viable,suppressor of variegation,dominant,non-suppressor of variegation" FBgn0011849 tRNA:Glu-TTC-1-5 transfer RNA:Glutamic acid-TTC 1-5 http://flybase.org/reports/FBgn0011849 "FBgn0003771, FBgn0011846, FBgn0050455, FBgn0060240" tRNA_gene GAA codon-amino acid adaptor activity ; GO:0033459 | inferred from sequence model translation ; GO:0006412 | inferred by curator from GO:0033459 cytosol ; GO:0005829 | inferred by curator from GO:0033459 "CR30455, glu-tRNA-4, AE002787.trna5-GluTTC, tRNA:E4, tRNA:E:TTC:AE002787-b, tRNA:glu4:56Fb, tRNA:Glu, chr2R.trna63-GluTTC, tRNA:Glu-TTC-1-5, tRNA:E4:56Fb, tRNA-Glu-TTC-1-5, GAA" - CR30455 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0033540 Elp2 Elongator complex protein 2 http://flybase.org/reports/FBgn0033540 protein_coding_gene microtubule binding ; GO:0008017 | inferred from biological aspect of ancestor with PANTHER:PTN000752735 endopeptidase activator activity ; GO:0061133 | inferred from sequence or structural similarity with UniProtKB:Q16186 transcription elongation from RNA polymerase II promoter ; GO:0006368 | inferred from sequence or structural similarity with UniProtKB:Q16186 proteasome assembly ; GO:0043248 | inferred from sequence or structural similarity with UniProtKB:Q16186 cell cortex ; GO:0005938 | inferred from biological aspect of ancestor with PANTHER:PTN000752735 microtubule associated complex ; GO:0005875 | inferred from biological aspect of ancestor with PANTHER:PTN000752735 microtubule ; GO:0005874 | inferred from biological aspect of ancestor with PANTHER:PTN000752735 kinetochore ; GO:0000776 | inferred from biological aspect of ancestor with PANTHER:PTN000752735 centrosome ; GO:0005813 | inferred from biological aspect of ancestor with PANTHER:PTN000752735 proteasome complex ; GO:0000502 | inferred from sequence or structural similarity with UniProtKB:Q16186 "CG1187, CG11887, Stip, elp-2, D-elp2, Elp2, StIP" "IPR001680:WD40 repeat, IPR019775:WD40 repeat, conserved site, IPR017986:WD40-repeat-containing domain, IPR015943:WD40/YVTN repeat-like-containing domain" CG11887 27-Aug-18 DroID_v2018_08 "Drer\elp2, Drer\nwd1" Scer\ELP2 Cele\elpc-2 Xtro\elp2 Mmus\Elp2 Hsap\ELP2 "visible,partially lethal - majority die,some die during pupal stage" trichogen cell FBgn0029039 l(2)G56 lethal (2) G56 http://flybase.org/reports/FBgn0029039 gene - - - "G56, l(2)G56" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0035407 Asciz ASCIZ zinc finger protein http://flybase.org/reports/FBgn0035407 protein_coding_gene nucleic acid binding ; GO:0003676 | inferred from electronic annotation with InterPro:IPR013087 positive regulation of transcription from RNA polymerase II promoter ; GO:0045944 | inferred from mutant phenotype regulation of mitotic nuclear division ; GO:0007088 | inferred from mutant phenotype metamorphosis ; GO:0007552 | inferred from mutant phenotype polytene chromosome interband ; GO:0005705 | inferred from direct assay spindle matrix ; GO:1990047 | inferred from direct assay polytene chromosome puff ; GO:0005703 | inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay "Asciz, dASCIZ, CG14962, CC15, Digitor" IPR013087:Zinc finger C2H2-type CG14962 27-Aug-18 DroID_v2018_08 "Drer\znf142, Drer\im:7147486, Drer\atmin" Scer\RME1 "Cele\zfp-2, Cele\C34H4.5, Cele\pag-3" Xtro\atmin "Mmus\Zbtb41, Mmus\Atmin, Mmus\Zfp142, Mmus\Zfp574" "Hsap\ZBTB41, Hsap\ZNF142, Hsap\ATMIN, Hsap\IKZF5, Hsap\ZNF574" "visible,mitotic cell cycle defective,increased cell death,lethal - all die during first instar larval stage,viable" "wing,posterior compartment,wing disc,somatic clone" FBgn0005118 l(1)FMb lethal (1) FMb http://flybase.org/reports/FBgn0005118 - gene - - - l(1)FMb - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0065938 l(2)SH0120 lethal (2) SH0120 http://flybase.org/reports/FBgn0065938 gene - - - "l(2)SH0120, l(2)SH2 0120" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0036778 Cyp312a1 Cyp312a1 http://flybase.org/reports/FBgn0036778 protein_coding_gene "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ; GO:0016705 | inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002403 heme binding ; GO:0020037 | inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002403 iron ion binding ; GO:0005506 | inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002403 monooxygenase activity ; GO:0004497 | inferred from electronic annotation with InterPro:IPR002403" "oxidation-reduction process ; GO:0055114 | inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002403" - "312a1, CG5137, Cyp312a1, P450 IV" "IPR001128:Cytochrome P450, IPR002403:Cytochrome P450, E-class, group IV" CG5137 27-Aug-18 DroID_v2018_08 "Drer\cyp1c1, Drer\cyp4t8, Drer\cyp26c1, Drer\cyp46a1.3, Drer\LOC100329425, Drer\cyp46a1.4, Drer\cyp4f3, Drer\cyp4v8, Drer\cyp4v7, Drer\cyp19a1a, Drer\cyp46a1.2, Drer\cyp1b1, Drer\cyp21a2, Drer\cyp26a1, Drer\cyp26b1, Drer\cyp1d1, Drer\cyp19a1b, Drer\cyp46a1.1, Drer\cyp20a1" "Scer\ERG11, Scer\ERG5, Scer\DIT2" "Cele\cyp-37A1, Cele\cyp-32A1, Cele\cyp-29A4, Cele\cyp-37B1, Cele\cyp-29A2, Cele\cyp-42A1, Cele\cyp-29A3, Cele\cyp-32B1, Cele\cyp-31A2, Cele\cyp-31A5, Cele\cyp-31A3" "Xtro\cyp26c1, Xtro\cyp1a1, Xtro\cyp4f2, Xtro\cyp20a1, Xtro\cyp4b1.2, Xtro\mgc108213, Xtro\LOC100488227, Xtro\cyp4f22, Xtro\cyp19a1, Xtro\cyp4v2, Xtro\LOC100487918, Xtro\cyp26a1, Xtro\cyp4b1, Xtro\cyp26b1" "Mmus\Cyp26c1, Mmus\Cyp51, Mmus\Cyp4b1, Mmus\Cyp20a1, Mmus\Cyp4a12a, Mmus\Cyp4f15, Mmus\Cyp4a29, Mmus\Cyp4f13, Mmus\Cyp4f17, Mmus\Cyp4a10, Mmus\Cyp4a30b, Mmus\Cyp4f14, Mmus\Cyp46a1, Mmus\Cyp4a12b, Mmus\Cyp4a31, Mmus\Cyp26a1, Mmus\Cyp4a14, Mmus\Cyp4f37, Mmus\Cyp4f39, Mmus\Cyp4v3, Mmus\Cyp4x1, Mmus\Cyp26b1, Mmus\Cyp4a32, Mmus\Cyp19a1, Mmus\Cyp4f18, Mmus\Cyp4f16, Mmus\Cyp4f40" "Hsap\CYP20A1, Hsap\CYP46A1, Hsap\CYP4F2, Hsap\CYP4Z1, Hsap\CYP4X1, Hsap\CYP4A11, Hsap\CYP4A22, Hsap\CYP4F8, Hsap\CYP51A1, Hsap\CYP19A1, Hsap\CYP4V2, Hsap\CYP4F11, Hsap\CYP26B1, Hsap\CYP26C1, Hsap\CYP4F22, Hsap\CYP4F12, Hsap\CYP26A1, Hsap\CYP4B1, Hsap\CYP4F3" viable FBgn0005293 mei-2245 meiotic 2245 http://flybase.org/reports/FBgn0005293 - gene - - - "2245, mei-2245" - - 27-Aug-18 DroID_v2018_08 - - - - - - "meiotic cell cycle defective,recessive" meiosis & nuclear chromosome FBgn0040909 CG12686 - http://flybase.org/reports/FBgn0040909 protein_coding_gene - - - CG12686 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0039500 CG5984 - http://flybase.org/reports/FBgn0039500 protein_coding_gene actin binding ; GO:0003779 | inferred from sequence or structural similarity - - CG5984 "IPR001298:Filamin/ABP280 repeat, IPR013783:Immunoglobulin-like fold, IPR014756:Immunoglobulin E-set, IPR017868:Filamin/ABP280 repeat-like" CG5984 27-Aug-18 DroID_v2018_08 "Drer\flna, Drer\flnb, Drer\flnca, Drer\LOC100534866, Drer\flncb, Drer\flnbl" - Cele\fln-1 "Xtro\flnb, Xtro\flnc, Xtro\flna" "Mmus\Flnc, Mmus\Flna, Mmus\Flnb" "Hsap\FLNC, Hsap\FLNB, Hsap\FLNA" FBgn0053234 CG33234 - http://flybase.org/reports/FBgn0053234 protein_coding_gene substrate-specific transmembrane transporter activity ; GO:0022891 | inferred from biological aspect of ancestor with PANTHER:PTN000756324 transmembrane transport ; GO:0055085 | inferred from electronic annotation with InterPro:IPR011701 integral component of plasma membrane ; GO:0005887 | inferred from biological aspect of ancestor with PANTHER:PTN000628500 "CG12036, CG33234" "IPR011701:Major facilitator superfamily, IPR020846:Major facilitator superfamily domain" CG33234 27-Aug-18 DroID_v2018_08 "Drer\slc22a7b.1, Drer\sv2ba, Drer\sv2a, Drer\slc22a7b.3, Drer\zmp:0000001102, Drer\slc22a13, Drer\slc22a21, Drer\LOC100334012, Drer\sv2bb, Drer\sv2c, Drer\slc22a5, Drer\LOC101884074, Drer\sv2, Drer\zgc:175176, Drer\slc22a6l, Drer\oatx, Drer\slc22a7b.2" "Scer\DTR1, Scer\YHK8, Scer\QDR1, Scer\AQR1, Scer\QDR3, Scer\TPO3, Scer\TPO1, Scer\FLR1, Scer\TPO2, Scer\GIT1, Scer\QDR2" "Cele\T12B3.2, Cele\F23F12.13, Cele\K11D9.3, Cele\F23F12.3, Cele\C44C10.3, Cele\svop-1" "Xtro\slc22a6, Xtro\sv2b" "Mmus\Slc22a20, Mmus\Slc22a28, Mmus\Slc22a14, Mmus\Slc22a22, Mmus\Slc22a26, Mmus\Sv2b, Mmus\Slc22a4, Mmus\Slc22a19, Mmus\Slc22a27, Mmus\Slc22a8, Mmus\Slc22a29, Mmus\Svop, Mmus\Slc22a16, Mmus\Slc22a6, Mmus\Slc22a2, Mmus\Slc22a23, Mmus\Slc22a30, Mmus\Sv2c, Mmus\Slc22a7, Mmus\Sv2a" "Hsap\SLC22A25, Hsap\SV2B, Hsap\SVOP, Hsap\SV2C, Hsap\SLC22A1, Hsap\SV2A, Hsap\SLC22A12, Hsap\SLC22A7, Hsap\SLC22A10, Hsap\SLC22A9, Hsap\SLC22A8, Hsap\SLC22A24, Hsap\SLC22A23, Hsap\SLC22A11, Hsap\SLC22A6, Hsap\SLC22A2" FBgn0085271 CG34242 - http://flybase.org/reports/FBgn0085271 protein_coding_gene - - - CG34242 IPR027917:Protein of unknown function DUF4538 CG34242 27-Aug-18 DroID_v2018_08 Drer\smim20 - - - Mmus\Smim20 Hsap\SMIM20 FBgn0000846 fs(1)M33 female sterile (1) M33 http://flybase.org/reports/FBgn0000846 - gene - - - fs(1)M33 - - 27-Aug-18 DroID_v2018_08 - - - - - - female sterile chorion FBgn0061027 l(3)S024706b lethal (3) S024706b http://flybase.org/reports/FBgn0061027 gene - - - "0247/06, l(3)S024706b" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0266175 pre-mod(mdg4)-P - http://flybase.org/reports/FBgn0266175 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "pre-mod(mdg4)-P, CG44881" "IPR007588:Zinc finger, FLYWCH-type" CG44881 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0028693 Rpn12 Regulatory particle non-ATPase 12 http://flybase.org/reports/FBgn0028693 protein_coding_gene molecular_function ; GO:0003674 | no biological data available neurogenesis ; GO:0022008 | inferred from mutant phenotype ubiquitin-dependent protein catabolic process ; GO:0006511 | inferred from sequence or structural similarity with SGD:S000001948 proteasome-mediated ubiquitin-dependent protein catabolic process ; GO:0043161 | inferred by curator from GO:0000502 proteasome assembly ; GO:0043248 | inferred from biological aspect of ancestor with PANTHER:PTN000273181 proteasome-mediated ubiquitin-dependent protein catabolic process ; GO:0043161 | inferred from mutant phenotype "proteasome regulatory particle ; GO:0005838 | inferred from sequence or structural similarity with HGNC:9566 inferred from direct assay nucleus ; GO:0005634 | inferred from biological aspect of ancestor with PANTHER:PTN000273181 proteasome complex ; GO:0000502 | inferred from direct assay proteasome regulatory particle, lid subcomplex ; GO:0008541 | inferred from biological aspect of ancestor with PANTHER:PTN000273181 cytosol ; GO:0005829 | inferred from biological aspect of ancestor with PANTHER:PTN000273181 proteasome regulatory particle, lid subcomplex ; GO:0008541 | inferred from sequence or structural similarity with SGD:S000001948" "dRpn12, p30, CG4157, Rpn12, S14" "IPR006746:26S proteasome non-ATPase regulatory subunit Rpn12, IPR011991:Winged helix-turn-helix DNA-binding domain, IPR033464:CSN8/PSMD8/EIF3K" CG4157 27-Aug-18 DroID_v2018_08 Drer\psmd8 Scer\RPN12 Cele\rpn-12 Xtro\psmd8 Mmus\Psmd8 Hsap\PSMD8 "lethal,neuroanatomy defective" "embryonic/larval neuroblast,ganglion mother cell" DRSC11275 IEK -2.898831702 -3.190066818 -2.817372184 -1.933076306 1.385172297 -2.642958187 FBgn0011045 l(1)Stark-d lethal (1) of Stark d http://flybase.org/reports/FBgn0011045 FBgn0010212 gene - - - "l(1)Stark-d, l(1)Sd" - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0029955 CG15478 - http://flybase.org/reports/FBgn0029955 protein_coding_gene - - - CG15478 IPR015943:WD40/YVTN repeat-like-containing domain CG15478 27-Aug-18 DroID_v2018_08 - - - - - - "viable,fertile,visible,partially lethal - majority die,some die during pupal stage" "heart primordium,chaeta,supernumerary" FBgn0051648 CG31648 - http://flybase.org/reports/FBgn0051648 protein_coding_gene copper ion binding ; GO:0005507 | inferred from sequence or structural similarity with SGD:S000006053 aerobic respiration ; GO:0009060 | inferred from sequence or structural similarity with SGD:S000006053 respiratory chain complex IV assembly ; GO:0008535 | inferred from sequence or structural similarity with UniProtKB:Q9Y6N1 - "CG6922, CG31648, COXZ" "IPR007533:Cytochrome c oxidase assembly protein CtaG/Cox11, IPR023471:Cytochrome c oxidase assembly protein CtaG/Cox11, domain" CG31648 27-Aug-18 DroID_v2018_08 Drer\cox11 Scer\COX11 Cele\cox-11 Xtro\cox11 Mmus\Cox11 Hsap\COX11 "viable,visible" trichogen cell FBgn0067040 W10 W10 http://flybase.org/reports/FBgn0067040 gene - - - W10 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,viable" FBgn0023096 btv beethoven http://flybase.org/reports/FBgn0023096 FBgn0032657 protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR011704 ATPase activity, coupled ; GO:0042623 | inferred from sequence or structural similarity ATP-dependent microtubule motor activity, minus-end-directed ; GO:0008569 | inferred from sequence or structural similarity with UniProtKB:A8JDH8" "male courtship behavior ; GO:0008049 | inferred from mutant phenotype male courtship behavior, veined wing generated song production ; GO:0045433 | inferred from mutant phenotype adult walking behavior ; GO:0007628 | inferred from mutant phenotype intraciliary retrograde transport ; GO:0035721 | inferred from mutant phenotype sensory perception of sound ; GO:0007605 | inferred from mutant phenotype auditory behavior ; GO:0031223 | inferred from mutant phenotype microtubule-based movement ; GO:0007018 | inferred from sequence or structural similarity" cytoplasmic dynein complex ; GO:0005868 | inferred from sequence or structural similarity axoneme ; GO:0005930 | inferred from mutant phenotype cytoplasmic dynein complex ; GO:0005868 | inferred from sequence or structural similarity with UniProtKB:P36022 "CG15148, DHC, Dhc36D, DHC36D, btv, DHC2" "IPR004273:Dynein heavy chain domain, IPR011704:ATPase, dynein-related, AAA domain, IPR013594:Dynein heavy chain, domain-1, IPR013602:Dynein heavy chain, domain-2, IPR003593:AAA+ ATPase domain, IPR024317:Dynein heavy chain, P-loop containing D4 domain, IPR024743:Dynein heavy chain, coiled coil stalk, IPR026815:Cytoplasmic dynein 2 heavy chain 1, IPR026983:Dynein heavy chain, IPR027417:P-loop containing nucleoside triphosphate hydrolase" CG15148 27-Aug-18 DroID_v2018_08 "Drer\dnah12, Drer\dnah7, Drer\dnah9l, Drer\si:dkeyp-86b9.1, Drer\wu:fj30b09, Drer\dnah3, Drer\dnah2, Drer\si:dkeyp-87a6.1, Drer\dnah1, Drer\dync1h1, Drer\dnah7l" Scer\DYN1 "Cele\che-3, Cele\dhc-1" "Xtro\dnah14, Xtro\dnah2, Xtro\dnah7" "Mmus\Dnah12, Mmus\Dnah8, Mmus\Dync1h1, Mmus\Dnah1, Mmus\Dnah5, Mmus\Dnah9, Mmus\Dnah6, Mmus\Dnah7a, Mmus\Dnah10, Mmus\Dnah3, Mmus\Dync2h1, Mmus\Dnah17, Mmus\Dnah7b, Mmus\Dnah7c, Mmus\Dnah2, Mmus\Dnah11, Mmus\Dnhd1" "Hsap\DNAH6, Hsap\DNAH8, Hsap\CCDC88B, Hsap\DNAH2, Hsap\DYNC1H1, Hsap\DNAH5, Hsap\DNAH9, Hsap\DNAH14, Hsap\DNHD1, Hsap\DNAH7, Hsap\DNAH12, Hsap\DNAH10, Hsap\DNAH1, Hsap\DNAH3, Hsap\DNAH17, Hsap\DNAH11, Hsap\DYNC2H1" "thermotaxis behavior defective,touch sensitivity defective,locomotor behavior defective,auditory perception defective,neuroanatomy defective,viable,smell perception defective,courtship behavior defective,male,male fertile,song defective,recessive,behavior defective" "abdominal lateral pentascolopidial chordotonal organ lch5 & scolopidium,arista,mechanosensory sensory organ,wing,adult antennal nerve" FBgn0265860 lncRNA:CR44649 - http://flybase.org/reports/FBgn0265860 non_protein_coding_gene - - - CR44649 - CR44649 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0031184 CG14615 - http://flybase.org/reports/FBgn0031184 protein_coding_gene "transferase activity, transferring acyl groups other than amino-acyl groups ; GO:0016747 | inferred from electronic annotation with InterPro:IPR013653" - - CG14615 "IPR016181:Acyl-CoA N-acyltransferase, IPR013653:FR47-like" CG14615 27-Aug-18 DroID_v2018_08 "Drer\si:dkey-76k16.5, Drer\si:ch73-106k19.2, Drer\si:dkey-76k16.6" - Cele\ZK185.3 - - Hsap\GLYATL3 viable FBgn0001018 fs(3)A9 female sterile (3) A9 http://flybase.org/reports/FBgn0001018 - gene - - - fs(3)A9 - - 27-Aug-18 DroID_v2018_08 - - - - - - "female sterile,recessive" female reproductive system FBgn0005093 fs(2)OWc5 female sterile (2) OWc5 http://flybase.org/reports/FBgn0005093 - gene - - - fs(2)OWc5 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0037726 CG9492 - http://flybase.org/reports/FBgn0037726 protein_coding_gene "ATP binding ; GO:0005524 | inferred from electronic annotation with InterPro:IPR011704 ATPase activity, coupled ; GO:0042623 | inferred from sequence or structural similarity ATP-dependent microtubule motor activity, minus-end-directed ; GO:0008569 | inferred from sequence or structural similarity with UniProtKB:A8JDH8" microtubule-based movement ; GO:0007018 | inferred from sequence or structural similarity cilium movement ; GO:0003341 | inferred from sequence or structural similarity with UniProtKB:A8JDH8 sensory perception of sound ; GO:0007605 | inferred from mutant phenotype outer dynein arm ; GO:0036157 | inferred from sequence or structural similarity with UniProtKB:Q8TE73 microtubule associated complex ; GO:0005875 | inferred from direct assay dynein complex ; GO:0030286 | inferred from sequence or structural similarity "CG9492, DHC3B" "IPR004273:Dynein heavy chain domain, IPR011704:ATPase, dynein-related, AAA domain, IPR013594:Dynein heavy chain, domain-1, IPR013602:Dynein heavy chain, domain-2, IPR027417:P-loop containing nucleoside triphosphate hydrolase, IPR003593:AAA+ ATPase domain, IPR024317:Dynein heavy chain, P-loop containing D4 domain, IPR024743:Dynein heavy chain, coiled coil stalk, IPR026983:Dynein heavy chain" CG9492 27-Aug-18 DroID_v2018_08 "Drer\dnah2, Drer\dnah1, Drer\dnah3, Drer\si:dkeyp-86b9.1, Drer\dnah9l, Drer\dnah7, Drer\dync1h1, Drer\dnah7l, Drer\si:dkeyp-87a6.1, Drer\dnah12, Drer\wu:fj30b09, Drer\dnah5" Scer\DYN1 "Cele\che-3, Cele\dhc-1" "Xtro\dnah14, Xtro\dnah5, Xtro\dnah2, Xtro\dnah7" "Mmus\Dnah1, Mmus\Dnah5, Mmus\Dnah8, Mmus\Dnah11, Mmus\Dnah7b, Mmus\Dnah7a, Mmus\Dnah17, Mmus\Dnah6, Mmus\Dnah10, Mmus\Dnah9, Mmus\Dync2h1, Mmus\Dnhd1, Mmus\Dync1h1, Mmus\Dnah12, Mmus\Dnah3, Mmus\Dnah2" "Hsap\DNAH17, Hsap\DNAH9, Hsap\DNAH7, Hsap\CCDC88B, Hsap\DNHD1, Hsap\DNAH6, Hsap\DYNC2H1, Hsap\DNAH8, Hsap\DNAH12, Hsap\DNAH14, Hsap\DNAH3, Hsap\DNAH1, Hsap\DNAH10, Hsap\DNAH2, Hsap\DYNC1H1, Hsap\DNAH11, Hsap\DNAH5" "auditory perception defective,neurophysiology defective" FBgn0262563 CG43103 - http://flybase.org/reports/FBgn0262563 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG43103, Dm_2R:55417" - CG43103 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0044101 E(rst)C532 E(rst)C532 http://flybase.org/reports/FBgn0044101 gene molecular_function ; GO:0003674 | no biological data available compound eye morphogenesis ; GO:0001745 | inferred from genetic interaction with rst cellular_component ; GO:0005575 | no biological data available "C532, E(rst)C532" - - 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0069427 JJF014 JJF014 http://flybase.org/reports/FBgn0069427 gene - - - JJF014 - - 27-Aug-18 DroID_v2018_08 - - - - - - stress response defective FBgn0029539 CG11663 - http://flybase.org/reports/FBgn0029539 protein_coding_gene - - - "BcDNA:AT05678, CG11663" IPR015943:WD40/YVTN repeat-like-containing domain CG11663 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0010179 tu(2)49k tu(2)49k http://flybase.org/reports/FBgn0010179 - gene - - - tu(2)49k - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,melanotic mass phenotype" melanotic mass FBgn0039675 ppk21 pickpocket 21 http://flybase.org/reports/FBgn0039675 protein_coding_gene sodium channel activity ; GO:0005272 | inferred from sequence or structural similarity with MGI:MGI:101782 sodium ion transport ; GO:0006814 | inferred from sequence or structural similarity with MGI:MGI:101782 integral component of membrane ; GO:0016021 | inferred from sequence or structural similarity with MGI:MGI:101782 "PPK21, CG12048, ppk21, Ppk21" IPR001873:Epithelial sodium channel CG12048 27-Aug-18 DroID_v2018_08 "Drer\asic1a, Drer\asic4b, Drer\asic1c, Drer\asic1b, Drer\asic2, Drer\asic4a" - "Cele\mec-10, Cele\del-10, Cele\egas-3, Cele\delm-2, Cele\unc-105, Cele\del-1, Cele\delm-1, Cele\asic-1, Cele\del-7, Cele\mec-4, Cele\egas-1, Cele\flr-1, Cele\deg-1, Cele\acd-4, Cele\degt-1, Cele\egas-2, Cele\unc-8, Cele\egas-4, Cele\acd-1, Cele\asic-2, Cele\del-4" "Xtro\asic5, Xtro\scnn1b, Xtro\scnn1d, Xtro\asic4, Xtro\scnn1a, Xtro\scnn1g, Xtro\asic1" "Mmus\Asic5, Mmus\Asic3, Mmus\Asic4, Mmus\Scnn1a, Mmus\Scnn1g, Mmus\Asic1, Mmus\Asic2, Mmus\Scnn1b" "Hsap\SCNN1G, Hsap\SCNN1B, Hsap\ASIC3, Hsap\ASIC1, Hsap\ASIC5, Hsap\SCNN1D, Hsap\ASIC2, Hsap\SCNN1A, Hsap\ASIC4" viable FBgn0037935 CG6834 - http://flybase.org/reports/FBgn0037935 protein_coding_gene myosin binding ; GO:0017022 | inferred from physical interaction with Myo10A - - CG6834 "IPR015897:CHK kinase-like, IPR004119:Protein of unknown function DUF227, IPR011009:Protein kinase-like domain" CG6834 27-Aug-18 DroID_v2018_08 - - "Cele\H06H21.8, Cele\nhr-246, Cele\F20D6.5" - - - "visible,partially lethal - majority die,some die during pupal stage" trichogen cell FBgn0002234 l(3)68Ba lethal (3) 68Ba http://flybase.org/reports/FBgn0002234 FBgn0002230 gene - - - "l(3)C141, A, l(3)A, l(3)68Ba" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive,lethal - all die before end of pupal stage,some die during pupal stage" FBgn0266493 s-108 - http://flybase.org/reports/FBgn0266493 gene - - - s-108 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0037044 CG10585 - http://flybase.org/reports/FBgn0037044 protein_coding_gene - isoprenoid biosynthetic process ; GO:0008299 | inferred from electronic annotation with InterPro:IPR000092 - CG10585 "IPR008949:Isoprenoid synthase domain, IPR000092:Polyprenyl synthetase" CG10585 27-Aug-18 DroID_v2018_08 "Drer\pdss2, Drer\pdss1" Scer\COQ1 - "Xtro\pdss1, Xtro\pdss2" "Mmus\Pdss2, Mmus\Pdss1" "Hsap\PDSS2, Hsap\PDSS1" "viable,fertile,lethal,partially lethal - majority die,visible" "embryonic/larval hemocyte | third instar larval stage,mesothoracic tergum" FBgn0267173 lncRNA:CR45613 - http://flybase.org/reports/FBgn0267173 non_protein_coding_gene - - - CR45613 - CR45613 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0020594 anon-57Cc anon-57Cc http://flybase.org/reports/FBgn0020594 - gene - - - anon-57Cc - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0058402 CG40402 - http://flybase.org/reports/FBgn0058402 protein_coding_gene - - - CG40402 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0010319 Cdi11 Cyclin-dependent kinase interactor 11 http://flybase.org/reports/FBgn0010319 - gene - - - "CDI11, cdi11, Cdi11" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0044002 Su(rst)C352 Su(rst)C352 http://flybase.org/reports/FBgn0044002 gene molecular_function ; GO:0003674 | no biological data available compound eye morphogenesis ; GO:0001745 | inferred from genetic interaction with rst cellular_component ; GO:0005575 | no biological data available "C352, Su(rst)C352" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0264407 FCG-J - http://flybase.org/reports/FBgn0264407 gene - - - "FCG-J, FC G-J" - - 27-Aug-18 DroID_v2018_08 - - - - - - "follicle cell,somatic clone" FBgn0085240 CG34211 - http://flybase.org/reports/FBgn0085240 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG34211 - CG34211 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0070030 BG00080 BG00080 http://flybase.org/reports/FBgn0070030 gene - - - BG00080 - - 27-Aug-18 DroID_v2018_08 - - - - - - "stress response defective,long lived,female limited,starvation stress response defective,temperature response defective,gravitaxis defective,sleep defective" FBgn0085292 CG34263 - http://flybase.org/reports/FBgn0085292 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG34263 IPR002350:Kazal domain CG34263 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0261739 EC4330 - http://flybase.org/reports/FBgn0261739 gene - - - EC4330 - - 27-Aug-18 DroID_v2018_08 - - - - - - female sterile FBgn0083965 CG34129 - http://flybase.org/reports/FBgn0083965 protein_coding_gene molecular_function ; GO:0003674 | no biological data available serine-type endopeptidase activity ; GO:0004252 | NOT inferred from key residues proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR001254 multicellular organism reproduction ; GO:0032504 | inferred from expression pattern extracellular space ; GO:0005615 | inferred from direct assay "CG6069, SPH192, CG34129" "IPR001254:Serine proteases, trypsin domain, IPR009003:Peptidase S1, PA clan" CG34129 27-Aug-18 DroID_v2018_08 "Drer\tmprss13a, Drer\tmprss13b, Drer\LOC100331291" - Cele\svh-1 - "Mmus\Try5, Mmus\1810009J06Rik, Mmus\Tmprss11d, Mmus\Prss57, Mmus\Prss40, Mmus\Gzmk, Mmus\Tmprss11c, Mmus\Prss45, Mmus\Tmprss11b, Mmus\Prss39, Mmus\Tmprss11e" "Hsap\PRSS45, Hsap\PRSS57, Hsap\GZMK, Hsap\TMPRSS11E, Hsap\PRSS3, Hsap\TMPRSS11D, Hsap\TMPRSS11B" viable FBgn0035933 CG13309 - http://flybase.org/reports/FBgn0035933 protein_coding_gene chitin binding ; GO:0008061 | inferred from electronic annotation with InterPro:IPR002557 molecular_function ; GO:0003674 | no biological data available chitin metabolic process ; GO:0006030 | inferred from electronic annotation with InterPro:IPR002557 multicellular organism reproduction ; GO:0032504 | inferred from expression pattern extracellular region ; GO:0005576 | inferred from electronic annotation with InterPro:IPR002557 extracellular space ; GO:0005615 | inferred from sequence model "CT32604, CG13309" IPR002557:Chitin binding domain CG13309 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0020301 fs(3)100C fs(3)100C http://flybase.org/reports/FBgn0020301 - gene - - - "fs(100C), fs(3)100C" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0030277 CG1394 - http://flybase.org/reports/FBgn0030277 protein_coding_gene - - - "bs30g07.y1, BEST:GH24085, anon-WO0140519.177, CG1394" - CG1394 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of pupal stage,some die during pupal stage" FBgn0004825 fs(2)ltoQE45 female sterile (2) ltoQE45 http://flybase.org/reports/FBgn0004825 - gene molecular_function ; GO:0003674 | no biological data available oogenesis ; GO:0048477 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available fs(2)ltoQE45 - - 27-Aug-18 DroID_v2018_08 - - - - - - female sterile FBgn0003710 tipE temperature-induced paralytic E http://flybase.org/reports/FBgn0003710 - protein_coding_gene voltage-gated sodium channel activity ; GO:0005248 | traceable author statement sodium channel regulator activity ; GO:0017080 | inferred from direct assay "cellular response to heat ; GO:0034605 | inferred from direct assay regulation of sodium ion transport ; GO:0002028 | inferred from direct assay sodium ion transport ; GO:0006814 | non-traceable author statement male courtship behavior, veined wing generated song production ; GO:0045433 | inferred from mutant phenotype" plasma membrane ; GO:0005886 | traceable author statement plasma membrane ; GO:0005886 | inferred from sequence or structural similarity inferred from direct assay integral component of plasma membrane ; GO:0005887 | inferred from direct assay "TipE, tip-E, CG1232, tipE" IPR031578:Na+ channel auxiliary subunit TipE CG1232 27-Aug-18 DroID_v2018_08 - - - - - - " embryonic stage , adult stage " " embryonic peripheral nervous system

, leg

, antenna

, antenno-maxillary complex

, adult head

, central nervous system

" "wild-type,paralytic,heat sensitive,chemical resistant,courtship behavior defective,male,recessive,neuroanatomy defective,viable,visible,lethal" "neuromuscular junction & synapse,synapse | ectopic | heat sensitive,trichogen cell" FBgn0001516 l(1)10Fj lethal (1) 10Fj http://flybase.org/reports/FBgn0001516 - gene - - - l(1)10Fj - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,polyphasic,recessive,cell lethal,germline clone" FBgn0040334 Tsp3A Tetraspanin 3A http://flybase.org/reports/FBgn0040334 protein_coding_gene molecular_function ; GO:0003674 | no biological data available positive regulation of Notch signaling pathway ; GO:0045747 | inferred from mutant phenotype border follicle cell migration ; GO:0007298 | inferred from mutant phenotype phagocytosis ; GO:0006909 | inferred from mutant phenotype integral component of membrane ; GO:0016021 | inferred from sequence model integral component of plasma membrane ; GO:0005887 | inferred from biological aspect of ancestor with PANTHER:PTN001060286 integral component of membrane ; GO:0016021 | inferred from sequence or structural similarity "CG10742, BACR7C10.6, EG:BACR7C10.6, Dm.Tsp3A, Tsp3A, tsp3A" "IPR018499:Tetraspanin/Peripherin, IPR000301:Tetraspanin, IPR008952:Tetraspanin, EC2 domain" CG10742 27-Aug-18 DroID_v2018_08 "Drer\tspan15, Drer\tspan5b, Drer\tspan14, Drer\zgc:110329, Drer\tspan33b, Drer\zgc:113223, Drer\tspan5a, Drer\LOC799194, Drer\tspan33a" - Cele\tsp-12 "Xtro\tspan33, Xtro\tspan15, Xtro\tspan5, Xtro\tspan17, Xtro\tspan14" "Mmus\Tspan17, Mmus\Tspan10, Mmus\Tspan5, Mmus\Tspan15, Mmus\Tspan14, Mmus\Rom1, Mmus\Tspan33" "Hsap\TSPAN14, Hsap\TSPAN33, Hsap\TSPAN15, Hsap\TSPAN17, Hsap\TSPAN10, Hsap\TSPAN5, Hsap\ROM1" "viable,fertile" "sensory mother cell,somatic clone,supernumerary" FBgn0030415 CG15726 - http://flybase.org/reports/FBgn0030415 protein_coding_gene - - - CG15726 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0263329 lncRNA:CR43410 - http://flybase.org/reports/FBgn0263329 non_protein_coding_gene - - - CR43410 - CR43410 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0260590 2L3081 - http://flybase.org/reports/FBgn0260590 gene - "epithelial cell migration, open tracheal system ; GO:0007427 | inferred from mutant phenotype" - 2L3081 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" "dorsal air sac primordium,somatic clone" FBgn0014903 CG14630 - http://flybase.org/reports/FBgn0014903 FBgn0029555 protein_coding_gene oxidoreductase activity ; GO:0016491 | inferred from electronic annotation with InterPro:IPR003819 oxidation-reduction process ; GO:0055114 | inferred from electronic annotation with InterPro:IPR003819 - "EG:BACR7A4.9, anon-1Eb, B, CG14630" "IPR003819:TauD/TfdA-like domain, IPR007175:RNAse P, Rpr2/Rpp21 subunit, IPR010376:Domain of unknown function DUF971" CG14630 27-Aug-18 DroID_v2018_08 "Drer\tmlhe, Drer\bbox1" Scer\AIM17 "Cele\gbh-1, Cele\gbh-2" "Xtro\tmlhe, Xtro\bbox1" "Mmus\Tmlhe, Mmus\Bbox1" "Hsap\TMLHE, Hsap\BBOX1" DRSC18166 I 2.419458636 0.134205101 0.826608037 0.346478239 -0.77077799 0.093511441 FBgn0010213 Sod2 Superoxide dismutase 2 (Mn) http://flybase.org/reports/FBgn0010213 - protein_coding_gene "metal ion binding ; GO:0046872 | inferred from electronic annotation with InterPro:IPR001189, InterPro:IPR019831, InterPro:IPR019832, InterPro:IPR019833 antioxidant activity ; GO:0016209 | non-traceable author statement superoxide dismutase activity ; GO:0004784 | inferred from sequence or structural similarity with UniProtKB:P04179" "oxidation-reduction process ; GO:0055114 | inferred from electronic annotation with InterPro:IPR001189, InterPro:IPR019831, InterPro:IPR019832, InterPro:IPR019833 heart morphogenesis ; GO:0003007 | inferred from mutant phenotype removal of superoxide radicals ; GO:0019430 | inferred from sequence or structural similarity with UniProtKB:P04179 regulation of hemocyte proliferation ; GO:0035206 | inferred from mutant phenotype regulation of mitophagy ; GO:1903146 | inferred from genetic interaction with park reactive oxygen species metabolic process ; GO:0072593 | inferred from mutant phenotype determination of adult lifespan ; GO:0008340 | inferred from mutant phenotype determination of adult lifespan ; GO:0008340 | traceable author statement regulation of metabolic process ; GO:0019222 | inferred from mutant phenotype paracrine signaling ; GO:0038001 | inferred from mutant phenotype" mitochondrial matrix ; GO:0005759 | inferred from sequence or structural similarity with UniProtKB:P04179 "Sod-2, MnSOD, Mn-SOD, Mn[2+]SOD, SOD2, CG8905, Mn SOD, mnSOD, SOD, SOD-2, Sod2, MnSODII, sod2, dSOD2, Mn-SOD2, mitSOD2, Mito SOD, dSod2" "IPR001189:Manganese/iron superoxide dismutase, IPR019831:Manganese/iron superoxide dismutase, N-terminal, IPR019832:Manganese/iron superoxide dismutase, C-terminal, IPR019833:Manganese/iron superoxide dismutase, binding site" CG8905 27-Aug-18 DroID_v2018_08 Drer\sod2 "Scer\SOD2, Scer\MRP1, Scer\RSM26" "Cele\sod-3, Cele\sod-2" Xtro\sod2 Mmus\Sod2 Hsap\SOD2 "short lived,tetracycline conditional,long lived,heat sensitive,viable,fertile,dominant,chemical sensitive,recessive,stress response defective,locomotor behavior defective,behavior defective,smell perception defective,gravitaxis defective,increased cell death,lethal,some die during immature adult stage,decreased cell number,conditional,oxidative stress response defective,bang sensitive,progressive,neuroanatomy defective" "adult heart,adult brain,lamellocyte,conditional,embryonic/larval motor neuron" DRSC07554 E -0.018967043 0.145473639 -1.958978767 0.477877685 0.162888548 0.129518469 FBgn0265914 asRNA:CR44703 - http://flybase.org/reports/FBgn0265914 non_protein_coding_gene - - - CR44703 - CR44703 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0028995 ponderosa ponderosa http://flybase.org/reports/FBgn0028995 gene molecular_function ; GO:0003674 | no biological data available dendrite morphogenesis ; GO:0048813 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available ponderosa - - 27-Aug-18 DroID_v2018_08 - - - - - - dendrite | dorsal | embryonic stage FBgn0001692 l(1)ESHS13 lethal (1) ESHS13 http://flybase.org/reports/FBgn0001692 - gene - - - l(1)ESHS13 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0004085 Ec3 Ecysone-induced RNA 3 http://flybase.org/reports/FBgn0004085 - gene - - - Ec3 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0043480 l(3)66EFf lethal (3) 66EFf http://flybase.org/reports/FBgn0043480 gene - - - l(3)66EFf - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0034183 SmydA-6 "SET and MYND domain containing, arthropod-specific, member 6" http://flybase.org/reports/FBgn0034183 protein_coding_gene histone deacetylase binding ; GO:0042826 | inferred from sequence or structural similarity with Smyd4-2 negative regulation of gene expression ; GO:0010629 | inferred from sequence or structural similarity with Smyd4-2 - "SmydA-6, CG9642" IPR001214:SET domain CG9642 27-Aug-18 DroID_v2018_08 "Drer\erlin2, Drer\smyd3, Drer\smyd4, Drer\erlin1, Drer\smyd2a, Drer\smyd2b, Drer\smyd1b, Drer\smyd1a" "Scer\SET5, Scer\SET6" "Cele\set-30, Cele\set-18, Cele\erl-1, Cele\set-10" "Xtro\smyd4, Xtro\erlin2, Xtro\erlin1, Xtro\smyd5, Xtro\smyd1" "Mmus\Smyd3, Mmus\Smyd2, Mmus\Smyd4, Mmus\Smyd1, Mmus\Zmynd15, Mmus\Erlin2, Mmus\Erlin1, Mmus\Smyd5" "Hsap\SMYD1, Hsap\SMYD3, Hsap\ERLIN1, Hsap\SMYD4, Hsap\SMYD2, Hsap\SMYD5, Hsap\ZMYND15" viable FBgn0043035 l(2)42Bi lethal (2) 42Bi http://flybase.org/reports/FBgn0043035 gene - - - l(2)42Bi - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0052512 CG32512 - http://flybase.org/reports/FBgn0052512 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "CG15447, CG1739, CG32512" IPR025423:Domain of unknown function DUF4149 CG32512 27-Aug-18 DroID_v2018_08 "Drer\si:ch211-121a2.4, Drer\tmem205" Scer\YPR098C - Xtro\tmem205 Mmus\Tmem205 Hsap\TMEM205 "partially lethal - majority die,some die during pupal stage" FBgn0264857 lncRNA:iab8 iab-8 non-coding RNA http://flybase.org/reports/FBgn0264857 non_protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "iab-8, iab-8 ncRNA, iab, msa, CG31270, mpa, CR43261, miR-iab-8, iab-8ncRNA" - CR43261 27-Aug-18 DroID_v2018_08 - - - - - - "male sterile,female sterile" FBgn0032233 dpr19 defective proboscis extension response 19 http://flybase.org/reports/FBgn0032233 protein_coding_gene molecular_function ; GO:0003674 | no biological data available synapse organization ; GO:0050808 | inferred from expression pattern sensory perception of chemical stimulus ; GO:0007606 | inferred from sequence or structural similarity with dpr1 integral component of plasma membrane ; GO:0005887 | inferred from sequence model "CG13140, Dpr-19, BcDNA:LP09705, dpr19, Dpr19" "IPR003598:Immunoglobulin subtype 2, IPR003599:Immunoglobulin subtype, IPR007110:Immunoglobulin-like domain, IPR013106:Immunoglobulin V-set domain, IPR013783:Immunoglobulin-like fold" CG13140 27-Aug-18 DroID_v2018_08 "Drer\ush2a, Drer\ncam1b, Drer\LOC100333196, Drer\kirrel3a, Drer\igsf9a, Drer\sdk1a, Drer\sdk1b, Drer\si:ch211-264f5.6, Drer\lrit3b, Drer\kirrela, Drer\igsf9bb, Drer\LOC101885444, Drer\kirrel3b, Drer\dscama, Drer\si:dkey-65b12.12, Drer\paplna, Drer\itgb4, Drer\kirrel3l, Drer\lrit3a, Drer\lrit1b, Drer\kirrelb, Drer\si:ch1073-459j12.1, Drer\lrit1a" - Cele\zig-8 "Xtro\nfasc, Xtro\kirrel2, Xtro\igsf9b, Xtro\obsl1, Xtro\lrit3, Xtro\papln" "Mmus\Amica1, Mmus\Lrit1, Mmus\Lrit3, Mmus\Kirrel3, Mmus\Kirrel, Mmus\Ptprq, Mmus\Sdk1, Mmus\Kirrel2, Mmus\Papln, Mmus\Igsf9b" "Hsap\USH2A, Hsap\KIRREL3, Hsap\SDK1, Hsap\CADM3, Hsap\LRIT3, Hsap\KIRREL2, Hsap\CADM4, Hsap\KIRREL, Hsap\LRIT1, Hsap\CADM1, Hsap\PAPLN, Hsap\IGSF9B, Hsap\CADM2" viable FBgn0050154 CG30154 - http://flybase.org/reports/FBgn0050154 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG30154 - CG30154 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0039405 PIG-P Phosphatidylinositol glycan anchor biosynthesis class P http://flybase.org/reports/FBgn0039405 protein_coding_gene phosphatidylinositol N-acetylglucosaminyltransferase activity ; GO:0017176 | contributes_to inferred from biological aspect of ancestor with PANTHER:PTN000497247 UDP-glycosyltransferase activity ; GO:0008194 | contributes_to inferred from sequence or structural similarity with SGD:S000002845 GPI anchor biosynthetic process ; GO:0006506 | inferred from sequence or structural similarity with SGD:S000002845 endoplasmic reticulum ; GO:0005783 | inferred from sequence or structural similarity with SGD:S000002845 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex ; GO:0000506 | inferred from biological aspect of ancestor with PANTHER:PTN001094394 "BcDNA:GM30016, Dromel_CG14550_FBtr0084974_mORF, PIG-P, CG14550" IPR013717:PIG-P CG14550 27-Aug-18 DroID_v2018_08 "Drer\pigp, Drer\noa1" Scer\GPI19 Cele\Y48E1B.2 Xtro\pigp "Mmus\Noa1, Mmus\Gm6880, Mmus\Lage3, Mmus\Pigp, Mmus\Gm6890, Mmus\Ctag2" "Hsap\CTAG2, Hsap\LAGE3, Hsap\NOA1, Hsap\PIGP" viable FBgn0085697 CG41568 - http://flybase.org/reports/FBgn0085697 protein_coding_gene - - - CG41568 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0262331 mir-999 mir-999 stem loop http://flybase.org/reports/FBgn0262331 miRNA_gene - - - "dme-mir-999, miR-999, mir-999, CR43038, miR999, dme-miR-999" - CR43038 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,visible,lethal - all die before end of P-stage,some die during pharate adult stage" wing FBgn0004040 yea6 yeast 6 http://flybase.org/reports/FBgn0004040 - gene - - - yea6 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0065420 l(2)SH1525 lethal (2) SH1525 http://flybase.org/reports/FBgn0065420 gene - - - "l(2)SH1525, l(2)SH2 1525" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0051343 CG31343 - http://flybase.org/reports/FBgn0051343 protein_coding_gene metalloaminopeptidase activity ; GO:0070006 | inferred from biological aspect of ancestor with PANTHER:PTN000164249 peptide binding ; GO:0042277 | inferred from biological aspect of ancestor with PANTHER:PTN000164249 zinc ion binding ; GO:0008270 | inferred from biological aspect of ancestor with PANTHER:PTN000164249 peptide catabolic process ; GO:0043171 | inferred from biological aspect of ancestor with PANTHER:PTN000164249 proteolysis ; GO:0006508 | inferred from biological aspect of ancestor with PANTHER:PTN000164249 cytoplasm ; GO:0005737 | inferred from biological aspect of ancestor with PANTHER:PTN000164249 "CG5839, BEST:GH20248, anon-WO0140519.86, CG31343" "IPR024571:ERAP1-like C-terminal domain, IPR001930:Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase, IPR014782:Peptidase M1, membrane alanine aminopeptidase, N-terminal, IPR034016:Aminopeptidase N-type" CG31343 27-Aug-18 DroID_v2018_08 "Drer\lnpep, Drer\anpepb, Drer\erap1b, Drer\si:ch211-106j24.1, Drer\si:ch211-149p5.1, Drer\enpep, Drer\erap1a, Drer\npepps, Drer\anpepa, Drer\si:ch211-276a23.5, Drer\si:ch211-198g19.1, Drer\erap2" "Scer\AAP1, Scer\TMA108, Scer\APE2" "Cele\T12E12.6, Cele\F49B2.6, Cele\VB0395L.1, Cele\mnp-1, Cele\AC3.5, Cele\Y53F4B.20, Cele\T16G12.1, Cele\Y67D8C.9, Cele\Y42A5A.1, Cele\R03G8.6, Cele\pam-1, Cele\R03G8.4, Cele\T07F10.1" "Xtro\lnpep, Xtro\anpep, Xtro\erap1, Xtro\lvrn, Xtro\npepps, Xtro\enpep" "Mmus\Lnpep, Mmus\Npepps, Mmus\Enpep, Mmus\Lvrn, Mmus\Trhde, Mmus\Erap1, Mmus\Anpep" "Hsap\NPEPPS, Hsap\LVRN, Hsap\LNPEP, Hsap\ANPEP, Hsap\TRHDE, Hsap\ENPEP, Hsap\ERAP1, Hsap\ERAP2" viable FBgn0032732 CG15168 - http://flybase.org/reports/FBgn0032732 protein_coding_gene inorganic cation transmembrane transporter activity ; GO:0022890 | inferred from biological aspect of ancestor with PANTHER:PTN000475936 cation transmembrane transport ; GO:0098655 | inferred from biological aspect of ancestor with PANTHER:PTN000475936 plasma membrane ; GO:0005886 | inferred from biological aspect of ancestor with PANTHER:PTN000475936 early endosome ; GO:0005769 | inferred from biological aspect of ancestor with PANTHER:PTN000475936 Golgi apparatus ; GO:0005794 | inferred from biological aspect of ancestor with PANTHER:PTN000475936 ER membrane protein complex ; GO:0072546 | inferred from biological aspect of ancestor with PANTHER:PTN000475936 "BcDNA:RE09053, CG15168" IPR018937:Magnesium transporter CG15168 27-Aug-18 DroID_v2018_08 Drer\mmgt1 - Cele\emc-5 Xtro\mmgt1 "Mmus\Mmgt1, Mmus\Mmgt2" Hsap\MMGT1 "partially lethal - majority die,some die during pupal stage" FBgn0050043 CG30043 - http://flybase.org/reports/FBgn0050043 protein_coding_gene - - - "CG13161, CG30043" IPR007484:Peptidase M28 CG30043 27-Aug-18 DroID_v2018_08 Drer\LOC100330918 "Scer\PFF1, Scer\APE3, Scer\YDR415C, Scer\VPS70" "Cele\C44B7.11, Cele\B0495.7" Xtro\ermp1 Mmus\Ermp1 Hsap\ERMP1 viable FBgn0260313 GSd445 - http://flybase.org/reports/FBgn0260313 gene - - - GSd445 - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0031204 CG9562 - http://flybase.org/reports/FBgn0031204 protein_coding_gene - - - "tartan/capricious-like, CT16794, CG9562" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0053727 snmRNA:430a snmRNA:430:CR33727 http://flybase.org/reports/FBgn0053727 non_protein_coding_gene - - - "CR33727, snmRNA:430:CR33727" - CR33727 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0015851 anon-10Cd anon-10Cd http://flybase.org/reports/FBgn0015851 - gene - - - anon-10Cd - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0065367 l(2)SH1715 lethal (2) SH1715 http://flybase.org/reports/FBgn0065367 gene - - - "l(2)SH1715, l(2)SH2 1715" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0026353 Su(SuRaf1)2 Su(SuRaf1)2 http://flybase.org/reports/FBgn0026353 - gene - - - "Su[Su(Raf)1]2, Su(SuRaf1)2" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0029522 CG13373 - http://flybase.org/reports/FBgn0029522 protein_coding_gene - - - CG13373 IPR022773:Siva CG13373 27-Aug-18 DroID_v2018_08 Drer\siva1 - - Xtro\siva1 Mmus\Siva1 Hsap\SIVA1 "viable,fertile" FBgn0001007 fs(3)6m45 female sterile (3) 6m45 http://flybase.org/reports/FBgn0001007 - gene - - - fs(3)6m45 - - 27-Aug-18 DroID_v2018_08 - - - - - - female sterile "oocyte,ovary" FBgn0033753 Cyp301a1 Cyp301a1 http://flybase.org/reports/FBgn0033753 protein_coding_gene "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen ; GO:0016705 | inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401 heme binding ; GO:0020037 | inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401 iron ion binding ; GO:0005506 | inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401" "oxidation-reduction process ; GO:0055114 | inferred from electronic annotation with InterPro:IPR001128, InterPro:IPR002401 tergite morphogenesis ; GO:0007490 | inferred from mutant phenotype" - "301a1, CG8587, Cyp301a1, Cyp301A1" "IPR001128:Cytochrome P450, IPR002401:Cytochrome P450, E-class, group I" CG8587 27-Aug-18 DroID_v2018_08 "Drer\cyp27a1.2, Drer\zgc:136333, Drer\cyp11a2, Drer\cyp27a1.4, Drer\cyp11c1, Drer\cyp27a7, Drer\cyp27b1, Drer\si:dkey-91i10.3, Drer\si:ch211-113j14.1, Drer\cyp24a1, Drer\cyp27c1" Scer\DIT2 "Cele\cyp-37B1, Cele\cyp-44A1" "Xtro\cyp27b1, Xtro\LOC100145331, Xtro\cyp27c1, Xtro\cyp11a1, Xtro\cyp24a1, Xtro\cyp27a1" "Mmus\Cyp24a1, Mmus\Cyp27a1, Mmus\Cyp11b1, Mmus\Cyp27b1, Mmus\Cyp11a1, Mmus\Cyp11b2" "Hsap\CYP24A1, Hsap\CYP27C1, Hsap\CYP11B1, Hsap\CYP11A1, Hsap\CYP27A1, Hsap\CYP11B2, Hsap\CYP27B1" "viable,fertile,visible,recessive,partially lethal - majority live,body color defective" "tergite,adult cuticle,mesothoracic tergum" FBgn0005687 pom pomegranate http://flybase.org/reports/FBgn0005687 - gene molecular_function ; GO:0003674 | no biological data available compound eye development ; GO:0048749 | inferred from mutant phenotype cellular_component ; GO:0005575 | no biological data available pom - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,recessive" "eye,ommatidium" FBgn0043571 SK2-3 SK2-3 http://flybase.org/reports/FBgn0043571 gene - - - SK2-3 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0267074 asRNA:CR45518 - http://flybase.org/reports/FBgn0267074 non_protein_coding_gene - - - CR45518 - CR45518 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0038373 CG4546 - http://flybase.org/reports/FBgn0038373 protein_coding_gene "kinase activity ; GO:0016301 | inferred from electronic annotation with InterPro:IPR022413, InterPro:IPR022414, InterPro:IPR022415" multicellular organism reproduction ; GO:0032504 | inferred from expression pattern extracellular space ; GO:0005615 | inferred from direct assay CG4546 "IPR000749:ATP:guanido phosphotransferase, IPR014746:Glutamine synthetase/guanido kinase, catalytic domain, IPR022413:ATP:guanido phosphotransferase, N-terminal, IPR022414:ATP:guanido phosphotransferase, catalytic domain, IPR022415:ATP:guanido phosphotransferase active site" CG4546 27-Aug-18 DroID_v2018_08 "Drer\ckmb, Drer\ckba, Drer\ckmt1, Drer\ckmt2b, Drer\ckmt2a, Drer\ckma, Drer\ckbb" - "Cele\ZC434.8, Cele\F32B5.1, Cele\W10C8.5, Cele\argk-1, Cele\F46H5.3, Cele\F11G11.13" "Xtro\ckm, Xtro\ckmt1b, Xtro\ckb" "Mmus\Ckm, Mmus\Ckmt2, Mmus\Mycbp, Mmus\Ckb, Mmus\Ckmt1" "Hsap\MYCBP, Hsap\CKM, Hsap\CKMT1A, Hsap\CKMT2, Hsap\CKMT1B, Hsap\CKB" viable FBgn0013454 fs(2)neo11 fs(2)neo11 http://flybase.org/reports/FBgn0013454 - gene - - - fs(2)neo11 - - 27-Aug-18 DroID_v2018_08 - - - - - - "female sterile,fertile" FBgn0082189 l(3)S012606 lethal (3) S012606 http://flybase.org/reports/FBgn0082189 gene - - - l(3)S012606 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0264881 CG44072 - http://flybase.org/reports/FBgn0264881 protein_coding_gene - - - CG44072 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0266850 lncRNA:CR45311 - http://flybase.org/reports/FBgn0266850 non_protein_coding_gene - - - CR45311 - CR45311 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0031646 snsl - http://flybase.org/reports/FBgn0031646 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG2837 - CG2837 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0063408 l(3)3450-O lethal (3) 3450-O http://flybase.org/reports/FBgn0063408 gene - - - l(3)3450-O - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of embryonic stage,recessive,some die during embryonic stage" FBgn0028468 rtet tetracycline resistance http://flybase.org/reports/FBgn0028468 protein_coding_gene tetracycline transporter activity ; GO:0008493 | inferred from biological aspect of ancestor with PANTHER:PTN001921260 tetracycline transport ; GO:0015904 | inferred from biological aspect of ancestor with PANTHER:PTN001921260 transmembrane transport ; GO:0055085 | inferred from biological aspect of ancestor with PANTHER:PTN001921112 oogenesis ; GO:0048477 | inferred from mutant phenotype "integral component of membrane ; GO:0016021 | inferred from electronic annotation with InterPro:IPR005829, InterPro:IPR011701 brush border membrane ; GO:0031526 | inferred from biological aspect of ancestor with PANTHER:PTN001921260" "CG5760, Drtet, l(3)07086, BcDNA:LD28419, anon-WO0119857.1, rtet" "IPR005829:Sugar transporter, conserved site, IPR011701:Major facilitator superfamily, IPR020846:Major facilitator superfamily domain" CG5760 27-Aug-18 DroID_v2018_08 Drer\mfsd10 "Scer\SGE1, Scer\YCR023C" "Cele\Y71G12B.25, Cele\F10D7.2, Cele\unc-17" Xtro\mfsd10 Mmus\Mfsd10 Hsap\MFSD10 "viable,fertile,lethal,recessive,female sterile,lethal - all die before end of larval stage,some die during larval stage" "ovariole,germline clone,egg" FBgn0267037 asRNA:CR45481 - http://flybase.org/reports/FBgn0267037 non_protein_coding_gene - - - CR45481 - CR45481 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0260330 GSd482 - http://flybase.org/reports/FBgn0260330 gene - - - GSd482 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,neuroanatomy defective" "ventral nerve cord,intersegmental nerve,segmental nerve" FBgn0266916 Cenp-C Centromeric protein-C http://flybase.org/reports/FBgn0266916 protein_coding_gene - "protein localization to kinetochore ; GO:0034501 | inferred from mutant phenotype chromosome segregation ; GO:0007059 | inferred from mutant phenotype neurogenesis ; GO:0022008 | inferred from mutant phenotype protein localization to chromosome, centromeric region ; GO:0071459 | inferred from mutant phenotype mitotic metaphase plate congression ; GO:0007080 | inferred from mutant phenotype regulation of centromere complex assembly ; GO:0090230 | inferred from direct assay female meiosis chromosome segregation ; GO:0016321 | inferred from mutant phenotype regulation of centromere complex assembly ; GO:0090230 | inferred from mutant phenotype regulation of stem cell differentiation ; GO:2000736 | inferred from mutant phenotype kinetochore assembly ; GO:0051382 | inferred from mutant phenotype" "kinetochore ; GO:0000776 | inferred from direct assay kinetochore ; GO:0000776 | colocalizes_with inferred from direct assay chromosome, centromeric region ; GO:0000775 | inferred from direct assay condensed nuclear chromosome, centromeric region ; GO:0000780 | inferred from direct assay chromosome, centromeric region ; GO:0000775 |" "cenp-C, Cenp-C, CG31258, CenpC, CENP-C, l(3)85Aa, L1, CG11745, CG11746, CLD1, l(3)SH157, l(2)SH3 157" - CG31258 27-Aug-18 DroID_v2018_08 Drer\krtcap2 - Cele\set-2 - Mmus\Krtcap2 Hsap\KRTCAP2 DRSC14371 E -1.229021924 -0.012567605 -0.04471976 -1.960457999 -1.057280315 1.08633189 FBgn0037874 Tctp Translationally controlled tumor protein http://flybase.org/reports/FBgn0037874 protein_coding_gene calcium ion binding ; GO:0005509 | inferred from sequence or structural similarity with UniProtKB:P13693 calcium ion binding ; GO:0005509 | inferred from biological aspect of ancestor with PANTHER:PTN000241815 guanyl-nucleotide exchange factor activity ; GO:0005085 | inferred from direct assay Ras guanyl-nucleotide exchange factor activity ; GO:0005088 | NOT inferred from direct assay microtubule binding ; GO:0008017 | inferred from biological aspect of ancestor with PANTHER:PTN000241815 positive regulation of multicellular organism growth ; GO:0040018 | inferred from mutant phenotype cellular response to gamma radiation ; GO:0071480 | inferred from mutant phenotype double-strand break repair ; GO:0006302 | inferred from mutant phenotype positive regulation of histone phosphorylation ; GO:0033129 | inferred from direct assay positive regulation of cell size ; GO:0045793 | inferred from mutant phenotype mitotic G2 DNA damage checkpoint ; GO:0007095 | inferred from mutant phenotype intra-S DNA damage checkpoint ; GO:0031573 | inferred from mutant phenotype regulation of stem cell differentiation ; GO:2000736 | inferred from mutant phenotype nucleus ; GO:0005634 | inferred from direct assay tubulin complex ; GO:0045298 | colocalizes_with inferred from sequence or structural similarity with UniProtKB:P13693 polytene chromosome ; GO:0005700 | inferred from direct assay plasma membrane ; GO:0005886 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from biological aspect of ancestor with PANTHER:PTN000241815 "dTCTP, CG4800, TCTP, Tctp" "IPR018103:Translationally controlled tumour protein, conserved site, IPR018105:Translationally controlled tumour protein, IPR011057:Mss4-like, IPR034737:Translationally controlled tumor protein (TCTP) domain" CG4800 27-Aug-18 DroID_v2018_08 Drer\tpt1 Scer\TMA19 Cele\tct-1 Xtro\tpt1 Mmus\Tpt1 "Hsap\FLJ44635, Hsap\TPT1" "viable,mitotic cell cycle defective,maternal effect,lethal,recessive,small body,radiation sensitive,DNA repair defective,visible,decreased cell size,decreased cell number,lethal - all die before end of larval stage,some die during third instar larval stage,somatic clone,lethal - all die before end of first instar larval stage,some die during first instar larval stage,partially lethal - majority die,some die during pupal stage" "eye,wing,1st posterior cell,imaginal disc,somatic clone,trichogen cell,mesothoracic tergum" FBgn0267585 lncRNA:CR45923 - http://flybase.org/reports/FBgn0267585 non_protein_coding_gene - - - "CR45923, CR44101, CG17478, CG40280" - CR45923 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0026250 eIF1A eukaryotic translation initiation factor 1A http://flybase.org/reports/FBgn0026250 "FBgn0025531, FBgn0025959, FBgn0038594, FBgn0062638" protein_coding_gene "translation initiation factor activity ; GO:0003743 | inferred from electronic annotation with InterPro:IPR001253, InterPro:IPR006196, InterPro:IPR018104 translation initiation factor activity ; GO:0003743 | inferred from sequence or structural similarity" "translational initiation ; GO:0006413 | inferred from electronic annotation with InterPro:IPR001253, InterPro:IPR006196, InterPro:IPR018104 translational initiation ; GO:0006413 | inferred from sequence or structural similarity phagocytosis ; GO:0006909 | inferred from mutant phenotype translation ; GO:0006412 | inferred from sequence or structural similarity smoothened signaling pathway ; GO:0007224 | inferred from genetic interaction with smo" nucleoplasm ; GO:0005654 | inferred from direct assay cytosol ; GO:0005829 | inferred from sequence or structural similarity cytosol ; GO:0005829 | inferred from direct assay eukaryotic 43S preinitiation complex ; GO:0016282 | inferred from sequence or structural similarity "eIF1A, group I, Group I, CG8053, D-eIF1A, eIF-4c, D-eIF4c, anon-EST:Liang-2.3, clone 2.3, EP(3)0935, EP935, anon-EST:Posey4, eIF-1A, lincRNA.S7087" "IPR018104:Translation initiation factor 1A (eIF-1A), conserved site, IPR001253:Translation initiation factor 1A (eIF-1A), IPR006196:RNA-binding domain, S1, IF1 type, IPR012340:Nucleic acid-binding, OB-fold" CG8053 27-Aug-18 DroID_v2018_08 "Drer\eif1axb, Drer\eif1axa" Scer\TIF11 Cele\eif-1.A Xtro\eif1ax "Mmus\Eif1a, Mmus\Gm2016, Mmus\Gm2022, Mmus\Gm8300, Mmus\Gm2046, Mmus\Gm21936, Mmus\Eif1ax, Mmus\Gm5662, Mmus\Gm21319, Mmus\Gm4027, Mmus\BB287469" "Hsap\LOC107984923, Hsap\EIF1AX, Hsap\EIF1AY" "viable,fertile,lethal,recessive,cell lethalcell lethal,somatic clone" DRSC16937 I -3.735674488 -1.796659258 -0.15675353 -1.300122881 0.70594744 1.456308064 FBgn0058142 CG40142 - http://flybase.org/reports/FBgn0058142 protein_coding_gene - - - CG40142 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0014277 l(2)k16904 lethal (2) k16904 http://flybase.org/reports/FBgn0014277 - gene - - - "l(2)169/4, l(2)k16904" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0003622 Su(var)2-147 Suppressor of variegation 2-147 http://flybase.org/reports/FBgn0003622 - gene - - - Su(var)2-147 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0034136 DAT Dopamine transporter http://flybase.org/reports/FBgn0034136 protein_coding_gene cocaine binding ; GO:0019811 | inferred from direct assay dopamine transmembrane transporter activity ; GO:0005329 | inferred from direct assay dopamine:sodium symporter activity ; GO:0005330 | inferred from biological aspect of ancestor with PANTHER:PTN000746001 circadian sleep/wake cycle ; GO:0042745 | inferred from direct assay sleep ; GO:0030431 | inferred from mutant phenotype regulation of presynaptic cytosolic calcium ion concentration ; GO:0099509 | inferred from mutant phenotype dopamine transport ; GO:0015872 | inferred from direct assay response to odorant ; GO:1990834 | inferred from mutant phenotype dopamine uptake involved in synaptic transmission ; GO:0051583 | inferred from biological aspect of ancestor with PANTHER:PTN000746001 circadian sleep/wake cycle ; GO:0042745 | inferred from mutant phenotype adult locomotory behavior ; GO:0008344 | inferred from mutant phenotype integral component of plasma membrane ; GO:0005887 | inferred from direct assay integral component of plasma membrane ; GO:0005887 | inferred from sequence model integral component of plasma membrane ; GO:0005887 | inferred from biological aspect of ancestor with PANTHER:PTN000177662 neuron projection ; GO:0043005 | inferred from biological aspect of ancestor with PANTHER:PTN000746001 "CG8380, fmn, DAT, dDAT, DmDAT, fumin, dat" IPR000175:Sodium:neurotransmitter symporter CG8380 27-Aug-18 DroID_v2018_08 "Drer\slc6a13, Drer\slc6a11a, Drer\si:ch211-132b12.6, Drer\slc6a16a, Drer\slc6a2, Drer\slc6a15, Drer\slc6a14, Drer\zgc:158225, Drer\slc6a6a, Drer\slc6a16b, Drer\slc6a18, Drer\slc6a5, Drer\slc6a19a.1, Drer\slc6a13, Drer\slc6a1l, Drer\si:ch211-117c9.5, Drer\slc6a13l, Drer\slc6a19a.2, Drer\si:ch211-132b12.2, Drer\slc6a4b, Drer\slc6a9, Drer\slc6a1b, Drer\slc6a8, Drer\slc6a19b, Drer\slc6a4a, Drer\slc6a6b, Drer\slc6a17, Drer\slc6a1a, Drer\si:ch211-132b12.1" - "Cele\dat-1, Cele\snf-11, Cele\snf-3, Cele\snf-6, Cele\mod-5" "Xtro\slc6a8, Xtro\slc6a12, Xtro\slc6a2, Xtro\slc6a6, Xtro\slc6a4, Xtro\slc6a16, Xtro\slc6a17, Xtro\slc6a13, Xtro\slc6a5, Xtro\slc6a15, Xtro\LOC100127682, Xtro\slc6a1, Xtro\slc6a3, Xtro\slc6a19, Xtro\slc6a7, Xtro\slc6a14.2, Xtro\slc6a9" "Mmus\Slc6a9, Mmus\Slc6a17, Mmus\Slc6a12, Mmus\Slc6a3, Mmus\Slc6a5, Mmus\Slc6a14, Mmus\Slc6a16, Mmus\Slc6a2, Mmus\Slc6a15, Mmus\Slc6a13, Mmus\Slc6a4, Mmus\Slc6a19, Mmus\Slc6a8, Mmus\Slc6a1, Mmus\Slc6a21, Mmus\Slc6a11, Mmus\Slc6a7, Mmus\Slc6a6, Mmus\Slc6a20a, Mmus\Slc6a20b, Mmus\Slc6a18" "Hsap\SLC6A13, Hsap\SLC6A11, Hsap\SLC6A2, Hsap\SLC6A3, Hsap\SLC6A19, Hsap\SLC6A6, Hsap\SLC6A20, Hsap\SLC6A9, Hsap\SLC6A8, Hsap\SLC6A7, Hsap\SLC6A17, Hsap\SLC6A12, Hsap\SLC6A18, Hsap\SLC6A1, Hsap\SLC6A4, Hsap\SLC6A5, Hsap\SLC6A15, Hsap\SLC6A16, Hsap\SLC6A14" "behavior defective,hyperactive,chemical conditional,locomotor behavior defective,circadian rhythm defective,viable,fertile,sleep defective,visible" mesothoracic tergum FBgn0016072 su(w[a])::tra su(w[a])::tra http://flybase.org/reports/FBgn0016072 - engineered_fusion_gene - - - su(w[a])::tra - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0046776 CR14033 - http://flybase.org/reports/FBgn0046776 pseudogene_attribute - - - "BcDNA:LD26231, BcDNA:LD26673, CR14033, CG14033" - CR14033 27-Aug-18 DroID_v2018_08 - - - - - - viable DRSC02358 E 1.184358107 0.841403925 1.551278363 3.273890028 0.536744075 0.112569003 FBgn0259657 B2037 - http://flybase.org/reports/FBgn0259657 gene - - - B2037 - - 27-Aug-18 DroID_v2018_08 - - - - - - visible "leg,proximal,scutellum" FBgn0036164 CG7543 - http://flybase.org/reports/FBgn0036164 protein_coding_gene - - - CG7543 - - 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0065285 l(2)SH2022 lethal (2) SH2022 http://flybase.org/reports/FBgn0065285 gene - - - "l(2)SH2022, l(2)SH2 2022" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0029074 l(1)G0145 lethal (1) G0145 http://flybase.org/reports/FBgn0029074 gene - - - l(1)G0145 - - 27-Aug-18 DroID_v2018_08 - - - - - - "partially lethal - majority die,recessive,lethal - all die before end of larval stage,some die during larval stage" FBgn0022893 Df31 Decondensation factor 31 http://flybase.org/reports/FBgn0022893 "FBgn0015041, FBgn0022155, FBgn0022348, FBgn0025987, FBgn0026586, FBgn0027759, FBgn0045899, FBtr0085919, FBtr0085920, FBpp0085274" protein_coding_gene histone binding ; GO:0042393 | inferred from direct assay nucleosome assembly ; GO:0006334 | inferred from direct assay chromatin organization ; GO:0006325 | inferred from mutant phenotype nucleus ; GO:0005634 | inferred from direct assay plasma membrane ; GO:0005886 | inferred from direct assay chromatin ; GO:0000785 | inferred from direct assay polytene chromosome ; GO:0005700 | colocalizes_with inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay "anon-EST:Posey126, CG2207, anon1A4, DF 31, LD04967, clone 1.46, DF31, l(2)k05815, anon-EST:fe1A4, BEST:LD04967, anon-EST:Liang-1.46, anon-WO0153538.53, Df31" - CG2207 27-Aug-18 DroID_v2018_08 - - - - - - "viable,lethal,recessive,long lived,wild-type,partially lethal - majority die" chromatin FBgn0260599 2L2718 - http://flybase.org/reports/FBgn0260599 gene - "epithelial cell migration, open tracheal system ; GO:0007427 | inferred from mutant phenotype" - 2L2718 - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" "dorsal air sac primordium,somatic clone" FBgn0267961 lncRNA:CR46241 - http://flybase.org/reports/FBgn0267961 non_protein_coding_gene - - - "CR46241, lincRNA.522" - CR46241 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0027615 CG6404 - http://flybase.org/reports/FBgn0027615 - protein_coding_gene - protein insertion into membrane ; GO:0051205 | inferred from electronic annotation with InterPro:IPR001708 respiratory chain complex IV assembly ; GO:0008535 | inferred from sequence or structural similarity with UniProtKB:Q15070 integral component of membrane ; GO:0016021 | inferred from electronic annotation with InterPro:IPR001708 mitochondrial envelope ; GO:0005740 | inferred from sequence or structural similarity with UniProtKB:Q15070 "BcDNA:GH02220, CG6404, OXA1" "IPR001708:Membrane insertase OXA1/ALB3/YidC, IPR028055:Membrane insertase YidC/Oxa1, C-terminal" CG6404 27-Aug-18 DroID_v2018_08 "Drer\oxa1l, Drer\cox18" "Scer\OXA1, Scer\COX18" "Cele\Y55F3AR.1, Cele\oxa-1" "Xtro\oxa1l, Xtro\cox18" "Mmus\Cox18, Mmus\Oxa1l" "Hsap\COX18, Hsap\OXA1L" DRSC09672 K 0.320060997 -0.359578719 -0.163800958 0.243142942 0.603791233 1.713725377 FBgn0011748 anon-M-SAR anonymous M/SAR sequence http://flybase.org/reports/FBgn0011748 - repeat_region - - - "centromere; lamin. centromeric beta-heterochromatin sequence, anon-M/SAR, anon-M-SAR" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0037402 Vha14-2 Vacuolar H[+] ATPase 14kD subunit 2 http://flybase.org/reports/FBgn0037402 protein_coding_gene "proton-transporting ATPase activity, rotational mechanism ; GO:0046961 | inferred from electronic annotation with InterPro:IPR005772 ATPase coupled ion transmembrane transporter activity ; GO:0042625 | inferred from biological aspect of ancestor with PANTHER:PTN001015339" ATP hydrolysis coupled proton transport ; GO:0015991 | inferred from electronic annotation with InterPro:IPR005772 ATP hydrolysis coupled proton transport ; GO:0015991 | inferred by curator from GO:0033176 "proton-transporting V-type ATPase, V1 domain ; GO:0033180 | inferred from electronic annotation with InterPro:IPR005772 proton-transporting V-type ATPase complex ; GO:0033176 | inferred from sequence or structural similarity with Vha14-1 membrane ; GO:0016020 | inferred from biological aspect of ancestor with PANTHER:PTN001015339" "vha14-2, CG1076, Vha14-2" "IPR005772:ATPase, V1 complex, subunit F, eukaryotic, IPR008218:ATPase, V1 complex, subunit F" CG1076 27-Aug-18 DroID_v2018_08 Drer\atp6v1f Scer\VMA7 Cele\vha-9 Xtro\atp6v1f Mmus\Atp6v1f Hsap\ATP6V1F viable FBgn0039299 CG11854 - http://flybase.org/reports/FBgn0039299 protein_coding_gene - - extracellular space ; GO:0005615 | inferred from sequence or structural similarity with to CG11854 IPR010562:Haemolymph juvenile hormone binding CG11854 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0065736 l(2)SH0541 lethal (2) SH0541 http://flybase.org/reports/FBgn0065736 gene - - - "l(2)SH0541, l(2)SH2 0541" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0004994 Cor Corroded eye http://flybase.org/reports/FBgn0004994 - gene - - - Cor - - 27-Aug-18 DroID_v2018_08 - - - - - - "visible,dominant" eye FBgn0053669 CG33669 - http://flybase.org/reports/FBgn0053669 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available "bs03a05.y1, NEST:bs03a05, CG33669" - CG33669 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0285970 CG32500 TO42 http://flybase.org/reports/FBgn0029115 gene iron-sulfur cluster binding ; GO:0051536 | inferred from electronic annotation with InterPro:IPR001075 iron ion binding ; GO:0005506 | inferred from electronic annotation with InterPro:IPR001075 "iron-sulfur cluster assembly ; GO:0016226 | inferred from electronic annotation with InterPro:IPR001075, InterPro:IPR017065" - "clot#9754, TO42" "IPR000629:ATP-dependent RNA helicase DEAD-box, conserved site, IPR014824:Scaffold protein Nfu/NifU, N-terminal, IPR001075:NIF system FeS cluster assembly, NifU, C-terminal, IPR017065:NFU1 iron-sulfur cluster scaffold homologue" - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0011215 cash cashews http://flybase.org/reports/FBgn0011215 - gene - spermatid development ; GO:0007286 | inferred from mutant phenotype - "cas, cash" - - 27-Aug-18 DroID_v2018_08 - - - - - - "male sterile,recessive" FBgn0044083 E(rst)H186 E(rst)H186 http://flybase.org/reports/FBgn0044083 gene molecular_function ; GO:0003674 | no biological data available compound eye morphogenesis ; GO:0001745 | inferred from genetic interaction with rst cellular_component ; GO:0005575 | no biological data available "H186, E(rst)H186" - - 27-Aug-18 DroID_v2018_08 - - - - - - viable eye FBgn0040737 Tango8 Transport and Golgi organization 8 http://flybase.org/reports/FBgn0040737 protein_coding_gene molecular_function ; GO:0003674 | no biological data available Golgi organization ; GO:0007030 | inferred from mutant phenotype protein secretion ; GO:0009306 | inferred from mutant phenotype endoplasmic reticulum ; GO:0005783 | inferred from direct assay "CG14503, TANGO8, Tango8" - CG14503 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0267612 lncRNA:CR45950 - http://flybase.org/reports/FBgn0267612 non_protein_coding_gene - - - CR45950 - CR45950 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0039031 Gbp3 Growth-blocking peptide 3 http://flybase.org/reports/FBgn0039031 protein_coding_gene cytokine activity ; GO:0005125 | inferred from sequence or structural similarity with Gbp1 signal transduction ; GO:0007165 | inferred from sequence or structural similarity with Gbp1 cellular_component ; GO:0005575 | no biological data available "BcDNA:RH17470, CG17244, Gbp3, GBP3" - CG17244 27-Aug-18 DroID_v2018_08 - - - - - - viable DRSC15206 K 0.463009169 -0.325969033 1.052178418 -0.225560437 -1.608280657 -0.859813274 FBgn0263476 snoRNA:CG32479-b - http://flybase.org/reports/FBgn0263476 snoRNA_gene - - - snoRNA:CG32479-b - CR43591 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0033461 CG12923 - http://flybase.org/reports/FBgn0033461 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG12923 IPR031732:Protein of unknown function DUF4729 CG12923 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0016842 l(1)N15 lethal (1) N15 http://flybase.org/reports/FBgn0016842 - gene - - - "l(1)N15, N15" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0038879 CG17298 - http://flybase.org/reports/FBgn0038879 protein_coding_gene - - - "CT35916, BcDNA:RH37844, CG17298" - CG17298 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0265597 rad radish http://flybase.org/reports/FBgn0265597 protein_coding_gene zinc ion binding ; GO:0008270 | inferred from electronic annotation with InterPro:IPR001781 GTPase activator activity ; GO:0005096 | inferred from sequence or structural similarity with RapGAP1 regulation of small GTPase mediated signal transduction ; GO:0051056 | inferred from electronic annotation with InterPro:IPR000331 anesthesia-resistant memory ; GO:0007615 | inferred from direct assay olfactory learning ; GO:0008355 | traceable author statement anesthesia-resistant memory ; GO:0007615 | traceable author statement regulation of heart contraction ; GO:0008016 | inferred from mutant phenotype neuronal cell body ; GO:0043025 | inferred from direct assay nucleus ; GO:0005634 | inferred from direct assay axon ; GO:0030424 | inferred from direct assay cytoplasm ; GO:0005737 | inferred from direct assay "CG44424, rad, CG42629, CG42628, rsh, CG15720, CG4346, radish, CG4368, CG18646, Rad, FBpp0073550, R5_X:12971309..12973132" "IPR000210:BTB/POZ domain, IPR000331:Rap GTPase activating protein domain, IPR011333:SKP1/BTB/POZ domain, IPR001781:Zinc finger, LIM-type" CG44424 27-Aug-18 DroID_v2018_08 "Drer\si:ch211-182d3.1, Drer\zmp:0000001168, Drer\si:dkey-166d12.2, Drer\sipa1l3, Drer\sipa1l2, Drer\rap1gap2a, Drer\sipa1l1, Drer\LOC101882292, Drer\ralgapa2" - Cele\sipa-1 "Xtro\sipa1l1, Xtro\rap1gap, Xtro\ralgapa1, Xtro\rap1gap2, Xtro\garnl3" "Mmus\Rap1gap2, Mmus\Sipa1l1, Mmus\Sipa1, Mmus\Ralgapa1, Mmus\Sipa1l3, Mmus\Ralgapa2, Mmus\Rap1gap, Mmus\Sipa1l2, Mmus\Garnl3" "Hsap\SIPA1L2, Hsap\RAP1GAP, Hsap\SIPA1L1, Hsap\SIPA1, Hsap\SIPA1L3, Hsap\RALGAPA1, Hsap\GARNL3, Hsap\RALGAPA2, Hsap\RAP1GAP2" DRSC22865 IE -1.527563262 -0.024275387 -0.767896929 -1.776137846 -0.466784737 -0.017405572 FBgn0037175 CG14455 - http://flybase.org/reports/FBgn0037175 protein_coding_gene enzyme activator activity ; GO:0008047 | inferred from electronic annotation with InterPro:IPR028996 ganglioside catabolic process ; GO:0006689 | inferred from electronic annotation with InterPro:IPR028996 - CG14455 "IPR028996:Ganglioside GM2 activator, IPR010512:Protein of unknown function DUF1091" CG14455 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0053127 CG33127 - http://flybase.org/reports/FBgn0053127 protein_coding_gene "serine-type endopeptidase activity ; GO:0004252 | inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114" "proteolysis ; GO:0006508 | inferred from electronic annotation with InterPro:IPR001254, InterPro:IPR001314, InterPro:IPR018114" - CG33127 "IPR001254:Serine proteases, trypsin domain, IPR001314:Peptidase S1A, chymotrypsin family, IPR009003:Peptidase S1, PA clan, IPR018114:Serine proteases, trypsin family, histidine active site" CG33127 27-Aug-18 DroID_v2018_08 "Drer\prss60.2, Drer\prss60.1, Drer\try, Drer\prss60.3" - "Cele\try-3, Cele\svh-1" - "Mmus\1810009J06Rik, Mmus\2210010C04Rik, Mmus\Klk1b3" - FBgn0061166 l(1)3Ar lethal (1) 3Ar http://flybase.org/reports/FBgn0061166 gene - - - l(1)3Ar - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal,recessive" FBgn0035878 CG7182 - http://flybase.org/reports/FBgn0035878 protein_coding_gene - - - CG7182 IPR013126:Heat shock protein 70 family CG7182 27-Aug-18 DroID_v2018_08 "Drer\hsp70.1, Drer\hsp70l, Drer\hspa5, Drer\hspa14, Drer\hspa12b, Drer\si:dkey-4p15.3, Drer\hsp70.2, Drer\hspa4l, Drer\hspa12a, Drer\hsc70, Drer\hspa13, Drer\si:ch211-199o1.2, Drer\hspa8" "Scer\KAR2, Scer\SSA2, Scer\SSQ1, Scer\SSB2, Scer\SSA4, Scer\SSZ1, Scer\SSA1, Scer\SSB1, Scer\SSA3" Cele\F11F1.1 "Xtro\hspa1l, Xtro\hspa1b, Xtro\hspa14, Xtro\hspa1a, Xtro\hsp70, Xtro\hspa8, Xtro\hspa5, Xtro\hspa2, Xtro\hspa12b, Xtro\hspa13" "Mmus\Hspa1l, Mmus\Hspa12b, Mmus\Hspa13, Mmus\Hspa4l, Mmus\Hspa2, Mmus\Hspa1a, Mmus\Hspa14, Mmus\Hspa4, Mmus\Hspa12a, Mmus\Hspa5, Mmus\Hspa8" "Hsap\HSPA1B, Hsap\HSPA8, Hsap\HSPA1L, Hsap\HSPA12B, Hsap\HSPA2, Hsap\HSPA4L, Hsap\HSPA5, Hsap\HSPA13, Hsap\HSPA14, Hsap\HSPA12A, Hsap\HSPA6, Hsap\HSPA1A" viable embryonic/larval hemocyte | third instar larval stage FBgn0019885 anon-63BC-T2 anon-63BC-T2 http://flybase.org/reports/FBgn0019885 - gene - - - "T2, 63B-T2, anon-63BC-T2" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0038653 Octalpha2R - http://flybase.org/reports/FBgn0038653 protein_coding_gene heterotrimeric G-protein binding ; GO:0032795 | inferred from sequence or structural similarity with HGNC:281 G-protein coupled amine receptor activity ; GO:0008227 | inferred from sequence or structural similarity with HGNC:281 adrenergic receptor activity ; GO:0004935 | inferred from biological aspect of ancestor with PANTHER:PTN000664502 cell-cell signaling ; GO:0007267 | inferred from biological aspect of ancestor with PANTHER:PTN000664502 G-protein coupled receptor signaling pathway ; GO:0007186 | inferred from sequence or structural similarity with HGNC:281 adenylate cyclase-activating adrenergic receptor signaling pathway ; GO:0071880 | inferred from biological aspect of ancestor with PANTHER:PTN001205212 integral component of plasma membrane ; GO:0005887 | inferred from biological aspect of ancestor with PANTHER:PTN000664502 integral component of plasma membrane ; GO:0005887 | inferred from sequence or structural similarity with HGNC:281 CG18208 "IPR000276:G protein-coupled receptor, rhodopsin-like, IPR017452:GPCR, rhodopsin-like, 7TM" CG18208 27-Aug-18 DroID_v2018_08 "Drer\drd2b, Drer\htr1aa, Drer\drd2l, Drer\adra2db, Drer\htr1b, Drer\htr1d, Drer\adra2a, Drer\adra2da, Drer\LOC100330650, Drer\adra2c, Drer\drd2a, Drer\adra2b" - "Cele\ser-2, Cele\ser-4, Cele\ser-7, Cele\octr-1" "Xtro\adra2c, Xtro\adra2b, Xtro\adra2a, Xtro\htr1b" "Mmus\Htr1a, Mmus\Adra2c, Mmus\Olfr683, Mmus\Olfr919, Mmus\Adra2a, Mmus\Htr1b, Mmus\Olfr1101, Mmus\Adra2b, Mmus\Olfr275, Mmus\Drd2, Mmus\Htr1f, Mmus\Olfr684, Mmus\Olfr150, Mmus\Htr7, Mmus\Htr1d" "Hsap\HTR1F, Hsap\OR56A4, Hsap\HTR1B, Hsap\OR56A5, Hsap\HTR7, Hsap\ADRA2C, Hsap\HTR1A, Hsap\HTR1D, Hsap\DRD2, Hsap\OR5T1, Hsap\OR13F1, Hsap\ADRA2A, Hsap\OR56A1, Hsap\ADRA2B" "viable,fertile,visible" mesothoracic tergum FBgn0035648 CG13288 - http://flybase.org/reports/FBgn0035648 protein_coding_gene - - integral component of membrane ; GO:0016021 | inferred from sequence model "CG13288, dmCG13288" IPR031720:Protein of unknown function DUF4728 CG13288 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0266107 mei-175 meiotic 175 http://flybase.org/reports/FBgn0266107 gene - female meiotic division ; GO:0007143 | inferred from mutant phenotype - mei-175 - - 27-Aug-18 DroID_v2018_08 - - - - - - "viable,meiotic cell cycle defective,female" FBgn0083999 CG41432 - http://flybase.org/reports/FBgn0083999 protein_coding_gene - - - CG41432 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0267245 lncRNA:CR45685 - http://flybase.org/reports/FBgn0267245 non_protein_coding_gene - - - CR45685 - CR45685 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0266745 CG45218 - http://flybase.org/reports/FBgn0266745 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG45218 - CG45218 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0261926 CG42793 - http://flybase.org/reports/FBgn0261926 protein_coding_gene - - - "CG42793, CG43203" - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0033043 Or42b Odorant receptor 42b http://flybase.org/reports/FBgn0033043 protein_coding_gene olfactory receptor activity ; GO:0004984 | inferred from mutant phenotype odorant binding ; GO:0005549 | inferred from sequence or structural similarity with Or43b sensory perception of smell ; GO:0007608 | inferred from mutant phenotype integral component of membrane ; GO:0016021 | inferred from biological aspect of ancestor with PANTHER:PTN000474402 plasma membrane ; GO:0005886 | inferred from biological aspect of ancestor with PANTHER:PTN000474402 dendrite membrane ; GO:0032590 | inferred from sequence or structural similarity with Or22a "42b, DOR118, 41E.1, CG12754, Or42b, OR42b" "IPR004117:Olfactory receptor, insect" CG12754 27-Aug-18 DroID_v2018_08 - - - - - - "viable,fertile,smell perception defective" FBgn0030091 CG7065 - http://flybase.org/reports/FBgn0030091 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG7065 - CG7065 27-Aug-18 DroID_v2018_08 "Drer\smarca4a, Drer\smarca2" "Scer\STH1, Scer\SNF2" "Cele\C52B9.8, Cele\swsn-4" - "Mmus\Smarca4, Mmus\Smarca2" "Hsap\SMARCA4, Hsap\SMARCA2" "lethal,some die during pupal stage,viable" DRSC25280 K 0.304504596 1.188708194 1.426216408 1.069094513 1.723976147 0.825441875 FBgn0265015 S042938 - http://flybase.org/reports/FBgn0265015 gene - - - S042938 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0084606 1038 1038 http://flybase.org/reports/FBgn0084606 gene - - - 1038 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0026636 l(2)k15801 lethal (2) k15801 http://flybase.org/reports/FBgn0026636 - gene - - - l(2)k15801 - - 27-Aug-18 DroID_v2018_08 - - - - - - lethal FBgn0015217 E(var)53E Enhancer of variegation 53E http://flybase.org/reports/FBgn0015217 - gene - - - "E(var)2-53E, E(var)53E" - - 27-Aug-18 DroID_v2018_08 - - - - - - "female sterile,recessive,enhancer of variegation,dominant" FBgn0267531 asRNA:CR45871 - http://flybase.org/reports/FBgn0267531 non_protein_coding_gene - - - CR45871 - CR45871 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0002731 mfs(3)G male female sterile G http://flybase.org/reports/FBgn0002731 - gene - - - "fs(3)4, mfs(3)G" - - 27-Aug-18 DroID_v2018_08 - - - - - - "female sterile,male sterile,viable,poor,visible" "egg chamber,adult fat body,metathoracic tibia,metathoracic tarsal segment" FBgn0036157 CG7560 - http://flybase.org/reports/FBgn0036157 protein_coding_gene methylenetetrahydrofolate reductase (NAD(P)H) activity ; GO:0004489 | inferred from biological aspect of ancestor with PANTHER:PTN000472667 oxidation-reduction process ; GO:0055114 | inferred from electronic annotation with InterPro:IPR003171 methionine metabolic process ; GO:0006555 | inferred from electronic annotation with InterPro:IPR003171 one-carbon metabolic process ; GO:0006730 | inferred from biological aspect of ancestor with PANTHER:PTN000472667 cytosol ; GO:0005829 | inferred from biological aspect of ancestor with PANTHER:PTN000472667 "gh18008, BEST:GH18008, CG7560" "IPR003171:Methylenetetrahydrofolate reductase, IPR029041:FAD-linked oxidoreductase-like" CG7560 27-Aug-18 DroID_v2018_08 Drer\mthfr "Scer\MET12, Scer\MET13" Cele\mthf-1 "Xtro\mthfr, Xtro\lcor" Mmus\Mthfr Hsap\MTHFR viable FBgn0033481 CG12920 - http://flybase.org/reports/FBgn0033481 protein_coding_gene molecular_function ; GO:0003674 | no biological data available biological_process ; GO:0008150 | no biological data available cellular_component ; GO:0005575 | no biological data available CG12920 - CG12920 27-Aug-18 DroID_v2018_08 - - - - - - viable FBgn0264517 asRNA:CR43916 - http://flybase.org/reports/FBgn0264517 non_protein_coding_gene - - - CR43916 - CR43916 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0000803 fs(1)de14 female sterile (1) defective eggs 14 http://flybase.org/reports/FBgn0000803 - gene - - - "de14, fs(1)de14" - - 27-Aug-18 DroID_v2018_08 - - - - - - female sterile "dorsal appendage,chorion,endochorion" FBgn0264702 asRNA:CR43971 - http://flybase.org/reports/FBgn0264702 non_protein_coding_gene - - - CR43971 - CR43971 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0083997 CG41355 - http://flybase.org/reports/FBgn0083997 protein_coding_gene - - - CG41355 - - 27-Aug-18 DroID_v2018_08 - - - - - - FBgn0004073 fs(2)mel7 female sterile (2) maternal effect lethal 7 http://flybase.org/reports/FBgn0004073 - gene - - - "Mel 7, fs(2)mel7" - - 27-Aug-18 DroID_v2018_08 - - - - - - "lethal - all die before end of embryonic stage,maternal effect,semidominant,some die during embryonic stage" "embryonic/larval posterior spiracle,maternal effect" FBgn0016043 lup-1 loop unfolding protein-1 http://flybase.org/reports/FBgn0016043 - gene - sperm axonem